SERF1B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SERF1B
Entrez Gene ID	728492
Full Name	small EDRK-rich factor 1B
Synonyms	FAM2B,H4F5C,h4F5
General protein information	Preferred Names small EDRK-rich factor 1B Names small EDRK-rich factor 1 SMA modifier 1 protein 4F5 small EDRK-rich factor 1B (centromeric)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q13.2
Summary	This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This gene is the centromeric copy which is identical to the telomeric copy. Alternatively spliced transcripts have been documented but it is unclear whether alternative splicing occurs for both the centromeric and telomeric copies of the gene. The gene encodes a protein of unknown function which bears low-level homology with the RNA-binding domain of matrin-cyclophilin, a protein which colocalizes with small nuclear ribonucleoproteins (snRNPs) and the SMN1 gene product. [provided by RefSeq, Jul 2008].

mRNA and Protein(s)

mRNA	Protein	Name
NM_022978.3	NP_075267.1	small EDRK-rich factor 1 isoform 2
NM_022978.2	NP_075267.1	small EDRK-rich factor 1 isoform 2
NM_001178087.1	NP_001171558.1	small EDRK-rich factor 1 isoform 1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	SERF1A	XP_003433867.1
Homo sapiens (human)	SERF1A	NP_075257.1
Bos taurus (cattle)	SERF1A	NP_001106772.1
Mus musculus (house mouse)	Serf1	NP_035483.1
Pan troglodytes (chimpanzee)	SERF1B	XP_003310742.1
Homo sapiens (human)	SERF1B	NP_001171558.1
Rattus norvegicus (Norway rat)	Serf1	XP_577983.3

Gene Ontology
Bibliography

Related articles in PubMed

SERF protein is a direct modifier of amyloid fiber assembly.
Falsone SF, Meyer NH, Schrank E, Leitinger G, Pham CL, Fodero-Tavoletti MT, Holmberg M, Dulle M, Scicluna B, Gesslbauer B, R?ckert HM, Wagner GE, Merle DA, Nollen EA, Kungl AJ, Hill AF, Cappai R, Zangger K
Cell reports2(2)358-71(2012 Aug)

Identification of MOAG-4/SERF as a regulator of age-related proteotoxicity.
van Ham TJ, Holmberg MA, van der Goot AT, Teuling E, Garcia-Arencibia M, Kim HE, Du D, Thijssen KL, Wiersma M, Burggraaff R, van Bergeijk P, van Rheenen J, Jerre van Veluw G, Hofstra RM, Rubinsztein DC, Nollen EA
Cell142(4)601-12(2010 Aug)

Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis.
Tomarev SI, Wistow G, Raymond V, Dubois S, Malyukova I
Investigative ophthalmology & visual science44(6)2588-96(2003 Jun)

Comparative sequence analysis of the mouse and human Lgn1/SMA interval.
Endrizzi M, Huang S, Scharf JM, Kelter AR, Wirth B, Kunkel LM, Miller W, Dietrich WF
Genomics60(2)137-51(1999 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following SERF1B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SERF1B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31572	NM_022978.3 Latest version!	Homo sapiens small EDRK-rich factor 1B (SERF1B), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu31724	NM_001178087.1 Latest version!	Homo sapiens small EDRK-rich factor 1B (SERF1B), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu31572	NM_022978.2	Homo sapiens small EDRK-rich factor 1B (SERF1B), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SERF1B ( NM_022978.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_075267.1 Homo sapiens small EDRK-rich factor 1B (SERF1B), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu31572
Clone ID Related Accession (Same CDS sequence)	NM_022978.3 , NM_022978.2
Accession Version	NM_022978.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 333bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-26
Organism	Homo sapiens(human)
Product	small EDRK-rich factor 1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB454907.1, AC139277.2, BC103687.1, BC104738.1 and BM686659.1. On Sep 3, 2019 this sequence version replaced NM_022978.2. Transcript Variant: This variant (2) has an alternate 3' exon, as compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, as compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: SRR7410571.101111.1, SRR7410571.101097.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCCGTG GAAATCAACG AGAACTTGCC CGCCAGAAAA ACATGAAGAA AACCCAGGAA 
ATTAGCAAGG GAAAGAGGAA AGAGGATAGC TTGACTGCCT CTCAGAGAAA GCAGAGTTCT 
GGAGGCCAGA AATCTGAGAG CAAGATGTCA GCTGGGCCAC ACCTCCCTCT GAAGGCTCCA 
AGGGAGAATC CTTGCTTTCC TCTTCCAGCT GCTGGTGGCT CCAGGTATTA CTTGGCTTAT 
GGCAGCATAA CTCCTATCTC TGCCTTTGTC TTTGTGGTCT TCTTTTCTGT CTTCTTCCCT 
TCTTTTTATG AGGACTTTTG CTGTTGGATT TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_075267.1
CDS	202..534
Translation	MARGNQRELARQKNMKKTQEISKGKRKEDSLTASQRKQSSGGQKSESKMSAGPHLPLKAPRENPCFPLPAAGGSRYYLAYGSITPISAFVFVVFFSVFFPSFYEDFCCWI

Target ORF information:

RefSeq Version	NM_022978.3
Organism	Homo sapiens(human)
Definition	Homo sapiens small EDRK-rich factor 1B (SERF1B), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022978.3

ORF Insert Sequence:

ATGGCCCGTG GAAATCAACG AGAACTTGCC CGCCAGAAAA ACATGAAGAA AACCCAGGAA 
ATTAGCAAGG GAAAGAGGAA AGAGGATAGC TTGACTGCCT CTCAGAGAAA GCAGAGTTCT 
GGAGGCCAGA AATCTGAGAG CAAGATGTCA GCTGGGCCAC ACCTCCCTCT GAAGGCTCCA 
AGGGAGAATC CTTGCTTTCC TCTTCCAGCT GCTGGTGGCT CCAGGTATTA CTTGGCTTAT 
GGCAGCATAA CTCCTATCTC TGCCTTTGTC TTTGTGGTCT TCTTTTCTGT CTTCTTCCCT 
TCTTTTTATG AGGACTTTTG CTGTTGGATT TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SERF1B ( NM_022978.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_075267.1 Homo sapiens small EDRK-rich factor 1B (SERF1B), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu31572
Clone ID Related Accession (Same CDS sequence)	NM_022978.3 , NM_022978.2
Accession Version	NM_022978.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 333bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-30
Organism	Homo sapiens(human)
Product	small EDRK-rich factor 1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB454907.1, BC103687.1, BC104738.1 and BM686659.1. On May 13, 2010 this sequence version replaced NM_022978.1. Transcript Variant: This variant (2) has an alternate 3' exon, as compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, as compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.191220.1, SRR1803615.258238.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCCGTG GAAATCAACG AGAACTTGCC CGCCAGAAAA ACATGAAGAA AACCCAGGAA 
ATTAGCAAGG GAAAGAGGAA AGAGGATAGC TTGACTGCCT CTCAGAGAAA GCAGAGTTCT 
GGAGGCCAGA AATCTGAGAG CAAGATGTCA GCTGGGCCAC ACCTCCCTCT GAAGGCTCCA 
AGGGAGAATC CTTGCTTTCC TCTTCCAGCT GCTGGTGGCT CCAGGTATTA CTTGGCTTAT 
GGCAGCATAA CTCCTATCTC TGCCTTTGTC TTTGTGGTCT TCTTTTCTGT CTTCTTCCCT 
TCTTTTTATG AGGACTTTTG CTGTTGGATT TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_075267.1
CDS	202..534
Translation	MARGNQRELARQKNMKKTQEISKGKRKEDSLTASQRKQSSGGQKSESKMSAGPHLPLKAPRENPCFPLPAAGGSRYYLAYGSITPISAFVFVVFFSVFFPSFYEDFCCWI

Target ORF information:

RefSeq Version	NM_022978.2
Organism	Homo sapiens(human)
Definition	Homo sapiens small EDRK-rich factor 1B (SERF1B), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022978.2

ORF Insert Sequence:

ATGGCCCGTG GAAATCAACG AGAACTTGCC CGCCAGAAAA ACATGAAGAA AACCCAGGAA 
ATTAGCAAGG GAAAGAGGAA AGAGGATAGC TTGACTGCCT CTCAGAGAAA GCAGAGTTCT 
GGAGGCCAGA AATCTGAGAG CAAGATGTCA GCTGGGCCAC ACCTCCCTCT GAAGGCTCCA 
AGGGAGAATC CTTGCTTTCC TCTTCCAGCT GCTGGTGGCT CCAGGTATTA CTTGGCTTAT 
GGCAGCATAA CTCCTATCTC TGCCTTTGTC TTTGTGGTCT TCTTTTCTGT CTTCTTCCCT 
TCTTTTTATG AGGACTTTTG CTGTTGGATT TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SERF1B ( NM_001178087.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001171558.1 Homo sapiens small EDRK-rich factor 1B (SERF1B), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu31724
Clone ID Related Accession (Same CDS sequence)	NM_001178087.1
Accession Version	NM_001178087.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 189bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-17
Organism	Homo sapiens(human)
Product	small EDRK-rich factor 1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB454907.1 and CD679521.1. Transcript Variant: This variant (1) encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: SRR1163657.25099.1, SRR1163655.473294.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCCGTG GAAATCAACG AGAACTTGCC CGCCAGAAAA ACATGAAGAA AACCCAGGAA 
ATTAGCAAGG GAAAGAGGAA AGAGGATAGC TTGACTGCCT CTCAGAGAAA GCAGAGGGAC 
TCTGAGATCA TGCAAGAAAA GCAGAAGGCA GCTAATGAGA AGAAGTCTAT GCAGACAAGA 
GAAAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001171558.1
CDS	202..390
Translation	MARGNQRELARQKNMKKTQEISKGKRKEDSLTASQRKQRDSEIMQEKQKAANEKKSMQTREK

Target ORF information:

RefSeq Version	NM_001178087.1
Organism	Homo sapiens(human)
Definition	Homo sapiens small EDRK-rich factor 1B (SERF1B), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001178087.1

ORF Insert Sequence:

ATGGCCCGTG GAAATCAACG AGAACTTGCC CGCCAGAAAA ACATGAAGAA AACCCAGGAA 
ATTAGCAAGG GAAAGAGGAA AGAGGATAGC TTGACTGCCT CTCAGAGAAA GCAGAGGGAC 
TCTGAGATCA TGCAAGAAAA GCAGAAGGCA GCTAATGAGA AGAAGTCTAT GCAGACAAGA 
GAAAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

SERF protein is a direct modifier of amyloid fiber assembly.
Cell reports2(2)358-71(2012 Aug)
Falsone SF,Meyer NH,Schrank E,Leitinger G,Pham CL,Fodero-Tavoletti MT,Holmberg M,Dulle M,Scicluna B,Gesslbauer B,R?ckert HM,Wagner GE,Merle DA,Nollen EA,Kungl AJ,Hill AF,Cappai R,Zangger K

Identification of MOAG-4/SERF as a regulator of age-related proteotoxicity.
Cell142(4)601-12(2010 Aug)
van Ham TJ,Holmberg MA,van der Goot AT,Teuling E,Garcia-Arencibia M,Kim HE,Du D,Thijssen KL,Wiersma M,Burggraaff R,van Bergeijk P,van Rheenen J,Jerre van Veluw G,Hofstra RM,Rubinsztein DC,Nollen EA

Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis.
Investigative ophthalmology & visual science44(6)2588-96(2003 Jun)
Tomarev SI,Wistow G,Raymond V,Dubois S,Malyukova I

Comparative sequence analysis of the mouse and human Lgn1/SMA interval.
Genomics60(2)137-51(1999 Sep)
Endrizzi M,Huang S,Scharf JM,Kelter AR,Wirth B,Kunkel LM,Miller W,Dietrich WF

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SERF1B cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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