KRTAP1-4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KRTAP1-4
Entrez Gene ID	728255
Full Name	keratin associated protein 1-4
Synonyms	KAP1.4,KRTAP1.4
General protein information	Preferred Names keratin associated protein 1-4 Names keratin-associated protein 1-4 high sulfur keratin-associated protein 1.4 keratin-associated protein 1.4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q21.2
Summary	The main structural proteins of mammalian hair fiber are the hair keratins (see MIM 601077) and the keratin-associated proteins (KAPs), which form a rigid and resistant hair shaft through extensive disulfide bond crosslinking with the abundant cysteines of hair keratins (Shimomura et al., 2002 [PubMed 12228244]).[supplied by OMIM, Jan 2009].
Disorder MIM:	608821

mRNA and Protein(s)

mRNA	Protein	Name
NM_001257305.1	NP_001244234.1	keratin-associated protein 1-4

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	KRTAP1-4	XP_001147248.3
Homo sapiens (human)	KRTAP1-4	NP_001244234.1

Gene Ontology
Bibliography

Related articles in PubMed

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
Zody MC, Garber M, Adams DJ, Sharpe T, Harrow J, Lupski JR, Nicholson C, Searle SM, Wilming L, Young SK, Abouelleil A, Allen NR, Bi W, Bloom T, Borowsky ML, Bugalter BE, Butler J, Chang JL, Chen CK, Cook A, Corum B, Cuomo CA, de Jong PJ, DeCaprio D, Dewar K, FitzGerald M, Gilbert J, Gibson R, Gnerre S, Goldstein S, Grafham DV, Grocock R, Hafez N, Hagopian DS, Hart E, Norman CH, Humphray S, Jaffe DB, Jones M, Kamal M, Khodiyar VK, LaButti K, Laird G, Lehoczky J, Liu X, Lokyitsang T, Loveland J, Lui A, Macdonald P, Major JE, Matthews L, Mauceli E, McCarroll SA, Mihalev AH, Mudge J, Nguyen C, Nicol R, O'Leary SB, Osoegawa K, Schwartz DC, Shaw-Smith C, Stankiewicz P, Steward C, Swarbreck D, Venkataraman V, Whittaker CA, Yang X, Zimmer AR, Bradley A, Hubbard T, Birren BW, Rogers J, Lander ES, Nusbaum C
Nature440(7087)1045-9(2006 Apr)

Polymorphisms in the human high sulfur hair keratin-associated protein 1, KAP1, gene family.
Shimomura Y, Aoki N, Schweizer J, Langbein L, Rogers MA, Winter H, Ito M
The Journal of biological chemistry277(47)45493-501(2002 Nov)

Characterization of a cluster of human high/ultrahigh sulfur keratin-associated protein genes embedded in the type I keratin gene domain on chromosome 17q12-21.
Rogers MA, Langbein L, Winter H, Ehmann C, Praetzel S, Korn B, Schweizer J
The Journal of biological chemistry276(22)19440-51(2001 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

no polymorphic alleles were found for the hKAP1.4 and hKAP1.5 genes in Japanese and Caucasian individuals
Title: Polymorphisms in the human high sulfur hair keratin-associated protein 1, KAP1, gene family.

The following KRTAP1-4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KRTAP1-4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu56004	NM_001257305.1 Latest version!	Homo sapiens keratin associated protein 1-4 (KRTAP1-4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KRTAP1-4 ( NM_001257305.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001244234.1 Homo sapiens keratin associated protein 1-4 (KRTAP1-4), mRNA.

Price & Availability↑

CloneID	OHu56004
Clone ID Related Accession (Same CDS sequence)	NM_001257305.1
Accession Version	NM_001257305.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 366bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-30
Organism	Homo sapiens(human)
Product	keratin-associated protein 1-4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC007455.7. On or before Sep 27, 2012 this sequence version replaced XM_003846480.1, XM_003846598.1, XM_003846286.1. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGCCAGCT GTTCCACCAG TGGGACCTGT GGCTCCAGCT GCTGCCAGCC AAGCTGCTGT 
GAAACTAGCT GCTGCCAGCC AAGCTGCTGC CAGACCAGCT CCTGCGGAAC CGGCTGTGGC 
ATTGGTGGTG GCATTGGCTA TGGCCAGGAG GGCAGCGGTG GATCTGTGAG CACCCGTATC 
AGGTGGTGCC ACCCAGATTG CCACGTGGAG GGCACCTGCC TGCCCCCCTG CTACCTGGTA 
AGCTGCACAC CCCCATCCTG CTGCCAGCTG CACCACGCCG AGGCCTCCTG CTGCCGCCCG 
TCCTACTGTG GACAGTCCTG CTGCCGCCCA GCCTGCTGCT GCCACTGCTG TGAGCCCACC 
TGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001244234.1
CDS	48..413
Translation	MASCSTSGTCGSSCCQPSCCETSCCQPSCCQTSSCGTGCGIGGGIGYGQEGSGGSVSTRIRWCHPDCHVEGTCLPPCYLVSCTPPSCCQLHHAEASCCRPSYCGQSCCRPACCCHCCEPTC

Target ORF information:

RefSeq Version	NM_001257305.1
Organism	Homo sapiens(human)
Definition	Homo sapiens keratin associated protein 1-4 (KRTAP1-4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001257305.1

ORF Insert Sequence:

ATGGCCAGCT GTTCCACCAG TGGGACCTGT GGCTCCAGCT GCTGCCAGCC AAGCTGCTGT 
GAAACTAGCT GCTGCCAGCC AAGCTGCTGC CAGACCAGCT CCTGCGGAAC CGGCTGTGGC 
ATTGGTGGTG GCATTGGCTA TGGCCAGGAG GGCAGCGGTG GATCTGTGAG CACCCGTATC 
AGGTGGTGCC ACCCAGATTG CCACGTGGAG GGCACCTGCC TGCCCCCCTG CTACCTGGTA 
AGCTGCACAC CCCCATCCTG CTGCCAGCTG CACCACGCCG AGGCCTCCTG CTGCCGCCCG 
TCCTACTGTG GACAGTCCTG CTGCCGCCCA GCCTGCTGCT GCCACTGCTG TGAGCCCACC 
TGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
Nature440(7087)1045-9(2006 Apr)
Zody MC,Garber M,Adams DJ,Sharpe T,Harrow J,Lupski JR,Nicholson C,Searle SM,Wilming L,Young SK,Abouelleil A,Allen NR,Bi W,Bloom T,Borowsky ML,Bugalter BE,Butler J,Chang JL,Chen CK,Cook A,Corum B,Cuomo CA,de Jong PJ,DeCaprio D,Dewar K,FitzGerald M,Gilbert J,Gibson R,Gnerre S,Goldstein S,Grafham DV,Grocock R,Hafez N,Hagopian DS,Hart E,Norman CH,Humphray S,Jaffe DB,Jones M,Kamal M,Khodiyar VK,LaButti K,Laird G,Lehoczky J,Liu X,Lokyitsang T,Loveland J,Lui A,Macdonald P,Major JE,Matthews L,Mauceli E,McCarroll SA,Mihalev AH,Mudge J,Nguyen C,Nicol R,O'Leary SB,Osoegawa K,Schwartz DC,Shaw-Smith C,Stankiewicz P,Steward C,Swarbreck D,Venkataraman V,Whittaker CA,Yang X,Zimmer AR,Bradley A,Hubbard T,Birren BW,Rogers J,Lander ES,Nusbaum C

Polymorphisms in the human high sulfur hair keratin-associated protein 1, KAP1, gene family.
The Journal of biological chemistry277(47)45493-501(2002 Nov)
Shimomura Y,Aoki N,Schweizer J,Langbein L,Rogers MA,Winter H,Ito M

Characterization of a cluster of human high/ultrahigh sulfur keratin-associated protein genes embedded in the type I keratin gene domain on chromosome 17q12-21.
The Journal of biological chemistry276(22)19440-51(2001 Jun)
Rogers MA,Langbein L,Winter H,Ehmann C,Praetzel S,Korn B,Schweizer J

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KRTAP1-4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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