PHLDA2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PHLDA2
Entrez Gene ID	7262
Full Name	pleckstrin homology like domain family A member 2
Synonyms	BRW1C,BWR1C,HLDA2,IPL,TSSC3
General protein information	Preferred Names pleckstrin homology like domain family A member 2 Names pleckstrin homology-like domain family A member 2 beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein imprinted in placenta and liver protein p17-BWR1C p17-Beckwith-Wiedemann region 1 C p17-Beckwith-Wiedemann region 1C tumor suppressing subchromosomal transferable fragment cDNA 3 tumor suppressing subtransferable candidate 3 tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein tumor-supressing STF cDNA 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11p15.4
Summary	This gene is located in a cluster of imprinted genes on chromosome 11p15.5, which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene has been shown to be imprinted, with preferential expression from the maternal allele in placenta and liver. [provided by RefSeq, Oct 2010].
Disorder MIM:	602131

mRNA and Protein(s)

mRNA	Protein	Name
NM_003311.4	NP_003302.1	pleckstrin homology-like domain family A member 2
NM_003311.3	NP_003302.1	pleckstrin homology-like domain family A member 2

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	phlda2	NP_001018432.1
Xenopus tropicalis (tropical clawed frog)	phlda2	NP_001072825.1
Homo sapiens (human)	PHLDA2	NP_003302.1
	PHLDA2	XP_001094620.1
Gallus gallus (chicken)	PHLDA2	NP_001186524.1
Rattus norvegicus (Norway rat)	Phlda2	NP_001093991.1
Pan troglodytes (chimpanzee)	PHLDA2	XP_001155149.1
Bos taurus (cattle)	PHLDA2	NP_001069989.1
Mus musculus (house mouse)	Phlda2	NP_033460.1

Gene Ontology
Bibliography

Related articles in PubMed

RanBP9/TSSC3 complex cooperates to suppress anoikis resistance and metastasis via inhibiting Src-mediated Akt signaling in osteosarcoma.
Dai H, Lv YF, Yan GN, Meng G, Zhang X, Guo QN
Cell death & disease7(12)e2572(2016 Dec)

Lentivirus-mediated PHLDA2 overexpression inhibits trophoblast proliferation, migration and invasion, and induces apoptosis.
Jin F, Qiao C, Luan N, Li H
International journal of molecular medicine37(4)949-57(2016 Apr)

The expression of TSSC3 and its prognostic value in patients with osteosarcoma.
Wang X, He H, Zhang K, Peng W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie7923-6(2016 Apr)

Placental PHLDA2 expression is increased in cases of fetal growth restriction following reduced fetal movements.
Janssen AB, Tunster SJ, Heazell AE, John RM
BMC medical genetics1717(2016 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

RanBP9/TSSC3 complex cooperatively suppress metastasis via downregulation of Src-dependent Akt pathway to expedite mitochondrial-associated anoikis.
Title: RanBP9/TSSC3 complex cooperates to suppress anoikis resistance and metastasis via inhibiting Src-mediated Akt signaling in osteosarcoma.

TSSC3 downregulation promotes the Epithelial to mesenchymal transition (EMT) of osteosarcoma cells by regulating EMT markers via a signal transduction pathway that involves Snail, Wnt-beta-catenin/TCF, and GSK-3beta
Title: Downregulation of tumor suppressing STF cDNA 3 promotes epithelial-mesenchymal transition and tumor metastasis of osteosarcoma by the Wnt/GSK-3?/?-catenin/Snail signaling pathway.

PHLDA2 plays an important role in the occurrence and development of pregnancy complications by promoting trophoblast apoptosis and suppressing cell invasion.
Title: Lentivirus-mediated PHLDA2 overexpression inhibits trophoblast proliferation, migration and invasion, and induces apoptosis.

TSSC3 was a prognostic marker in osteosarcoma.
Title: The expression of TSSC3 and its prognostic value in patients with osteosarcoma.

Placental PHLDA2 expression was significantly 2.3 fold higher in reduced fetal movements pregnancies resulting in delivery of a growth restricted compared with a normal birth weight infant.
Title: Placental PHLDA2 expression is increased in cases of fetal growth restriction following reduced fetal movements.

The following PHLDA2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PHLDA2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19576	NM_003311.4 Latest version!	Homo sapiens pleckstrin homology like domain family A member 2 (PHLDA2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu19576	NM_003311.3	Homo sapiens pleckstrin homology like domain family A member 2 (PHLDA2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PHLDA2 ( NM_003311.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003302.1 Homo sapiens pleckstrin homology like domain family A member 2 (PHLDA2), mRNA.

Price & Availability↑

CloneID	OHu19576
Clone ID Related Accession (Same CDS sequence)	NM_003311.4 , NM_003311.3
Accession Version	NM_003311.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 459bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-25
Organism	Homo sapiens(human)
Product	pleckstrin homology-like domain family A member 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF035444.1 and AI659266.1. This sequence is a reference standard in the RefSeqGene project. On Nov 24, 2018 this sequence version replaced NM_003311.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF035444.1, BU500509.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## imprinted gene :: PMID: 9328465 MANE Ensembl match :: ENST00000314222.5/ ENSP00000319231.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAATCCC CCGACGAGGT GCTACGCGAG GGCGAGTTGG AGAAGCGCAG CGACAGCCTC 
TTCCAGCTAT GGAAGAAGAA GCGCGGGGTG CTCACCTCCG ACCGCCTGAG CCTGTTCCCC 
GCCAGCCCCC GCGCGCGCCC CAAGGAGCTG CGCTTCCACT CCATCCTCAA GGTGGACTGC 
GTGGAGCGCA CGGGCAAGTA CGTGTACTTC ACCATCGTCA CCACCGACCA CAAGGAGATC 
GACTTCCGCT GCGCGGGCGA GAGCTGCTGG AACGCGGCCA TCGCGCTGGC GCTCATCGAT 
TTCCAGAACC GCCGCGCCCT GCAGGACTTT CGCAGCCGCC AGGAACGCAC CGCACCCGCC 
GCACCCGCCG AGGACGCCGT GGCTGCCGCG GCCGCCGCAC CCTCCGAGCC CTCGGAGCCC 
TCCAGGCCAT CCCCGCAGCC CAAACCCCGC ACGCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003302.1
CDS	57..515
Translation	MKSPDEVLREGELEKRSDSLFQLWKKKRGVLTSDRLSLFPASPRARPKELRFHSILKVDCVERTGKYVYFTIVTTDHKEIDFRCAGESCWNAAIALALIDFQNRRALQDFRSRQERTAPAAPAEDAVAAAAAAPSEPSEPSRPSPQPKPRTP

Target ORF information:

RefSeq Version	NM_003311.4
Organism	Homo sapiens(human)
Definition	Homo sapiens pleckstrin homology like domain family A member 2 (PHLDA2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003311.4

ORF Insert Sequence:

ATGAAATCCC CCGACGAGGT GCTACGCGAG GGCGAGTTGG AGAAGCGCAG CGACAGCCTC 
TTCCAGCTAT GGAAGAAGAA GCGCGGGGTG CTCACCTCCG ACCGCCTGAG CCTGTTCCCC 
GCCAGCCCCC GCGCGCGCCC CAAGGAGCTG CGCTTCCACT CCATCCTCAA GGTGGACTGC 
GTGGAGCGCA CGGGCAAGTA CGTGTACTTC ACCATCGTCA CCACCGACCA CAAGGAGATC 
GACTTCCGCT GCGCGGGCGA GAGCTGCTGG AACGCGGCCA TCGCGCTGGC GCTCATCGAT 
TTCCAGAACC GCCGCGCCCT GCAGGACTTT CGCAGCCGCC AGGAACGCAC CGCACCCGCC 
GCACCCGCCG AGGACGCCGT GGCTGCCGCG GCCGCCGCAC CCTCCGAGCC CTCGGAGCCC 
TCCAGGCCAT CCCCGCAGCC CAAACCCCGC ACGCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PHLDA2 ( NM_003311.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003302.1 Homo sapiens pleckstrin homology like domain family A member 2 (PHLDA2), mRNA.

Price & Availability↑

CloneID	OHu19576
Clone ID Related Accession (Same CDS sequence)	NM_003311.4 , NM_003311.3
Accession Version	NM_003311.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 459bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-15
Organism	Homo sapiens(human)
Product	pleckstrin homology-like domain family A member 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF035444.1 and AI659266.1. This sequence is a reference standard in the RefSeqGene project. On Jan 15, 2005 this sequence version replaced NM_003311.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF035444.1, BU500509.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## imprinted gene :: PMID: 9328465 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAAATCCC CCGACGAGGT GCTACGCGAG GGCGAGTTGG AGAAGCGCAG CGACAGCCTC 
TTCCAGCTAT GGAAGAAGAA GCGCGGGGTG CTCACCTCCG ACCGCCTGAG CCTGTTCCCC 
GCCAGCCCCC GCGCGCGCCC CAAGGAGCTG CGCTTCCACT CCATCCTCAA GGTGGACTGC 
GTGGAGCGCA CGGGCAAGTA CGTGTACTTC ACCATCGTCA CCACCGACCA CAAGGAGATC 
GACTTCCGCT GCGCGGGCGA GAGCTGCTGG AACGCGGCCA TCGCGCTGGC GCTCATCGAT 
TTCCAGAACC GCCGCGCCCT GCAGGACTTT CGCAGCCGCC AGGAACGCAC CGCACCCGCC 
GCACCCGCCG AGGACGCCGT GGCTGCCGCG GCCGCCGCAC CCTCCGAGCC CTCGGAGCCC 
TCCAGGCCAT CCCCGCAGCC CAAACCCCGC ACGCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003302.1
CDS	57..515
Translation	MKSPDEVLREGELEKRSDSLFQLWKKKRGVLTSDRLSLFPASPRARPKELRFHSILKVDCVERTGKYVYFTIVTTDHKEIDFRCAGESCWNAAIALALIDFQNRRALQDFRSRQERTAPAAPAEDAVAAAAAAPSEPSEPSRPSPQPKPRTP

Target ORF information:

RefSeq Version	NM_003311.3
Organism	Homo sapiens(human)
Definition	Homo sapiens pleckstrin homology like domain family A member 2 (PHLDA2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003311.3

ORF Insert Sequence:

ATGAAATCCC CCGACGAGGT GCTACGCGAG GGCGAGTTGG AGAAGCGCAG CGACAGCCTC 
TTCCAGCTAT GGAAGAAGAA GCGCGGGGTG CTCACCTCCG ACCGCCTGAG CCTGTTCCCC 
GCCAGCCCCC GCGCGCGCCC CAAGGAGCTG CGCTTCCACT CCATCCTCAA GGTGGACTGC 
GTGGAGCGCA CGGGCAAGTA CGTGTACTTC ACCATCGTCA CCACCGACCA CAAGGAGATC 
GACTTCCGCT GCGCGGGCGA GAGCTGCTGG AACGCGGCCA TCGCGCTGGC GCTCATCGAT 
TTCCAGAACC GCCGCGCCCT GCAGGACTTT CGCAGCCGCC AGGAACGCAC CGCACCCGCC 
GCACCCGCCG AGGACGCCGT GGCTGCCGCG GCCGCCGCAC CCTCCGAGCC CTCGGAGCCC 
TCCAGGCCAT CCCCGCAGCC CAAACCCCGC ACGCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

RanBP9/TSSC3 complex cooperates to suppress anoikis resistance and metastasis via inhibiting Src-mediated Akt signaling in osteosarcoma.
Cell death & disease7(12)e2572(2016 Dec)
Dai H,Lv YF,Yan GN,Meng G,Zhang X,Guo QN

Lentivirus-mediated PHLDA2 overexpression inhibits trophoblast proliferation, migration and invasion, and induces apoptosis.
International journal of molecular medicine37(4)949-57(2016 Apr)
Jin F,Qiao C,Luan N,Li H

The expression of TSSC3 and its prognostic value in patients with osteosarcoma.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie7923-6(2016 Apr)
Wang X,He H,Zhang K,Peng W

Placental PHLDA2 expression is increased in cases of fetal growth restriction following reduced fetal movements.
BMC medical genetics1717(2016 Mar)
Janssen AB,Tunster SJ,Heazell AE,John RM

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PHLDA2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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