TSNAX cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TSNAX
Entrez Gene ID	7257
Full Name	translin associated factor X
Synonyms	TRAX
General protein information	Preferred Names translin associated factor X Names translin-associated protein X translin-like protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q42.2
Summary	This gene encodes a protein which specifically interacts with translin, a DNA-binding protein that binds consensus sequences at breakpoint junctions of chromosomal translocations. The encoded protein contains bipartite nuclear targeting sequences that may provide nuclear transport for translin, which lacks any nuclear targeting motifs. [provided by RefSeq, Jul 2008].
Disorder MIM:	602964

mRNA and Protein(s)

mRNA	Protein	Name
NM_005999.2	NP_005990.1	translin-associated protein X
NM_005999.3	NP_005990.1	translin-associated protein X

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	TSNAX	XP_514271.3
Canis lupus familiaris (dog)	TSNAX	XP_536345.2
Drosophila melanogaster (fruit fly)	Trax	NP_732021.2
Magnaporthe oryzae (rice blast fungus)	MGG_09242	XP_003709868.1
Rattus norvegicus (Norway rat)	Tsnax	NP_071598.1
Bos taurus (cattle)	TSNAX	NP_001069474.2
Danio rerio (zebrafish)	tsnax	NP_001025275.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004585	XP_315244.4
Homo sapiens (human)	TSNAX	NP_005990.1
Xenopus tropicalis (tropical clawed frog)	tsnax	NP_001006778.1
	TSNAX	XP_001104647.1
Mus musculus (house mouse)	Tsnax	NP_058605.1
Gallus gallus (chicken)	TSNAX	NP_001006403.1
Neurospora crassa	NCU06059	XP_959822.1
Arabidopsis thaliana (thale cress)	AT2G03780	NP_178473.2
Oryza sativa (rice)	Os01g0265900	NP_001042673.2

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Translin and Trax differentially regulate telomere-associated transcript homeostasis.
Gomez-Escobar N, Almobadel N, Alzahrani O, Feichtinger J, Planells-Palop V, Alshehri Z, Thallinger GG, Wakeman JA, McFarlane RJ
Oncotarget7(23)33809-20(2016 Jun)

An inter-species protein-protein interaction network across vast evolutionary distance.
Zhong Q, Pevzner SJ, Hao T, Wang Y, Mosca R, Menche J, Taipale M, Ta?an M, Fan C, Yang X, Haley P, Murray RR, Mer F, Gebreab F, Tam S, MacWilliams A, Dricot A, Reichert P, Santhanam B, Ghamsari L, Calderwood MA, Rolland T, Charloteaux B, Lindquist S, Barab?si AL, Hill DE, Aloy P, Cusick ME, Xia Y, Roth FP, Vidal M
Molecular systems biology12(4)865(2016 Apr)

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M
Cell163(3)712-23(2015 Oct)

Identification of chimeric TSNAX-DISC1 resulting from intergenic splicing in endometrial carcinoma through high-throughput RNA sequencing.
Li N, Zheng J, Li H, Deng J, Hu M, Wu H, Li W, Li F, Lan X, Lu J, Zhou Y
Carcinogenesis35(12)2687-97(2014 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Translin and Trax control telomere-associated transcript levels in human cells in a telomere-specific fashion.
Title: Translin and Trax differentially regulate telomere-associated transcript homeostasis.

High chimeric TSNAX-DISC1 resulting from intergenic splicing is associated with endometrial carcinoma.
Title: Identification of chimeric TSNAX-DISC1 resulting from intergenic splicing in endometrial carcinoma through high-throughput RNA sequencing.

TSNAX protein is known to form a brain enriched complex with translin, that can bind single-stranded DNA and RNA through which it is involved in protein regulation.
Title: DISC1-TSNAX and DAOA genes in major depression and citalopram efficacy.

LIS1 and TSNAX genes are not associated with susceptibility to bipolar I disorder in Chinese Han population.
Title: [Association study of LIS1 and TSNAX genes with bipolar disorder in Chinese Han population].

Data show a novel role of phospholipase Cbeta1 (PLCbeta1) in gene regulation through translin-associated factor X (TRAX) association.
Title: Phospholipase C?1 is linked to RNA interference of specific genes through translin-associated factor X.

The following TSNAX gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TSNAX cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29410	NM_005999.3 Latest version!	Homo sapiens translin associated factor X (TSNAX), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
View Old Accession Versions >>
OHu29410	NM_005999.2	Homo sapiens translin associated factor X (TSNAX), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TSNAX ( NM_005999.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_005990.1 Homo sapiens translin associated factor X (TSNAX), mRNA.

Price & Availability↑

CloneID	OHu29410
Clone ID Related Accession (Same CDS sequence)	NM_005999.2 , NM_005999.3
Accession Version	NM_005999.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 873bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-28
Organism	Homo sapiens(human)
Product	translin-associated protein X
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X95073.1. On Apr 24, 2002 this sequence version replaced NM_005999.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X95073.1, SRR1660803.113889.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCAACA AAGAAGGATC AGGAGGGTTC AGGAAAAGGA AGCATGACAA TTTCCCACAT 
AACCAAAGAA GAGAAGGGAA GGATGTTAAT TCATCTTCAC CCGTGATGTT GGCCTTTAAA 
TCATTTCAGC AGGAACTTGA TGCAAGGCAT GACAAATATG AGAGACTTGT GAAACTTAGT 
CGGGATATAA CTGTTGAAAG TAAAAGGACA ATTTTTCTCC TCCATAGGAT TACAAGTGCT 
CCTGATATGG AAGATATATT GACTGAATCA GAAATTAAAT TGGATGGTGT CAGACAAAAG 
ATATTCCAGG TAGCCCAAGA GCTATCAGGG GAAGATATGC ATCAGTTCCA TCGAGCCATT 
ACTACAGGAC TACAGGAATA TGTGGAAGCT GTCTCTTTTC AACACTTCAT CAAAACACGA 
TCATTAATTA GTATGGATGA AATTAATAAA CAATTGATAT TTACGACTGA AGACAATGGG 
AAAGAAAATA AAACTCCCTC CTCTGATGCA CAGGATAAGC AGTTTGGTAC TTGGAGACTG 
AGAGTCACAC CTGTCGATTA CCTTCTGGGA GTGGCTGACT TAACTGGAGA ATTGATGCGG 
ATGTGTATTA ACAGTGTGGG GAATGGGGAC ATTGATACCC CCTTTGAAGT GAGCCAGTTT 
TTACGTCAGG TTTATGATGG GTTTTCATTC ATTGGCAACA CTGGACCTTA CGAGGTTTCT 
AAGAAGCTGT ATACCTTGAA ACAAAGTTTG GCCAAAGTGG AGAATGCTTG TTATGCCTTG 
AAAGTCAGAG GGTCAGAAAT TCCAAAACAT ATGTTGGCAG ATGTGTTTTC AGTTAAAACA 
GAAATGATAG ATCAAGAAGA GGGCATTTCT TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005990.1
CDS	159..1031
Translation	MSNKEGSGGFRKRKHDNFPHNQRREGKDVNSSSPVMLAFKSFQQELDARHDKYERLVKLSRDITVESKRTIFLLHRITSAPDMEDILTESEIKLDGVRQKIFQVAQELSGEDMHQFHRAITTGLQEYVEAVSFQHFIKTRSLISMDEINKQLIFTTEDNGKENKTPSSDAQDKQFGTWRLRVTPVDYLLGVADLTGELMRMCINSVGNGDIDTPFEVSQFLRQVYDGFSFIGNTGPYEVSKKLYTLKQSLAKVENACYALKVRGSEIPKHMLADVFSVKTEMIDQEEGIS

Target ORF information:

RefSeq Version	NM_005999.2
Organism	Homo sapiens(human)
Definition	Homo sapiens translin associated factor X (TSNAX), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005999.2

ORF Insert Sequence:

ATGAGCAACA AAGAAGGATC AGGAGGGTTC AGGAAAAGGA AGCATGACAA TTTCCCACAT 
AACCAAAGAA GAGAAGGGAA GGATGTTAAT TCATCTTCAC CCGTGATGTT GGCCTTTAAA 
TCATTTCAGC AGGAACTTGA TGCAAGGCAT GACAAATATG AGAGACTTGT GAAACTTAGT 
CGGGATATAA CTGTTGAAAG TAAAAGGACA ATTTTTCTCC TCCATAGGAT TACAAGTGCT 
CCTGATATGG AAGATATATT GACTGAATCA GAAATTAAAT TGGATGGTGT CAGACAAAAG 
ATATTCCAGG TAGCCCAAGA GCTATCAGGG GAAGATATGC ATCAGTTCCA TCGAGCCATT 
ACTACAGGAC TACAGGAATA TGTGGAAGCT GTCTCTTTTC AACACTTCAT CAAAACACGA 
TCATTAATTA GTATGGATGA AATTAATAAA CAATTGATAT TTACGACTGA AGACAATGGG 
AAAGAAAATA AAACTCCCTC CTCTGATGCA CAGGATAAGC AGTTTGGTAC TTGGAGACTG 
AGAGTCACAC CTGTCGATTA CCTTCTGGGA GTGGCTGACT TAACTGGAGA ATTGATGCGG 
ATGTGTATTA ACAGTGTGGG GAATGGGGAC ATTGATACCC CCTTTGAAGT GAGCCAGTTT 
TTACGTCAGG TTTATGATGG GTTTTCATTC ATTGGCAACA CTGGACCTTA CGAGGTTTCT 
AAGAAGCTGT ATACCTTGAA ACAAAGTTTG GCCAAAGTGG AGAATGCTTG TTATGCCTTG 
AAAGTCAGAG GGTCAGAAAT TCCAAAACAT ATGTTGGCAG ATGTGTTTTC AGTTAAAACA 
GAAATGATAG ATCAAGAAGA GGGCATTTCT TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TSNAX ( NM_005999.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005990.1 Homo sapiens translin associated factor X (TSNAX), mRNA.

Price & Availability↑

CloneID	OHu29410
Clone ID Related Accession (Same CDS sequence)	NM_005999.2 , NM_005999.3
Accession Version	NM_005999.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 873bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	translin-associated protein X
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL445524.28 and AL626763.11. On Nov 26, 2018 this sequence version replaced NM_005999.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X95073.1, SRR1660805.192954.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000366639.9/ ENSP00000355599.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGCAACA AAGAAGGATC AGGAGGGTTC AGGAAAAGGA AGCATGACAA TTTCCCACAT 
AACCAAAGAA GAGAAGGGAA GGATGTTAAT TCATCTTCAC CCGTGATGTT GGCCTTTAAA 
TCATTTCAGC AGGAACTTGA TGCAAGGCAT GACAAATATG AGAGACTTGT GAAACTTAGT 
CGGGATATAA CTGTTGAAAG TAAAAGGACA ATTTTTCTCC TCCATAGGAT TACAAGTGCT 
CCTGATATGG AAGATATATT GACTGAATCA GAAATTAAAT TGGATGGTGT CAGACAAAAG 
ATATTCCAGG TAGCCCAAGA GCTATCAGGG GAAGATATGC ATCAGTTCCA TCGAGCCATT 
ACTACAGGAC TACAGGAATA TGTGGAAGCT GTCTCTTTTC AACACTTCAT CAAAACACGA 
TCATTAATTA GTATGGATGA AATTAATAAA CAATTGATAT TTACGACTGA AGACAATGGG 
AAAGAAAATA AAACTCCCTC CTCTGATGCA CAGGATAAGC AGTTTGGTAC TTGGAGACTG 
AGAGTCACAC CTGTCGATTA CCTTCTGGGA GTGGCTGACT TAACTGGAGA ATTGATGCGG 
ATGTGTATTA ACAGTGTGGG GAATGGGGAC ATTGATACCC CCTTTGAAGT GAGCCAGTTT 
TTACGTCAGG TTTATGATGG GTTTTCATTC ATTGGCAACA CTGGACCTTA CGAGGTTTCT 
AAGAAGCTGT ATACCTTGAA ACAAAGTTTG GCCAAAGTGG AGAATGCTTG TTATGCCTTG 
AAAGTCAGAG GGTCAGAAAT TCCAAAACAT ATGTTGGCAG ATGTGTTTTC AGTTAAAACA 
GAAATGATAG ATCAAGAAGA GGGCATTTCT TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005990.1
CDS	143..1015
Translation	MSNKEGSGGFRKRKHDNFPHNQRREGKDVNSSSPVMLAFKSFQQELDARHDKYERLVKLSRDITVESKRTIFLLHRITSAPDMEDILTESEIKLDGVRQKIFQVAQELSGEDMHQFHRAITTGLQEYVEAVSFQHFIKTRSLISMDEINKQLIFTTEDNGKENKTPSSDAQDKQFGTWRLRVTPVDYLLGVADLTGELMRMCINSVGNGDIDTPFEVSQFLRQVYDGFSFIGNTGPYEVSKKLYTLKQSLAKVENACYALKVRGSEIPKHMLADVFSVKTEMIDQEEGIS

Target ORF information:

RefSeq Version	NM_005999.3
Organism	Homo sapiens(human)
Definition	Homo sapiens translin associated factor X (TSNAX), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005999.3

ORF Insert Sequence:

ATGAGCAACA AAGAAGGATC AGGAGGGTTC AGGAAAAGGA AGCATGACAA TTTCCCACAT 
AACCAAAGAA GAGAAGGGAA GGATGTTAAT TCATCTTCAC CCGTGATGTT GGCCTTTAAA 
TCATTTCAGC AGGAACTTGA TGCAAGGCAT GACAAATATG AGAGACTTGT GAAACTTAGT 
CGGGATATAA CTGTTGAAAG TAAAAGGACA ATTTTTCTCC TCCATAGGAT TACAAGTGCT 
CCTGATATGG AAGATATATT GACTGAATCA GAAATTAAAT TGGATGGTGT CAGACAAAAG 
ATATTCCAGG TAGCCCAAGA GCTATCAGGG GAAGATATGC ATCAGTTCCA TCGAGCCATT 
ACTACAGGAC TACAGGAATA TGTGGAAGCT GTCTCTTTTC AACACTTCAT CAAAACACGA 
TCATTAATTA GTATGGATGA AATTAATAAA CAATTGATAT TTACGACTGA AGACAATGGG 
AAAGAAAATA AAACTCCCTC CTCTGATGCA CAGGATAAGC AGTTTGGTAC TTGGAGACTG 
AGAGTCACAC CTGTCGATTA CCTTCTGGGA GTGGCTGACT TAACTGGAGA ATTGATGCGG 
ATGTGTATTA ACAGTGTGGG GAATGGGGAC ATTGATACCC CCTTTGAAGT GAGCCAGTTT 
TTACGTCAGG TTTATGATGG GTTTTCATTC ATTGGCAACA CTGGACCTTA CGAGGTTTCT 
AAGAAGCTGT ATACCTTGAA ACAAAGTTTG GCCAAAGTGG AGAATGCTTG TTATGCCTTG 
AAAGTCAGAG GGTCAGAAAT TCCAAAACAT ATGTTGGCAG ATGTGTTTTC AGTTAAAACA 
GAAATGATAG ATCAAGAAGA GGGCATTTCT TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Translin and Trax differentially regulate telomere-associated transcript homeostasis.
Oncotarget7(23)33809-20(2016 Jun)
Gomez-Escobar N,Almobadel N,Alzahrani O,Feichtinger J,Planells-Palop V,Alshehri Z,Thallinger GG,Wakeman JA,McFarlane RJ

An inter-species protein-protein interaction network across vast evolutionary distance.
Molecular systems biology12(4)865(2016 Apr)
Zhong Q,Pevzner SJ,Hao T,Wang Y,Mosca R,Menche J,Taipale M,Ta?an M,Fan C,Yang X,Haley P,Murray RR,Mer F,Gebreab F,Tam S,MacWilliams A,Dricot A,Reichert P,Santhanam B,Ghamsari L,Calderwood MA,Rolland T,Charloteaux B,Lindquist S,Barab?si AL,Hill DE,Aloy P,Cusick ME,Xia Y,Roth FP,Vidal M

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Cell163(3)712-23(2015 Oct)
Hein MY,Hubner NC,Poser I,Cox J,Nagaraj N,Toyoda Y,Gak IA,Weisswange I,Mansfeld J,Buchholz F,Hyman AA,Mann M

Identification of chimeric TSNAX-DISC1 resulting from intergenic splicing in endometrial carcinoma through high-throughput RNA sequencing.
Carcinogenesis35(12)2687-97(2014 Dec)
Li N,Zheng J,Li H,Deng J,Hu M,Wu H,Li W,Li F,Lan X,Lu J,Zhou Y

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TSNAX cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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