TSHB cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TSHB
Entrez Gene ID	7252
Full Name	thyroid stimulating hormone beta
Synonyms	TSH-B,TSH-BETA
General protein information	Preferred Names thyroid stimulating hormone beta Names thyrotropin subunit beta thyrotropin beta chain
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p13.2
Summary	The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Mutations in this gene are associated with congenital central and secondary hypothyroidism and Hashimoto's thyroiditis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013].
Disorder MIM:	188540
Disorder Html:	Hypothyroidism, congenital, nongoitrous 4, 275100 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000549.4	NP_000540.2	thyrotropin subunit beta isoform 1 precursor
NM_000549.5	NP_000540.2	thyrotropin subunit beta isoform 1 precursor
NM_001277991.1	NP_001264920.1	thyrotropin subunit beta isoform 2
XM_011542065.2	XP_011540367.1	thyrotropin subunit beta isoform X1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	TSHB	NP_001003290.1
Bos taurus (cattle)	TSHB	NP_776630.1
Rattus norvegicus (Norway rat)	Tshb	NP_037248.2
Homo sapiens (human)	TSHB	NP_000540.2
	TSHB	XP_001111873.2
Danio rerio (zebrafish)	tshb	NP_852471.1
Xenopus tropicalis (tropical clawed frog)	LOC100496349	XP_004910773.1
Pan troglodytes (chimpanzee)	TSHB	XP_001160337.1
Mus musculus (house mouse)	Tshb	NP_001159411.1
Gallus gallus (chicken)	TSHB	NP_990394.1
Danio rerio (zebrafish)	LOC100001596	XP_001341563.1

Gene Ontology
Bibliography

Related articles in PubMed

Moreno-Navarrete JM, Moreno M, Ortega F, Xifra G, Hong S, Asara JM, Serrano JCE, Jov? M, Pissios P, Bl?her M, Ricart W, Portero-Otin M, Fern?ndez-Real JM
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(10)4482-4491(2017 Oct)

Congenital Central Hypothyroidism Caused by a Novel Thyroid-Stimulating Hormone-Beta Subunit Gene Mutation in Two Siblings.
?zhan B, Boz Anla? ?, Sar?kepe B, Albuz B, Semerci G?nd?z N
Journal of clinical research in pediatric endocrinology9(3)278-282(2017 Sep)

Serum Macro TSH Level is Associated with Sleep Quality in Patients with Cardiovascular Risks - HSCAA Study.
Kadoya M, Koyama S, Morimoto A, Miyoshi A, Kakutani M, Hamamoto K, Kurajoh M, Shoji T, Moriwaki Y, Koshiba M, Yamamoto T, Inaba M, Namba M, Koyama H
Scientific reports744387(2017 Mar)

A newly identified TSH? splice variant is involved in the pathology of Hashimoto's thyroiditis.
Liu C, Li L, Ying F, Xu C, Zang X, Gao Z
Molecular biology reports39(12)10019-30(2012 Dec)

A novel thyroid stimulating hormone beta-subunit isoform in human pituitary, peripheral blood leukocytes, and thyroid.
Schaefer JS, Klein JR
General and comparative endocrinology162(3)241-4(2009 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

results provide novel evidence of TSHB as a paracrine factor that is modulated in parallel with cholesterol metabolism in human adipose tissue

In the context of metabolic syndrome, a higher TSH within the euthyroid range confers an increased leptin/adiponectin ratio, a proposed marker of atherosclerosis susceptibility and adipocyte dysfunction.
Title: Increased leptin/adiponectin ratio relates to low-normal thyroid function in metabolic syndrome.

The serum levels of IL-8, MIP-1 alpha, MIP-1 beta, MMP-8, Resistin, FLRG, and BCAM were significantly higher in breast cancer patients, but LAP and TSH-beta levels were lower.
Title: Serum cytokine profile in patients with breast cancer.

In hyperthyroidism, bone marrow resident macrophages have the potential to exert enhanced osteoprotective effects by oversecreting a TSH-beta splice variant.
Title: T3 Regulates a Human Macrophage-Derived TSH-? Splice Variant: Implications for Human Bone Biology.

the distribution of 1(st) trimester TSH and evaluate its association with perinatal outcomes and future development of maternal thyrotoxicosis, is reported.
Title: Maternal First Trimester TSH Concentrations: Do They Affect Perinatal and Endocrine Outcomes?

The following TSHB gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TSHB cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22982	NM_000549.5 Latest version!	Homo sapiens thyroid stimulating hormone subunit beta (TSHB), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu22982	XM_011542065.2 Latest version!	Homo sapiens thyroid stimulating hormone subunit beta (TSHB), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu01599	NM_001277991.1 Latest version!	Homo sapiens thyroid stimulating hormone subunit beta (TSHB), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OHu22982	NM_000549.4	Homo sapiens thyroid stimulating hormone subunit beta (TSHB), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TSHB ( NM_000549.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000540.2 Homo sapiens thyroid stimulating hormone subunit beta (TSHB), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22982
Clone ID Related Accession (Same CDS sequence)	NM_000549.4 , NM_000549.5 , XM_011542065.2
Accession Version	NM_000549.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 417bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-09
Organism	Homo sapiens(human)
Product	thyrotropin subunit beta isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL109660.14. This sequence is a reference standard in the RefSeqGene project. On May 4, 2013 this sequence version replaced NM_000549.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1, also known as native TSH-beta). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments and data in published reports (PMID 3243440). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: BG202613.1, BC069298.1 [ECO:0000331] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGACTGCTC TCTTTCTGAT GTCCATGCTT TTTGGCCTTA CATGTGGGCA AGCGATGTCT 
TTTTGTATTC CAACTGAGTA TACAATGCAC ATCGAAAGGA GAGAGTGTGC TTATTGCCTA 
ACCATCAACA CCACCATCTG TGCTGGATAT TGTATGACAC GGGATATCAA TGGCAAACTG 
TTTCTTCCCA AATATGCTCT GTCCCAGGAT GTTTGCACAT ATAGAGACTT CATCTACAGG 
ACTGTAGAAA TACCAGGATG CCCACTCCAT GTTGCTCCCT ATTTTTCCTA TCCTGTTGCT 
TTAAGCTGTA AGTGTGGCAA GTGCAATACT GACTATAGTG ACTGCATACA TGAAGCCATC 
AAGACAAACT ACTGTACCAA ACCTCAGAAG TCTTATCTGG TAGGATTTTC TGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000540.2
CDS	39..455
Translation	MTALFLMSMLFGLTCGQAMSFCIPTEYTMHIERRECAYCLTINTTICAGYCMTRDINGKLFLPKYALSQDVCTYRDFIYRTVEIPGCPLHVAPYFSYPVALSCKCGKCNTDYSDCIHEAIKTNYCTKPQKSYLVGFSV

Target ORF information:

RefSeq Version	NM_000549.4
Organism	Homo sapiens(human)
Definition	Homo sapiens thyroid stimulating hormone subunit beta (TSHB), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000549.4

ORF Insert Sequence:

ATGACTGCTC TCTTTCTGAT GTCCATGCTT TTTGGCCTTA CATGTGGGCA AGCGATGTCT 
TTTTGTATTC CAACTGAGTA TACAATGCAC ATCGAAAGGA GAGAGTGTGC TTATTGCCTA 
ACCATCAACA CCACCATCTG TGCTGGATAT TGTATGACAC GGGATATCAA TGGCAAACTG 
TTTCTTCCCA AATATGCTCT GTCCCAGGAT GTTTGCACAT ATAGAGACTT CATCTACAGG 
ACTGTAGAAA TACCAGGATG CCCACTCCAT GTTGCTCCCT ATTTTTCCTA TCCTGTTGCT 
TTAAGCTGTA AGTGTGGCAA GTGCAATACT GACTATAGTG ACTGCATACA TGAAGCCATC 
AAGACAAACT ACTGTACCAA ACCTCAGAAG TCTTATCTGG TAGGATTTTC TGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TSHB ( NM_000549.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_000540.2 Homo sapiens thyroid stimulating hormone subunit beta (TSHB), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22982
Clone ID Related Accession (Same CDS sequence)	NM_000549.4 , NM_000549.5 , XM_011542065.2
Accession Version	NM_000549.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 417bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-29
Organism	Homo sapiens(human)
Product	thyrotropin subunit beta isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL109660.14. This sequence is a reference standard in the RefSeqGene project. On Jul 26, 2019 this sequence version replaced NM_000549.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1, also known as native TSH-beta). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments and data in published reports (PMID 3243440). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: BG202613.1, BC069298.1 [ECO:0000331] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGACTGCTC TCTTTCTGAT GTCCATGCTT TTTGGCCTTA CATGTGGGCA AGCGATGTCT 
TTTTGTATTC CAACTGAGTA TACAATGCAC ATCGAAAGGA GAGAGTGTGC TTATTGCCTA 
ACCATCAACA CCACCATCTG TGCTGGATAT TGTATGACAC GGGATATCAA TGGCAAACTG 
TTTCTTCCCA AATATGCTCT GTCCCAGGAT GTTTGCACAT ATAGAGACTT CATCTACAGG 
ACTGTAGAAA TACCAGGATG CCCACTCCAT GTTGCTCCCT ATTTTTCCTA TCCTGTTGCT 
TTAAGCTGTA AGTGTGGCAA GTGCAATACT GACTATAGTG ACTGCATACA TGAAGCCATC 
AAGACAAACT ACTGTACCAA ACCTCAGAAG TCTTATCTGG TAGGATTTTC TGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000540.2
CDS	37..453
Translation	MTALFLMSMLFGLTCGQAMSFCIPTEYTMHIERRECAYCLTINTTICAGYCMTRDINGKLFLPKYALSQDVCTYRDFIYRTVEIPGCPLHVAPYFSYPVALSCKCGKCNTDYSDCIHEAIKTNYCTKPQKSYLVGFSV

Target ORF information:

RefSeq Version	NM_000549.5
Organism	Homo sapiens(human)
Definition	Homo sapiens thyroid stimulating hormone subunit beta (TSHB), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000549.5

ORF Insert Sequence:

ATGACTGCTC TCTTTCTGAT GTCCATGCTT TTTGGCCTTA CATGTGGGCA AGCGATGTCT 
TTTTGTATTC CAACTGAGTA TACAATGCAC ATCGAAAGGA GAGAGTGTGC TTATTGCCTA 
ACCATCAACA CCACCATCTG TGCTGGATAT TGTATGACAC GGGATATCAA TGGCAAACTG 
TTTCTTCCCA AATATGCTCT GTCCCAGGAT GTTTGCACAT ATAGAGACTT CATCTACAGG 
ACTGTAGAAA TACCAGGATG CCCACTCCAT GTTGCTCCCT ATTTTTCCTA TCCTGTTGCT 
TTAAGCTGTA AGTGTGGCAA GTGCAATACT GACTATAGTG ACTGCATACA TGAAGCCATC 
AAGACAAACT ACTGTACCAA ACCTCAGAAG TCTTATCTGG TAGGATTTTC TGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TSHB ( XM_011542065.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011540367.1 Homo sapiens thyroid stimulating hormone subunit beta (TSHB), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu22982
Clone ID Related Accession (Same CDS sequence)	NM_000549.4 , NM_000549.5 , XM_011542065.2
Accession Version	XM_011542065.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 417bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	thyrotropin subunit beta isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011542065.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACTGCTC TCTTTCTGAT GTCCATGCTT TTTGGCCTTA CATGTGGGCA AGCGATGTCT 
TTTTGTATTC CAACTGAGTA TACAATGCAC ATCGAAAGGA GAGAGTGTGC TTATTGCCTA 
ACCATCAACA CCACCATCTG TGCTGGATAT TGTATGACAC GGGATATCAA TGGCAAACTG 
TTTCTTCCCA AATATGCTCT GTCCCAGGAT GTTTGCACAT ATAGAGACTT CATCTACAGG 
ACTGTAGAAA TACCAGGATG CCCACTCCAT GTTGCTCCCT ATTTTTCCTA TCCTGTTGCT 
TTAAGCTGTA AGTGTGGCAA GTGCAATACT GACTATAGTG ACTGCATACA TGAAGCCATC 
AAGACAAACT ACTGTACCAA ACCTCAGAAG TCTTATCTGG TAGGATTTTC TGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011540367.1
CDS	78..494
Translation	MTALFLMSMLFGLTCGQAMSFCIPTEYTMHIERRECAYCLTINTTICAGYCMTRDINGKLFLPKYALSQDVCTYRDFIYRTVEIPGCPLHVAPYFSYPVALSCKCGKCNTDYSDCIHEAIKTNYCTKPQKSYLVGFSV

Target ORF information:

RefSeq Version	XM_011542065.2
Organism	Homo sapiens(human)
Definition	Homo sapiens thyroid stimulating hormone subunit beta (TSHB), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011542065.2

ORF Insert Sequence:

ATGACTGCTC TCTTTCTGAT GTCCATGCTT TTTGGCCTTA CATGTGGGCA AGCGATGTCT 
TTTTGTATTC CAACTGAGTA TACAATGCAC ATCGAAAGGA GAGAGTGTGC TTATTGCCTA 
ACCATCAACA CCACCATCTG TGCTGGATAT TGTATGACAC GGGATATCAA TGGCAAACTG 
TTTCTTCCCA AATATGCTCT GTCCCAGGAT GTTTGCACAT ATAGAGACTT CATCTACAGG 
ACTGTAGAAA TACCAGGATG CCCACTCCAT GTTGCTCCCT ATTTTTCCTA TCCTGTTGCT 
TTAAGCTGTA AGTGTGGCAA GTGCAATACT GACTATAGTG ACTGCATACA TGAAGCCATC 
AAGACAAACT ACTGTACCAA ACCTCAGAAG TCTTATCTGG TAGGATTTTC TGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TSHB ( NM_001277991.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001264920.1 Homo sapiens thyroid stimulating hormone subunit beta (TSHB), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu01599
Clone ID Related Accession (Same CDS sequence)	NM_001277991.1
Accession Version	NM_001277991.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 282bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Homo sapiens(human)
Product	thyrotropin subunit beta isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL109660.14. Transcript Variant: This variant (2) initiates translation at an alternate start codon and contains an intronless coding sequence, compared to variant 1. The encoded isoform (2, also known as novel TSH-beta) has a distinct N-terminus and is shorter than isoform 1. This variant is based on experimental data in PMIDs 19364510 and 22752807. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on data in published reports (PMIDs 19364510 and 22752807). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

ATGCTCTCTT TTCTGTTCTT TCCCCAGGAT ATCAATGGCA AACTGTTTCT TCCCAAATAT 
GCTCTGTCCC AGGATGTTTG CACATATAGA GACTTCATCT ACAGGACTGT AGAAATACCA 
GGATGCCCAC TCCATGTTGC TCCCTATTTT TCCTATCCTG TTGCTTTAAG CTGTAAGTGT 
GGCAAGTGCA ATACTGACTA TAGTGACTGC ATACATGAAG CCATCAAGAC AAACTACTGT 
ACCAAACCTC AGAAGTCTTA TCTGGTAGGA TTTTCTGTCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001264920.1
CDS	1..282
Translation	MLSFLFFPQDINGKLFLPKYALSQDVCTYRDFIYRTVEIPGCPLHVAPYFSYPVALSCKCGKCNTDYSDCIHEAIKTNYCTKPQKSYLVGFSV

Target ORF information:

RefSeq Version	NM_001277991.1
Organism	Homo sapiens(human)
Definition	Homo sapiens thyroid stimulating hormone subunit beta (TSHB), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001277991.1

ORF Insert Sequence:

ATGCTCTCTT TTCTGTTCTT TCCCCAGGAT ATCAATGGCA AACTGTTTCT TCCCAAATAT 
GCTCTGTCCC AGGATGTTTG CACATATAGA GACTTCATCT ACAGGACTGT AGAAATACCA 
GGATGCCCAC TCCATGTTGC TCCCTATTTT TCCTATCCTG TTGCTTTAAG CTGTAAGTGT 
GGCAAGTGCA ATACTGACTA TAGTGACTGC ATACATGAAG CCATCAAGAC AAACTACTGT 
ACCAAACCTC AGAAGTCTTA TCTGGTAGGA TTTTCTGTCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(10)4482-4491(2017 Oct)
Moreno-Navarrete JM,Moreno M,Ortega F,Xifra G,Hong S,Asara JM,Serrano JCE,Jov? M,Pissios P,Bl?her M,Ricart W,Portero-Otin M,Fern?ndez-Real JM

Congenital Central Hypothyroidism Caused by a Novel Thyroid-Stimulating Hormone-Beta Subunit Gene Mutation in Two Siblings.
Journal of clinical research in pediatric endocrinology9(3)278-282(2017 Sep)
?zhan B,Boz Anla? ?,Sar?kepe B,Albuz B,Semerci G?nd?z N

Serum Macro TSH Level is Associated with Sleep Quality in Patients with Cardiovascular Risks - HSCAA Study.
Scientific reports744387(2017 Mar)
Kadoya M,Koyama S,Morimoto A,Miyoshi A,Kakutani M,Hamamoto K,Kurajoh M,Shoji T,Moriwaki Y,Koshiba M,Yamamoto T,Inaba M,Namba M,Koyama H

A newly identified TSH? splice variant is involved in the pathology of Hashimoto's thyroiditis.
Molecular biology reports39(12)10019-30(2012 Dec)
Liu C,Li L,Ying F,Xu C,Zang X,Gao Z

A novel thyroid stimulating hormone beta-subunit isoform in human pituitary, peripheral blood leukocytes, and thyroid.
General and comparative endocrinology162(3)241-4(2009 Jul)
Schaefer JS,Klein JR

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TSHB cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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