TRIP6 cDNA ORF clone, Homo sapiens(Human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TRIP6
Entrez Gene ID	7205
Full Name	thyroid hormone receptor interactor 6
Synonyms	OIP-1,OIP1,TRIP-6,TRIP6i2,ZRP-1
General protein information	Preferred Names thyroid hormone receptor interactor 6 Names thyroid receptor-interacting protein 6 OPA-interacting protein 1 TR-interacting protein 6 thyroid hormone receptor interacting protein 6 zyxin related protein 1
Gene Type	protein-coding
Organism	Homo sapiens(Human)
Genome	Chromosome: 7 Map Location: 7q22.1
Summary	This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008].
Disorder MIM:	602933

mRNA and Protein(s)

mRNA	Protein	Name
NM_003302.2	NP_003293.2	thyroid receptor-interacting protein 6
NM_003302.3	NP_003293.2	thyroid receptor-interacting protein 6
XM_011516545.1	XP_011514847.1	thyroid receptor-interacting protein 6 isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	TRIP6	NP_001233552.1
Canis lupus familiaris (dog)	TRIP6	XP_536859.1
Bos taurus (cattle)	TRIP6	NP_001030546.1
Homo sapiens (human)	TRIP6	NP_003293.2
Mus musculus (house mouse)	Trip6	NP_035769.1
Rattus norvegicus (Norway rat)	Trip6	NP_001121042.1
Danio rerio (zebrafish)	LOC792697	XP_005172284.1

Gene Ontology
Bibliography

Related articles in PubMed

TRIP6 inhibits Hippo signaling in response to tension at adherens junctions.
Dutta S, Mana-Capelli S, Paramasivam M, Dasgupta I, Cirka H, Billiar K, McCollum D
EMBO reports(2017 Dec)

TRIP6 promotes cell proliferation in hepatocellular carcinoma via suppression of FOXO3a.
Zhao W, Dai Y, Dai T, Xie T, Su X, Li J, Zhou X, Meng K, Zhao X
Biochemical and biophysical research communications494(3-4)594-601(2017 12)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

An inter-species protein-protein interaction network across vast evolutionary distance.
Zhong Q, Pevzner SJ, Hao T, Wang Y, Mosca R, Menche J, Taipale M, Ta?an M, Fan C, Yang X, Haley P, Murray RR, Mer F, Gebreab F, Tam S, MacWilliams A, Dricot A, Reichert P, Santhanam B, Ghamsari L, Calderwood MA, Rolland T, Charloteaux B, Lindquist S, Barab?si AL, Hill DE, Aloy P, Cusick ME, Xia Y, Roth FP, Vidal M
Molecular systems biology12(4)865(2016 Apr)

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T, Richardson A, Sun S, Yang F, Shen YA, Murray RR, Spirohn K, Begg BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, Zhong Q, Trigg SA, Tam S, Ghamsari L, Sahni N, Yi S, Rodriguez MD, Balcha D, Tan G, Costanzo M, Andrews B, Boone C, Zhou XJ, Salehi-Ashtiani K, Charloteaux B, Chen AA, Calderwood MA, Aloy P, Roth FP, Hill DE, Iakoucheva LM, Xia Y, Vidal M
Cell164(4)805-17(2016 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Taken together, these findings showed that TRIP6 plays an important role in promoting HCC cells proliferation and may serve as a novel prognostic biomarker and therapeutic target in HCC.
Title: TRIP6 promotes cell proliferation in hepatocellular carcinoma via suppression of FOXO3a.

TRIP6 promotes tumor proliferation and reverses cell adhesion-mediated drug resistance via regulating nuclear p27(Kip1) expression in non-Hodgkin's lymphoma
Title: Overexpression of TRIP6 promotes tumor proliferation and reverses cell adhesion-mediated drug resistance (CAM-DR) via regulating nuclear p27(Kip1) expression in non-Hodgkin's lymphoma.

the Trip6-GRIP1-myosin VI interaction and its regulation on F-actin network play a significant role in dendritic morphogenesis
Title: Trip6 promotes dendritic morphogenesis through dephosphorylated GRIP1-dependent myosin VI and F-actin organization.

TRIP6 acts, in contrast to Zyxin, as an oncogene that partially accounts for the autonomous migratory, invasive and proliferative properties of Ewing's sarcoma cells.
Title: The Zyxin-related protein thyroid receptor interacting protein 6 (TRIP6) is overexpressed in Ewing's sarcoma and promotes migration, invasion and cell growth.

TRIP6 is involved in the regulation of nasopharyngeal carcinoma cell motility, and phosphorylation of tyrosine 55 residue plays an important regulatory role for this event
Title: Characterization of TRIP6-dependent nasopharyngeal cancer cell migration.

The following TRIP6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TRIP6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13308	NM_003302.3 Latest version!	Homo sapiens thyroid hormone receptor interactor 6 (TRIP6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
OHu13308	XM_011516545.1 Latest version!	Homo sapiens thyroid hormone receptor interactor 6 (TRIP6), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
View Old Accession Versions >>
OHu13308	NM_003302.2	Homo sapiens thyroid hormone receptor interactor 6 (TRIP6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TRIP6 ( NM_003302.2 ) cDNA ORF clone, Homo sapiens(Human) -> NP_003293.2 Homo sapiens thyroid hormone receptor interactor 6 (TRIP6), mRNA.

Price & Availability↑

CloneID	OHu13308
Clone ID Related Accession (Same CDS sequence)	NM_003302.2 , NM_003302.3 , XM_011516545.1
Accession Version	NM_003302.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1431bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-29
Organism	Homo sapiens(human)
Product	thyroid receptor-interacting protein 6
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM800083.1 and BC004999.1. On Apr 7, 2006 this sequence version replaced NM_003302.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.71003.1, AF000974.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCGGGGC CCACCTGGCT GCCCCCGAAG CAGCCGGAGC CCGCCAGAGC CCCTCAGGGG 
AGGGCGATCC CCCGCGGCAC CCCGGGGCCA CCACCGGCCC ACGGAGCAGC ACTCCAGCCC 
CACCCCAGGG TCAATTTTTG CCCCCTTCCA TCTGAGCAGT GTTACCAGGC CCCAGGGGGA 
CCGGAGGATC GGGGGCCGGC GTGGGTGGGG TCCCATGGAG TACTCCAGCA CACGCAGGGG 
CTCCCTGCAG ACAGGGGGGG CCTTCGCCCT GGAAGCCTGG ACGCCGAGAT AGACTTGCTG 
AGCAGCACGC TGGCCGAGCT GAATGGGGGT CGGGGTCATG CGTCACGGCG ACCAGACCGA 
CAGGCATATG AGCCCCCGCC ACCTCCTGCC TACCGCACGG GCTCCCTGAA GCCAAATCCA 
GCCTCGCCGC TCCCAGCGTC TCCCTATGGG GGCCCCACTC CAGCCTCTTA CACTACCGCC 
AGCACCCCGG CTGGCCCAGC CTTCCCCGTG CAAGTGAAGG TGGCACAGCC AGTGAGGGGC 
TGCGGCCCAC CCAGGCGGGG AGCCTCTCAG GCCTCTGGGC CCCTCCCGGG CCCCCACTTT 
CCTCTCCCAG GCCGAGGTGA AGTCTGGGGG CCTGGCTATA GGAGCCAGAG AGAGCCAGGG 
CCAGGGGCCA AAGAGGAAGC TGCTGGGGTC TCTGGCCCTG CAGGAAGAGG AAGAGGAGGC 
GAGCACGGGC CCCAGGTGCC CCTGAGCCAG CCTCCAGAGG ATGAGCTGGA TAGGCTGACG 
AAGAAGCTGG TTCACGACAT GAACCACCCG CCCAGCGGGG AGTACTTTGG CCAGTGTGGT 
GGCTGCGGAG AAGATGTGGT TGGGGATGGG GCTGGGGTTG TGGCCCTTGA TCGCGTCTTT 
CACGTGGGCT GCTTTGTATG TTCTACATGC CGGGCCCAGC TTCGCGGCCA GCATTTCTAC 
GCCGTGGAGA GGAGGGCATA TTGCGAGGGC TGCTACGTGG CCACCCTGGA GAAATGTGCC 
ACGTGCTCCC AGCCCATCCT GGACCGGATC CTGCGGGCTA TGGGGAAGGC CTACCACCCT 
GGCTGCTTCA CCTGCGTGGT GTGTCACCGC GGCCTCGACG GCATCCCCTT CACAGTGGAT 
GCTACGAGCC AGATCCACTG CATTGAGGAC TTTCACAGGA AGTTTGCCCC AAGATGCTCA 
GTGTGCGGTG GGGCCATAAT GCCTGAGCCA GGTCAGGAGG AGACTGTGAG AATTGTTGCT 
CTGGATCGAA GTTTTCACAT TGGCTGTTAC AAGTGCGAGG AGTGTGGGCT GCTGCTCTCC 
TCTGAGGGCG AGTGTCAGGG CTGCTACCCG CTGGATGGGC ACATCTTGTG CAAGGCCTGC 
AGCGCCTGGC GCATCCAGGA GCTCTCAGCC ACCGTCACCA CTGACTGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003293.2
CDS	171..1601
Translation	MSGPTWLPPKQPEPARAPQGRAIPRGTPGPPPAHGAALQPHPRVNFCPLPSEQCYQAPGGPEDRGPAWVGSHGVLQHTQGLPADRGGLRPGSLDAEIDLLSSTLAELNGGRGHASRRPDRQAYEPPPPPAYRTGSLKPNPASPLPASPYGGPTPASYTTASTPAGPAFPVQVKVAQPVRGCGPPRRGASQASGPLPGPHFPLPGRGEVWGPGYRSQREPGPGAKEEAAGVSGPAGRGRGGEHGPQVPLSQPPEDELDRLTKKLVHDMNHPPSGEYFGQCGGCGEDVVGDGAGVVALDRVFHVGCFVCSTCRAQLRGQHFYAVERRAYCEGCYVATLEKCATCSQPILDRILRAMGKAYHPGCFTCVVCHRGLDGIPFTVDATSQIHCIEDFHRKFAPRCSVCGGAIMPEPGQEETVRIVALDRSFHIGCYKCEECGLLLSSEGECQGCYPLDGHILCKACSAWRIQELSATVTTDC

Target ORF information:

RefSeq Version	NM_003302.2
Organism	Homo sapiens(human)
Definition	Homo sapiens thyroid hormone receptor interactor 6 (TRIP6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003302.2

ORF Insert Sequence:

ATGTCGGGGC CCACCTGGCT GCCCCCGAAG CAGCCGGAGC CCGCCAGAGC CCCTCAGGGG 
AGGGCGATCC CCCGCGGCAC CCCGGGGCCA CCACCGGCCC ACGGAGCAGC ACTCCAGCCC 
CACCCCAGGG TCAATTTTTG CCCCCTTCCA TCTGAGCAGT GTTACCAGGC CCCAGGGGGA 
CCGGAGGATC GGGGGCCGGC GTGGGTGGGG TCCCATGGAG TACTCCAGCA CACGCAGGGG 
CTCCCTGCAG ACAGGGGGGG CCTTCGCCCT GGAAGCCTGG ACGCCGAGAT AGACTTGCTG 
AGCAGCACGC TGGCCGAGCT GAATGGGGGT CGGGGTCATG CGTCACGGCG ACCAGACCGA 
CAGGCATATG AGCCCCCGCC ACCTCCTGCC TACCGCACGG GCTCCCTGAA GCCAAATCCA 
GCCTCGCCGC TCCCAGCGTC TCCCTATGGG GGCCCCACTC CAGCCTCTTA CACTACCGCC 
AGCACCCCGG CTGGCCCAGC CTTCCCCGTG CAAGTGAAGG TGGCACAGCC AGTGAGGGGC 
TGCGGCCCAC CCAGGCGGGG AGCCTCTCAG GCCTCTGGGC CCCTCCCGGG CCCCCACTTT 
CCTCTCCCAG GCCGAGGTGA AGTCTGGGGG CCTGGCTATA GGAGCCAGAG AGAGCCAGGG 
CCAGGGGCCA AAGAGGAAGC TGCTGGGGTC TCTGGCCCTG CAGGAAGAGG AAGAGGAGGC 
GAGCACGGGC CCCAGGTGCC CCTGAGCCAG CCTCCAGAGG ATGAGCTGGA TAGGCTGACG 
AAGAAGCTGG TTCACGACAT GAACCACCCG CCCAGCGGGG AGTACTTTGG CCAGTGTGGT 
GGCTGCGGAG AAGATGTGGT TGGGGATGGG GCTGGGGTTG TGGCCCTTGA TCGCGTCTTT 
CACGTGGGCT GCTTTGTATG TTCTACATGC CGGGCCCAGC TTCGCGGCCA GCATTTCTAC 
GCCGTGGAGA GGAGGGCATA TTGCGAGGGC TGCTACGTGG CCACCCTGGA GAAATGTGCC 
ACGTGCTCCC AGCCCATCCT GGACCGGATC CTGCGGGCTA TGGGGAAGGC CTACCACCCT 
GGCTGCTTCA CCTGCGTGGT GTGTCACCGC GGCCTCGACG GCATCCCCTT CACAGTGGAT 
GCTACGAGCC AGATCCACTG CATTGAGGAC TTTCACAGGA AGTTTGCCCC AAGATGCTCA 
GTGTGCGGTG GGGCCATAAT GCCTGAGCCA GGTCAGGAGG AGACTGTGAG AATTGTTGCT 
CTGGATCGAA GTTTTCACAT TGGCTGTTAC AAGTGCGAGG AGTGTGGGCT GCTGCTCTCC 
TCTGAGGGCG AGTGTCAGGG CTGCTACCCG CTGGATGGGC ACATCTTGTG CAAGGCCTGC 
AGCGCCTGGC GCATCCAGGA GCTCTCAGCC ACCGTCACCA CTGACTGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TRIP6 ( NM_003302.3 ) cDNA ORF clone, Homo sapiens(Human) -> NP_003293.2 Homo sapiens thyroid hormone receptor interactor 6 (TRIP6), mRNA.

Price & Availability↑

CloneID	OHu13308
Clone ID Related Accession (Same CDS sequence)	NM_003302.2 , NM_003302.3 , XM_011516545.1
Accession Version	NM_003302.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1431bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Homo sapiens(human)
Product	thyroid receptor-interacting protein 6
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM800083.1 and BC004999.1. On Nov 23, 2018 this sequence version replaced NM_003302.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.193113.1, SRR3476690.676481.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000200457.9/ ENSP00000200457.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCGGGGC CCACCTGGCT GCCCCCGAAG CAGCCGGAGC CCGCCAGAGC CCCTCAGGGG 
AGGGCGATCC CCCGCGGCAC CCCGGGGCCA CCACCGGCCC ACGGAGCAGC ACTCCAGCCC 
CACCCCAGGG TCAATTTTTG CCCCCTTCCA TCTGAGCAGT GTTACCAGGC CCCAGGGGGA 
CCGGAGGATC GGGGGCCGGC GTGGGTGGGG TCCCATGGAG TACTCCAGCA CACGCAGGGG 
CTCCCTGCAG ACAGGGGGGG CCTTCGCCCT GGAAGCCTGG ACGCCGAGAT AGACTTGCTG 
AGCAGCACGC TGGCCGAGCT GAATGGGGGT CGGGGTCATG CGTCACGGCG ACCAGACCGA 
CAGGCATATG AGCCCCCGCC ACCTCCTGCC TACCGCACGG GCTCCCTGAA GCCAAATCCA 
GCCTCGCCGC TCCCAGCGTC TCCCTATGGG GGCCCCACTC CAGCCTCTTA CACTACCGCC 
AGCACCCCGG CTGGCCCAGC CTTCCCCGTG CAAGTGAAGG TGGCACAGCC AGTGAGGGGC 
TGCGGCCCAC CCAGGCGGGG AGCCTCTCAG GCCTCTGGGC CCCTCCCGGG CCCCCACTTT 
CCTCTCCCAG GCCGAGGTGA AGTCTGGGGG CCTGGCTATA GGAGCCAGAG AGAGCCAGGG 
CCAGGGGCCA AAGAGGAAGC TGCTGGGGTC TCTGGCCCTG CAGGAAGAGG AAGAGGAGGC 
GAGCACGGGC CCCAGGTGCC CCTGAGCCAG CCTCCAGAGG ATGAGCTGGA TAGGCTGACG 
AAGAAGCTGG TTCACGACAT GAACCACCCG CCCAGCGGGG AGTACTTTGG CCAGTGTGGT 
GGCTGCGGAG AAGATGTGGT TGGGGATGGG GCTGGGGTTG TGGCCCTTGA TCGCGTCTTT 
CACGTGGGCT GCTTTGTATG TTCTACATGC CGGGCCCAGC TTCGCGGCCA GCATTTCTAC 
GCCGTGGAGA GGAGGGCATA TTGCGAGGGC TGCTACGTGG CCACCCTGGA GAAATGTGCC 
ACGTGCTCCC AGCCCATCCT GGACCGGATC CTGCGGGCTA TGGGGAAGGC CTACCACCCT 
GGCTGCTTCA CCTGCGTGGT GTGTCACCGC GGCCTCGACG GCATCCCCTT CACAGTGGAT 
GCTACGAGCC AGATCCACTG CATTGAGGAC TTTCACAGGA AGTTTGCCCC AAGATGCTCA 
GTGTGCGGTG GGGCCATAAT GCCTGAGCCA GGTCAGGAGG AGACTGTGAG AATTGTTGCT 
CTGGATCGAA GTTTTCACAT TGGCTGTTAC AAGTGCGAGG AGTGTGGGCT GCTGCTCTCC 
TCTGAGGGCG AGTGTCAGGG CTGCTACCCG CTGGATGGGC ACATCTTGTG CAAGGCCTGC 
AGCGCCTGGC GCATCCAGGA GCTCTCAGCC ACCGTCACCA CTGACTGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003293.2
CDS	112..1542
Translation	MSGPTWLPPKQPEPARAPQGRAIPRGTPGPPPAHGAALQPHPRVNFCPLPSEQCYQAPGGPEDRGPAWVGSHGVLQHTQGLPADRGGLRPGSLDAEIDLLSSTLAELNGGRGHASRRPDRQAYEPPPPPAYRTGSLKPNPASPLPASPYGGPTPASYTTASTPAGPAFPVQVKVAQPVRGCGPPRRGASQASGPLPGPHFPLPGRGEVWGPGYRSQREPGPGAKEEAAGVSGPAGRGRGGEHGPQVPLSQPPEDELDRLTKKLVHDMNHPPSGEYFGQCGGCGEDVVGDGAGVVALDRVFHVGCFVCSTCRAQLRGQHFYAVERRAYCEGCYVATLEKCATCSQPILDRILRAMGKAYHPGCFTCVVCHRGLDGIPFTVDATSQIHCIEDFHRKFAPRCSVCGGAIMPEPGQEETVRIVALDRSFHIGCYKCEECGLLLSSEGECQGCYPLDGHILCKACSAWRIQELSATVTTDC

Target ORF information:

RefSeq Version	NM_003302.3
Organism	Homo sapiens(human)
Definition	Homo sapiens thyroid hormone receptor interactor 6 (TRIP6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003302.3

ORF Insert Sequence:

ATGTCGGGGC CCACCTGGCT GCCCCCGAAG CAGCCGGAGC CCGCCAGAGC CCCTCAGGGG 
AGGGCGATCC CCCGCGGCAC CCCGGGGCCA CCACCGGCCC ACGGAGCAGC ACTCCAGCCC 
CACCCCAGGG TCAATTTTTG CCCCCTTCCA TCTGAGCAGT GTTACCAGGC CCCAGGGGGA 
CCGGAGGATC GGGGGCCGGC GTGGGTGGGG TCCCATGGAG TACTCCAGCA CACGCAGGGG 
CTCCCTGCAG ACAGGGGGGG CCTTCGCCCT GGAAGCCTGG ACGCCGAGAT AGACTTGCTG 
AGCAGCACGC TGGCCGAGCT GAATGGGGGT CGGGGTCATG CGTCACGGCG ACCAGACCGA 
CAGGCATATG AGCCCCCGCC ACCTCCTGCC TACCGCACGG GCTCCCTGAA GCCAAATCCA 
GCCTCGCCGC TCCCAGCGTC TCCCTATGGG GGCCCCACTC CAGCCTCTTA CACTACCGCC 
AGCACCCCGG CTGGCCCAGC CTTCCCCGTG CAAGTGAAGG TGGCACAGCC AGTGAGGGGC 
TGCGGCCCAC CCAGGCGGGG AGCCTCTCAG GCCTCTGGGC CCCTCCCGGG CCCCCACTTT 
CCTCTCCCAG GCCGAGGTGA AGTCTGGGGG CCTGGCTATA GGAGCCAGAG AGAGCCAGGG 
CCAGGGGCCA AAGAGGAAGC TGCTGGGGTC TCTGGCCCTG CAGGAAGAGG AAGAGGAGGC 
GAGCACGGGC CCCAGGTGCC CCTGAGCCAG CCTCCAGAGG ATGAGCTGGA TAGGCTGACG 
AAGAAGCTGG TTCACGACAT GAACCACCCG CCCAGCGGGG AGTACTTTGG CCAGTGTGGT 
GGCTGCGGAG AAGATGTGGT TGGGGATGGG GCTGGGGTTG TGGCCCTTGA TCGCGTCTTT 
CACGTGGGCT GCTTTGTATG TTCTACATGC CGGGCCCAGC TTCGCGGCCA GCATTTCTAC 
GCCGTGGAGA GGAGGGCATA TTGCGAGGGC TGCTACGTGG CCACCCTGGA GAAATGTGCC 
ACGTGCTCCC AGCCCATCCT GGACCGGATC CTGCGGGCTA TGGGGAAGGC CTACCACCCT 
GGCTGCTTCA CCTGCGTGGT GTGTCACCGC GGCCTCGACG GCATCCCCTT CACAGTGGAT 
GCTACGAGCC AGATCCACTG CATTGAGGAC TTTCACAGGA AGTTTGCCCC AAGATGCTCA 
GTGTGCGGTG GGGCCATAAT GCCTGAGCCA GGTCAGGAGG AGACTGTGAG AATTGTTGCT 
CTGGATCGAA GTTTTCACAT TGGCTGTTAC AAGTGCGAGG AGTGTGGGCT GCTGCTCTCC 
TCTGAGGGCG AGTGTCAGGG CTGCTACCCG CTGGATGGGC ACATCTTGTG CAAGGCCTGC 
AGCGCCTGGC GCATCCAGGA GCTCTCAGCC ACCGTCACCA CTGACTGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TRIP6 ( XM_011516545.1 ) cDNA ORF clone, Homo sapiens(Human) -> XP_011514847.1 Homo sapiens thyroid hormone receptor interactor 6 (TRIP6), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu13308
Clone ID Related Accession (Same CDS sequence)	NM_003302.2 , NM_003302.3 , XM_011516545.1
Accession Version	XM_011516545.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1431bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	thyroid receptor-interacting protein 6 isoform X1
Comment

ATGTCGGGGC CCACCTGGCT GCCCCCGAAG CAGCCGGAGC CCGCCAGAGC CCCTCAGGGG 
AGGGCGATCC CCCGCGGCAC CCCGGGGCCA CCACCGGCCC ACGGAGCAGC ACTCCAGCCC 
CACCCCAGGG TCAATTTTTG CCCCCTTCCA TCTGAGCAGT GTTACCAGGC CCCAGGGGGA 
CCGGAGGATC GGGGGCCGGC GTGGGTGGGG TCCCATGGAG TACTCCAGCA CACGCAGGGG 
CTCCCTGCAG ACAGGGGGGG CCTTCGCCCT GGAAGCCTGG ACGCCGAGAT AGACTTGCTG 
AGCAGCACGC TGGCCGAGCT GAATGGGGGT CGGGGTCATG CGTCACGGCG ACCAGACCGA 
CAGGCATATG AGCCCCCGCC ACCTCCTGCC TACCGCACGG GCTCCCTGAA GCCAAATCCA 
GCCTCGCCGC TCCCAGCGTC TCCCTATGGG GGCCCCACTC CAGCCTCTTA CACTACCGCC 
AGCACCCCGG CTGGCCCAGC CTTCCCCGTG CAAGTGAAGG TGGCACAGCC AGTGAGGGGC 
TGCGGCCCAC CCAGGCGGGG AGCCTCTCAG GCCTCTGGGC CCCTCCCGGG CCCCCACTTT 
CCTCTCCCAG GCCGAGGTGA AGTCTGGGGG CCTGGCTATA GGAGCCAGAG AGAGCCAGGG 
CCAGGGGCCA AAGAGGAAGC TGCTGGGGTC TCTGGCCCTG CAGGAAGAGG AAGAGGAGGC 
GAGCACGGGC CCCAGGTGCC CCTGAGCCAG CCTCCAGAGG ATGAGCTGGA TAGGCTGACG 
AAGAAGCTGG TTCACGACAT GAACCACCCG CCCAGCGGGG AGTACTTTGG CCAGTGTGGT 
GGCTGCGGAG AAGATGTGGT TGGGGATGGG GCTGGGGTTG TGGCCCTTGA TCGCGTCTTT 
CACGTGGGCT GCTTTGTATG TTCTACATGC CGGGCCCAGC TTCGCGGCCA GCATTTCTAC 
GCCGTGGAGA GGAGGGCATA TTGCGAGGGC TGCTACGTGG CCACCCTGGA GAAATGTGCC 
ACGTGCTCCC AGCCCATCCT GGACCGGATC CTGCGGGCTA TGGGGAAGGC CTACCACCCT 
GGCTGCTTCA CCTGCGTGGT GTGTCACCGC GGCCTCGACG GCATCCCCTT CACAGTGGAT 
GCTACGAGCC AGATCCACTG CATTGAGGAC TTTCACAGGA AGTTTGCCCC AAGATGCTCA 
GTGTGCGGTG GGGCCATAAT GCCTGAGCCA GGTCAGGAGG AGACTGTGAG AATTGTTGCT 
CTGGATCGAA GTTTTCACAT TGGCTGTTAC AAGTGCGAGG AGTGTGGGCT GCTGCTCTCC 
TCTGAGGGCG AGTGTCAGGG CTGCTACCCG CTGGATGGGC ACATCTTGTG CAAGGCCTGC 
AGCGCCTGGC GCATCCAGGA GCTCTCAGCC ACCGTCACCA CTGACTGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

XP_011514847.1

Translation

MSGPTWLPPKQPEPARAPQGRAIPRGTPGPPPAHGAALQPHPRVNFCPLPSEQCYQAPGGPEDRGPAWVGSHGVLQHTQGLPADRGGLRPGSLDAEIDLLSSTLAELNGGRGHASRRPDRQAYEPPPPPAYRTGSLKPNPASPLPASPYGGPTPASYTTASTPAGPAFPVQVKVAQPVRGCGPPRRGASQASGPLPGPHFPLPGRGEVWGPGYRSQREPGPGAKEEAAGVSGPAGRGRGGEHGPQVPLSQPPEDELDRLTKKLVHDMNHPPSGEYFGQCGGCGEDVVGDGAGVVALDRVFHVGCFVCSTCRAQLRGQHFYAVERRAYCEGCYVATLEKCATCSQPILDRILRAMGKAYHPGCFTCVVCHRGLDGIPFTVDATSQIHCIEDFHRKFAPRCSVCGGAIMPEPGQEETVRIVALDRSFHIGCYKCEECGLLLSSEGECQGCYPLDGHILCKACSAWRIQELSATVTTDC

Target ORF information:

RefSeq Version	XM_011516545.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens thyroid hormone receptor interactor 6 (TRIP6), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011516545.1

ORF Insert Sequence:

ATGTCGGGGC CCACCTGGCT GCCCCCGAAG CAGCCGGAGC CCGCCAGAGC CCCTCAGGGG 
AGGGCGATCC CCCGCGGCAC CCCGGGGCCA CCACCGGCCC ACGGAGCAGC ACTCCAGCCC 
CACCCCAGGG TCAATTTTTG CCCCCTTCCA TCTGAGCAGT GTTACCAGGC CCCAGGGGGA 
CCGGAGGATC GGGGGCCGGC GTGGGTGGGG TCCCATGGAG TACTCCAGCA CACGCAGGGG 
CTCCCTGCAG ACAGGGGGGG CCTTCGCCCT GGAAGCCTGG ACGCCGAGAT AGACTTGCTG 
AGCAGCACGC TGGCCGAGCT GAATGGGGGT CGGGGTCATG CGTCACGGCG ACCAGACCGA 
CAGGCATATG AGCCCCCGCC ACCTCCTGCC TACCGCACGG GCTCCCTGAA GCCAAATCCA 
GCCTCGCCGC TCCCAGCGTC TCCCTATGGG GGCCCCACTC CAGCCTCTTA CACTACCGCC 
AGCACCCCGG CTGGCCCAGC CTTCCCCGTG CAAGTGAAGG TGGCACAGCC AGTGAGGGGC 
TGCGGCCCAC CCAGGCGGGG AGCCTCTCAG GCCTCTGGGC CCCTCCCGGG CCCCCACTTT 
CCTCTCCCAG GCCGAGGTGA AGTCTGGGGG CCTGGCTATA GGAGCCAGAG AGAGCCAGGG 
CCAGGGGCCA AAGAGGAAGC TGCTGGGGTC TCTGGCCCTG CAGGAAGAGG AAGAGGAGGC 
GAGCACGGGC CCCAGGTGCC CCTGAGCCAG CCTCCAGAGG ATGAGCTGGA TAGGCTGACG 
AAGAAGCTGG TTCACGACAT GAACCACCCG CCCAGCGGGG AGTACTTTGG CCAGTGTGGT 
GGCTGCGGAG AAGATGTGGT TGGGGATGGG GCTGGGGTTG TGGCCCTTGA TCGCGTCTTT 
CACGTGGGCT GCTTTGTATG TTCTACATGC CGGGCCCAGC TTCGCGGCCA GCATTTCTAC 
GCCGTGGAGA GGAGGGCATA TTGCGAGGGC TGCTACGTGG CCACCCTGGA GAAATGTGCC 
ACGTGCTCCC AGCCCATCCT GGACCGGATC CTGCGGGCTA TGGGGAAGGC CTACCACCCT 
GGCTGCTTCA CCTGCGTGGT GTGTCACCGC GGCCTCGACG GCATCCCCTT CACAGTGGAT 
GCTACGAGCC AGATCCACTG CATTGAGGAC TTTCACAGGA AGTTTGCCCC AAGATGCTCA 
GTGTGCGGTG GGGCCATAAT GCCTGAGCCA GGTCAGGAGG AGACTGTGAG AATTGTTGCT 
CTGGATCGAA GTTTTCACAT TGGCTGTTAC AAGTGCGAGG AGTGTGGGCT GCTGCTCTCC 
TCTGAGGGCG AGTGTCAGGG CTGCTACCCG CTGGATGGGC ACATCTTGTG CAAGGCCTGC 
AGCGCCTGGC GCATCCAGGA GCTCTCAGCC ACCGTCACCA CTGACTGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

TRIP6 inhibits Hippo signaling in response to tension at adherens junctions.
EMBO reports(2017 Dec)
Dutta S,Mana-Capelli S,Paramasivam M,Dasgupta I,Cirka H,Billiar K,McCollum D

TRIP6 promotes cell proliferation in hepatocellular carcinoma via suppression of FOXO3a.
Biochemical and biophysical research communications494(3-4)594-601(2017 12)
Zhao W,Dai Y,Dai T,Xie T,Su X,Li J,Zhou X,Meng K,Zhao X

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

An inter-species protein-protein interaction network across vast evolutionary distance.
Molecular systems biology12(4)865(2016 Apr)
Zhong Q,Pevzner SJ,Hao T,Wang Y,Mosca R,Menche J,Taipale M,Ta?an M,Fan C,Yang X,Haley P,Murray RR,Mer F,Gebreab F,Tam S,MacWilliams A,Dricot A,Reichert P,Santhanam B,Ghamsari L,Calderwood MA,Rolland T,Charloteaux B,Lindquist S,Barab?si AL,Hill DE,Aloy P,Cusick ME,Xia Y,Roth FP,Vidal M

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Cell164(4)805-17(2016 Feb)
Yang X,Coulombe-Huntington J,Kang S,Sheynkman GM,Hao T,Richardson A,Sun S,Yang F,Shen YA,Murray RR,Spirohn K,Begg BE,Duran-Frigola M,MacWilliams A,Pevzner SJ,Zhong Q,Trigg SA,Tam S,Ghamsari L,Sahni N,Yi S,Rodriguez MD,Balcha D,Tan G,Costanzo M,Andrews B,Boone C,Zhou XJ,Salehi-Ashtiani K,Charloteaux B,Chen AA,Calderwood MA,Aloy P,Roth FP,Hill DE,Iakoucheva LM,Xia Y,Vidal M

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TRIP6 cDNA ORF clone, Homo sapiens(Human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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