TPH1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TPH1
Entrez Gene ID	7166
Full Name	tryptophan hydroxylase 1
Synonyms	TPRH,TRPH
General protein information	Preferred Names tryptophan hydroxylase 1 Names tryptophan 5-hydroxylase 1 L-tryptophan hydroxylase indoleacetic acid-5-hydroxylase tryptophan 5-monooxygenase 1 tryptophan hydroxylase (tryptophan 5-monooxygenase)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11p15.1
Summary	This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.[provided by RefSeq, Apr 2009].
Disorder MIM:	191060

mRNA and Protein(s)

mRNA	Protein	Name
NM_004179.2	NP_004170.1	tryptophan 5-hydroxylase 1
NM_004179.3	NP_004170.1	tryptophan 5-hydroxylase 1

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	TPH1	NP_990287.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006020	XP_316057.3
	TPH1	XP_001083991.2
Canis lupus familiaris (dog)	TPH1	NP_001184120.1
Rattus norvegicus (Norway rat)	Tph1	NP_001094104.1
Xenopus tropicalis (tropical clawed frog)	LOC100497239	XP_002942733.1
Danio rerio (zebrafish)	tph1b	NP_001001843.2
Danio rerio (zebrafish)	tph1a	NP_840091.1
Homo sapiens (human)	TPH1	NP_004170.1
Pan troglodytes (chimpanzee)	TPH1	XP_521852.3
Bos taurus (cattle)	TPH1	XP_005216133.1
Mus musculus (house mouse)	Tph1	NP_033440.1
Drosophila melanogaster (fruit fly)	Trh	NP_612080.1

Gene Ontology
Bibliography

Related articles in PubMed

Association between single nucleotide polymorphisms of TPH1 and TPH2 genes, and depressive disorders.
Wigner P, Czarny P, Synowiec E, Bijak M, Bia?ek K, Talarowska M, Galecki P, Szemraj J, Sliwinski T
Journal of cellular and molecular medicine(2018 Jan)

Isoform-Specific Substrate Inhibition Mechanism of Human Tryptophan Hydroxylase.
Tidemand KD, Peters GH, Harris P, Stensgaard E, Christensen HEM
Biochemistry56(46)6155-6164(2017 Nov)

Genetic moderation of cocaine subjective effects by variation in the TPH1, TPH2, and SLC6A4 serotonin genes.
Patriquin MA, Hamon SC, Harding MJ, Nielsen EM, Newton TF, De La Garza R 2nd, Nielsen DA
Psychiatric genetics27(5)178-186(2017 Oct)

Human placenta expresses both peripheral and neuronal isoform of tryptophan hydroxylase.
Laurent L, Deroy K, St-Pierre J, C?t? F, Sanderson JT, Vaillancourt C
Biochimie140159-165(2017 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study demonstrates that both TPH1 and TPH2 are expressed in human and mouse placenta throughout pregnancy and helps to better understand the placental serotonin system, which is crucial for healthy pregnancy and fetal development.
Title: Human placenta expresses both peripheral and neuronal isoform of tryptophan hydroxylase.

Associations between serotonin transporter gene and tryptophan hydroxylase 1 polymorphisms and several Temperament and Character Inventory dimensions and subdimensions were revealed in subjects with bipolar disorder.
Title: Personality traits as an endophenotype in genetic studies on suicidality in bipolar disorder.

results confirm the role of TPH1, TPH2, 5HT2A, CRHR1 and ACP1 variants in the risk of suicidal behavior.
Title: Suicide behavior as a quantitative trait and its genetic background.

Genetic association studies have revealed contradictory results about the effect of the TPH1 A218C (rs1800532) polymorphism on suicidal behavior in different populations. Investigated A218C polymorphism in 109 suicide attempters and 98 healthy controls. Our results provide evidence that A allele of TPH1 A218C polymorphism may be associated with suicidal behavior in Turkish population
Title: TPH1 A218 allele is associated with suicidal behavior in Turkish population.

These results suggested that silencing of androgen/androgen receptor signaling may cause initiation and progression of seminomas through increase in TPH1 gene expression level.
Title: Androgen suppresses testicular cancer cell growth in vitro and in vivo.

The following TPH1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TPH1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22236	NM_004179.3 Latest version!	Homo sapiens tryptophan hydroxylase 1 (TPH1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu22236	NM_004179.2	Homo sapiens tryptophan hydroxylase 1 (TPH1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TPH1 ( NM_004179.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_004170.1 Homo sapiens tryptophan hydroxylase 1 (TPH1), mRNA.

Price & Availability↑

CloneID	OHu22236
Clone ID Related Accession (Same CDS sequence)	NM_004179.2 , NM_004179.3
Accession Version	NM_004179.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1335bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	tryptophan 5-hydroxylase 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP423529.1, BC106739.1, BM451912.1 and AC055860.13. This sequence is a reference standard in the RefSeqGene project. On Apr 3, 2009 this sequence version replaced NM_004179.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC106739.1, X52836.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGATTGAAG ACAATAAGGA GAACAAAGAC CATTCCTTAG AAAGGGGAAG AGCAAGTCTC 
ATTTTTTCCT TAAAGAATGA AGTTGGAGGA CTTATAAAAG CCCTGAAAAT CTTTCAGGAG 
AAGCATGTGA ATCTGTTACA TATCGAGTCC CGAAAATCAA AAAGAAGAAA CTCAGAATTT 
GAGATTTTTG TTGACTGTGA CATCAACAGA GAACAATTGA ATGATATTTT TCATCTGCTG 
AAGTCTCATA CCAATGTTCT CTCTGTGAAT CTACCAGATA ATTTTACTTT GAAGGAAGAT 
GGTATGGAAA CTGTTCCTTG GTTTCCAAAG AAGATTTCTG ACCTGGACCA TTGTGCCAAC 
AGAGTTCTGA TGTATGGATC TGAACTAGAT GCAGACCATC CTGGCTTCAA AGACAATGTC 
TACCGTAAAC GTCGAAAGTA TTTTGCGGAC TTGGCTATGA ACTATAAACA TGGAGACCCC 
ATTCCAAAGG TTGAATTCAC TGAAGAGGAG ATTAAGACCT GGGGAACCGT ATTCCAAGAG 
CTCAACAAAC TCTACCCAAC CCATGCTTGC AGAGAGTATC TCAAAAACTT ACCTTTGCTT 
TCTAAATATT GTGGATATCG GGAGGATAAT ATCCCACAAT TGGAAGATGT CTCCAACTTT 
TTAAAAGAGC GTACAGGTTT TTCCATCCGT CCTGTGGCTG GTTACTTATC ACCAAGAGAT 
TTCTTATCAG GTTTAGCCTT TCGAGTTTTT CACTGCACTC AATATGTGAG ACACAGTTCA 
GATCCCTTCT ATACCCCAGA GCCAGATACC TGCCATGAAC TCTTAGGTCA TGTCCCGCTT 
TTGGCTGAAC CTAGTTTTGC CCAATTCTCC CAAGAAATTG GCTTGGCTTC TCTTGGCGCT 
TCAGAGGAGG CTGTTCAAAA ACTGGCAACG TGCTACTTTT TCACTGTGGA GTTTGGTCTA 
TGTAAACAAG ATGGACAGCT AAGAGTCTTT GGTGCTGGCT TACTTTCTTC TATCAGTGAA 
CTCAAACATG CACTTTCTGG ACATGCCAAA GTAAAGCCCT TTGATCCCAA GATTACCTGC 
AAACAGGAAT GTCTTATCAC AACTTTTCAA GATGTCTACT TTGTATCTGA AAGTTTTGAA 
GATGCAAAGG AGAAGATGAG AGAATTTACC AAAACAATTA AGCGTCCATT TGGAGTGAAG 
TATAATCCAT ATACACGGAG TATTCAGATC CTGAAAGACA CCAAGAGCAT AACCAGTGCC 
ATGAATGAGC TGCAGCATGA TCTCGATGTT GTCAGTGATG CCCTTGCTAA GGTCAGCAGG 
AAGCCGAGTA TCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004170.1
CDS	27..1361
Translation	MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKVSRKPSI

Target ORF information:

RefSeq Version	NM_004179.2
Organism	Homo sapiens(human)
Definition	Homo sapiens tryptophan hydroxylase 1 (TPH1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004179.2

ORF Insert Sequence:

ATGATTGAAG ACAATAAGGA GAACAAAGAC CATTCCTTAG AAAGGGGAAG AGCAAGTCTC 
ATTTTTTCCT TAAAGAATGA AGTTGGAGGA CTTATAAAAG CCCTGAAAAT CTTTCAGGAG 
AAGCATGTGA ATCTGTTACA TATCGAGTCC CGAAAATCAA AAAGAAGAAA CTCAGAATTT 
GAGATTTTTG TTGACTGTGA CATCAACAGA GAACAATTGA ATGATATTTT TCATCTGCTG 
AAGTCTCATA CCAATGTTCT CTCTGTGAAT CTACCAGATA ATTTTACTTT GAAGGAAGAT 
GGTATGGAAA CTGTTCCTTG GTTTCCAAAG AAGATTTCTG ACCTGGACCA TTGTGCCAAC 
AGAGTTCTGA TGTATGGATC TGAACTAGAT GCAGACCATC CTGGCTTCAA AGACAATGTC 
TACCGTAAAC GTCGAAAGTA TTTTGCGGAC TTGGCTATGA ACTATAAACA TGGAGACCCC 
ATTCCAAAGG TTGAATTCAC TGAAGAGGAG ATTAAGACCT GGGGAACCGT ATTCCAAGAG 
CTCAACAAAC TCTACCCAAC CCATGCTTGC AGAGAGTATC TCAAAAACTT ACCTTTGCTT 
TCTAAATATT GTGGATATCG GGAGGATAAT ATCCCACAAT TGGAAGATGT CTCCAACTTT 
TTAAAAGAGC GTACAGGTTT TTCCATCCGT CCTGTGGCTG GTTACTTATC ACCAAGAGAT 
TTCTTATCAG GTTTAGCCTT TCGAGTTTTT CACTGCACTC AATATGTGAG ACACAGTTCA 
GATCCCTTCT ATACCCCAGA GCCAGATACC TGCCATGAAC TCTTAGGTCA TGTCCCGCTT 
TTGGCTGAAC CTAGTTTTGC CCAATTCTCC CAAGAAATTG GCTTGGCTTC TCTTGGCGCT 
TCAGAGGAGG CTGTTCAAAA ACTGGCAACG TGCTACTTTT TCACTGTGGA GTTTGGTCTA 
TGTAAACAAG ATGGACAGCT AAGAGTCTTT GGTGCTGGCT TACTTTCTTC TATCAGTGAA 
CTCAAACATG CACTTTCTGG ACATGCCAAA GTAAAGCCCT TTGATCCCAA GATTACCTGC 
AAACAGGAAT GTCTTATCAC AACTTTTCAA GATGTCTACT TTGTATCTGA AAGTTTTGAA 
GATGCAAAGG AGAAGATGAG AGAATTTACC AAAACAATTA AGCGTCCATT TGGAGTGAAG 
TATAATCCAT ATACACGGAG TATTCAGATC CTGAAAGACA CCAAGAGCAT AACCAGTGCC 
ATGAATGAGC TGCAGCATGA TCTCGATGTT GTCAGTGATG CCCTTGCTAA GGTCAGCAGG 
AAGCCGAGTA TCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TPH1 ( NM_004179.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004170.1 Homo sapiens tryptophan hydroxylase 1 (TPH1), mRNA.

Price & Availability↑

CloneID	OHu22236
Clone ID Related Accession (Same CDS sequence)	NM_004179.2 , NM_004179.3
Accession Version	NM_004179.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1335bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-27
Organism	Homo sapiens(human)
Product	tryptophan 5-hydroxylase 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC055860.13 and KF455332.1. This sequence is a reference standard in the RefSeqGene project. On Aug 5, 2019 this sequence version replaced NM_004179.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.130127.1, SRR1803617.132818.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGATTGAAG ACAATAAGGA GAACAAAGAC CATTCCTTAG AAAGGGGAAG AGCAAGTCTC 
ATTTTTTCCT TAAAGAATGA AGTTGGAGGA CTTATAAAAG CCCTGAAAAT CTTTCAGGAG 
AAGCATGTGA ATCTGTTACA TATCGAGTCC CGAAAATCAA AAAGAAGAAA CTCAGAATTT 
GAGATTTTTG TTGACTGTGA CATCAACAGA GAACAATTGA ATGATATTTT TCATCTGCTG 
AAGTCTCATA CCAATGTTCT CTCTGTGAAT CTACCAGATA ATTTTACTTT GAAGGAAGAT 
GGTATGGAAA CTGTTCCTTG GTTTCCAAAG AAGATTTCTG ACCTGGACCA TTGTGCCAAC 
AGAGTTCTGA TGTATGGATC TGAACTAGAT GCAGACCATC CTGGCTTCAA AGACAATGTC 
TACCGTAAAC GTCGAAAGTA TTTTGCGGAC TTGGCTATGA ACTATAAACA TGGAGACCCC 
ATTCCAAAGG TTGAATTCAC TGAAGAGGAG ATTAAGACCT GGGGAACCGT ATTCCAAGAG 
CTCAACAAAC TCTACCCAAC CCATGCTTGC AGAGAGTATC TCAAAAACTT ACCTTTGCTT 
TCTAAATATT GTGGATATCG GGAGGATAAT ATCCCACAAT TGGAAGATGT CTCCAACTTT 
TTAAAAGAGC GTACAGGTTT TTCCATCCGT CCTGTGGCTG GTTACTTATC ACCAAGAGAT 
TTCTTATCAG GTTTAGCCTT TCGAGTTTTT CACTGCACTC AATATGTGAG ACACAGTTCA 
GATCCCTTCT ATACCCCAGA GCCAGATACC TGCCATGAAC TCTTAGGTCA TGTCCCGCTT 
TTGGCTGAAC CTAGTTTTGC CCAATTCTCC CAAGAAATTG GCTTGGCTTC TCTTGGCGCT 
TCAGAGGAGG CTGTTCAAAA ACTGGCAACG TGCTACTTTT TCACTGTGGA GTTTGGTCTA 
TGTAAACAAG ATGGACAGCT AAGAGTCTTT GGTGCTGGCT TACTTTCTTC TATCAGTGAA 
CTCAAACATG CACTTTCTGG ACATGCCAAA GTAAAGCCCT TTGATCCCAA GATTACCTGC 
AAACAGGAAT GTCTTATCAC AACTTTTCAA GATGTCTACT TTGTATCTGA AAGTTTTGAA 
GATGCAAAGG AGAAGATGAG AGAATTTACC AAAACAATTA AGCGTCCATT TGGAGTGAAG 
TATAATCCAT ATACACGGAG TATTCAGATC CTGAAAGACA CCAAGAGCAT AACCAGTGCC 
ATGAATGAGC TGCAGCATGA TCTCGATGTT GTCAGTGATG CCCTTGCTAA GGTCAGCAGG 
AAGCCGAGTA TCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004170.1
CDS	56..1390
Translation	MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKVSRKPSI

Target ORF information:

RefSeq Version	NM_004179.3
Organism	Homo sapiens(human)
Definition	Homo sapiens tryptophan hydroxylase 1 (TPH1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004179.3

ORF Insert Sequence:

ATGATTGAAG ACAATAAGGA GAACAAAGAC CATTCCTTAG AAAGGGGAAG AGCAAGTCTC 
ATTTTTTCCT TAAAGAATGA AGTTGGAGGA CTTATAAAAG CCCTGAAAAT CTTTCAGGAG 
AAGCATGTGA ATCTGTTACA TATCGAGTCC CGAAAATCAA AAAGAAGAAA CTCAGAATTT 
GAGATTTTTG TTGACTGTGA CATCAACAGA GAACAATTGA ATGATATTTT TCATCTGCTG 
AAGTCTCATA CCAATGTTCT CTCTGTGAAT CTACCAGATA ATTTTACTTT GAAGGAAGAT 
GGTATGGAAA CTGTTCCTTG GTTTCCAAAG AAGATTTCTG ACCTGGACCA TTGTGCCAAC 
AGAGTTCTGA TGTATGGATC TGAACTAGAT GCAGACCATC CTGGCTTCAA AGACAATGTC 
TACCGTAAAC GTCGAAAGTA TTTTGCGGAC TTGGCTATGA ACTATAAACA TGGAGACCCC 
ATTCCAAAGG TTGAATTCAC TGAAGAGGAG ATTAAGACCT GGGGAACCGT ATTCCAAGAG 
CTCAACAAAC TCTACCCAAC CCATGCTTGC AGAGAGTATC TCAAAAACTT ACCTTTGCTT 
TCTAAATATT GTGGATATCG GGAGGATAAT ATCCCACAAT TGGAAGATGT CTCCAACTTT 
TTAAAAGAGC GTACAGGTTT TTCCATCCGT CCTGTGGCTG GTTACTTATC ACCAAGAGAT 
TTCTTATCAG GTTTAGCCTT TCGAGTTTTT CACTGCACTC AATATGTGAG ACACAGTTCA 
GATCCCTTCT ATACCCCAGA GCCAGATACC TGCCATGAAC TCTTAGGTCA TGTCCCGCTT 
TTGGCTGAAC CTAGTTTTGC CCAATTCTCC CAAGAAATTG GCTTGGCTTC TCTTGGCGCT 
TCAGAGGAGG CTGTTCAAAA ACTGGCAACG TGCTACTTTT TCACTGTGGA GTTTGGTCTA 
TGTAAACAAG ATGGACAGCT AAGAGTCTTT GGTGCTGGCT TACTTTCTTC TATCAGTGAA 
CTCAAACATG CACTTTCTGG ACATGCCAAA GTAAAGCCCT TTGATCCCAA GATTACCTGC 
AAACAGGAAT GTCTTATCAC AACTTTTCAA GATGTCTACT TTGTATCTGA AAGTTTTGAA 
GATGCAAAGG AGAAGATGAG AGAATTTACC AAAACAATTA AGCGTCCATT TGGAGTGAAG 
TATAATCCAT ATACACGGAG TATTCAGATC CTGAAAGACA CCAAGAGCAT AACCAGTGCC 
ATGAATGAGC TGCAGCATGA TCTCGATGTT GTCAGTGATG CCCTTGCTAA GGTCAGCAGG 
AAGCCGAGTA TCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Association between single nucleotide polymorphisms of TPH1 and TPH2 genes, and depressive disorders.
Journal of cellular and molecular medicine(2018 Jan)
Wigner P,Czarny P,Synowiec E,Bijak M,Bia?ek K,Talarowska M,Galecki P,Szemraj J,Sliwinski T

Isoform-Specific Substrate Inhibition Mechanism of Human Tryptophan Hydroxylase.
Biochemistry56(46)6155-6164(2017 Nov)
Tidemand KD,Peters GH,Harris P,Stensgaard E,Christensen HEM

Genetic moderation of cocaine subjective effects by variation in the TPH1, TPH2, and SLC6A4 serotonin genes.
Psychiatric genetics27(5)178-186(2017 Oct)
Patriquin MA,Hamon SC,Harding MJ,Nielsen EM,Newton TF,De La Garza R 2nd,Nielsen DA

Human placenta expresses both peripheral and neuronal isoform of tryptophan hydroxylase.
Biochimie140159-165(2017 Sep)
Laurent L,Deroy K,St-Pierre J,C?t? F,Sanderson JT,Vaillancourt C

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TPH1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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