C1R cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	C1R
Entrez Gene ID	715
Full Name	complement C1r
Synonyms	EDSPD1
General protein information	Preferred Names complement C1r Names complement C1r subcomponent complement component 1, r subcomponent
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12p13.31
Disorder MIM:	613785
Disorder Html:	Ehlers-Danlos syndrome, periodontal type, 1, 130080 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001354346.2	NP_001341275.1	complement C1r subcomponent isoform 2 preproprotein
NM_001733.4	NP_001724.3	complement C1r subcomponent precursor
XM_017019915.1	XP_016875404.1	complement C1r subcomponent isoform X1
NM_001354346.1	NP_001341275.1	complement C1r subcomponent isoform 2 preproprotein
NM_001733.5	NP_001724.4	complement C1r subcomponent isoform 1 preproprotein
NM_001733.7	NP_001724.4	complement C1r subcomponent isoform 1 preproprotein

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	C1R	XP_416518.2
Pan troglodytes (chimpanzee)	C1R	NP_001029292.1
Canis lupus familiaris (dog)	C1R	XP_005637266.1
Mus musculus (house mouse)	C1ra	NP_075632.3
Xenopus tropicalis (tropical clawed frog)	LOC100498646	XP_002941255.1
Homo sapiens (human)	C1R	NP_001724.3
Mus musculus (house mouse)	C1rb	NP_001106827.1
Rattus norvegicus (Norway rat)	C1r	NP_001128027.1
Xenopus tropicalis (tropical clawed frog)	LOC100485749	XP_002941260.2

Gene Ontology
Bibliography

Related articles in PubMed

Brief Report: Deficiency of Complement 1r Subcomponent in Early-Onset Systemic Lupus Erythematosus: The Role of Disease-Modifying Alleles in a Monogenic Disease.
Demirkaya E, Zhou Q, Smith CK, Ombrello MJ, Deuitch N, Tsai WL, Hoffmann P, Remmers EF, Takeuchi M, Park YH, Chae J, Barut K, Simsek D, Adrovic A, Sahin S, Caliskan S, Chandrasekharappa SC, Hasni SA, Ombrello AK, Gadina M, Kastner DL, Kaplan MJ, Kasapcopur O, Aksentijevich I
Arthritis & rheumatology (Hoboken, N.J.)69(9)1832-1839(2017 09)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Structure and activation of C1, the complex initiating the classical pathway of the complement cascade.
Mortensen SA, Sander B, Jensen RK, Pedersen JS, Golas MM, Jensenius JC, Hansen AG, Thiel S, Andersen GR
Proceedings of the National Academy of Sciences of the United States of America114(5)986-991(2017 Jan)

Periodontal Ehlers-Danlos Syndrome Is Caused by Mutations in C1R and C1S, which Encode Subcomponents C1r and C1s of Complement.
Kapferer-Seebacher I, Pepin M, Werner R, Aitman TJ, Nordgren A, Stoiber H, Thielens N, Gaboriaud C, Amberger A, Schossig A, Gruber R, Giunta C, Bamshad M, Bj?rck E, Chen C, Chitayat D, Dorschner M, Schmitt-Egenolf M, Hale CJ, Hanna D, Hennies HC, Heiss-Kisielewsky I, Lindstrand A, Lundberg P, Mitchell AL, Nickerson DA, Reinstein E, Rohrbach M, Romani N, Schmuth M, Silver R, Taylan F, Vandersteen A, Vandrovcova J, Weerakkody R, Yang M, Pope FM, , Byers PH, Zschocke J
American journal of human genetics99(5)1005-1014(2016 Nov)

Proteomic analysis for the identification of serum diagnostic markers for joint hypermobility syndrome.
Watanabe A, Satoh K, Maniwa T, Matsumoto K
International journal of molecular medicine37(2)461-7(2016 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We identified a novel, homozygous, loss-of-function mutation (p.Pro445Leufs*11) in the C1R gene. Using the Sanger method of DNA sequencing in 14 family members, we confirmed the presence of the mutation in 4 patients with early-onset systemic lupus erythematosus and in an asymptomatic 9-year-old girl. Complement levels were low in sera from patients with truncated C1r protein.
Title: Brief Report: Deficiency of Complement 1r Subcomponent in Early-Onset Systemic Lupus Erythematosus: The Role of Disease-Modifying Alleles in a Monogenic Disease.

Periodontal Ehlers-Danlos Syndrome in at least the great majority of cases results from specific classes of heterozygous mutations in C1R and C1S.
Title: Periodontal Ehlers-Danlos Syndrome Is Caused by Mutations in C1R and C1S, which Encode Subcomponents C1r and C1s of Complement.

We confirmed increased levels of C1R and VTN in sera from patients with Joint hypermobility syndrome by western blot analyses
Title: Proteomic analysis for the identification of serum diagnostic markers for joint hypermobility syndrome.

C1q exists as the C1 complex (C1qC1r2C1s2), and C1q binding to ligands activates the C1r/C1s proteases. Incubation of nucleoli with C1 caused degradation of the nucleolar proteins nucleolin and nucleophosmin 1. T
Title: C1q protein binds to the apoptotic nucleolus and causes C1 protease degradation of nucleolar proteins.

Analysis of its interaction properties by surface plasmon resonance shows that rC1q retains the ability of serum C1q to associate with the C1s-C1r-C1r-C1s tetramer, to recognize physiological C1q ligands such as IgG and pentraxin 3
Title: Expression of recombinant human complement C1q allows identification of the C1r/C1s-binding sites.

The following C1R gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the C1R cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03683	NM_001733.4 Latest version!	Homo sapiens complement C1r (C1R), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
OHu103328	NM_001733.7 Latest version!	Homo sapiens complement C1r (C1R), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
OHu84130	NM_001354346.2 Latest version!	Homo sapiens complement C1r (C1R), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
OHu84130	XM_017019915.1 Latest version!	Homo sapiens complement C1r subcomponent (C1R), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
View Old Accession Versions >>
OHu84130	NM_001354346.1	Homo sapiens complement C1r (C1R), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
OHu103328	NM_001733.5	Homo sapiens complement C1r (C1R), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

C1R ( NM_001733.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001724.3 Homo sapiens complement C1r (C1R), mRNA.

Price & Availability↑

CloneID	OHu03683
Clone ID Related Accession (Same CDS sequence)	NM_001733.4
Accession Version	NM_001733.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2118bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-04-26
Organism	Homo sapiens(Human)
Product	complement C1r subcomponent precursor
Comment	PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC035220.1. On or before Mar 4, 2006 this sequence version replaced XM_925842.1, XM_930681.1, NM_001733.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC035220.1, SRR1803617.180836.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467144, SAMEA2467148 [ECO:0000348] ##Evidence-Data-END##

ATGTGGCTCT TGTACCTCCT GGTGCCGGCC CTGTTCTGCA GGGCAGGAGG CTCCATTCCC 
ATCCCTCAGA AGTTATTTGG GGAGGTGACT TCCCCTCTGT TCCCCAAGCC TTACCCCAAC 
AACTTTGAAA CAACCACTGT GATCACAGTC CCCACGGGAT ACAGGGTGAA GCTCGTCTTC 
CAGCAGTTTG ACCTGGAGCC TTCTGAAGGC TGCTTCTATG ATTATGTCAA GATCTCTGCT 
GATAAGAAAA GCCTGGGGAG GTTCTGTGGG CAACTGGGTT CTCCACTGGG CAACCCCCCG 
GGAAAGAAGG AATTTATGTC CCAAGGGAAC AAGATGCTGC TGACCTTCCA CACAGACTTC 
TCCAACGAGG AGAATGGGAC CATCATGTTC TACAAGGGCT TCCTGGCCTA CTACCAAGCT 
GTGGACCTTG ATGAATGTGC TTCCCGGAGC AAATTAGGGG AGGAGGATCC CCAGCCCCAG 
TGCCAGCACC TGTGTCACAA CTACGTTGGA GGCTACTTCT GTTCCTGCCG TCCAGGCTAT 
GAGCTTCAGG AAGACAGGCA TTCCTGCCAG GCTGAGTGCA GCAGCGAGCT GTACACGGAG 
GCATCAGGCT ACATCTCCAG CCTGGAGTAC CCTCGGTCCT ACCCCCCTGA CCTGCGCTGC 
AACTACAGCA TCCGGGTGGA GCGGGGCCTC ACCCTGCACC TCAAGTTCCT GGAGCCTTTT 
GATATTGATG ACCACCAGCA AGTACACTGC CCCTATGACC AGCTACAGAT CTATGCCAAC 
GGGAAGAACA TTGGCGAGTT CTGTGGGAAG CAAAGGCCCC CCGACCTCGA CACCAGCAGC 
AATGCTGTGG ATCTGCTGTT CTTCACAGAT GAGTCGGGGG ACAGCCGGGG CTGGAAGCTG 
CGCTACACCA CCGAGATCAT CAAGTGCCCC CAGCCCAAGA CCCTAGACGA GTTCACCATC 
ATCCAGAACC TGCAGCCTCA GTACCAGTTC CGTGACTACT TCATTGCTAC CTGCAAGCAA 
GGCTACCAGC TCATAGAGGG GAACCAGGTG CTGCATTCCT TCACAGCTGT CTGCCAGGAT 
GATGGCACGT GGCATCGTGC CATGCCCAGA TGCAAGATCA AGGACTGTGG GCAGCCCCGA 
AACCTGCCTA ATGGTGACTT CCGTTACACC ACCACAATGG GAGTGAACAC CTACAAGGCC 
CGTATCCAGT ACTACTGCCA TGAGCCATAT TACAAGATGC AGACCAGAGC TGGCAGCAGG 
GAGTCTGAGC AAGGGGTGTA CACCTGCACA GCACAGGGCA TTTGGAAGAA TGAACAGAAG 
GGAGAGAAGA TTCCTCGGTG CTTGCCAGTG TGTGGGAAGC CCGTGAACCC CGTGGAACAG 
AGGCAGCGCA TCATCGGAGG GCAAAAAGCC AAGATGGGCA ACTTCCCCTG GCAGGTGTTC 
ACCAACATCC ACGGGCGCGG GGGCGGGGCC CTGCTGGGCG ACCGCTGGAT CCTCACAGCT 
GCCCACACCC TGTATCCCAA GGAACACGAA GCGCAAAGCA ACGCCTCTTT GGATGTGTTC 
CTGGGCCACA CAAATGTGGA AGAGCTCATG AAGCTAGGAA ATCACCCCAT CCGCAGGGTC 
AGCGTCCACC CGGACTACCG TCAGGATGAG TCCTACAATT TTGAGGGGGA CATCGCCCTG 
CTGGAGCTGG AAAATAGTGT CACCCTGGGT CCCAACCTCC TCCCCATCTG CCTCCCTGAC 
AACGATACCT TCTACGACCT GGGCTTGATG GGCTATGTCA GTGGCTTCGG GGTCATGGAG 
GAGAAGATTG CTCATGACCT CAGGTTTGTC CGTCTGCCCG TAGCTAATCC ACAGGCCTGT 
GAGAACTGGC TCCGGGGAAA GAATAGGATG GATGTGTTCT CTCAAAACAT GTTCTGTGCT 
GGACACCCAT CTCTAAAGCA GGACGCCTGC CAGGGGGATA GTGGGGGCGT TTTTGCAGTA 
AGGGACCCGA ACACTGATCG CTGGGTGGCC ACGGGCATCG TGTCCTGGGG CATCGGGTGC 
AGCAGGGGCT ATGGCTTCTA CACCAAAGTG CTCAACTACG TGGACTGGAT CAAGAAAGAG 
ATGGAGGAGG AGGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001724.3
CDS	60..2177
Translation	MWLLYLLVPALFCRAGGSIPIPQKLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCFYDYVKISADKKSLGRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDFSNEENGTIMFYKGFLAYYQAVDLDECASRSKLGEEDPQPQCQHLCHNYVGGYFCSCRPGYELQEDRHSCQAECSSELYTEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPFDIDDHQQVHCPYDQLQIYANGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLRYTTEIIKCPQPKTLDEFTIIQNLQPQYQFRDYFIATCKQGYQLIEGNQVLHSFTAVCQDDGTWHRAMPRCKIKDCGQPRNLPNGDFRYTTTMGVNTYKARIQYYCHEPYYKMQTRAGSRESEQGVYTCTAQGIWKNEQKGEKIPRCLPVCGKPVNPVEQRQRIIGGQKAKMGNFPWQVFTNIHGRGGGALLGDRWILTAAHTLYPKEHEAQSNASLDVFLGHTNVEELMKLGNHPIRRVSVHPDYRQDESYNFEGDIALLELENSVTLGPNLLPICLPDNDTFYDLGLMGYVSGFGVMEEKIAHDLRFVRLPVANPQACENWLRGKNRMDVFSQNMFCAGHPSLKQDACQGDSGGVFAVRDPNTDRWVATGIVSWGIGCSRGYGFYTKVLNYVDWIKKEMEEED

Target ORF information:

RefSeq Version	NM_001733.4
Organism	Homo sapiens(Human)
Definition	Homo sapiens complement C1r (C1R), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001733.4

ORF Insert Sequence:

ATGTGGCTCT TGTACCTCCT GGTGCCGGCC CTGTTCTGCA GGGCAGGAGG CTCCATTCCC 
ATCCCTCAGA AGTTATTTGG GGAGGTGACT TCCCCTCTGT TCCCCAAGCC TTACCCCAAC 
AACTTTGAAA CAACCACTGT GATCACAGTC CCCACGGGAT ACAGGGTGAA GCTCGTCTTC 
CAGCAGTTTG ACCTGGAGCC TTCTGAAGGC TGCTTCTATG ATTATGTCAA GATCTCTGCT 
GATAAGAAAA GCCTGGGGAG GTTCTGTGGG CAACTGGGTT CTCCACTGGG CAACCCCCCG 
GGAAAGAAGG AATTTATGTC CCAAGGGAAC AAGATGCTGC TGACCTTCCA CACAGACTTC 
TCCAACGAGG AGAATGGGAC CATCATGTTC TACAAGGGCT TCCTGGCCTA CTACCAAGCT 
GTGGACCTTG ATGAATGTGC TTCCCGGAGC AAATTAGGGG AGGAGGATCC CCAGCCCCAG 
TGCCAGCACC TGTGTCACAA CTACGTTGGA GGCTACTTCT GTTCCTGCCG TCCAGGCTAT 
GAGCTTCAGG AAGACAGGCA TTCCTGCCAG GCTGAGTGCA GCAGCGAGCT GTACACGGAG 
GCATCAGGCT ACATCTCCAG CCTGGAGTAC CCTCGGTCCT ACCCCCCTGA CCTGCGCTGC 
AACTACAGCA TCCGGGTGGA GCGGGGCCTC ACCCTGCACC TCAAGTTCCT GGAGCCTTTT 
GATATTGATG ACCACCAGCA AGTACACTGC CCCTATGACC AGCTACAGAT CTATGCCAAC 
GGGAAGAACA TTGGCGAGTT CTGTGGGAAG CAAAGGCCCC CCGACCTCGA CACCAGCAGC 
AATGCTGTGG ATCTGCTGTT CTTCACAGAT GAGTCGGGGG ACAGCCGGGG CTGGAAGCTG 
CGCTACACCA CCGAGATCAT CAAGTGCCCC CAGCCCAAGA CCCTAGACGA GTTCACCATC 
ATCCAGAACC TGCAGCCTCA GTACCAGTTC CGTGACTACT TCATTGCTAC CTGCAAGCAA 
GGCTACCAGC TCATAGAGGG GAACCAGGTG CTGCATTCCT TCACAGCTGT CTGCCAGGAT 
GATGGCACGT GGCATCGTGC CATGCCCAGA TGCAAGATCA AGGACTGTGG GCAGCCCCGA 
AACCTGCCTA ATGGTGACTT CCGTTACACC ACCACAATGG GAGTGAACAC CTACAAGGCC 
CGTATCCAGT ACTACTGCCA TGAGCCATAT TACAAGATGC AGACCAGAGC TGGCAGCAGG 
GAGTCTGAGC AAGGGGTGTA CACCTGCACA GCACAGGGCA TTTGGAAGAA TGAACAGAAG 
GGAGAGAAGA TTCCTCGGTG CTTGCCAGTG TGTGGGAAGC CCGTGAACCC CGTGGAACAG 
AGGCAGCGCA TCATCGGAGG GCAAAAAGCC AAGATGGGCA ACTTCCCCTG GCAGGTGTTC 
ACCAACATCC ACGGGCGCGG GGGCGGGGCC CTGCTGGGCG ACCGCTGGAT CCTCACAGCT 
GCCCACACCC TGTATCCCAA GGAACACGAA GCGCAAAGCA ACGCCTCTTT GGATGTGTTC 
CTGGGCCACA CAAATGTGGA AGAGCTCATG AAGCTAGGAA ATCACCCCAT CCGCAGGGTC 
AGCGTCCACC CGGACTACCG TCAGGATGAG TCCTACAATT TTGAGGGGGA CATCGCCCTG 
CTGGAGCTGG AAAATAGTGT CACCCTGGGT CCCAACCTCC TCCCCATCTG CCTCCCTGAC 
AACGATACCT TCTACGACCT GGGCTTGATG GGCTATGTCA GTGGCTTCGG GGTCATGGAG 
GAGAAGATTG CTCATGACCT CAGGTTTGTC CGTCTGCCCG TAGCTAATCC ACAGGCCTGT 
GAGAACTGGC TCCGGGGAAA GAATAGGATG GATGTGTTCT CTCAAAACAT GTTCTGTGCT 
GGACACCCAT CTCTAAAGCA GGACGCCTGC CAGGGGGATA GTGGGGGCGT TTTTGCAGTA 
AGGGACCCGA ACACTGATCG CTGGGTGGCC ACGGGCATCG TGTCCTGGGG CATCGGGTGC 
AGCAGGGGCT ATGGCTTCTA CACCAAAGTG CTCAACTACG TGGACTGGAT CAAGAAAGAG 
ATGGAGGAGG AGGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

C1R ( NM_001733.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_001724.4 Homo sapiens complement C1r (C1R), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu103328
Clone ID Related Accession (Same CDS sequence)	NM_001733.5 , NM_001733.7
Accession Version	NM_001733.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2118bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-24
Organism	Homo sapiens(human)
Product	complement C1r subcomponent isoform 1 preproprotein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA949107.1, BC035220.1 and AC233309.2. On Aug 29, 2017 this sequence version replaced NM_001733.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC035220.1, SRR1660803.73637.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467144, SAMEA2467148 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGGCTCT TGTACCTCCT GGTGCCGGCC CTGTTCTGCA GGGCAGGAGG CTCCATTCCC 
ATCCCTCAGA AGTTATTTGG GGAGGTGACT TCCCCTCTGT TCCCCAAGCC TTACCCCAAC 
AACTTTGAAA CAACCACTGT GATCACAGTC CCCACGGGAT ACAGGGTGAA GCTCGTCTTC 
CAGCAGTTTG ACCTGGAGCC TTCTGAAGGC TGCTTCTATG ATTATGTCAA GATCTCTGCT 
GATAAGAAAA GCCTGGGGAG GTTCTGTGGG CAACTGGGTT CTCCACTGGG CAACCCCCCG 
GGAAAGAAGG AATTTATGTC CCAAGGGAAC AAGATGCTGC TGACCTTCCA CACAGACTTC 
TCCAACGAGG AGAATGGGAC CATCATGTTC TACAAGGGCT TCCTGGCCTA CTACCAAGCT 
GTGGACCTTG ATGAATGTGC TTCCCGGAGC AAATCAGGGG AGGAGGATCC CCAGCCCCAG 
TGCCAGCACC TGTGTCACAA CTACGTTGGA GGCTACTTCT GTTCCTGCCG TCCAGGCTAT 
GAGCTTCAGG AAGACAGGCA TTCCTGCCAG GCTGAGTGCA GCAGCGAGCT GTACACGGAG 
GCATCAGGCT ACATCTCCAG CCTGGAGTAC CCTCGGTCCT ACCCCCCTGA CCTGCGCTGC 
AACTACAGCA TCCGGGTGGA GCGGGGCCTC ACCCTGCACC TCAAGTTCCT GGAGCCTTTT 
GATATTGATG ACCACCAGCA AGTACACTGC CCCTATGACC AGCTACAGAT CTATGCCAAC 
GGGAAGAACA TTGGCGAGTT CTGTGGGAAG CAAAGGCCCC CCGACCTCGA CACCAGCAGC 
AATGCTGTGG ATCTGCTGTT CTTCACAGAT GAGTCGGGGG ACAGCCGGGG CTGGAAGCTG 
CGCTACACCA CCGAGATCAT CAAGTGCCCC CAGCCCAAGA CCCTAGACGA GTTCACCATC 
ATCCAGAACC TGCAGCCTCA GTACCAGTTC CGTGACTACT TCATTGCTAC CTGCAAGCAA 
GGCTACCAGC TCATAGAGGG GAACCAGGTG CTGCATTCCT TCACAGCTGT CTGCCAGGAT 
GATGGCACGT GGCATCGTGC CATGCCCAGA TGCAAGATCA AGGACTGTGG GCAGCCCCGA 
AACCTGCCTA ATGGTGACTT CCGTTACACC ACCACAATGG GAGTGAACAC CTACAAGGCC 
CGTATCCAGT ACTACTGCCA TGAGCCATAT TACAAGATGC AGACCAGAGC TGGCAGCAGG 
GAGTCTGAGC AAGGGGTGTA CACCTGCACA GCACAGGGCA TTTGGAAGAA TGAACAGAAG 
GGAGAGAAGA TTCCTCGGTG CTTGCCAGTG TGTGGGAAGC CCGTGAACCC CGTGGAACAG 
AGGCAGCGCA TCATCGGAGG GCAAAAAGCC AAGATGGGCA ACTTCCCCTG GCAGGTGTTC 
ACCAACATCC ACGGGCGCGG GGGCGGGGCC CTGCTGGGCG ACCGCTGGAT CCTCACAGCT 
GCCCACACCC TGTATCCCAA GGAACACGAA GCGCAAAGCA ACGCCTCTTT GGATGTGTTC 
CTGGGCCACA CAAATGTGGA AGAGCTCATG AAGCTAGGAA ATCACCCCAT CCGCAGGGTC 
AGCGTCCACC CGGACTACCG TCAGGATGAG TCCTACAATT TTGAGGGGGA CATCGCCCTG 
CTGGAGCTGG AAAATAGTGT CACCCTGGGT CCCAACCTCC TCCCCATCTG CCTCCCTGAC 
AACGATACCT TCTACGACCT GGGCTTGATG GGCTATGTCA GTGGCTTCGG GGTCATGGAG 
GAGAAGATTG CTCATGACCT CAGGTTTGTC CGTCTGCCCG TAGCTAATCC ACAGGCCTGT 
GAGAACTGGC TCCGGGGAAA GAATAGGATG GATGTGTTCT CTCAAAACAT GTTCTGTGCT 
GGACACCCAT CTCTAAAGCA GGACGCCTGC CAGGGGGATA GTGGGGGCGT TTTTGCAGTA 
AGGGACCCGA ACACTGATCG CTGGGTGGCC ACGGGCATCG TGTCCTGGGG CATCGGGTGC 
AGCAGGGGCT ATGGCTTCTA CACCAAAGTG CTCAACTACG TGGACTGGAT CAAGAAAGAG 
ATGGAGGAGG AGGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001724.4
CDS	220..2337
Translation	MWLLYLLVPALFCRAGGSIPIPQKLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCFYDYVKISADKKSLGRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDFSNEENGTIMFYKGFLAYYQAVDLDECASRSKSGEEDPQPQCQHLCHNYVGGYFCSCRPGYELQEDRHSCQAECSSELYTEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPFDIDDHQQVHCPYDQLQIYANGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLRYTTEIIKCPQPKTLDEFTIIQNLQPQYQFRDYFIATCKQGYQLIEGNQVLHSFTAVCQDDGTWHRAMPRCKIKDCGQPRNLPNGDFRYTTTMGVNTYKARIQYYCHEPYYKMQTRAGSRESEQGVYTCTAQGIWKNEQKGEKIPRCLPVCGKPVNPVEQRQRIIGGQKAKMGNFPWQVFTNIHGRGGGALLGDRWILTAAHTLYPKEHEAQSNASLDVFLGHTNVEELMKLGNHPIRRVSVHPDYRQDESYNFEGDIALLELENSVTLGPNLLPICLPDNDTFYDLGLMGYVSGFGVMEEKIAHDLRFVRLPVANPQACENWLRGKNRMDVFSQNMFCAGHPSLKQDACQGDSGGVFAVRDPNTDRWVATGIVSWGIGCSRGYGFYTKVLNYVDWIKKEMEEED

Target ORF information:

RefSeq Version	NM_001733.5
Organism	Homo sapiens(human)
Definition	Homo sapiens complement C1r (C1R), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001733.5

ORF Insert Sequence:

ATGTGGCTCT TGTACCTCCT GGTGCCGGCC CTGTTCTGCA GGGCAGGAGG CTCCATTCCC 
ATCCCTCAGA AGTTATTTGG GGAGGTGACT TCCCCTCTGT TCCCCAAGCC TTACCCCAAC 
AACTTTGAAA CAACCACTGT GATCACAGTC CCCACGGGAT ACAGGGTGAA GCTCGTCTTC 
CAGCAGTTTG ACCTGGAGCC TTCTGAAGGC TGCTTCTATG ATTATGTCAA GATCTCTGCT 
GATAAGAAAA GCCTGGGGAG GTTCTGTGGG CAACTGGGTT CTCCACTGGG CAACCCCCCG 
GGAAAGAAGG AATTTATGTC CCAAGGGAAC AAGATGCTGC TGACCTTCCA CACAGACTTC 
TCCAACGAGG AGAATGGGAC CATCATGTTC TACAAGGGCT TCCTGGCCTA CTACCAAGCT 
GTGGACCTTG ATGAATGTGC TTCCCGGAGC AAATCAGGGG AGGAGGATCC CCAGCCCCAG 
TGCCAGCACC TGTGTCACAA CTACGTTGGA GGCTACTTCT GTTCCTGCCG TCCAGGCTAT 
GAGCTTCAGG AAGACAGGCA TTCCTGCCAG GCTGAGTGCA GCAGCGAGCT GTACACGGAG 
GCATCAGGCT ACATCTCCAG CCTGGAGTAC CCTCGGTCCT ACCCCCCTGA CCTGCGCTGC 
AACTACAGCA TCCGGGTGGA GCGGGGCCTC ACCCTGCACC TCAAGTTCCT GGAGCCTTTT 
GATATTGATG ACCACCAGCA AGTACACTGC CCCTATGACC AGCTACAGAT CTATGCCAAC 
GGGAAGAACA TTGGCGAGTT CTGTGGGAAG CAAAGGCCCC CCGACCTCGA CACCAGCAGC 
AATGCTGTGG ATCTGCTGTT CTTCACAGAT GAGTCGGGGG ACAGCCGGGG CTGGAAGCTG 
CGCTACACCA CCGAGATCAT CAAGTGCCCC CAGCCCAAGA CCCTAGACGA GTTCACCATC 
ATCCAGAACC TGCAGCCTCA GTACCAGTTC CGTGACTACT TCATTGCTAC CTGCAAGCAA 
GGCTACCAGC TCATAGAGGG GAACCAGGTG CTGCATTCCT TCACAGCTGT CTGCCAGGAT 
GATGGCACGT GGCATCGTGC CATGCCCAGA TGCAAGATCA AGGACTGTGG GCAGCCCCGA 
AACCTGCCTA ATGGTGACTT CCGTTACACC ACCACAATGG GAGTGAACAC CTACAAGGCC 
CGTATCCAGT ACTACTGCCA TGAGCCATAT TACAAGATGC AGACCAGAGC TGGCAGCAGG 
GAGTCTGAGC AAGGGGTGTA CACCTGCACA GCACAGGGCA TTTGGAAGAA TGAACAGAAG 
GGAGAGAAGA TTCCTCGGTG CTTGCCAGTG TGTGGGAAGC CCGTGAACCC CGTGGAACAG 
AGGCAGCGCA TCATCGGAGG GCAAAAAGCC AAGATGGGCA ACTTCCCCTG GCAGGTGTTC 
ACCAACATCC ACGGGCGCGG GGGCGGGGCC CTGCTGGGCG ACCGCTGGAT CCTCACAGCT 
GCCCACACCC TGTATCCCAA GGAACACGAA GCGCAAAGCA ACGCCTCTTT GGATGTGTTC 
CTGGGCCACA CAAATGTGGA AGAGCTCATG AAGCTAGGAA ATCACCCCAT CCGCAGGGTC 
AGCGTCCACC CGGACTACCG TCAGGATGAG TCCTACAATT TTGAGGGGGA CATCGCCCTG 
CTGGAGCTGG AAAATAGTGT CACCCTGGGT CCCAACCTCC TCCCCATCTG CCTCCCTGAC 
AACGATACCT TCTACGACCT GGGCTTGATG GGCTATGTCA GTGGCTTCGG GGTCATGGAG 
GAGAAGATTG CTCATGACCT CAGGTTTGTC CGTCTGCCCG TAGCTAATCC ACAGGCCTGT 
GAGAACTGGC TCCGGGGAAA GAATAGGATG GATGTGTTCT CTCAAAACAT GTTCTGTGCT 
GGACACCCAT CTCTAAAGCA GGACGCCTGC CAGGGGGATA GTGGGGGCGT TTTTGCAGTA 
AGGGACCCGA ACACTGATCG CTGGGTGGCC ACGGGCATCG TGTCCTGGGG CATCGGGTGC 
AGCAGGGGCT ATGGCTTCTA CACCAAAGTG CTCAACTACG TGGACTGGAT CAAGAAAGAG 
ATGGAGGAGG AGGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

C1R ( NM_001733.7 ) cDNA ORF clone, Homo sapiens(human) -> NP_001724.4 Homo sapiens complement C1r (C1R), transcript variant 1, mRNA.

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CloneID	OHu103328
Clone ID Related Accession (Same CDS sequence)	NM_001733.5 , NM_001733.7
Accession Version	NM_001733.7 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2118bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	complement C1r subcomponent isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC035220.1 and M14058.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_001733.6. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC035220.1, SRR1803617.180836.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467144, SAMEA2467148 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000647956.2/ ENSP00000497341.1 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTGGCTCT TGTACCTCCT GGTGCCGGCC CTGTTCTGCA GGGCAGGAGG CTCCATTCCC 
ATCCCTCAGA AGTTATTTGG GGAGGTGACT TCCCCTCTGT TCCCCAAGCC TTACCCCAAC 
AACTTTGAAA CAACCACTGT GATCACAGTC CCCACGGGAT ACAGGGTGAA GCTCGTCTTC 
CAGCAGTTTG ACCTGGAGCC TTCTGAAGGC TGCTTCTATG ATTATGTCAA GATCTCTGCT 
GATAAGAAAA GCCTGGGGAG GTTCTGTGGG CAACTGGGTT CTCCACTGGG CAACCCCCCG 
GGAAAGAAGG AATTTATGTC CCAAGGGAAC AAGATGCTGC TGACCTTCCA CACAGACTTC 
TCCAACGAGG AGAATGGGAC CATCATGTTC TACAAGGGCT TCCTGGCCTA CTACCAAGCT 
GTGGACCTTG ATGAATGTGC TTCCCGGAGC AAATCAGGGG AGGAGGATCC CCAGCCCCAG 
TGCCAGCACC TGTGTCACAA CTACGTTGGA GGCTACTTCT GTTCCTGCCG TCCAGGCTAT 
GAGCTTCAGG AAGACAGGCA TTCCTGCCAG GCTGAGTGCA GCAGCGAGCT GTACACGGAG 
GCATCAGGCT ACATCTCCAG CCTGGAGTAC CCTCGGTCCT ACCCCCCTGA CCTGCGCTGC 
AACTACAGCA TCCGGGTGGA GCGGGGCCTC ACCCTGCACC TCAAGTTCCT GGAGCCTTTT 
GATATTGATG ACCACCAGCA AGTACACTGC CCCTATGACC AGCTACAGAT CTATGCCAAC 
GGGAAGAACA TTGGCGAGTT CTGTGGGAAG CAAAGGCCCC CCGACCTCGA CACCAGCAGC 
AATGCTGTGG ATCTGCTGTT CTTCACAGAT GAGTCGGGGG ACAGCCGGGG CTGGAAGCTG 
CGCTACACCA CCGAGATCAT CAAGTGCCCC CAGCCCAAGA CCCTAGACGA GTTCACCATC 
ATCCAGAACC TGCAGCCTCA GTACCAGTTC CGTGACTACT TCATTGCTAC CTGCAAGCAA 
GGCTACCAGC TCATAGAGGG GAACCAGGTG CTGCATTCCT TCACAGCTGT CTGCCAGGAT 
GATGGCACGT GGCATCGTGC CATGCCCAGA TGCAAGATCA AGGACTGTGG GCAGCCCCGA 
AACCTGCCTA ATGGTGACTT CCGTTACACC ACCACAATGG GAGTGAACAC CTACAAGGCC 
CGTATCCAGT ACTACTGCCA TGAGCCATAT TACAAGATGC AGACCAGAGC TGGCAGCAGG 
GAGTCTGAGC AAGGGGTGTA CACCTGCACA GCACAGGGCA TTTGGAAGAA TGAACAGAAG 
GGAGAGAAGA TTCCTCGGTG CTTGCCAGTG TGTGGGAAGC CCGTGAACCC CGTGGAACAG 
AGGCAGCGCA TCATCGGAGG GCAAAAAGCC AAGATGGGCA ACTTCCCCTG GCAGGTGTTC 
ACCAACATCC ACGGGCGCGG GGGCGGGGCC CTGCTGGGCG ACCGCTGGAT CCTCACAGCT 
GCCCACACCC TGTATCCCAA GGAACACGAA GCGCAAAGCA ACGCCTCTTT GGATGTGTTC 
CTGGGCCACA CAAATGTGGA AGAGCTCATG AAGCTAGGAA ATCACCCCAT CCGCAGGGTC 
AGCGTCCACC CGGACTACCG TCAGGATGAG TCCTACAATT TTGAGGGGGA CATCGCCCTG 
CTGGAGCTGG AAAATAGTGT CACCCTGGGT CCCAACCTCC TCCCCATCTG CCTCCCTGAC 
AACGATACCT TCTACGACCT GGGCTTGATG GGCTATGTCA GTGGCTTCGG GGTCATGGAG 
GAGAAGATTG CTCATGACCT CAGGTTTGTC CGTCTGCCCG TAGCTAATCC ACAGGCCTGT 
GAGAACTGGC TCCGGGGAAA GAATAGGATG GATGTGTTCT CTCAAAACAT GTTCTGTGCT 
GGACACCCAT CTCTAAAGCA GGACGCCTGC CAGGGGGATA GTGGGGGCGT TTTTGCAGTA 
AGGGACCCGA ACACTGATCG CTGGGTGGCC ACGGGCATCG TGTCCTGGGG CATCGGGTGC 
AGCAGGGGCT ATGGCTTCTA CACCAAAGTG CTCAACTACG TGGACTGGAT CAAGAAAGAG 
ATGGAGGAGG AGGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001724.4
CDS	58..2175
Translation	MWLLYLLVPALFCRAGGSIPIPQKLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCFYDYVKISADKKSLGRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDFSNEENGTIMFYKGFLAYYQAVDLDECASRSKSGEEDPQPQCQHLCHNYVGGYFCSCRPGYELQEDRHSCQAECSSELYTEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPFDIDDHQQVHCPYDQLQIYANGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLRYTTEIIKCPQPKTLDEFTIIQNLQPQYQFRDYFIATCKQGYQLIEGNQVLHSFTAVCQDDGTWHRAMPRCKIKDCGQPRNLPNGDFRYTTTMGVNTYKARIQYYCHEPYYKMQTRAGSRESEQGVYTCTAQGIWKNEQKGEKIPRCLPVCGKPVNPVEQRQRIIGGQKAKMGNFPWQVFTNIHGRGGGALLGDRWILTAAHTLYPKEHEAQSNASLDVFLGHTNVEELMKLGNHPIRRVSVHPDYRQDESYNFEGDIALLELENSVTLGPNLLPICLPDNDTFYDLGLMGYVSGFGVMEEKIAHDLRFVRLPVANPQACENWLRGKNRMDVFSQNMFCAGHPSLKQDACQGDSGGVFAVRDPNTDRWVATGIVSWGIGCSRGYGFYTKVLNYVDWIKKEMEEED

Target ORF information:

RefSeq Version	NM_001733.7
Organism	Homo sapiens(human)
Definition	Homo sapiens complement C1r (C1R), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001733.7

ORF Insert Sequence:

ATGTGGCTCT TGTACCTCCT GGTGCCGGCC CTGTTCTGCA GGGCAGGAGG CTCCATTCCC 
ATCCCTCAGA AGTTATTTGG GGAGGTGACT TCCCCTCTGT TCCCCAAGCC TTACCCCAAC 
AACTTTGAAA CAACCACTGT GATCACAGTC CCCACGGGAT ACAGGGTGAA GCTCGTCTTC 
CAGCAGTTTG ACCTGGAGCC TTCTGAAGGC TGCTTCTATG ATTATGTCAA GATCTCTGCT 
GATAAGAAAA GCCTGGGGAG GTTCTGTGGG CAACTGGGTT CTCCACTGGG CAACCCCCCG 
GGAAAGAAGG AATTTATGTC CCAAGGGAAC AAGATGCTGC TGACCTTCCA CACAGACTTC 
TCCAACGAGG AGAATGGGAC CATCATGTTC TACAAGGGCT TCCTGGCCTA CTACCAAGCT 
GTGGACCTTG ATGAATGTGC TTCCCGGAGC AAATCAGGGG AGGAGGATCC CCAGCCCCAG 
TGCCAGCACC TGTGTCACAA CTACGTTGGA GGCTACTTCT GTTCCTGCCG TCCAGGCTAT 
GAGCTTCAGG AAGACAGGCA TTCCTGCCAG GCTGAGTGCA GCAGCGAGCT GTACACGGAG 
GCATCAGGCT ACATCTCCAG CCTGGAGTAC CCTCGGTCCT ACCCCCCTGA CCTGCGCTGC 
AACTACAGCA TCCGGGTGGA GCGGGGCCTC ACCCTGCACC TCAAGTTCCT GGAGCCTTTT 
GATATTGATG ACCACCAGCA AGTACACTGC CCCTATGACC AGCTACAGAT CTATGCCAAC 
GGGAAGAACA TTGGCGAGTT CTGTGGGAAG CAAAGGCCCC CCGACCTCGA CACCAGCAGC 
AATGCTGTGG ATCTGCTGTT CTTCACAGAT GAGTCGGGGG ACAGCCGGGG CTGGAAGCTG 
CGCTACACCA CCGAGATCAT CAAGTGCCCC CAGCCCAAGA CCCTAGACGA GTTCACCATC 
ATCCAGAACC TGCAGCCTCA GTACCAGTTC CGTGACTACT TCATTGCTAC CTGCAAGCAA 
GGCTACCAGC TCATAGAGGG GAACCAGGTG CTGCATTCCT TCACAGCTGT CTGCCAGGAT 
GATGGCACGT GGCATCGTGC CATGCCCAGA TGCAAGATCA AGGACTGTGG GCAGCCCCGA 
AACCTGCCTA ATGGTGACTT CCGTTACACC ACCACAATGG GAGTGAACAC CTACAAGGCC 
CGTATCCAGT ACTACTGCCA TGAGCCATAT TACAAGATGC AGACCAGAGC TGGCAGCAGG 
GAGTCTGAGC AAGGGGTGTA CACCTGCACA GCACAGGGCA TTTGGAAGAA TGAACAGAAG 
GGAGAGAAGA TTCCTCGGTG CTTGCCAGTG TGTGGGAAGC CCGTGAACCC CGTGGAACAG 
AGGCAGCGCA TCATCGGAGG GCAAAAAGCC AAGATGGGCA ACTTCCCCTG GCAGGTGTTC 
ACCAACATCC ACGGGCGCGG GGGCGGGGCC CTGCTGGGCG ACCGCTGGAT CCTCACAGCT 
GCCCACACCC TGTATCCCAA GGAACACGAA GCGCAAAGCA ACGCCTCTTT GGATGTGTTC 
CTGGGCCACA CAAATGTGGA AGAGCTCATG AAGCTAGGAA ATCACCCCAT CCGCAGGGTC 
AGCGTCCACC CGGACTACCG TCAGGATGAG TCCTACAATT TTGAGGGGGA CATCGCCCTG 
CTGGAGCTGG AAAATAGTGT CACCCTGGGT CCCAACCTCC TCCCCATCTG CCTCCCTGAC 
AACGATACCT TCTACGACCT GGGCTTGATG GGCTATGTCA GTGGCTTCGG GGTCATGGAG 
GAGAAGATTG CTCATGACCT CAGGTTTGTC CGTCTGCCCG TAGCTAATCC ACAGGCCTGT 
GAGAACTGGC TCCGGGGAAA GAATAGGATG GATGTGTTCT CTCAAAACAT GTTCTGTGCT 
GGACACCCAT CTCTAAAGCA GGACGCCTGC CAGGGGGATA GTGGGGGCGT TTTTGCAGTA 
AGGGACCCGA ACACTGATCG CTGGGTGGCC ACGGGCATCG TGTCCTGGGG CATCGGGTGC 
AGCAGGGGCT ATGGCTTCTA CACCAAAGTG CTCAACTACG TGGACTGGAT CAAGAAAGAG 
ATGGAGGAGG AGGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

C1R ( NM_001354346.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001341275.1 Homo sapiens complement C1r (C1R), transcript variant 2, mRNA.

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CloneID	OHu84130
Clone ID Related Accession (Same CDS sequence)	NM_001354346.2 , XM_017019915.1 , NM_001354346.1
Accession Version	NM_001354346.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2160bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	complement C1r subcomponent isoform 2 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC233309.2, AK298445.1 and BC035220.1. On May 31, 2019 this sequence version replaced NM_001354346.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.259075.1, AK298445.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467144, SAMN04284274 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCTGTGA GGTTCAGGGT GGGCAGAGAG GAGAATGCCC AGTGGTGGCT CTTGTACCTC 
CTGGTGCCGG CCCTGTTCTG CAGGGCAGGA GGCTCCATTC CCATCCCTCA GAAGTTATTT 
GGGGAGGTGA CTTCCCCTCT GTTCCCCAAG CCTTACCCCA ACAACTTTGA AACAACCACT 
GTGATCACAG TCCCCACGGG ATACAGGGTG AAGCTCGTCT TCCAGCAGTT TGACCTGGAG 
CCTTCTGAAG GCTGCTTCTA TGATTATGTC AAGATCTCTG CTGATAAGAA AAGCCTGGGG 
AGGTTCTGTG GGCAACTGGG TTCTCCACTG GGCAACCCCC CGGGAAAGAA GGAATTTATG 
TCCCAAGGGA ACAAGATGCT GCTGACCTTC CACACAGACT TCTCCAACGA GGAGAATGGG 
ACCATCATGT TCTACAAGGG CTTCCTGGCC TACTACCAAG CTGTGGACCT TGATGAATGT 
GCTTCCCGGA GCAAATCAGG GGAGGAGGAT CCCCAGCCCC AGTGCCAGCA CCTGTGTCAC 
AACTACGTTG GAGGCTACTT CTGTTCCTGC CGTCCAGGCT ATGAGCTTCA GGAAGACAGG 
CATTCCTGCC AGGCTGAGTG CAGCAGCGAG CTGTACACGG AGGCATCAGG CTACATCTCC 
AGCCTGGAGT ACCCTCGGTC CTACCCCCCT GACCTGCGCT GCAACTACAG CATCCGGGTG 
GAGCGGGGCC TCACCCTGCA CCTCAAGTTC CTGGAGCCTT TTGATATTGA TGACCACCAG 
CAAGTACACT GCCCCTATGA CCAGCTACAG ATCTATGCCA ACGGGAAGAA CATTGGCGAG 
TTCTGTGGGA AGCAAAGGCC CCCCGACCTC GACACCAGCA GCAATGCTGT GGATCTGCTG 
TTCTTCACAG ATGAGTCGGG GGACAGCCGG GGCTGGAAGC TGCGCTACAC CACCGAGATC 
ATCAAGTGCC CCCAGCCCAA GACCCTAGAC GAGTTCACCA TCATCCAGAA CCTGCAGCCT 
CAGTACCAGT TCCGTGACTA CTTCATTGCT ACCTGCAAGC AAGGCTACCA GCTCATAGAG 
GGGAACCAGG TGCTGCATTC CTTCACAGCT GTCTGCCAGG ATGATGGCAC GTGGCATCGT 
GCCATGCCCA GATGCAAGAT CAAGGACTGT GGGCAGCCCC GAAACCTGCC TAATGGTGAC 
TTCCGTTACA CCACCACAAT GGGAGTGAAC ACCTACAAGG CCCGTATCCA GTACTACTGC 
CATGAGCCAT ATTACAAGAT GCAGACCAGA GCTGGCAGCA GGGAGTCTGA GCAAGGGGTG 
TACACCTGCA CAGCACAGGG CATTTGGAAG AATGAACAGA AGGGAGAGAA GATTCCTCGG 
TGCTTGCCAG TGTGTGGGAA GCCCGTGAAC CCCGTGGAAC AGAGGCAGCG CATCATCGGA 
GGGCAAAAAG CCAAGATGGG CAACTTCCCC TGGCAGGTGT TCACCAACAT CCACGGGCGC 
GGGGGCGGGG CCCTGCTGGG CGACCGCTGG ATCCTCACAG CTGCCCACAC CCTGTATCCC 
AAGGAACACG AAGCGCAAAG CAACGCCTCT TTGGATGTGT TCCTGGGCCA CACAAATGTG 
GAAGAGCTCA TGAAGCTAGG AAATCACCCC ATCCGCAGGG TCAGCGTCCA CCCGGACTAC 
CGTCAGGATG AGTCCTACAA TTTTGAGGGG GACATCGCCC TGCTGGAGCT GGAAAATAGT 
GTCACCCTGG GTCCCAACCT CCTCCCCATC TGCCTCCCTG ACAACGATAC CTTCTACGAC 
CTGGGCTTGA TGGGCTATGT CAGTGGCTTC GGGGTCATGG AGGAGAAGAT TGCTCATGAC 
CTCAGGTTTG TCCGTCTGCC CGTAGCTAAT CCACAGGCCT GTGAGAACTG GCTCCGGGGA 
AAGAATAGGA TGGATGTGTT CTCTCAAAAC ATGTTCTGTG CTGGACACCC ATCTCTAAAG 
CAGGACGCCT GCCAGGGGGA TAGTGGGGGC GTTTTTGCAG TAAGGGACCC GAACACTGAT 
CGCTGGGTGG CCACGGGCAT CGTGTCCTGG GGCATCGGGT GCAGCAGGGG CTATGGCTTC 
TACACCAAAG TGCTCAACTA CGTGGACTGG ATCAAGAAAG AGATGGAGGA GGAGGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001341275.1
CDS	78..2237
Translation	MSVRFRVGREENAQWWLLYLLVPALFCRAGGSIPIPQKLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCFYDYVKISADKKSLGRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDFSNEENGTIMFYKGFLAYYQAVDLDECASRSKSGEEDPQPQCQHLCHNYVGGYFCSCRPGYELQEDRHSCQAECSSELYTEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPFDIDDHQQVHCPYDQLQIYANGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLRYTTEIIKCPQPKTLDEFTIIQNLQPQYQFRDYFIATCKQGYQLIEGNQVLHSFTAVCQDDGTWHRAMPRCKIKDCGQPRNLPNGDFRYTTTMGVNTYKARIQYYCHEPYYKMQTRAGSRESEQGVYTCTAQGIWKNEQKGEKIPRCLPVCGKPVNPVEQRQRIIGGQKAKMGNFPWQVFTNIHGRGGGALLGDRWILTAAHTLYPKEHEAQSNASLDVFLGHTNVEELMKLGNHPIRRVSVHPDYRQDESYNFEGDIALLELENSVTLGPNLLPICLPDNDTFYDLGLMGYVSGFGVMEEKIAHDLRFVRLPVANPQACENWLRGKNRMDVFSQNMFCAGHPSLKQDACQGDSGGVFAVRDPNTDRWVATGIVSWGIGCSRGYGFYTKVLNYVDWIKKEMEEED

Target ORF information:

RefSeq Version	NM_001354346.2
Organism	Homo sapiens(human)
Definition	Homo sapiens complement C1r (C1R), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001354346.2

ORF Insert Sequence:

ATGTCTGTGA GGTTCAGGGT GGGCAGAGAG GAGAATGCCC AGTGGTGGCT CTTGTACCTC 
CTGGTGCCGG CCCTGTTCTG CAGGGCAGGA GGCTCCATTC CCATCCCTCA GAAGTTATTT 
GGGGAGGTGA CTTCCCCTCT GTTCCCCAAG CCTTACCCCA ACAACTTTGA AACAACCACT 
GTGATCACAG TCCCCACGGG ATACAGGGTG AAGCTCGTCT TCCAGCAGTT TGACCTGGAG 
CCTTCTGAAG GCTGCTTCTA TGATTATGTC AAGATCTCTG CTGATAAGAA AAGCCTGGGG 
AGGTTCTGTG GGCAACTGGG TTCTCCACTG GGCAACCCCC CGGGAAAGAA GGAATTTATG 
TCCCAAGGGA ACAAGATGCT GCTGACCTTC CACACAGACT TCTCCAACGA GGAGAATGGG 
ACCATCATGT TCTACAAGGG CTTCCTGGCC TACTACCAAG CTGTGGACCT TGATGAATGT 
GCTTCCCGGA GCAAATCAGG GGAGGAGGAT CCCCAGCCCC AGTGCCAGCA CCTGTGTCAC 
AACTACGTTG GAGGCTACTT CTGTTCCTGC CGTCCAGGCT ATGAGCTTCA GGAAGACAGG 
CATTCCTGCC AGGCTGAGTG CAGCAGCGAG CTGTACACGG AGGCATCAGG CTACATCTCC 
AGCCTGGAGT ACCCTCGGTC CTACCCCCCT GACCTGCGCT GCAACTACAG CATCCGGGTG 
GAGCGGGGCC TCACCCTGCA CCTCAAGTTC CTGGAGCCTT TTGATATTGA TGACCACCAG 
CAAGTACACT GCCCCTATGA CCAGCTACAG ATCTATGCCA ACGGGAAGAA CATTGGCGAG 
TTCTGTGGGA AGCAAAGGCC CCCCGACCTC GACACCAGCA GCAATGCTGT GGATCTGCTG 
TTCTTCACAG ATGAGTCGGG GGACAGCCGG GGCTGGAAGC TGCGCTACAC CACCGAGATC 
ATCAAGTGCC CCCAGCCCAA GACCCTAGAC GAGTTCACCA TCATCCAGAA CCTGCAGCCT 
CAGTACCAGT TCCGTGACTA CTTCATTGCT ACCTGCAAGC AAGGCTACCA GCTCATAGAG 
GGGAACCAGG TGCTGCATTC CTTCACAGCT GTCTGCCAGG ATGATGGCAC GTGGCATCGT 
GCCATGCCCA GATGCAAGAT CAAGGACTGT GGGCAGCCCC GAAACCTGCC TAATGGTGAC 
TTCCGTTACA CCACCACAAT GGGAGTGAAC ACCTACAAGG CCCGTATCCA GTACTACTGC 
CATGAGCCAT ATTACAAGAT GCAGACCAGA GCTGGCAGCA GGGAGTCTGA GCAAGGGGTG 
TACACCTGCA CAGCACAGGG CATTTGGAAG AATGAACAGA AGGGAGAGAA GATTCCTCGG 
TGCTTGCCAG TGTGTGGGAA GCCCGTGAAC CCCGTGGAAC AGAGGCAGCG CATCATCGGA 
GGGCAAAAAG CCAAGATGGG CAACTTCCCC TGGCAGGTGT TCACCAACAT CCACGGGCGC 
GGGGGCGGGG CCCTGCTGGG CGACCGCTGG ATCCTCACAG CTGCCCACAC CCTGTATCCC 
AAGGAACACG AAGCGCAAAG CAACGCCTCT TTGGATGTGT TCCTGGGCCA CACAAATGTG 
GAAGAGCTCA TGAAGCTAGG AAATCACCCC ATCCGCAGGG TCAGCGTCCA CCCGGACTAC 
CGTCAGGATG AGTCCTACAA TTTTGAGGGG GACATCGCCC TGCTGGAGCT GGAAAATAGT 
GTCACCCTGG GTCCCAACCT CCTCCCCATC TGCCTCCCTG ACAACGATAC CTTCTACGAC 
CTGGGCTTGA TGGGCTATGT CAGTGGCTTC GGGGTCATGG AGGAGAAGAT TGCTCATGAC 
CTCAGGTTTG TCCGTCTGCC CGTAGCTAAT CCACAGGCCT GTGAGAACTG GCTCCGGGGA 
AAGAATAGGA TGGATGTGTT CTCTCAAAAC ATGTTCTGTG CTGGACACCC ATCTCTAAAG 
CAGGACGCCT GCCAGGGGGA TAGTGGGGGC GTTTTTGCAG TAAGGGACCC GAACACTGAT 
CGCTGGGTGG CCACGGGCAT CGTGTCCTGG GGCATCGGGT GCAGCAGGGG CTATGGCTTC 
TACACCAAAG TGCTCAACTA CGTGGACTGG ATCAAGAAAG AGATGGAGGA GGAGGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

C1R ( NM_001354346.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001341275.1 Homo sapiens complement C1r (C1R), transcript variant 2, mRNA.

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CloneID	OHu84130
Clone ID Related Accession (Same CDS sequence)	NM_001354346.2 , XM_017019915.1 , NM_001354346.1
Accession Version	NM_001354346.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2160bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-26
Organism	Homo sapiens(human)
Product	complement C1r subcomponent isoform 2 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC233309.2, AK298445.1 and BC035220.1. On Aug 29, 2017 this sequence version replaced XM_017019915.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK298445.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467144, SAMN04284274 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCTGTGA GGTTCAGGGT GGGCAGAGAG GAGAATGCCC AGTGGTGGCT CTTGTACCTC 
CTGGTGCCGG CCCTGTTCTG CAGGGCAGGA GGCTCCATTC CCATCCCTCA GAAGTTATTT 
GGGGAGGTGA CTTCCCCTCT GTTCCCCAAG CCTTACCCCA ACAACTTTGA AACAACCACT 
GTGATCACAG TCCCCACGGG ATACAGGGTG AAGCTCGTCT TCCAGCAGTT TGACCTGGAG 
CCTTCTGAAG GCTGCTTCTA TGATTATGTC AAGATCTCTG CTGATAAGAA AAGCCTGGGG 
AGGTTCTGTG GGCAACTGGG TTCTCCACTG GGCAACCCCC CGGGAAAGAA GGAATTTATG 
TCCCAAGGGA ACAAGATGCT GCTGACCTTC CACACAGACT TCTCCAACGA GGAGAATGGG 
ACCATCATGT TCTACAAGGG CTTCCTGGCC TACTACCAAG CTGTGGACCT TGATGAATGT 
GCTTCCCGGA GCAAATCAGG GGAGGAGGAT CCCCAGCCCC AGTGCCAGCA CCTGTGTCAC 
AACTACGTTG GAGGCTACTT CTGTTCCTGC CGTCCAGGCT ATGAGCTTCA GGAAGACAGG 
CATTCCTGCC AGGCTGAGTG CAGCAGCGAG CTGTACACGG AGGCATCAGG CTACATCTCC 
AGCCTGGAGT ACCCTCGGTC CTACCCCCCT GACCTGCGCT GCAACTACAG CATCCGGGTG 
GAGCGGGGCC TCACCCTGCA CCTCAAGTTC CTGGAGCCTT TTGATATTGA TGACCACCAG 
CAAGTACACT GCCCCTATGA CCAGCTACAG ATCTATGCCA ACGGGAAGAA CATTGGCGAG 
TTCTGTGGGA AGCAAAGGCC CCCCGACCTC GACACCAGCA GCAATGCTGT GGATCTGCTG 
TTCTTCACAG ATGAGTCGGG GGACAGCCGG GGCTGGAAGC TGCGCTACAC CACCGAGATC 
ATCAAGTGCC CCCAGCCCAA GACCCTAGAC GAGTTCACCA TCATCCAGAA CCTGCAGCCT 
CAGTACCAGT TCCGTGACTA CTTCATTGCT ACCTGCAAGC AAGGCTACCA GCTCATAGAG 
GGGAACCAGG TGCTGCATTC CTTCACAGCT GTCTGCCAGG ATGATGGCAC GTGGCATCGT 
GCCATGCCCA GATGCAAGAT CAAGGACTGT GGGCAGCCCC GAAACCTGCC TAATGGTGAC 
TTCCGTTACA CCACCACAAT GGGAGTGAAC ACCTACAAGG CCCGTATCCA GTACTACTGC 
CATGAGCCAT ATTACAAGAT GCAGACCAGA GCTGGCAGCA GGGAGTCTGA GCAAGGGGTG 
TACACCTGCA CAGCACAGGG CATTTGGAAG AATGAACAGA AGGGAGAGAA GATTCCTCGG 
TGCTTGCCAG TGTGTGGGAA GCCCGTGAAC CCCGTGGAAC AGAGGCAGCG CATCATCGGA 
GGGCAAAAAG CCAAGATGGG CAACTTCCCC TGGCAGGTGT TCACCAACAT CCACGGGCGC 
GGGGGCGGGG CCCTGCTGGG CGACCGCTGG ATCCTCACAG CTGCCCACAC CCTGTATCCC 
AAGGAACACG AAGCGCAAAG CAACGCCTCT TTGGATGTGT TCCTGGGCCA CACAAATGTG 
GAAGAGCTCA TGAAGCTAGG AAATCACCCC ATCCGCAGGG TCAGCGTCCA CCCGGACTAC 
CGTCAGGATG AGTCCTACAA TTTTGAGGGG GACATCGCCC TGCTGGAGCT GGAAAATAGT 
GTCACCCTGG GTCCCAACCT CCTCCCCATC TGCCTCCCTG ACAACGATAC CTTCTACGAC 
CTGGGCTTGA TGGGCTATGT CAGTGGCTTC GGGGTCATGG AGGAGAAGAT TGCTCATGAC 
CTCAGGTTTG TCCGTCTGCC CGTAGCTAAT CCACAGGCCT GTGAGAACTG GCTCCGGGGA 
AAGAATAGGA TGGATGTGTT CTCTCAAAAC ATGTTCTGTG CTGGACACCC ATCTCTAAAG 
CAGGACGCCT GCCAGGGGGA TAGTGGGGGC GTTTTTGCAG TAAGGGACCC GAACACTGAT 
CGCTGGGTGG CCACGGGCAT CGTGTCCTGG GGCATCGGGT GCAGCAGGGG CTATGGCTTC 
TACACCAAAG TGCTCAACTA CGTGGACTGG ATCAAGAAAG AGATGGAGGA GGAGGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001341275.1
CDS	97..2256
Translation	MSVRFRVGREENAQWWLLYLLVPALFCRAGGSIPIPQKLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCFYDYVKISADKKSLGRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDFSNEENGTIMFYKGFLAYYQAVDLDECASRSKSGEEDPQPQCQHLCHNYVGGYFCSCRPGYELQEDRHSCQAECSSELYTEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPFDIDDHQQVHCPYDQLQIYANGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLRYTTEIIKCPQPKTLDEFTIIQNLQPQYQFRDYFIATCKQGYQLIEGNQVLHSFTAVCQDDGTWHRAMPRCKIKDCGQPRNLPNGDFRYTTTMGVNTYKARIQYYCHEPYYKMQTRAGSRESEQGVYTCTAQGIWKNEQKGEKIPRCLPVCGKPVNPVEQRQRIIGGQKAKMGNFPWQVFTNIHGRGGGALLGDRWILTAAHTLYPKEHEAQSNASLDVFLGHTNVEELMKLGNHPIRRVSVHPDYRQDESYNFEGDIALLELENSVTLGPNLLPICLPDNDTFYDLGLMGYVSGFGVMEEKIAHDLRFVRLPVANPQACENWLRGKNRMDVFSQNMFCAGHPSLKQDACQGDSGGVFAVRDPNTDRWVATGIVSWGIGCSRGYGFYTKVLNYVDWIKKEMEEED

Target ORF information:

RefSeq Version	NM_001354346.1
Organism	Homo sapiens(human)
Definition	Homo sapiens complement C1r (C1R), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001354346.1

ORF Insert Sequence:

ATGTCTGTGA GGTTCAGGGT GGGCAGAGAG GAGAATGCCC AGTGGTGGCT CTTGTACCTC 
CTGGTGCCGG CCCTGTTCTG CAGGGCAGGA GGCTCCATTC CCATCCCTCA GAAGTTATTT 
GGGGAGGTGA CTTCCCCTCT GTTCCCCAAG CCTTACCCCA ACAACTTTGA AACAACCACT 
GTGATCACAG TCCCCACGGG ATACAGGGTG AAGCTCGTCT TCCAGCAGTT TGACCTGGAG 
CCTTCTGAAG GCTGCTTCTA TGATTATGTC AAGATCTCTG CTGATAAGAA AAGCCTGGGG 
AGGTTCTGTG GGCAACTGGG TTCTCCACTG GGCAACCCCC CGGGAAAGAA GGAATTTATG 
TCCCAAGGGA ACAAGATGCT GCTGACCTTC CACACAGACT TCTCCAACGA GGAGAATGGG 
ACCATCATGT TCTACAAGGG CTTCCTGGCC TACTACCAAG CTGTGGACCT TGATGAATGT 
GCTTCCCGGA GCAAATCAGG GGAGGAGGAT CCCCAGCCCC AGTGCCAGCA CCTGTGTCAC 
AACTACGTTG GAGGCTACTT CTGTTCCTGC CGTCCAGGCT ATGAGCTTCA GGAAGACAGG 
CATTCCTGCC AGGCTGAGTG CAGCAGCGAG CTGTACACGG AGGCATCAGG CTACATCTCC 
AGCCTGGAGT ACCCTCGGTC CTACCCCCCT GACCTGCGCT GCAACTACAG CATCCGGGTG 
GAGCGGGGCC TCACCCTGCA CCTCAAGTTC CTGGAGCCTT TTGATATTGA TGACCACCAG 
CAAGTACACT GCCCCTATGA CCAGCTACAG ATCTATGCCA ACGGGAAGAA CATTGGCGAG 
TTCTGTGGGA AGCAAAGGCC CCCCGACCTC GACACCAGCA GCAATGCTGT GGATCTGCTG 
TTCTTCACAG ATGAGTCGGG GGACAGCCGG GGCTGGAAGC TGCGCTACAC CACCGAGATC 
ATCAAGTGCC CCCAGCCCAA GACCCTAGAC GAGTTCACCA TCATCCAGAA CCTGCAGCCT 
CAGTACCAGT TCCGTGACTA CTTCATTGCT ACCTGCAAGC AAGGCTACCA GCTCATAGAG 
GGGAACCAGG TGCTGCATTC CTTCACAGCT GTCTGCCAGG ATGATGGCAC GTGGCATCGT 
GCCATGCCCA GATGCAAGAT CAAGGACTGT GGGCAGCCCC GAAACCTGCC TAATGGTGAC 
TTCCGTTACA CCACCACAAT GGGAGTGAAC ACCTACAAGG CCCGTATCCA GTACTACTGC 
CATGAGCCAT ATTACAAGAT GCAGACCAGA GCTGGCAGCA GGGAGTCTGA GCAAGGGGTG 
TACACCTGCA CAGCACAGGG CATTTGGAAG AATGAACAGA AGGGAGAGAA GATTCCTCGG 
TGCTTGCCAG TGTGTGGGAA GCCCGTGAAC CCCGTGGAAC AGAGGCAGCG CATCATCGGA 
GGGCAAAAAG CCAAGATGGG CAACTTCCCC TGGCAGGTGT TCACCAACAT CCACGGGCGC 
GGGGGCGGGG CCCTGCTGGG CGACCGCTGG ATCCTCACAG CTGCCCACAC CCTGTATCCC 
AAGGAACACG AAGCGCAAAG CAACGCCTCT TTGGATGTGT TCCTGGGCCA CACAAATGTG 
GAAGAGCTCA TGAAGCTAGG AAATCACCCC ATCCGCAGGG TCAGCGTCCA CCCGGACTAC 
CGTCAGGATG AGTCCTACAA TTTTGAGGGG GACATCGCCC TGCTGGAGCT GGAAAATAGT 
GTCACCCTGG GTCCCAACCT CCTCCCCATC TGCCTCCCTG ACAACGATAC CTTCTACGAC 
CTGGGCTTGA TGGGCTATGT CAGTGGCTTC GGGGTCATGG AGGAGAAGAT TGCTCATGAC 
CTCAGGTTTG TCCGTCTGCC CGTAGCTAAT CCACAGGCCT GTGAGAACTG GCTCCGGGGA 
AAGAATAGGA TGGATGTGTT CTCTCAAAAC ATGTTCTGTG CTGGACACCC ATCTCTAAAG 
CAGGACGCCT GCCAGGGGGA TAGTGGGGGC GTTTTTGCAG TAAGGGACCC GAACACTGAT 
CGCTGGGTGG CCACGGGCAT CGTGTCCTGG GGCATCGGGT GCAGCAGGGG CTATGGCTTC 
TACACCAAAG TGCTCAACTA CGTGGACTGG ATCAAGAAAG AGATGGAGGA GGAGGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

C1R ( XM_017019915.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016875404.1 Homo sapiens complement C1r subcomponent (C1R), transcript variant X1, mRNA.

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CloneID	OHu84130
Clone ID Related Accession (Same CDS sequence)	NM_001354346.2 , XM_017019915.1 , NM_001354346.1
Accession Version	XM_017019915.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2160bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(Human)
Product	complement C1r subcomponent isoform X1
Comment	MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCTGTGA GGTTCAGGGT GGGCAGAGAG GAGAATGCCC AGTGGTGGCT CTTGTACCTC 
CTGGTGCCGG CCCTGTTCTG CAGGGCAGGA GGCTCCATTC CCATCCCTCA GAAGTTATTT 
GGGGAGGTGA CTTCCCCTCT GTTCCCCAAG CCTTACCCCA ACAACTTTGA AACAACCACT 
GTGATCACAG TCCCCACGGG ATACAGGGTG AAGCTCGTCT TCCAGCAGTT TGACCTGGAG 
CCTTCTGAAG GCTGCTTCTA TGATTATGTC AAGATCTCTG CTGATAAGAA AAGCCTGGGG 
AGGTTCTGTG GGCAACTGGG TTCTCCACTG GGCAACCCCC CGGGAAAGAA GGAATTTATG 
TCCCAAGGGA ACAAGATGCT GCTGACCTTC CACACAGACT TCTCCAACGA GGAGAATGGG 
ACCATCATGT TCTACAAGGG CTTCCTGGCC TACTACCAAG CTGTGGACCT TGATGAATGT 
GCTTCCCGGA GCAAATCAGG GGAGGAGGAT CCCCAGCCCC AGTGCCAGCA CCTGTGTCAC 
AACTACGTTG GAGGCTACTT CTGTTCCTGC CGTCCAGGCT ATGAGCTTCA GGAAGACAGG 
CATTCCTGCC AGGCTGAGTG CAGCAGCGAG CTGTACACGG AGGCATCAGG CTACATCTCC 
AGCCTGGAGT ACCCTCGGTC CTACCCCCCT GACCTGCGCT GCAACTACAG CATCCGGGTG 
GAGCGGGGCC TCACCCTGCA CCTCAAGTTC CTGGAGCCTT TTGATATTGA TGACCACCAG 
CAAGTACACT GCCCCTATGA CCAGCTACAG ATCTATGCCA ACGGGAAGAA CATTGGCGAG 
TTCTGTGGGA AGCAAAGGCC CCCCGACCTC GACACCAGCA GCAATGCTGT GGATCTGCTG 
TTCTTCACAG ATGAGTCGGG GGACAGCCGG GGCTGGAAGC TGCGCTACAC CACCGAGATC 
ATCAAGTGCC CCCAGCCCAA GACCCTAGAC GAGTTCACCA TCATCCAGAA CCTGCAGCCT 
CAGTACCAGT TCCGTGACTA CTTCATTGCT ACCTGCAAGC AAGGCTACCA GCTCATAGAG 
GGGAACCAGG TGCTGCATTC CTTCACAGCT GTCTGCCAGG ATGATGGCAC GTGGCATCGT 
GCCATGCCCA GATGCAAGAT CAAGGACTGT GGGCAGCCCC GAAACCTGCC TAATGGTGAC 
TTCCGTTACA CCACCACAAT GGGAGTGAAC ACCTACAAGG CCCGTATCCA GTACTACTGC 
CATGAGCCAT ATTACAAGAT GCAGACCAGA GCTGGCAGCA GGGAGTCTGA GCAAGGGGTG 
TACACCTGCA CAGCACAGGG CATTTGGAAG AATGAACAGA AGGGAGAGAA GATTCCTCGG 
TGCTTGCCAG TGTGTGGGAA GCCCGTGAAC CCCGTGGAAC AGAGGCAGCG CATCATCGGA 
GGGCAAAAAG CCAAGATGGG CAACTTCCCC TGGCAGGTGT TCACCAACAT CCACGGGCGC 
GGGGGCGGGG CCCTGCTGGG CGACCGCTGG ATCCTCACAG CTGCCCACAC CCTGTATCCC 
AAGGAACACG AAGCGCAAAG CAACGCCTCT TTGGATGTGT TCCTGGGCCA CACAAATGTG 
GAAGAGCTCA TGAAGCTAGG AAATCACCCC ATCCGCAGGG TCAGCGTCCA CCCGGACTAC 
CGTCAGGATG AGTCCTACAA TTTTGAGGGG GACATCGCCC TGCTGGAGCT GGAAAATAGT 
GTCACCCTGG GTCCCAACCT CCTCCCCATC TGCCTCCCTG ACAACGATAC CTTCTACGAC 
CTGGGCTTGA TGGGCTATGT CAGTGGCTTC GGGGTCATGG AGGAGAAGAT TGCTCATGAC 
CTCAGGTTTG TCCGTCTGCC CGTAGCTAAT CCACAGGCCT GTGAGAACTG GCTCCGGGGA 
AAGAATAGGA TGGATGTGTT CTCTCAAAAC ATGTTCTGTG CTGGACACCC ATCTCTAAAG 
CAGGACGCCT GCCAGGGGGA TAGTGGGGGC GTTTTTGCAG TAAGGGACCC GAACACTGAT 
CGCTGGGTGG CCACGGGCAT CGTGTCCTGG GGCATCGGGT GCAGCAGGGG CTATGGCTTC 
TACACCAAAG TGCTCAACTA CGTGGACTGG ATCAAGAAAG AGATGGAGGA GGAGGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016875404.1
CDS	92..2251
Translation	MSVRFRVGREENAQWWLLYLLVPALFCRAGGSIPIPQKLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCFYDYVKISADKKSLGRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDFSNEENGTIMFYKGFLAYYQAVDLDECASRSKSGEEDPQPQCQHLCHNYVGGYFCSCRPGYELQEDRHSCQAECSSELYTEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPFDIDDHQQVHCPYDQLQIYANGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLRYTTEIIKCPQPKTLDEFTIIQNLQPQYQFRDYFIATCKQGYQLIEGNQVLHSFTAVCQDDGTWHRAMPRCKIKDCGQPRNLPNGDFRYTTTMGVNTYKARIQYYCHEPYYKMQTRAGSRESEQGVYTCTAQGIWKNEQKGEKIPRCLPVCGKPVNPVEQRQRIIGGQKAKMGNFPWQVFTNIHGRGGGALLGDRWILTAAHTLYPKEHEAQSNASLDVFLGHTNVEELMKLGNHPIRRVSVHPDYRQDESYNFEGDIALLELENSVTLGPNLLPICLPDNDTFYDLGLMGYVSGFGVMEEKIAHDLRFVRLPVANPQACENWLRGKNRMDVFSQNMFCAGHPSLKQDACQGDSGGVFAVRDPNTDRWVATGIVSWGIGCSRGYGFYTKVLNYVDWIKKEMEEED

Target ORF information:

RefSeq Version	XM_017019915.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens complement C1r subcomponent (C1R), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017019915.1

ORF Insert Sequence:

ATGTCTGTGA GGTTCAGGGT GGGCAGAGAG GAGAATGCCC AGTGGTGGCT CTTGTACCTC 
CTGGTGCCGG CCCTGTTCTG CAGGGCAGGA GGCTCCATTC CCATCCCTCA GAAGTTATTT 
GGGGAGGTGA CTTCCCCTCT GTTCCCCAAG CCTTACCCCA ACAACTTTGA AACAACCACT 
GTGATCACAG TCCCCACGGG ATACAGGGTG AAGCTCGTCT TCCAGCAGTT TGACCTGGAG 
CCTTCTGAAG GCTGCTTCTA TGATTATGTC AAGATCTCTG CTGATAAGAA AAGCCTGGGG 
AGGTTCTGTG GGCAACTGGG TTCTCCACTG GGCAACCCCC CGGGAAAGAA GGAATTTATG 
TCCCAAGGGA ACAAGATGCT GCTGACCTTC CACACAGACT TCTCCAACGA GGAGAATGGG 
ACCATCATGT TCTACAAGGG CTTCCTGGCC TACTACCAAG CTGTGGACCT TGATGAATGT 
GCTTCCCGGA GCAAATCAGG GGAGGAGGAT CCCCAGCCCC AGTGCCAGCA CCTGTGTCAC 
AACTACGTTG GAGGCTACTT CTGTTCCTGC CGTCCAGGCT ATGAGCTTCA GGAAGACAGG 
CATTCCTGCC AGGCTGAGTG CAGCAGCGAG CTGTACACGG AGGCATCAGG CTACATCTCC 
AGCCTGGAGT ACCCTCGGTC CTACCCCCCT GACCTGCGCT GCAACTACAG CATCCGGGTG 
GAGCGGGGCC TCACCCTGCA CCTCAAGTTC CTGGAGCCTT TTGATATTGA TGACCACCAG 
CAAGTACACT GCCCCTATGA CCAGCTACAG ATCTATGCCA ACGGGAAGAA CATTGGCGAG 
TTCTGTGGGA AGCAAAGGCC CCCCGACCTC GACACCAGCA GCAATGCTGT GGATCTGCTG 
TTCTTCACAG ATGAGTCGGG GGACAGCCGG GGCTGGAAGC TGCGCTACAC CACCGAGATC 
ATCAAGTGCC CCCAGCCCAA GACCCTAGAC GAGTTCACCA TCATCCAGAA CCTGCAGCCT 
CAGTACCAGT TCCGTGACTA CTTCATTGCT ACCTGCAAGC AAGGCTACCA GCTCATAGAG 
GGGAACCAGG TGCTGCATTC CTTCACAGCT GTCTGCCAGG ATGATGGCAC GTGGCATCGT 
GCCATGCCCA GATGCAAGAT CAAGGACTGT GGGCAGCCCC GAAACCTGCC TAATGGTGAC 
TTCCGTTACA CCACCACAAT GGGAGTGAAC ACCTACAAGG CCCGTATCCA GTACTACTGC 
CATGAGCCAT ATTACAAGAT GCAGACCAGA GCTGGCAGCA GGGAGTCTGA GCAAGGGGTG 
TACACCTGCA CAGCACAGGG CATTTGGAAG AATGAACAGA AGGGAGAGAA GATTCCTCGG 
TGCTTGCCAG TGTGTGGGAA GCCCGTGAAC CCCGTGGAAC AGAGGCAGCG CATCATCGGA 
GGGCAAAAAG CCAAGATGGG CAACTTCCCC TGGCAGGTGT TCACCAACAT CCACGGGCGC 
GGGGGCGGGG CCCTGCTGGG CGACCGCTGG ATCCTCACAG CTGCCCACAC CCTGTATCCC 
AAGGAACACG AAGCGCAAAG CAACGCCTCT TTGGATGTGT TCCTGGGCCA CACAAATGTG 
GAAGAGCTCA TGAAGCTAGG AAATCACCCC ATCCGCAGGG TCAGCGTCCA CCCGGACTAC 
CGTCAGGATG AGTCCTACAA TTTTGAGGGG GACATCGCCC TGCTGGAGCT GGAAAATAGT 
GTCACCCTGG GTCCCAACCT CCTCCCCATC TGCCTCCCTG ACAACGATAC CTTCTACGAC 
CTGGGCTTGA TGGGCTATGT CAGTGGCTTC GGGGTCATGG AGGAGAAGAT TGCTCATGAC 
CTCAGGTTTG TCCGTCTGCC CGTAGCTAAT CCACAGGCCT GTGAGAACTG GCTCCGGGGA 
AAGAATAGGA TGGATGTGTT CTCTCAAAAC ATGTTCTGTG CTGGACACCC ATCTCTAAAG 
CAGGACGCCT GCCAGGGGGA TAGTGGGGGC GTTTTTGCAG TAAGGGACCC GAACACTGAT 
CGCTGGGTGG CCACGGGCAT CGTGTCCTGG GGCATCGGGT GCAGCAGGGG CTATGGCTTC 
TACACCAAAG TGCTCAACTA CGTGGACTGG ATCAAGAAAG AGATGGAGGA GGAGGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Brief Report: Deficiency of Complement 1r Subcomponent in Early-Onset Systemic Lupus Erythematosus: The Role of Disease-Modifying Alleles in a Monogenic Disease.
Arthritis & rheumatology (Hoboken, N.J.)69(9)1832-1839(2017 09)
Demirkaya E,Zhou Q,Smith CK,Ombrello MJ,Deuitch N,Tsai WL,Hoffmann P,Remmers EF,Takeuchi M,Park YH,Chae J,Barut K,Simsek D,Adrovic A,Sahin S,Caliskan S,Chandrasekharappa SC,Hasni SA,Ombrello AK,Gadina M,Kastner DL,Kaplan MJ,Kasapcopur O,Aksentijevich I

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Structure and activation of C1, the complex initiating the classical pathway of the complement cascade.
Proceedings of the National Academy of Sciences of the United States of America114(5)986-991(2017 Jan)
Mortensen SA,Sander B,Jensen RK,Pedersen JS,Golas MM,Jensenius JC,Hansen AG,Thiel S,Andersen GR

Periodontal Ehlers-Danlos Syndrome Is Caused by Mutations in C1R and C1S, which Encode Subcomponents C1r and C1s of Complement.
American journal of human genetics99(5)1005-1014(2016 Nov)
Kapferer-Seebacher I,Pepin M,Werner R,Aitman TJ,Nordgren A,Stoiber H,Thielens N,Gaboriaud C,Amberger A,Schossig A,Gruber R,Giunta C,Bamshad M,Bj?rck E,Chen C,Chitayat D,Dorschner M,Schmitt-Egenolf M,Hale CJ,Hanna D,Hennies HC,Heiss-Kisielewsky I,Lindstrand A,Lundberg P,Mitchell AL,Nickerson DA,Reinstein E,Rohrbach M,Romani N,Schmuth M,Silver R,Taylan F,Vandersteen A,Vandrovcova J,Weerakkody R,Yang M,Pope FM,,Byers PH,Zschocke J

Proteomic analysis for the identification of serum diagnostic markers for joint hypermobility syndrome.
International journal of molecular medicine37(2)461-7(2016 Feb)
Watanabe A,Satoh K,Maniwa T,Matsumoto K

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C1R cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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