TNNI2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TNNI2
Entrez Gene ID	7136
Full Name	troponin I2, fast skeletal type
Synonyms	AMCD2B,DA2B,FSSV,fsTnI
General protein information	Preferred Names troponin I2, fast skeletal type Names troponin I, fast skeletal muscle troponin I fast twitch 2 troponin I type 2 (skeletal, fast) troponin I, fast-twitch isoform troponin I, fast-twitch skeletal muscle isoform troponin I, skeletal, fast
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11p15.5
Summary	This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009].
Disorder MIM:	191043
Disorder Html:	Arthrogryposis multiplex congenita, distal, type 2B, 601680 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001145829.1	NP_001139301.1	troponin I, fast skeletal muscle isoform 1
NM_003282.3	NP_003273.1	troponin I, fast skeletal muscle isoform 1
NM_001145841.1	NP_001139313.1	troponin I, fast skeletal muscle isoform 2
NM_001145841.2	NP_001139313.1	troponin I, fast skeletal muscle isoform 2
NM_003282.4	NP_003273.1	troponin I, fast skeletal muscle isoform 1
NM_001145829.2	NP_001139301.1	troponin I, fast skeletal muscle isoform 1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Tnni2	NP_033431.1
Rattus norvegicus (Norway rat)	Tnni2	NP_058881.1
Danio rerio (zebrafish)	tnni2a.1	NP_001007366.1
Danio rerio (zebrafish)	tnni2a.4	NP_001009901.2
Pan troglodytes (chimpanzee)	TNNI2	XP_001153267.1
Bos taurus (cattle)	TNNI2	NP_001179023.1
Xenopus tropicalis (tropical clawed frog)	tnni2	NP_001011110.1
	LOC721041	XP_001117040.1
Canis lupus familiaris (dog)	TNNI2	XP_851068.1
Danio rerio (zebrafish)	tnni2a.3	NP_991138.2
Danio rerio (zebrafish)	tnni2b.1	NP_001129964.1
Danio rerio (zebrafish)	tnni2a.2	NP_957387.1
Homo sapiens (human)	TNNI2	NP_001139301.1
Gallus gallus (chicken)	TNNI2	NP_990748.1
Danio rerio (zebrafish)	tnni2b.2	NP_001003423.1

Gene Ontology
Bibliography

Related articles in PubMed

Genotype-specific pathogenic effects in human dilated cardiomyopathy.
Bollen IAE, Schuldt M, Harakalova M, Vink A, Asselbergs FW, Pinto JR, Kr?ger M, Kuster DWD, van der Velden J
The Journal of physiology595(14)4677-4693(2017 Jul)

A novel missense mutation of TNNI2 in a Chinese family cause distal arthrogryposis type 1.
Wang B, Zheng Z, Wang Z, Zhang X, Yang H, Cai H, Fu Q
American journal of medical genetics. Part A170A(1)135-41(2016 Jan)

A novel TNNI2 mutation causes Freeman-Sheldon syndrome in a Chinese family with an affected adult with only facial contractures.
Li X, Jiang M, Han W, Zhao N, Liu W, Sui Y, Lu Y, Li J
Gene527(2)630-5(2013 Sep)

A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease.
?stensson M, Mont?n C, Bacelis J, Gudjonsdottir AH, Adamovic S, Ek J, Ascher H, Pollak E, Arnell H, Browaldh L, Agardh D, Wahlstr?m J, Nilsson S, Torinsson-Naluai ?
PloS one8(8)e70174(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TNNI2 gene missense mutation is associated with distal arthrogryposis type 1.
Title: A novel missense mutation of TNNI2 in a Chinese family cause distal arthrogryposis type 1.

report the first TNNI2 mutation in classical FSS and describe an atypical adult FSS case with only facial contractures resulting from somatic mosaicism
Title: A novel TNNI2 mutation causes Freeman-Sheldon syndrome in a Chinese family with an affected adult with only facial contractures.

Molecular genetic investigations revealed pathogenic mutations in MYH3, TPM2, and TNNI2 in one sporadic and 19 familial cases of distal arthrogryposis.
Title: Distal arthrogryposis: clinical and genetic findings.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

The following TNNI2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TNNI2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu28264	NM_001145829.2 Latest version!	Homo sapiens troponin I2, fast skeletal type (TNNI2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu28264	NM_003282.4 Latest version!	Homo sapiens troponin I2, fast skeletal type (TNNI2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu28294	NM_001145841.2 Latest version!	Homo sapiens troponin I2, fast skeletal type (TNNI2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu28294	NM_001145841.1	Homo sapiens troponin I2, fast skeletal type (TNNI2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu28264	NM_003282.3	Homo sapiens troponin I2, fast skeletal type (TNNI2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu28264	NM_001145829.1	Homo sapiens troponin I2, fast skeletal type (TNNI2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TNNI2 ( NM_001145829.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001139301.1 Homo sapiens troponin I2, fast skeletal type (TNNI2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu28264
Clone ID Related Accession (Same CDS sequence)	NM_001145829.1 , NM_003282.3 , NM_003282.4 , NM_001145829.2
Accession Version	NM_001145829.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 549bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-28
Organism	Homo sapiens(human)
Product	troponin I, fast skeletal muscle isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC051649.21, BC032148.2 and AW984315.1. On Jun 1, 2019 this sequence version replaced NM_001145829.1. Transcript Variant: This variant (2) has an alternate 5' UTR exon, and encodes the same isoform 1, as compared to variant 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC032148.2, AL546648.3 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA2144335 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGAGATG AGGAGAAGCG GAACAGGGCC ATCACGGCCC GCAGGCAGCA CCTGAAGAGT 
GTGATGCTGC AGATAGCGGC CACGGAGCTG GAGAAGGAGG AGAGCCGCCG TGAGGCAGAG 
AAGCAGAACT ACCTGGCGGA GCACTGCCCG CCGCTGCATA TCCCGGGCTC CATGTCTGAA 
GTGCAGGAGC TCTGCAAACA GCTGCACGCC AAGATCGATG CGGCTGAAGA GGAGAAGTAC 
GACATGGAGG TGAGGGTGCA GAAGACCAGC AAGGAGCTGG AGGACATGAA CCAGAAGCTA 
TTTGATCTGC GGGGCAAGTT CAAGCGGCCC CCACTGCGGA GGGTGCGCAT GTCGGCCGAT 
GCCATGCTCA AGGCCCTGCT GGGCTCGAAG CACAAGGTGT GCATGGACCT GAGGGCCAAC 
CTGAAGCAGG TCAAGAAGGA GGACACAGAG AAGGAGCGGG ACCTGCGAGA CGTGGGTGAC 
TGGAGGAAGA ACATCGAGGA GAAGTCTGGC ATGGAGGGCC GGAAGAAGAT GTTTGAGTCC 
GAGTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001139301.1
CDS	82..630
Translation	MGDEEKRNRAITARRQHLKSVMLQIAATELEKEESRREAEKQNYLAEHCPPLHIPGSMSEVQELCKQLHAKIDAAEEEKYDMEVRVQKTSKELEDMNQKLFDLRGKFKRPPLRRVRMSADAMLKALLGSKHKVCMDLRANLKQVKKEDTEKERDLRDVGDWRKNIEEKSGMEGRKKMFESES

Target ORF information:

RefSeq Version	NM_001145829.2
Organism	Homo sapiens(human)
Definition	Homo sapiens troponin I2, fast skeletal type (TNNI2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001145829.2

ORF Insert Sequence:

ATGGGAGATG AGGAGAAGCG GAACAGGGCC ATCACGGCCC GCAGGCAGCA CCTGAAGAGT 
GTGATGCTGC AGATAGCGGC CACGGAGCTG GAGAAGGAGG AGAGCCGCCG TGAGGCAGAG 
AAGCAGAACT ACCTGGCGGA GCACTGCCCG CCGCTGCATA TCCCGGGCTC CATGTCTGAA 
GTGCAGGAGC TCTGCAAACA GCTGCACGCC AAGATCGATG CGGCTGAAGA GGAGAAGTAC 
GACATGGAGG TGAGGGTGCA GAAGACCAGC AAGGAGCTGG AGGACATGAA CCAGAAGCTA 
TTTGATCTGC GGGGCAAGTT CAAGCGGCCC CCACTGCGGA GGGTGCGCAT GTCGGCCGAT 
GCCATGCTCA AGGCCCTGCT GGGCTCGAAG CACAAGGTGT GCATGGACCT GAGGGCCAAC 
CTGAAGCAGG TCAAGAAGGA GGACACAGAG AAGGAGCGGG ACCTGCGAGA CGTGGGTGAC 
TGGAGGAAGA ACATCGAGGA GAAGTCTGGC ATGGAGGGCC GGAAGAAGAT GTTTGAGTCC 
GAGTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TNNI2 ( NM_001145829.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001139301.1 Homo sapiens troponin I2, fast skeletal type (TNNI2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu28264
Clone ID Related Accession (Same CDS sequence)	NM_001145829.1 , NM_003282.3 , NM_003282.4 , NM_001145829.2
Accession Version	NM_001145829.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 549bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-20
Organism	Homo sapiens(human)
Product	troponin I, fast skeletal muscle isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC032148.2, AW984315.1 and F36243.1. Transcript Variant: This variant (2) has an alternate 5' UTR exon, and encodes the same isoform 1, as compared to variant 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC032148.2, ERR279836.2322.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA2144335 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGAGATG AGGAGAAGCG GAACAGGGCC ATCACGGCCC GCAGGCAGCA CCTGAAGAGT 
GTGATGCTGC AGATAGCGGC CACGGAGCTG GAGAAGGAGG AGAGCCGCCG TGAGGCAGAG 
AAGCAGAACT ACCTGGCGGA GCACTGCCCG CCGCTGCATA TCCCGGGCTC CATGTCTGAA 
GTGCAGGAGC TCTGCAAACA GCTGCACGCC AAGATCGATG CGGCTGAAGA GGAGAAGTAC 
GACATGGAGG TGAGGGTGCA GAAGACCAGC AAGGAGCTGG AGGACATGAA CCAGAAGCTA 
TTTGATCTGC GGGGCAAGTT CAAGCGGCCC CCACTGCGGA GGGTGCGCAT GTCGGCCGAT 
GCCATGCTCA AGGCCCTGCT GGGCTCGAAG CACAAGGTGT GCATGGACCT GAGGGCCAAC 
CTGAAGCAGG TCAAGAAGGA GGACACAGAG AAGGAGCGGG ACCTGCGAGA CGTGGGTGAC 
TGGAGGAAGA ACATCGAGGA GAAGTCTGGC ATGGAGGGCC GGAAGAAGAT GTTTGAGTCC 
GAGTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001139301.1
CDS	62..610
Translation	MGDEEKRNRAITARRQHLKSVMLQIAATELEKEESRREAEKQNYLAEHCPPLHIPGSMSEVQELCKQLHAKIDAAEEEKYDMEVRVQKTSKELEDMNQKLFDLRGKFKRPPLRRVRMSADAMLKALLGSKHKVCMDLRANLKQVKKEDTEKERDLRDVGDWRKNIEEKSGMEGRKKMFESES

Target ORF information:

RefSeq Version	NM_001145829.1
Organism	Homo sapiens(human)
Definition	Homo sapiens troponin I2, fast skeletal type (TNNI2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001145829.1

ORF Insert Sequence:

ATGGGAGATG AGGAGAAGCG GAACAGGGCC ATCACGGCCC GCAGGCAGCA CCTGAAGAGT 
GTGATGCTGC AGATAGCGGC CACGGAGCTG GAGAAGGAGG AGAGCCGCCG TGAGGCAGAG 
AAGCAGAACT ACCTGGCGGA GCACTGCCCG CCGCTGCATA TCCCGGGCTC CATGTCTGAA 
GTGCAGGAGC TCTGCAAACA GCTGCACGCC AAGATCGATG CGGCTGAAGA GGAGAAGTAC 
GACATGGAGG TGAGGGTGCA GAAGACCAGC AAGGAGCTGG AGGACATGAA CCAGAAGCTA 
TTTGATCTGC GGGGCAAGTT CAAGCGGCCC CCACTGCGGA GGGTGCGCAT GTCGGCCGAT 
GCCATGCTCA AGGCCCTGCT GGGCTCGAAG CACAAGGTGT GCATGGACCT GAGGGCCAAC 
CTGAAGCAGG TCAAGAAGGA GGACACAGAG AAGGAGCGGG ACCTGCGAGA CGTGGGTGAC 
TGGAGGAAGA ACATCGAGGA GAAGTCTGGC ATGGAGGGCC GGAAGAAGAT GTTTGAGTCC 
GAGTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TNNI2 ( NM_003282.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003273.1 Homo sapiens troponin I2, fast skeletal type (TNNI2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu28264
Clone ID Related Accession (Same CDS sequence)	NM_001145829.1 , NM_003282.3 , NM_003282.4 , NM_001145829.2
Accession Version	NM_003282.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 549bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	troponin I, fast skeletal muscle isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP233165.1, L21715.1, AW984315.1 and F36243.1. This sequence is a reference standard in the RefSeqGene project. On Mar 13, 2009 this sequence version replaced NM_003282.2. Transcript Variant: This variant (1) and variant 2 encode the same protein (isoform 1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279847.7393.1, ERR279837.144.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGGAGATG AGGAGAAGCG GAACAGGGCC ATCACGGCCC GCAGGCAGCA CCTGAAGAGT 
GTGATGCTGC AGATAGCGGC CACGGAGCTG GAGAAGGAGG AGAGCCGCCG TGAGGCAGAG 
AAGCAGAACT ACCTGGCGGA GCACTGCCCG CCGCTGCATA TCCCGGGCTC CATGTCTGAA 
GTGCAGGAGC TCTGCAAACA GCTGCACGCC AAGATCGATG CGGCTGAAGA GGAGAAGTAC 
GACATGGAGG TGAGGGTGCA GAAGACCAGC AAGGAGCTGG AGGACATGAA CCAGAAGCTA 
TTTGATCTGC GGGGCAAGTT CAAGCGGCCC CCACTGCGGA GGGTGCGCAT GTCGGCCGAT 
GCCATGCTCA AGGCCCTGCT GGGCTCGAAG CACAAGGTGT GCATGGACCT GAGGGCCAAC 
CTGAAGCAGG TCAAGAAGGA GGACACAGAG AAGGAGCGGG ACCTGCGAGA CGTGGGTGAC 
TGGAGGAAGA ACATCGAGGA GAAGTCTGGC ATGGAGGGCC GGAAGAAGAT GTTTGAGTCC 
GAGTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003273.1
CDS	54..602
Translation	MGDEEKRNRAITARRQHLKSVMLQIAATELEKEESRREAEKQNYLAEHCPPLHIPGSMSEVQELCKQLHAKIDAAEEEKYDMEVRVQKTSKELEDMNQKLFDLRGKFKRPPLRRVRMSADAMLKALLGSKHKVCMDLRANLKQVKKEDTEKERDLRDVGDWRKNIEEKSGMEGRKKMFESES

Target ORF information:

RefSeq Version	NM_003282.3
Organism	Homo sapiens(human)
Definition	Homo sapiens troponin I2, fast skeletal type (TNNI2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003282.3

ORF Insert Sequence:

ATGGGAGATG AGGAGAAGCG GAACAGGGCC ATCACGGCCC GCAGGCAGCA CCTGAAGAGT 
GTGATGCTGC AGATAGCGGC CACGGAGCTG GAGAAGGAGG AGAGCCGCCG TGAGGCAGAG 
AAGCAGAACT ACCTGGCGGA GCACTGCCCG CCGCTGCATA TCCCGGGCTC CATGTCTGAA 
GTGCAGGAGC TCTGCAAACA GCTGCACGCC AAGATCGATG CGGCTGAAGA GGAGAAGTAC 
GACATGGAGG TGAGGGTGCA GAAGACCAGC AAGGAGCTGG AGGACATGAA CCAGAAGCTA 
TTTGATCTGC GGGGCAAGTT CAAGCGGCCC CCACTGCGGA GGGTGCGCAT GTCGGCCGAT 
GCCATGCTCA AGGCCCTGCT GGGCTCGAAG CACAAGGTGT GCATGGACCT GAGGGCCAAC 
CTGAAGCAGG TCAAGAAGGA GGACACAGAG AAGGAGCGGG ACCTGCGAGA CGTGGGTGAC 
TGGAGGAAGA ACATCGAGGA GAAGTCTGGC ATGGAGGGCC GGAAGAAGAT GTTTGAGTCC 
GAGTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TNNI2 ( NM_003282.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003273.1 Homo sapiens troponin I2, fast skeletal type (TNNI2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu28264
Clone ID Related Accession (Same CDS sequence)	NM_001145829.1 , NM_003282.3 , NM_003282.4 , NM_001145829.2
Accession Version	NM_003282.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 549bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	troponin I, fast skeletal muscle isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC051649.21, BP233165.1, L21715.1, AW984315.1 and F36243.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_003282.3. Transcript Variant: This variant (1) and variant 2 encode the same protein (isoform 1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279874.511.1, ERR279867.1122.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000381911.6/ ENSP00000371336.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGAGATG AGGAGAAGCG GAACAGGGCC ATCACGGCCC GCAGGCAGCA CCTGAAGAGT 
GTGATGCTGC AGATAGCGGC CACGGAGCTG GAGAAGGAGG AGAGCCGCCG TGAGGCAGAG 
AAGCAGAACT ACCTGGCGGA GCACTGCCCG CCGCTGCATA TCCCGGGCTC CATGTCTGAA 
GTGCAGGAGC TCTGCAAACA GCTGCACGCC AAGATCGATG CGGCTGAAGA GGAGAAGTAC 
GACATGGAGG TGAGGGTGCA GAAGACCAGC AAGGAGCTGG AGGACATGAA CCAGAAGCTA 
TTTGATCTGC GGGGCAAGTT CAAGCGGCCC CCACTGCGGA GGGTGCGCAT GTCGGCCGAT 
GCCATGCTCA AGGCCCTGCT GGGCTCGAAG CACAAGGTGT GCATGGACCT GAGGGCCAAC 
CTGAAGCAGG TCAAGAAGGA GGACACAGAG AAGGAGCGGG ACCTGCGAGA CGTGGGTGAC 
TGGAGGAAGA ACATCGAGGA GAAGTCTGGC ATGGAGGGCC GGAAGAAGAT GTTTGAGTCC 
GAGTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003273.1
CDS	76..624
Translation	MGDEEKRNRAITARRQHLKSVMLQIAATELEKEESRREAEKQNYLAEHCPPLHIPGSMSEVQELCKQLHAKIDAAEEEKYDMEVRVQKTSKELEDMNQKLFDLRGKFKRPPLRRVRMSADAMLKALLGSKHKVCMDLRANLKQVKKEDTEKERDLRDVGDWRKNIEEKSGMEGRKKMFESES

Target ORF information:

RefSeq Version	NM_003282.4
Organism	Homo sapiens(human)
Definition	Homo sapiens troponin I2, fast skeletal type (TNNI2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003282.4

ORF Insert Sequence:

ATGGGAGATG AGGAGAAGCG GAACAGGGCC ATCACGGCCC GCAGGCAGCA CCTGAAGAGT 
GTGATGCTGC AGATAGCGGC CACGGAGCTG GAGAAGGAGG AGAGCCGCCG TGAGGCAGAG 
AAGCAGAACT ACCTGGCGGA GCACTGCCCG CCGCTGCATA TCCCGGGCTC CATGTCTGAA 
GTGCAGGAGC TCTGCAAACA GCTGCACGCC AAGATCGATG CGGCTGAAGA GGAGAAGTAC 
GACATGGAGG TGAGGGTGCA GAAGACCAGC AAGGAGCTGG AGGACATGAA CCAGAAGCTA 
TTTGATCTGC GGGGCAAGTT CAAGCGGCCC CCACTGCGGA GGGTGCGCAT GTCGGCCGAT 
GCCATGCTCA AGGCCCTGCT GGGCTCGAAG CACAAGGTGT GCATGGACCT GAGGGCCAAC 
CTGAAGCAGG TCAAGAAGGA GGACACAGAG AAGGAGCGGG ACCTGCGAGA CGTGGGTGAC 
TGGAGGAAGA ACATCGAGGA GAAGTCTGGC ATGGAGGGCC GGAAGAAGAT GTTTGAGTCC 
GAGTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TNNI2 ( NM_001145841.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001139313.1 Homo sapiens troponin I2, fast skeletal type (TNNI2), transcript variant 3, mRNA.

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CloneID	OHu28294
Clone ID Related Accession (Same CDS sequence)	NM_001145841.1 , NM_001145841.2
Accession Version	NM_001145841.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 549bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-20
Organism	Homo sapiens(human)
Product	troponin I, fast skeletal muscle isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI833431.1, AW984315.1 and F36243.1. Transcript Variant: This variant (3) lacks a few of 5' exons, but has an alternate 5' exon, as compared to variant 1. The resulting isoform (2) is the same size but has a different N-terminus, as compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BI833431.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCCAGT GCAAGAAGCG GAACAGGGCC ATCACGGCCC GCAGGCAGCA CCTGAAGAGT 
GTGATGCTGC AGATAGCGGC CACGGAGCTG GAGAAGGAGG AGAGCCGCCG TGAGGCAGAG 
AAGCAGAACT ACCTGGCGGA GCACTGCCCG CCGCTGCATA TCCCGGGCTC CATGTCTGAA 
GTGCAGGAGC TCTGCAAACA GCTGCACGCC AAGATCGATG CGGCTGAAGA GGAGAAGTAC 
GACATGGAGG TGAGGGTGCA GAAGACCAGC AAGGAGCTGG AGGACATGAA CCAGAAGCTA 
TTTGATCTGC GGGGCAAGTT CAAGCGGCCC CCACTGCGGA GGGTGCGCAT GTCGGCCGAT 
GCCATGCTCA AGGCCCTGCT GGGCTCGAAG CACAAGGTGT GCATGGACCT GAGGGCCAAC 
CTGAAGCAGG TCAAGAAGGA GGACACAGAG AAGGAGCGGG ACCTGCGAGA CGTGGGTGAC 
TGGAGGAAGA ACATCGAGGA GAAGTCTGGC ATGGAGGGCC GGAAGAAGAT GTTTGAGTCC 
GAGTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001139313.1
CDS	23..571
Translation	MSQCKKRNRAITARRQHLKSVMLQIAATELEKEESRREAEKQNYLAEHCPPLHIPGSMSEVQELCKQLHAKIDAAEEEKYDMEVRVQKTSKELEDMNQKLFDLRGKFKRPPLRRVRMSADAMLKALLGSKHKVCMDLRANLKQVKKEDTEKERDLRDVGDWRKNIEEKSGMEGRKKMFESES

Target ORF information:

RefSeq Version	NM_001145841.1
Organism	Homo sapiens(human)
Definition	Homo sapiens troponin I2, fast skeletal type (TNNI2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001145841.1

ORF Insert Sequence:

ATGTCCCAGT GCAAGAAGCG GAACAGGGCC ATCACGGCCC GCAGGCAGCA CCTGAAGAGT 
GTGATGCTGC AGATAGCGGC CACGGAGCTG GAGAAGGAGG AGAGCCGCCG TGAGGCAGAG 
AAGCAGAACT ACCTGGCGGA GCACTGCCCG CCGCTGCATA TCCCGGGCTC CATGTCTGAA 
GTGCAGGAGC TCTGCAAACA GCTGCACGCC AAGATCGATG CGGCTGAAGA GGAGAAGTAC 
GACATGGAGG TGAGGGTGCA GAAGACCAGC AAGGAGCTGG AGGACATGAA CCAGAAGCTA 
TTTGATCTGC GGGGCAAGTT CAAGCGGCCC CCACTGCGGA GGGTGCGCAT GTCGGCCGAT 
GCCATGCTCA AGGCCCTGCT GGGCTCGAAG CACAAGGTGT GCATGGACCT GAGGGCCAAC 
CTGAAGCAGG TCAAGAAGGA GGACACAGAG AAGGAGCGGG ACCTGCGAGA CGTGGGTGAC 
TGGAGGAAGA ACATCGAGGA GAAGTCTGGC ATGGAGGGCC GGAAGAAGAT GTTTGAGTCC 
GAGTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TNNI2 ( NM_001145841.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001139313.1 Homo sapiens troponin I2, fast skeletal type (TNNI2), transcript variant 3, mRNA.

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CloneID	OHu28294
Clone ID Related Accession (Same CDS sequence)	NM_001145841.1 , NM_001145841.2
Accession Version	NM_001145841.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 549bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	troponin I, fast skeletal muscle isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI833431.1, AW984315.1 and F36243.1. On May 31, 2019 this sequence version replaced NM_001145841.1. Transcript Variant: This variant (3) lacks a few of 5' exons, but has an alternate 5' exon, as compared to variant 1. The resulting isoform (2) is the same size but has a different N-terminus, as compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BI833431.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCCAGT GCAAGAAGCG GAACAGGGCC ATCACGGCCC GCAGGCAGCA CCTGAAGAGT 
GTGATGCTGC AGATAGCGGC CACGGAGCTG GAGAAGGAGG AGAGCCGCCG TGAGGCAGAG 
AAGCAGAACT ACCTGGCGGA GCACTGCCCG CCGCTGCATA TCCCGGGCTC CATGTCTGAA 
GTGCAGGAGC TCTGCAAACA GCTGCACGCC AAGATCGATG CGGCTGAAGA GGAGAAGTAC 
GACATGGAGG TGAGGGTGCA GAAGACCAGC AAGGAGCTGG AGGACATGAA CCAGAAGCTA 
TTTGATCTGC GGGGCAAGTT CAAGCGGCCC CCACTGCGGA GGGTGCGCAT GTCGGCCGAT 
GCCATGCTCA AGGCCCTGCT GGGCTCGAAG CACAAGGTGT GCATGGACCT GAGGGCCAAC 
CTGAAGCAGG TCAAGAAGGA GGACACAGAG AAGGAGCGGG ACCTGCGAGA CGTGGGTGAC 
TGGAGGAAGA ACATCGAGGA GAAGTCTGGC ATGGAGGGCC GGAAGAAGAT GTTTGAGTCC 
GAGTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001139313.1
CDS	18..566
Translation	MSQCKKRNRAITARRQHLKSVMLQIAATELEKEESRREAEKQNYLAEHCPPLHIPGSMSEVQELCKQLHAKIDAAEEEKYDMEVRVQKTSKELEDMNQKLFDLRGKFKRPPLRRVRMSADAMLKALLGSKHKVCMDLRANLKQVKKEDTEKERDLRDVGDWRKNIEEKSGMEGRKKMFESES

Target ORF information:

RefSeq Version	NM_001145841.2
Organism	Homo sapiens(human)
Definition	Homo sapiens troponin I2, fast skeletal type (TNNI2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001145841.2

ORF Insert Sequence:

ATGTCCCAGT GCAAGAAGCG GAACAGGGCC ATCACGGCCC GCAGGCAGCA CCTGAAGAGT 
GTGATGCTGC AGATAGCGGC CACGGAGCTG GAGAAGGAGG AGAGCCGCCG TGAGGCAGAG 
AAGCAGAACT ACCTGGCGGA GCACTGCCCG CCGCTGCATA TCCCGGGCTC CATGTCTGAA 
GTGCAGGAGC TCTGCAAACA GCTGCACGCC AAGATCGATG CGGCTGAAGA GGAGAAGTAC 
GACATGGAGG TGAGGGTGCA GAAGACCAGC AAGGAGCTGG AGGACATGAA CCAGAAGCTA 
TTTGATCTGC GGGGCAAGTT CAAGCGGCCC CCACTGCGGA GGGTGCGCAT GTCGGCCGAT 
GCCATGCTCA AGGCCCTGCT GGGCTCGAAG CACAAGGTGT GCATGGACCT GAGGGCCAAC 
CTGAAGCAGG TCAAGAAGGA GGACACAGAG AAGGAGCGGG ACCTGCGAGA CGTGGGTGAC 
TGGAGGAAGA ACATCGAGGA GAAGTCTGGC ATGGAGGGCC GGAAGAAGAT GTTTGAGTCC 
GAGTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genotype-specific pathogenic effects in human dilated cardiomyopathy.
The Journal of physiology595(14)4677-4693(2017 Jul)
Bollen IAE,Schuldt M,Harakalova M,Vink A,Asselbergs FW,Pinto JR,Kr?ger M,Kuster DWD,van der Velden J

A novel missense mutation of TNNI2 in a Chinese family cause distal arthrogryposis type 1.
American journal of medical genetics. Part A170A(1)135-41(2016 Jan)
Wang B,Zheng Z,Wang Z,Zhang X,Yang H,Cai H,Fu Q

A novel TNNI2 mutation causes Freeman-Sheldon syndrome in a Chinese family with an affected adult with only facial contractures.
Gene527(2)630-5(2013 Sep)
Li X,Jiang M,Han W,Zhao N,Liu W,Sui Y,Lu Y,Li J

A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease.
PloS one8(8)e70174(2013)
?stensson M,Mont?n C,Bacelis J,Gudjonsdottir AH,Adamovic S,Ek J,Ascher H,Pollak E,Arnell H,Browaldh L,Agardh D,Wahlstr?m J,Nilsson S,Torinsson-Naluai ?

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TNNI2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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