TNFAIP6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TNFAIP6
Entrez Gene ID	7130
Full Name	TNF alpha induced protein 6
Synonyms	TSG-6,TSG6
General protein information	Preferred Names TNF alpha induced protein 6 Names tumor necrosis factor-inducible gene 6 protein TNF-stimulated gene 6 protein hyaluronate-binding protein tumor necrosis factor alpha-inducible protein 6 tumor necrosis factor, alpha induced protein 6 tumor necrosis factor-stimulated gene-6 protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q23.3
Summary	The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis.[provided by RefSeq, Dec 2010].
Disorder MIM:	600410

mRNA and Protein(s)

mRNA	Protein	Name
NM_007115.4	NP_009046.2	tumor necrosis factor-inducible gene 6 protein precursor
NM_007115.3	NP_009046.2	tumor necrosis factor-inducible gene 6 protein precursor

Pathways from BioSystems

Homologies

	TNFAIP6	XP_001083111.1
Homo sapiens (human)	TNFAIP6	NP_009046.2
Bos taurus (cattle)	TNFAIP6	NP_001007814.1
Mus musculus (house mouse)	Tnfaip6	NP_033424.1
Rattus norvegicus (Norway rat)	Tnfaip6	NP_445834.1
Canis lupus familiaris (dog)	TNFAIP6	XP_533354.3
Gallus gallus (chicken)	TNFAIP6	NP_001032926.2
Xenopus tropicalis (tropical clawed frog)	tnfaip6	XP_002936705.1
Pan troglodytes (chimpanzee)	TNFAIP6	XP_516218.2
Danio rerio (zebrafish)	tnfaip6	NP_001035333.2

Gene Ontology
Bibliography

Related articles in PubMed

TSG-6 is highly expressed in human abdominal aortic aneurysms.
Wang SK, Xie J, Green LA, McCready RA, Motaganahalli RL, Fajardo A, Babbey CC, Murphy MP
The Journal of surgical research220311-319(2017 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

abnormally elevated in both the plasma and aortic wall of patients with abdominal aortic aneurysms
Title: TSG-6 is highly expressed in human abdominal aortic aneurysms.

Single nucleotide polymorphism in TNFAIP6 gene is associated with Systemic lupus erythematosus.
Title: Novel linkage disequilibrium clustering algorithm identifies new lupus genes on meta-analysis of GWAS datasets.

TNFAIP6 expression is significantly upregulated in human masticatory mucosa during wound healing
Title: Human gingiva transcriptome during wound healing.

Data show that TNF-stimulated gene-6 (TSG-6) interacts with chemokines through their glycosaminoglycans (GAGs)-binding sites and inhibits their binding to GAGs and endothelial cell surfaces.
Title: The Anti-inflammatory Protein TSG-6 Regulates Chemokine Function by Inhibiting Chemokine/Glycosaminoglycan Interactions.

The current study describes a novel mechanism linking the TSG-6 transfer of the newly described HC5 to the HA-dependent control of cell phenotype. The interaction of HC5 with cell surface HA was essential for TGFbeta1-dependent differentiation of fibroblasts to myofibroblasts, highlighting its importance as a novel potential therapeutic target.
Title: Tumor Necrosis Factor-stimulated Gene 6 (TSG-6)-mediated Interactions with the Inter-?-inhibitor Heavy Chain 5 Facilitate Tumor Growth Factor ?1 (TGF?1)-dependent Fibroblast to Myofibroblast Differentiation.

The following TNFAIP6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TNFAIP6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu23157	NM_007115.4 Latest version!	Homo sapiens TNF alpha induced protein 6 (TNFAIP6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
View Old Accession Versions >>
OHu23157	NM_007115.3	Homo sapiens TNF alpha induced protein 6 (TNFAIP6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TNFAIP6 ( NM_007115.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_009046.2 Homo sapiens TNF alpha induced protein 6 (TNFAIP6), mRNA.

Price & Availability↑

CloneID	OHu23157
Clone ID Related Accession (Same CDS sequence)	NM_007115.4 , NM_007115.3
Accession Version	NM_007115.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 834bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-15
Organism	Homo sapiens(human)
Product	tumor necrosis factor-inducible gene 6 protein precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AU102580.1, BC030205.1 and AC009311.3. On Nov 23, 2018 this sequence version replaced NM_007115.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189655.73644.1, SRR5189652.124369.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000243347.5/ ENSP00000243347.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGATCATCT TAATTTACTT ATTTCTCTTG CTATGGGAAG ACACTCAAGG ATGGGGATTC 
AAGGATGGAA TTTTTCATAA CTCCATATGG CTTGAACGAG CAGCCGGTGT GTACCACAGA 
GAAGCACGGT CTGGCAAATA CAAGCTCACC TACGCAGAAG CTAAGGCGGT GTGTGAATTT 
GAAGGCGGCC ATCTCGCAAC TTACAAGCAG CTAGAGGCAG CCAGAAAAAT TGGATTTCAT 
GTCTGTGCTG CTGGATGGAT GGCTAAGGGC AGAGTTGGAT ACCCCATTGT GAAGCCAGGG 
CCCAACTGTG GATTTGGAAA AACTGGCATT ATTGATTATG GAATCCGTCT CAATAGGAGT 
GAAAGATGGG ATGCCTATTG CTACAACCCA CACGCAAAGG AGTGTGGTGG CGTCTTTACA 
GATCCAAAGC AAATTTTTAA ATCTCCAGGC TTCCCAAATG AGTACGAAGA TAACCAAATC 
TGCTACTGGC ACATTAGACT CAAGTATGGT CAGCGTATTC ACCTGAGTTT TTTAGATTTT 
GACCTTGAAG ATGACCCAGG TTGCTTGGCT GATTATGTTG AAATATATGA CAGTTACGAT 
GATGTCCATG GCTTTGTGGG AAGATACTGT GGAGATGAGC TTCCAGATGA CATCATCAGT 
ACAGGAAATG TCATGACCTT GAAGTTTCTA AGTGATGCTT CAGTGACAGC TGGAGGTTTC 
CAAATCAAAT ATGTTGCAAT GGATCCTGTA TCCAAATCCA GTCAAGGAAA AAATACAAGT 
ACTACTTCTA CTGGAAATAA AAACTTTTTA GCTGGAAGAT TTAGCCACTT ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_009046.2
CDS	76..909
Translation	MIILIYLFLLLWEDTQGWGFKDGIFHNSIWLERAAGVYHREARSGKYKLTYAEAKAVCEFEGGHLATYKQLEAARKIGFHVCAAGWMAKGRVGYPIVKPGPNCGFGKTGIIDYGIRLNRSERWDAYCYNPHAKECGGVFTDPKQIFKSPGFPNEYEDNQICYWHIRLKYGQRIHLSFLDFDLEDDPGCLADYVEIYDSYDDVHGFVGRYCGDELPDDIISTGNVMTLKFLSDASVTAGGFQIKYVAMDPVSKSSQGKNTSTTSTGNKNFLAGRFSHL

Target ORF information:

RefSeq Version	NM_007115.4
Organism	Homo sapiens(human)
Definition	Homo sapiens TNF alpha induced protein 6 (TNFAIP6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007115.4

ORF Insert Sequence:

ATGATCATCT TAATTTACTT ATTTCTCTTG CTATGGGAAG ACACTCAAGG ATGGGGATTC 
AAGGATGGAA TTTTTCATAA CTCCATATGG CTTGAACGAG CAGCCGGTGT GTACCACAGA 
GAAGCACGGT CTGGCAAATA CAAGCTCACC TACGCAGAAG CTAAGGCGGT GTGTGAATTT 
GAAGGCGGCC ATCTCGCAAC TTACAAGCAG CTAGAGGCAG CCAGAAAAAT TGGATTTCAT 
GTCTGTGCTG CTGGATGGAT GGCTAAGGGC AGAGTTGGAT ACCCCATTGT GAAGCCAGGG 
CCCAACTGTG GATTTGGAAA AACTGGCATT ATTGATTATG GAATCCGTCT CAATAGGAGT 
GAAAGATGGG ATGCCTATTG CTACAACCCA CACGCAAAGG AGTGTGGTGG CGTCTTTACA 
GATCCAAAGC AAATTTTTAA ATCTCCAGGC TTCCCAAATG AGTACGAAGA TAACCAAATC 
TGCTACTGGC ACATTAGACT CAAGTATGGT CAGCGTATTC ACCTGAGTTT TTTAGATTTT 
GACCTTGAAG ATGACCCAGG TTGCTTGGCT GATTATGTTG AAATATATGA CAGTTACGAT 
GATGTCCATG GCTTTGTGGG AAGATACTGT GGAGATGAGC TTCCAGATGA CATCATCAGT 
ACAGGAAATG TCATGACCTT GAAGTTTCTA AGTGATGCTT CAGTGACAGC TGGAGGTTTC 
CAAATCAAAT ATGTTGCAAT GGATCCTGTA TCCAAATCCA GTCAAGGAAA AAATACAAGT 
ACTACTTCTA CTGGAAATAA AAACTTTTTA GCTGGAAGAT TTAGCCACTT ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TNFAIP6 ( NM_007115.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_009046.2 Homo sapiens TNF alpha induced protein 6 (TNFAIP6), mRNA.

Price & Availability↑

CloneID	OHu23157
Clone ID Related Accession (Same CDS sequence)	NM_007115.4 , NM_007115.3
Accession Version	NM_007115.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 834bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-17
Organism	Homo sapiens(human)
Product	tumor necrosis factor-inducible gene 6 protein precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AU102580.1, BC030205.1, AC009311.3 and CA307541.1. On Dec 17, 2010 this sequence version replaced NM_007115.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC030205.1, M31165.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGATCATCT TAATTTACTT ATTTCTCTTG CTATGGGAAG ACACTCAAGG ATGGGGATTC 
AAGGATGGAA TTTTTCATAA CTCCATATGG CTTGAACGAG CAGCCGGTGT GTACCACAGA 
GAAGCACGGT CTGGCAAATA CAAGCTCACC TACGCAGAAG CTAAGGCGGT GTGTGAATTT 
GAAGGCGGCC ATCTCGCAAC TTACAAGCAG CTAGAGGCAG CCAGAAAAAT TGGATTTCAT 
GTCTGTGCTG CTGGATGGAT GGCTAAGGGC AGAGTTGGAT ACCCCATTGT GAAGCCAGGG 
CCCAACTGTG GATTTGGAAA AACTGGCATT ATTGATTATG GAATCCGTCT CAATAGGAGT 
GAAAGATGGG ATGCCTATTG CTACAACCCA CACGCAAAGG AGTGTGGTGG CGTCTTTACA 
GATCCAAAGC AAATTTTTAA ATCTCCAGGC TTCCCAAATG AGTACGAAGA TAACCAAATC 
TGCTACTGGC ACATTAGACT CAAGTATGGT CAGCGTATTC ACCTGAGTTT TTTAGATTTT 
GACCTTGAAG ATGACCCAGG TTGCTTGGCT GATTATGTTG AAATATATGA CAGTTACGAT 
GATGTCCATG GCTTTGTGGG AAGATACTGT GGAGATGAGC TTCCAGATGA CATCATCAGT 
ACAGGAAATG TCATGACCTT GAAGTTTCTA AGTGATGCTT CAGTGACAGC TGGAGGTTTC 
CAAATCAAAT ATGTTGCAAT GGATCCTGTA TCCAAATCCA GTCAAGGAAA AAATACAAGT 
ACTACTTCTA CTGGAAATAA AAACTTTTTA GCTGGAAGAT TTAGCCACTT ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_009046.2
CDS	76..909
Translation	MIILIYLFLLLWEDTQGWGFKDGIFHNSIWLERAAGVYHREARSGKYKLTYAEAKAVCEFEGGHLATYKQLEAARKIGFHVCAAGWMAKGRVGYPIVKPGPNCGFGKTGIIDYGIRLNRSERWDAYCYNPHAKECGGVFTDPKQIFKSPGFPNEYEDNQICYWHIRLKYGQRIHLSFLDFDLEDDPGCLADYVEIYDSYDDVHGFVGRYCGDELPDDIISTGNVMTLKFLSDASVTAGGFQIKYVAMDPVSKSSQGKNTSTTSTGNKNFLAGRFSHL

Target ORF information:

RefSeq Version	NM_007115.3
Organism	Homo sapiens(human)
Definition	Homo sapiens TNF alpha induced protein 6 (TNFAIP6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007115.3

ORF Insert Sequence:

ATGATCATCT TAATTTACTT ATTTCTCTTG CTATGGGAAG ACACTCAAGG ATGGGGATTC 
AAGGATGGAA TTTTTCATAA CTCCATATGG CTTGAACGAG CAGCCGGTGT GTACCACAGA 
GAAGCACGGT CTGGCAAATA CAAGCTCACC TACGCAGAAG CTAAGGCGGT GTGTGAATTT 
GAAGGCGGCC ATCTCGCAAC TTACAAGCAG CTAGAGGCAG CCAGAAAAAT TGGATTTCAT 
GTCTGTGCTG CTGGATGGAT GGCTAAGGGC AGAGTTGGAT ACCCCATTGT GAAGCCAGGG 
CCCAACTGTG GATTTGGAAA AACTGGCATT ATTGATTATG GAATCCGTCT CAATAGGAGT 
GAAAGATGGG ATGCCTATTG CTACAACCCA CACGCAAAGG AGTGTGGTGG CGTCTTTACA 
GATCCAAAGC AAATTTTTAA ATCTCCAGGC TTCCCAAATG AGTACGAAGA TAACCAAATC 
TGCTACTGGC ACATTAGACT CAAGTATGGT CAGCGTATTC ACCTGAGTTT TTTAGATTTT 
GACCTTGAAG ATGACCCAGG TTGCTTGGCT GATTATGTTG AAATATATGA CAGTTACGAT 
GATGTCCATG GCTTTGTGGG AAGATACTGT GGAGATGAGC TTCCAGATGA CATCATCAGT 
ACAGGAAATG TCATGACCTT GAAGTTTCTA AGTGATGCTT CAGTGACAGC TGGAGGTTTC 
CAAATCAAAT ATGTTGCAAT GGATCCTGTA TCCAAATCCA GTCAAGGAAA AAATACAAGT 
ACTACTTCTA CTGGAAATAA AAACTTTTTA GCTGGAAGAT TTAGCCACTT ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

TSG-6 is highly expressed in human abdominal aortic aneurysms.
The Journal of surgical research220311-319(2017 Dec)
Wang SK,Xie J,Green LA,McCready RA,Motaganahalli RL,Fajardo A,Babbey CC,Murphy MP

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TNFAIP6 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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