Gene Symbol | TNFAIP3 |
Entrez Gene ID | 7128 |
Full Name | TNF alpha induced protein 3 |
Synonyms | A20,AISBL,OTUD7C,TNFA1P2 |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2012]. |
Disorder MIM: | |
Disorder Html: | Autoinflammatory syndrome, familial, Behcet-like, 616744 (3) |