TNFAIP1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TNFAIP1
Entrez Gene ID	7126
Full Name	TNF alpha induced protein 1
Synonyms	B12,B61,BTBD34,EDP1,hBACURD2
General protein information	Preferred Names TNF alpha induced protein 1 Names BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 BTB/POZ domain-containing protein TNFAIP1 tumor necrosis factor, alpha induced protein 1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q11.2
Summary	This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is developmentally regulated in a tissue-specific manner. [provided by RefSeq, Jul 2008].
Disorder MIM:	191161

mRNA and Protein(s)

mRNA	Protein	Name
XM_017024993.2	XP_016880482.1	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 isoform X1
NM_021137.5	NP_066960.1	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
NM_021137.4	NP_066960.1	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
XM_017024993.1	XP_016880482.1	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	TNFAIP1	NP_066960.1
	TNFAIP1	XP_001106630.1
Bos taurus (cattle)	TNFAIP1	NP_001179219.1
Mus musculus (house mouse)	Tnfaip1	NP_001152864.1
Canis lupus familiaris (dog)	TNFAIP1	XP_548281.2
Rattus norvegicus (Norway rat)	Tnfaip1	NP_891995.1
Gallus gallus (chicken)	TNFAIP1	NP_001025897.1
Danio rerio (zebrafish)	tnfaip1	NP_956093.1
Pan troglodytes (chimpanzee)	TNFAIP1	XP_001147285.2
Xenopus tropicalis (tropical clawed frog)	tnfaip1	NP_001016809.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

MiR-424 Promotes Non-Small Cell Lung Cancer Progression and Metastasis through Regulating the Tumor Suppressor Gene TNFAIP1.
Zhang M, Gao C, Yang Y, Li G, Dong J, Ai Y, Ma Q, Li W
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology42(1)211-221(2017)

An inter-species protein-protein interaction network across vast evolutionary distance.
Zhong Q, Pevzner SJ, Hao T, Wang Y, Mosca R, Menche J, Taipale M, Ta?an M, Fan C, Yang X, Haley P, Murray RR, Mer F, Gebreab F, Tam S, MacWilliams A, Dricot A, Reichert P, Santhanam B, Ghamsari L, Calderwood MA, Rolland T, Charloteaux B, Lindquist S, Barab?si AL, Hill DE, Aloy P, Cusick ME, Xia Y, Roth FP, Vidal M
Molecular systems biology12(4)865(2016 Apr)

Transcription factor cyclic adenosine monophosphate responsive element binding protein negatively regulates tumor necrosis factor alpha-induced protein 1 expression.
Liu N, Wei K, Xun Y, Yang X, Gan S, Xiao H, Xiao Y, Yan F, Xie G, Wang T, Yang Y, Zhang J, Hu X, Xiang S
Molecular medicine reports12(5)7763-9(2015 Nov)

MiRNA-15a inhibits proliferation, migration and invasion by targeting TNFAIP1 in human osteosarcoma cells.
Tian X, Zhang J, Yan L, Dong JM, Guo Q
International journal of clinical and experimental pathology8(6)6442-9(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TNFAIP1 silence significantly increased the migrated and invaded cells compared to that in control, while these increases were abolished by miR-424 suppression.
Title: MiR-424 Promotes Non-Small Cell Lung Cancer Progression and Metastasis through Regulating the Tumor Suppressor Gene TNFAIP1.

MiR-181a played a critical role in regulating pancreatic cancer growth and migration, likely interacting with TNFAIP1.
Title: Interaction between microRNA-181a and TNFAIP1 regulates pancreatic cancer proliferation and migration.

CREB is a negative regulator of the TNFAIP1 gene.
Title: Transcription factor cyclic adenosine monophosphate responsive element binding protein negatively regulates tumor necrosis factor alpha-induced protein 1 expression.

TNFAIP1 plays an important role in mediating miR-15a dependent biological functions in osteosarcoma.
Title: MiRNA-15a inhibits proliferation, migration and invasion by targeting TNFAIP1 in human osteosarcoma cells.

Results showed that the expression of TNFAIP1 protein was significantly increased in osteosarcoma tissues and associated with distant metastasis.
Title: Knockdown of TNFAIP1 inhibits growth and induces apoptosis in osteosarcoma cells through inhibition of the nuclear factor-?B pathway.

The following TNFAIP1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TNFAIP1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu32121	NM_021137.5 Latest version!	Homo sapiens TNF alpha induced protein 1 (TNFAIP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu87438	XM_017024993.2 Latest version!	Homo sapiens TNF alpha induced protein 1 (TNFAIP1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
View Old Accession Versions >>
OHu32121	NM_021137.4	Homo sapiens TNF alpha induced protein 1 (TNFAIP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu87438	XM_017024993.1	Homo sapiens TNF alpha induced protein 1 (TNFAIP1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TNFAIP1 ( NM_021137.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_066960.1 Homo sapiens TNF alpha induced protein 1 (TNFAIP1), mRNA.

Price & Availability↑

CloneID	OHu32121
Clone ID Related Accession (Same CDS sequence)	NM_021137.5 , NM_021137.4
Accession Version	NM_021137.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 951bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC003694.2. On Nov 22, 2018 this sequence version replaced NM_021137.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC003694.2, SRR1803611.75799.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000226225.7/ ENSP00000226225.2 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCGGGGG ACACCTGCCT GTGCCCAGCC TCAGGGGCCA AGCCCAAGCT CAGTGGCTTC 
AAGGGAGGAG GGTTGGGCAA CAAGTATGTC CAGCTCAACG TGGGCGGCTC TCTGTACTAC 
ACCACTGTGC GGGCCCTGAC CCGCCACGAC ACCATGCTCA AGGCCATGTT CAGTGGGCGC 
ATGGAGGTGC TGACCGACAA AGAAGGCTGG ATCCTCATAG ACCGTTGTGG AAAGCACTTT 
GGCACCATTT TGAATTACCT CCGAGATGAC ACCATCACCC TCCCTCAGAA CCGGCAAGAA 
ATCAAGGAAT TGATGGCTGA AGCAAAGTAT TACCTCATCC AGGGGCTGGT GAATATGTGC 
CAGAGTGCCC TGCAGGACAA GAAGGACTCC TACCAGCCTG TGTGCAACAT CCCCATCATC 
ACATCCCTAA AGGAGGAGGA GCGGCTCATC GAATCCTCCA CCAAGCCCGT GGTGAAGCTG 
CTGTACAACA GAAGCAACAA CAAGTATTCC TACACCAGCA ACTCTGACGA CCACCTGCTG 
AAAAACATCG AGCTGTTTGA CAAGCTCTCC CTGCGCTTCA ACGGCCGCGT GCTCTTCATC 
AAGGATGTCA TTGGTGACGA GATCTGCTGC TGGTCCTTTT ATGGCCAGGG CCGTAAGCTG 
GCAGAGGTGT GCTGTACCTC CATCGTGTAT GCCACGGAGA AGAAGCAGAC CAAGGTGGAA 
TTCCCAGAGG CCCGAATCTA TGAGGAGACA CTCAACGTCC TACTCTATGA GACTCCCCGC 
GTCCCCGACA ACTCCTTGTT GGAGGCCACA AGCCGTAGCC GCAGCCAGGC TTCCCCCAGT 
GAAGATGAGG AGACCTTTGA ACTGCGGGAC CGTGTCCGCC GCATCCACGT CAAGCGCTAC 
AGCACTTACG ATGACCGGCA GCTCGGCCAC CAGTCTACCC ATCGCGACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_066960.1
CDS	211..1161
Translation	MSGDTCLCPASGAKPKLSGFKGGGLGNKYVQLNVGGSLYYTTVRALTRHDTMLKAMFSGRMEVLTDKEGWILIDRCGKHFGTILNYLRDDTITLPQNRQEIKELMAEAKYYLIQGLVNMCQSALQDKKDSYQPVCNIPIITSLKEEERLIESSTKPVVKLLYNRSNNKYSYTSNSDDHLLKNIELFDKLSLRFNGRVLFIKDVIGDEICCWSFYGQGRKLAEVCCTSIVYATEKKQTKVEFPEARIYEETLNVLLYETPRVPDNSLLEATSRSRSQASPSEDEETFELRDRVRRIHVKRYSTYDDRQLGHQSTHRD

Target ORF information:

RefSeq Version	NM_021137.5
Organism	Homo sapiens(human)
Definition	Homo sapiens TNF alpha induced protein 1 (TNFAIP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021137.5

ORF Insert Sequence:

ATGTCGGGGG ACACCTGCCT GTGCCCAGCC TCAGGGGCCA AGCCCAAGCT CAGTGGCTTC 
AAGGGAGGAG GGTTGGGCAA CAAGTATGTC CAGCTCAACG TGGGCGGCTC TCTGTACTAC 
ACCACTGTGC GGGCCCTGAC CCGCCACGAC ACCATGCTCA AGGCCATGTT CAGTGGGCGC 
ATGGAGGTGC TGACCGACAA AGAAGGCTGG ATCCTCATAG ACCGTTGTGG AAAGCACTTT 
GGCACCATTT TGAATTACCT CCGAGATGAC ACCATCACCC TCCCTCAGAA CCGGCAAGAA 
ATCAAGGAAT TGATGGCTGA AGCAAAGTAT TACCTCATCC AGGGGCTGGT GAATATGTGC 
CAGAGTGCCC TGCAGGACAA GAAGGACTCC TACCAGCCTG TGTGCAACAT CCCCATCATC 
ACATCCCTAA AGGAGGAGGA GCGGCTCATC GAATCCTCCA CCAAGCCCGT GGTGAAGCTG 
CTGTACAACA GAAGCAACAA CAAGTATTCC TACACCAGCA ACTCTGACGA CCACCTGCTG 
AAAAACATCG AGCTGTTTGA CAAGCTCTCC CTGCGCTTCA ACGGCCGCGT GCTCTTCATC 
AAGGATGTCA TTGGTGACGA GATCTGCTGC TGGTCCTTTT ATGGCCAGGG CCGTAAGCTG 
GCAGAGGTGT GCTGTACCTC CATCGTGTAT GCCACGGAGA AGAAGCAGAC CAAGGTGGAA 
TTCCCAGAGG CCCGAATCTA TGAGGAGACA CTCAACGTCC TACTCTATGA GACTCCCCGC 
GTCCCCGACA ACTCCTTGTT GGAGGCCACA AGCCGTAGCC GCAGCCAGGC TTCCCCCAGT 
GAAGATGAGG AGACCTTTGA ACTGCGGGAC CGTGTCCGCC GCATCCACGT CAAGCGCTAC 
AGCACTTACG ATGACCGGCA GCTCGGCCAC CAGTCTACCC ATCGCGACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TNFAIP1 ( NM_021137.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_066960.1 Homo sapiens TNF alpha induced protein 1 (TNFAIP1), mRNA.

Price & Availability↑

CloneID	OHu32121
Clone ID Related Accession (Same CDS sequence)	NM_021137.5 , NM_021137.4
Accession Version	NM_021137.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 951bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB093553.1 and BC003694.2. On Jan 24, 2009 this sequence version replaced NM_021137.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC003694.2, SRR1803611.75799.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCGGGGG ACACCTGCCT GTGCCCAGCC TCAGGGGCCA AGCCCAAGCT CAGTGGCTTC 
AAGGGAGGAG GGTTGGGCAA CAAGTATGTC CAGCTCAACG TGGGCGGCTC TCTGTACTAC 
ACCACTGTGC GGGCCCTGAC CCGCCACGAC ACCATGCTCA AGGCCATGTT CAGTGGGCGC 
ATGGAGGTGC TGACCGACAA AGAAGGCTGG ATCCTCATAG ACCGTTGTGG AAAGCACTTT 
GGCACCATTT TGAATTACCT CCGAGATGAC ACCATCACCC TCCCTCAGAA CCGGCAAGAA 
ATCAAGGAAT TGATGGCTGA AGCAAAGTAT TACCTCATCC AGGGGCTGGT GAATATGTGC 
CAGAGTGCCC TGCAGGACAA GAAGGACTCC TACCAGCCTG TGTGCAACAT CCCCATCATC 
ACATCCCTAA AGGAGGAGGA GCGGCTCATC GAATCCTCCA CCAAGCCCGT GGTGAAGCTG 
CTGTACAACA GAAGCAACAA CAAGTATTCC TACACCAGCA ACTCTGACGA CCACCTGCTG 
AAAAACATCG AGCTGTTTGA CAAGCTCTCC CTGCGCTTCA ACGGCCGCGT GCTCTTCATC 
AAGGATGTCA TTGGTGACGA GATCTGCTGC TGGTCCTTTT ATGGCCAGGG CCGTAAGCTG 
GCAGAGGTGT GCTGTACCTC CATCGTGTAT GCCACGGAGA AGAAGCAGAC CAAGGTGGAA 
TTCCCAGAGG CCCGAATCTA TGAGGAGACA CTCAACGTCC TACTCTATGA GACTCCCCGC 
GTCCCCGACA ACTCCTTGTT GGAGGCCACA AGCCGTAGCC GCAGCCAGGC TTCCCCCAGT 
GAAGATGAGG AGACCTTTGA ACTGCGGGAC CGTGTCCGCC GCATCCACGT CAAGCGCTAC 
AGCACTTACG ATGACCGGCA GCTCGGCCAC CAGTCTACCC ATCGCGACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_066960.1
CDS	450..1400
Translation	MSGDTCLCPASGAKPKLSGFKGGGLGNKYVQLNVGGSLYYTTVRALTRHDTMLKAMFSGRMEVLTDKEGWILIDRCGKHFGTILNYLRDDTITLPQNRQEIKELMAEAKYYLIQGLVNMCQSALQDKKDSYQPVCNIPIITSLKEEERLIESSTKPVVKLLYNRSNNKYSYTSNSDDHLLKNIELFDKLSLRFNGRVLFIKDVIGDEICCWSFYGQGRKLAEVCCTSIVYATEKKQTKVEFPEARIYEETLNVLLYETPRVPDNSLLEATSRSRSQASPSEDEETFELRDRVRRIHVKRYSTYDDRQLGHQSTHRD

Target ORF information:

RefSeq Version	NM_021137.4
Organism	Homo sapiens(human)
Definition	Homo sapiens TNF alpha induced protein 1 (TNFAIP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021137.4

ORF Insert Sequence:

ATGTCGGGGG ACACCTGCCT GTGCCCAGCC TCAGGGGCCA AGCCCAAGCT CAGTGGCTTC 
AAGGGAGGAG GGTTGGGCAA CAAGTATGTC CAGCTCAACG TGGGCGGCTC TCTGTACTAC 
ACCACTGTGC GGGCCCTGAC CCGCCACGAC ACCATGCTCA AGGCCATGTT CAGTGGGCGC 
ATGGAGGTGC TGACCGACAA AGAAGGCTGG ATCCTCATAG ACCGTTGTGG AAAGCACTTT 
GGCACCATTT TGAATTACCT CCGAGATGAC ACCATCACCC TCCCTCAGAA CCGGCAAGAA 
ATCAAGGAAT TGATGGCTGA AGCAAAGTAT TACCTCATCC AGGGGCTGGT GAATATGTGC 
CAGAGTGCCC TGCAGGACAA GAAGGACTCC TACCAGCCTG TGTGCAACAT CCCCATCATC 
ACATCCCTAA AGGAGGAGGA GCGGCTCATC GAATCCTCCA CCAAGCCCGT GGTGAAGCTG 
CTGTACAACA GAAGCAACAA CAAGTATTCC TACACCAGCA ACTCTGACGA CCACCTGCTG 
AAAAACATCG AGCTGTTTGA CAAGCTCTCC CTGCGCTTCA ACGGCCGCGT GCTCTTCATC 
AAGGATGTCA TTGGTGACGA GATCTGCTGC TGGTCCTTTT ATGGCCAGGG CCGTAAGCTG 
GCAGAGGTGT GCTGTACCTC CATCGTGTAT GCCACGGAGA AGAAGCAGAC CAAGGTGGAA 
TTCCCAGAGG CCCGAATCTA TGAGGAGACA CTCAACGTCC TACTCTATGA GACTCCCCGC 
GTCCCCGACA ACTCCTTGTT GGAGGCCACA AGCCGTAGCC GCAGCCAGGC TTCCCCCAGT 
GAAGATGAGG AGACCTTTGA ACTGCGGGAC CGTGTCCGCC GCATCCACGT CAAGCGCTAC 
AGCACTTACG ATGACCGGCA GCTCGGCCAC CAGTCTACCC ATCGCGACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TNFAIP1 ( XM_017024993.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_016880482.1 Homo sapiens TNF alpha induced protein 1 (TNFAIP1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu87438
Clone ID Related Accession (Same CDS sequence)	XM_017024993.2 , XM_017024993.1
Accession Version	XM_017024993.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1176bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017024993.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCGGGGG ACACCTGCCT GTGCCCAGCC TCAGGGGCCA AGCCCAAGCT CAGTGGCTTC 
AAGGGAGGAG GGTTGGGCAA CAAGTATGTC CAGCTCAACG TGGGCGGCTC TCTGTACTAC 
ACCACTGTGC GGGCCCTGAC CCGCCACGAC ACCATGCTCA AGGCCATGTT CAGTGGGCGC 
ATGGAGGTGC TGACCGACAA AGAAGGCTGG ATCCTCATAG ACCGTTGTGG AAAGCACTTT 
GGCACCATTT TGAATTACCT CCGAGATGAC ACCATCACCC TCCCTCAGAA CCGGCAAGAA 
ATCAAGGAAT TGATGGCTGA AGCAAAGTAT TACCTCATCC AGGGGCTGGT GAATATGTGC 
CAGAGTGCCC TGCAGGACAA GAAGGACTCC TACCAGCCTG TGTGCAACAT CCCCATCATC 
ACATCCCTAA AGGAGGAGGA GCGGCTCATC GAATCCTCCA CCAAGCCCGT GGTGAAGCTG 
CTGTACAACA GAAGCAACAA CAAGTATTCC TACACCAGCA ACTCTGACGA CCACCTGCTG 
AAAAACATCG AGCTGTTTGA CAAGCTCTCC CTGCGCTTCA ACGGCCGCGT GCTCTTCATC 
AAGGATGTCA TTGGTGACGA GATCTGCTGC TGGTCCTTTT ATGGCCAGGG CCGTAAGCTG 
GCAGAGGTGT GCTGTACCTC CATCGTGTAT GCCACGGAGA AGAAGCAGAC CAAGGTGTGG 
GGGATTGCCC CTGCCTGGGT AGGGGAGGAC ACACACCCAC TGTGCGGGGG ACGTGGTCGG 
GCTGTGACCA GCACGGAGCA AAAGGGGCAT GGACTTGGCT CTTTTTTCCA AACACGGTGG 
AATTCCCAGA GGCCCGAATC TATGAGGAGA CACTCAACGT CCTACTCTAT GAGACTCCCC 
GCGTCCCCGA CAACTCCTTG TTGGAGGCCA CAAGCCGTAG CCGCAGCCAG GCTTCCCCCA 
GTGAAGATGA GGAGACCTTT GAACTGCGGG ACCGTGTCCG CCGCATCCAC GTCAAGCGCT 
ACAGCACTTA CGATGACCGG CAGCTCGGCC ACCAGTCTAC CCATCGCGAC TGACCAGACC 
CTCAGGGAGT CAGGGCACGG GAGGCCCTAT CTCCCATCCT GTGGAACCCG CCCCATTGGC 
CACCCCATGC TGCTGCTGCC TGGGTCTCTG CTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016880482.1
CDS	301..1476
Translation	MSGDTCLCPASGAKPKLSGFKGGGLGNKYVQLNVGGSLYYTTVRALTRHDTMLKAMFSGRMEVLTDKEGWILIDRCGKHFGTILNYLRDDTITLPQNRQEIKELMAEAKYYLIQGLVNMCQSALQDKKDSYQPVCNIPIITSLKEEERLIESSTKPVVKLLYNRSNNKYSYTSNSDDHLLKNIELFDKLSLRFNGRVLFIKDVIGDEICCWSFYGQGRKLAEVCCTSIVYATEKKQTKVWGIAPAWVGEDTHPLCGGRGRAVTSTEQKGHGLGSFFQTRWNSQRPESMRRHSTSYSMRLPASPTTPCWRPQAVAAARLPPVKMRRPLNCGTVSAASTSSATALTMTGSSATSLPIATDQTLRESGHGRPYLPSCGTRPIGHPMLLLPGSLL

Target ORF information:

RefSeq Version	XM_017024993.2
Organism	Homo sapiens(human)
Definition	Homo sapiens TNF alpha induced protein 1 (TNFAIP1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017024993.2

ORF Insert Sequence:

ATGTCGGGGG ACACCTGCCT GTGCCCAGCC TCAGGGGCCA AGCCCAAGCT CAGTGGCTTC 
AAGGGAGGAG GGTTGGGCAA CAAGTATGTC CAGCTCAACG TGGGCGGCTC TCTGTACTAC 
ACCACTGTGC GGGCCCTGAC CCGCCACGAC ACCATGCTCA AGGCCATGTT CAGTGGGCGC 
ATGGAGGTGC TGACCGACAA AGAAGGCTGG ATCCTCATAG ACCGTTGTGG AAAGCACTTT 
GGCACCATTT TGAATTACCT CCGAGATGAC ACCATCACCC TCCCTCAGAA CCGGCAAGAA 
ATCAAGGAAT TGATGGCTGA AGCAAAGTAT TACCTCATCC AGGGGCTGGT GAATATGTGC 
CAGAGTGCCC TGCAGGACAA GAAGGACTCC TACCAGCCTG TGTGCAACAT CCCCATCATC 
ACATCCCTAA AGGAGGAGGA GCGGCTCATC GAATCCTCCA CCAAGCCCGT GGTGAAGCTG 
CTGTACAACA GAAGCAACAA CAAGTATTCC TACACCAGCA ACTCTGACGA CCACCTGCTG 
AAAAACATCG AGCTGTTTGA CAAGCTCTCC CTGCGCTTCA ACGGCCGCGT GCTCTTCATC 
AAGGATGTCA TTGGTGACGA GATCTGCTGC TGGTCCTTTT ATGGCCAGGG CCGTAAGCTG 
GCAGAGGTGT GCTGTACCTC CATCGTGTAT GCCACGGAGA AGAAGCAGAC CAAGGTGTGG 
GGGATTGCCC CTGCCTGGGT AGGGGAGGAC ACACACCCAC TGTGCGGGGG ACGTGGTCGG 
GCTGTGACCA GCACGGAGCA AAAGGGGCAT GGACTTGGCT CTTTTTTCCA AACACGGTGG 
AATTCCCAGA GGCCCGAATC TATGAGGAGA CACTCAACGT CCTACTCTAT GAGACTCCCC 
GCGTCCCCGA CAACTCCTTG TTGGAGGCCA CAAGCCGTAG CCGCAGCCAG GCTTCCCCCA 
GTGAAGATGA GGAGACCTTT GAACTGCGGG ACCGTGTCCG CCGCATCCAC GTCAAGCGCT 
ACAGCACTTA CGATGACCGG CAGCTCGGCC ACCAGTCTAC CCATCGCGAC TGACCAGACC 
CTCAGGGAGT CAGGGCACGG GAGGCCCTAT CTCCCATCCT GTGGAACCCG CCCCATTGGC 
CACCCCATGC TGCTGCTGCC TGGGTCTCTG CTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TNFAIP1 ( XM_017024993.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016880482.1 Homo sapiens TNF alpha induced protein 1 (TNFAIP1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu87438
Clone ID Related Accession (Same CDS sequence)	XM_017024993.2 , XM_017024993.1
Accession Version	XM_017024993.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1176bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCGGGGG ACACCTGCCT GTGCCCAGCC TCAGGGGCCA AGCCCAAGCT CAGTGGCTTC 
AAGGGAGGAG GGTTGGGCAA CAAGTATGTC CAGCTCAACG TGGGCGGCTC TCTGTACTAC 
ACCACTGTGC GGGCCCTGAC CCGCCACGAC ACCATGCTCA AGGCCATGTT CAGTGGGCGC 
ATGGAGGTGC TGACCGACAA AGAAGGCTGG ATCCTCATAG ACCGTTGTGG AAAGCACTTT 
GGCACCATTT TGAATTACCT CCGAGATGAC ACCATCACCC TCCCTCAGAA CCGGCAAGAA 
ATCAAGGAAT TGATGGCTGA AGCAAAGTAT TACCTCATCC AGGGGCTGGT GAATATGTGC 
CAGAGTGCCC TGCAGGACAA GAAGGACTCC TACCAGCCTG TGTGCAACAT CCCCATCATC 
ACATCCCTAA AGGAGGAGGA GCGGCTCATC GAATCCTCCA CCAAGCCCGT GGTGAAGCTG 
CTGTACAACA GAAGCAACAA CAAGTATTCC TACACCAGCA ACTCTGACGA CCACCTGCTG 
AAAAACATCG AGCTGTTTGA CAAGCTCTCC CTGCGCTTCA ACGGCCGCGT GCTCTTCATC 
AAGGATGTCA TTGGTGACGA GATCTGCTGC TGGTCCTTTT ATGGCCAGGG CCGTAAGCTG 
GCAGAGGTGT GCTGTACCTC CATCGTGTAT GCCACGGAGA AGAAGCAGAC CAAGGTGTGG 
GGGATTGCCC CTGCCTGGGT AGGGGAGGAC ACACACCCAC TGTGCGGGGG ACGTGGTCGG 
GCTGTGACCA GCACGGAGCA AAAGGGGCAT GGACTTGGCT CTTTTTTCCA AACACGGTGG 
AATTCCCAGA GGCCCGAATC TATGAGGAGA CACTCAACGT CCTACTCTAT GAGACTCCCC 
GCGTCCCCGA CAACTCCTTG TTGGAGGCCA CAAGCCGTAG CCGCAGCCAG GCTTCCCCCA 
GTGAAGATGA GGAGACCTTT GAACTGCGGG ACCGTGTCCG CCGCATCCAC GTCAAGCGCT 
ACAGCACTTA CGATGACCGG CAGCTCGGCC ACCAGTCTAC CCATCGCGAC TGACCAGACC 
CTCAGGGAGT CAGGGCACGG GAGGCCCTAT CTCCCATCCT GTGGAACCCG CCCCATTGGC 
CACCCCATGC TGCTGCTGCC TGGGTCTCTG CTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016880482.1
CDS	406..1581
Translation	MSGDTCLCPASGAKPKLSGFKGGGLGNKYVQLNVGGSLYYTTVRALTRHDTMLKAMFSGRMEVLTDKEGWILIDRCGKHFGTILNYLRDDTITLPQNRQEIKELMAEAKYYLIQGLVNMCQSALQDKKDSYQPVCNIPIITSLKEEERLIESSTKPVVKLLYNRSNNKYSYTSNSDDHLLKNIELFDKLSLRFNGRVLFIKDVIGDEICCWSFYGQGRKLAEVCCTSIVYATEKKQTKVWGIAPAWVGEDTHPLCGGRGRAVTSTEQKGHGLGSFFQTRWNSQRPESMRRHSTSYSMRLPASPTTPCWRPQAVAAARLPPVKMRRPLNCGTVSAASTSSATALTMTGSSATSLPIATDQTLRESGHGRPYLPSCGTRPIGHPMLLLPGSLL

Target ORF information:

RefSeq Version	XM_017024993.1
Organism	Homo sapiens(human)
Definition	Homo sapiens TNF alpha induced protein 1 (TNFAIP1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017024993.1

ORF Insert Sequence:

ATGTCGGGGG ACACCTGCCT GTGCCCAGCC TCAGGGGCCA AGCCCAAGCT CAGTGGCTTC 
AAGGGAGGAG GGTTGGGCAA CAAGTATGTC CAGCTCAACG TGGGCGGCTC TCTGTACTAC 
ACCACTGTGC GGGCCCTGAC CCGCCACGAC ACCATGCTCA AGGCCATGTT CAGTGGGCGC 
ATGGAGGTGC TGACCGACAA AGAAGGCTGG ATCCTCATAG ACCGTTGTGG AAAGCACTTT 
GGCACCATTT TGAATTACCT CCGAGATGAC ACCATCACCC TCCCTCAGAA CCGGCAAGAA 
ATCAAGGAAT TGATGGCTGA AGCAAAGTAT TACCTCATCC AGGGGCTGGT GAATATGTGC 
CAGAGTGCCC TGCAGGACAA GAAGGACTCC TACCAGCCTG TGTGCAACAT CCCCATCATC 
ACATCCCTAA AGGAGGAGGA GCGGCTCATC GAATCCTCCA CCAAGCCCGT GGTGAAGCTG 
CTGTACAACA GAAGCAACAA CAAGTATTCC TACACCAGCA ACTCTGACGA CCACCTGCTG 
AAAAACATCG AGCTGTTTGA CAAGCTCTCC CTGCGCTTCA ACGGCCGCGT GCTCTTCATC 
AAGGATGTCA TTGGTGACGA GATCTGCTGC TGGTCCTTTT ATGGCCAGGG CCGTAAGCTG 
GCAGAGGTGT GCTGTACCTC CATCGTGTAT GCCACGGAGA AGAAGCAGAC CAAGGTGTGG 
GGGATTGCCC CTGCCTGGGT AGGGGAGGAC ACACACCCAC TGTGCGGGGG ACGTGGTCGG 
GCTGTGACCA GCACGGAGCA AAAGGGGCAT GGACTTGGCT CTTTTTTCCA AACACGGTGG 
AATTCCCAGA GGCCCGAATC TATGAGGAGA CACTCAACGT CCTACTCTAT GAGACTCCCC 
GCGTCCCCGA CAACTCCTTG TTGGAGGCCA CAAGCCGTAG CCGCAGCCAG GCTTCCCCCA 
GTGAAGATGA GGAGACCTTT GAACTGCGGG ACCGTGTCCG CCGCATCCAC GTCAAGCGCT 
ACAGCACTTA CGATGACCGG CAGCTCGGCC ACCAGTCTAC CCATCGCGAC TGACCAGACC 
CTCAGGGAGT CAGGGCACGG GAGGCCCTAT CTCCCATCCT GTGGAACCCG CCCCATTGGC 
CACCCCATGC TGCTGCTGCC TGGGTCTCTG CTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

MiR-424 Promotes Non-Small Cell Lung Cancer Progression and Metastasis through Regulating the Tumor Suppressor Gene TNFAIP1.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology42(1)211-221(2017)
Zhang M,Gao C,Yang Y,Li G,Dong J,Ai Y,Ma Q,Li W

An inter-species protein-protein interaction network across vast evolutionary distance.
Molecular systems biology12(4)865(2016 Apr)
Zhong Q,Pevzner SJ,Hao T,Wang Y,Mosca R,Menche J,Taipale M,Ta?an M,Fan C,Yang X,Haley P,Murray RR,Mer F,Gebreab F,Tam S,MacWilliams A,Dricot A,Reichert P,Santhanam B,Ghamsari L,Calderwood MA,Rolland T,Charloteaux B,Lindquist S,Barab?si AL,Hill DE,Aloy P,Cusick ME,Xia Y,Roth FP,Vidal M

Transcription factor cyclic adenosine monophosphate responsive element binding protein negatively regulates tumor necrosis factor alpha-induced protein 1 expression.
Molecular medicine reports12(5)7763-9(2015 Nov)
Liu N,Wei K,Xun Y,Yang X,Gan S,Xiao H,Xiao Y,Yan F,Xie G,Wang T,Yang Y,Zhang J,Hu X,Xiang S

MiRNA-15a inhibits proliferation, migration and invasion by targeting TNFAIP1 in human osteosarcoma cells.
International journal of clinical and experimental pathology8(6)6442-9(2015)
Tian X,Zhang J,Yan L,Dong JM,Guo Q

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TNFAIP1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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