TLN1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TLN1
Entrez Gene ID	7094
Full Name	talin 1
Synonyms	ILWEQ,TLN,talin-1
General protein information	Preferred Names talin 1 Names talin-1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9p13.3
Summary	This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. [provided by RefSeq, Feb 2009].
Disorder MIM:	186745

mRNA and Protein(s)

mRNA	Protein	Name
NM_006289.4	NP_006280.3	talin-1
NM_006289.3	NP_006280.3	talin-1

Pathways from BioSystems

Homologies

	TLN1	XP_001084941.2
Gallus gallus (chicken)	TLN1	NP_989854.1
Pan troglodytes (chimpanzee)	TLN1	XP_003312119.1
Canis lupus familiaris (dog)	TLN1	XP_005626844.1
Homo sapiens (human)	TLN1	NP_006280.3
Bos taurus (cattle)	TLN1	NP_001192357.1
Mus musculus (house mouse)	Tln1	NP_035732.2
Rattus norvegicus (Norway rat)	Tln1	NP_001034114.2
Danio rerio (zebrafish)	tln1	NP_001009560.1

Gene Ontology
Bibliography

Related articles in PubMed

Integrin-bound talin head inhibits actin filament barbed end elongation.
Ciobanasu C, Wang H, Henriot V, Mathieu C, Fente A, Csillag S, Vigouroux C, Faivre B, Le Clainche C
The Journal of biological chemistry(2017 Dec)

Ecotopic viral integration site 1 (EVI1) transcriptionally targets talin1 (TLN1) and upregulates its expression in chronic myeloid leukemia.
Halder A, Nayak KB, Chakraborty S
Leukemia & lymphoma1-3(2017 Dec)

Multiplexing molecular tension sensors reveals piconewton force gradient across talin-1.
Ringer P, Wei?l A, Cost AL, Freikamp A, Sabass B, Mehlich A, Tramier M, Rief M, Grashoff C
Nature methods14(11)1090-1096(2017 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Application of these techniques to new talin biosensors reveals an intramolecular tension gradient across talin-1 that is established upon integrin-mediated cell adhesion. The tension gradient is actomyosin- and vinculin-dependent and sensitive to the rigidity of the extracellular environment
Title: Multiplexing molecular tension sensors reveals piconewton force gradient across talin-1.

Talin-1 induces proliferation and migration of vascular smooth muscle cells obtained from patients with thoracic aortic dissection.
Title: Downregulation of Talin-1 expression associates with increased proliferation and migration of vascular smooth muscle cells in aortic dissection.

The ERK pathway was responsible for these promoting effects of Talin1 knockdown in HCC cells.
Title: Downregulation of Talin1 promotes hepatocellular carcinoma progression through activation of the ERK1/2 pathway.

This study showed that serum sTalin-1 levels were associated with a sustained increase in disability after MS attack but not with serum anti-Talin-1 antibody levels.
Title: Serum soluble Talin-1 levels are elevated in patients with multiple sclerosis, reflecting its disease activity.

Our findings confirm the role of Talin-1 in carcinogenesis and provided a set of novel therapeutic targets for the treatment of hepatocellular carcinoma
Title: Talin-1 interaction network promotes hepatocellular carcinoma progression.

The following TLN1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TLN1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu12730	NM_006289.4 Latest version!	Homo sapiens talin 1 (TLN1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$659.50-$923.30 $1319.00
View Old Accession Versions >>
OHu12730	NM_006289.3	Homo sapiens talin 1 (TLN1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$659.50-$923.30 $1319.00
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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TLN1 ( NM_006289.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006280.3 Homo sapiens talin 1 (TLN1), mRNA.

Price & Availability↑

CloneID	OHu12730
Clone ID Related Accession (Same CDS sequence)	NM_006289.4 , NM_006289.3
Accession Version	NM_006289.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 7626bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-06
Organism	Homo sapiens(human)
Product	talin-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB028950.2 and AL133410.32. On Nov 22, 2018 this sequence version replaced NM_006289.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB028950.2, BC042923.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000314888.10/ ENSP00000316029.9 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGTTGCAC TTTCACTGAA GATCAGCATT GGGAATGTGG TGAAGACGAT GCAGTTTGAG 
CCGTCTACCA TGGTGTACGA CGCCTGCCGC ATCATTCGTG AGCGGATCCC AGAGGCCCCA 
GCTGGTCCTC CCAGCGACTT TGGGCTCTTT CTGTCAGATG ATGACCCCAA AAAGGGTATA 
TGGCTGGAGG CTGGGAAAGC TTTGGACTAC TACATGCTCC GAAATGGGGA CACTATGGAG 
TACAGGAAGA AACAGAGACC CCTGAAGATC CGTATGCTGG ATGGAACTGT GAAGACGATC 
ATGGTGGATG ACTCTAAGAC TGTCACTGAC ATGCTCATGA CCATCTGTGC CCGCATTGGC 
ATCACCAATC ATGATGAATA TTCATTGGTT CGAGAGCTGA TGGAAGAGAA AAAGGAGGAA 
ATAACAGGGA CCTTAAGAAA GGACAAGACA TTGCTGCGAG ATGAAAAGAA GATGGAGAAA 
CTAAAGCAGA AATTGCACAC AGATGATGAG TTGAACTGGC TGGACCATGG TCGGACACTG 
AGGGAGCAGG GTGTAGAGGA GCACGAGACG CTGCTGCTGC GGAGGAAGTT CTTTTACTCA 
GACCAGAATG TGGATTCCCG GGACCCTGTA CAGCTGAACC TCCTGTATGT GCAGGCACGA 
GATGACATCC TGAATGGCTC CCACCCTGTC TCCTTTGACA AGGCCTGTGA GTTTGCTGGC 
TTCCAATGCC AGATCCAGTT TGGGCCCCAC AATGAGCAGA AGCACAAGGC TGGCTTCCTT 
GACCTGAAGG ACTTCCTGCC CAAGGAGTAT GTGAAGCAGA AGGGAGAGCG TAAGATCTTC 
CAGGCACACA AGAATTGTGG GCAGATGAGT GAGATTGAGG CCAAGGTCCG CTACGTGAAG 
CTAGCCCGTT CTCTCAAGAC TTACGGTGTC TCCTTCTTCC TGGTGAAGGA AAAAATGAAA 
GGGAAGAACA AGCTAGTGCC CAGGCTTCTG GGCATCACCA AGGAGTGTGT GATGCGAGTG 
GATGAGAAGA CCAAGGAAGT GATCCAGGAG TGGAACCTCA CCAACATCAA ACGCTGGGCT 
GCGTCTCCCA AAAGCTTCAC CCTGGATTTT GGAGATTACC AAGATGGCTA TTACTCAGTA 
CAGACAACTG AAGGGGAGCA GATTGCACAG CTCATTGCCG GCTACATCGA TATCATCCTG 
AAGAAGAAAA AAAGCAAGGA TCACTTTGGG CTGGAAGGAG ATGAGGAGTC TACTATGCTG 
GAGGACTCAG TGTCCCCCAA AAAGTCAACA GTCCTGCAGC AGCAATACAA CCGGGTGGGG 
AAAGTGGAGC ATGGCTCTGT GGCCCTGCCT GCCATCATGC GCTCTGGAGC CTCTGGTCCT 
GAGAATTTCC AGGTGGGCAG CATGCCCCCT GCCCAGCAGC AGATTACCAG CGGCCAGATG 
CACCGAGGAC ACATGCCTCC TCTGACTTCA GCCCAGCAGG CACTCACTGG AACCATTAAC 
TCCAGCATGC AGGCCGTGCA GGCTGCCCAG GCCACCCTGG ATGACTTTGA CACTCTGCCG 
CCTCTTGGCC AGGATGCTGC CTCTAAGGCC TGGCGTAAAA ACAAGATGGA TGAATCAAAG 
CATGAGATCC ACTCTCAGGT AGATGCCATC ACAGCTGGTA CTGCGTCTGT GGTGAACCTG 
ACAGCAGGGG ACCCTGCTGA GACAGACTAT ACCGCAGTGG GCTGTGCAGT CACCACAATC 
TCCTCCAACC TGACGGAGAT GTCCCGTGGG GTGAAGCTGC TGGCTGCCTT GCTGGAGGAC 
GAAGGCGGCA GTGGTCGGCC CCTGTTGCAG GCAGCAAAGG GCCTTGCGGG AGCAGTGTCA 
GAACTGCTGC GCAGTGCCCA ACCAGCCAGT GCTGAGCCCC GTCAGAACCT GCTGCAAGCA 
GCTGGGAACG TGGGCCAGGC CAGTGGGGAG CTGTTGCAAC AAATTGGGGA AAGTGATACT 
GACCCCCACT TCCAGGATGC GCTAATGCAG CTCGCCAAAG CTGTGGCAAG TGCTGCAGCT 
GCCCTGGTCC TCAAGGCCAA GAGTGTGGCC CAGCGGACAG AGGACTCGGG ACTTCAGACC 
CAAGTTATTG CTGCAGCAAC ACAGTGTGCC CTATCCACTT CCCAACTAGT GGCCTGTACT 
AAGGTGGTGG CACCTACAAT CAGCTCACCT GTCTGCCAAG AGCAACTGGT GGAGGCTGGA 
CGACTGGTAG CCAAAGCCGT GGAGGGCTGT GTGTCTGCCT CCCAGGCAGC TACAGAGGAT 
GGGCAACTGT TGCGAGGGGT AGGAGCAGCA GCCACAGCTG TCACCCAGGC CCTAAATGAG 
CTGCTGCAGC ATGTGAAAGC CCATGCCACA GGGGCTGGGC CTGCTGGCCG TTATGACCAG 
GCTACTGACA CCATCCTAAC CGTCACTGAG AACATCTTTA GCTCCATGGG TGATGCTGGG 
GAGATGGTGC GACAGGCCCG CATCCTGGCC CAAGCCACAT CTGACCTGGT CAATGCCATC 
AAGGCTGATG CTGAGGGGGA AAGTGATCTG GAGAACTCCC GCAAGCTCTT AAGTGCTGCC 
AAGATCCTAG CTGATGCCAC AGCCAAGATG GTAGAGGCTG CCAAGGGAGC AGCTGCCCAC 
CCTGACAGTG AGGAGCAGCA GCAGCGGCTG CGGGAGGCAG CTGAGGGGCT GCGCATGGCC 
ACCAATGCAG CTGCGCAGAA TGCCATCAAG AAAAAGCTGG TGCAGCGCCT GGAGCATGCA 
GCCAAGCAGG CTGCAGCCTC AGCCACACAG ACCATCGCTG CAGCTCAGCA CGCAGCCTCT 
ACCCCCAAGG CCTCTGCCGG CCCCCAGCCC CTGCTGGTGC AGAGCTGCAA GGCAGTGGCA 
GAGCAGATTC CACTGCTGGT GCAGGGCGTC CGAGGAAGCC AAGCCCAGCC TGACAGCCCC 
AGCGCTCAGC TTGCCCTCAT TGCTGCCAGC CAGAGCTTCC TGCAGCCAGG TGGGAAGATG 
GTGGCAGCTG CAAAGGCCTC AGTGCCAACG ATTCAGGACC AGGCTTCAGC CATGCAGCTG 
AGTCAGTGTG CCAAGAACCT GGGCACCGCG CTGGCTGAAC TCCGGACGGC TGCCCAGAAG 
GCTCAGGAAG CATGTGGACC TTTGGAGATG GATTCTGCAC TGAGTGTGGT ACAGAATCTA 
GAGAAAGATC TACAGGAAGT GAAGGCAGCA GCTCGAGATG GCAAGCTTAA ACCCTTACCT 
GGGGAGACAA TGGAGAAGTG TACCCAGGAC CTGGGCAACA GCACCAAAGC CGTGAGCTCA 
GCCATCGCCC AGCTACTGGG AGAGGTTGCC CAGGGCAATG AGAATTATGC AGGTATTGCA 
GCTCGGGATG TGGCAGGTGG GCTGCGGTCA CTGGCCCAGG CCGCTAGGGG AGTCGCTGCA 
CTGACGTCAG ATCCTGCAGT GCAGGCCATT GTACTTGATA CGGCCAGTGA TGTGCTGGAC 
AAGGCCAGCA GCCTCATTGA GGAGGCGAAA AAGGCAGCTG GCCATCCAGG GGACCCTGAG 
AGCCAGCAGC GGCTTGCCCA GGTGGCTAAA GCAGTGACCC AGGCTCTGAA CCGCTGTGTC 
AGCTGCCTAC CTGGCCAGCG CGATGTGGAT AATGCCCTGA GGGCAGTTGG AGATGCCAGC 
AAGCGACTCC TGAGTGACTC GCTTCCTCCT AGCACTGGGA CATTTCAAGA AGCTCAGAGC 
CGGTTGAATG AAGCTGCTGC TGGGCTGAAT CAGGCAGCCA CAGAACTGGT GCAGGCCTCT 
CGGGGAACCC CTCAGGACCT GGCTCGAGCC TCAGGCCGAT TTGGACAGGA CTTCAGCACC 
TTCCTGGAAG CTGGTGTGGA GATGGCAGGC CAGGCTCCGA GCCAGGAGGA CCGAGCCCAA 
GTTGTGTCCA ACTTGAAGGG CATCTCCATG TCTTCAAGCA AACTTCTTCT GGCTGCCAAG 
GCCCTGTCCA CGGACCCTGC TGCCCCTAAC CTCAAGAGTC AGCTGGCTGC AGCTGCCAGG 
GCAGTAACTG ACAGCATCAA TCAGCTCATC ACTATGTGCA CCCAGCAGGC ACCCGGCCAG 
AAGGAGTGTG ATAACGCCCT GCGGGAATTG GAGACGGTCC GGGAACTCCT GGAGAACCCA 
GTCCAGCCCA TCAATGACAT GTCCTACTTT GGTTGCCTGG ACAGTGTAAT GGAGAACTCA 
AAGGTGCTGG GCGAGGCCAT GACTGGCATC TCCCAAAATG CCAAGAACGG AAACCTGCCA 
GAGTTTGGAG ATGCCATTTC CACAGCCTCA AAGGCACTTT GTGGCTTCAC CGAGGCAGCT 
GCACAGGCTG CATATCTGGT TGGTGTCTCT GACCCCAATA GCCAAGCTGG ACAGCAAGGG 
CTAGTGGAGC CCACACAGTT TGCCCGTGCA AACCAGGCAA TTCAGATGGC CTGCCAGAGT 
TTGGGAGAGC CTGGCTGTAC CCAGGCCCAG GTGCTCTCTG CAGCCACCAT TGTGGCTAAA 
CACACCTCTG CACTGTGTAA CAGCTGTCGC CTGGCTTCTG CCCGTACCAC CAATCCTACT 
GCCAAGCGCC AGTTTGTACA GTCAGCCAAG GAGGTGGCCA ACAGCACAGC TAATCTTGTC 
AAGACCATCA AGGCGCTAGA TGGGGCCTTC ACAGAGGAGA ACCGTGCCCA GTGCCGAGCA 
GCAACAGCCC CTCTGCTGGA GGCTGTGGAC AATCTGAGTG CCTTTGCGTC CAACCCTGAG 
TTCTCCAGCA TTCCTGCCCA GATCAGCCCT GAGGGTCGGG CTGCCATGGA GCCCATTGTG 
ATCTCTGCCA AGACAATGTT AGAGAGTGCC GGGGGACTCA TCCAGACAGC CCGGGCCCTC 
GCAGTCAATC CCCGGGACCC CCCGAGCTGG TCGGTGCTGG CCGGCCACTC CCGTACTGTC 
TCAGACTCCA TCAAGAAGCT AATTACAAGC ATGAGGGACA AGGCTCCAGG GCAGCTGGAG 
TGTGAAACGG CCATTGCAGC TCTGAACAGT TGTCTACGGG ACCTAGACCA GGCTTCCCTC 
GCTGCAGTCA GCCAGCAGCT TGCTCCCCGT GAGGGAATCT CTCAAGAGGC CTTGCACACT 
CAGATGCTCA CTGCAGTCCA AGAGATCTCC CATCTCATTG AGCCGCTGGC CAATGCTGCC 
CGGGCTGAAG CCTCCCAGCT GGGACACAAG GTGTCCCAGA TGGCGCAGTA CTTTGAGCCG 
CTCACCCTGG CTGCAGTGGG TGCTGCCTCC AAGACCCTGA GCCACCCGCA GCAGATGGCA 
CTCCTGGACC AGACTAAAAC ATTGGCAGAG TCTGCCCTGC AGTTGCTATA CACTGCCAAG 
GAGGCTGGTG GTAACCCAAA GCAAGCAGCT CACACCCAGG AAGCCCTGGA GGAGGCTGTG 
CAGATGATGA CCGAGGCCGT AGAGGACCTG ACAACAACCC TCAACGAGGC AGCCAGTGCT 
GCTGGGGTCG TGGGTGGCAT GGTGGACTCC ATCACCCAGG CCATCAACCA GCTAGATGAA 
GGACCAATGG GTGAACCAGA AGGTTCCTTC GTGGATTACC AAACAACTAT GGTGCGGACA 
GCCAAGGCCA TTGCAGTGAC CGTTCAGGAG ATGGTTACCA AGTCAAACAC CAGCCCAGAG 
GAGCTGGGCC CTCTTGCTAA CCAGCTGACC AGTGACTATG GCCGTCTGGC CTCGGAGGCC 
AAGCCTGCAG CGGTGGCTGC TGAAAATGAA GAGATAGGTT CCCATATCAA ACACCGGGTA 
CAGGAGCTGG GCCATGGCTG TGCCGCTCTG GTCACCAAGG CAGGCGCCCT GCAGTGCAGC 
CCCAGTGATG CCTACACCAA GAAGGAGCTC ATAGAGTGTG CCCGGAGAGT CTCTGAGAAG 
GTCTCCCACG TCCTGGCTGC GCTCCAGGCT GGGAATCGTG GCACCCAGGC CTGCATCACA 
GCAGCCAGCG CTGTGTCTGG TATCATTGCT GACCTCGACA CCACCATCAT GTTCGCCACT 
GCTGGCACGC TCAATCGTGA GGGTACTGAA ACTTTCGCTG ACCACCGGGA GGGCATCCTG 
AAGACTGCGA AGGTGCTGGT GGAGGACACC AAGGTCCTGG TGCAAAACGC AGCTGGGAGC 
CAGGAGAAGT TGGCGCAGGC TGCCCAGTCC TCCGTGGCGA CCATCACCCG CCTCGCTGAT 
GTGGTCAAGC TGGGTGCAGC CAGCCTGGGA GCTGAGGACC CTGAGACCCA GGTGGTACTA 
ATCAACGCAG TGAAAGATGT AGCCAAAGCC CTGGGAGACC TCATCAGTGC AACGAAGGCT 
GCAGCTGGCA AAGTTGGAGA TGACCCTGCT GTGTGGCAGC TAAAGAACTC TGCCAAGGTG 
ATGGTGACCA ATGTGACATC ATTGCTTAAG ACAGTAAAAG CCGTGGAAGA TGAGGCCACC 
AAAGGCACTC GGGCCCTGGA GGCAACCACA GAACACATAC GGCAGGAGCT GGCGGTTTTC 
TGTTCCCCAG AGCCACCTGC CAAGACCTCT ACCCCAGAAG ACTTCATCCG AATGACCAAG 
GGTATCACCA TGGCAACCGC CAAGGCCGTT GCTGCTGGCA ATTCCTGTCG CCAGGAAGAT 
GTCATTGCCA CAGCCAATCT GAGCCGCCGT GCTATTGCAG ATATGCTTCG GGCTTGCAAG 
GAAGCAGCTT ACCACCCAGA AGTGGCCCCT GATGTGCGGC TTCGAGCCCT GCACTATGGC 
CGGGAGTGTG CCAATGGCTA CCTGGAACTG CTGGACCATG TACTGCTGAC CCTGCAGAAG 
CCAAGCCCAG AACTGAAGCA GCAGTTGACA GGACATTCAA AGCGTGTGGC TGGTTCCGTC 
ACTGAGCTCA TCCAGGCTGC TGAAGCCATG AAGGGAACAG AATGGGTAGA CCCAGAGGAC 
CCCACAGTCA TTGCTGAGAA TGAGCTCCTG GGAGCTGCAG CCGCCATTGA GGCTGCAGCC 
AAAAAGCTAG AGCAGCTGAA GCCCCGGGCC AAACCCAAGG AGGCAGATGA GTCCTTGAAC 
TTTGAGGAGC AGATACTAGA AGCTGCCAAG TCCATTGCAG CAGCCACCAG TGCACTGGTA 
AAGGCTGCGT CGGCTGCCCA GAGAGAACTA GTGGCCCAAG GGAAGGTGGG TGCCATTCCA 
GCCAATGCAC TGGACGATGG GCAGTGGTCC CAGGGCCTCA TTTCTGCTGC CCGGATGGTG 
GCTGCGGCCA CCAACAATCT GTGTGAGGCA GCCAATGCAG CTGTACAAGG CCATGCCAGC 
CAGGAGAAGC TCATCTCATC AGCCAAGCAG GTAGCTGCCT CCACAGCCCA GCTCCTTGTG 
GCCTGCAAGG TCAAGGCTGA CCAGGACTCG GAGGCAATGA AACGACTTCA GGCTGCTGGC 
AACGCAGTGA AGCGAGCCTC AGATAATCTG GTGAAAGCAG CACAGAAGGC TGCAGCCTTT 
GAAGAGCAGG AGAATGAGAC AGTGGTGGTG AAAGAGAAGA TGGTTGGCGG CATTGCCCAG 
ATCATCGCAG CACAGGAAGA AATGCTTCGG AAGGAACGAG AGCTGGAAGA GGCGCGGAAG 
AAACTGGCCC AGATCCGGCA GCAGCAGTAC AAGTTTCTGC CTTCAGAGCT TCGAGATGAG 
CACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006280.3
CDS	155..7780
Translation	MVALSLKISIGNVVKTMQFEPSTMVYDACRIIRERIPEAPAGPPSDFGLFLSDDDPKKGIWLEAGKALDYYMLRNGDTMEYRKKQRPLKIRMLDGTVKTIMVDDSKTVTDMLMTICARIGITNHDEYSLVRELMEEKKEEITGTLRKDKTLLRDEKKMEKLKQKLHTDDELNWLDHGRTLREQGVEEHETLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPVSFDKACEFAGFQCQIQFGPHNEQKHKAGFLDLKDFLPKEYVKQKGERKIFQAHKNCGQMSEIEAKVRYVKLARSLKTYGVSFFLVKEKMKGKNKLVPRLLGITKECVMRVDEKTKEVIQEWNLTNIKRWAASPKSFTLDFGDYQDGYYSVQTTEGEQIAQLIAGYIDIILKKKKSKDHFGLEGDEESTMLEDSVSPKKSTVLQQQYNRVGKVEHGSVALPAIMRSGASGPENFQVGSMPPAQQQITSGQMHRGHMPPLTSAQQALTGTINSSMQAVQAAQATLDDFDTLPPLGQDAASKAWRKNKMDESKHEIHSQVDAITAGTASVVNLTAGDPAETDYTAVGCAVTTISSNLTEMSRGVKLLAALLEDEGGSGRPLLQAAKGLAGAVSELLRSAQPASAEPRQNLLQAAGNVGQASGELLQQIGESDTDPHFQDALMQLAKAVASAAAALVLKAKSVAQRTEDSGLQTQVIAAATQCALSTSQLVACTKVVAPTISSPVCQEQLVEAGRLVAKAVEGCVSASQAATEDGQLLRGVGAAATAVTQALNELLQHVKAHATGAGPAGRYDQATDTILTVTENIFSSMGDAGEMVRQARILAQATSDLVNAIKADAEGESDLENSRKLLSAAKILADATAKMVEAAKGAAAHPDSEEQQQRLREAAEGLRMATNAAAQNAIKKKLVQRLEHAAKQAAASATQTIAAAQHAASTPKASAGPQPLLVQSCKAVAEQIPLLVQGVRGSQAQPDSPSAQLALIAASQSFLQPGGKMVAAAKASVPTIQDQASAMQLSQCAKNLGTALAELRTAAQKAQEACGPLEMDSALSVVQNLEKDLQEVKAAARDGKLKPLPGETMEKCTQDLGNSTKAVSSAIAQLLGEVAQGNENYAGIAARDVAGGLRSLAQAARGVAALTSDPAVQAIVLDTASDVLDKASSLIEEAKKAAGHPGDPESQQRLAQVAKAVTQALNRCVSCLPGQRDVDNALRAVGDASKRLLSDSLPPSTGTFQEAQSRLNEAAAGLNQAATELVQASRGTPQDLARASGRFGQDFSTFLEAGVEMAGQAPSQEDRAQVVSNLKGISMSSSKLLLAAKALSTDPAAPNLKSQLAAAARAVTDSINQLITMCTQQAPGQKECDNALRELETVRELLENPVQPINDMSYFGCLDSVMENSKVLGEAMTGISQNAKNGNLPEFGDAISTASKALCGFTEAAAQAAYLVGVSDPNSQAGQQGLVEPTQFARANQAIQMACQSLGEPGCTQAQVLSAATIVAKHTSALCNSCRLASARTTNPTAKRQFVQSAKEVANSTANLVKTIKALDGAFTEENRAQCRAATAPLLEAVDNLSAFASNPEFSSIPAQISPEGRAAMEPIVISAKTMLESAGGLIQTARALAVNPRDPPSWSVLAGHSRTVSDSIKKLITSMRDKAPGQLECETAIAALNSCLRDLDQASLAAVSQQLAPREGISQEALHTQMLTAVQEISHLIEPLANAARAEASQLGHKVSQMAQYFEPLTLAAVGAASKTLSHPQQMALLDQTKTLAESALQLLYTAKEAGGNPKQAAHTQEALEEAVQMMTEAVEDLTTTLNEAASAAGVVGGMVDSITQAINQLDEGPMGEPEGSFVDYQTTMVRTAKAIAVTVQEMVTKSNTSPEELGPLANQLTSDYGRLASEAKPAAVAAENEEIGSHIKHRVQELGHGCAALVTKAGALQCSPSDAYTKKELIECARRVSEKVSHVLAALQAGNRGTQACITAASAVSGIIADLDTTIMFATAGTLNREGTETFADHREGILKTAKVLVEDTKVLVQNAAGSQEKLAQAAQSSVATITRLADVVKLGAASLGAEDPETQVVLINAVKDVAKALGDLISATKAAAGKVGDDPAVWQLKNSAKVMVTNVTSLLKTVKAVEDEATKGTRALEATTEHIRQELAVFCSPEPPAKTSTPEDFIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRRAIADMLRACKEAAYHPEVAPDVRLRALHYGRECANGYLELLDHVLLTLQKPSPELKQQLTGHSKRVAGSVTELIQAAEAMKGTEWVDPEDPTVIAENELLGAAAAIEAAAKKLEQLKPRAKPKEADESLNFEEQILEAAKSIAAATSALVKAASAAQRELVAQGKVGAIPANALDDGQWSQGLISAARMVAAATNNLCEAANAAVQGHASQEKLISSAKQVAASTAQLLVACKVKADQDSEAMKRLQAAGNAVKRASDNLVKAAQKAAAFEEQENETVVVKEKMVGGIAQIIAAQEEMLRKERELEEARKKLAQIRQQQYKFLPSELRDEH

Target ORF information:

RefSeq Version	NM_006289.4
Organism	Homo sapiens(human)
Definition	Homo sapiens talin 1 (TLN1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006289.4

ORF Insert Sequence:

ATGGTTGCAC TTTCACTGAA GATCAGCATT GGGAATGTGG TGAAGACGAT GCAGTTTGAG 
CCGTCTACCA TGGTGTACGA CGCCTGCCGC ATCATTCGTG AGCGGATCCC AGAGGCCCCA 
GCTGGTCCTC CCAGCGACTT TGGGCTCTTT CTGTCAGATG ATGACCCCAA AAAGGGTATA 
TGGCTGGAGG CTGGGAAAGC TTTGGACTAC TACATGCTCC GAAATGGGGA CACTATGGAG 
TACAGGAAGA AACAGAGACC CCTGAAGATC CGTATGCTGG ATGGAACTGT GAAGACGATC 
ATGGTGGATG ACTCTAAGAC TGTCACTGAC ATGCTCATGA CCATCTGTGC CCGCATTGGC 
ATCACCAATC ATGATGAATA TTCATTGGTT CGAGAGCTGA TGGAAGAGAA AAAGGAGGAA 
ATAACAGGGA CCTTAAGAAA GGACAAGACA TTGCTGCGAG ATGAAAAGAA GATGGAGAAA 
CTAAAGCAGA AATTGCACAC AGATGATGAG TTGAACTGGC TGGACCATGG TCGGACACTG 
AGGGAGCAGG GTGTAGAGGA GCACGAGACG CTGCTGCTGC GGAGGAAGTT CTTTTACTCA 
GACCAGAATG TGGATTCCCG GGACCCTGTA CAGCTGAACC TCCTGTATGT GCAGGCACGA 
GATGACATCC TGAATGGCTC CCACCCTGTC TCCTTTGACA AGGCCTGTGA GTTTGCTGGC 
TTCCAATGCC AGATCCAGTT TGGGCCCCAC AATGAGCAGA AGCACAAGGC TGGCTTCCTT 
GACCTGAAGG ACTTCCTGCC CAAGGAGTAT GTGAAGCAGA AGGGAGAGCG TAAGATCTTC 
CAGGCACACA AGAATTGTGG GCAGATGAGT GAGATTGAGG CCAAGGTCCG CTACGTGAAG 
CTAGCCCGTT CTCTCAAGAC TTACGGTGTC TCCTTCTTCC TGGTGAAGGA AAAAATGAAA 
GGGAAGAACA AGCTAGTGCC CAGGCTTCTG GGCATCACCA AGGAGTGTGT GATGCGAGTG 
GATGAGAAGA CCAAGGAAGT GATCCAGGAG TGGAACCTCA CCAACATCAA ACGCTGGGCT 
GCGTCTCCCA AAAGCTTCAC CCTGGATTTT GGAGATTACC AAGATGGCTA TTACTCAGTA 
CAGACAACTG AAGGGGAGCA GATTGCACAG CTCATTGCCG GCTACATCGA TATCATCCTG 
AAGAAGAAAA AAAGCAAGGA TCACTTTGGG CTGGAAGGAG ATGAGGAGTC TACTATGCTG 
GAGGACTCAG TGTCCCCCAA AAAGTCAACA GTCCTGCAGC AGCAATACAA CCGGGTGGGG 
AAAGTGGAGC ATGGCTCTGT GGCCCTGCCT GCCATCATGC GCTCTGGAGC CTCTGGTCCT 
GAGAATTTCC AGGTGGGCAG CATGCCCCCT GCCCAGCAGC AGATTACCAG CGGCCAGATG 
CACCGAGGAC ACATGCCTCC TCTGACTTCA GCCCAGCAGG CACTCACTGG AACCATTAAC 
TCCAGCATGC AGGCCGTGCA GGCTGCCCAG GCCACCCTGG ATGACTTTGA CACTCTGCCG 
CCTCTTGGCC AGGATGCTGC CTCTAAGGCC TGGCGTAAAA ACAAGATGGA TGAATCAAAG 
CATGAGATCC ACTCTCAGGT AGATGCCATC ACAGCTGGTA CTGCGTCTGT GGTGAACCTG 
ACAGCAGGGG ACCCTGCTGA GACAGACTAT ACCGCAGTGG GCTGTGCAGT CACCACAATC 
TCCTCCAACC TGACGGAGAT GTCCCGTGGG GTGAAGCTGC TGGCTGCCTT GCTGGAGGAC 
GAAGGCGGCA GTGGTCGGCC CCTGTTGCAG GCAGCAAAGG GCCTTGCGGG AGCAGTGTCA 
GAACTGCTGC GCAGTGCCCA ACCAGCCAGT GCTGAGCCCC GTCAGAACCT GCTGCAAGCA 
GCTGGGAACG TGGGCCAGGC CAGTGGGGAG CTGTTGCAAC AAATTGGGGA AAGTGATACT 
GACCCCCACT TCCAGGATGC GCTAATGCAG CTCGCCAAAG CTGTGGCAAG TGCTGCAGCT 
GCCCTGGTCC TCAAGGCCAA GAGTGTGGCC CAGCGGACAG AGGACTCGGG ACTTCAGACC 
CAAGTTATTG CTGCAGCAAC ACAGTGTGCC CTATCCACTT CCCAACTAGT GGCCTGTACT 
AAGGTGGTGG CACCTACAAT CAGCTCACCT GTCTGCCAAG AGCAACTGGT GGAGGCTGGA 
CGACTGGTAG CCAAAGCCGT GGAGGGCTGT GTGTCTGCCT CCCAGGCAGC TACAGAGGAT 
GGGCAACTGT TGCGAGGGGT AGGAGCAGCA GCCACAGCTG TCACCCAGGC CCTAAATGAG 
CTGCTGCAGC ATGTGAAAGC CCATGCCACA GGGGCTGGGC CTGCTGGCCG TTATGACCAG 
GCTACTGACA CCATCCTAAC CGTCACTGAG AACATCTTTA GCTCCATGGG TGATGCTGGG 
GAGATGGTGC GACAGGCCCG CATCCTGGCC CAAGCCACAT CTGACCTGGT CAATGCCATC 
AAGGCTGATG CTGAGGGGGA AAGTGATCTG GAGAACTCCC GCAAGCTCTT AAGTGCTGCC 
AAGATCCTAG CTGATGCCAC AGCCAAGATG GTAGAGGCTG CCAAGGGAGC AGCTGCCCAC 
CCTGACAGTG AGGAGCAGCA GCAGCGGCTG CGGGAGGCAG CTGAGGGGCT GCGCATGGCC 
ACCAATGCAG CTGCGCAGAA TGCCATCAAG AAAAAGCTGG TGCAGCGCCT GGAGCATGCA 
GCCAAGCAGG CTGCAGCCTC AGCCACACAG ACCATCGCTG CAGCTCAGCA CGCAGCCTCT 
ACCCCCAAGG CCTCTGCCGG CCCCCAGCCC CTGCTGGTGC AGAGCTGCAA GGCAGTGGCA 
GAGCAGATTC CACTGCTGGT GCAGGGCGTC CGAGGAAGCC AAGCCCAGCC TGACAGCCCC 
AGCGCTCAGC TTGCCCTCAT TGCTGCCAGC CAGAGCTTCC TGCAGCCAGG TGGGAAGATG 
GTGGCAGCTG CAAAGGCCTC AGTGCCAACG ATTCAGGACC AGGCTTCAGC CATGCAGCTG 
AGTCAGTGTG CCAAGAACCT GGGCACCGCG CTGGCTGAAC TCCGGACGGC TGCCCAGAAG 
GCTCAGGAAG CATGTGGACC TTTGGAGATG GATTCTGCAC TGAGTGTGGT ACAGAATCTA 
GAGAAAGATC TACAGGAAGT GAAGGCAGCA GCTCGAGATG GCAAGCTTAA ACCCTTACCT 
GGGGAGACAA TGGAGAAGTG TACCCAGGAC CTGGGCAACA GCACCAAAGC CGTGAGCTCA 
GCCATCGCCC AGCTACTGGG AGAGGTTGCC CAGGGCAATG AGAATTATGC AGGTATTGCA 
GCTCGGGATG TGGCAGGTGG GCTGCGGTCA CTGGCCCAGG CCGCTAGGGG AGTCGCTGCA 
CTGACGTCAG ATCCTGCAGT GCAGGCCATT GTACTTGATA CGGCCAGTGA TGTGCTGGAC 
AAGGCCAGCA GCCTCATTGA GGAGGCGAAA AAGGCAGCTG GCCATCCAGG GGACCCTGAG 
AGCCAGCAGC GGCTTGCCCA GGTGGCTAAA GCAGTGACCC AGGCTCTGAA CCGCTGTGTC 
AGCTGCCTAC CTGGCCAGCG CGATGTGGAT AATGCCCTGA GGGCAGTTGG AGATGCCAGC 
AAGCGACTCC TGAGTGACTC GCTTCCTCCT AGCACTGGGA CATTTCAAGA AGCTCAGAGC 
CGGTTGAATG AAGCTGCTGC TGGGCTGAAT CAGGCAGCCA CAGAACTGGT GCAGGCCTCT 
CGGGGAACCC CTCAGGACCT GGCTCGAGCC TCAGGCCGAT TTGGACAGGA CTTCAGCACC 
TTCCTGGAAG CTGGTGTGGA GATGGCAGGC CAGGCTCCGA GCCAGGAGGA CCGAGCCCAA 
GTTGTGTCCA ACTTGAAGGG CATCTCCATG TCTTCAAGCA AACTTCTTCT GGCTGCCAAG 
GCCCTGTCCA CGGACCCTGC TGCCCCTAAC CTCAAGAGTC AGCTGGCTGC AGCTGCCAGG 
GCAGTAACTG ACAGCATCAA TCAGCTCATC ACTATGTGCA CCCAGCAGGC ACCCGGCCAG 
AAGGAGTGTG ATAACGCCCT GCGGGAATTG GAGACGGTCC GGGAACTCCT GGAGAACCCA 
GTCCAGCCCA TCAATGACAT GTCCTACTTT GGTTGCCTGG ACAGTGTAAT GGAGAACTCA 
AAGGTGCTGG GCGAGGCCAT GACTGGCATC TCCCAAAATG CCAAGAACGG AAACCTGCCA 
GAGTTTGGAG ATGCCATTTC CACAGCCTCA AAGGCACTTT GTGGCTTCAC CGAGGCAGCT 
GCACAGGCTG CATATCTGGT TGGTGTCTCT GACCCCAATA GCCAAGCTGG ACAGCAAGGG 
CTAGTGGAGC CCACACAGTT TGCCCGTGCA AACCAGGCAA TTCAGATGGC CTGCCAGAGT 
TTGGGAGAGC CTGGCTGTAC CCAGGCCCAG GTGCTCTCTG CAGCCACCAT TGTGGCTAAA 
CACACCTCTG CACTGTGTAA CAGCTGTCGC CTGGCTTCTG CCCGTACCAC CAATCCTACT 
GCCAAGCGCC AGTTTGTACA GTCAGCCAAG GAGGTGGCCA ACAGCACAGC TAATCTTGTC 
AAGACCATCA AGGCGCTAGA TGGGGCCTTC ACAGAGGAGA ACCGTGCCCA GTGCCGAGCA 
GCAACAGCCC CTCTGCTGGA GGCTGTGGAC AATCTGAGTG CCTTTGCGTC CAACCCTGAG 
TTCTCCAGCA TTCCTGCCCA GATCAGCCCT GAGGGTCGGG CTGCCATGGA GCCCATTGTG 
ATCTCTGCCA AGACAATGTT AGAGAGTGCC GGGGGACTCA TCCAGACAGC CCGGGCCCTC 
GCAGTCAATC CCCGGGACCC CCCGAGCTGG TCGGTGCTGG CCGGCCACTC CCGTACTGTC 
TCAGACTCCA TCAAGAAGCT AATTACAAGC ATGAGGGACA AGGCTCCAGG GCAGCTGGAG 
TGTGAAACGG CCATTGCAGC TCTGAACAGT TGTCTACGGG ACCTAGACCA GGCTTCCCTC 
GCTGCAGTCA GCCAGCAGCT TGCTCCCCGT GAGGGAATCT CTCAAGAGGC CTTGCACACT 
CAGATGCTCA CTGCAGTCCA AGAGATCTCC CATCTCATTG AGCCGCTGGC CAATGCTGCC 
CGGGCTGAAG CCTCCCAGCT GGGACACAAG GTGTCCCAGA TGGCGCAGTA CTTTGAGCCG 
CTCACCCTGG CTGCAGTGGG TGCTGCCTCC AAGACCCTGA GCCACCCGCA GCAGATGGCA 
CTCCTGGACC AGACTAAAAC ATTGGCAGAG TCTGCCCTGC AGTTGCTATA CACTGCCAAG 
GAGGCTGGTG GTAACCCAAA GCAAGCAGCT CACACCCAGG AAGCCCTGGA GGAGGCTGTG 
CAGATGATGA CCGAGGCCGT AGAGGACCTG ACAACAACCC TCAACGAGGC AGCCAGTGCT 
GCTGGGGTCG TGGGTGGCAT GGTGGACTCC ATCACCCAGG CCATCAACCA GCTAGATGAA 
GGACCAATGG GTGAACCAGA AGGTTCCTTC GTGGATTACC AAACAACTAT GGTGCGGACA 
GCCAAGGCCA TTGCAGTGAC CGTTCAGGAG ATGGTTACCA AGTCAAACAC CAGCCCAGAG 
GAGCTGGGCC CTCTTGCTAA CCAGCTGACC AGTGACTATG GCCGTCTGGC CTCGGAGGCC 
AAGCCTGCAG CGGTGGCTGC TGAAAATGAA GAGATAGGTT CCCATATCAA ACACCGGGTA 
CAGGAGCTGG GCCATGGCTG TGCCGCTCTG GTCACCAAGG CAGGCGCCCT GCAGTGCAGC 
CCCAGTGATG CCTACACCAA GAAGGAGCTC ATAGAGTGTG CCCGGAGAGT CTCTGAGAAG 
GTCTCCCACG TCCTGGCTGC GCTCCAGGCT GGGAATCGTG GCACCCAGGC CTGCATCACA 
GCAGCCAGCG CTGTGTCTGG TATCATTGCT GACCTCGACA CCACCATCAT GTTCGCCACT 
GCTGGCACGC TCAATCGTGA GGGTACTGAA ACTTTCGCTG ACCACCGGGA GGGCATCCTG 
AAGACTGCGA AGGTGCTGGT GGAGGACACC AAGGTCCTGG TGCAAAACGC AGCTGGGAGC 
CAGGAGAAGT TGGCGCAGGC TGCCCAGTCC TCCGTGGCGA CCATCACCCG CCTCGCTGAT 
GTGGTCAAGC TGGGTGCAGC CAGCCTGGGA GCTGAGGACC CTGAGACCCA GGTGGTACTA 
ATCAACGCAG TGAAAGATGT AGCCAAAGCC CTGGGAGACC TCATCAGTGC AACGAAGGCT 
GCAGCTGGCA AAGTTGGAGA TGACCCTGCT GTGTGGCAGC TAAAGAACTC TGCCAAGGTG 
ATGGTGACCA ATGTGACATC ATTGCTTAAG ACAGTAAAAG CCGTGGAAGA TGAGGCCACC 
AAAGGCACTC GGGCCCTGGA GGCAACCACA GAACACATAC GGCAGGAGCT GGCGGTTTTC 
TGTTCCCCAG AGCCACCTGC CAAGACCTCT ACCCCAGAAG ACTTCATCCG AATGACCAAG 
GGTATCACCA TGGCAACCGC CAAGGCCGTT GCTGCTGGCA ATTCCTGTCG CCAGGAAGAT 
GTCATTGCCA CAGCCAATCT GAGCCGCCGT GCTATTGCAG ATATGCTTCG GGCTTGCAAG 
GAAGCAGCTT ACCACCCAGA AGTGGCCCCT GATGTGCGGC TTCGAGCCCT GCACTATGGC 
CGGGAGTGTG CCAATGGCTA CCTGGAACTG CTGGACCATG TACTGCTGAC CCTGCAGAAG 
CCAAGCCCAG AACTGAAGCA GCAGTTGACA GGACATTCAA AGCGTGTGGC TGGTTCCGTC 
ACTGAGCTCA TCCAGGCTGC TGAAGCCATG AAGGGAACAG AATGGGTAGA CCCAGAGGAC 
CCCACAGTCA TTGCTGAGAA TGAGCTCCTG GGAGCTGCAG CCGCCATTGA GGCTGCAGCC 
AAAAAGCTAG AGCAGCTGAA GCCCCGGGCC AAACCCAAGG AGGCAGATGA GTCCTTGAAC 
TTTGAGGAGC AGATACTAGA AGCTGCCAAG TCCATTGCAG CAGCCACCAG TGCACTGGTA 
AAGGCTGCGT CGGCTGCCCA GAGAGAACTA GTGGCCCAAG GGAAGGTGGG TGCCATTCCA 
GCCAATGCAC TGGACGATGG GCAGTGGTCC CAGGGCCTCA TTTCTGCTGC CCGGATGGTG 
GCTGCGGCCA CCAACAATCT GTGTGAGGCA GCCAATGCAG CTGTACAAGG CCATGCCAGC 
CAGGAGAAGC TCATCTCATC AGCCAAGCAG GTAGCTGCCT CCACAGCCCA GCTCCTTGTG 
GCCTGCAAGG TCAAGGCTGA CCAGGACTCG GAGGCAATGA AACGACTTCA GGCTGCTGGC 
AACGCAGTGA AGCGAGCCTC AGATAATCTG GTGAAAGCAG CACAGAAGGC TGCAGCCTTT 
GAAGAGCAGG AGAATGAGAC AGTGGTGGTG AAAGAGAAGA TGGTTGGCGG CATTGCCCAG 
ATCATCGCAG CACAGGAAGA AATGCTTCGG AAGGAACGAG AGCTGGAAGA GGCGCGGAAG 
AAACTGGCCC AGATCCGGCA GCAGCAGTAC AAGTTTCTGC CTTCAGAGCT TCGAGATGAG 
CACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TLN1 ( NM_006289.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006280.3 Homo sapiens talin 1 (TLN1), mRNA.

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CloneID	OHu12730
Clone ID Related Accession (Same CDS sequence)	NM_006289.4 , NM_006289.3
Accession Version	NM_006289.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 7626bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-05
Organism	Homo sapiens(human)
Product	talin-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL133410.32 and AB028950.2. On Feb 10, 2009 this sequence version replaced NM_006289.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC042923.1, AB028950.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTTGCAC TTTCACTGAA GATCAGCATT GGGAATGTGG TGAAGACGAT GCAGTTTGAG 
CCGTCTACCA TGGTGTACGA CGCCTGCCGC ATCATTCGTG AGCGGATCCC AGAGGCCCCA 
GCTGGTCCTC CCAGCGACTT TGGGCTCTTT CTGTCAGATG ATGACCCCAA AAAGGGTATA 
TGGCTGGAGG CTGGGAAAGC TTTGGACTAC TACATGCTCC GAAATGGGGA CACTATGGAG 
TACAGGAAGA AACAGAGACC CCTGAAGATC CGTATGCTGG ATGGAACTGT GAAGACGATC 
ATGGTGGATG ACTCTAAGAC TGTCACTGAC ATGCTCATGA CCATCTGTGC CCGCATTGGC 
ATCACCAATC ATGATGAATA TTCATTGGTT CGAGAGCTGA TGGAAGAGAA AAAGGAGGAA 
ATAACAGGGA CCTTAAGAAA GGACAAGACA TTGCTGCGAG ATGAAAAGAA GATGGAGAAA 
CTAAAGCAGA AATTGCACAC AGATGATGAG TTGAACTGGC TGGACCATGG TCGGACACTG 
AGGGAGCAGG GTGTAGAGGA GCACGAGACG CTGCTGCTGC GGAGGAAGTT CTTTTACTCA 
GACCAGAATG TGGATTCCCG GGACCCTGTA CAGCTGAACC TCCTGTATGT GCAGGCACGA 
GATGACATCC TGAATGGCTC CCACCCTGTC TCCTTTGACA AGGCCTGTGA GTTTGCTGGC 
TTCCAATGCC AGATCCAGTT TGGGCCCCAC AATGAGCAGA AGCACAAGGC TGGCTTCCTT 
GACCTGAAGG ACTTCCTGCC CAAGGAGTAT GTGAAGCAGA AGGGAGAGCG TAAGATCTTC 
CAGGCACACA AGAATTGTGG GCAGATGAGT GAGATTGAGG CCAAGGTCCG CTACGTGAAG 
CTAGCCCGTT CTCTCAAGAC TTACGGTGTC TCCTTCTTCC TGGTGAAGGA AAAAATGAAA 
GGGAAGAACA AGCTAGTGCC CAGGCTTCTG GGCATCACCA AGGAGTGTGT GATGCGAGTG 
GATGAGAAGA CCAAGGAAGT GATCCAGGAG TGGAACCTCA CCAACATCAA ACGCTGGGCT 
GCGTCTCCCA AAAGCTTCAC CCTGGATTTT GGAGATTACC AAGATGGCTA TTACTCAGTA 
CAGACAACTG AAGGGGAGCA GATTGCACAG CTCATTGCCG GCTACATCGA TATCATCCTG 
AAGAAGAAAA AAAGCAAGGA TCACTTTGGG CTGGAAGGAG ATGAGGAGTC TACTATGCTG 
GAGGACTCAG TGTCCCCCAA AAAGTCAACA GTCCTGCAGC AGCAATACAA CCGGGTGGGG 
AAAGTGGAGC ATGGCTCTGT GGCCCTGCCT GCCATCATGC GCTCTGGAGC CTCTGGTCCT 
GAGAATTTCC AGGTGGGCAG CATGCCCCCT GCCCAGCAGC AGATTACCAG CGGCCAGATG 
CACCGAGGAC ACATGCCTCC TCTGACTTCA GCCCAGCAGG CACTCACTGG AACCATTAAC 
TCCAGCATGC AGGCCGTGCA GGCTGCCCAG GCCACCCTGG ATGACTTTGA CACTCTGCCG 
CCTCTTGGCC AGGATGCTGC CTCTAAGGCC TGGCGTAAAA ACAAGATGGA TGAATCAAAG 
CATGAGATCC ACTCTCAGGT AGATGCCATC ACAGCTGGTA CTGCGTCTGT GGTGAACCTG 
ACAGCAGGGG ACCCTGCTGA GACAGACTAT ACCGCAGTGG GCTGTGCAGT CACCACAATC 
TCCTCCAACC TGACGGAGAT GTCCCGTGGG GTGAAGCTGC TGGCTGCCTT GCTGGAGGAC 
GAAGGCGGCA GTGGTCGGCC CCTGTTGCAG GCAGCAAAGG GCCTTGCGGG AGCAGTGTCA 
GAACTGCTGC GCAGTGCCCA ACCAGCCAGT GCTGAGCCCC GTCAGAACCT GCTGCAAGCA 
GCTGGGAACG TGGGCCAGGC CAGTGGGGAG CTGTTGCAAC AAATTGGGGA AAGTGATACT 
GACCCCCACT TCCAGGATGC GCTAATGCAG CTCGCCAAAG CTGTGGCAAG TGCTGCAGCT 
GCCCTGGTCC TCAAGGCCAA GAGTGTGGCC CAGCGGACAG AGGACTCGGG ACTTCAGACC 
CAAGTTATTG CTGCAGCAAC ACAGTGTGCC CTATCCACTT CCCAACTAGT GGCCTGTACT 
AAGGTGGTGG CACCTACAAT CAGCTCACCT GTCTGCCAAG AGCAACTGGT GGAGGCTGGA 
CGACTGGTAG CCAAAGCCGT GGAGGGCTGT GTGTCTGCCT CCCAGGCAGC TACAGAGGAT 
GGGCAACTGT TGCGAGGGGT AGGAGCAGCA GCCACAGCTG TCACCCAGGC CCTAAATGAG 
CTGCTGCAGC ATGTGAAAGC CCATGCCACA GGGGCTGGGC CTGCTGGCCG TTATGACCAG 
GCTACTGACA CCATCCTAAC CGTCACTGAG AACATCTTTA GCTCCATGGG TGATGCTGGG 
GAGATGGTGC GACAGGCCCG CATCCTGGCC CAAGCCACAT CTGACCTGGT CAATGCCATC 
AAGGCTGATG CTGAGGGGGA AAGTGATCTG GAGAACTCCC GCAAGCTCTT AAGTGCTGCC 
AAGATCCTAG CTGATGCCAC AGCCAAGATG GTAGAGGCTG CCAAGGGAGC AGCTGCCCAC 
CCTGACAGTG AGGAGCAGCA GCAGCGGCTG CGGGAGGCAG CTGAGGGGCT GCGCATGGCC 
ACCAATGCAG CTGCGCAGAA TGCCATCAAG AAAAAGCTGG TGCAGCGCCT GGAGCATGCA 
GCCAAGCAGG CTGCAGCCTC AGCCACACAG ACCATCGCTG CAGCTCAGCA CGCAGCCTCT 
ACCCCCAAGG CCTCTGCCGG CCCCCAGCCC CTGCTGGTGC AGAGCTGCAA GGCAGTGGCA 
GAGCAGATTC CACTGCTGGT GCAGGGCGTC CGAGGAAGCC AAGCCCAGCC TGACAGCCCC 
AGCGCTCAGC TTGCCCTCAT TGCTGCCAGC CAGAGCTTCC TGCAGCCAGG TGGGAAGATG 
GTGGCAGCTG CAAAGGCCTC AGTGCCAACG ATTCAGGACC AGGCTTCAGC CATGCAGCTG 
AGTCAGTGTG CCAAGAACCT GGGCACCGCG CTGGCTGAAC TCCGGACGGC TGCCCAGAAG 
GCTCAGGAAG CATGTGGACC TTTGGAGATG GATTCTGCAC TGAGTGTGGT ACAGAATCTA 
GAGAAAGATC TACAGGAAGT GAAGGCAGCA GCTCGAGATG GCAAGCTTAA ACCCTTACCT 
GGGGAGACAA TGGAGAAGTG TACCCAGGAC CTGGGCAACA GCACCAAAGC CGTGAGCTCA 
GCCATCGCCC AGCTACTGGG AGAGGTTGCC CAGGGCAATG AGAATTATGC AGGTATTGCA 
GCTCGGGATG TGGCAGGTGG GCTGCGGTCA CTGGCCCAGG CCGCTAGGGG AGTCGCTGCA 
CTGACGTCAG ATCCTGCAGT GCAGGCCATT GTACTTGATA CGGCCAGTGA TGTGCTGGAC 
AAGGCCAGCA GCCTCATTGA GGAGGCGAAA AAGGCAGCTG GCCATCCAGG GGACCCTGAG 
AGCCAGCAGC GGCTTGCCCA GGTGGCTAAA GCAGTGACCC AGGCTCTGAA CCGCTGTGTC 
AGCTGCCTAC CTGGCCAGCG CGATGTGGAT AATGCCCTGA GGGCAGTTGG AGATGCCAGC 
AAGCGACTCC TGAGTGACTC GCTTCCTCCT AGCACTGGGA CATTTCAAGA AGCTCAGAGC 
CGGTTGAATG AAGCTGCTGC TGGGCTGAAT CAGGCAGCCA CAGAACTGGT GCAGGCCTCT 
CGGGGAACCC CTCAGGACCT GGCTCGAGCC TCAGGCCGAT TTGGACAGGA CTTCAGCACC 
TTCCTGGAAG CTGGTGTGGA GATGGCAGGC CAGGCTCCGA GCCAGGAGGA CCGAGCCCAA 
GTTGTGTCCA ACTTGAAGGG CATCTCCATG TCTTCAAGCA AACTTCTTCT GGCTGCCAAG 
GCCCTGTCCA CGGACCCTGC TGCCCCTAAC CTCAAGAGTC AGCTGGCTGC AGCTGCCAGG 
GCAGTAACTG ACAGCATCAA TCAGCTCATC ACTATGTGCA CCCAGCAGGC ACCCGGCCAG 
AAGGAGTGTG ATAACGCCCT GCGGGAATTG GAGACGGTCC GGGAACTCCT GGAGAACCCA 
GTCCAGCCCA TCAATGACAT GTCCTACTTT GGTTGCCTGG ACAGTGTAAT GGAGAACTCA 
AAGGTGCTGG GCGAGGCCAT GACTGGCATC TCCCAAAATG CCAAGAACGG AAACCTGCCA 
GAGTTTGGAG ATGCCATTTC CACAGCCTCA AAGGCACTTT GTGGCTTCAC CGAGGCAGCT 
GCACAGGCTG CATATCTGGT TGGTGTCTCT GACCCCAATA GCCAAGCTGG ACAGCAAGGG 
CTAGTGGAGC CCACACAGTT TGCCCGTGCA AACCAGGCAA TTCAGATGGC CTGCCAGAGT 
TTGGGAGAGC CTGGCTGTAC CCAGGCCCAG GTGCTCTCTG CAGCCACCAT TGTGGCTAAA 
CACACCTCTG CACTGTGTAA CAGCTGTCGC CTGGCTTCTG CCCGTACCAC CAATCCTACT 
GCCAAGCGCC AGTTTGTACA GTCAGCCAAG GAGGTGGCCA ACAGCACAGC TAATCTTGTC 
AAGACCATCA AGGCGCTAGA TGGGGCCTTC ACAGAGGAGA ACCGTGCCCA GTGCCGAGCA 
GCAACAGCCC CTCTGCTGGA GGCTGTGGAC AATCTGAGTG CCTTTGCGTC CAACCCTGAG 
TTCTCCAGCA TTCCTGCCCA GATCAGCCCT GAGGGTCGGG CTGCCATGGA GCCCATTGTG 
ATCTCTGCCA AGACAATGTT AGAGAGTGCC GGGGGACTCA TCCAGACAGC CCGGGCCCTC 
GCAGTCAATC CCCGGGACCC CCCGAGCTGG TCGGTGCTGG CCGGCCACTC CCGTACTGTC 
TCAGACTCCA TCAAGAAGCT AATTACAAGC ATGAGGGACA AGGCTCCAGG GCAGCTGGAG 
TGTGAAACGG CCATTGCAGC TCTGAACAGT TGTCTACGGG ACCTAGACCA GGCTTCCCTC 
GCTGCAGTCA GCCAGCAGCT TGCTCCCCGT GAGGGAATCT CTCAAGAGGC CTTGCACACT 
CAGATGCTCA CTGCAGTCCA AGAGATCTCC CATCTCATTG AGCCGCTGGC CAATGCTGCC 
CGGGCTGAAG CCTCCCAGCT GGGACACAAG GTGTCCCAGA TGGCGCAGTA CTTTGAGCCG 
CTCACCCTGG CTGCAGTGGG TGCTGCCTCC AAGACCCTGA GCCACCCGCA GCAGATGGCA 
CTCCTGGACC AGACTAAAAC ATTGGCAGAG TCTGCCCTGC AGTTGCTATA CACTGCCAAG 
GAGGCTGGTG GTAACCCAAA GCAAGCAGCT CACACCCAGG AAGCCCTGGA GGAGGCTGTG 
CAGATGATGA CCGAGGCCGT AGAGGACCTG ACAACAACCC TCAACGAGGC AGCCAGTGCT 
GCTGGGGTCG TGGGTGGCAT GGTGGACTCC ATCACCCAGG CCATCAACCA GCTAGATGAA 
GGACCAATGG GTGAACCAGA AGGTTCCTTC GTGGATTACC AAACAACTAT GGTGCGGACA 
GCCAAGGCCA TTGCAGTGAC CGTTCAGGAG ATGGTTACCA AGTCAAACAC CAGCCCAGAG 
GAGCTGGGCC CTCTTGCTAA CCAGCTGACC AGTGACTATG GCCGTCTGGC CTCGGAGGCC 
AAGCCTGCAG CGGTGGCTGC TGAAAATGAA GAGATAGGTT CCCATATCAA ACACCGGGTA 
CAGGAGCTGG GCCATGGCTG TGCCGCTCTG GTCACCAAGG CAGGCGCCCT GCAGTGCAGC 
CCCAGTGATG CCTACACCAA GAAGGAGCTC ATAGAGTGTG CCCGGAGAGT CTCTGAGAAG 
GTCTCCCACG TCCTGGCTGC GCTCCAGGCT GGGAATCGTG GCACCCAGGC CTGCATCACA 
GCAGCCAGCG CTGTGTCTGG TATCATTGCT GACCTCGACA CCACCATCAT GTTCGCCACT 
GCTGGCACGC TCAATCGTGA GGGTACTGAA ACTTTCGCTG ACCACCGGGA GGGCATCCTG 
AAGACTGCGA AGGTGCTGGT GGAGGACACC AAGGTCCTGG TGCAAAACGC AGCTGGGAGC 
CAGGAGAAGT TGGCGCAGGC TGCCCAGTCC TCCGTGGCGA CCATCACCCG CCTCGCTGAT 
GTGGTCAAGC TGGGTGCAGC CAGCCTGGGA GCTGAGGACC CTGAGACCCA GGTGGTACTA 
ATCAACGCAG TGAAAGATGT AGCCAAAGCC CTGGGAGACC TCATCAGTGC AACGAAGGCT 
GCAGCTGGCA AAGTTGGAGA TGACCCTGCT GTGTGGCAGC TAAAGAACTC TGCCAAGGTG 
ATGGTGACCA ATGTGACATC ATTGCTTAAG ACAGTAAAAG CCGTGGAAGA TGAGGCCACC 
AAAGGCACTC GGGCCCTGGA GGCAACCACA GAACACATAC GGCAGGAGCT GGCGGTTTTC 
TGTTCCCCAG AGCCACCTGC CAAGACCTCT ACCCCAGAAG ACTTCATCCG AATGACCAAG 
GGTATCACCA TGGCAACCGC CAAGGCCGTT GCTGCTGGCA ATTCCTGTCG CCAGGAAGAT 
GTCATTGCCA CAGCCAATCT GAGCCGCCGT GCTATTGCAG ATATGCTTCG GGCTTGCAAG 
GAAGCAGCTT ACCACCCAGA AGTGGCCCCT GATGTGCGGC TTCGAGCCCT GCACTATGGC 
CGGGAGTGTG CCAATGGCTA CCTGGAACTG CTGGACCATG TACTGCTGAC CCTGCAGAAG 
CCAAGCCCAG AACTGAAGCA GCAGTTGACA GGACATTCAA AGCGTGTGGC TGGTTCCGTC 
ACTGAGCTCA TCCAGGCTGC TGAAGCCATG AAGGGAACAG AATGGGTAGA CCCAGAGGAC 
CCCACAGTCA TTGCTGAGAA TGAGCTCCTG GGAGCTGCAG CCGCCATTGA GGCTGCAGCC 
AAAAAGCTAG AGCAGCTGAA GCCCCGGGCC AAACCCAAGG AGGCAGATGA GTCCTTGAAC 
TTTGAGGAGC AGATACTAGA AGCTGCCAAG TCCATTGCAG CAGCCACCAG TGCACTGGTA 
AAGGCTGCGT CGGCTGCCCA GAGAGAACTA GTGGCCCAAG GGAAGGTGGG TGCCATTCCA 
GCCAATGCAC TGGACGATGG GCAGTGGTCC CAGGGCCTCA TTTCTGCTGC CCGGATGGTG 
GCTGCGGCCA CCAACAATCT GTGTGAGGCA GCCAATGCAG CTGTACAAGG CCATGCCAGC 
CAGGAGAAGC TCATCTCATC AGCCAAGCAG GTAGCTGCCT CCACAGCCCA GCTCCTTGTG 
GCCTGCAAGG TCAAGGCTGA CCAGGACTCG GAGGCAATGA AACGACTTCA GGCTGCTGGC 
AACGCAGTGA AGCGAGCCTC AGATAATCTG GTGAAAGCAG CACAGAAGGC TGCAGCCTTT 
GAAGAGCAGG AGAATGAGAC AGTGGTGGTG AAAGAGAAGA TGGTTGGCGG CATTGCCCAG 
ATCATCGCAG CACAGGAAGA AATGCTTCGG AAGGAACGAG AGCTGGAAGA GGCGCGGAAG 
AAACTGGCCC AGATCCGGCA GCAGCAGTAC AAGTTTCTGC CTTCAGAGCT TCGAGATGAG 
CACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006280.3
CDS	355..7980
Translation	MVALSLKISIGNVVKTMQFEPSTMVYDACRIIRERIPEAPAGPPSDFGLFLSDDDPKKGIWLEAGKALDYYMLRNGDTMEYRKKQRPLKIRMLDGTVKTIMVDDSKTVTDMLMTICARIGITNHDEYSLVRELMEEKKEEITGTLRKDKTLLRDEKKMEKLKQKLHTDDELNWLDHGRTLREQGVEEHETLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPVSFDKACEFAGFQCQIQFGPHNEQKHKAGFLDLKDFLPKEYVKQKGERKIFQAHKNCGQMSEIEAKVRYVKLARSLKTYGVSFFLVKEKMKGKNKLVPRLLGITKECVMRVDEKTKEVIQEWNLTNIKRWAASPKSFTLDFGDYQDGYYSVQTTEGEQIAQLIAGYIDIILKKKKSKDHFGLEGDEESTMLEDSVSPKKSTVLQQQYNRVGKVEHGSVALPAIMRSGASGPENFQVGSMPPAQQQITSGQMHRGHMPPLTSAQQALTGTINSSMQAVQAAQATLDDFDTLPPLGQDAASKAWRKNKMDESKHEIHSQVDAITAGTASVVNLTAGDPAETDYTAVGCAVTTISSNLTEMSRGVKLLAALLEDEGGSGRPLLQAAKGLAGAVSELLRSAQPASAEPRQNLLQAAGNVGQASGELLQQIGESDTDPHFQDALMQLAKAVASAAAALVLKAKSVAQRTEDSGLQTQVIAAATQCALSTSQLVACTKVVAPTISSPVCQEQLVEAGRLVAKAVEGCVSASQAATEDGQLLRGVGAAATAVTQALNELLQHVKAHATGAGPAGRYDQATDTILTVTENIFSSMGDAGEMVRQARILAQATSDLVNAIKADAEGESDLENSRKLLSAAKILADATAKMVEAAKGAAAHPDSEEQQQRLREAAEGLRMATNAAAQNAIKKKLVQRLEHAAKQAAASATQTIAAAQHAASTPKASAGPQPLLVQSCKAVAEQIPLLVQGVRGSQAQPDSPSAQLALIAASQSFLQPGGKMVAAAKASVPTIQDQASAMQLSQCAKNLGTALAELRTAAQKAQEACGPLEMDSALSVVQNLEKDLQEVKAAARDGKLKPLPGETMEKCTQDLGNSTKAVSSAIAQLLGEVAQGNENYAGIAARDVAGGLRSLAQAARGVAALTSDPAVQAIVLDTASDVLDKASSLIEEAKKAAGHPGDPESQQRLAQVAKAVTQALNRCVSCLPGQRDVDNALRAVGDASKRLLSDSLPPSTGTFQEAQSRLNEAAAGLNQAATELVQASRGTPQDLARASGRFGQDFSTFLEAGVEMAGQAPSQEDRAQVVSNLKGISMSSSKLLLAAKALSTDPAAPNLKSQLAAAARAVTDSINQLITMCTQQAPGQKECDNALRELETVRELLENPVQPINDMSYFGCLDSVMENSKVLGEAMTGISQNAKNGNLPEFGDAISTASKALCGFTEAAAQAAYLVGVSDPNSQAGQQGLVEPTQFARANQAIQMACQSLGEPGCTQAQVLSAATIVAKHTSALCNSCRLASARTTNPTAKRQFVQSAKEVANSTANLVKTIKALDGAFTEENRAQCRAATAPLLEAVDNLSAFASNPEFSSIPAQISPEGRAAMEPIVISAKTMLESAGGLIQTARALAVNPRDPPSWSVLAGHSRTVSDSIKKLITSMRDKAPGQLECETAIAALNSCLRDLDQASLAAVSQQLAPREGISQEALHTQMLTAVQEISHLIEPLANAARAEASQLGHKVSQMAQYFEPLTLAAVGAASKTLSHPQQMALLDQTKTLAESALQLLYTAKEAGGNPKQAAHTQEALEEAVQMMTEAVEDLTTTLNEAASAAGVVGGMVDSITQAINQLDEGPMGEPEGSFVDYQTTMVRTAKAIAVTVQEMVTKSNTSPEELGPLANQLTSDYGRLASEAKPAAVAAENEEIGSHIKHRVQELGHGCAALVTKAGALQCSPSDAYTKKELIECARRVSEKVSHVLAALQAGNRGTQACITAASAVSGIIADLDTTIMFATAGTLNREGTETFADHREGILKTAKVLVEDTKVLVQNAAGSQEKLAQAAQSSVATITRLADVVKLGAASLGAEDPETQVVLINAVKDVAKALGDLISATKAAAGKVGDDPAVWQLKNSAKVMVTNVTSLLKTVKAVEDEATKGTRALEATTEHIRQELAVFCSPEPPAKTSTPEDFIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRRAIADMLRACKEAAYHPEVAPDVRLRALHYGRECANGYLELLDHVLLTLQKPSPELKQQLTGHSKRVAGSVTELIQAAEAMKGTEWVDPEDPTVIAENELLGAAAAIEAAAKKLEQLKPRAKPKEADESLNFEEQILEAAKSIAAATSALVKAASAAQRELVAQGKVGAIPANALDDGQWSQGLISAARMVAAATNNLCEAANAAVQGHASQEKLISSAKQVAASTAQLLVACKVKADQDSEAMKRLQAAGNAVKRASDNLVKAAQKAAAFEEQENETVVVKEKMVGGIAQIIAAQEEMLRKERELEEARKKLAQIRQQQYKFLPSELRDEH

Target ORF information:

RefSeq Version	NM_006289.3
Organism	Homo sapiens(human)
Definition	Homo sapiens talin 1 (TLN1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006289.3

ORF Insert Sequence:

ATGGTTGCAC TTTCACTGAA GATCAGCATT GGGAATGTGG TGAAGACGAT GCAGTTTGAG 
CCGTCTACCA TGGTGTACGA CGCCTGCCGC ATCATTCGTG AGCGGATCCC AGAGGCCCCA 
GCTGGTCCTC CCAGCGACTT TGGGCTCTTT CTGTCAGATG ATGACCCCAA AAAGGGTATA 
TGGCTGGAGG CTGGGAAAGC TTTGGACTAC TACATGCTCC GAAATGGGGA CACTATGGAG 
TACAGGAAGA AACAGAGACC CCTGAAGATC CGTATGCTGG ATGGAACTGT GAAGACGATC 
ATGGTGGATG ACTCTAAGAC TGTCACTGAC ATGCTCATGA CCATCTGTGC CCGCATTGGC 
ATCACCAATC ATGATGAATA TTCATTGGTT CGAGAGCTGA TGGAAGAGAA AAAGGAGGAA 
ATAACAGGGA CCTTAAGAAA GGACAAGACA TTGCTGCGAG ATGAAAAGAA GATGGAGAAA 
CTAAAGCAGA AATTGCACAC AGATGATGAG TTGAACTGGC TGGACCATGG TCGGACACTG 
AGGGAGCAGG GTGTAGAGGA GCACGAGACG CTGCTGCTGC GGAGGAAGTT CTTTTACTCA 
GACCAGAATG TGGATTCCCG GGACCCTGTA CAGCTGAACC TCCTGTATGT GCAGGCACGA 
GATGACATCC TGAATGGCTC CCACCCTGTC TCCTTTGACA AGGCCTGTGA GTTTGCTGGC 
TTCCAATGCC AGATCCAGTT TGGGCCCCAC AATGAGCAGA AGCACAAGGC TGGCTTCCTT 
GACCTGAAGG ACTTCCTGCC CAAGGAGTAT GTGAAGCAGA AGGGAGAGCG TAAGATCTTC 
CAGGCACACA AGAATTGTGG GCAGATGAGT GAGATTGAGG CCAAGGTCCG CTACGTGAAG 
CTAGCCCGTT CTCTCAAGAC TTACGGTGTC TCCTTCTTCC TGGTGAAGGA AAAAATGAAA 
GGGAAGAACA AGCTAGTGCC CAGGCTTCTG GGCATCACCA AGGAGTGTGT GATGCGAGTG 
GATGAGAAGA CCAAGGAAGT GATCCAGGAG TGGAACCTCA CCAACATCAA ACGCTGGGCT 
GCGTCTCCCA AAAGCTTCAC CCTGGATTTT GGAGATTACC AAGATGGCTA TTACTCAGTA 
CAGACAACTG AAGGGGAGCA GATTGCACAG CTCATTGCCG GCTACATCGA TATCATCCTG 
AAGAAGAAAA AAAGCAAGGA TCACTTTGGG CTGGAAGGAG ATGAGGAGTC TACTATGCTG 
GAGGACTCAG TGTCCCCCAA AAAGTCAACA GTCCTGCAGC AGCAATACAA CCGGGTGGGG 
AAAGTGGAGC ATGGCTCTGT GGCCCTGCCT GCCATCATGC GCTCTGGAGC CTCTGGTCCT 
GAGAATTTCC AGGTGGGCAG CATGCCCCCT GCCCAGCAGC AGATTACCAG CGGCCAGATG 
CACCGAGGAC ACATGCCTCC TCTGACTTCA GCCCAGCAGG CACTCACTGG AACCATTAAC 
TCCAGCATGC AGGCCGTGCA GGCTGCCCAG GCCACCCTGG ATGACTTTGA CACTCTGCCG 
CCTCTTGGCC AGGATGCTGC CTCTAAGGCC TGGCGTAAAA ACAAGATGGA TGAATCAAAG 
CATGAGATCC ACTCTCAGGT AGATGCCATC ACAGCTGGTA CTGCGTCTGT GGTGAACCTG 
ACAGCAGGGG ACCCTGCTGA GACAGACTAT ACCGCAGTGG GCTGTGCAGT CACCACAATC 
TCCTCCAACC TGACGGAGAT GTCCCGTGGG GTGAAGCTGC TGGCTGCCTT GCTGGAGGAC 
GAAGGCGGCA GTGGTCGGCC CCTGTTGCAG GCAGCAAAGG GCCTTGCGGG AGCAGTGTCA 
GAACTGCTGC GCAGTGCCCA ACCAGCCAGT GCTGAGCCCC GTCAGAACCT GCTGCAAGCA 
GCTGGGAACG TGGGCCAGGC CAGTGGGGAG CTGTTGCAAC AAATTGGGGA AAGTGATACT 
GACCCCCACT TCCAGGATGC GCTAATGCAG CTCGCCAAAG CTGTGGCAAG TGCTGCAGCT 
GCCCTGGTCC TCAAGGCCAA GAGTGTGGCC CAGCGGACAG AGGACTCGGG ACTTCAGACC 
CAAGTTATTG CTGCAGCAAC ACAGTGTGCC CTATCCACTT CCCAACTAGT GGCCTGTACT 
AAGGTGGTGG CACCTACAAT CAGCTCACCT GTCTGCCAAG AGCAACTGGT GGAGGCTGGA 
CGACTGGTAG CCAAAGCCGT GGAGGGCTGT GTGTCTGCCT CCCAGGCAGC TACAGAGGAT 
GGGCAACTGT TGCGAGGGGT AGGAGCAGCA GCCACAGCTG TCACCCAGGC CCTAAATGAG 
CTGCTGCAGC ATGTGAAAGC CCATGCCACA GGGGCTGGGC CTGCTGGCCG TTATGACCAG 
GCTACTGACA CCATCCTAAC CGTCACTGAG AACATCTTTA GCTCCATGGG TGATGCTGGG 
GAGATGGTGC GACAGGCCCG CATCCTGGCC CAAGCCACAT CTGACCTGGT CAATGCCATC 
AAGGCTGATG CTGAGGGGGA AAGTGATCTG GAGAACTCCC GCAAGCTCTT AAGTGCTGCC 
AAGATCCTAG CTGATGCCAC AGCCAAGATG GTAGAGGCTG CCAAGGGAGC AGCTGCCCAC 
CCTGACAGTG AGGAGCAGCA GCAGCGGCTG CGGGAGGCAG CTGAGGGGCT GCGCATGGCC 
ACCAATGCAG CTGCGCAGAA TGCCATCAAG AAAAAGCTGG TGCAGCGCCT GGAGCATGCA 
GCCAAGCAGG CTGCAGCCTC AGCCACACAG ACCATCGCTG CAGCTCAGCA CGCAGCCTCT 
ACCCCCAAGG CCTCTGCCGG CCCCCAGCCC CTGCTGGTGC AGAGCTGCAA GGCAGTGGCA 
GAGCAGATTC CACTGCTGGT GCAGGGCGTC CGAGGAAGCC AAGCCCAGCC TGACAGCCCC 
AGCGCTCAGC TTGCCCTCAT TGCTGCCAGC CAGAGCTTCC TGCAGCCAGG TGGGAAGATG 
GTGGCAGCTG CAAAGGCCTC AGTGCCAACG ATTCAGGACC AGGCTTCAGC CATGCAGCTG 
AGTCAGTGTG CCAAGAACCT GGGCACCGCG CTGGCTGAAC TCCGGACGGC TGCCCAGAAG 
GCTCAGGAAG CATGTGGACC TTTGGAGATG GATTCTGCAC TGAGTGTGGT ACAGAATCTA 
GAGAAAGATC TACAGGAAGT GAAGGCAGCA GCTCGAGATG GCAAGCTTAA ACCCTTACCT 
GGGGAGACAA TGGAGAAGTG TACCCAGGAC CTGGGCAACA GCACCAAAGC CGTGAGCTCA 
GCCATCGCCC AGCTACTGGG AGAGGTTGCC CAGGGCAATG AGAATTATGC AGGTATTGCA 
GCTCGGGATG TGGCAGGTGG GCTGCGGTCA CTGGCCCAGG CCGCTAGGGG AGTCGCTGCA 
CTGACGTCAG ATCCTGCAGT GCAGGCCATT GTACTTGATA CGGCCAGTGA TGTGCTGGAC 
AAGGCCAGCA GCCTCATTGA GGAGGCGAAA AAGGCAGCTG GCCATCCAGG GGACCCTGAG 
AGCCAGCAGC GGCTTGCCCA GGTGGCTAAA GCAGTGACCC AGGCTCTGAA CCGCTGTGTC 
AGCTGCCTAC CTGGCCAGCG CGATGTGGAT AATGCCCTGA GGGCAGTTGG AGATGCCAGC 
AAGCGACTCC TGAGTGACTC GCTTCCTCCT AGCACTGGGA CATTTCAAGA AGCTCAGAGC 
CGGTTGAATG AAGCTGCTGC TGGGCTGAAT CAGGCAGCCA CAGAACTGGT GCAGGCCTCT 
CGGGGAACCC CTCAGGACCT GGCTCGAGCC TCAGGCCGAT TTGGACAGGA CTTCAGCACC 
TTCCTGGAAG CTGGTGTGGA GATGGCAGGC CAGGCTCCGA GCCAGGAGGA CCGAGCCCAA 
GTTGTGTCCA ACTTGAAGGG CATCTCCATG TCTTCAAGCA AACTTCTTCT GGCTGCCAAG 
GCCCTGTCCA CGGACCCTGC TGCCCCTAAC CTCAAGAGTC AGCTGGCTGC AGCTGCCAGG 
GCAGTAACTG ACAGCATCAA TCAGCTCATC ACTATGTGCA CCCAGCAGGC ACCCGGCCAG 
AAGGAGTGTG ATAACGCCCT GCGGGAATTG GAGACGGTCC GGGAACTCCT GGAGAACCCA 
GTCCAGCCCA TCAATGACAT GTCCTACTTT GGTTGCCTGG ACAGTGTAAT GGAGAACTCA 
AAGGTGCTGG GCGAGGCCAT GACTGGCATC TCCCAAAATG CCAAGAACGG AAACCTGCCA 
GAGTTTGGAG ATGCCATTTC CACAGCCTCA AAGGCACTTT GTGGCTTCAC CGAGGCAGCT 
GCACAGGCTG CATATCTGGT TGGTGTCTCT GACCCCAATA GCCAAGCTGG ACAGCAAGGG 
CTAGTGGAGC CCACACAGTT TGCCCGTGCA AACCAGGCAA TTCAGATGGC CTGCCAGAGT 
TTGGGAGAGC CTGGCTGTAC CCAGGCCCAG GTGCTCTCTG CAGCCACCAT TGTGGCTAAA 
CACACCTCTG CACTGTGTAA CAGCTGTCGC CTGGCTTCTG CCCGTACCAC CAATCCTACT 
GCCAAGCGCC AGTTTGTACA GTCAGCCAAG GAGGTGGCCA ACAGCACAGC TAATCTTGTC 
AAGACCATCA AGGCGCTAGA TGGGGCCTTC ACAGAGGAGA ACCGTGCCCA GTGCCGAGCA 
GCAACAGCCC CTCTGCTGGA GGCTGTGGAC AATCTGAGTG CCTTTGCGTC CAACCCTGAG 
TTCTCCAGCA TTCCTGCCCA GATCAGCCCT GAGGGTCGGG CTGCCATGGA GCCCATTGTG 
ATCTCTGCCA AGACAATGTT AGAGAGTGCC GGGGGACTCA TCCAGACAGC CCGGGCCCTC 
GCAGTCAATC CCCGGGACCC CCCGAGCTGG TCGGTGCTGG CCGGCCACTC CCGTACTGTC 
TCAGACTCCA TCAAGAAGCT AATTACAAGC ATGAGGGACA AGGCTCCAGG GCAGCTGGAG 
TGTGAAACGG CCATTGCAGC TCTGAACAGT TGTCTACGGG ACCTAGACCA GGCTTCCCTC 
GCTGCAGTCA GCCAGCAGCT TGCTCCCCGT GAGGGAATCT CTCAAGAGGC CTTGCACACT 
CAGATGCTCA CTGCAGTCCA AGAGATCTCC CATCTCATTG AGCCGCTGGC CAATGCTGCC 
CGGGCTGAAG CCTCCCAGCT GGGACACAAG GTGTCCCAGA TGGCGCAGTA CTTTGAGCCG 
CTCACCCTGG CTGCAGTGGG TGCTGCCTCC AAGACCCTGA GCCACCCGCA GCAGATGGCA 
CTCCTGGACC AGACTAAAAC ATTGGCAGAG TCTGCCCTGC AGTTGCTATA CACTGCCAAG 
GAGGCTGGTG GTAACCCAAA GCAAGCAGCT CACACCCAGG AAGCCCTGGA GGAGGCTGTG 
CAGATGATGA CCGAGGCCGT AGAGGACCTG ACAACAACCC TCAACGAGGC AGCCAGTGCT 
GCTGGGGTCG TGGGTGGCAT GGTGGACTCC ATCACCCAGG CCATCAACCA GCTAGATGAA 
GGACCAATGG GTGAACCAGA AGGTTCCTTC GTGGATTACC AAACAACTAT GGTGCGGACA 
GCCAAGGCCA TTGCAGTGAC CGTTCAGGAG ATGGTTACCA AGTCAAACAC CAGCCCAGAG 
GAGCTGGGCC CTCTTGCTAA CCAGCTGACC AGTGACTATG GCCGTCTGGC CTCGGAGGCC 
AAGCCTGCAG CGGTGGCTGC TGAAAATGAA GAGATAGGTT CCCATATCAA ACACCGGGTA 
CAGGAGCTGG GCCATGGCTG TGCCGCTCTG GTCACCAAGG CAGGCGCCCT GCAGTGCAGC 
CCCAGTGATG CCTACACCAA GAAGGAGCTC ATAGAGTGTG CCCGGAGAGT CTCTGAGAAG 
GTCTCCCACG TCCTGGCTGC GCTCCAGGCT GGGAATCGTG GCACCCAGGC CTGCATCACA 
GCAGCCAGCG CTGTGTCTGG TATCATTGCT GACCTCGACA CCACCATCAT GTTCGCCACT 
GCTGGCACGC TCAATCGTGA GGGTACTGAA ACTTTCGCTG ACCACCGGGA GGGCATCCTG 
AAGACTGCGA AGGTGCTGGT GGAGGACACC AAGGTCCTGG TGCAAAACGC AGCTGGGAGC 
CAGGAGAAGT TGGCGCAGGC TGCCCAGTCC TCCGTGGCGA CCATCACCCG CCTCGCTGAT 
GTGGTCAAGC TGGGTGCAGC CAGCCTGGGA GCTGAGGACC CTGAGACCCA GGTGGTACTA 
ATCAACGCAG TGAAAGATGT AGCCAAAGCC CTGGGAGACC TCATCAGTGC AACGAAGGCT 
GCAGCTGGCA AAGTTGGAGA TGACCCTGCT GTGTGGCAGC TAAAGAACTC TGCCAAGGTG 
ATGGTGACCA ATGTGACATC ATTGCTTAAG ACAGTAAAAG CCGTGGAAGA TGAGGCCACC 
AAAGGCACTC GGGCCCTGGA GGCAACCACA GAACACATAC GGCAGGAGCT GGCGGTTTTC 
TGTTCCCCAG AGCCACCTGC CAAGACCTCT ACCCCAGAAG ACTTCATCCG AATGACCAAG 
GGTATCACCA TGGCAACCGC CAAGGCCGTT GCTGCTGGCA ATTCCTGTCG CCAGGAAGAT 
GTCATTGCCA CAGCCAATCT GAGCCGCCGT GCTATTGCAG ATATGCTTCG GGCTTGCAAG 
GAAGCAGCTT ACCACCCAGA AGTGGCCCCT GATGTGCGGC TTCGAGCCCT GCACTATGGC 
CGGGAGTGTG CCAATGGCTA CCTGGAACTG CTGGACCATG TACTGCTGAC CCTGCAGAAG 
CCAAGCCCAG AACTGAAGCA GCAGTTGACA GGACATTCAA AGCGTGTGGC TGGTTCCGTC 
ACTGAGCTCA TCCAGGCTGC TGAAGCCATG AAGGGAACAG AATGGGTAGA CCCAGAGGAC 
CCCACAGTCA TTGCTGAGAA TGAGCTCCTG GGAGCTGCAG CCGCCATTGA GGCTGCAGCC 
AAAAAGCTAG AGCAGCTGAA GCCCCGGGCC AAACCCAAGG AGGCAGATGA GTCCTTGAAC 
TTTGAGGAGC AGATACTAGA AGCTGCCAAG TCCATTGCAG CAGCCACCAG TGCACTGGTA 
AAGGCTGCGT CGGCTGCCCA GAGAGAACTA GTGGCCCAAG GGAAGGTGGG TGCCATTCCA 
GCCAATGCAC TGGACGATGG GCAGTGGTCC CAGGGCCTCA TTTCTGCTGC CCGGATGGTG 
GCTGCGGCCA CCAACAATCT GTGTGAGGCA GCCAATGCAG CTGTACAAGG CCATGCCAGC 
CAGGAGAAGC TCATCTCATC AGCCAAGCAG GTAGCTGCCT CCACAGCCCA GCTCCTTGTG 
GCCTGCAAGG TCAAGGCTGA CCAGGACTCG GAGGCAATGA AACGACTTCA GGCTGCTGGC 
AACGCAGTGA AGCGAGCCTC AGATAATCTG GTGAAAGCAG CACAGAAGGC TGCAGCCTTT 
GAAGAGCAGG AGAATGAGAC AGTGGTGGTG AAAGAGAAGA TGGTTGGCGG CATTGCCCAG 
ATCATCGCAG CACAGGAAGA AATGCTTCGG AAGGAACGAG AGCTGGAAGA GGCGCGGAAG 
AAACTGGCCC AGATCCGGCA GCAGCAGTAC AAGTTTCTGC CTTCAGAGCT TCGAGATGAG 
CACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Integrin-bound talin head inhibits actin filament barbed end elongation.
The Journal of biological chemistry(2017 Dec)
Ciobanasu C,Wang H,Henriot V,Mathieu C,Fente A,Csillag S,Vigouroux C,Faivre B,Le Clainche C

Ecotopic viral integration site 1 (EVI1) transcriptionally targets talin1 (TLN1) and upregulates its expression in chronic myeloid leukemia.
Leukemia & lymphoma1-3(2017 Dec)
Halder A,Nayak KB,Chakraborty S

Multiplexing molecular tension sensors reveals piconewton force gradient across talin-1.
Nature methods14(11)1090-1096(2017 Nov)
Ringer P,Wei?l A,Cost AL,Freikamp A,Sabass B,Mehlich A,Tramier M,Rief M,Grashoff C

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TLN1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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