TLL2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TLL2
Entrez Gene ID	7093
Full Name	tolloid like 2
General protein information	Preferred Names tolloid like 2 Names tolloid-like protein 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10q24.1
Summary	This gene encodes an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin family. Unlike other family members, a similar protein in mice does not cleave procollagen C-propeptides or chordin. [provided by RefSeq, Jul 2008].
Disorder MIM:	606743

mRNA and Protein(s)

mRNA	Protein	Name
NM_012465.3	NP_036597.1	tolloid-like protein 2 precursor
NM_012465.4	NP_036597.1	tolloid-like protein 2 precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Tll2	NP_001178827.1
Mus musculus (house mouse)	Tll2	NP_036034.1
Canis lupus familiaris (dog)	TLL2	XP_543945.3
Bos taurus (cattle)	TLL2	XP_002698454.1
Homo sapiens (human)	TLL2	NP_036597.1
	TLL2	XP_001093659.2
Pan troglodytes (chimpanzee)	TLL2	XP_507953.3

Gene Ontology
Bibliography

Related articles in PubMed

Genetic variants in the metzincin metallopeptidase family genes predict melanoma survival.
Xu Y, Wang Y, Liu H, Shi Q, Zhu D, Amos CI, Fang S, Lee JE, Hyslop T, Li X, Han J, Wei Q
Molecular carcinogenesis57(1)22-31(2018 Jan)

Cross-species genetics converge to TLL2 for mouse avoidance behavior and human bipolar disorder.
de Mooij-van Malsen JG, van Lith HA, Laarakker MC, Brandys MK, Oppelaar H, Collier DA, Olivier B, Breen G, Kas MJ
Genes, brain, and behavior12(6)653-7(2013 Aug)

Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases.
Mac Sweeney A, Gil-Parrado S, Vinzenz D, Bernardi A, Hein A, Bodendorf U, Erbel P, Logel C, Gerhartz B
Journal of molecular biology384(1)228-39(2008 Dec)

Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.
Lesch KP, Timmesfeld N, Renner TJ, Halperin R, R?ser C, Nguyen TT, Craig DW, Romanos J, Heine M, Meyer J, Freitag C, Warnke A, Romanos M, Sch?fer H, Walitza S, Reif A, Stephan DA, Jacob C
Journal of neural transmission (Vienna, Austria : 1996)115(11)1573-85(2008 Nov)

A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vri?ze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A
American journal of human genetics78(1)78-88(2006 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Findings suggest that these MMP16 rs10090371, ADAMTS3 rs788935, TLL2 rs10882807 and MMP9 rs3918251 may be promising prognostic biomarkers for cutaneous melanoma specific survival (CMSS).
Title: Genetic variants in the metzincin metallopeptidase family genes predict melanoma survival.

By means of a cross-species comparative genetic strategy we describe an association for TLL2 with bipolar disorder.
Title: Cross-species genetics converge to TLL2 for mouse avoidance behavior and human bipolar disorder.

The crystal structures of the protease domains of human BMP-1 and the closely related Tolloid-like protease 1 (TLL-1), are reported.
Title: Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases.

Observational study of gene-disease association. (HuGE Navigator)
Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.

The following TLL2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TLL2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu12189	NM_012465.4 Latest version!	Homo sapiens tolloid like 2 (TLL2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$399.50-$559.30 $799.00
View Old Accession Versions >>
OHu12189	NM_012465.3	Homo sapiens tolloid like 2 (TLL2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$399.50-$559.30 $799.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TLL2 ( NM_012465.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_036597.1 Homo sapiens tolloid like 2 (TLL2), mRNA.

Price & Availability↑

CloneID	OHu12189
Clone ID Related Accession (Same CDS sequence)	NM_012465.3 , NM_012465.4
Accession Version	NM_012465.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3048bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-28
Organism	Homo sapiens(human)
Product	tolloid-like protein 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA716349.1, AB023149.2, BC112341.1, AL136181.13 and AW452288.1. On May 13, 2010 this sequence version replaced NM_012465.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AB023149.2, BC112341.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGCCCCGGG CGACTGCACT TGGGGCCCTG GTGTCACTGC TGCTGCTGCT GCCGCTGCCT 
CGCGGCGCCG GGGGACTCGG GGAGCGCCCG GACGCCACCG CAGACTACTC AGAGCTGGAC 
GGCGAGGAGG GCACGGAGCA GCAGCTGGAG CATTACCACG ACCCTTGCAA AGCCGCTGTC 
TTTTGGGGAG ACATTGCCTT AGATGAAGAT GACTTGAAGC TGTTTCACAT TGACAAAGCC 
AGAGACTGGA CCAAGCAGAC AGTGGGGGCA ACAGGACACA GCACAGGTGG GCTTGAAGAG 
CAGGCATCTG AGAGCAGCCC AGACACCACA GCCATGGACA CTGGCACCAA GGAAGCTGGA 
AAGGATGGCC GGGAGAATAC CACACTCCTG CACAGCCCTG GGACCTTGCA TGCCGCAGCC 
AAGACCTTCT CTCCCCGGGT CCGAAGAGCC ACAACCTCAA GGACAGAGAG GATATGGCCT 
GGAGGAGTCA TCCCCTACGT CATTGGAGGG AACTTCACTG GGAGCCAGAG GGCCATTTTT 
AAGCAGGCCA TGAGACACTG GGAGAAGCAC ACCTGTGTGA CCTTCATAGA AAGGACGGAT 
GAGGAAAGCT TTATTGTATT CAGTTACAGA ACCTGTGGCT GTTGCTCCTA TGTTGGGCGC 
CGAGGAGGAG GCCCACAGGC CATATCCATT GGGAAGAACT GTGACAAGTT TGGCATTGTG 
GCTCACGAGC TGGGCCATGT GGTTGGGTTT TGGCATGAAC ACACCCGGCC AGACAGAGAC 
CAACATGTCA CCATCATCAG GGAAAACATC CAGCCAGGTC AGGAGTATAA TTTCTTAAAA 
ATGGAAGCTG GGGAAGTGAG CTCTCTGGGA GAGACATACG ACTTTGACAG CATCATGCAC 
TACGCCCGGA ACACCTTCTC AAGAGGAGTT TTCTTAGACA CCATCCTTCC CCGTCAAGAT 
GACAATGGCG TCAGGCCAAC CATTGGCCAG CGCGTGCGGC TCAGTCAGGG AGACATAGCT 
CAAGCCCGGA AGCTGTACAA ATGCCCAGCG TGTGGGGAGA CCCTGCAGGA CACAACGGGA 
AACTTTTCTG CACCTGGTTT CCCAAATGGG TACCCATCTT ACTCCCACTG CGTCTGGAGG 
ATCTCGGTCA CCCCAGGGGA AAAGATCGTA TTAAACTTCA CATCCATGGA TTTGTTTAAA 
AGCCGACTGT GCTGGTATGA TTACGTGGAG GTCCGGGATG GTTACTGGAG AAAAGCCCCC 
CTTTTGGGCA GGTTTTGTGG CGATAAGATC CCGGAGCCCC TCGTCTCCAC GGACAGCCGG 
CTCTGGGTGG AGTTCCGCAG CAGCAGCAAC ATCTTGGGCA AGGGCTTCTT TGCAGCGTAC 
GAAGCTACCT GCGGGGGAGA CATGAACAAA GATGCCGGTC AGATTCAATC TCCCAACTAT 
CCGGATGACT ACAGACCTTC CAAGGAATGT GTCTGGAGGA TTACGGTTTC AGAGGGGTTT 
CACGTGGGAC TTACCTTCCA AGCTTTTGAG ATTGAAAGGC ACGACAGCTG TGCATATGAC 
TACCTGGAAG TCCGGGATGG CCCCACGGAA GAGAGTGCCC TGATCGGCCA CTTTTGTGGC 
TATGAGAAGC CGGAGGATGT GAAATCGAGC TCCAACAGAC TGTGGATGAA GTTTGTGTCC 
GATGGCTCTA TCAATAAAGC GGGCTTTGCA GCCAATTTTT TCAAGGAGGT GGATGAGTGT 
TCCTGGCCAG ATCACGGCGG GTGCGAGCAT CGCTGTGTGA ACACGCTGGG CAGCTACAAG 
TGTGCCTGTG ACCCTGGCTA CGAGCTGGCC GCCGATAAGA AGATGTGTGA AGTGGCCTGT 
GGCGGTTTCA TTACCAAGCT GAATGGAACC ATCACCAGCC CTGGGTGGCC GAAGGAGTAT 
CCCACAAACA AAAACTGTGT CTGGCAGGTG GTGGCCCCCG CTCAGTACCG GATCTCCCTT 
CAGTTTGAAG TGTTTGAACT GGAAGGCAAT GACGTCTGTA AGTACGACTT TGTAGAGGTG 
CGCAGCGGCC TGTCCCCCGA CGCCAAGCTG CACGGCAGGT TCTGCGGCTC TGAGACGCCG 
GAGGTCATCA CCTCGCAGAG CAACAACATG CGCGTGGAGT TCAAGTCCGA CAACACCGTC 
TCCAAGCGCG GCTTCAGGGC CCACTTCTTC TCAGATAAGG ACGAGTGTGC CAAGGACAAC 
GGCGGGTGTC AGCATGAGTG CGTCAACACC TTCGGGAGCT ACCTGTGCAG GTGCAGAAAC 
GGCTACTGGC TCCACGAGAA TGGGCATGAC TGCAAAGAGG CTGGCTGTGC ACACAAGATC 
AGCAGTGTGG AGGGGACCCT GGCGAGCCCC AACTGGCCTG ACAAATACCC CAGCCGGAGG 
GAGTGTACCT GGAACATCTC TTCGACTGCA GGCCACAGAG TGAAACTCAC CTTTAATGAG 
TTTGAGATCG AGCAGCACCA GGAATGTGCC TATGACCACC TGGAAATGTA TGACGGGCCG 
GACAGCCTGG CCCCCATTCT GGGCCGTTTC TGCGGCAGCA AGAAACCAGA CCCCACGGTG 
GCTTCCGGCA GCAGTATGTT TCTCAGGTTT TATTCGGATG CCTCAGTGCA GAGGAAAGGC 
TTCCAGGCAG TGCACAGCAC AGAGTGCGGG GGCAGGCTGA AGGCTGAAGT GCAGACCAAA 
GAGCTCTATT CCCACGCCCA GTTTGGGGAC AACAACTACC CGAGCGAGGC CCGCTGTGAC 
TGGGTGATCG TGGCAGAGGA CGGCTACGGC GTGGAGCTGA CATTCCGGAC CTTTGAGGTT 
GAGGAGGAGG CCGACTGCGG CTACGACTAC ATGGAAGCCT ACGACGGCTA CGACAGCTCA 
GCGCCCAGGC TCGGCCGCTT CTGTGGCTCT GGGCCATTAG AAGAAATCTA CTCTGCAGGT 
GATTCCCTGA TGATTCGATT CCGCACAGAT GACACCATCA ACAAGAAAGG CTTTCATGCC 
CGATACACCA GCACCAAGTT CCAGGATGCC CTGCACATGA AGAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036597.1
CDS	242..3289
Translation	MPRATALGALVSLLLLLPLPRGAGGLGERPDATADYSELDGEEGTEQQLEHYHDPCKAAVFWGDIALDEDDLKLFHIDKARDWTKQTVGATGHSTGGLEEQASESSPDTTAMDTGTKEAGKDGRENTTLLHSPGTLHAAAKTFSPRVRRATTSRTERIWPGGVIPYVIGGNFTGSQRAIFKQAMRHWEKHTCVTFIERTDEESFIVFSYRTCGCCSYVGRRGGGPQAISIGKNCDKFGIVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQEYNFLKMEAGEVSSLGETYDFDSIMHYARNTFSRGVFLDTILPRQDDNGVRPTIGQRVRLSQGDIAQARKLYKCPACGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYDYVEVRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYEATCGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYDYLEVRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDECSWPDHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKLNGTITSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVEVRSGLSPDAKLHGRFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGCQHECVNTFGSYLCRCRNGYWLHENGHDCKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQHQECAYDHLEMYDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKGFQAVHSTECGGRLKAEVQTKELYSHAQFGDNNYPSEARCDWVIVAEDGYGVELTFRTFEVEEEADCGYDYMEAYDGYDSSAPRLGRFCGSGPLEEIYSAGDSLMIRFRTDDTINKKGFHARYTSTKFQDALHMKK

Target ORF information:

RefSeq Version	NM_012465.3
Organism	Homo sapiens(human)
Definition	Homo sapiens tolloid like 2 (TLL2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012465.3

ORF Insert Sequence:

ATGCCCCGGG CGACTGCACT TGGGGCCCTG GTGTCACTGC TGCTGCTGCT GCCGCTGCCT 
CGCGGCGCCG GGGGACTCGG GGAGCGCCCG GACGCCACCG CAGACTACTC AGAGCTGGAC 
GGCGAGGAGG GCACGGAGCA GCAGCTGGAG CATTACCACG ACCCTTGCAA AGCCGCTGTC 
TTTTGGGGAG ACATTGCCTT AGATGAAGAT GACTTGAAGC TGTTTCACAT TGACAAAGCC 
AGAGACTGGA CCAAGCAGAC AGTGGGGGCA ACAGGACACA GCACAGGTGG GCTTGAAGAG 
CAGGCATCTG AGAGCAGCCC AGACACCACA GCCATGGACA CTGGCACCAA GGAAGCTGGA 
AAGGATGGCC GGGAGAATAC CACACTCCTG CACAGCCCTG GGACCTTGCA TGCCGCAGCC 
AAGACCTTCT CTCCCCGGGT CCGAAGAGCC ACAACCTCAA GGACAGAGAG GATATGGCCT 
GGAGGAGTCA TCCCCTACGT CATTGGAGGG AACTTCACTG GGAGCCAGAG GGCCATTTTT 
AAGCAGGCCA TGAGACACTG GGAGAAGCAC ACCTGTGTGA CCTTCATAGA AAGGACGGAT 
GAGGAAAGCT TTATTGTATT CAGTTACAGA ACCTGTGGCT GTTGCTCCTA TGTTGGGCGC 
CGAGGAGGAG GCCCACAGGC CATATCCATT GGGAAGAACT GTGACAAGTT TGGCATTGTG 
GCTCACGAGC TGGGCCATGT GGTTGGGTTT TGGCATGAAC ACACCCGGCC AGACAGAGAC 
CAACATGTCA CCATCATCAG GGAAAACATC CAGCCAGGTC AGGAGTATAA TTTCTTAAAA 
ATGGAAGCTG GGGAAGTGAG CTCTCTGGGA GAGACATACG ACTTTGACAG CATCATGCAC 
TACGCCCGGA ACACCTTCTC AAGAGGAGTT TTCTTAGACA CCATCCTTCC CCGTCAAGAT 
GACAATGGCG TCAGGCCAAC CATTGGCCAG CGCGTGCGGC TCAGTCAGGG AGACATAGCT 
CAAGCCCGGA AGCTGTACAA ATGCCCAGCG TGTGGGGAGA CCCTGCAGGA CACAACGGGA 
AACTTTTCTG CACCTGGTTT CCCAAATGGG TACCCATCTT ACTCCCACTG CGTCTGGAGG 
ATCTCGGTCA CCCCAGGGGA AAAGATCGTA TTAAACTTCA CATCCATGGA TTTGTTTAAA 
AGCCGACTGT GCTGGTATGA TTACGTGGAG GTCCGGGATG GTTACTGGAG AAAAGCCCCC 
CTTTTGGGCA GGTTTTGTGG CGATAAGATC CCGGAGCCCC TCGTCTCCAC GGACAGCCGG 
CTCTGGGTGG AGTTCCGCAG CAGCAGCAAC ATCTTGGGCA AGGGCTTCTT TGCAGCGTAC 
GAAGCTACCT GCGGGGGAGA CATGAACAAA GATGCCGGTC AGATTCAATC TCCCAACTAT 
CCGGATGACT ACAGACCTTC CAAGGAATGT GTCTGGAGGA TTACGGTTTC AGAGGGGTTT 
CACGTGGGAC TTACCTTCCA AGCTTTTGAG ATTGAAAGGC ACGACAGCTG TGCATATGAC 
TACCTGGAAG TCCGGGATGG CCCCACGGAA GAGAGTGCCC TGATCGGCCA CTTTTGTGGC 
TATGAGAAGC CGGAGGATGT GAAATCGAGC TCCAACAGAC TGTGGATGAA GTTTGTGTCC 
GATGGCTCTA TCAATAAAGC GGGCTTTGCA GCCAATTTTT TCAAGGAGGT GGATGAGTGT 
TCCTGGCCAG ATCACGGCGG GTGCGAGCAT CGCTGTGTGA ACACGCTGGG CAGCTACAAG 
TGTGCCTGTG ACCCTGGCTA CGAGCTGGCC GCCGATAAGA AGATGTGTGA AGTGGCCTGT 
GGCGGTTTCA TTACCAAGCT GAATGGAACC ATCACCAGCC CTGGGTGGCC GAAGGAGTAT 
CCCACAAACA AAAACTGTGT CTGGCAGGTG GTGGCCCCCG CTCAGTACCG GATCTCCCTT 
CAGTTTGAAG TGTTTGAACT GGAAGGCAAT GACGTCTGTA AGTACGACTT TGTAGAGGTG 
CGCAGCGGCC TGTCCCCCGA CGCCAAGCTG CACGGCAGGT TCTGCGGCTC TGAGACGCCG 
GAGGTCATCA CCTCGCAGAG CAACAACATG CGCGTGGAGT TCAAGTCCGA CAACACCGTC 
TCCAAGCGCG GCTTCAGGGC CCACTTCTTC TCAGATAAGG ACGAGTGTGC CAAGGACAAC 
GGCGGGTGTC AGCATGAGTG CGTCAACACC TTCGGGAGCT ACCTGTGCAG GTGCAGAAAC 
GGCTACTGGC TCCACGAGAA TGGGCATGAC TGCAAAGAGG CTGGCTGTGC ACACAAGATC 
AGCAGTGTGG AGGGGACCCT GGCGAGCCCC AACTGGCCTG ACAAATACCC CAGCCGGAGG 
GAGTGTACCT GGAACATCTC TTCGACTGCA GGCCACAGAG TGAAACTCAC CTTTAATGAG 
TTTGAGATCG AGCAGCACCA GGAATGTGCC TATGACCACC TGGAAATGTA TGACGGGCCG 
GACAGCCTGG CCCCCATTCT GGGCCGTTTC TGCGGCAGCA AGAAACCAGA CCCCACGGTG 
GCTTCCGGCA GCAGTATGTT TCTCAGGTTT TATTCGGATG CCTCAGTGCA GAGGAAAGGC 
TTCCAGGCAG TGCACAGCAC AGAGTGCGGG GGCAGGCTGA AGGCTGAAGT GCAGACCAAA 
GAGCTCTATT CCCACGCCCA GTTTGGGGAC AACAACTACC CGAGCGAGGC CCGCTGTGAC 
TGGGTGATCG TGGCAGAGGA CGGCTACGGC GTGGAGCTGA CATTCCGGAC CTTTGAGGTT 
GAGGAGGAGG CCGACTGCGG CTACGACTAC ATGGAAGCCT ACGACGGCTA CGACAGCTCA 
GCGCCCAGGC TCGGCCGCTT CTGTGGCTCT GGGCCATTAG AAGAAATCTA CTCTGCAGGT 
GATTCCCTGA TGATTCGATT CCGCACAGAT GACACCATCA ACAAGAAAGG CTTTCATGCC 
CGATACACCA GCACCAAGTT CCAGGATGCC CTGCACATGA AGAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TLL2 ( NM_012465.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_036597.1 Homo sapiens tolloid like 2 (TLL2), mRNA.

Price & Availability↑

CloneID	OHu12189
Clone ID Related Accession (Same CDS sequence)	NM_012465.3 , NM_012465.4
Accession Version	NM_012465.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3048bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-06
Organism	Homo sapiens(human)
Product	tolloid-like protein 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA716349.1, AB023149.2, BC112341.1, AL136181.13 and AW452288.1. On Nov 23, 2018 this sequence version replaced NM_012465.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AB023149.2, BC112341.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000357947.4/ ENSP00000350630.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCCCGGG CGACTGCACT TGGGGCCCTG GTGTCACTGC TGCTGCTGCT GCCGCTGCCT 
CGCGGCGCCG GGGGACTCGG GGAGCGCCCG GACGCCACCG CAGACTACTC AGAGCTGGAC 
GGCGAGGAGG GCACGGAGCA GCAGCTGGAG CATTACCACG ACCCTTGCAA AGCCGCTGTC 
TTTTGGGGAG ACATTGCCTT AGATGAAGAT GACTTGAAGC TGTTTCACAT TGACAAAGCC 
AGAGACTGGA CCAAGCAGAC AGTGGGGGCA ACAGGACACA GCACAGGTGG GCTTGAAGAG 
CAGGCATCTG AGAGCAGCCC AGACACCACA GCCATGGACA CTGGCACCAA GGAAGCTGGA 
AAGGATGGCC GGGAGAATAC CACACTCCTG CACAGCCCTG GGACCTTGCA TGCCGCAGCC 
AAGACCTTCT CTCCCCGGGT CCGAAGAGCC ACAACCTCAA GGACAGAGAG GATATGGCCT 
GGAGGAGTCA TCCCCTACGT CATTGGAGGG AACTTCACTG GGAGCCAGAG GGCCATTTTT 
AAGCAGGCCA TGAGACACTG GGAGAAGCAC ACCTGTGTGA CCTTCATAGA AAGGACGGAT 
GAGGAAAGCT TTATTGTATT CAGTTACAGA ACCTGTGGCT GTTGCTCCTA TGTTGGGCGC 
CGAGGAGGAG GCCCACAGGC CATATCCATT GGGAAGAACT GTGACAAGTT TGGCATTGTG 
GCTCACGAGC TGGGCCATGT GGTTGGGTTT TGGCATGAAC ACACCCGGCC AGACAGAGAC 
CAACATGTCA CCATCATCAG GGAAAACATC CAGCCAGGTC AGGAGTATAA TTTCTTAAAA 
ATGGAAGCTG GGGAAGTGAG CTCTCTGGGA GAGACATACG ACTTTGACAG CATCATGCAC 
TACGCCCGGA ACACCTTCTC AAGAGGAGTT TTCTTAGACA CCATCCTTCC CCGTCAAGAT 
GACAATGGCG TCAGGCCAAC CATTGGCCAG CGCGTGCGGC TCAGTCAGGG AGACATAGCT 
CAAGCCCGGA AGCTGTACAA ATGCCCAGCG TGTGGGGAGA CCCTGCAGGA CACAACGGGA 
AACTTTTCTG CACCTGGTTT CCCAAATGGG TACCCATCTT ACTCCCACTG CGTCTGGAGG 
ATCTCGGTCA CCCCAGGGGA AAAGATCGTA TTAAACTTCA CATCCATGGA TTTGTTTAAA 
AGCCGACTGT GCTGGTATGA TTACGTGGAG GTCCGGGATG GTTACTGGAG AAAAGCCCCC 
CTTTTGGGCA GGTTTTGTGG CGATAAGATC CCGGAGCCCC TCGTCTCCAC GGACAGCCGG 
CTCTGGGTGG AGTTCCGCAG CAGCAGCAAC ATCTTGGGCA AGGGCTTCTT TGCAGCGTAC 
GAAGCTACCT GCGGGGGAGA CATGAACAAA GATGCCGGTC AGATTCAATC TCCCAACTAT 
CCGGATGACT ACAGACCTTC CAAGGAATGT GTCTGGAGGA TTACGGTTTC AGAGGGGTTT 
CACGTGGGAC TTACCTTCCA AGCTTTTGAG ATTGAAAGGC ACGACAGCTG TGCATATGAC 
TACCTGGAAG TCCGGGATGG CCCCACGGAA GAGAGTGCCC TGATCGGCCA CTTTTGTGGC 
TATGAGAAGC CGGAGGATGT GAAATCGAGC TCCAACAGAC TGTGGATGAA GTTTGTGTCC 
GATGGCTCTA TCAATAAAGC GGGCTTTGCA GCCAATTTTT TCAAGGAGGT GGATGAGTGT 
TCCTGGCCAG ATCACGGCGG GTGCGAGCAT CGCTGTGTGA ACACGCTGGG CAGCTACAAG 
TGTGCCTGTG ACCCTGGCTA CGAGCTGGCC GCCGATAAGA AGATGTGTGA AGTGGCCTGT 
GGCGGTTTCA TTACCAAGCT GAATGGAACC ATCACCAGCC CTGGGTGGCC GAAGGAGTAT 
CCCACAAACA AAAACTGTGT CTGGCAGGTG GTGGCCCCCG CTCAGTACCG GATCTCCCTT 
CAGTTTGAAG TGTTTGAACT GGAAGGCAAT GACGTCTGTA AGTACGACTT TGTAGAGGTG 
CGCAGCGGCC TGTCCCCCGA CGCCAAGCTG CACGGCAGGT TCTGCGGCTC TGAGACGCCG 
GAGGTCATCA CCTCGCAGAG CAACAACATG CGCGTGGAGT TCAAGTCCGA CAACACCGTC 
TCCAAGCGCG GCTTCAGGGC CCACTTCTTC TCAGATAAGG ACGAGTGTGC CAAGGACAAC 
GGCGGGTGTC AGCATGAGTG CGTCAACACC TTCGGGAGCT ACCTGTGCAG GTGCAGAAAC 
GGCTACTGGC TCCACGAGAA TGGGCATGAC TGCAAAGAGG CTGGCTGTGC ACACAAGATC 
AGCAGTGTGG AGGGGACCCT GGCGAGCCCC AACTGGCCTG ACAAATACCC CAGCCGGAGG 
GAGTGTACCT GGAACATCTC TTCGACTGCA GGCCACAGAG TGAAACTCAC CTTTAATGAG 
TTTGAGATCG AGCAGCACCA GGAATGTGCC TATGACCACC TGGAAATGTA TGACGGGCCG 
GACAGCCTGG CCCCCATTCT GGGCCGTTTC TGCGGCAGCA AGAAACCAGA CCCCACGGTG 
GCTTCCGGCA GCAGTATGTT TCTCAGGTTT TATTCGGATG CCTCAGTGCA GAGGAAAGGC 
TTCCAGGCAG TGCACAGCAC AGAGTGCGGG GGCAGGCTGA AGGCTGAAGT GCAGACCAAA 
GAGCTCTATT CCCACGCCCA GTTTGGGGAC AACAACTACC CGAGCGAGGC CCGCTGTGAC 
TGGGTGATCG TGGCAGAGGA CGGCTACGGC GTGGAGCTGA CATTCCGGAC CTTTGAGGTT 
GAGGAGGAGG CCGACTGCGG CTACGACTAC ATGGAAGCCT ACGACGGCTA CGACAGCTCA 
GCGCCCAGGC TCGGCCGCTT CTGTGGCTCT GGGCCATTAG AAGAAATCTA CTCTGCAGGT 
GATTCCCTGA TGATTCGATT CCGCACAGAT GACACCATCA ACAAGAAAGG CTTTCATGCC 
CGATACACCA GCACCAAGTT CCAGGATGCC CTGCACATGA AGAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036597.1
CDS	242..3289
Translation	MPRATALGALVSLLLLLPLPRGAGGLGERPDATADYSELDGEEGTEQQLEHYHDPCKAAVFWGDIALDEDDLKLFHIDKARDWTKQTVGATGHSTGGLEEQASESSPDTTAMDTGTKEAGKDGRENTTLLHSPGTLHAAAKTFSPRVRRATTSRTERIWPGGVIPYVIGGNFTGSQRAIFKQAMRHWEKHTCVTFIERTDEESFIVFSYRTCGCCSYVGRRGGGPQAISIGKNCDKFGIVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQEYNFLKMEAGEVSSLGETYDFDSIMHYARNTFSRGVFLDTILPRQDDNGVRPTIGQRVRLSQGDIAQARKLYKCPACGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYDYVEVRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYEATCGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYDYLEVRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDECSWPDHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKLNGTITSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVEVRSGLSPDAKLHGRFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGCQHECVNTFGSYLCRCRNGYWLHENGHDCKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQHQECAYDHLEMYDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKGFQAVHSTECGGRLKAEVQTKELYSHAQFGDNNYPSEARCDWVIVAEDGYGVELTFRTFEVEEEADCGYDYMEAYDGYDSSAPRLGRFCGSGPLEEIYSAGDSLMIRFRTDDTINKKGFHARYTSTKFQDALHMKK

Target ORF information:

RefSeq Version	NM_012465.4
Organism	Homo sapiens(human)
Definition	Homo sapiens tolloid like 2 (TLL2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012465.4

ORF Insert Sequence:

ATGCCCCGGG CGACTGCACT TGGGGCCCTG GTGTCACTGC TGCTGCTGCT GCCGCTGCCT 
CGCGGCGCCG GGGGACTCGG GGAGCGCCCG GACGCCACCG CAGACTACTC AGAGCTGGAC 
GGCGAGGAGG GCACGGAGCA GCAGCTGGAG CATTACCACG ACCCTTGCAA AGCCGCTGTC 
TTTTGGGGAG ACATTGCCTT AGATGAAGAT GACTTGAAGC TGTTTCACAT TGACAAAGCC 
AGAGACTGGA CCAAGCAGAC AGTGGGGGCA ACAGGACACA GCACAGGTGG GCTTGAAGAG 
CAGGCATCTG AGAGCAGCCC AGACACCACA GCCATGGACA CTGGCACCAA GGAAGCTGGA 
AAGGATGGCC GGGAGAATAC CACACTCCTG CACAGCCCTG GGACCTTGCA TGCCGCAGCC 
AAGACCTTCT CTCCCCGGGT CCGAAGAGCC ACAACCTCAA GGACAGAGAG GATATGGCCT 
GGAGGAGTCA TCCCCTACGT CATTGGAGGG AACTTCACTG GGAGCCAGAG GGCCATTTTT 
AAGCAGGCCA TGAGACACTG GGAGAAGCAC ACCTGTGTGA CCTTCATAGA AAGGACGGAT 
GAGGAAAGCT TTATTGTATT CAGTTACAGA ACCTGTGGCT GTTGCTCCTA TGTTGGGCGC 
CGAGGAGGAG GCCCACAGGC CATATCCATT GGGAAGAACT GTGACAAGTT TGGCATTGTG 
GCTCACGAGC TGGGCCATGT GGTTGGGTTT TGGCATGAAC ACACCCGGCC AGACAGAGAC 
CAACATGTCA CCATCATCAG GGAAAACATC CAGCCAGGTC AGGAGTATAA TTTCTTAAAA 
ATGGAAGCTG GGGAAGTGAG CTCTCTGGGA GAGACATACG ACTTTGACAG CATCATGCAC 
TACGCCCGGA ACACCTTCTC AAGAGGAGTT TTCTTAGACA CCATCCTTCC CCGTCAAGAT 
GACAATGGCG TCAGGCCAAC CATTGGCCAG CGCGTGCGGC TCAGTCAGGG AGACATAGCT 
CAAGCCCGGA AGCTGTACAA ATGCCCAGCG TGTGGGGAGA CCCTGCAGGA CACAACGGGA 
AACTTTTCTG CACCTGGTTT CCCAAATGGG TACCCATCTT ACTCCCACTG CGTCTGGAGG 
ATCTCGGTCA CCCCAGGGGA AAAGATCGTA TTAAACTTCA CATCCATGGA TTTGTTTAAA 
AGCCGACTGT GCTGGTATGA TTACGTGGAG GTCCGGGATG GTTACTGGAG AAAAGCCCCC 
CTTTTGGGCA GGTTTTGTGG CGATAAGATC CCGGAGCCCC TCGTCTCCAC GGACAGCCGG 
CTCTGGGTGG AGTTCCGCAG CAGCAGCAAC ATCTTGGGCA AGGGCTTCTT TGCAGCGTAC 
GAAGCTACCT GCGGGGGAGA CATGAACAAA GATGCCGGTC AGATTCAATC TCCCAACTAT 
CCGGATGACT ACAGACCTTC CAAGGAATGT GTCTGGAGGA TTACGGTTTC AGAGGGGTTT 
CACGTGGGAC TTACCTTCCA AGCTTTTGAG ATTGAAAGGC ACGACAGCTG TGCATATGAC 
TACCTGGAAG TCCGGGATGG CCCCACGGAA GAGAGTGCCC TGATCGGCCA CTTTTGTGGC 
TATGAGAAGC CGGAGGATGT GAAATCGAGC TCCAACAGAC TGTGGATGAA GTTTGTGTCC 
GATGGCTCTA TCAATAAAGC GGGCTTTGCA GCCAATTTTT TCAAGGAGGT GGATGAGTGT 
TCCTGGCCAG ATCACGGCGG GTGCGAGCAT CGCTGTGTGA ACACGCTGGG CAGCTACAAG 
TGTGCCTGTG ACCCTGGCTA CGAGCTGGCC GCCGATAAGA AGATGTGTGA AGTGGCCTGT 
GGCGGTTTCA TTACCAAGCT GAATGGAACC ATCACCAGCC CTGGGTGGCC GAAGGAGTAT 
CCCACAAACA AAAACTGTGT CTGGCAGGTG GTGGCCCCCG CTCAGTACCG GATCTCCCTT 
CAGTTTGAAG TGTTTGAACT GGAAGGCAAT GACGTCTGTA AGTACGACTT TGTAGAGGTG 
CGCAGCGGCC TGTCCCCCGA CGCCAAGCTG CACGGCAGGT TCTGCGGCTC TGAGACGCCG 
GAGGTCATCA CCTCGCAGAG CAACAACATG CGCGTGGAGT TCAAGTCCGA CAACACCGTC 
TCCAAGCGCG GCTTCAGGGC CCACTTCTTC TCAGATAAGG ACGAGTGTGC CAAGGACAAC 
GGCGGGTGTC AGCATGAGTG CGTCAACACC TTCGGGAGCT ACCTGTGCAG GTGCAGAAAC 
GGCTACTGGC TCCACGAGAA TGGGCATGAC TGCAAAGAGG CTGGCTGTGC ACACAAGATC 
AGCAGTGTGG AGGGGACCCT GGCGAGCCCC AACTGGCCTG ACAAATACCC CAGCCGGAGG 
GAGTGTACCT GGAACATCTC TTCGACTGCA GGCCACAGAG TGAAACTCAC CTTTAATGAG 
TTTGAGATCG AGCAGCACCA GGAATGTGCC TATGACCACC TGGAAATGTA TGACGGGCCG 
GACAGCCTGG CCCCCATTCT GGGCCGTTTC TGCGGCAGCA AGAAACCAGA CCCCACGGTG 
GCTTCCGGCA GCAGTATGTT TCTCAGGTTT TATTCGGATG CCTCAGTGCA GAGGAAAGGC 
TTCCAGGCAG TGCACAGCAC AGAGTGCGGG GGCAGGCTGA AGGCTGAAGT GCAGACCAAA 
GAGCTCTATT CCCACGCCCA GTTTGGGGAC AACAACTACC CGAGCGAGGC CCGCTGTGAC 
TGGGTGATCG TGGCAGAGGA CGGCTACGGC GTGGAGCTGA CATTCCGGAC CTTTGAGGTT 
GAGGAGGAGG CCGACTGCGG CTACGACTAC ATGGAAGCCT ACGACGGCTA CGACAGCTCA 
GCGCCCAGGC TCGGCCGCTT CTGTGGCTCT GGGCCATTAG AAGAAATCTA CTCTGCAGGT 
GATTCCCTGA TGATTCGATT CCGCACAGAT GACACCATCA ACAAGAAAGG CTTTCATGCC 
CGATACACCA GCACCAAGTT CCAGGATGCC CTGCACATGA AGAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genetic variants in the metzincin metallopeptidase family genes predict melanoma survival.
Molecular carcinogenesis57(1)22-31(2018 Jan)
Xu Y,Wang Y,Liu H,Shi Q,Zhu D,Amos CI,Fang S,Lee JE,Hyslop T,Li X,Han J,Wei Q

Cross-species genetics converge to TLL2 for mouse avoidance behavior and human bipolar disorder.
Genes, brain, and behavior12(6)653-7(2013 Aug)
de Mooij-van Malsen JG,van Lith HA,Laarakker MC,Brandys MK,Oppelaar H,Collier DA,Olivier B,Breen G,Kas MJ

Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases.
Journal of molecular biology384(1)228-39(2008 Dec)
Mac Sweeney A,Gil-Parrado S,Vinzenz D,Bernardi A,Hein A,Bodendorf U,Erbel P,Logel C,Gerhartz B

Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.
Journal of neural transmission (Vienna, Austria : 1996)115(11)1573-85(2008 Nov)
Lesch KP,Timmesfeld N,Renner TJ,Halperin R,R?ser C,Nguyen TT,Craig DW,Romanos J,Heine M,Meyer J,Freitag C,Warnke A,Romanos M,Sch?fer H,Walitza S,Reif A,Stephan DA,Jacob C

A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
American journal of human genetics78(1)78-88(2006 Jan)
Grupe A,Li Y,Rowland C,Nowotny P,Hinrichs AL,Smemo S,Kauwe JS,Maxwell TJ,Cherny S,Doil L,Tacey K,van Luchene R,Myers A,Wavrant-De Vri?ze F,Kaleem M,Hollingworth P,Jehu L,Foy C,Archer N,Hamilton G,Holmans P,Morris CM,Catanese J,Sninsky J,White TJ,Powell J,Hardy J,O'Donovan M,Lovestone S,Jones L,Morris JC,Thal L,Owen M,Williams J,Goate A

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TLL2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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