C1QBP cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	C1QBP
Entrez Gene ID	708
Full Name	complement C1q binding protein
Synonyms	COXPD33,GC1QBP,HABP1,SF2p32,gC1Q-R,gC1qR,p32
General protein information	Preferred Names complement C1q binding protein Names complement component 1 Q subcomponent-binding protein, mitochondrial ASF/SF2-associated protein p32 C1q globular domain-binding protein complement component 1, q subcomponent binding protein glycoprotein gC1qBP hyaluronan-binding protein 1 mitochondrial matrix protein p32 p33 splicing factor SF2-associated protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17p13.2
Summary	The human complement subcomponent C1q associates with C1r and C1s in order to yield the first component of the serum complement system. The protein encoded by this gene is known to bind to the globular heads of C1q molecules and inhibit C1 activation. This protein has also been identified as the p32 subunit of pre-mRNA splicing factor SF2, as well as a hyaluronic acid-binding protein. [provided by RefSeq, Jul 2008].
Disorder MIM:	601269
Disorder Html:	Combined oxidative phosphorylation deficiency 33, 617713 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001212.3	NP_001203.1	complement component 1 Q subcomponent-binding protein, mitochondrial precursor
NM_001212.4	NP_001203.1	complement component 1 Q subcomponent-binding protein, mitochondrial precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	C1QBP	NP_001203.1
Canis lupus familiaris (dog)	C1QBP	XP_546568.2
Mus musculus (house mouse)	C1qbp	NP_031599.2
	LOC711817	XP_001100940.1
Bos taurus (cattle)	C1QBP	NP_001029699.1
Rattus norvegicus (Norway rat)	C1qbp	NP_062132.2
Drosophila melanogaster (fruit fly)	P32	NP_611243.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003987	XP_318437.3
Caenorhabditis elegans (roundworm)	cri-3	NP_497701.1
Gallus gallus (chicken)	C1QBP	XP_415748.4
Xenopus tropicalis (tropical clawed frog)	c1qbp	XP_002936868.2
Pan troglodytes (chimpanzee)	C1QBP	XP_003952998.1
Danio rerio (zebrafish)	c1qbp	NP_001017858.2

Gene Ontology
Bibliography

Related articles in PubMed

Globular C1 q receptor (p33) binds and stabilizes pro-inflammatory MCP-1: a novel mechanism for regulation of MCP-1 production and function.
Anders E, Nebel D, Westman J, Herwald H, Nilsson BO, Svensson D
The Biochemical journal(2018 Jan)

Biallelic C1QBP Mutations Cause Severe Neonatal-, Childhood-, or Later-Onset Cardiomyopathy Associated with Combined Respiratory-Chain Deficiencies.
Feichtinger RG, Ol?hov? M, Kishita Y, Garone C, Kremer LS, Yagi M, Uchiumi T, Jourdain AA, Thompson K, D'Souza AR, Kopajtich R, Alston CL, Koch J, Sperl W, Mastantuono E, Strom TM, Wortmann SB, Meitinger T, Pierre G, Chinnery PF, Chrzanowska-Lightowlers ZM, Lightowlers RN, DiMauro S, Calvo SE, Mootha VK, Moggio M, Sciacco M, Comi GP, Ronchi D, Murayama K, Ohtake A, Rebelo-Guiomar P, Kohda M, Kang D, Mayr JA, Taylor RW, Okazaki Y, Minczuk M, Prokisch H
American journal of human genetics101(4)525-538(2017 Oct)

Immunoregulation of Neutrophil Extracellular Trap Formation by Endothelial-Derived p33 (gC1q Receptor).
Neumann A, Papareddy P, Westman J, Hyldegaard O, Sn?ll J, Norrby-Teglund A, Herwald H
Journal of innate immunity(2017 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The RAP80 deficiency reduces the protein level of p32 and p32 dependent mitochondrial translating proteins such as Rieske and COX1.
Title: RAP80 binds p32 to preserve the functional integrity of mitochondria.

Mutation in C1QBP gene is associated with Severe Neonatal-, Childhood-, or Later-Onset Cardiomyopathy Associated with Combined Respiratory-Chain Deficiencies.
Title: Biallelic C1QBP Mutations Cause Severe Neonatal-, Childhood-, or Later-Onset Cardiomyopathy Associated with Combined Respiratory-Chain Deficiencies.

results implicate p32 as a key host factor for RSV virus production, and bring to light the potential importance of mitochondria in RSV infection
Title: Mitochondrial protein p32/HAPB1/gC1qR/C1qbp is required for efficient respiratory syncytial virus production.

these data suggest that C1QBP could regulate YBX1 to suppress the AR-enhanced RCC cell invasion. Targeting this newly identified C1QBP/YBX1/AR/MMP9 signal pathway may provide a new potential therapy to better suppress RCC metastasis.
Title: C1QBP Regulates YBX1 to Suppress the Androgen Receptor (AR)-Enhanced RCC Cell Invasion.

single nucleotide polymorphism srs2285747 of HABP1 increased breast cancer risk and elevated its protein expression in northern Chinese women
Title: Increased breast cancer risk with HABP1/p32/gC1qR genetic polymorphism rs2285747 and its upregulation in northern Chinese women.

The following C1QBP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the C1QBP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17284	NM_001212.4 Latest version!	Homo sapiens complement C1q binding protein (C1QBP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu17284	NM_001212.3	Homo sapiens complement C1q binding protein (C1QBP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

C1QBP ( NM_001212.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001203.1 Homo sapiens complement C1q binding protein (C1QBP), mRNA.

Price & Availability↑

CloneID	OHu17284
Clone ID Related Accession (Same CDS sequence)	NM_001212.3 , NM_001212.4
Accession Version	NM_001212.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 849bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-05
Organism	Homo sapiens(human)
Product	complement component 1 Q subcomponent-binding protein, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from L04636.1. On Mar 6, 2003 this sequence version replaced NM_001212.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L04636.1, SRR1163655.569913.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267753, SAMN03267760 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTGCCTC TGCTGCGCTG CGTGCCCCGT GTGCTGGGCT CCTCCGTCGC CGGCCTCCGC 
GCTGCCGCGC CCGCCTCGCC TTTCCGGCAG CTCCTGCAGC CGGCACCCCG GCTGTGCACC 
CGGCCCTTCG GGCTGCTCAG CGTGCGCGCA GGTTCCGAGC GGCGGCCGGG CCTCCTGCGG 
CCTCGCGGAC CCTGCGCCTG TGGCTGTGGC TGCGGCTCGC TGCACACCGA CGGAGACAAA 
GCTTTTGTTG ATTTCCTGAG TGATGAAATT AAGGAGGAAA GAAAAATTCA GAAGCATAAA 
ACCCTCCCTA AGATGTCTGG AGGTTGGGAG CTGGAACTGA ATGGGACAGA AGCGAAATTA 
GTGCGGAAAG TTGCCGGGGA AAAAATCACG GTCACTTTCA ACATTAACAA CAGCATCCCA 
CCAACATTTG ATGGTGAGGA GGAACCCTCG CAAGGGCAGA AGGTTGAAGA ACAGGAGCCT 
GAACTGACAT CAACTCCCAA TTTCGTGGTT GAAGTTATAA AGAATGATGA TGGCAAGAAG 
GCCCTTGTGT TGGACTGTCA TTATCCAGAG GATGAGGTTG GACAAGAAGA CGAGGCTGAG 
AGTGACATCT TCTCTATCAG GGAAGTTAGC TTTCAGTCCA CTGGCGAGTC TGAATGGAAG 
GATACTAATT ATACACTCAA CACAGATTCC TTGGACTGGG CCTTATATGA CCACCTAATG 
GATTTCCTTG CCGACCGAGG GGTGGACAAC ACTTTTGCAG ATGAGCTGGT GGAGCTCAGC 
ACAGCCCTGG AGCACCAGGA GTACATTACT TTTCTTGAAG ACCTCAAGAG TTTTGTCAAG 
AGCCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001203.1
CDS	79..927
Translation	MLPLLRCVPRVLGSSVAGLRAAAPASPFRQLLQPAPRLCTRPFGLLSVRAGSERRPGLLRPRGPCACGCGCGSLHTDGDKAFVDFLSDEIKEERKIQKHKTLPKMSGGWELELNGTEAKLVRKVAGEKITVTFNINNSIPPTFDGEEEPSQGQKVEEQEPELTSTPNFVVEVIKNDDGKKALVLDCHYPEDEVGQEDEAESDIFSIREVSFQSTGESEWKDTNYTLNTDSLDWALYDHLMDFLADRGVDNTFADELVELSTALEHQEYITFLEDLKSFVKSQ

Target ORF information:

RefSeq Version	NM_001212.3
Organism	Homo sapiens(human)
Definition	Homo sapiens complement C1q binding protein (C1QBP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001212.3

ORF Insert Sequence:

ATGCTGCCTC TGCTGCGCTG CGTGCCCCGT GTGCTGGGCT CCTCCGTCGC CGGCCTCCGC 
GCTGCCGCGC CCGCCTCGCC TTTCCGGCAG CTCCTGCAGC CGGCACCCCG GCTGTGCACC 
CGGCCCTTCG GGCTGCTCAG CGTGCGCGCA GGTTCCGAGC GGCGGCCGGG CCTCCTGCGG 
CCTCGCGGAC CCTGCGCCTG TGGCTGTGGC TGCGGCTCGC TGCACACCGA CGGAGACAAA 
GCTTTTGTTG ATTTCCTGAG TGATGAAATT AAGGAGGAAA GAAAAATTCA GAAGCATAAA 
ACCCTCCCTA AGATGTCTGG AGGTTGGGAG CTGGAACTGA ATGGGACAGA AGCGAAATTA 
GTGCGGAAAG TTGCCGGGGA AAAAATCACG GTCACTTTCA ACATTAACAA CAGCATCCCA 
CCAACATTTG ATGGTGAGGA GGAACCCTCG CAAGGGCAGA AGGTTGAAGA ACAGGAGCCT 
GAACTGACAT CAACTCCCAA TTTCGTGGTT GAAGTTATAA AGAATGATGA TGGCAAGAAG 
GCCCTTGTGT TGGACTGTCA TTATCCAGAG GATGAGGTTG GACAAGAAGA CGAGGCTGAG 
AGTGACATCT TCTCTATCAG GGAAGTTAGC TTTCAGTCCA CTGGCGAGTC TGAATGGAAG 
GATACTAATT ATACACTCAA CACAGATTCC TTGGACTGGG CCTTATATGA CCACCTAATG 
GATTTCCTTG CCGACCGAGG GGTGGACAAC ACTTTTGCAG ATGAGCTGGT GGAGCTCAGC 
ACAGCCCTGG AGCACCAGGA GTACATTACT TTTCTTGAAG ACCTCAAGAG TTTTGTCAAG 
AGCCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

C1QBP ( NM_001212.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001203.1 Homo sapiens complement C1q binding protein (C1QBP), mRNA.

Price & Availability↑

CloneID	OHu17284
Clone ID Related Accession (Same CDS sequence)	NM_001212.3 , NM_001212.4
Accession Version	NM_001212.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 849bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	complement component 1 Q subcomponent-binding protein, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC004148.1 and L04636.1. On Nov 23, 2018 this sequence version replaced NM_001212.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.675649.1, SRR1163655.239161.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267753, SAMN03267760 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000225698.8/ ENSP00000225698.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTGCCTC TGCTGCGCTG CGTGCCCCGT GTGCTGGGCT CCTCCGTCGC CGGCCTCCGC 
GCTGCCGCGC CCGCCTCGCC TTTCCGGCAG CTCCTGCAGC CGGCACCCCG GCTGTGCACC 
CGGCCCTTCG GGCTGCTCAG CGTGCGCGCA GGTTCCGAGC GGCGGCCGGG CCTCCTGCGG 
CCTCGCGGAC CCTGCGCCTG TGGCTGTGGC TGCGGCTCGC TGCACACCGA CGGAGACAAA 
GCTTTTGTTG ATTTCCTGAG TGATGAAATT AAGGAGGAAA GAAAAATTCA GAAGCATAAA 
ACCCTCCCTA AGATGTCTGG AGGTTGGGAG CTGGAACTGA ATGGGACAGA AGCGAAATTA 
GTGCGGAAAG TTGCCGGGGA AAAAATCACG GTCACTTTCA ACATTAACAA CAGCATCCCA 
CCAACATTTG ATGGTGAGGA GGAACCCTCG CAAGGGCAGA AGGTTGAAGA ACAGGAGCCT 
GAACTGACAT CAACTCCCAA TTTCGTGGTT GAAGTTATAA AGAATGATGA TGGCAAGAAG 
GCCCTTGTGT TGGACTGTCA TTATCCAGAG GATGAGGTTG GACAAGAAGA CGAGGCTGAG 
AGTGACATCT TCTCTATCAG GGAAGTTAGC TTTCAGTCCA CTGGCGAGTC TGAATGGAAG 
GATACTAATT ATACACTCAA CACAGATTCC TTGGACTGGG CCTTATATGA CCACCTAATG 
GATTTCCTTG CCGACCGAGG GGTGGACAAC ACTTTTGCAG ATGAGCTGGT GGAGCTCAGC 
ACAGCCCTGG AGCACCAGGA GTACATTACT TTTCTTGAAG ACCTCAAGAG TTTTGTCAAG 
AGCCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001203.1
CDS	83..931
Translation	MLPLLRCVPRVLGSSVAGLRAAAPASPFRQLLQPAPRLCTRPFGLLSVRAGSERRPGLLRPRGPCACGCGCGSLHTDGDKAFVDFLSDEIKEERKIQKHKTLPKMSGGWELELNGTEAKLVRKVAGEKITVTFNINNSIPPTFDGEEEPSQGQKVEEQEPELTSTPNFVVEVIKNDDGKKALVLDCHYPEDEVGQEDEAESDIFSIREVSFQSTGESEWKDTNYTLNTDSLDWALYDHLMDFLADRGVDNTFADELVELSTALEHQEYITFLEDLKSFVKSQ

Target ORF information:

RefSeq Version	NM_001212.4
Organism	Homo sapiens(human)
Definition	Homo sapiens complement C1q binding protein (C1QBP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001212.4

ORF Insert Sequence:

ATGCTGCCTC TGCTGCGCTG CGTGCCCCGT GTGCTGGGCT CCTCCGTCGC CGGCCTCCGC 
GCTGCCGCGC CCGCCTCGCC TTTCCGGCAG CTCCTGCAGC CGGCACCCCG GCTGTGCACC 
CGGCCCTTCG GGCTGCTCAG CGTGCGCGCA GGTTCCGAGC GGCGGCCGGG CCTCCTGCGG 
CCTCGCGGAC CCTGCGCCTG TGGCTGTGGC TGCGGCTCGC TGCACACCGA CGGAGACAAA 
GCTTTTGTTG ATTTCCTGAG TGATGAAATT AAGGAGGAAA GAAAAATTCA GAAGCATAAA 
ACCCTCCCTA AGATGTCTGG AGGTTGGGAG CTGGAACTGA ATGGGACAGA AGCGAAATTA 
GTGCGGAAAG TTGCCGGGGA AAAAATCACG GTCACTTTCA ACATTAACAA CAGCATCCCA 
CCAACATTTG ATGGTGAGGA GGAACCCTCG CAAGGGCAGA AGGTTGAAGA ACAGGAGCCT 
GAACTGACAT CAACTCCCAA TTTCGTGGTT GAAGTTATAA AGAATGATGA TGGCAAGAAG 
GCCCTTGTGT TGGACTGTCA TTATCCAGAG GATGAGGTTG GACAAGAAGA CGAGGCTGAG 
AGTGACATCT TCTCTATCAG GGAAGTTAGC TTTCAGTCCA CTGGCGAGTC TGAATGGAAG 
GATACTAATT ATACACTCAA CACAGATTCC TTGGACTGGG CCTTATATGA CCACCTAATG 
GATTTCCTTG CCGACCGAGG GGTGGACAAC ACTTTTGCAG ATGAGCTGGT GGAGCTCAGC 
ACAGCCCTGG AGCACCAGGA GTACATTACT TTTCTTGAAG ACCTCAAGAG TTTTGTCAAG 
AGCCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Globular C1 q receptor (p33) binds and stabilizes pro-inflammatory MCP-1: a novel mechanism for regulation of MCP-1 production and function.
The Biochemical journal(2018 Jan)
Anders E,Nebel D,Westman J,Herwald H,Nilsson BO,Svensson D

Biallelic C1QBP Mutations Cause Severe Neonatal-, Childhood-, or Later-Onset Cardiomyopathy Associated with Combined Respiratory-Chain Deficiencies.
American journal of human genetics101(4)525-538(2017 Oct)
Feichtinger RG,Ol?hov? M,Kishita Y,Garone C,Kremer LS,Yagi M,Uchiumi T,Jourdain AA,Thompson K,D'Souza AR,Kopajtich R,Alston CL,Koch J,Sperl W,Mastantuono E,Strom TM,Wortmann SB,Meitinger T,Pierre G,Chinnery PF,Chrzanowska-Lightowlers ZM,Lightowlers RN,DiMauro S,Calvo SE,Mootha VK,Moggio M,Sciacco M,Comi GP,Ronchi D,Murayama K,Ohtake A,Rebelo-Guiomar P,Kohda M,Kang D,Mayr JA,Taylor RW,Okazaki Y,Minczuk M,Prokisch H

Immunoregulation of Neutrophil Extracellular Trap Formation by Endothelial-Derived p33 (gC1q Receptor).
Journal of innate immunity(2017 Oct)
Neumann A,Papareddy P,Westman J,Hyldegaard O,Sn?ll J,Norrby-Teglund A,Herwald H

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C1QBP cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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