THOP1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	THOP1
Entrez Gene ID	7064
Full Name	thimet oligopeptidase 1
Synonyms	EP24.15,MEPD_HUMAN,MP78,TOP
General protein information	Preferred Names thimet oligopeptidase 1 Names thimet oligopeptidase endopeptidase 24.15
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.3
Summary	The protein encoded by this gene is a kininase that uses zinc as a cofactor. The encoded oligopeptidase cleaves cytosolic peptides, making them unavailable for display on antigen-presenting cells. This protein also cleaves neuropeptides under 20 aa in length and can degrade beta-amyloid precursor protein to amyloidogenic peptides. [provided by RefSeq, Nov 2015].
Disorder MIM:	601117

mRNA and Protein(s)

mRNA	Protein	Name
NM_003249.3	NP_003240.1	thimet oligopeptidase
XM_011528228.2	XP_011526530.1	thimet oligopeptidase isoform X1
NM_003249.4	NP_003240.1	thimet oligopeptidase
NM_003249.5	NP_003240.1	thimet oligopeptidase

Pathways from BioSystems

Homologies

Bos taurus (cattle)	THOP1	NP_001029163.2
Eremothecium gossypii	AGOS_AGR405C	NP_987071.2
Mus musculus (house mouse)	Thop1	NP_073144.3
Gallus gallus (chicken)	LOC426398	XP_004948943.1
Xenopus tropicalis (tropical clawed frog)	thop1	NP_001072409.1
Homo sapiens (human)	THOP1	NP_003240.1
Canis lupus familiaris (dog)	THOP1	XP_533954.3
Eremothecium gossypii	AGOS_AGR406C	NP_987072.1
Oryza sativa (rice)	Os01g0902200	NP_001045116.1
Rattus norvegicus (Norway rat)	Thop1	NP_742072.2
Danio rerio (zebrafish)	zgc:92139	NP_001002355.1
Arabidopsis thaliana (thale cress)	AT1G67690	NP_564902.4
Pan troglodytes (chimpanzee)	THOP1	XP_003953368.1
	THOP1	XP_001117760.2

Gene Ontology
Bibliography

Related articles in PubMed

Discovery of new candidate genes for rheumatoid arthritis through integration of genetic association data with expression pathway analysis.
Shchetynsky K, Diaz-Gallo LM, Folkersen L, Hensvold AH, Catrina AI, Berg L, Klareskog L, Padyukov L
Arthritis research & therapy19(1)19(2017 Feb)

Expression analysis of THOP1 in background liver, a prognostic predictive factor in hepatocellular carcinoma, extracted by multiarray analysis.
Nomoto S, Hishida M, Inokawa Y, Takano N, Kanda M, Nishikawa Y, Fujii T, Koike M, Sugimoto H, Kodera Y
Annals of surgical oncology21 Suppl 3S443-50(2014 Jun)

Expression of THOP1 and its relationship to prognosis in non-small cell lung cancer.
Qi L, Li SH, Si LB, Lu M, Tian H
PloS one9(9)e106665(2014)

Shear stress is a positive regulator of thimet oligopeptidase (EC3.4.24.15) in vascular endothelial cells: consequences for MHC1 levels.
Guinan AF, Rochfort KD, Fitzpatrick PA, Walsh TG, Pierotti AR, Phelan S, Murphy RP, Cummins PM
Cardiovascular research99(3)545-54(2013 Aug)

Recycling of the high valence States of heme proteins by cysteine residues of THIMET-oligopeptidase.
Ferreira JC, Icimoto MY, Marcondes MF, Oliveira V, Nascimento OR, Nantes IL
PloS one8(11)e79102(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that three new candidate genes involved in the development of rheumatoid arthritis (RA): ERBB2, TP53 and THOP1.
Title: Discovery of new candidate genes for rheumatoid arthritis through integration of genetic association data with expression pathway analysis.

Low THOP1 expression levels are associated with recurrence of hepatocellular carcinoma.
Title: Expression analysis of THOP1 in background liver, a prognostic predictive factor in hepatocellular carcinoma, extracted by multiarray analysis.

THOP1 may have clinical potentials to be employed as a promising biomarker to identify individuals with better prognosis and a novel antitumor agent for therapy of patients with NSCLC
Title: Expression of THOP1 and its relationship to prognosis in non-small cell lung cancer.

shear-dependent TOP induction down-regulates MHC1 levels, pointing to a role for TOP in the flow-mediated regulation of endothelial immunogenicity
Title: Shear stress is a positive regulator of thimet oligopeptidase (EC3.4.24.15) in vascular endothelial cells: consequences for MHC1 levels.

TCEP. Data indicate that THIMET-oligopeptidase (TOP) oxidation by H2O2 and high valence states of hemeproteins does not lead to enzyme oligomerization.
Title: Recycling of the high valence States of heme proteins by cysteine residues of THIMET-oligopeptidase.

The following THOP1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the THOP1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09031	NM_003249.5 Latest version!	Homo sapiens thimet oligopeptidase 1 (THOP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
OHu60993	XM_011528228.2 Latest version!	Homo sapiens thimet oligopeptidase 1 (THOP1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
View Old Accession Versions >>
OHu09031	NM_003249.3	Homo sapiens thimet oligopeptidase 1 (THOP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
OHu09031	NM_003249.4	Homo sapiens thimet oligopeptidase 1 (THOP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

THOP1 ( NM_003249.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003240.1 Homo sapiens thimet oligopeptidase 1 (THOP1), mRNA.

Price & Availability↑

CloneID	OHu09031
Clone ID Related Accession (Same CDS sequence)	NM_003249.3 , NM_003249.4 , NM_003249.5
Accession Version	NM_003249.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2070bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	thimet oligopeptidase
Comment

ATGAAGCCCC CCGCAGCCTG TGCAGGAGAC ATGGCGGACG CAGCATCTCC GTGCTCTGTG 
GTAAACGACC TGCGGTGGGA CCTGAGTGCC CAGCAGATAG AGGAGCGCAC CAGGGAGCTC 
ATCGAGCAGA CCAAGCGCGT GTATGACCAG GTTGGCACCC AGGAGTTTGA GGACGTGTCC 
TACGAGAGCA CGCTCAAGGC GCTGGCCGAT GTGGAGGTCA CCTACACAGT TCAGAGGAAT 
ATCCTTGACT TCCCCCAGCA TGTTTCCCCC TCCAAGGACA TCCGGACAGC CAGCACAGAG 
GCCGACAAGA AGCTCTCTGA GTTCGACGTG GAGATGAGCA TGAGGGAGGA CGTGTACCAG 
AGGATCGTGT GGCTCCAGGA GAAAGTTCAG AAGGACTCAC TGAGGCCCGA GGCTGCGCGG 
TACCTGGAGC GGCTAATCAA GCTGGGCCGG AGAAATGGGC TTCACCTCCC CAGAGAGACT 
CAGGAAAACA TCAAACGCAT CAAGAAGAAG CTGAGCCTTC TGTGCATCGA CTTCAACAAG 
AACCTGAACG AGGACACGAC CTTCCTGCCC TTCACGCTCC AGGAGCTAGG AGGGCTCCCC 
GAGGACTTTC TGAACTCCCT GGAGAAGATG GAGGACGGCA AGTTGAAGGT CACCCTCAAG 
TACCCCCATT ACTTCCCCCT CCTGAAGAAA TGCCACGTGC CTGAGACCAG GAGGAAAGTG 
GAGGAGGCCT TCAACTGCCG GTGCAAGGAG GAGAACTGCG CTATCCTCAA GGAGCTGGTG 
ACGCTGCGGG CCCAGAAGTC CCGCCTGCTG GGGTTCCACA CGCACGCCGA CTATGTCCTG 
GAGATGAACA TGGCCAAGAC CAGCCAGACC GTGGCCACCT TCCTAGATGA GCTGGCGCAG 
AAGCTGAAGC CCCTGGGGGA GCAGGAGCGT GCGGTGATTC TGGAGCTGAA GCGTGCGGAG 
TGCGAGCGCC GGGGCCTGCC CTTCGACGGC CGCATCCGTG CCTGGGACAT GCGCTACTAC 
ATGAACCAGG TGGAGGAGAC GCGCTACTGC GTGGACCAGA ACCTGCTCAA GGAGTACTTC 
CCCGTGCAGG TGGTCACGCA CGGGCTGCTG GGCATCTACC AGGAGCTCCT GGGGCTGGCC 
TTCCACCACG AGGAGGGCGC CAGTGCCTGG CATGAGGACG TGCGGCTCTA CACCGCGAGG 
GACGCGGCCT CGGGGGAGGT GGTCGGCAAG TTCTACCTGG ACCTGTACCC GCGGGAAGGA 
AAGTACGGGC ACGCGGCCTG CTTTGGCCTG CAGCCCGGCT GCCTGCGGCA GGATGGGAGC 
CGCCAGATCG CCATCGCGGC CATGGTGGCC AACTTCACCA AGCCCACAGC CGACGCGCCC 
TCGCTGCTGC AGCATGACGA GGTGGAGACC TACTTCCATG AGTTTGGCCA CGTGATGCAC 
CAGCTCTGCT CCCAGGCGGA GTTCGCCATG TTCAGCGGGA CCCACGTGGA GCGGGACTTT 
GTGGAGGCGC CGTCGCAGAT GCTGGAGAAC TGGGTGTGGG AGCAGGAGCC GCTGCTGCGG 
ATGTCGCGGC ACTACCGCAC AGGCAGCGCC GTGCCCCGGG AGCTCCTGGA GAAGCTCATT 
GAGTCCCGGC AGGCCAACAC AGGCCTCTTC AACCTGCGCC AGATCGTCCT CGCCAAGGTG 
GACCAGGCCC TGCACACGCA GACGGACGCA GACCCCGCCG AGGAGTATGC GCGGCTCTGC 
CAGGAGATCC TCGGGGTCCC GGCCACGCCA GGAACCAACA TGCCTGCAAC CTTCGGCCAT 
CTGGCAGGTG GCTACGACGC CCAGTACTAC GGGTACCTGT GGAGCGAGGT GTATTCCATG 
GACATGTTCC ACACGCGCTT CAAGCAGGAG GGTGTCCTGA ACAGCAAGGT TGGCATGGAT 
TACAGAAGCT GCATCCTGAG ACCCGGCGGT TCCGAGGATG CCAGCGCCAT GCTGAGGCGC 
TTCCTGGGCC GTGACCCCAA GCAGGACGCC TTCCTCCTGA GCAAGGGGCT GCAGGTCGGG 
GGCTGCGAGC CCGAGCCGCA GGTCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

NP_003240.1

Translation

MKPPAACAGDMADAASPCSVVNDLRWDLSAQQIEERTRELIEQTKRVYDQVGTQEFEDVSYESTLKALADVEVTYTVQRNILDFPQHVSPSKDIRTASTEADKKLSEFDVEMSMREDVYQRIVWLQEKVQKDSLRPEAARYLERLIKLGRRNGLHLPRETQENIKRIKKKLSLLCIDFNKNLNEDTTFLPFTLQELGGLPEDFLNSLEKMEDGKLKVTLKYPHYFPLLKKCHVPETRRKVEEAFNCRCKEENCAILKELVTLRAQKSRLLGFHTHADYVLEMNMAKTSQTVATFLDELAQKLKPLGEQERAVILELKRAECERRGLPFDGRIRAWDMRYYMNQVEETRYCVDQNLLKEYFPVQVVTHGLLGIYQELLGLAFHHEEGASAWHEDVRLYTARDAASGEVVGKFYLDLYPREGKYGHAACFGLQPGCLRQDGSRQIAIAAMVANFTKPTADAPSLLQHDEVETYFHEFGHVMHQLCSQAEFAMFSGTHVERDFVEAPSQMLENWVWEQEPLLRMSRHYRTGSAVPRELLEKLIESRQANTGLFNLRQIVLAKVDQALHTQTDADPAEEYARLCQEILGVPATPGTNMPATFGHLAGGYDAQYYGYLWSEVYSMDMFHTRFKQEGVLNSKVGMDYRSCILRPGGSEDASAMLRRFLGRDPKQDAFLLSKGLQVGGCEPEPQVC

Target ORF information:

RefSeq Version	NM_003249.3
Organism	Homo sapiens(Human)
Definition	Homo sapiens thimet oligopeptidase 1 (THOP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003249.3

ORF Insert Sequence:

ATGAAGCCCC CCGCAGCCTG TGCAGGAGAC ATGGCGGACG CAGCATCTCC GTGCTCTGTG 
GTAAACGACC TGCGGTGGGA CCTGAGTGCC CAGCAGATAG AGGAGCGCAC CAGGGAGCTC 
ATCGAGCAGA CCAAGCGCGT GTATGACCAG GTTGGCACCC AGGAGTTTGA GGACGTGTCC 
TACGAGAGCA CGCTCAAGGC GCTGGCCGAT GTGGAGGTCA CCTACACAGT TCAGAGGAAT 
ATCCTTGACT TCCCCCAGCA TGTTTCCCCC TCCAAGGACA TCCGGACAGC CAGCACAGAG 
GCCGACAAGA AGCTCTCTGA GTTCGACGTG GAGATGAGCA TGAGGGAGGA CGTGTACCAG 
AGGATCGTGT GGCTCCAGGA GAAAGTTCAG AAGGACTCAC TGAGGCCCGA GGCTGCGCGG 
TACCTGGAGC GGCTAATCAA GCTGGGCCGG AGAAATGGGC TTCACCTCCC CAGAGAGACT 
CAGGAAAACA TCAAACGCAT CAAGAAGAAG CTGAGCCTTC TGTGCATCGA CTTCAACAAG 
AACCTGAACG AGGACACGAC CTTCCTGCCC TTCACGCTCC AGGAGCTAGG AGGGCTCCCC 
GAGGACTTTC TGAACTCCCT GGAGAAGATG GAGGACGGCA AGTTGAAGGT CACCCTCAAG 
TACCCCCATT ACTTCCCCCT CCTGAAGAAA TGCCACGTGC CTGAGACCAG GAGGAAAGTG 
GAGGAGGCCT TCAACTGCCG GTGCAAGGAG GAGAACTGCG CTATCCTCAA GGAGCTGGTG 
ACGCTGCGGG CCCAGAAGTC CCGCCTGCTG GGGTTCCACA CGCACGCCGA CTATGTCCTG 
GAGATGAACA TGGCCAAGAC CAGCCAGACC GTGGCCACCT TCCTAGATGA GCTGGCGCAG 
AAGCTGAAGC CCCTGGGGGA GCAGGAGCGT GCGGTGATTC TGGAGCTGAA GCGTGCGGAG 
TGCGAGCGCC GGGGCCTGCC CTTCGACGGC CGCATCCGTG CCTGGGACAT GCGCTACTAC 
ATGAACCAGG TGGAGGAGAC GCGCTACTGC GTGGACCAGA ACCTGCTCAA GGAGTACTTC 
CCCGTGCAGG TGGTCACGCA CGGGCTGCTG GGCATCTACC AGGAGCTCCT GGGGCTGGCC 
TTCCACCACG AGGAGGGCGC CAGTGCCTGG CATGAGGACG TGCGGCTCTA CACCGCGAGG 
GACGCGGCCT CGGGGGAGGT GGTCGGCAAG TTCTACCTGG ACCTGTACCC GCGGGAAGGA 
AAGTACGGGC ACGCGGCCTG CTTTGGCCTG CAGCCCGGCT GCCTGCGGCA GGATGGGAGC 
CGCCAGATCG CCATCGCGGC CATGGTGGCC AACTTCACCA AGCCCACAGC CGACGCGCCC 
TCGCTGCTGC AGCATGACGA GGTGGAGACC TACTTCCATG AGTTTGGCCA CGTGATGCAC 
CAGCTCTGCT CCCAGGCGGA GTTCGCCATG TTCAGCGGGA CCCACGTGGA GCGGGACTTT 
GTGGAGGCGC CGTCGCAGAT GCTGGAGAAC TGGGTGTGGG AGCAGGAGCC GCTGCTGCGG 
ATGTCGCGGC ACTACCGCAC AGGCAGCGCC GTGCCCCGGG AGCTCCTGGA GAAGCTCATT 
GAGTCCCGGC AGGCCAACAC AGGCCTCTTC AACCTGCGCC AGATCGTCCT CGCCAAGGTG 
GACCAGGCCC TGCACACGCA GACGGACGCA GACCCCGCCG AGGAGTATGC GCGGCTCTGC 
CAGGAGATCC TCGGGGTCCC GGCCACGCCA GGAACCAACA TGCCTGCAAC CTTCGGCCAT 
CTGGCAGGTG GCTACGACGC CCAGTACTAC GGGTACCTGT GGAGCGAGGT GTATTCCATG 
GACATGTTCC ACACGCGCTT CAAGCAGGAG GGTGTCCTGA ACAGCAAGGT TGGCATGGAT 
TACAGAAGCT GCATCCTGAG ACCCGGCGGT TCCGAGGATG CCAGCGCCAT GCTGAGGCGC 
TTCCTGGGCC GTGACCCCAA GCAGGACGCC TTCCTCCTGA GCAAGGGGCT GCAGGTCGGG 
GGCTGCGAGC CCGAGCCGCA GGTCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

THOP1 ( NM_003249.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003240.1 Homo sapiens thimet oligopeptidase 1 (THOP1), mRNA.

Price & Availability↑

CloneID	OHu09031
Clone ID Related Accession (Same CDS sequence)	NM_003249.3 , NM_003249.4 , NM_003249.5
Accession Version	NM_003249.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2070bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-12
Organism	Homo sapiens(human)
Product	thimet oligopeptidase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BU849088.1, BC002391.2 and BU741442.1. On Nov 10, 2015 this sequence version replaced NM_003249.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC002391.2, SRR1803612.111602.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGCCCC CCGCAGCCTG TGCAGGAGAC ATGGCGGACG CAGCATCTCC GTGCTCTGTG 
GTAAACGACC TGCGGTGGGA CCTGAGTGCC CAGCAGATAG AGGAGCGCAC CAGGGAGCTC 
ATCGAGCAGA CCAAGCGCGT GTATGACCAG GTTGGCACCC AGGAGTTTGA GGACGTGTCC 
TACGAGAGCA CGCTCAAGGC GCTGGCCGAT GTGGAGGTCA CCTACACAGT TCAGAGGAAT 
ATCCTTGACT TCCCCCAGCA TGTTTCCCCC TCCAAGGACA TCCGGACAGC CAGCACAGAG 
GCCGACAAGA AGCTCTCTGA GTTCGACGTG GAGATGAGCA TGAGGGAGGA CGTGTACCAG 
AGGATCGTGT GGCTCCAGGA GAAAGTTCAG AAGGACTCAC TGAGGCCCGA GGCTGCGCGG 
TACCTGGAGC GGCTAATCAA GCTGGGCCGG AGAAATGGGC TTCACCTCCC CAGAGAGACT 
CAGGAAAACA TCAAACGCAT CAAGAAGAAG CTGAGCCTTC TGTGCATCGA CTTCAACAAG 
AACCTGAACG AGGACACGAC CTTCCTGCCC TTCACGCTCC AGGAGCTAGG AGGGCTCCCC 
GAGGACTTTC TGAACTCCCT GGAGAAGATG GAGGACGGCA AGTTGAAGGT CACCCTCAAG 
TACCCCCATT ACTTCCCCCT CCTGAAGAAA TGCCACGTGC CTGAGACCAG GAGGAAAGTG 
GAGGAGGCCT TCAACTGCCG GTGCAAGGAG GAGAACTGCG CTATCCTCAA GGAGCTGGTG 
ACGCTGCGGG CCCAGAAGTC CCGCCTGCTG GGGTTCCACA CGCACGCCGA CTATGTCCTG 
GAGATGAACA TGGCCAAGAC CAGCCAGACC GTGGCCACCT TCCTAGATGA GCTGGCGCAG 
AAGCTGAAGC CCCTGGGGGA GCAGGAGCGT GCGGTGATTC TGGAGCTGAA GCGTGCGGAG 
TGCGAGCGCC GGGGCCTGCC CTTCGACGGC CGCATCCGTG CCTGGGACAT GCGCTACTAC 
ATGAACCAGG TGGAGGAGAC GCGCTACTGC GTGGACCAGA ACCTGCTCAA GGAGTACTTC 
CCCGTGCAGG TGGTCACGCA CGGGCTGCTG GGCATCTACC AGGAGCTCCT GGGGCTGGCC 
TTCCACCACG AGGAGGGCGC CAGTGCCTGG CATGAGGACG TGCGGCTCTA CACCGCGAGG 
GACGCGGCCT CGGGGGAGGT GGTCGGCAAG TTCTACCTGG ACCTGTACCC GCGGGAAGGA 
AAGTACGGGC ACGCGGCCTG CTTTGGCCTG CAGCCCGGCT GCCTGCGGCA GGATGGGAGC 
CGCCAGATCG CCATCGCGGC CATGGTGGCC AACTTCACCA AGCCCACAGC CGACGCGCCC 
TCGCTGCTGC AGCATGACGA GGTGGAGACC TACTTCCATG AGTTTGGCCA CGTGATGCAC 
CAGCTCTGCT CCCAGGCGGA GTTCGCCATG TTCAGCGGGA CCCACGTGGA GCGGGACTTT 
GTGGAGGCGC CGTCGCAGAT GCTGGAGAAC TGGGTGTGGG AGCAGGAGCC GCTGCTGCGG 
ATGTCGCGGC ACTACCGCAC AGGCAGCGCC GTGCCCCGGG AGCTCCTGGA GAAGCTCATT 
GAGTCCCGGC AGGCCAACAC AGGCCTCTTC AACCTGCGCC AGATCGTCCT CGCCAAGGTG 
GACCAGGCCC TGCACACGCA GACGGACGCA GACCCCGCCG AGGAGTATGC GCGGCTCTGC 
CAGGAGATCC TCGGGGTCCC GGCCACGCCA GGAACCAACA TGCCTGCAAC CTTCGGCCAT 
CTGGCAGGTG GCTACGACGC CCAGTACTAC GGGTACCTGT GGAGCGAGGT GTATTCCATG 
GACATGTTCC ACACGCGCTT CAAGCAGGAG GGTGTCCTGA ACAGCAAGGT TGGCATGGAT 
TACAGAAGCT GCATCCTGAG ACCCGGCGGT TCCGAGGATG CCAGCGCCAT GCTGAGGCGC 
TTCCTGGGCC GTGACCCCAA GCAGGACGCC TTCCTCCTGA GCAAGGGGCT GCAGGTCGGG 
GGCTGCGAGC CCGAGCCGCA GGTCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003240.1
CDS	204..2273
Translation	MKPPAACAGDMADAASPCSVVNDLRWDLSAQQIEERTRELIEQTKRVYDQVGTQEFEDVSYESTLKALADVEVTYTVQRNILDFPQHVSPSKDIRTASTEADKKLSEFDVEMSMREDVYQRIVWLQEKVQKDSLRPEAARYLERLIKLGRRNGLHLPRETQENIKRIKKKLSLLCIDFNKNLNEDTTFLPFTLQELGGLPEDFLNSLEKMEDGKLKVTLKYPHYFPLLKKCHVPETRRKVEEAFNCRCKEENCAILKELVTLRAQKSRLLGFHTHADYVLEMNMAKTSQTVATFLDELAQKLKPLGEQERAVILELKRAECERRGLPFDGRIRAWDMRYYMNQVEETRYCVDQNLLKEYFPVQVVTHGLLGIYQELLGLAFHHEEGASAWHEDVRLYTARDAASGEVVGKFYLDLYPREGKYGHAACFGLQPGCLRQDGSRQIAIAAMVANFTKPTADAPSLLQHDEVETYFHEFGHVMHQLCSQAEFAMFSGTHVERDFVEAPSQMLENWVWEQEPLLRMSRHYRTGSAVPRELLEKLIESRQANTGLFNLRQIVLAKVDQALHTQTDADPAEEYARLCQEILGVPATPGTNMPATFGHLAGGYDAQYYGYLWSEVYSMDMFHTRFKQEGVLNSKVGMDYRSCILRPGGSEDASAMLRRFLGRDPKQDAFLLSKGLQVGGCEPEPQVC

Target ORF information:

RefSeq Version	NM_003249.4
Organism	Homo sapiens(human)
Definition	Homo sapiens thimet oligopeptidase 1 (THOP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003249.4

ORF Insert Sequence:

ATGAAGCCCC CCGCAGCCTG TGCAGGAGAC ATGGCGGACG CAGCATCTCC GTGCTCTGTG 
GTAAACGACC TGCGGTGGGA CCTGAGTGCC CAGCAGATAG AGGAGCGCAC CAGGGAGCTC 
ATCGAGCAGA CCAAGCGCGT GTATGACCAG GTTGGCACCC AGGAGTTTGA GGACGTGTCC 
TACGAGAGCA CGCTCAAGGC GCTGGCCGAT GTGGAGGTCA CCTACACAGT TCAGAGGAAT 
ATCCTTGACT TCCCCCAGCA TGTTTCCCCC TCCAAGGACA TCCGGACAGC CAGCACAGAG 
GCCGACAAGA AGCTCTCTGA GTTCGACGTG GAGATGAGCA TGAGGGAGGA CGTGTACCAG 
AGGATCGTGT GGCTCCAGGA GAAAGTTCAG AAGGACTCAC TGAGGCCCGA GGCTGCGCGG 
TACCTGGAGC GGCTAATCAA GCTGGGCCGG AGAAATGGGC TTCACCTCCC CAGAGAGACT 
CAGGAAAACA TCAAACGCAT CAAGAAGAAG CTGAGCCTTC TGTGCATCGA CTTCAACAAG 
AACCTGAACG AGGACACGAC CTTCCTGCCC TTCACGCTCC AGGAGCTAGG AGGGCTCCCC 
GAGGACTTTC TGAACTCCCT GGAGAAGATG GAGGACGGCA AGTTGAAGGT CACCCTCAAG 
TACCCCCATT ACTTCCCCCT CCTGAAGAAA TGCCACGTGC CTGAGACCAG GAGGAAAGTG 
GAGGAGGCCT TCAACTGCCG GTGCAAGGAG GAGAACTGCG CTATCCTCAA GGAGCTGGTG 
ACGCTGCGGG CCCAGAAGTC CCGCCTGCTG GGGTTCCACA CGCACGCCGA CTATGTCCTG 
GAGATGAACA TGGCCAAGAC CAGCCAGACC GTGGCCACCT TCCTAGATGA GCTGGCGCAG 
AAGCTGAAGC CCCTGGGGGA GCAGGAGCGT GCGGTGATTC TGGAGCTGAA GCGTGCGGAG 
TGCGAGCGCC GGGGCCTGCC CTTCGACGGC CGCATCCGTG CCTGGGACAT GCGCTACTAC 
ATGAACCAGG TGGAGGAGAC GCGCTACTGC GTGGACCAGA ACCTGCTCAA GGAGTACTTC 
CCCGTGCAGG TGGTCACGCA CGGGCTGCTG GGCATCTACC AGGAGCTCCT GGGGCTGGCC 
TTCCACCACG AGGAGGGCGC CAGTGCCTGG CATGAGGACG TGCGGCTCTA CACCGCGAGG 
GACGCGGCCT CGGGGGAGGT GGTCGGCAAG TTCTACCTGG ACCTGTACCC GCGGGAAGGA 
AAGTACGGGC ACGCGGCCTG CTTTGGCCTG CAGCCCGGCT GCCTGCGGCA GGATGGGAGC 
CGCCAGATCG CCATCGCGGC CATGGTGGCC AACTTCACCA AGCCCACAGC CGACGCGCCC 
TCGCTGCTGC AGCATGACGA GGTGGAGACC TACTTCCATG AGTTTGGCCA CGTGATGCAC 
CAGCTCTGCT CCCAGGCGGA GTTCGCCATG TTCAGCGGGA CCCACGTGGA GCGGGACTTT 
GTGGAGGCGC CGTCGCAGAT GCTGGAGAAC TGGGTGTGGG AGCAGGAGCC GCTGCTGCGG 
ATGTCGCGGC ACTACCGCAC AGGCAGCGCC GTGCCCCGGG AGCTCCTGGA GAAGCTCATT 
GAGTCCCGGC AGGCCAACAC AGGCCTCTTC AACCTGCGCC AGATCGTCCT CGCCAAGGTG 
GACCAGGCCC TGCACACGCA GACGGACGCA GACCCCGCCG AGGAGTATGC GCGGCTCTGC 
CAGGAGATCC TCGGGGTCCC GGCCACGCCA GGAACCAACA TGCCTGCAAC CTTCGGCCAT 
CTGGCAGGTG GCTACGACGC CCAGTACTAC GGGTACCTGT GGAGCGAGGT GTATTCCATG 
GACATGTTCC ACACGCGCTT CAAGCAGGAG GGTGTCCTGA ACAGCAAGGT TGGCATGGAT 
TACAGAAGCT GCATCCTGAG ACCCGGCGGT TCCGAGGATG CCAGCGCCAT GCTGAGGCGC 
TTCCTGGGCC GTGACCCCAA GCAGGACGCC TTCCTCCTGA GCAAGGGGCT GCAGGTCGGG 
GGCTGCGAGC CCGAGCCGCA GGTCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

THOP1 ( NM_003249.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_003240.1 Homo sapiens thimet oligopeptidase 1 (THOP1), mRNA.

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CloneID	OHu09031
Clone ID Related Accession (Same CDS sequence)	NM_003249.3 , NM_003249.4 , NM_003249.5
Accession Version	NM_003249.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2070bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-05
Organism	Homo sapiens(human)
Product	thimet oligopeptidase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BU849088.1, BC002391.2, BU741442.1 and AC006538.1. On Nov 22, 2018 this sequence version replaced NM_003249.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.110060.1, BC002391.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000307741.11/ ENSP00000304467.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAGCCCC CCGCAGCCTG TGCAGGAGAC ATGGCGGACG CAGCATCTCC GTGCTCTGTG 
GTAAACGACC TGCGGTGGGA CCTGAGTGCC CAGCAGATAG AGGAGCGCAC CAGGGAGCTC 
ATCGAGCAGA CCAAGCGCGT GTATGACCAG GTTGGCACCC AGGAGTTTGA GGACGTGTCC 
TACGAGAGCA CGCTCAAGGC GCTGGCCGAT GTGGAGGTCA CCTACACAGT TCAGAGGAAT 
ATCCTTGACT TCCCCCAGCA TGTTTCCCCC TCCAAGGACA TCCGGACAGC CAGCACAGAG 
GCCGACAAGA AGCTCTCTGA GTTCGACGTG GAGATGAGCA TGAGGGAGGA CGTGTACCAG 
AGGATCGTGT GGCTCCAGGA GAAAGTTCAG AAGGACTCAC TGAGGCCCGA GGCTGCGCGG 
TACCTGGAGC GGCTAATCAA GCTGGGCCGG AGAAATGGGC TTCACCTCCC CAGAGAGACT 
CAGGAAAACA TCAAACGCAT CAAGAAGAAG CTGAGCCTTC TGTGCATCGA CTTCAACAAG 
AACCTGAACG AGGACACGAC CTTCCTGCCC TTCACGCTCC AGGAGCTAGG AGGGCTCCCC 
GAGGACTTTC TGAACTCCCT GGAGAAGATG GAGGACGGCA AGTTGAAGGT CACCCTCAAG 
TACCCCCATT ACTTCCCCCT CCTGAAGAAA TGCCACGTGC CTGAGACCAG GAGGAAAGTG 
GAGGAGGCCT TCAACTGCCG GTGCAAGGAG GAGAACTGCG CTATCCTCAA GGAGCTGGTG 
ACGCTGCGGG CCCAGAAGTC CCGCCTGCTG GGGTTCCACA CGCACGCCGA CTATGTCCTG 
GAGATGAACA TGGCCAAGAC CAGCCAGACC GTGGCCACCT TCCTAGATGA GCTGGCGCAG 
AAGCTGAAGC CCCTGGGGGA GCAGGAGCGT GCGGTGATTC TGGAGCTGAA GCGTGCGGAG 
TGCGAGCGCC GGGGCCTGCC CTTCGACGGC CGCATCCGTG CCTGGGACAT GCGCTACTAC 
ATGAACCAGG TGGAGGAGAC GCGCTACTGC GTGGACCAGA ACCTGCTCAA GGAGTACTTC 
CCCGTGCAGG TGGTCACGCA CGGGCTGCTG GGCATCTACC AGGAGCTCCT GGGGCTGGCC 
TTCCACCACG AGGAGGGCGC CAGTGCCTGG CATGAGGACG TGCGGCTCTA CACCGCGAGG 
GACGCGGCCT CGGGGGAGGT GGTCGGCAAG TTCTACCTGG ACCTGTACCC GCGGGAAGGA 
AAGTACGGGC ACGCGGCCTG CTTTGGCCTG CAGCCCGGCT GCCTGCGGCA GGATGGGAGC 
CGCCAGATCG CCATCGCGGC CATGGTGGCC AACTTCACCA AGCCCACAGC CGACGCGCCC 
TCGCTGCTGC AGCATGACGA GGTGGAGACC TACTTCCATG AGTTTGGCCA CGTGATGCAC 
CAGCTCTGCT CCCAGGCGGA GTTCGCCATG TTCAGCGGGA CCCACGTGGA GCGGGACTTT 
GTGGAGGCGC CGTCGCAGAT GCTGGAGAAC TGGGTGTGGG AGCAGGAGCC GCTGCTGCGG 
ATGTCGCGGC ACTACCGCAC AGGCAGCGCC GTGCCCCGGG AGCTCCTGGA GAAGCTCATT 
GAGTCCCGGC AGGCCAACAC AGGCCTCTTC AACCTGCGCC AGATCGTCCT CGCCAAGGTG 
GACCAGGCCC TGCACACGCA GACGGACGCA GACCCCGCCG AGGAGTATGC GCGGCTCTGC 
CAGGAGATCC TCGGGGTCCC GGCCACGCCA GGAACCAACA TGCCTGCAAC CTTCGGCCAT 
CTGGCAGGTG GCTACGACGC CCAGTACTAC GGGTACCTGT GGAGCGAGGT GTATTCCATG 
GACATGTTCC ACACGCGCTT CAAGCAGGAG GGTGTCCTGA ACAGCAAGGT TGGCATGGAT 
TACAGAAGCT GCATCCTGAG ACCCGGCGGT TCCGAGGATG CCAGCGCCAT GCTGAGGCGC 
TTCCTGGGCC GTGACCCCAA GCAGGACGCC TTCCTCCTGA GCAAGGGGCT GCAGGTCGGG 
GGCTGCGAGC CCGAGCCGCA GGTCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003240.1
CDS	161..2230
Translation	MKPPAACAGDMADAASPCSVVNDLRWDLSAQQIEERTRELIEQTKRVYDQVGTQEFEDVSYESTLKALADVEVTYTVQRNILDFPQHVSPSKDIRTASTEADKKLSEFDVEMSMREDVYQRIVWLQEKVQKDSLRPEAARYLERLIKLGRRNGLHLPRETQENIKRIKKKLSLLCIDFNKNLNEDTTFLPFTLQELGGLPEDFLNSLEKMEDGKLKVTLKYPHYFPLLKKCHVPETRRKVEEAFNCRCKEENCAILKELVTLRAQKSRLLGFHTHADYVLEMNMAKTSQTVATFLDELAQKLKPLGEQERAVILELKRAECERRGLPFDGRIRAWDMRYYMNQVEETRYCVDQNLLKEYFPVQVVTHGLLGIYQELLGLAFHHEEGASAWHEDVRLYTARDAASGEVVGKFYLDLYPREGKYGHAACFGLQPGCLRQDGSRQIAIAAMVANFTKPTADAPSLLQHDEVETYFHEFGHVMHQLCSQAEFAMFSGTHVERDFVEAPSQMLENWVWEQEPLLRMSRHYRTGSAVPRELLEKLIESRQANTGLFNLRQIVLAKVDQALHTQTDADPAEEYARLCQEILGVPATPGTNMPATFGHLAGGYDAQYYGYLWSEVYSMDMFHTRFKQEGVLNSKVGMDYRSCILRPGGSEDASAMLRRFLGRDPKQDAFLLSKGLQVGGCEPEPQVC

Target ORF information:

RefSeq Version	NM_003249.5
Organism	Homo sapiens(human)
Definition	Homo sapiens thimet oligopeptidase 1 (THOP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003249.5

ORF Insert Sequence:

ATGAAGCCCC CCGCAGCCTG TGCAGGAGAC ATGGCGGACG CAGCATCTCC GTGCTCTGTG 
GTAAACGACC TGCGGTGGGA CCTGAGTGCC CAGCAGATAG AGGAGCGCAC CAGGGAGCTC 
ATCGAGCAGA CCAAGCGCGT GTATGACCAG GTTGGCACCC AGGAGTTTGA GGACGTGTCC 
TACGAGAGCA CGCTCAAGGC GCTGGCCGAT GTGGAGGTCA CCTACACAGT TCAGAGGAAT 
ATCCTTGACT TCCCCCAGCA TGTTTCCCCC TCCAAGGACA TCCGGACAGC CAGCACAGAG 
GCCGACAAGA AGCTCTCTGA GTTCGACGTG GAGATGAGCA TGAGGGAGGA CGTGTACCAG 
AGGATCGTGT GGCTCCAGGA GAAAGTTCAG AAGGACTCAC TGAGGCCCGA GGCTGCGCGG 
TACCTGGAGC GGCTAATCAA GCTGGGCCGG AGAAATGGGC TTCACCTCCC CAGAGAGACT 
CAGGAAAACA TCAAACGCAT CAAGAAGAAG CTGAGCCTTC TGTGCATCGA CTTCAACAAG 
AACCTGAACG AGGACACGAC CTTCCTGCCC TTCACGCTCC AGGAGCTAGG AGGGCTCCCC 
GAGGACTTTC TGAACTCCCT GGAGAAGATG GAGGACGGCA AGTTGAAGGT CACCCTCAAG 
TACCCCCATT ACTTCCCCCT CCTGAAGAAA TGCCACGTGC CTGAGACCAG GAGGAAAGTG 
GAGGAGGCCT TCAACTGCCG GTGCAAGGAG GAGAACTGCG CTATCCTCAA GGAGCTGGTG 
ACGCTGCGGG CCCAGAAGTC CCGCCTGCTG GGGTTCCACA CGCACGCCGA CTATGTCCTG 
GAGATGAACA TGGCCAAGAC CAGCCAGACC GTGGCCACCT TCCTAGATGA GCTGGCGCAG 
AAGCTGAAGC CCCTGGGGGA GCAGGAGCGT GCGGTGATTC TGGAGCTGAA GCGTGCGGAG 
TGCGAGCGCC GGGGCCTGCC CTTCGACGGC CGCATCCGTG CCTGGGACAT GCGCTACTAC 
ATGAACCAGG TGGAGGAGAC GCGCTACTGC GTGGACCAGA ACCTGCTCAA GGAGTACTTC 
CCCGTGCAGG TGGTCACGCA CGGGCTGCTG GGCATCTACC AGGAGCTCCT GGGGCTGGCC 
TTCCACCACG AGGAGGGCGC CAGTGCCTGG CATGAGGACG TGCGGCTCTA CACCGCGAGG 
GACGCGGCCT CGGGGGAGGT GGTCGGCAAG TTCTACCTGG ACCTGTACCC GCGGGAAGGA 
AAGTACGGGC ACGCGGCCTG CTTTGGCCTG CAGCCCGGCT GCCTGCGGCA GGATGGGAGC 
CGCCAGATCG CCATCGCGGC CATGGTGGCC AACTTCACCA AGCCCACAGC CGACGCGCCC 
TCGCTGCTGC AGCATGACGA GGTGGAGACC TACTTCCATG AGTTTGGCCA CGTGATGCAC 
CAGCTCTGCT CCCAGGCGGA GTTCGCCATG TTCAGCGGGA CCCACGTGGA GCGGGACTTT 
GTGGAGGCGC CGTCGCAGAT GCTGGAGAAC TGGGTGTGGG AGCAGGAGCC GCTGCTGCGG 
ATGTCGCGGC ACTACCGCAC AGGCAGCGCC GTGCCCCGGG AGCTCCTGGA GAAGCTCATT 
GAGTCCCGGC AGGCCAACAC AGGCCTCTTC AACCTGCGCC AGATCGTCCT CGCCAAGGTG 
GACCAGGCCC TGCACACGCA GACGGACGCA GACCCCGCCG AGGAGTATGC GCGGCTCTGC 
CAGGAGATCC TCGGGGTCCC GGCCACGCCA GGAACCAACA TGCCTGCAAC CTTCGGCCAT 
CTGGCAGGTG GCTACGACGC CCAGTACTAC GGGTACCTGT GGAGCGAGGT GTATTCCATG 
GACATGTTCC ACACGCGCTT CAAGCAGGAG GGTGTCCTGA ACAGCAAGGT TGGCATGGAT 
TACAGAAGCT GCATCCTGAG ACCCGGCGGT TCCGAGGATG CCAGCGCCAT GCTGAGGCGC 
TTCCTGGGCC GTGACCCCAA GCAGGACGCC TTCCTCCTGA GCAAGGGGCT GCAGGTCGGG 
GGCTGCGAGC CCGAGCCGCA GGTCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

THOP1 ( XM_011528228.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011526530.1 Homo sapiens thimet oligopeptidase 1 (THOP1), transcript variant X1, mRNA.

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CloneID	OHu60993
Clone ID Related Accession (Same CDS sequence)	XM_011528228.2
Accession Version	XM_011528228.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1443bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	thimet oligopeptidase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011528228.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGGACG GCAAGTTGAA GGTCACCCTC AAGTACCCCC ATTACTTCCC CCTCCTGAAG 
AAATGCCACG TGCCTGAGAC CAGGAGGAAA GTGGAGGAGG CCTTCAACTG CCGGTGCAAG 
GAGGAGAACT GCGCTATCCT CAAGGAGCTG GTGACGCTGC GGGCCCAGAA GTCCCGCCTG 
CTGGGGTTCC ACACGCACGC CGACTATGTC CTGGAGATGA ACATGGCCAA GACCAGCCAG 
ACCGTGGCCA CCTTCCTAGA TGAGCTGGCG CAGAAGCTGA AGCCCCTGGG GGAGCAGGAG 
CGTGCGGTGA TTCTGGAGCT GAAGCGTGCG GAGTGCGAGC GCCGGGGCCT GCCCTTCGAC 
GGCCGCATCC GTGCCTGGGA CATGCGCTAC TACATGAACC AGGTGGAGGA GACGCGCTAC 
TGCGTGGACC AGAACCTGCT CAAGGAGTAC TTCCCCGTGC AGGTGGTCAC GCACGGGCTG 
CTGGGCATCT ACCAGGAGCT CCTGGGGCTG GCCTTCCACC ACGAGGAGGG CGCCAGTGCC 
TGGCATGAGG ACGTGCGGCT CTACACCGCG AGGGACGCGG CCTCGGGGGA GGTGGTCGGC 
AAGTTCTACC TGGACCTGTA CCCGCGGGAA GGAAAGTACG GGCACGCGGC CTGCTTTGGC 
CTGCAGCCCG GCTGCCTGCG GCAGGATGGG AGCCGCCAGA TCGCCATCGC GGCCATGGTG 
GCCAACTTCA CCAAGCCCAC AGCCGACGCG CCCTCGCTGC TGCAGCATGA CGAGGTGGAG 
ACCTACTTCC ATGAGTTTGG CCACGTGATG CACCAGCTCT GCTCCCAGGC GGAGTTCGCC 
ATGTTCAGCG GGACCCACGT GGAGCGGGAC TTTGTGGAGG CGCCGTCGCA GATGCTGGAG 
AACTGGGTGT GGGAGCAGGA GCCGCTGCTG CGGATGTCGC GGCACTACCG CACAGGCAGC 
GCCGTGCCCC GGGAGCTCCT GGAGAAGCTC ATTGAGTCCC GGCAGGCCAA CACAGGCCTC 
TTCAACCTGC GCCAGATCGT CCTCGCCAAG GTGGACCAGG CCCTGCACAC GCAGACGGAC 
GCAGACCCCG CCGAGGAGTA TGCGCGGCTC TGCCAGGAGA TCCTCGGGGT CCCGGCCACG 
CCAGGAACCA ACATGCCTGC AACCTTCGGC CATCTGGCAG GTGGCTACGA CGCCCAGTAC 
TACGGGTACC TGTGGAGCGA GGTGTATTCC ATGGACATGT TCCACACGCG CTTCAAGCAG 
GAGGGTGTCC TGAACAGCAA GGTTGGCATG GATTACAGAA GCTGCATCCT GAGACCCGGC 
GGTTCCGAGG ATGCCAGCGC CATGCTGAGG CGCTTCCTGG GCCGTGACCC CAAGCAGGAC 
GCCTTCCTCC TGAGCAAGGG GCTGCAGGTC GGGGGCTGCG AGCCCGAGCC GCAGGTCTGC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011526530.1
CDS	1778..3220
Translation	MEDGKLKVTLKYPHYFPLLKKCHVPETRRKVEEAFNCRCKEENCAILKELVTLRAQKSRLLGFHTHADYVLEMNMAKTSQTVATFLDELAQKLKPLGEQERAVILELKRAECERRGLPFDGRIRAWDMRYYMNQVEETRYCVDQNLLKEYFPVQVVTHGLLGIYQELLGLAFHHEEGASAWHEDVRLYTARDAASGEVVGKFYLDLYPREGKYGHAACFGLQPGCLRQDGSRQIAIAAMVANFTKPTADAPSLLQHDEVETYFHEFGHVMHQLCSQAEFAMFSGTHVERDFVEAPSQMLENWVWEQEPLLRMSRHYRTGSAVPRELLEKLIESRQANTGLFNLRQIVLAKVDQALHTQTDADPAEEYARLCQEILGVPATPGTNMPATFGHLAGGYDAQYYGYLWSEVYSMDMFHTRFKQEGVLNSKVGMDYRSCILRPGGSEDASAMLRRFLGRDPKQDAFLLSKGLQVGGCEPEPQVC

Target ORF information:

RefSeq Version	XM_011528228.2
Organism	Homo sapiens(human)
Definition	Homo sapiens thimet oligopeptidase 1 (THOP1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011528228.2

ORF Insert Sequence:

ATGGAGGACG GCAAGTTGAA GGTCACCCTC AAGTACCCCC ATTACTTCCC CCTCCTGAAG 
AAATGCCACG TGCCTGAGAC CAGGAGGAAA GTGGAGGAGG CCTTCAACTG CCGGTGCAAG 
GAGGAGAACT GCGCTATCCT CAAGGAGCTG GTGACGCTGC GGGCCCAGAA GTCCCGCCTG 
CTGGGGTTCC ACACGCACGC CGACTATGTC CTGGAGATGA ACATGGCCAA GACCAGCCAG 
ACCGTGGCCA CCTTCCTAGA TGAGCTGGCG CAGAAGCTGA AGCCCCTGGG GGAGCAGGAG 
CGTGCGGTGA TTCTGGAGCT GAAGCGTGCG GAGTGCGAGC GCCGGGGCCT GCCCTTCGAC 
GGCCGCATCC GTGCCTGGGA CATGCGCTAC TACATGAACC AGGTGGAGGA GACGCGCTAC 
TGCGTGGACC AGAACCTGCT CAAGGAGTAC TTCCCCGTGC AGGTGGTCAC GCACGGGCTG 
CTGGGCATCT ACCAGGAGCT CCTGGGGCTG GCCTTCCACC ACGAGGAGGG CGCCAGTGCC 
TGGCATGAGG ACGTGCGGCT CTACACCGCG AGGGACGCGG CCTCGGGGGA GGTGGTCGGC 
AAGTTCTACC TGGACCTGTA CCCGCGGGAA GGAAAGTACG GGCACGCGGC CTGCTTTGGC 
CTGCAGCCCG GCTGCCTGCG GCAGGATGGG AGCCGCCAGA TCGCCATCGC GGCCATGGTG 
GCCAACTTCA CCAAGCCCAC AGCCGACGCG CCCTCGCTGC TGCAGCATGA CGAGGTGGAG 
ACCTACTTCC ATGAGTTTGG CCACGTGATG CACCAGCTCT GCTCCCAGGC GGAGTTCGCC 
ATGTTCAGCG GGACCCACGT GGAGCGGGAC TTTGTGGAGG CGCCGTCGCA GATGCTGGAG 
AACTGGGTGT GGGAGCAGGA GCCGCTGCTG CGGATGTCGC GGCACTACCG CACAGGCAGC 
GCCGTGCCCC GGGAGCTCCT GGAGAAGCTC ATTGAGTCCC GGCAGGCCAA CACAGGCCTC 
TTCAACCTGC GCCAGATCGT CCTCGCCAAG GTGGACCAGG CCCTGCACAC GCAGACGGAC 
GCAGACCCCG CCGAGGAGTA TGCGCGGCTC TGCCAGGAGA TCCTCGGGGT CCCGGCCACG 
CCAGGAACCA ACATGCCTGC AACCTTCGGC CATCTGGCAG GTGGCTACGA CGCCCAGTAC 
TACGGGTACC TGTGGAGCGA GGTGTATTCC ATGGACATGT TCCACACGCG CTTCAAGCAG 
GAGGGTGTCC TGAACAGCAA GGTTGGCATG GATTACAGAA GCTGCATCCT GAGACCCGGC 
GGTTCCGAGG ATGCCAGCGC CATGCTGAGG CGCTTCCTGG GCCGTGACCC CAAGCAGGAC 
GCCTTCCTCC TGAGCAAGGG GCTGCAGGTC GGGGGCTGCG AGCCCGAGCC GCAGGTCTGC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Discovery of new candidate genes for rheumatoid arthritis through integration of genetic association data with expression pathway analysis.
Arthritis research & therapy19(1)19(2017 Feb)
Shchetynsky K,Diaz-Gallo LM,Folkersen L,Hensvold AH,Catrina AI,Berg L,Klareskog L,Padyukov L

Expression analysis of THOP1 in background liver, a prognostic predictive factor in hepatocellular carcinoma, extracted by multiarray analysis.
Annals of surgical oncology21 Suppl 3S443-50(2014 Jun)
Nomoto S,Hishida M,Inokawa Y,Takano N,Kanda M,Nishikawa Y,Fujii T,Koike M,Sugimoto H,Kodera Y

Expression of THOP1 and its relationship to prognosis in non-small cell lung cancer.
PloS one9(9)e106665(2014)
Qi L,Li SH,Si LB,Lu M,Tian H

Shear stress is a positive regulator of thimet oligopeptidase (EC3.4.24.15) in vascular endothelial cells: consequences for MHC1 levels.
Cardiovascular research99(3)545-54(2013 Aug)
Guinan AF,Rochfort KD,Fitzpatrick PA,Walsh TG,Pierotti AR,Phelan S,Murphy RP,Cummins PM

Recycling of the high valence States of heme proteins by cysteine residues of THIMET-oligopeptidase.
PloS one8(11)e79102(2013)
Ferreira JC,Icimoto MY,Marcondes MF,Oliveira V,Nascimento OR,Nantes IL

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THOP1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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