TGM3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TGM3
Entrez Gene ID	7053
Full Name	transglutaminase 3
Synonyms	TGE,UHS2
General protein information	Preferred Names transglutaminase 3 Names protein-glutamine gamma-glutamyltransferase E E polypeptide, protein-glutamine-gamma-glutamyltransferase TG(E) TGase E TGase-3 transglutaminase E
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20p13
Summary	Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene consists of two polypeptide chains activated from a single precursor protein by proteolysis. The encoded protein is involved the later stages of cell envelope formation in the epidermis and hair follicle. [provided by RefSeq, Jul 2008].
Disorder MIM:	600238
Disorder Html:	?Uncombable hair syndrome 2, 617251 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_003245.3	NP_003236.3	protein-glutamine gamma-glutamyltransferase E
NM_003245.4	NP_003236.3	protein-glutamine gamma-glutamyltransferase E

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	TGM3	XP_005634933.1
Mus musculus (house mouse)	Tgm3	NP_033400.2
Gallus gallus (chicken)	TGM3	XP_417392.3
	TGM3	XP_001113845.1
Rattus norvegicus (Norway rat)	Tgm3	NP_001102429.1
Xenopus tropicalis (tropical clawed frog)	tgm6	NP_001120399.1
Homo sapiens (human)	TGM3	NP_003236.3
Pan troglodytes (chimpanzee)	TGM3	XP_514468.2
Bos taurus (cattle)	TGM3	NP_001095318.1

Gene Ontology
Bibliography

Related articles in PubMed

Ex vivo Culture of Duodenal Biopsies from Patients with Dermatitis Herpetiformis Indicates that Transglutaminase 3 Antibody Production Occurs in the Gut.
Hietikko M, Hervonen K, Ilus T, Salmi T, Huhtala H, Laurila K, Rauhavirta T, Reunala T, Kaukinen K, Lindfors K
Acta dermato-venereologica(2017 Nov)

Receptor-stimulated transamidation induces activation of Rac1 and Cdc42 and the regulation of dendritic spines.
Mi Z, Si T, Kapadia K, Li Q, Muma NA
Neuropharmacology11793-105(2017 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

studies demonstrate that TGase-catalyzed transamidation and activation of rac1 and cdc42 results from stimulation of multiple types of receptors and this novel signaling pathway can regulate dendritic spine morphology and plasticity.
Title: Receptor-stimulated transamidation induces activation of Rac1 and Cdc42 and the regulation of dendritic spines.

The two enzymes PADI3 and TGM3, responsible for posttranslational protein modifications, and their target structural protein TCHH are all involved in hair shaft formation.
Title: Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome.

Data indicate a decrease in transglutaminases TG1 and TG3 transcripts by about 70% in foreskins from patients with balanitis xerotica obliterans (BXO) BXO in comparison with patients without BXO and an increase in transglutaminase TG2 mRNA levels by 2.9 fold.
Title: Expression of Transglutaminase in Foreskin of Children with Balanitis Xerotica Obliterans.

Our data collectively demonstrate that TGM3 can be a candidate tumor suppressor that is able to induce esophageal cancer cell proliferation and migration
Title: Transglutaminase 3 protein modulates human esophageal cancer cell growth by targeting the NF-?B signaling pathway.

Transglutaminase 3 present in the IgA aggregates in dermatitis herpetiformis skin is enzymatically active and binds soluble fibrinogen.
Title: Transglutaminase 3 present in the IgA aggregates in dermatitis herpetiformis skin is enzymatically active and binds soluble fibrinogen.

The following TGM3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TGM3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31856	NM_003245.4 Latest version!	Homo sapiens transglutaminase 3 (TGM3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$265.30 $379.00
View Old Accession Versions >>
OHu31856	NM_003245.3	Homo sapiens transglutaminase 3 (TGM3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TGM3 ( NM_003245.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003236.3 Homo sapiens transglutaminase 3 (TGM3), mRNA.

Price & Availability↑

CloneID	OHu31856
Clone ID Related Accession (Same CDS sequence)	NM_003245.3 , NM_003245.4
Accession Version	NM_003245.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2082bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-09
Organism	Homo sapiens(human)
Product	protein-glutamine gamma-glutamyltransferase E
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC373633.1, BC109076.1, BC109075.1 and AI216028.1. This sequence is a reference standard in the RefSeqGene project. On Jun 6, 2008 this sequence version replaced NM_003245.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK290324.1, L10386.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMEA2147596 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGCTC TAGGAGTCCA GAGTATCAAC TGGCAGACGG CCTTCAACCG ACAAGCGCAT 
CACACAGACA AGTTCTCCAG CCAGGAGCTC ATCTTGCGGA GAGGCCAAAA CTTCCAGGTC 
TTAATGATCA TGAACAAAGG CCTTGGCTCT AACGAAAGAC TGGAGTTCAT TGTCTCCACA 
GGGCCTTACC CCTCAGAGTC GGCCATGACG AAGGCTGTGT TTCCACTCTC CAATGGCAGT 
AGTGGTGGCT GGAGTGCGGT GCTTCAGGCC AGCAATGGCA ATACTCTGAC TATCAGCATC 
TCCAGTCCTG CCAGCGCACC CATAGGACGG TACACAATGG CCCTCCAGAT CTTCTCCCAG 
GGCGGCATCT CCTCTGTGAA ACTTGGGACG TTCATACTGC TTTTTAACCC CTGGCTGAAT 
GTGGATAGCG TCTTTATGGG TAACCACGCT GAGAGAGAAG AGTATGTTCA GGAAGATGCC 
GGCATCATCT TTGTGGGAAG CACAAACCGA ATTGGCATGA TTGGCTGGAA CTTTGGACAG 
TTTGAAGAAG ACATTCTCAG CATCTGCCTC TCAATCTTGG ATAGGAGTCT GAATTTCCGC 
CGTGACGCTG CTACTGATGT GGCCAGCAGA AATGACCCCA AATACGTTGG CCGGGTGCTG 
AGTGCCATGA TCAATAGCAA TGATGACAAT GGTGTGCTTG CTGGGAATTG GAGCGGCACT 
TACACCGGTG GCCGGGACCC AAGGAGCTGG AACGGCAGCG TGGAGATCCT CAAAAATTGG 
AAAAAATCTG GCTTCAGCCC AGTCCGATAT GGCCAGTGCT GGGTCTTTGC TGGGACCCTC 
AACACAGCGC TGCGGTCTTT GGGGATTCCT TCCCGGGTGA TCACCAACTT CAACTCAGCT 
CATGACACAG ACCGAAATCT CAGTGTGGAT GTGTACTACG ACCCCATGGG AAACCCCCTG 
GACAAGGGTA GTGATAGCGT ATGGAATTTC CATGTCTGGA ATGAAGGCTG GTTTGTGAGG 
TCTGACCTGG GCCCCTCGTA CGGTGGATGG CAGGTGTTGG ATGCTACCCC GCAGGAAAGA 
AGCCAAGGGG TGTTCCAGTG CGGCCCCGCT TCGGTCATTG GTGTTCGAGA GGGTGATGTG 
CAGCTGAACT TCGACATGCC CTTTATCTTC GCGGAGGTTA ATGCCGACCG CATCACCTGG 
CTGTACGACA ACACCACTGG CAAACAGTGG AAGAATTCCG TGAACAGTCA CACCATTGGC 
AGGTACATCA GCACCAAGGC GGTGGGCAGC AATGCTCGCA TGGACGTCAC GGACAAGTAC 
AAGTACCCAG AAGGCTCTGA CCAGGAAAGA CAAGTGTTCC AAAAGGCTTT GGGGAAACTT 
AAACCCAACA CGCCATTTGC CGCGACGTCT TCAATGGGTT TGGAAACAGA GGAACAGGAG 
CCCAGCATCA TCGGGAAGCT GAAGGTCGCT GGCATGCTGG CAGTAGGCAA AGAAGTCAAC 
CTGGTCCTAC TGCTCAAAAA CCTGAGCAGG GATACGAAGA CAGTGACAGT GAACATGACA 
GCCTGGACCA TCATCTACAA CGGCACGCTT GTACATGAAG TGTGGAAGGA CTCTGCCACA 
ATGTCCCTGG ACCCTGAGGA AGAGGCAGAA CATCCCATAA AGATCTCGTA CGCTCAGTAT 
GAGAAGTACC TGAAGTCAGA CAACATGATC CGGATCACAG CGGTGTGCAA GGTCCCAGAT 
GAGTCTGAGG TGGTGGTGGA GCGGGACATC ATCCTGGACA ACCCCACCTT GACCCTGGAG 
GTGCTGAACG AGGCTCGTGT GCGGAAGCCT GTGAACGTGC AGATGCTCTT CTCCAATCCA 
CTGGATGAGC CGGTGAGGGA CTGCGTGCTG ATGGTGGAGG GAAGCGGCCT GCTGTTGGGT 
AACCTGAAGA TCGACGTGCC GACCCTAGGG CCCAAGGAGG GGTCCCGGGT CCGTTTTGAT 
ATCCTGCCCT CCCGGAGTGG CACCAAGCAA CTGCTCGCCG ACTTCTCCTG CAACAAGTTC 
CCTGCAATCA AGGCCATGTT GTCCATCGAT GTAGCCGAAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003236.3
CDS	98..2179
Translation	MAALGVQSINWQTAFNRQAHHTDKFSSQELILRRGQNFQVLMIMNKGLGSNERLEFIVSTGPYPSESAMTKAVFPLSNGSSGGWSAVLQASNGNTLTISISSPASAPIGRYTMALQIFSQGGISSVKLGTFILLFNPWLNVDSVFMGNHAEREEYVQEDAGIIFVGSTNRIGMIGWNFGQFEEDILSICLSILDRSLNFRRDAATDVASRNDPKYVGRVLSAMINSNDDNGVLAGNWSGTYTGGRDPRSWNGSVEILKNWKKSGFSPVRYGQCWVFAGTLNTALRSLGIPSRVITNFNSAHDTDRNLSVDVYYDPMGNPLDKGSDSVWNFHVWNEGWFVRSDLGPSYGGWQVLDATPQERSQGVFQCGPASVIGVREGDVQLNFDMPFIFAEVNADRITWLYDNTTGKQWKNSVNSHTIGRYISTKAVGSNARMDVTDKYKYPEGSDQERQVFQKALGKLKPNTPFAATSSMGLETEEQEPSIIGKLKVAGMLAVGKEVNLVLLLKNLSRDTKTVTVNMTAWTIIYNGTLVHEVWKDSATMSLDPEEEAEHPIKISYAQYEKYLKSDNMIRITAVCKVPDESEVVVERDIILDNPTLTLEVLNEARVRKPVNVQMLFSNPLDEPVRDCVLMVEGSGLLLGNLKIDVPTLGPKEGSRVRFDILPSRSGTKQLLADFSCNKFPAIKAMLSIDVAE

Target ORF information:

RefSeq Version	NM_003245.3
Organism	Homo sapiens(human)
Definition	Homo sapiens transglutaminase 3 (TGM3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003245.3

ORF Insert Sequence:

ATGGCTGCTC TAGGAGTCCA GAGTATCAAC TGGCAGACGG CCTTCAACCG ACAAGCGCAT 
CACACAGACA AGTTCTCCAG CCAGGAGCTC ATCTTGCGGA GAGGCCAAAA CTTCCAGGTC 
TTAATGATCA TGAACAAAGG CCTTGGCTCT AACGAAAGAC TGGAGTTCAT TGTCTCCACA 
GGGCCTTACC CCTCAGAGTC GGCCATGACG AAGGCTGTGT TTCCACTCTC CAATGGCAGT 
AGTGGTGGCT GGAGTGCGGT GCTTCAGGCC AGCAATGGCA ATACTCTGAC TATCAGCATC 
TCCAGTCCTG CCAGCGCACC CATAGGACGG TACACAATGG CCCTCCAGAT CTTCTCCCAG 
GGCGGCATCT CCTCTGTGAA ACTTGGGACG TTCATACTGC TTTTTAACCC CTGGCTGAAT 
GTGGATAGCG TCTTTATGGG TAACCACGCT GAGAGAGAAG AGTATGTTCA GGAAGATGCC 
GGCATCATCT TTGTGGGAAG CACAAACCGA ATTGGCATGA TTGGCTGGAA CTTTGGACAG 
TTTGAAGAAG ACATTCTCAG CATCTGCCTC TCAATCTTGG ATAGGAGTCT GAATTTCCGC 
CGTGACGCTG CTACTGATGT GGCCAGCAGA AATGACCCCA AATACGTTGG CCGGGTGCTG 
AGTGCCATGA TCAATAGCAA TGATGACAAT GGTGTGCTTG CTGGGAATTG GAGCGGCACT 
TACACCGGTG GCCGGGACCC AAGGAGCTGG AACGGCAGCG TGGAGATCCT CAAAAATTGG 
AAAAAATCTG GCTTCAGCCC AGTCCGATAT GGCCAGTGCT GGGTCTTTGC TGGGACCCTC 
AACACAGCGC TGCGGTCTTT GGGGATTCCT TCCCGGGTGA TCACCAACTT CAACTCAGCT 
CATGACACAG ACCGAAATCT CAGTGTGGAT GTGTACTACG ACCCCATGGG AAACCCCCTG 
GACAAGGGTA GTGATAGCGT ATGGAATTTC CATGTCTGGA ATGAAGGCTG GTTTGTGAGG 
TCTGACCTGG GCCCCTCGTA CGGTGGATGG CAGGTGTTGG ATGCTACCCC GCAGGAAAGA 
AGCCAAGGGG TGTTCCAGTG CGGCCCCGCT TCGGTCATTG GTGTTCGAGA GGGTGATGTG 
CAGCTGAACT TCGACATGCC CTTTATCTTC GCGGAGGTTA ATGCCGACCG CATCACCTGG 
CTGTACGACA ACACCACTGG CAAACAGTGG AAGAATTCCG TGAACAGTCA CACCATTGGC 
AGGTACATCA GCACCAAGGC GGTGGGCAGC AATGCTCGCA TGGACGTCAC GGACAAGTAC 
AAGTACCCAG AAGGCTCTGA CCAGGAAAGA CAAGTGTTCC AAAAGGCTTT GGGGAAACTT 
AAACCCAACA CGCCATTTGC CGCGACGTCT TCAATGGGTT TGGAAACAGA GGAACAGGAG 
CCCAGCATCA TCGGGAAGCT GAAGGTCGCT GGCATGCTGG CAGTAGGCAA AGAAGTCAAC 
CTGGTCCTAC TGCTCAAAAA CCTGAGCAGG GATACGAAGA CAGTGACAGT GAACATGACA 
GCCTGGACCA TCATCTACAA CGGCACGCTT GTACATGAAG TGTGGAAGGA CTCTGCCACA 
ATGTCCCTGG ACCCTGAGGA AGAGGCAGAA CATCCCATAA AGATCTCGTA CGCTCAGTAT 
GAGAAGTACC TGAAGTCAGA CAACATGATC CGGATCACAG CGGTGTGCAA GGTCCCAGAT 
GAGTCTGAGG TGGTGGTGGA GCGGGACATC ATCCTGGACA ACCCCACCTT GACCCTGGAG 
GTGCTGAACG AGGCTCGTGT GCGGAAGCCT GTGAACGTGC AGATGCTCTT CTCCAATCCA 
CTGGATGAGC CGGTGAGGGA CTGCGTGCTG ATGGTGGAGG GAAGCGGCCT GCTGTTGGGT 
AACCTGAAGA TCGACGTGCC GACCCTAGGG CCCAAGGAGG GGTCCCGGGT CCGTTTTGAT 
ATCCTGCCCT CCCGGAGTGG CACCAAGCAA CTGCTCGCCG ACTTCTCCTG CAACAAGTTC 
CCTGCAATCA AGGCCATGTT GTCCATCGAT GTAGCCGAAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TGM3 ( NM_003245.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003236.3 Homo sapiens transglutaminase 3 (TGM3), mRNA.

Price & Availability↑

CloneID	OHu31856
Clone ID Related Accession (Same CDS sequence)	NM_003245.3 , NM_003245.4
Accession Version	NM_003245.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2082bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	protein-glutamine gamma-glutamyltransferase E
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC373633.1, BC109076.1, BC109075.1 and AI216028.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_003245.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK290324.1, L10386.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMEA2147596 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000381458.6/ ENSP00000370867.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTGCTC TAGGAGTCCA GAGTATCAAC TGGCAGACGG CCTTCAACCG ACAAGCGCAT 
CACACAGACA AGTTCTCCAG CCAGGAGCTC ATCTTGCGGA GAGGCCAAAA CTTCCAGGTC 
TTAATGATCA TGAACAAAGG CCTTGGCTCT AACGAAAGAC TGGAGTTCAT TGTCTCCACA 
GGGCCTTACC CCTCAGAGTC GGCCATGACG AAGGCTGTGT TTCCACTCTC CAATGGCAGT 
AGTGGTGGCT GGAGTGCGGT GCTTCAGGCC AGCAATGGCA ATACTCTGAC TATCAGCATC 
TCCAGTCCTG CCAGCGCACC CATAGGACGG TACACAATGG CCCTCCAGAT CTTCTCCCAG 
GGCGGCATCT CCTCTGTGAA ACTTGGGACG TTCATACTGC TTTTTAACCC CTGGCTGAAT 
GTGGATAGCG TCTTTATGGG TAACCACGCT GAGAGAGAAG AGTATGTTCA GGAAGATGCC 
GGCATCATCT TTGTGGGAAG CACAAACCGA ATTGGCATGA TTGGCTGGAA CTTTGGACAG 
TTTGAAGAAG ACATTCTCAG CATCTGCCTC TCAATCTTGG ATAGGAGTCT GAATTTCCGC 
CGTGACGCTG CTACTGATGT GGCCAGCAGA AATGACCCCA AATACGTTGG CCGGGTGCTG 
AGTGCCATGA TCAATAGCAA TGATGACAAT GGTGTGCTTG CTGGGAATTG GAGCGGCACT 
TACACCGGTG GCCGGGACCC AAGGAGCTGG AACGGCAGCG TGGAGATCCT CAAAAATTGG 
AAAAAATCTG GCTTCAGCCC AGTCCGATAT GGCCAGTGCT GGGTCTTTGC TGGGACCCTC 
AACACAGCGC TGCGGTCTTT GGGGATTCCT TCCCGGGTGA TCACCAACTT CAACTCAGCT 
CATGACACAG ACCGAAATCT CAGTGTGGAT GTGTACTACG ACCCCATGGG AAACCCCCTG 
GACAAGGGTA GTGATAGCGT ATGGAATTTC CATGTCTGGA ATGAAGGCTG GTTTGTGAGG 
TCTGACCTGG GCCCCTCGTA CGGTGGATGG CAGGTGTTGG ATGCTACCCC GCAGGAAAGA 
AGCCAAGGGG TGTTCCAGTG CGGCCCCGCT TCGGTCATTG GTGTTCGAGA GGGTGATGTG 
CAGCTGAACT TCGACATGCC CTTTATCTTC GCGGAGGTTA ATGCCGACCG CATCACCTGG 
CTGTACGACA ACACCACTGG CAAACAGTGG AAGAATTCCG TGAACAGTCA CACCATTGGC 
AGGTACATCA GCACCAAGGC GGTGGGCAGC AATGCTCGCA TGGACGTCAC GGACAAGTAC 
AAGTACCCAG AAGGCTCTGA CCAGGAAAGA CAAGTGTTCC AAAAGGCTTT GGGGAAACTT 
AAACCCAACA CGCCATTTGC CGCGACGTCT TCAATGGGTT TGGAAACAGA GGAACAGGAG 
CCCAGCATCA TCGGGAAGCT GAAGGTCGCT GGCATGCTGG CAGTAGGCAA AGAAGTCAAC 
CTGGTCCTAC TGCTCAAAAA CCTGAGCAGG GATACGAAGA CAGTGACAGT GAACATGACA 
GCCTGGACCA TCATCTACAA CGGCACGCTT GTACATGAAG TGTGGAAGGA CTCTGCCACA 
ATGTCCCTGG ACCCTGAGGA AGAGGCAGAA CATCCCATAA AGATCTCGTA CGCTCAGTAT 
GAGAAGTACC TGAAGTCAGA CAACATGATC CGGATCACAG CGGTGTGCAA GGTCCCAGAT 
GAGTCTGAGG TGGTGGTGGA GCGGGACATC ATCCTGGACA ACCCCACCTT GACCCTGGAG 
GTGCTGAACG AGGCTCGTGT GCGGAAGCCT GTGAACGTGC AGATGCTCTT CTCCAATCCA 
CTGGATGAGC CGGTGAGGGA CTGCGTGCTG ATGGTGGAGG GAAGCGGCCT GCTGTTGGGT 
AACCTGAAGA TCGACGTGCC GACCCTAGGG CCCAAGGAGG GGTCCCGGGT CCGTTTTGAT 
ATCCTGCCCT CCCGGAGTGG CACCAAGCAA CTGCTCGCCG ACTTCTCCTG CAACAAGTTC 
CCTGCAATCA AGGCCATGTT GTCCATCGAT GTAGCCGAAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003236.3
CDS	64..2145
Translation	MAALGVQSINWQTAFNRQAHHTDKFSSQELILRRGQNFQVLMIMNKGLGSNERLEFIVSTGPYPSESAMTKAVFPLSNGSSGGWSAVLQASNGNTLTISISSPASAPIGRYTMALQIFSQGGISSVKLGTFILLFNPWLNVDSVFMGNHAEREEYVQEDAGIIFVGSTNRIGMIGWNFGQFEEDILSICLSILDRSLNFRRDAATDVASRNDPKYVGRVLSAMINSNDDNGVLAGNWSGTYTGGRDPRSWNGSVEILKNWKKSGFSPVRYGQCWVFAGTLNTALRSLGIPSRVITNFNSAHDTDRNLSVDVYYDPMGNPLDKGSDSVWNFHVWNEGWFVRSDLGPSYGGWQVLDATPQERSQGVFQCGPASVIGVREGDVQLNFDMPFIFAEVNADRITWLYDNTTGKQWKNSVNSHTIGRYISTKAVGSNARMDVTDKYKYPEGSDQERQVFQKALGKLKPNTPFAATSSMGLETEEQEPSIIGKLKVAGMLAVGKEVNLVLLLKNLSRDTKTVTVNMTAWTIIYNGTLVHEVWKDSATMSLDPEEEAEHPIKISYAQYEKYLKSDNMIRITAVCKVPDESEVVVERDIILDNPTLTLEVLNEARVRKPVNVQMLFSNPLDEPVRDCVLMVEGSGLLLGNLKIDVPTLGPKEGSRVRFDILPSRSGTKQLLADFSCNKFPAIKAMLSIDVAE

Target ORF information:

RefSeq Version	NM_003245.4
Organism	Homo sapiens(human)
Definition	Homo sapiens transglutaminase 3 (TGM3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003245.4

ORF Insert Sequence:

ATGGCTGCTC TAGGAGTCCA GAGTATCAAC TGGCAGACGG CCTTCAACCG ACAAGCGCAT 
CACACAGACA AGTTCTCCAG CCAGGAGCTC ATCTTGCGGA GAGGCCAAAA CTTCCAGGTC 
TTAATGATCA TGAACAAAGG CCTTGGCTCT AACGAAAGAC TGGAGTTCAT TGTCTCCACA 
GGGCCTTACC CCTCAGAGTC GGCCATGACG AAGGCTGTGT TTCCACTCTC CAATGGCAGT 
AGTGGTGGCT GGAGTGCGGT GCTTCAGGCC AGCAATGGCA ATACTCTGAC TATCAGCATC 
TCCAGTCCTG CCAGCGCACC CATAGGACGG TACACAATGG CCCTCCAGAT CTTCTCCCAG 
GGCGGCATCT CCTCTGTGAA ACTTGGGACG TTCATACTGC TTTTTAACCC CTGGCTGAAT 
GTGGATAGCG TCTTTATGGG TAACCACGCT GAGAGAGAAG AGTATGTTCA GGAAGATGCC 
GGCATCATCT TTGTGGGAAG CACAAACCGA ATTGGCATGA TTGGCTGGAA CTTTGGACAG 
TTTGAAGAAG ACATTCTCAG CATCTGCCTC TCAATCTTGG ATAGGAGTCT GAATTTCCGC 
CGTGACGCTG CTACTGATGT GGCCAGCAGA AATGACCCCA AATACGTTGG CCGGGTGCTG 
AGTGCCATGA TCAATAGCAA TGATGACAAT GGTGTGCTTG CTGGGAATTG GAGCGGCACT 
TACACCGGTG GCCGGGACCC AAGGAGCTGG AACGGCAGCG TGGAGATCCT CAAAAATTGG 
AAAAAATCTG GCTTCAGCCC AGTCCGATAT GGCCAGTGCT GGGTCTTTGC TGGGACCCTC 
AACACAGCGC TGCGGTCTTT GGGGATTCCT TCCCGGGTGA TCACCAACTT CAACTCAGCT 
CATGACACAG ACCGAAATCT CAGTGTGGAT GTGTACTACG ACCCCATGGG AAACCCCCTG 
GACAAGGGTA GTGATAGCGT ATGGAATTTC CATGTCTGGA ATGAAGGCTG GTTTGTGAGG 
TCTGACCTGG GCCCCTCGTA CGGTGGATGG CAGGTGTTGG ATGCTACCCC GCAGGAAAGA 
AGCCAAGGGG TGTTCCAGTG CGGCCCCGCT TCGGTCATTG GTGTTCGAGA GGGTGATGTG 
CAGCTGAACT TCGACATGCC CTTTATCTTC GCGGAGGTTA ATGCCGACCG CATCACCTGG 
CTGTACGACA ACACCACTGG CAAACAGTGG AAGAATTCCG TGAACAGTCA CACCATTGGC 
AGGTACATCA GCACCAAGGC GGTGGGCAGC AATGCTCGCA TGGACGTCAC GGACAAGTAC 
AAGTACCCAG AAGGCTCTGA CCAGGAAAGA CAAGTGTTCC AAAAGGCTTT GGGGAAACTT 
AAACCCAACA CGCCATTTGC CGCGACGTCT TCAATGGGTT TGGAAACAGA GGAACAGGAG 
CCCAGCATCA TCGGGAAGCT GAAGGTCGCT GGCATGCTGG CAGTAGGCAA AGAAGTCAAC 
CTGGTCCTAC TGCTCAAAAA CCTGAGCAGG GATACGAAGA CAGTGACAGT GAACATGACA 
GCCTGGACCA TCATCTACAA CGGCACGCTT GTACATGAAG TGTGGAAGGA CTCTGCCACA 
ATGTCCCTGG ACCCTGAGGA AGAGGCAGAA CATCCCATAA AGATCTCGTA CGCTCAGTAT 
GAGAAGTACC TGAAGTCAGA CAACATGATC CGGATCACAG CGGTGTGCAA GGTCCCAGAT 
GAGTCTGAGG TGGTGGTGGA GCGGGACATC ATCCTGGACA ACCCCACCTT GACCCTGGAG 
GTGCTGAACG AGGCTCGTGT GCGGAAGCCT GTGAACGTGC AGATGCTCTT CTCCAATCCA 
CTGGATGAGC CGGTGAGGGA CTGCGTGCTG ATGGTGGAGG GAAGCGGCCT GCTGTTGGGT 
AACCTGAAGA TCGACGTGCC GACCCTAGGG CCCAAGGAGG GGTCCCGGGT CCGTTTTGAT 
ATCCTGCCCT CCCGGAGTGG CACCAAGCAA CTGCTCGCCG ACTTCTCCTG CAACAAGTTC 
CCTGCAATCA AGGCCATGTT GTCCATCGAT GTAGCCGAAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ex vivo Culture of Duodenal Biopsies from Patients with Dermatitis Herpetiformis Indicates that Transglutaminase 3 Antibody Production Occurs in the Gut.
Acta dermato-venereologica(2017 Nov)
Hietikko M,Hervonen K,Ilus T,Salmi T,Huhtala H,Laurila K,Rauhavirta T,Reunala T,Kaukinen K,Lindfors K

Receptor-stimulated transamidation induces activation of Rac1 and Cdc42 and the regulation of dendritic spines.
Neuropharmacology11793-105(2017 May)
Mi Z,Si T,Kapadia K,Li Q,Muma NA

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TGM3 cDNA ORF clone, Homo sapiens(human)

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