BYSL cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	BYSL
Entrez Gene ID	705
Full Name	bystin like
Synonyms	BYSTIN,Enp1
General protein information	Preferred Names bystin like Names bystin by the ribosomal protein s6 gene, drosophila, homolog-like
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p21.1
Summary	Bystin is expressed as a 2-kb major transcript and a 3.6-kb minor transcript in SNG-M cells and in human trophoblastic teratocarcinoma HT-H cells. Protein binding assays determined that bystin binds directly to trophinin and tastin, and that binding is enhanced when cytokeratins 8 and 18 are present. Immunocytochemistry of HT-H cells showed that bystin colocalizes with trophinin, tastin, and the cytokeratins, suggesting that these molecules form a complex in trophectoderm cells at the time of implantation. Using immunohistochemistry it was determined that trophinin and bystin are found in the placenta from the sixth week of pregnancy. Both proteins were localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. After week 10, the levels of trophinin, tastin, and bystin decreased and then disappeared from placental villi. [provided by RefSeq, Jul 2008].
Disorder MIM:	603871

mRNA and Protein(s)

mRNA	Protein	Name
NM_004053.3	NP_004044.3	bystin
NM_004053.4	NP_004044.3	bystin

Pathways from BioSystems

Homologies

Homo sapiens (human)	BYSL	NP_004044.3
	BYSL	XP_001085599.1
Danio rerio (zebrafish)	bysl	NP_957400.1
Bos taurus (cattle)	BYSL	NP_001014924.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002923	XP_311981.5
Saccharomyces cerevisiae (baker's yeast)	ENP1	NP_009806.3
Kluyveromyces lactis	KLLA0F06622g	XP_455380.1
Schizosaccharomyces pombe (fission yeast)	SPBC13G1.09	NP_596559.1
Oryza sativa (rice)	Os09g0352400	NP_001062958.1
Xenopus tropicalis (tropical clawed frog)	bysl	NP_001015838.1
Rattus norvegicus (Norway rat)	Bysl	NP_872615.3
Drosophila melanogaster (fruit fly)	bys	NP_511074.1
Eremothecium gossypii	AGOS_AFL044W	NP_985504.2
Mus musculus (house mouse)	Bysl	NP_058555.3
Magnaporthe oryzae (rice blast fungus)	MGG_11193	XP_003714471.1
Arabidopsis thaliana (thale cress)	AT1G31660	NP_174447.2
Canis lupus familiaris (dog)	BYSL	XP_532135.4
Gallus gallus (chicken)	BYSL	XP_418047.3
Caenorhabditis elegans (roundworm)	byn-1	NP_498510.1
Neurospora crassa	NCU08323	XP_962536.2

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
Yachie N, Petsalaki E, Mellor JC, Weile J, Jacob Y, Verby M, Ozturk SB, Li S, Cote AG, Mosca R, Knapp JJ, Ko M, Yu A, Gebbia M, Sahni N, Yi S, Tyagi T, Sheykhkarimli D, Roth JF, Wong C, Musa L, Snider J, Liu YC, Yu H, Braun P, Stagljar I, Hao T, Calderwood MA, Pelletier L, Aloy P, Hill DE, Vidal M, Roth FP
Molecular systems biology12(4)863(2016 Apr)

Genome-wide RNAi Screening Identifies Protein Modules Required for 40S Subunit Synthesis in Human Cells.
Badertscher L, Wild T, Montellese C, Alexander LT, Bammert L, Sarazova M, Stebler M, Csucs G, Mayer TU, Zamboni N, Zemp I, Horvath P, Kutay U
Cell reports13(12)2879-91(2015 Dec)

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
Perry JR, Day F, Elks CE, Sulem P, Thompson DJ, Ferreira T, He C, Chasman DI, Esko T, Thorleifsson G, Albrecht E, Ang WQ, Corre T, Cousminer DL, Feenstra B, Franceschini N, Ganna A, Johnson AD, Kjellqvist S, Lunetta KL, McMahon G, Nolte IM, Paternoster L, Porcu E, Smith AV, Stolk L, Teumer A, T?ernikova N, Tikkanen E, Ulivi S, Wagner EK, Amin N, Bierut LJ, Byrne EM, Hottenga JJ, Koller DL, Mangino M, Pers TH, Yerges-Armstrong LM, Zhao JH, Andrulis IL, Anton-Culver H, Atsma F, Bandinelli S, Beckmann MW, Benitez J, Blomqvist C, Bojesen SE, Bolla MK, Bonanni B, Brauch H, Brenner H, Buring JE, Chang-Claude J, Chanock S, Chen J, Chenevix-Trench G, Coll?e JM, Couch FJ, Couper D, Coveillo AD, Cox A, Czene K, D'adamo AP, Smith GD, De Vivo I, Demerath EW, Dennis J, Devilee P, Dieffenbach AK, Dunning AM, Eiriksdottir G, Eriksson JG, Fasching PA, Ferrucci L, Flesch-Janys D, Flyger H, Foroud T, Franke L, Garcia ME, Garc?a-Closas M, Geller F, de Geus EE, Giles GG, Gudbjartsson DF, Gudnason V, Gu?nel P, Guo S, Hall P, Hamann U, Haring R, Hartman CA, Heath AC, Hofman A, Hooning MJ, Hopper JL, Hu FB, Hunter DJ, Karasik D, Kiel DP, Knight JA, Kosma VM, Kutalik Z, Lai S, Lambrechts D, Lindblom A, M?gi R, Magnusson PK, Mannermaa A, Martin NG, Masson G, McArdle PF, McArdle WL, Melbye M, Michailidou K, Mihailov E, Milani L, Milne RL, Nevanlinna H, Neven P, Nohr EA, Oldehinkel AJ, Oostra BA, Palotie A, Peacock M, Pedersen NL, Peterlongo P, Peto J, Pharoah PD, Postma DS, Pouta A, Pylk?s K, Radice P, Ring S, Rivadeneira F, Robino A, Rose LM, Rudolph A, Salomaa V, Sanna S, Schlessinger D, Schmidt MK, Southey MC, Sovio U, Stampfer MJ, St?ckl D, Storniolo AM, Timpson NJ, Tyrer J, Visser JA, Vollenweider P, V?lzke H, Waeber G, Waldenberger M, Wallaschofski H, Wang Q, Willemsen G, Winqvist R, Wolffenbuttel BH, Wright MJ, , , , , , , Boomsma DI, Econs MJ, Khaw KT, Loos RJ, McCarthy MI, Montgomery GW, Rice JP, Streeten EA, Thorsteinsdottir U, van Duijn CM, Alizadeh BZ, Bergmann S, Boerwinkle E, Boyd HA, Crisponi L, Gasparini P, Gieger C, Harris TB, Ingelsson E, J?rvelin MR, Kraft P, Lawlor D, Metspalu A, Pennell CE, Ridker PM, Snieder H, S?rensen TI, Spector TD, Strachan DP, Uitterlinden AG, Wareham NJ, Widen E, Zygmunt M, Murray A, Easton DF, Stefansson K, Murabito JM, Ong KK
Nature514(7520)92-97(2014 Oct)

GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children.
Li J, Glessner JT, Zhang H, Hou C, Wei Z, Bradfield JP, Mentch FD, Guo Y, Kim C, Xia Q, Chiavacci RM, Thomas KA, Qiu H, Grant SF, Furth SL, Hakonarson H, Sleiman PM
Human molecular genetics22(7)1457-64(2013 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.

bystin is necessary for efficient cleavage of the internal transcribed spacer 1 at site 2 and for further processing of the pre-rRNA.
Title: Analysis of two human pre-ribosomal factors, bystin and hTsr1, highlights differences in evolution of ribosome biogenesis between yeast and mammals.

review of the roles of bystin in embryo implantation, assembly of ribosomes, and as a target of c-MYC
Title: The role of bystin in embryo implantation and in ribosomal biogenesis.

These results suggest that, while bystin may play multiple roles in mammalian cells, a conserved function is to facilitate ribosome biogenesis required for cell growth.
Title: Bystin in human cancer cells: intracellular localization and function in ribosome biogenesis.

The following BYSL gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BYSL cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu16171	NM_004053.4 Latest version!	Homo sapiens bystin like (BYSL), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu16171	NM_004053.3	Homo sapiens bystin like (BYSL), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

BYSL ( NM_004053.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004044.3 Homo sapiens bystin like (BYSL), mRNA.

Price & Availability↑

CloneID	OHu16171
Clone ID Related Accession (Same CDS sequence)	NM_004053.3 , NM_004053.4
Accession Version	NM_004053.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1314bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	bystin
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC050645.1, BC062627.1 and BC007340.2. On Aug 12, 2004 this sequence version replaced NM_004053.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC050645.1, SRR1163658.352338.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCAAAT TCAAGGCGGC CCGTGGGGTG GGGGGTCAGG AAAAACATGC GCCCCTGGCC 
GATCAGATCC TGGCTGGGAA TGCGGTGCGG GCGGGGGTCC GGGAGAAGCG GCGGGGTCGC 
GGGACAGGAG AAGCGGAGGA AGAGTATGTG GGGCCCCGGC TGAGCCGACG GATTTTGCAG 
CAAGCACGGC AGCAACAGGA GGAACTCGAG GCCGAGCATG GGACTGGGGA CAAGCCCGCG 
GCGCCGCGGG AACGCACCAC GCGGCTGGGT CCAAGAATGC CTCAGGATGG ATCAGATGAC 
GAGGACGAGG AGTGGCCCAC CCTGGAGAAG GCTGCCACAA TGACAGCAGC GGGCCATCAT 
GCAGAGGTGG TTGTGGACCC TGAGGATGAG CGTGCCATAG AGATGTTCAT GAACAAGAAC 
CCTCCTGCCA GGCGCACCCT GGCTGACATC ATCATGGAGA AGCTGACTGA GAAGCAGACA 
GAGGTTGAGA CAGTCATGTC AGAGGTGTCG GGCTTCCCTA TGCCCCAGCT GGACCCCCGG 
GTCCTAGAAG TGTACAGGGG GGTCCGGGAG GTATTATCTA AGTACCGCAG TGGAAAACTG 
CCCAAGGCAT TTAAGATCAT CCCTGCACTC TCCAACTGGG AGCAAATCCT CTACGTCACA 
GAGCCGGAGG CCTGGACTGC AGCTGCCATG TACCAGGCCA CCAGGATTTT TGCCTCTAAC 
CTGAAGGAAC GCATGGCCCA GCGCTTCTAC AACCTTGTCC TGCTCCCTCG AGTACGAGAT 
GACGTTGCTG AATACAAACG ACTCAACTTC CATCTCTACA TGGCTCTCAA GAAGGCCCTT 
TTCAAACCTG GAGCCTGGTT CAAAGGGATC CTGATTCCAC TGTGCGAGTC TGGCACTTGT 
ACCCTCCGGG AAGCCATCAT TGTGGGTAGC ATCATCACCA AGTGCTCCAT CCCTGTGTTG 
CACTCCAGTG CGGCCATGCT GAAAATTGCT GAGATGGAAT ACAGCGGTGC CAACAGCATC 
TTCCTGCGAC TGCTGCTGGA TAAGAAGTAT GCACTGCCTT ACCGGGTGCT GGATGCCCTA 
GTCTTCCACT TCCTGGGGTT CCGGACAGAG AAGCGTGAAC TGCCTGTGCT GTGGCACCAG 
TGCCTCCTGA CTTTGGTCCA GCGCTACAAG GCCGACTTGG CCACAGACCA GAAAGAGGCC 
CTCTTAGAAC TGCTCCGGCT GCAGCCCCAT CCACAGCTAT CGCCCGAAAT CAGGCGTGAG 
CTTCAGAGTG CAGTCCCCCG CGATGTGGAA GATGTTCCCA TCACCGTGGA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004044.3
CDS	337..1650
Translation	MPKFKAARGVGGQEKHAPLADQILAGNAVRAGVREKRRGRGTGEAEEEYVGPRLSRRILQQARQQQEELEAEHGTGDKPAAPRERTTRLGPRMPQDGSDDEDEEWPTLEKAATMTAAGHHAEVVVDPEDERAIEMFMNKNPPARRTLADIIMEKLTEKQTEVETVMSEVSGFPMPQLDPRVLEVYRGVREVLSKYRSGKLPKAFKIIPALSNWEQILYVTEPEAWTAAAMYQATRIFASNLKERMAQRFYNLVLLPRVRDDVAEYKRLNFHLYMALKKALFKPGAWFKGILIPLCESGTCTLREAIIVGSIITKCSIPVLHSSAAMLKIAEMEYSGANSIFLRLLLDKKYALPYRVLDALVFHFLGFRTEKRELPVLWHQCLLTLVQRYKADLATDQKEALLELLRLQPHPQLSPEIRRELQSAVPRDVEDVPITVE

Target ORF information:

RefSeq Version	NM_004053.3
Organism	Homo sapiens(human)
Definition	Homo sapiens bystin like (BYSL), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004053.3

ORF Insert Sequence:

ATGCCCAAAT TCAAGGCGGC CCGTGGGGTG GGGGGTCAGG AAAAACATGC GCCCCTGGCC 
GATCAGATCC TGGCTGGGAA TGCGGTGCGG GCGGGGGTCC GGGAGAAGCG GCGGGGTCGC 
GGGACAGGAG AAGCGGAGGA AGAGTATGTG GGGCCCCGGC TGAGCCGACG GATTTTGCAG 
CAAGCACGGC AGCAACAGGA GGAACTCGAG GCCGAGCATG GGACTGGGGA CAAGCCCGCG 
GCGCCGCGGG AACGCACCAC GCGGCTGGGT CCAAGAATGC CTCAGGATGG ATCAGATGAC 
GAGGACGAGG AGTGGCCCAC CCTGGAGAAG GCTGCCACAA TGACAGCAGC GGGCCATCAT 
GCAGAGGTGG TTGTGGACCC TGAGGATGAG CGTGCCATAG AGATGTTCAT GAACAAGAAC 
CCTCCTGCCA GGCGCACCCT GGCTGACATC ATCATGGAGA AGCTGACTGA GAAGCAGACA 
GAGGTTGAGA CAGTCATGTC AGAGGTGTCG GGCTTCCCTA TGCCCCAGCT GGACCCCCGG 
GTCCTAGAAG TGTACAGGGG GGTCCGGGAG GTATTATCTA AGTACCGCAG TGGAAAACTG 
CCCAAGGCAT TTAAGATCAT CCCTGCACTC TCCAACTGGG AGCAAATCCT CTACGTCACA 
GAGCCGGAGG CCTGGACTGC AGCTGCCATG TACCAGGCCA CCAGGATTTT TGCCTCTAAC 
CTGAAGGAAC GCATGGCCCA GCGCTTCTAC AACCTTGTCC TGCTCCCTCG AGTACGAGAT 
GACGTTGCTG AATACAAACG ACTCAACTTC CATCTCTACA TGGCTCTCAA GAAGGCCCTT 
TTCAAACCTG GAGCCTGGTT CAAAGGGATC CTGATTCCAC TGTGCGAGTC TGGCACTTGT 
ACCCTCCGGG AAGCCATCAT TGTGGGTAGC ATCATCACCA AGTGCTCCAT CCCTGTGTTG 
CACTCCAGTG CGGCCATGCT GAAAATTGCT GAGATGGAAT ACAGCGGTGC CAACAGCATC 
TTCCTGCGAC TGCTGCTGGA TAAGAAGTAT GCACTGCCTT ACCGGGTGCT GGATGCCCTA 
GTCTTCCACT TCCTGGGGTT CCGGACAGAG AAGCGTGAAC TGCCTGTGCT GTGGCACCAG 
TGCCTCCTGA CTTTGGTCCA GCGCTACAAG GCCGACTTGG CCACAGACCA GAAAGAGGCC 
CTCTTAGAAC TGCTCCGGCT GCAGCCCCAT CCACAGCTAT CGCCCGAAAT CAGGCGTGAG 
CTTCAGAGTG CAGTCCCCCG CGATGTGGAA GATGTTCCCA TCACCGTGGA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BYSL ( NM_004053.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004044.3 Homo sapiens bystin like (BYSL), mRNA.

Price & Availability↑

CloneID	OHu16171
Clone ID Related Accession (Same CDS sequence)	NM_004053.3 , NM_004053.4
Accession Version	NM_004053.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1314bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Homo sapiens(human)
Product	bystin
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC062627.1, BC007340.2 and BC050645.1. On Nov 23, 2018 this sequence version replaced NM_004053.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC007340.2, SRR3476690.380103.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000230340.9/ ENSP00000230340.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCCAAAT TCAAGGCGGC CCGTGGGGTG GGGGGTCAGG AAAAACATGC GCCCCTGGCC 
GATCAGATCC TGGCTGGGAA TGCGGTGCGG GCGGGGGTCC GGGAGAAGCG GCGGGGTCGC 
GGGACAGGAG AAGCGGAGGA AGAGTATGTG GGGCCCCGGC TGAGCCGACG GATTTTGCAG 
CAAGCACGGC AGCAACAGGA GGAACTCGAG GCCGAGCATG GGACTGGGGA CAAGCCCGCG 
GCGCCGCGGG AACGCACCAC GCGGCTGGGT CCAAGAATGC CTCAGGATGG ATCAGATGAC 
GAGGACGAGG AGTGGCCCAC CCTGGAGAAG GCTGCCACAA TGACAGCAGC GGGCCATCAT 
GCAGAGGTGG TTGTGGACCC TGAGGATGAG CGTGCCATAG AGATGTTCAT GAACAAGAAC 
CCTCCTGCCA GGCGCACCCT GGCTGACATC ATCATGGAGA AGCTGACTGA GAAGCAGACA 
GAGGTTGAGA CAGTCATGTC AGAGGTGTCG GGCTTCCCTA TGCCCCAGCT GGACCCCCGG 
GTCCTAGAAG TGTACAGGGG GGTCCGGGAG GTATTATCTA AGTACCGCAG TGGAAAACTG 
CCCAAGGCAT TTAAGATCAT CCCTGCACTC TCCAACTGGG AGCAAATCCT CTACGTCACA 
GAGCCGGAGG CCTGGACTGC AGCTGCCATG TACCAGGCCA CCAGGATTTT TGCCTCTAAC 
CTGAAGGAAC GCATGGCCCA GCGCTTCTAC AACCTTGTCC TGCTCCCTCG AGTACGAGAT 
GACGTTGCTG AATACAAACG ACTCAACTTC CATCTCTACA TGGCTCTCAA GAAGGCCCTT 
TTCAAACCTG GAGCCTGGTT CAAAGGGATC CTGATTCCAC TGTGCGAGTC TGGCACTTGT 
ACCCTCCGGG AAGCCATCAT TGTGGGTAGC ATCATCACCA AGTGCTCCAT CCCTGTGTTG 
CACTCCAGTG CGGCCATGCT GAAAATTGCT GAGATGGAAT ACAGCGGTGC CAACAGCATC 
TTCCTGCGAC TGCTGCTGGA TAAGAAGTAT GCACTGCCTT ACCGGGTGCT GGATGCCCTA 
GTCTTCCACT TCCTGGGGTT CCGGACAGAG AAGCGTGAAC TGCCTGTGCT GTGGCACCAG 
TGCCTCCTGA CTTTGGTCCA GCGCTACAAG GCCGACTTGG CCACAGACCA GAAAGAGGCC 
CTCTTAGAAC TGCTCCGGCT GCAGCCCCAT CCACAGCTAT CGCCCGAAAT CAGGCGTGAG 
CTTCAGAGTG CAGTCCCCCG CGATGTGGAA GATGTTCCCA TCACCGTGGA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004044.3
CDS	65..1378
Translation	MPKFKAARGVGGQEKHAPLADQILAGNAVRAGVREKRRGRGTGEAEEEYVGPRLSRRILQQARQQQEELEAEHGTGDKPAAPRERTTRLGPRMPQDGSDDEDEEWPTLEKAATMTAAGHHAEVVVDPEDERAIEMFMNKNPPARRTLADIIMEKLTEKQTEVETVMSEVSGFPMPQLDPRVLEVYRGVREVLSKYRSGKLPKAFKIIPALSNWEQILYVTEPEAWTAAAMYQATRIFASNLKERMAQRFYNLVLLPRVRDDVAEYKRLNFHLYMALKKALFKPGAWFKGILIPLCESGTCTLREAIIVGSIITKCSIPVLHSSAAMLKIAEMEYSGANSIFLRLLLDKKYALPYRVLDALVFHFLGFRTEKRELPVLWHQCLLTLVQRYKADLATDQKEALLELLRLQPHPQLSPEIRRELQSAVPRDVEDVPITVE

Target ORF information:

RefSeq Version	NM_004053.4
Organism	Homo sapiens(human)
Definition	Homo sapiens bystin like (BYSL), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004053.4

ORF Insert Sequence:

ATGCCCAAAT TCAAGGCGGC CCGTGGGGTG GGGGGTCAGG AAAAACATGC GCCCCTGGCC 
GATCAGATCC TGGCTGGGAA TGCGGTGCGG GCGGGGGTCC GGGAGAAGCG GCGGGGTCGC 
GGGACAGGAG AAGCGGAGGA AGAGTATGTG GGGCCCCGGC TGAGCCGACG GATTTTGCAG 
CAAGCACGGC AGCAACAGGA GGAACTCGAG GCCGAGCATG GGACTGGGGA CAAGCCCGCG 
GCGCCGCGGG AACGCACCAC GCGGCTGGGT CCAAGAATGC CTCAGGATGG ATCAGATGAC 
GAGGACGAGG AGTGGCCCAC CCTGGAGAAG GCTGCCACAA TGACAGCAGC GGGCCATCAT 
GCAGAGGTGG TTGTGGACCC TGAGGATGAG CGTGCCATAG AGATGTTCAT GAACAAGAAC 
CCTCCTGCCA GGCGCACCCT GGCTGACATC ATCATGGAGA AGCTGACTGA GAAGCAGACA 
GAGGTTGAGA CAGTCATGTC AGAGGTGTCG GGCTTCCCTA TGCCCCAGCT GGACCCCCGG 
GTCCTAGAAG TGTACAGGGG GGTCCGGGAG GTATTATCTA AGTACCGCAG TGGAAAACTG 
CCCAAGGCAT TTAAGATCAT CCCTGCACTC TCCAACTGGG AGCAAATCCT CTACGTCACA 
GAGCCGGAGG CCTGGACTGC AGCTGCCATG TACCAGGCCA CCAGGATTTT TGCCTCTAAC 
CTGAAGGAAC GCATGGCCCA GCGCTTCTAC AACCTTGTCC TGCTCCCTCG AGTACGAGAT 
GACGTTGCTG AATACAAACG ACTCAACTTC CATCTCTACA TGGCTCTCAA GAAGGCCCTT 
TTCAAACCTG GAGCCTGGTT CAAAGGGATC CTGATTCCAC TGTGCGAGTC TGGCACTTGT 
ACCCTCCGGG AAGCCATCAT TGTGGGTAGC ATCATCACCA AGTGCTCCAT CCCTGTGTTG 
CACTCCAGTG CGGCCATGCT GAAAATTGCT GAGATGGAAT ACAGCGGTGC CAACAGCATC 
TTCCTGCGAC TGCTGCTGGA TAAGAAGTAT GCACTGCCTT ACCGGGTGCT GGATGCCCTA 
GTCTTCCACT TCCTGGGGTT CCGGACAGAG AAGCGTGAAC TGCCTGTGCT GTGGCACCAG 
TGCCTCCTGA CTTTGGTCCA GCGCTACAAG GCCGACTTGG CCACAGACCA GAAAGAGGCC 
CTCTTAGAAC TGCTCCGGCT GCAGCCCCAT CCACAGCTAT CGCCCGAAAT CAGGCGTGAG 
CTTCAGAGTG CAGTCCCCCG CGATGTGGAA GATGTTCCCA TCACCGTGGA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
Molecular systems biology12(4)863(2016 Apr)
Yachie N,Petsalaki E,Mellor JC,Weile J,Jacob Y,Verby M,Ozturk SB,Li S,Cote AG,Mosca R,Knapp JJ,Ko M,Yu A,Gebbia M,Sahni N,Yi S,Tyagi T,Sheykhkarimli D,Roth JF,Wong C,Musa L,Snider J,Liu YC,Yu H,Braun P,Stagljar I,Hao T,Calderwood MA,Pelletier L,Aloy P,Hill DE,Vidal M,Roth FP

Genome-wide RNAi Screening Identifies Protein Modules Required for 40S Subunit Synthesis in Human Cells.
Cell reports13(12)2879-91(2015 Dec)
Badertscher L,Wild T,Montellese C,Alexander LT,Bammert L,Sarazova M,Stebler M,Csucs G,Mayer TU,Zamboni N,Zemp I,Horvath P,Kutay U

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
Nature514(7520)92-97(2014 Oct)
Perry JR,Day F,Elks CE,Sulem P,Thompson DJ,Ferreira T,He C,Chasman DI,Esko T,Thorleifsson G,Albrecht E,Ang WQ,Corre T,Cousminer DL,Feenstra B,Franceschini N,Ganna A,Johnson AD,Kjellqvist S,Lunetta KL,McMahon G,Nolte IM,Paternoster L,Porcu E,Smith AV,Stolk L,Teumer A,T?ernikova N,Tikkanen E,Ulivi S,Wagner EK,Amin N,Bierut LJ,Byrne EM,Hottenga JJ,Koller DL,Mangino M,Pers TH,Yerges-Armstrong LM,Zhao JH,Andrulis IL,Anton-Culver H,Atsma F,Bandinelli S,Beckmann MW,Benitez J,Blomqvist C,Bojesen SE,Bolla MK,Bonanni B,Brauch H,Brenner H,Buring JE,Chang-Claude J,Chanock S,Chen J,Chenevix-Trench G,Coll?e JM,Couch FJ,Couper D,Coveillo AD,Cox A,Czene K,D'adamo AP,Smith GD,De Vivo I,Demerath EW,Dennis J,Devilee P,Dieffenbach AK,Dunning AM,Eiriksdottir G,Eriksson JG,Fasching PA,Ferrucci L,Flesch-Janys D,Flyger H,Foroud T,Franke L,Garcia ME,Garc?a-Closas M,Geller F,de Geus EE,Giles GG,Gudbjartsson DF,Gudnason V,Gu?nel P,Guo S,Hall P,Hamann U,Haring R,Hartman CA,Heath AC,Hofman A,Hooning MJ,Hopper JL,Hu FB,Hunter DJ,Karasik D,Kiel DP,Knight JA,Kosma VM,Kutalik Z,Lai S,Lambrechts D,Lindblom A,M?gi R,Magnusson PK,Mannermaa A,Martin NG,Masson G,McArdle PF,McArdle WL,Melbye M,Michailidou K,Mihailov E,Milani L,Milne RL,Nevanlinna H,Neven P,Nohr EA,Oldehinkel AJ,Oostra BA,Palotie A,Peacock M,Pedersen NL,Peterlongo P,Peto J,Pharoah PD,Postma DS,Pouta A,Pylk?s K,Radice P,Ring S,Rivadeneira F,Robino A,Rose LM,Rudolph A,Salomaa V,Sanna S,Schlessinger D,Schmidt MK,Southey MC,Sovio U,Stampfer MJ,St?ckl D,Storniolo AM,Timpson NJ,Tyrer J,Visser JA,Vollenweider P,V?lzke H,Waeber G,Waldenberger M,Wallaschofski H,Wang Q,Willemsen G,Winqvist R,Wolffenbuttel BH,Wright MJ,,,,,,,Boomsma DI,Econs MJ,Khaw KT,Loos RJ,McCarthy MI,Montgomery GW,Rice JP,Streeten EA,Thorsteinsdottir U,van Duijn CM,Alizadeh BZ,Bergmann S,Boerwinkle E,Boyd HA,Crisponi L,Gasparini P,Gieger C,Harris TB,Ingelsson E,J?rvelin MR,Kraft P,Lawlor D,Metspalu A,Pennell CE,Ridker PM,Snieder H,S?rensen TI,Spector TD,Strachan DP,Uitterlinden AG,Wareham NJ,Widen E,Zygmunt M,Murray A,Easton DF,Stefansson K,Murabito JM,Ong KK

GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children.
Human molecular genetics22(7)1457-64(2013 Apr)
Li J,Glessner JT,Zhang H,Hou C,Wei Z,Bradfield JP,Mentch FD,Guo Y,Kim C,Xia Q,Chiavacci RM,Thomas KA,Qiu H,Grant SF,Furth SL,Hakonarson H,Sleiman PM

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BYSL cDNA ORF clone, Homo sapiens(human)

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