TFF2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TFF2
Entrez Gene ID	7032
Full Name	trefoil factor 2
Synonyms	SML1,SP
General protein information	Preferred Names trefoil factor 2 Names trefoil factor 2 spasmolysin spasmolytic polypeptide spasmolytic protein 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 21 Map Location: 21q22.3
Summary	Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. The encoded protein inhibits gastric acid secretion. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008].
Disorder MIM:	182590

mRNA and Protein(s)

mRNA	Protein	Name
NM_005423.5	NP_005414.1	trefoil factor 2 precursor
NM_005423.4	NP_005414.1	trefoil factor 2 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	TFF2	NP_005414.1
Pan troglodytes (chimpanzee)	TFF2	XP_525480.2
Rattus norvegicus (Norway rat)	Tff2	NP_446296.1
	LOC714550	XP_001106255.1
Mus musculus (house mouse)	Tff2	NP_033389.2
Canis lupus familiaris (dog)	TFF2	NP_001002991.1
Bos taurus (cattle)	TFF2	NP_001076990.1

Gene Ontology
Bibliography

Related articles in PubMed

Serum TFF1 and TFF3 but not TFF2 are higher in women with breast cancer than in women without breast cancer.
Ishibashi Y, Ohtsu H, Ikemura M, Kikuchi Y, Niwa T, Nishioka K, Uchida Y, Miura H, Aikou S, Gunji T, Matsuhashi N, Ohmoto Y, Sasaki T, Seto Y, Ogawa T, Tada K, Nomura S
Scientific reports7(1)4846(2017 Jul)

Increased trefoil factor 2 levels in patients with chronic kidney disease.
Lebherz-Eichinger D, Tudor B, Ankersmit HJ, Reiter T, Haas M, Einwallner E, Roth-Walter F, Krenn CG, Roth GA
PloS one12(3)e0174551(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that trefoil factor 2 (TFF2( urine levels continuously decreased with disease progression, TFF2 serum concentrations progressively increased from the early to later chronic kidney disease (CKD) stages, indicating changes in renal function and offering the potential to examine the course of CKD.
Title: Increased trefoil factor 2 levels in patients with chronic kidney disease.

this work reveals that TFF2 has tumor-suppressor activity, which may, in part, be regulated by SMAD4.
Title: Loss of Trefoil Factor 2 From Pancreatic Duct Glands Promotes Formation of Intraductal Papillary Mucinous Neoplasms in Mice.

Data indicate that the antitumor activity of trefoil factor 2 (TFF2) is mediated by an interaction with the transcription factor Sp3 (Sp3) in gastric cancer cells.
Title: Trefoil factor family 2 expression inhibits gastric cancer cell growth and invasion in?vitro via interactions with the transcription factor Sp3.

Data show the important functions of TFF2 in the gastric mucus barrier, mucus epithelia, immune system, central nervous system, and during fertilization. It has been shown to interact with the gastric mucin MUC6. [Review]
Title: TFF2, a MUC6-binding lectin stabilizing the gastric mucus barrier and more (Review).

These findings suggest that the rs184432 and rs225359 polymorphisms in TFF1 have protective effects for GC and contribute to the development of GC in Korean individuals.
Title: Association between Promoter Polymorphisms of TFF1, TFF2, and TFF3 and the Risk of Gastric and Diffuse Gastric Cancers in a Korean Population.

The following TFF2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TFF2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu15792	NM_005423.5 Latest version!	Homo sapiens trefoil factor 2 (TFF2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu15792	NM_005423.4	Homo sapiens trefoil factor 2 (TFF2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TFF2 ( NM_005423.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_005414.1 Homo sapiens trefoil factor 2 (TFF2), mRNA.

Price & Availability↑

CloneID	OHu15792
Clone ID Related Accession (Same CDS sequence)	NM_005423.5 , NM_005423.4
Accession Version	NM_005423.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 390bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	trefoil factor 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AA307808.1, BC032820.1 and BM853946.1. On Nov 23, 2018 this sequence version replaced NM_005423.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BP341913.1, BM853946.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142586, SAMEA2153946 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000291526.5/ ENSP00000291526.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGACGGC GAGACGCCCA GCTCCTGGCA GCGCTCCTCG TCCTGGGGCT ATGTGCCCTG 
GCGGGGAGTG AGAAACCCTC CCCCTGCCAG TGCTCCAGGC TGAGCCCCCA TAACAGGACG 
AACTGCGGCT TCCCTGGAAT CACCAGTGAC CAGTGTTTTG ACAATGGATG CTGTTTCGAC 
TCCAGTGTCA CTGGGGTCCC CTGGTGTTTC CACCCCCTCC CAAAGCAAGA GTCGGATCAG 
TGCGTCATGG AGGTCTCAGA CCGAAGAAAC TGTGGCTACC CGGGCATCAG CCCCGAGGAA 
TGCGCCTCTC GGAAGTGCTG CTTCTCCAAC TTCATCTTTG AAGTGCCCTG GTGCTTCTTC 
CCGAAGTCTG TGGAAGACTG CCATTACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005414.1
CDS	38..427
Translation	MGRRDAQLLAALLVLGLCALAGSEKPSPCQCSRLSPHNRTNCGFPGITSDQCFDNGCCFDSSVTGVPWCFHPLPKQESDQCVMEVSDRRNCGYPGISPEECASRKCCFSNFIFEVPWCFFPKSVEDCHY

Target ORF information:

RefSeq Version	NM_005423.5
Organism	Homo sapiens(human)
Definition	Homo sapiens trefoil factor 2 (TFF2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005423.5

ORF Insert Sequence:

ATGGGACGGC GAGACGCCCA GCTCCTGGCA GCGCTCCTCG TCCTGGGGCT ATGTGCCCTG 
GCGGGGAGTG AGAAACCCTC CCCCTGCCAG TGCTCCAGGC TGAGCCCCCA TAACAGGACG 
AACTGCGGCT TCCCTGGAAT CACCAGTGAC CAGTGTTTTG ACAATGGATG CTGTTTCGAC 
TCCAGTGTCA CTGGGGTCCC CTGGTGTTTC CACCCCCTCC CAAAGCAAGA GTCGGATCAG 
TGCGTCATGG AGGTCTCAGA CCGAAGAAAC TGTGGCTACC CGGGCATCAG CCCCGAGGAA 
TGCGCCTCTC GGAAGTGCTG CTTCTCCAAC TTCATCTTTG AAGTGCCCTG GTGCTTCTTC 
CCGAAGTCTG TGGAAGACTG CCATTACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TFF2 ( NM_005423.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005414.1 Homo sapiens trefoil factor 2 (TFF2), mRNA.

Price & Availability↑

CloneID	OHu15792
Clone ID Related Accession (Same CDS sequence)	NM_005423.5 , NM_005423.4
Accession Version	NM_005423.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 390bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-10
Organism	Homo sapiens(human)
Product	trefoil factor 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AA307808.1, BC032820.1 and BM853946.1. On Aug 1, 2008 this sequence version replaced NM_005423.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BM853946.1, BM853896.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142586, SAMEA2153946 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGACGGC GAGACGCCCA GCTCCTGGCA GCGCTCCTCG TCCTGGGGCT ATGTGCCCTG 
GCGGGGAGTG AGAAACCCTC CCCCTGCCAG TGCTCCAGGC TGAGCCCCCA TAACAGGACG 
AACTGCGGCT TCCCTGGAAT CACCAGTGAC CAGTGTTTTG ACAATGGATG CTGTTTCGAC 
TCCAGTGTCA CTGGGGTCCC CTGGTGTTTC CACCCCCTCC CAAAGCAAGA GTCGGATCAG 
TGCGTCATGG AGGTCTCAGA CCGAAGAAAC TGTGGCTACC CGGGCATCAG CCCCGAGGAA 
TGCGCCTCTC GGAAGTGCTG CTTCTCCAAC TTCATCTTTG AAGTGCCCTG GTGCTTCTTC 
CCGAAGTCTG TGGAAGACTG CCATTACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005414.1
CDS	143..532
Translation	MGRRDAQLLAALLVLGLCALAGSEKPSPCQCSRLSPHNRTNCGFPGITSDQCFDNGCCFDSSVTGVPWCFHPLPKQESDQCVMEVSDRRNCGYPGISPEECASRKCCFSNFIFEVPWCFFPKSVEDCHY

Target ORF information:

RefSeq Version	NM_005423.4
Organism	Homo sapiens(human)
Definition	Homo sapiens trefoil factor 2 (TFF2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005423.4

ORF Insert Sequence:

ATGGGACGGC GAGACGCCCA GCTCCTGGCA GCGCTCCTCG TCCTGGGGCT ATGTGCCCTG 
GCGGGGAGTG AGAAACCCTC CCCCTGCCAG TGCTCCAGGC TGAGCCCCCA TAACAGGACG 
AACTGCGGCT TCCCTGGAAT CACCAGTGAC CAGTGTTTTG ACAATGGATG CTGTTTCGAC 
TCCAGTGTCA CTGGGGTCCC CTGGTGTTTC CACCCCCTCC CAAAGCAAGA GTCGGATCAG 
TGCGTCATGG AGGTCTCAGA CCGAAGAAAC TGTGGCTACC CGGGCATCAG CCCCGAGGAA 
TGCGCCTCTC GGAAGTGCTG CTTCTCCAAC TTCATCTTTG AAGTGCCCTG GTGCTTCTTC 
CCGAAGTCTG TGGAAGACTG CCATTACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Serum TFF1 and TFF3 but not TFF2 are higher in women with breast cancer than in women without breast cancer.
Scientific reports7(1)4846(2017 Jul)
Ishibashi Y,Ohtsu H,Ikemura M,Kikuchi Y,Niwa T,Nishioka K,Uchida Y,Miura H,Aikou S,Gunji T,Matsuhashi N,Ohmoto Y,Sasaki T,Seto Y,Ogawa T,Tada K,Nomura S

Increased trefoil factor 2 levels in patients with chronic kidney disease.
PloS one12(3)e0174551(2017)
Lebherz-Eichinger D,Tudor B,Ankersmit HJ,Reiter T,Haas M,Einwallner E,Roth-Walter F,Krenn CG,Roth GA

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TFF2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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