TECTA cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TECTA
Entrez Gene ID	7007
Full Name	tectorin alpha
Synonyms	DFNA12,DFNA8,DFNB21
General protein information	Preferred Names tectorin alpha Names alpha-tectorin
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q23.3
Summary	The tectorial membrane is an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. Alpha-tectorin is one of the major noncollagenous components of the tectorial membrane. Mutations in the TECTA gene have been shown to be responsible for autosomal dominant nonsyndromic hearing impairment and a recessive form of sensorineural pre-lingual non-syndromic deafness. [provided by RefSeq, Jul 2008].
Disorder MIM:	602574
Disorder Html:	Deafness, autosomal dominant 8/12, 601543 (3); Deafness, autosomal recessive 21, 603629 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_005422.2	NP_005413.2	alpha-tectorin precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	TECTA	XP_546475.2
Gallus gallus (chicken)	TECTA	XP_004948075.1
Homo sapiens (human)	TECTA	NP_005413.2
Xenopus tropicalis (tropical clawed frog)	LOC100490936	XP_002935069.2
Danio rerio (zebrafish)	LOC561355	XP_689855.5
Mus musculus (house mouse)	Tecta	NP_033373.2
Pan troglodytes (chimpanzee)	TECTA	XP_508823.2
Bos taurus (cattle)	TECTA	XP_003586997.1
Rattus norvegicus (Norway rat)	Tecta	NP_001100284.1

Gene Ontology
Bibliography

Related articles in PubMed

Prevalence of TECTA mutation in patients with mid-frequency sensorineural hearing loss.
Yamamoto N, Mutai H, Namba K, Morita N, Masuda S, Nishi Y, Nakano A, Masuda S, Fujioka M, Kaga K, Ogawa K, Matsunaga T
Orphanet journal of rare diseases12(1)157(2017 Sep)

A novel TECTA mutation causes ARNSHL.
Asgharzade S, Tabatabaiefar MA, Modarressi MH, Ghahremani MH, Reiisi S, Tahmasebi P, Abdollahnejad F, Chaleshtori MH
International journal of pediatric otorhinolaryngology9288-93(2017 Jan)

A novel biallelic splice site mutation of TECTA causes moderate to severe hearing impairment in an Algerian family.
Behlouli A, Bonnet C, Abdi S, Hasbellaoui M, Boudjenah F, Hardelin JP, Louha M, Makrelouf M, Ammar-Khodja F, Zenati A, Petit C
International journal of pediatric otorhinolaryngology8728-33(2016 Aug)

Research progress in pathogenic genes of hereditary non-syndromic mid-frequency deafness.
Xia W, Liu F, Ma D
Frontiers of medicine10(2)137-42(2016 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A novel homozygous variant (c.734G > A) was found in exon 5 of the TECTA gene in one family leading to a nonsense mutation causing autosomal recessive nonsyndromic hearing loss.
Title: A novel TECTA mutation causes ARNSHL.

To our knowledge, this is the first reported TECTA mutation leading to the DFNB21 form of hearing impairment among Maghrebian individuals suffering from congenital hearing impairment
Title: A novel biallelic splice site mutation of TECTA causes moderate to severe hearing impairment in an Algerian family.

Up to now, merely 7 loci have been linked to mid-frequency hearing loss. Only four genetic mid-frequency deafness genes, namely, DFNA10 (EYA4), DFNA8/12 (TECTA), DFNA13 (COL11A2), DFNA44 (CCDC50), have been reported to date. [review]
Title: Research progress in pathogenic genes of hereditary non-syndromic mid-frequency deafness.

Here we confirm a known genotype-phenotype correlation for the ZP domain and propose a hypothetical genotype-phenotype correlation which relates mutations in vWFD3-D4 to stable high-frequency NSHL in Koreans.
Title: Novel TECTA mutations identified in stable sensorineural hearing loss and their clinical implications.

the present report suggest that the association of RWDD3 and TECTA with paclitaxel-induced peripheral neuropathy may have been a false positive signal
Title: RWDD3 and TECTA variants not linked to paclitaxel induced peripheral neuropathy in North American trial Alliance N08C1.

The following TECTA gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TECTA cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu25746	NM_005422.2 Latest version!	Homo sapiens tectorin alpha (TECTA), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	30	$923.30 $1319.00

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TECTA ( NM_005422.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_005413.2 Homo sapiens tectorin alpha (TECTA), mRNA.

Price & Availability↑

CloneID	OHu25746
Clone ID Related Accession (Same CDS sequence)	NM_005422.2
Accession Version	NM_005422.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 6468bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-02
Organism	Homo sapiens(human)
Product	alpha-tectorin precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP000646.4 and AP000826.5. This sequence is a reference standard in the RefSeqGene project. On Mar 29, 2007 this sequence version replaced NM_005422.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA2161674 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGAATTATT CATCATTCCT TAGAATTTGG GTCTCTTTCA TCTTCGCACT TGTACAGCAC 
CAAGCTCAGC CCAGGGAGCT CATGTATCCA TTTTGGCAGA ATGACACCAA AACCCCTAAA 
GTAGATGATG GAAGCTCATC TGAGATTAAG TTGGCCATCC CAGTTTTCTT CTTTGGCGTT 
CCTTACCGCA CTGTCTATGT CAATAACAAC GGAGTTGTTT CCTTCAATGT GCTAGTGAGC 
CAGTTCACGC CAGAATCCTT TCCCCTGACA GATGGGAGAG CCTTCGTCGC CCCATTTTGG 
GCAGATGTGC ACAATGGAAT TCGAGGCGAG ATCTATTACA GAGAGACCAT GGAGCCTGCC 
ATCTTGAAAA GAGCCACCAA GGACATCAGG AAGTACTTCA AAGACATGGC AACCTTCTCT 
GCCACTTGGG TTTTCATTGT GACATGGGAG GAAGTCACGT TTTATGGAGG CAGCAGCACC 
ACACCTGTGA ACACCTTCCA GGCCGTCCTA GTGTCCGATG GCTCCTATAC ATTCACCCTC 
TTCAATTATT ACGAAATCAA CTGGACCACG GGGACGGCGA GTGGCGGCGA CCCCCTGACA 
GGTCTTGGTG GAGTGATGGC ACAGGCAGGA TTTAATGGTG GAAACCTCAC CAATTTCTTC 
AGCCTCCCGG GGTCAAGAAC CCCCGAGATC GTGAATATCC AGGAGACCAC AAACGTCAAT 
GTTCCAGGCC GCTGGGCATT TAAAGTTGAT GGAAAGGAAA TTGACCCAGC CAATGGCTGC 
ACCTCAAGGG GACAATTCCT TCGGCGAGGG GAGGTGTTTT GGGATGACTT GAACTGCACC 
GTCAAGTGCC GCTGTCTGGA TTTCAACAAT GAGATCTACT GCCAGGAGGC TTCCTGTAGC 
CCCTACGAGG TGTGCGAACC CAAAGGCAAA TTCTTCTACT GCAGCGCTGT GGAGACCAGC 
ACATGCGTGG TGTTTGGGGA GCCACACTAC CACACTTTTG ACGGCTTCCT CTTCCACTTC 
CAAGGCTCCT GTGCCTACTT GCTGGCCCGA CAGTGTTTGC AGACTTCCAG CCTCCCTTTC 
TTCAGTGTGG AGGCCAAGAA TGAACACCGC AGAGGTTCAG CCGTCTCCTG GGTGAAGGAG 
CTCTCAGTGG AGGTGAATGG CTACAAGATT CTCATCCCCA AAGGAAGCTA TGGAAGAGTC 
AAGGTTAATG ACCTAGTGAC TTCTTTGCCT GTCACCTTAG ACTTGGGGAC AGTGAAAATC 
TACCAGAGTG GCATATCTAC TGCCGTGGAA ACAGATTTTG GGCTCTTAGT GACTTTTGAT 
GGCCAGCACT ACGCCTCCAT TTCCGTCCCA GGCTCCTATA TAAACTCCAC CTGTGGACTC 
TGTGGAAACT ATAATAAAAA CCCACTGGAT GACTTCCTCC GCCCGGATGG CAGGCCGGCC 
ATGTCTGTCC TGGATCTGGG AGAGAGCTGG CGTGTGTACC ACGCAGACTG GAAGTGCGAC 
TCCGGCTGCG TCGACAACTG CACCCAGTGC GACGCTGCCA CTGAAGCCCT CTACTTTGGC 
TCTGACTACT GCGGCTTCCT CAACAAGACA GACGGCCCTC TGTGGGAGTG TGGCACTGTC 
GTGGACCCCA CTGCTTTTGT GCACAGCTGC GTGTATGACC TGTGCAGTGT GAGGGACAAT 
GGCACGCTCC TCTGCCAAGC CATCCAGGCC TATGCTCTTG TGTGCCAAGC CCTTGGCATT 
CCAATTGGAG ACTGGCGAAC CCAGACTGGG TGTGTGTCCA CAGTGCAGTG CCCGAGCTTC 
AGCCACTACT CCGTGTGCAC AAGCAGCTGC CCCGACACAT GCTCCGACCT GACGGCCTCG 
CGGAACTGCG CCACGCCGTG CACAGAGGGC TGCGAGTGCA ACCAGGGCTT CGTCCTCAGC 
ACCAGCCAGT GCGTCCCTCT GCACAAGTGC GGCTGCGACT TCGACGGCCA CTACTACACC 
ATGGGGGAGT TCTTCTGGGC CACGGCCAAC TGCACTGTGC AATGCCTGTG CGAGGAGGGC 
GGGGACGTCT ACTGCTTCAA CAAGACCTGC GGCAGCGGGG AGGTGTGCGC CGTGGAGGAC 
GGCTACCAGG GCTGCTTCCC CAAGCGGGAG ACCGTGTGCC TGCTCAGCCA GAACCAGGTG 
CTGCACACCT TTGACGGCGC CTCCTACGCC TTCCCCTCCG AGTTCTCCTA CACCCTCCTG 
AAGACCTGCC CTGAGCGCCC AGAGTACTTG GAAATCGACA TCAACAAGAA GAAGCCCGAT 
GCAGGACCTG CTTGGCTGCG GGGACTTCGG ATCCTGGTGG CCGACCAGGA GGTCAAGATA 
GGAGGCATCG GGGCTTCGGA AGTCAAGTTG AATGGTCAGG AAGTGGAATT GCCTTTTTTC 
CATCCTTCGG GGAAGCTGGA AATTTATCGA AACAAAAACA GTACGACAGT GGAGTCCAAG 
GGCGTGGTGA CTGTCCAGTA CTCAGACATA GGTCTATTGT ACATCCGGCT GTCCACCACA 
TACTTCAATT GCACAGGGGG CTTGTGCGGC TTCTACAATG CCAACGCCAG TGACGAGTTC 
TGTCTCCCCA ACGGCAAGTG CACGGACAAC CTGGCAGTGT TCCTGGAAAG CTGGACAACT 
TTCGAGGAGA TCTGCAATGG AGAGTGTGGG GACCTGCTGA AGGCCTGCAA CAATGACTCG 
GAGCTGCTCA AGTTTTATCG AAGCCGCTCC AGGTGCGGCA TCATCAACGA CCCCTCCAAC 
AGCTCCTTCC TGGAGTGCCA TGGGGTGGTG AACGTCACTG CCTATTACCG CACCTGCCTT 
TTCCGCCTGT GCCAGAGTGG GGGCAATGAG TCAGAGCTCT GTGACTCTGT GGCCCGGTAT 
GCAAGCGCCT GCAAGAATGC GGACGTGGAG GTGGGGCCCT GGCGGACCTA TGACTTCTGC 
CCACTGGAGT GCCCAGAGAA CAGCCACTTT GAGGAGTGCA TCACATGTAC AGAGACCTGT 
GAGACCCTTA CCCTGGGCCC CATCTGCGTG GATAGCTGCT CTGAGGGATG TCAGTGTGAT 
GAGGGCTATG CTCTACTGGG CAGCCAGTGT GTCACGCGGA GTGAGTGTGG CTGCAACTTT 
GAGGGGCACC AACTTGCCAC CAATGAGACC TTCTGGGTGG ACCTGGACTG CCAGATCTTC 
TGCTATTGCA GTGGCACAGA CAACAGGGTC CACTGCGAGA CCATTCCCTG CAAGGATGAT 
GAGTACTGCA TGGAGGAAGG TGGCCTGTAC TACTGCCAAG CCCGCACCGA CGCCTCCTGC 
ATCGTCTCAG GCTACGGCCA CTACCTCACC TTTGATGGCT TCCCCTTTGA CTTCCAGACC 
AGCTGCCCAC TCATCCTGTG CACCACAGGA AGCAGGCCAA GCTCAGACTC TTTCCCCAAG 
TTTGTTGTCA CAGCCAAGAA TGAGGACCGG GACCCGTCAC TGGCCTTGTG GGTTAAGCAG 
GTGGACGTGA CCGTGTTTGG CTACAGCATC GTGATCCACC GAGCTTACAA GCACACTGTG 
CTGGTCAACA GTGAACGGCT CTATCTGCCC CTGAAGCTGG GGCAAGGGAA GATAAATATC 
TTTTCCTTTG GCTTCCACGT GGTGGTGGAA ACTGATTTTG GCCTGAAGGT TGTATATGAC 
TGGAAGACCT TCCTGTCCAT CACAGTCCCT CGGAGCATGC AGAACAGCAC CTATGGTCTG 
TGTGGCCGCT ACAACGGCAA CCCTGATGAT GACCTGGAGA TGCCCATGGG TCTGCTTGCA 
TCGAGTGTCA ATGAGTTTGG GCAGAGCTGG GTGAAGAGGG ACACCTTCTG CCAGGTGGGC 
TGTGGGGACC GCTGTCCGTC CTGTGCCAAG GTGGAAGGTT TCTCCAAAGT GCAGCAGCTG 
TGCAGCCTGA TCCCCAACCA GAACGCTGCC TTCTCCAAGT GTCACAGCAA AGTTAACCCC 
ACCTTCTTCT ATAAGAACTG CCTGTTTGAC TCTTGCATCG ATGGGGGCGC GGTGCAGACC 
GCCTGCAGCT GGCTGCAGAA CTACGCCAGC ACCTGCCAGA CTCAGGGGAT TACGGTGACT 
GGCTGGAGGA ATTACACGTC CTGCACTGTC ACCTGCCCTC CAAACAGCCA TTACGAGAGC 
TGCGTGAGTG TCTGCCAGCC CCGCTGCGCC GCCATCCGCC TGAAGAGTGA CTGCAGCCAC 
TACTGCGTGG AGGGCTGTCA CTGCGACGCT GGCTACGTCC TCAACGGCAA GAGCTGCATC 
CTGCCCCACA GCTGCGGCTG CTACTCCGAT GGCAAATATT ACGAGCCCAA GCAGCTATTT 
TGGAACAGCG ACTGCACGCG GCGCTGCCGC TGTTTCCGTC GCAACGTGAT TCAGTGCGAC 
CCGCGCCAAT GCAAGTCAGA CGAGGAGTGT GCGCTGCGCA ACGGGGTGCG CGGCTGCTTC 
AGCACCAAGA CCTCCTACTG CCTGGCGGCC GGCGGCGGCG TCTTCCGCAC CTTCGACGGC 
GCCTTCCTGC GCTTCCCAGC CAACTGCGCC TTCGTGCTGT CCACCATCTG CCAGAAACTG 
CCCGACATCT CCTTCCAGCT TATCATCAAC TTCGACAAGT GGTCGGCCCC CAACCTCACC 
ATCATTTCGC CCGTCTACTT CTACATTAAC GAAGAGCAGA TTCTCATCAA CGACCGGAAC 
ACGGTCAAGG TGAATGGCAC ACAAGTGAAT GTTCCATTTA TAACTGGTTT GGCAACCAAA 
ATCTACAGCA GTGAGGGGTT TCTGGTGATT GACACCAGCC CAGACATCCA GATATACTAC 
AATGGTTTCA ACGTCATTAA AATCAGCATC AGCGAGAGGC TGCAGAACAA AGTGTGCGGT 
CTCTGTGGCA ACTTCAACGG GGACCTAACA GATGATTATG TGACCTTGCG AGGGAAGCCG 
GTGGTAAGCA GCGTGGTGCT GGCCCAGAGC TGGAAAACCA ATGGCATGCA GAAGAGACCT 
CTTGCCCCCA GCTGCAACGA GCTGCAGTTC TCACAGTATG CAGCCATGTG TGACAATGTG 
CACATCCAGA AGATGCAGGG TGATGGCTAC TGCCTGAAGC TCACCGACAT GAAGGGCTTC 
TTCCAGCCCT GCTATGGGCT TCTCGATCCC CTCCCATTCT ACGAGTCCTG CTACCTGGAC 
GGCTGCTACA GCCACAAGAA GTTCCAGCTG TGCGGCTCCC TGGCCGCCTA CGGGGAGGCC 
TGCCGCTCCT TCGGGATCCT TAGCACCGAG TGGATTGAGA AGGAGAATTG CTCAGGAGTG 
GTTGAAGATC CCTGTGTGGG GGCGGACTGT CCCAACCGAA CTTGCGAGCT GGGCAATGGC 
AGGGAGCTGT GTGGCTGCAT CGAGCCACCC CCCTATGGAA ATAACTCACA TGACATTATC 
GATGCAGAGG TGACCTGCAA AGCAGCCCAA ATGGAAGTGT CCATATCTAA GTGCAAGCTC 
TTCCAGCTCG GTTTTGAGAG GGAGGGCGTG AGGATCAATG ACAGACAGTG CACCGGCATC 
GAGGGGGAAG ATTTTATCTC CTTTCAGATC AACAACACCA AAGGGAATTG TGGAAACATT 
GTGCAGTCCA ATGGCACGCA TATCATGTAT AAAAACACAC TCTGGATCGA AAGCGCCAAC 
AACACTGGCA ACATCATCAC CAGGGACCGC ACGATCAATG TGGAATTTTC ATGTGCTTAT 
GAGCTGGATA TCAAGATCTC CTTGGATTCT GTTGTGAAGC CTATGCTAAG TGTAATTAAC 
CTGACAGTTC CAACCCAAGA AGGCAGCTTC ATCACCAAGA TGGCTCTCTA CAAAAACGCC 
TCCTACAAAC ATCCTTACCG CCAGGGTGAA GTAGTGTTGA CGACTCGAGA TGTGCTGTAT 
GTAGGGGTTT TTGTGGTTGG AGCTGACGCC ACACATTTAA TCCTAACACT CAACAAATGC 
TATGCCACAC CCACCCGAGA TAGCAATGAT AAGCTCCGAT ATTTCATCAT TGAAGGAGGG 
TGTCAGAACC TCAAAGATAA CACCATTGGC ATCGAGGAGA ATGCAGTCTC CCTGACCTGT 
CGCTTTCACG TCACCGTCTT TAAATTCATA GGGGATTACG ACGAAGTTCA CCTTCACTGT 
GCAGTGTCAC TCTGCGACTC AGAAAAGTAC TCCTGTAAAA TCACTTGCCC ACACAATTCC 
AGGATTGCCA CAGATTACAC AAAAGAGCCC AAAGAACAGA TCATTTCAGT GGGACCTATT 
AGGAGAAAAA GGCTGGACTG GTGTGAGGAC AATGGAGGGT GTGAGCAGAT TTGCACGAGC 
CGGGTGGATG GGCCTCTCTG CAGCTGTGTA ACAGGAACCC TGCAGGAGGA CGGCAAGAGC 
TGCAGAGCCT CTAATTCTTC AATGGAACTT CAAGTCTGGA CGCTTCTTCT CATCATGATC 
CAGATTTCAT TATGGCATTT TGTCTATAAA TCAGGCACGA CCTCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005413.2
CDS	1..6468
Translation	MNYSSFLRIWVSFIFALVQHQAQPRELMYPFWQNDTKTPKVDDGSSSEIKLAIPVFFFGVPYRTVYVNNNGVVSFNVLVSQFTPESFPLTDGRAFVAPFWADVHNGIRGEIYYRETMEPAILKRATKDIRKYFKDMATFSATWVFIVTWEEVTFYGGSSTTPVNTFQAVLVSDGSYTFTLFNYYEINWTTGTASGGDPLTGLGGVMAQAGFNGGNLTNFFSLPGSRTPEIVNIQETTNVNVPGRWAFKVDGKEIDPANGCTSRGQFLRRGEVFWDDLNCTVKCRCLDFNNEIYCQEASCSPYEVCEPKGKFFYCSAVETSTCVVFGEPHYHTFDGFLFHFQGSCAYLLARQCLQTSSLPFFSVEAKNEHRRGSAVSWVKELSVEVNGYKILIPKGSYGRVKVNDLVTSLPVTLDLGTVKIYQSGISTAVETDFGLLVTFDGQHYASISVPGSYINSTCGLCGNYNKNPLDDFLRPDGRPAMSVLDLGESWRVYHADWKCDSGCVDNCTQCDAATEALYFGSDYCGFLNKTDGPLWECGTVVDPTAFVHSCVYDLCSVRDNGTLLCQAIQAYALVCQALGIPIGDWRTQTGCVSTVQCPSFSHYSVCTSSCPDTCSDLTASRNCATPCTEGCECNQGFVLSTSQCVPLHKCGCDFDGHYYTMGEFFWATANCTVQCLCEEGGDVYCFNKTCGSGEVCAVEDGYQGCFPKRETVCLLSQNQVLHTFDGASYAFPSEFSYTLLKTCPERPEYLEIDINKKKPDAGPAWLRGLRILVADQEVKIGGIGASEVKLNGQEVELPFFHPSGKLEIYRNKNSTTVESKGVVTVQYSDIGLLYIRLSTTYFNCTGGLCGFYNANASDEFCLPNGKCTDNLAVFLESWTTFEEICNGECGDLLKACNNDSELLKFYRSRSRCGIINDPSNSSFLECHGVVNVTAYYRTCLFRLCQSGGNESELCDSVARYASACKNADVEVGPWRTYDFCPLECPENSHFEECITCTETCETLTLGPICVDSCSEGCQCDEGYALLGSQCVTRSECGCNFEGHQLATNETFWVDLDCQIFCYCSGTDNRVHCETIPCKDDEYCMEEGGLYYCQARTDASCIVSGYGHYLTFDGFPFDFQTSCPLILCTTGSRPSSDSFPKFVVTAKNEDRDPSLALWVKQVDVTVFGYSIVIHRAYKHTVLVNSERLYLPLKLGQGKINIFSFGFHVVVETDFGLKVVYDWKTFLSITVPRSMQNSTYGLCGRYNGNPDDDLEMPMGLLASSVNEFGQSWVKRDTFCQVGCGDRCPSCAKVEGFSKVQQLCSLIPNQNAAFSKCHSKVNPTFFYKNCLFDSCIDGGAVQTACSWLQNYASTCQTQGITVTGWRNYTSCTVTCPPNSHYESCVSVCQPRCAAIRLKSDCSHYCVEGCHCDAGYVLNGKSCILPHSCGCYSDGKYYEPKQLFWNSDCTRRCRCFRRNVIQCDPRQCKSDEECALRNGVRGCFSTKTSYCLAAGGGVFRTFDGAFLRFPANCAFVLSTICQKLPDISFQLIINFDKWSAPNLTIISPVYFYINEEQILINDRNTVKVNGTQVNVPFITGLATKIYSSEGFLVIDTSPDIQIYYNGFNVIKISISERLQNKVCGLCGNFNGDLTDDYVTLRGKPVVSSVVLAQSWKTNGMQKRPLAPSCNELQFSQYAAMCDNVHIQKMQGDGYCLKLTDMKGFFQPCYGLLDPLPFYESCYLDGCYSHKKFQLCGSLAAYGEACRSFGILSTEWIEKENCSGVVEDPCVGADCPNRTCELGNGRELCGCIEPPPYGNNSHDIIDAEVTCKAAQMEVSISKCKLFQLGFEREGVRINDRQCTGIEGEDFISFQINNTKGNCGNIVQSNGTHIMYKNTLWIESANNTGNIITRDRTINVEFSCAYELDIKISLDSVVKPMLSVINLTVPTQEGSFITKMALYKNASYKHPYRQGEVVLTTRDVLYVGVFVVGADATHLILTLNKCYATPTRDSNDKLRYFIIEGGCQNLKDNTIGIEENAVSLTCRFHVTVFKFIGDYDEVHLHCAVSLCDSEKYSCKITCPHNSRIATDYTKEPKEQIISVGPIRRKRLDWCEDNGGCEQICTSRVDGPLCSCVTGTLQEDGKSCRASNSSMELQVWTLLLIMIQISLWHFVYKSGTTS

Target ORF information:

RefSeq Version	NM_005422.2
Organism	Homo sapiens(human)
Definition	Homo sapiens tectorin alpha (TECTA), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005422.2

ORF Insert Sequence:

ATGAATTATT CATCATTCCT TAGAATTTGG GTCTCTTTCA TCTTCGCACT TGTACAGCAC 
CAAGCTCAGC CCAGGGAGCT CATGTATCCA TTTTGGCAGA ATGACACCAA AACCCCTAAA 
GTAGATGATG GAAGCTCATC TGAGATTAAG TTGGCCATCC CAGTTTTCTT CTTTGGCGTT 
CCTTACCGCA CTGTCTATGT CAATAACAAC GGAGTTGTTT CCTTCAATGT GCTAGTGAGC 
CAGTTCACGC CAGAATCCTT TCCCCTGACA GATGGGAGAG CCTTCGTCGC CCCATTTTGG 
GCAGATGTGC ACAATGGAAT TCGAGGCGAG ATCTATTACA GAGAGACCAT GGAGCCTGCC 
ATCTTGAAAA GAGCCACCAA GGACATCAGG AAGTACTTCA AAGACATGGC AACCTTCTCT 
GCCACTTGGG TTTTCATTGT GACATGGGAG GAAGTCACGT TTTATGGAGG CAGCAGCACC 
ACACCTGTGA ACACCTTCCA GGCCGTCCTA GTGTCCGATG GCTCCTATAC ATTCACCCTC 
TTCAATTATT ACGAAATCAA CTGGACCACG GGGACGGCGA GTGGCGGCGA CCCCCTGACA 
GGTCTTGGTG GAGTGATGGC ACAGGCAGGA TTTAATGGTG GAAACCTCAC CAATTTCTTC 
AGCCTCCCGG GGTCAAGAAC CCCCGAGATC GTGAATATCC AGGAGACCAC AAACGTCAAT 
GTTCCAGGCC GCTGGGCATT TAAAGTTGAT GGAAAGGAAA TTGACCCAGC CAATGGCTGC 
ACCTCAAGGG GACAATTCCT TCGGCGAGGG GAGGTGTTTT GGGATGACTT GAACTGCACC 
GTCAAGTGCC GCTGTCTGGA TTTCAACAAT GAGATCTACT GCCAGGAGGC TTCCTGTAGC 
CCCTACGAGG TGTGCGAACC CAAAGGCAAA TTCTTCTACT GCAGCGCTGT GGAGACCAGC 
ACATGCGTGG TGTTTGGGGA GCCACACTAC CACACTTTTG ACGGCTTCCT CTTCCACTTC 
CAAGGCTCCT GTGCCTACTT GCTGGCCCGA CAGTGTTTGC AGACTTCCAG CCTCCCTTTC 
TTCAGTGTGG AGGCCAAGAA TGAACACCGC AGAGGTTCAG CCGTCTCCTG GGTGAAGGAG 
CTCTCAGTGG AGGTGAATGG CTACAAGATT CTCATCCCCA AAGGAAGCTA TGGAAGAGTC 
AAGGTTAATG ACCTAGTGAC TTCTTTGCCT GTCACCTTAG ACTTGGGGAC AGTGAAAATC 
TACCAGAGTG GCATATCTAC TGCCGTGGAA ACAGATTTTG GGCTCTTAGT GACTTTTGAT 
GGCCAGCACT ACGCCTCCAT TTCCGTCCCA GGCTCCTATA TAAACTCCAC CTGTGGACTC 
TGTGGAAACT ATAATAAAAA CCCACTGGAT GACTTCCTCC GCCCGGATGG CAGGCCGGCC 
ATGTCTGTCC TGGATCTGGG AGAGAGCTGG CGTGTGTACC ACGCAGACTG GAAGTGCGAC 
TCCGGCTGCG TCGACAACTG CACCCAGTGC GACGCTGCCA CTGAAGCCCT CTACTTTGGC 
TCTGACTACT GCGGCTTCCT CAACAAGACA GACGGCCCTC TGTGGGAGTG TGGCACTGTC 
GTGGACCCCA CTGCTTTTGT GCACAGCTGC GTGTATGACC TGTGCAGTGT GAGGGACAAT 
GGCACGCTCC TCTGCCAAGC CATCCAGGCC TATGCTCTTG TGTGCCAAGC CCTTGGCATT 
CCAATTGGAG ACTGGCGAAC CCAGACTGGG TGTGTGTCCA CAGTGCAGTG CCCGAGCTTC 
AGCCACTACT CCGTGTGCAC AAGCAGCTGC CCCGACACAT GCTCCGACCT GACGGCCTCG 
CGGAACTGCG CCACGCCGTG CACAGAGGGC TGCGAGTGCA ACCAGGGCTT CGTCCTCAGC 
ACCAGCCAGT GCGTCCCTCT GCACAAGTGC GGCTGCGACT TCGACGGCCA CTACTACACC 
ATGGGGGAGT TCTTCTGGGC CACGGCCAAC TGCACTGTGC AATGCCTGTG CGAGGAGGGC 
GGGGACGTCT ACTGCTTCAA CAAGACCTGC GGCAGCGGGG AGGTGTGCGC CGTGGAGGAC 
GGCTACCAGG GCTGCTTCCC CAAGCGGGAG ACCGTGTGCC TGCTCAGCCA GAACCAGGTG 
CTGCACACCT TTGACGGCGC CTCCTACGCC TTCCCCTCCG AGTTCTCCTA CACCCTCCTG 
AAGACCTGCC CTGAGCGCCC AGAGTACTTG GAAATCGACA TCAACAAGAA GAAGCCCGAT 
GCAGGACCTG CTTGGCTGCG GGGACTTCGG ATCCTGGTGG CCGACCAGGA GGTCAAGATA 
GGAGGCATCG GGGCTTCGGA AGTCAAGTTG AATGGTCAGG AAGTGGAATT GCCTTTTTTC 
CATCCTTCGG GGAAGCTGGA AATTTATCGA AACAAAAACA GTACGACAGT GGAGTCCAAG 
GGCGTGGTGA CTGTCCAGTA CTCAGACATA GGTCTATTGT ACATCCGGCT GTCCACCACA 
TACTTCAATT GCACAGGGGG CTTGTGCGGC TTCTACAATG CCAACGCCAG TGACGAGTTC 
TGTCTCCCCA ACGGCAAGTG CACGGACAAC CTGGCAGTGT TCCTGGAAAG CTGGACAACT 
TTCGAGGAGA TCTGCAATGG AGAGTGTGGG GACCTGCTGA AGGCCTGCAA CAATGACTCG 
GAGCTGCTCA AGTTTTATCG AAGCCGCTCC AGGTGCGGCA TCATCAACGA CCCCTCCAAC 
AGCTCCTTCC TGGAGTGCCA TGGGGTGGTG AACGTCACTG CCTATTACCG CACCTGCCTT 
TTCCGCCTGT GCCAGAGTGG GGGCAATGAG TCAGAGCTCT GTGACTCTGT GGCCCGGTAT 
GCAAGCGCCT GCAAGAATGC GGACGTGGAG GTGGGGCCCT GGCGGACCTA TGACTTCTGC 
CCACTGGAGT GCCCAGAGAA CAGCCACTTT GAGGAGTGCA TCACATGTAC AGAGACCTGT 
GAGACCCTTA CCCTGGGCCC CATCTGCGTG GATAGCTGCT CTGAGGGATG TCAGTGTGAT 
GAGGGCTATG CTCTACTGGG CAGCCAGTGT GTCACGCGGA GTGAGTGTGG CTGCAACTTT 
GAGGGGCACC AACTTGCCAC CAATGAGACC TTCTGGGTGG ACCTGGACTG CCAGATCTTC 
TGCTATTGCA GTGGCACAGA CAACAGGGTC CACTGCGAGA CCATTCCCTG CAAGGATGAT 
GAGTACTGCA TGGAGGAAGG TGGCCTGTAC TACTGCCAAG CCCGCACCGA CGCCTCCTGC 
ATCGTCTCAG GCTACGGCCA CTACCTCACC TTTGATGGCT TCCCCTTTGA CTTCCAGACC 
AGCTGCCCAC TCATCCTGTG CACCACAGGA AGCAGGCCAA GCTCAGACTC TTTCCCCAAG 
TTTGTTGTCA CAGCCAAGAA TGAGGACCGG GACCCGTCAC TGGCCTTGTG GGTTAAGCAG 
GTGGACGTGA CCGTGTTTGG CTACAGCATC GTGATCCACC GAGCTTACAA GCACACTGTG 
CTGGTCAACA GTGAACGGCT CTATCTGCCC CTGAAGCTGG GGCAAGGGAA GATAAATATC 
TTTTCCTTTG GCTTCCACGT GGTGGTGGAA ACTGATTTTG GCCTGAAGGT TGTATATGAC 
TGGAAGACCT TCCTGTCCAT CACAGTCCCT CGGAGCATGC AGAACAGCAC CTATGGTCTG 
TGTGGCCGCT ACAACGGCAA CCCTGATGAT GACCTGGAGA TGCCCATGGG TCTGCTTGCA 
TCGAGTGTCA ATGAGTTTGG GCAGAGCTGG GTGAAGAGGG ACACCTTCTG CCAGGTGGGC 
TGTGGGGACC GCTGTCCGTC CTGTGCCAAG GTGGAAGGTT TCTCCAAAGT GCAGCAGCTG 
TGCAGCCTGA TCCCCAACCA GAACGCTGCC TTCTCCAAGT GTCACAGCAA AGTTAACCCC 
ACCTTCTTCT ATAAGAACTG CCTGTTTGAC TCTTGCATCG ATGGGGGCGC GGTGCAGACC 
GCCTGCAGCT GGCTGCAGAA CTACGCCAGC ACCTGCCAGA CTCAGGGGAT TACGGTGACT 
GGCTGGAGGA ATTACACGTC CTGCACTGTC ACCTGCCCTC CAAACAGCCA TTACGAGAGC 
TGCGTGAGTG TCTGCCAGCC CCGCTGCGCC GCCATCCGCC TGAAGAGTGA CTGCAGCCAC 
TACTGCGTGG AGGGCTGTCA CTGCGACGCT GGCTACGTCC TCAACGGCAA GAGCTGCATC 
CTGCCCCACA GCTGCGGCTG CTACTCCGAT GGCAAATATT ACGAGCCCAA GCAGCTATTT 
TGGAACAGCG ACTGCACGCG GCGCTGCCGC TGTTTCCGTC GCAACGTGAT TCAGTGCGAC 
CCGCGCCAAT GCAAGTCAGA CGAGGAGTGT GCGCTGCGCA ACGGGGTGCG CGGCTGCTTC 
AGCACCAAGA CCTCCTACTG CCTGGCGGCC GGCGGCGGCG TCTTCCGCAC CTTCGACGGC 
GCCTTCCTGC GCTTCCCAGC CAACTGCGCC TTCGTGCTGT CCACCATCTG CCAGAAACTG 
CCCGACATCT CCTTCCAGCT TATCATCAAC TTCGACAAGT GGTCGGCCCC CAACCTCACC 
ATCATTTCGC CCGTCTACTT CTACATTAAC GAAGAGCAGA TTCTCATCAA CGACCGGAAC 
ACGGTCAAGG TGAATGGCAC ACAAGTGAAT GTTCCATTTA TAACTGGTTT GGCAACCAAA 
ATCTACAGCA GTGAGGGGTT TCTGGTGATT GACACCAGCC CAGACATCCA GATATACTAC 
AATGGTTTCA ACGTCATTAA AATCAGCATC AGCGAGAGGC TGCAGAACAA AGTGTGCGGT 
CTCTGTGGCA ACTTCAACGG GGACCTAACA GATGATTATG TGACCTTGCG AGGGAAGCCG 
GTGGTAAGCA GCGTGGTGCT GGCCCAGAGC TGGAAAACCA ATGGCATGCA GAAGAGACCT 
CTTGCCCCCA GCTGCAACGA GCTGCAGTTC TCACAGTATG CAGCCATGTG TGACAATGTG 
CACATCCAGA AGATGCAGGG TGATGGCTAC TGCCTGAAGC TCACCGACAT GAAGGGCTTC 
TTCCAGCCCT GCTATGGGCT TCTCGATCCC CTCCCATTCT ACGAGTCCTG CTACCTGGAC 
GGCTGCTACA GCCACAAGAA GTTCCAGCTG TGCGGCTCCC TGGCCGCCTA CGGGGAGGCC 
TGCCGCTCCT TCGGGATCCT TAGCACCGAG TGGATTGAGA AGGAGAATTG CTCAGGAGTG 
GTTGAAGATC CCTGTGTGGG GGCGGACTGT CCCAACCGAA CTTGCGAGCT GGGCAATGGC 
AGGGAGCTGT GTGGCTGCAT CGAGCCACCC CCCTATGGAA ATAACTCACA TGACATTATC 
GATGCAGAGG TGACCTGCAA AGCAGCCCAA ATGGAAGTGT CCATATCTAA GTGCAAGCTC 
TTCCAGCTCG GTTTTGAGAG GGAGGGCGTG AGGATCAATG ACAGACAGTG CACCGGCATC 
GAGGGGGAAG ATTTTATCTC CTTTCAGATC AACAACACCA AAGGGAATTG TGGAAACATT 
GTGCAGTCCA ATGGCACGCA TATCATGTAT AAAAACACAC TCTGGATCGA AAGCGCCAAC 
AACACTGGCA ACATCATCAC CAGGGACCGC ACGATCAATG TGGAATTTTC ATGTGCTTAT 
GAGCTGGATA TCAAGATCTC CTTGGATTCT GTTGTGAAGC CTATGCTAAG TGTAATTAAC 
CTGACAGTTC CAACCCAAGA AGGCAGCTTC ATCACCAAGA TGGCTCTCTA CAAAAACGCC 
TCCTACAAAC ATCCTTACCG CCAGGGTGAA GTAGTGTTGA CGACTCGAGA TGTGCTGTAT 
GTAGGGGTTT TTGTGGTTGG AGCTGACGCC ACACATTTAA TCCTAACACT CAACAAATGC 
TATGCCACAC CCACCCGAGA TAGCAATGAT AAGCTCCGAT ATTTCATCAT TGAAGGAGGG 
TGTCAGAACC TCAAAGATAA CACCATTGGC ATCGAGGAGA ATGCAGTCTC CCTGACCTGT 
CGCTTTCACG TCACCGTCTT TAAATTCATA GGGGATTACG ACGAAGTTCA CCTTCACTGT 
GCAGTGTCAC TCTGCGACTC AGAAAAGTAC TCCTGTAAAA TCACTTGCCC ACACAATTCC 
AGGATTGCCA CAGATTACAC AAAAGAGCCC AAAGAACAGA TCATTTCAGT GGGACCTATT 
AGGAGAAAAA GGCTGGACTG GTGTGAGGAC AATGGAGGGT GTGAGCAGAT TTGCACGAGC 
CGGGTGGATG GGCCTCTCTG CAGCTGTGTA ACAGGAACCC TGCAGGAGGA CGGCAAGAGC 
TGCAGAGCCT CTAATTCTTC AATGGAACTT CAAGTCTGGA CGCTTCTTCT CATCATGATC 
CAGATTTCAT TATGGCATTT TGTCTATAAA TCAGGCACGA CCTCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Prevalence of TECTA mutation in patients with mid-frequency sensorineural hearing loss.
Orphanet journal of rare diseases12(1)157(2017 Sep)
Yamamoto N,Mutai H,Namba K,Morita N,Masuda S,Nishi Y,Nakano A,Masuda S,Fujioka M,Kaga K,Ogawa K,Matsunaga T

A novel TECTA mutation causes ARNSHL.
International journal of pediatric otorhinolaryngology9288-93(2017 Jan)
Asgharzade S,Tabatabaiefar MA,Modarressi MH,Ghahremani MH,Reiisi S,Tahmasebi P,Abdollahnejad F,Chaleshtori MH

A novel biallelic splice site mutation of TECTA causes moderate to severe hearing impairment in an Algerian family.
International journal of pediatric otorhinolaryngology8728-33(2016 Aug)
Behlouli A,Bonnet C,Abdi S,Hasbellaoui M,Boudjenah F,Hardelin JP,Louha M,Makrelouf M,Ammar-Khodja F,Zenati A,Petit C

Research progress in pathogenic genes of hereditary non-syndromic mid-frequency deafness.
Frontiers of medicine10(2)137-42(2016 Jun)
Xia W,Liu F,Ma D

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TECTA cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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