PRDX2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PRDX2
Entrez Gene ID	7001
Full Name	peroxiredoxin 2
Synonyms	HEL-S-2a,NKEF-B,NKEFB,PRP,PRX2,PRXII,PTX1,TDPX1,TPX1,TSA
General protein information	Preferred Names peroxiredoxin 2 Names peroxiredoxin-2 epididymis secretory sperm binding protein Li 2a natural killer cell-enhancing factor B thiol-specific antioxidant 1 thioredoxin peroxidase 1 thioredoxin-dependent peroxide reductase 1 torin
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.13
Summary	This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and play a role in cancer development or progression. Related pseudogenes have been identified on chromosomes 5, 6, 10 and 13. [provided by RefSeq, Mar 2013].
Disorder MIM:	600538

mRNA and Protein(s)

mRNA	Protein	Name
NM_005809.5	NP_005800.3	peroxiredoxin-2
NM_005809.6	NP_005800.3	peroxiredoxin-2

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Prdx2	NP_035693.3
Anopheles gambiae (African malaria mosquito)	TPX2	XP_308081.2
Arabidopsis thaliana (thale cress)	AT3G11630	NP_187769.1
Arabidopsis thaliana (thale cress)	2-Cys Prx B	NP_568166.1
Saccharomyces cerevisiae (baker's yeast)	TSA1	NP_013684.1
Pan troglodytes (chimpanzee)	PRDX2	XP_003953433.1
Bos taurus (cattle)	PRDX2	NP_777188.1
Schizosaccharomyces pombe (fission yeast)	tpx1	NP_588430.1
Homo sapiens (human)	PRDX2	NP_005800.3
Canis lupus familiaris (dog)	PRDX2	XP_003639771.1
Rattus norvegicus (Norway rat)	Prdx2	NP_058865.1
Danio rerio (zebrafish)	prdx2	NP_001002468.1
Drosophila melanogaster (fruit fly)	Jafrac1	NP_477510.1
Caenorhabditis elegans (roundworm)	prdx-2	NP_001122604.1
Oryza sativa (rice)	Os02g0537700	NP_001047050.1
Xenopus tropicalis (tropical clawed frog)	prdx2	NP_989001.1
	PRDX2	XP_001109216.1

Gene Ontology
Bibliography

Related articles in PubMed

Urate hydroperoxide oxidizes human peroxiredoxin 1 and peroxiredoxin 2.
Carvalho LAC, Truzzi DR, Fallani TS, Alves SV, Toledo JC Jr, Augusto O, Netto LES, Meotti FC
The Journal of biological chemistry292(21)8705-8715(2017 05)

Expression of the Antioxidative Enzyme Peroxiredoxin 2 in Multiple Sclerosis Lesions in Relation to Inflammation.
Voigt D, Scheidt U, Derfuss T, Br?ck W, Junker A
International journal of molecular sciences18(4)(2017 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Prx1 and Prx2 are likely targets of urate hydroperoxide in cells. Oxidation of Prxs by urate hydroperoxide might affect cell function and be partially responsible for the pro-oxidant and pro-inflammatory effects of uric acid.
Title: Urate hydroperoxide oxidizes human peroxiredoxin 1 and peroxiredoxin 2.

Data indicate that peroxiredoxin 2 (PRDX2) was upregulated in white matter multiple sclerosis (MS) lesions mainly in astrocytes, and its expression level was positively correlated with the degree of inflammation and oxidative stress, and suggest that PRDX2 expression contributes to the resistance of astrocytes against oxidative damage.
Title: Expression of the Antioxidative Enzyme Peroxiredoxin 2 in Multiple Sclerosis Lesions in Relation to Inflammation.

Activation of PRX1 and -2 indicate cold atmospheric plasma affects redox homeostasis in osteosarcoma cells
Title: Peroxiredoxin Expression of Human Osteosarcoma Cells Is Influenced by Cold Atmospheric Plasma Treatment.

ig-h3, Peroxiredoxin-2, and NRF2 have roles in cervical carcinogenesis
Title: Cervical Cancer Cell Line Secretome Highlights the Roles of Transforming Growth Factor-Beta-Induced Protein ig-h3, Peroxiredoxin-2, and NRF2 on Cervical Carcinogenesis.

Association and oligomerization of Prx II could take part in recovery and protection of the CK BB enzyme activity from inactivation during heat-induced stress.
Title: Prx II and CKBB proteins interaction under physiologic al and thermal stress conditions in A549 and HeLa cells.

The following PRDX2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PRDX2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21359	NM_005809.6 Latest version!	Homo sapiens peroxiredoxin 2 (PRDX2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu21359	NM_005809.5	Homo sapiens peroxiredoxin 2 (PRDX2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PRDX2 ( NM_005809.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_005800.3 Homo sapiens peroxiredoxin 2 (PRDX2), mRNA.

Price & Availability↑

CloneID	OHu21359
Clone ID Related Accession (Same CDS sequence)	NM_005809.5 , NM_005809.6
Accession Version	NM_005809.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 597bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-17
Organism	Homo sapiens(human)
Product	peroxiredoxin-2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP248561.1, BC000452.2 and BQ549456.1. This sequence is a reference standard in the RefSeqGene project. On Mar 13, 2013 this sequence version replaced NM_005809.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279840.6370.1, SRR1163655.302612.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2145893 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCTCCG GTAACGCGCG CATCGGAAAG CCAGCCCCTG ACTTCAAGGC CACAGCGGTG 
GTTGATGGCG CCTTCAAAGA GGTGAAGCTG TCGGACTACA AAGGGAAGTA CGTGGTCCTC 
TTTTTCTACC CTCTGGACTT CACTTTTGTG TGCCCCACCG AGATCATCGC GTTCAGCAAC 
CGTGCAGAGG ACTTCCGCAA GCTGGGCTGT GAAGTGCTGG GCGTCTCGGT GGACTCTCAG 
TTCACCCACC TGGCTTGGAT CAACACCCCC CGGAAAGAGG GAGGCTTGGG CCCCCTGAAC 
ATCCCCCTGC TTGCTGACGT GACCAGACGC TTGTCTGAGG ATTACGGCGT GCTGAAAACA 
GATGAGGGCA TTGCCTACAG GGGCCTCTTT ATCATCGATG GCAAGGGTGT CCTTCGCCAG 
ATCACTGTTA ATGATTTGCC TGTGGGACGC TCCGTGGATG AGGCTCTGCG GCTGGTCCAG 
GCCTTCCAGT ACACAGACGA GCATGGGGAA GTTTGTCCCG CTGGCTGGAA GCCTGGCAGT 
GACACGATTA AGCCCAACGT GGATGACAGC AAGGAATATT TCTCCAAACA CAATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005800.3
CDS	181..777
Translation	MASGNARIGKPAPDFKATAVVDGAFKEVKLSDYKGKYVVLFFYPLDFTFVCPTEIIAFSNRAEDFRKLGCEVLGVSVDSQFTHLAWINTPRKEGGLGPLNIPLLADVTRRLSEDYGVLKTDEGIAYRGLFIIDGKGVLRQITVNDLPVGRSVDEALRLVQAFQYTDEHGEVCPAGWKPGSDTIKPNVDDSKEYFSKHN

Target ORF information:

RefSeq Version	NM_005809.5
Organism	Homo sapiens(human)
Definition	Homo sapiens peroxiredoxin 2 (PRDX2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005809.5

ORF Insert Sequence:

ATGGCCTCCG GTAACGCGCG CATCGGAAAG CCAGCCCCTG ACTTCAAGGC CACAGCGGTG 
GTTGATGGCG CCTTCAAAGA GGTGAAGCTG TCGGACTACA AAGGGAAGTA CGTGGTCCTC 
TTTTTCTACC CTCTGGACTT CACTTTTGTG TGCCCCACCG AGATCATCGC GTTCAGCAAC 
CGTGCAGAGG ACTTCCGCAA GCTGGGCTGT GAAGTGCTGG GCGTCTCGGT GGACTCTCAG 
TTCACCCACC TGGCTTGGAT CAACACCCCC CGGAAAGAGG GAGGCTTGGG CCCCCTGAAC 
ATCCCCCTGC TTGCTGACGT GACCAGACGC TTGTCTGAGG ATTACGGCGT GCTGAAAACA 
GATGAGGGCA TTGCCTACAG GGGCCTCTTT ATCATCGATG GCAAGGGTGT CCTTCGCCAG 
ATCACTGTTA ATGATTTGCC TGTGGGACGC TCCGTGGATG AGGCTCTGCG GCTGGTCCAG 
GCCTTCCAGT ACACAGACGA GCATGGGGAA GTTTGTCCCG CTGGCTGGAA GCCTGGCAGT 
GACACGATTA AGCCCAACGT GGATGACAGC AAGGAATATT TCTCCAAACA CAATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PRDX2 ( NM_005809.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_005800.3 Homo sapiens peroxiredoxin 2 (PRDX2), mRNA.

Price & Availability↑

CloneID	OHu21359
Clone ID Related Accession (Same CDS sequence)	NM_005809.5 , NM_005809.6
Accession Version	NM_005809.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 597bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	peroxiredoxin-2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP248561.1 and BC000452.2. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_005809.5. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.565439.1, SRR1163655.50229.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2145893 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000301522.3/ ENSP00000301522.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCTCCG GTAACGCGCG CATCGGAAAG CCAGCCCCTG ACTTCAAGGC CACAGCGGTG 
GTTGATGGCG CCTTCAAAGA GGTGAAGCTG TCGGACTACA AAGGGAAGTA CGTGGTCCTC 
TTTTTCTACC CTCTGGACTT CACTTTTGTG TGCCCCACCG AGATCATCGC GTTCAGCAAC 
CGTGCAGAGG ACTTCCGCAA GCTGGGCTGT GAAGTGCTGG GCGTCTCGGT GGACTCTCAG 
TTCACCCACC TGGCTTGGAT CAACACCCCC CGGAAAGAGG GAGGCTTGGG CCCCCTGAAC 
ATCCCCCTGC TTGCTGACGT GACCAGACGC TTGTCTGAGG ATTACGGCGT GCTGAAAACA 
GATGAGGGCA TTGCCTACAG GGGCCTCTTT ATCATCGATG GCAAGGGTGT CCTTCGCCAG 
ATCACTGTTA ATGATTTGCC TGTGGGACGC TCCGTGGATG AGGCTCTGCG GCTGGTCCAG 
GCCTTCCAGT ACACAGACGA GCATGGGGAA GTTTGTCCCG CTGGCTGGAA GCCTGGCAGT 
GACACGATTA AGCCCAACGT GGATGACAGC AAGGAATATT TCTCCAAACA CAATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005800.3
CDS	71..667
Translation	MASGNARIGKPAPDFKATAVVDGAFKEVKLSDYKGKYVVLFFYPLDFTFVCPTEIIAFSNRAEDFRKLGCEVLGVSVDSQFTHLAWINTPRKEGGLGPLNIPLLADVTRRLSEDYGVLKTDEGIAYRGLFIIDGKGVLRQITVNDLPVGRSVDEALRLVQAFQYTDEHGEVCPAGWKPGSDTIKPNVDDSKEYFSKHN

Target ORF information:

RefSeq Version	NM_005809.6
Organism	Homo sapiens(human)
Definition	Homo sapiens peroxiredoxin 2 (PRDX2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005809.6

ORF Insert Sequence:

ATGGCCTCCG GTAACGCGCG CATCGGAAAG CCAGCCCCTG ACTTCAAGGC CACAGCGGTG 
GTTGATGGCG CCTTCAAAGA GGTGAAGCTG TCGGACTACA AAGGGAAGTA CGTGGTCCTC 
TTTTTCTACC CTCTGGACTT CACTTTTGTG TGCCCCACCG AGATCATCGC GTTCAGCAAC 
CGTGCAGAGG ACTTCCGCAA GCTGGGCTGT GAAGTGCTGG GCGTCTCGGT GGACTCTCAG 
TTCACCCACC TGGCTTGGAT CAACACCCCC CGGAAAGAGG GAGGCTTGGG CCCCCTGAAC 
ATCCCCCTGC TTGCTGACGT GACCAGACGC TTGTCTGAGG ATTACGGCGT GCTGAAAACA 
GATGAGGGCA TTGCCTACAG GGGCCTCTTT ATCATCGATG GCAAGGGTGT CCTTCGCCAG 
ATCACTGTTA ATGATTTGCC TGTGGGACGC TCCGTGGATG AGGCTCTGCG GCTGGTCCAG 
GCCTTCCAGT ACACAGACGA GCATGGGGAA GTTTGTCCCG CTGGCTGGAA GCCTGGCAGT 
GACACGATTA AGCCCAACGT GGATGACAGC AAGGAATATT TCTCCAAACA CAATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Urate hydroperoxide oxidizes human peroxiredoxin 1 and peroxiredoxin 2.
The Journal of biological chemistry292(21)8705-8715(2017 05)
Carvalho LAC,Truzzi DR,Fallani TS,Alves SV,Toledo JC Jr,Augusto O,Netto LES,Meotti FC

Expression of the Antioxidative Enzyme Peroxiredoxin 2 in Multiple Sclerosis Lesions in Relation to Inflammation.
International journal of molecular sciences18(4)(2017 Apr)
Voigt D,Scheidt U,Derfuss T,Br?ck W,Junker A

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PRDX2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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