TAF7 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TAF7
Entrez Gene ID	6879
Full Name	TATA-box binding protein associated factor 7
Synonyms	TAF2F,TAFII55
General protein information	Preferred Names TATA-box binding protein associated factor 7 Names transcription initiation factor TFIID subunit 7 RNA polymerase II TBP-associated factor subunit F TAF(II)55 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa TAFII-55 TATA box binding protein (TBP)-associated factor, RNA polymerase II, F, 55kD TBP-associated factor F transcription factor IID subunit TAFII55 transcription initiation factor TFIID, 55 kDa subunit
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q31.3
Summary	The intronless gene for this transcription coactivator is located between the protocadherin beta and gamma gene clusters on chromosome 5. The protein encoded by this gene is a component of the TFIID protein complex, a complex which binds to the TATA box in class II promoters and recruits RNA polymerase II and other factors. This particular subunit interacts with the largest TFIID subunit, as well as multiple transcription activators. The protein is required for transcription by promoters targeted by RNA polymerase II. [provided by RefSeq, Jul 2008].
Disorder MIM:	600573

mRNA and Protein(s)

mRNA	Protein	Name
NM_005642.2	NP_005633.2	transcription initiation factor TFIID subunit 7
NM_005642.3	NP_005633.2	transcription initiation factor TFIID subunit 7

Pathways from BioSystems

Homologies

	TAF7	XP_001092471.1
Canis lupus familiaris (dog)	TAF7	XP_544308.1
Gallus gallus (chicken)	TAF7	NP_001264815.1
Pan troglodytes (chimpanzee)	TAF7	XP_527047.1
Mus musculus (house mouse)	Taf7	NP_786964.1
Rattus norvegicus (Norway rat)	Taf7	NP_001100864.1
Bos taurus (cattle)	TAF7	NP_001039493.1
Homo sapiens (human)	TAF7	NP_005633.2
Danio rerio (zebrafish)	taf7	NP_775367.1
Xenopus tropicalis (tropical clawed frog)	taf7	NP_001006764.1

Gene Ontology
Bibliography

Related articles in PubMed

Solution Structure of the N-Terminal Domain of Mediator Subunit MED26 and Molecular Characterization of Its Interaction with EAF1 and TAF7.
Lens Z, Cantrelle FX, Peruzzini R, Hanoulle X, Dewitte F, Ferreira E, Baert JL, Mont? D, Aumercier M, Villeret V, Verger A, Landrieu I
Journal of molecular biology429(20)3043-3055(2017 Oct)

Structure of promoter-bound TFIID and model of human pre-initiation complex assembly.
Louder RK, He Y, L?pez-Blanco JR, Fang J, Chac?n P, Nogales E
Nature531(7596)604-9(2016 03)

MED26 regulates the transcription of snRNA genes through the recruitment of little elongation complex.
Takahashi H, Takigawa I, Watanabe M, Anwar D, Shibata M, Tomomori-Sato C, Sato S, Ranjan A, Seidel CW, Tsukiyama T, Mizushima W, Hayashi M, Ohkawa Y, Conaway JW, Conaway RC, Hatakeyama S
Nature communications65941(2015 Jan)

Crystal structure of a TAF1-TAF7 complex in human transcription factor IID reveals a promoter binding module.
Wang H, Curran EC, Hinds TR, Wang EH, Zheng N
Cell research24(12)1433-44(2014 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

EAF1 (239-268) and TAF7 (205-235) peptide interactions were both mapped to the same groove formed by H3 and H4 helices of MED26 N-terminal domain.
Title: Solution Structure of the N-Terminal Domain of Mediator Subunit MED26 and Molecular Characterization of Its Interaction with EAF1 and TAF7.

the MED26-NTD functions as a molecular switch in the exchange of TBP-associated factor 7 (TAF7) for LEC to facilitate the transition from initiation to elongation during transcription of a subset of snRNA genes
Title: MED26 regulates the transcription of snRNA genes through the recruitment of little elongation complex.

These results resolve the structural organization of the TAF1-TAF7 module in TFIID and unveil a critical promoter-binding function of TAF1 in transcription regulation.
Title: Crystal structure of a TAF1-TAF7 complex in human transcription factor IID reveals a promoter binding module.

the surface of the TAF1-TAF7 complex contains two prominent conserved surface pockets, one of which binds selectively to an inhibitory trimethylated histone H3
Title: Structural and functional insight into TAF1-TAF7, a subcomplex of transcription factor II D.

three CTD kinases, CDK7, CDK9, and BRD4, engage in cross-talk, modulating their subsequent C-terminal domain phosphorylation, and also phosphorylate TAF7
Title: Cross-talk among RNA polymerase II kinases modulates C-terminal domain phosphorylation.

The following TAF7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TAF7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29365	NM_005642.3 Latest version!	Homo sapiens TATA-box binding protein associated factor 7 (TAF7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu29365	NM_005642.2	Homo sapiens TATA-box binding protein associated factor 7 (TAF7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TAF7 ( NM_005642.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_005633.2 Homo sapiens TATA-box binding protein associated factor 7 (TAF7), mRNA.

Price & Availability↑

CloneID	OHu29365
Clone ID Related Accession (Same CDS sequence)	NM_005642.2 , NM_005642.3
Accession Version	NM_005642.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1050bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Homo sapiens(human)
Product	transcription initiation factor TFIID subunit 7
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF349038.1. On Jul 13, 2001 this sequence version replaced NM_005642.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC013397.2 [ECO:0000345] ##Evidence-Data-END## COMPLETENESS: full length.

ATGAGTAAAA GCAAAGATGA TGCTCCTCAC GAACTGGAGA GCCAGTTTAT CTTACGTCTG 
CCTCCAGAAT ATGCCTCTAC TGTGAGAAGG GCAGTACAGT CTGGTCATGT CAACCTCAAG 
GACAGACTGA CAATTGAGTT ACATCCTGAT GGGCGTCATG GAATCGTCAG AGTGGACCGT 
GTTCCATTGG CCTCAAAATT AGTAGACCTG CCCTGTGTTA TGGAAAGCTT GAAAACCATT 
GATAAAAAAA CTTTTTACAA GACAGCTGAT ATCTGTCAGA TGCTTGTATC CACAGTTGAT 
GGTGATCTCT ATCCTCCTGT GGAGGAGCCA GTTGCTAGCA CTGATCCTAA AGCAAGCAAG 
AAAAAGGATA AGGACAAAGA GAAAAAGTTT ATCTGGAACC ACGGAATTAC TCTGCCTCTA 
AAGAATGTCA GGAAGAGAAG GTTCCGGAAG ACAGCAAAGA AGAAATATAT TGAATCTCCA 
GATGTTGAAA AAGAAGTGAA ACGATTGCTG AGTACAGATG CTGAAGCTGT TAGTACTCGG 
TGGGAAATAA TTGCCGAAGA TGAAACAAAG GAGGCAGAAA ATCAAGGCCT GGATATCTCT 
TCTCCAGGAA TGTCTGGTCA CAGGCAGGGC CATGACTCAT TAGAACATGA TGAGCTTCGG 
GAGATATTCA ATGACCTCAG CAGCAGCAGT GAGGATGAAG ATGAGACCCA GCATCAAGAT 
GAAGAAGATA TAAACATCAT TGACACGGAG GAAGATCTGG AGAGACAGCT ACAGGACAAG 
CTAAATGAAT CAGATGAACA GCACCAGGAA AATGAAGGAA CCAATCAGCT GGTTATGGGA 
ATTCAGAAGC AGATTGACAA CATGAAAGGC AAGCTCCAAG AGACCCAGGA CAGGGCAAAA 
CGACAAGAGG ATCTCATCAT GAAAGTGGAA AATCTGGCTC TCAAGAACAG ATTTCAGGCT 
GTACTGGATG AGCTCAAACA AAAGGAAGAC CGAGAAAAGG AGCAACTCAG CTCTTTGCAA 
GAGGAGCTAG AATCACTCCT AGAGAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005633.2
CDS	741..1790
Translation	MSKSKDDAPHELESQFILRLPPEYASTVRRAVQSGHVNLKDRLTIELHPDGRHGIVRVDRVPLASKLVDLPCVMESLKTIDKKTFYKTADICQMLVSTVDGDLYPPVEEPVASTDPKASKKKDKDKEKKFIWNHGITLPLKNVRKRRFRKTAKKKYIESPDVEKEVKRLLSTDAEAVSTRWEIIAEDETKEAENQGLDISSPGMSGHRQGHDSLEHDELREIFNDLSSSSEDEDETQHQDEEDINIIDTEEDLERQLQDKLNESDEQHQENEGTNQLVMGIQKQIDNMKGKLQETQDRAKRQEDLIMKVENLALKNRFQAVLDELKQKEDREKEQLSSLQEELESLLEK

Target ORF information:

RefSeq Version	NM_005642.2
Organism	Homo sapiens(human)
Definition	Homo sapiens TATA-box binding protein associated factor 7 (TAF7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005642.2

ORF Insert Sequence:

ATGAGTAAAA GCAAAGATGA TGCTCCTCAC GAACTGGAGA GCCAGTTTAT CTTACGTCTG 
CCTCCAGAAT ATGCCTCTAC TGTGAGAAGG GCAGTACAGT CTGGTCATGT CAACCTCAAG 
GACAGACTGA CAATTGAGTT ACATCCTGAT GGGCGTCATG GAATCGTCAG AGTGGACCGT 
GTTCCATTGG CCTCAAAATT AGTAGACCTG CCCTGTGTTA TGGAAAGCTT GAAAACCATT 
GATAAAAAAA CTTTTTACAA GACAGCTGAT ATCTGTCAGA TGCTTGTATC CACAGTTGAT 
GGTGATCTCT ATCCTCCTGT GGAGGAGCCA GTTGCTAGCA CTGATCCTAA AGCAAGCAAG 
AAAAAGGATA AGGACAAAGA GAAAAAGTTT ATCTGGAACC ACGGAATTAC TCTGCCTCTA 
AAGAATGTCA GGAAGAGAAG GTTCCGGAAG ACAGCAAAGA AGAAATATAT TGAATCTCCA 
GATGTTGAAA AAGAAGTGAA ACGATTGCTG AGTACAGATG CTGAAGCTGT TAGTACTCGG 
TGGGAAATAA TTGCCGAAGA TGAAACAAAG GAGGCAGAAA ATCAAGGCCT GGATATCTCT 
TCTCCAGGAA TGTCTGGTCA CAGGCAGGGC CATGACTCAT TAGAACATGA TGAGCTTCGG 
GAGATATTCA ATGACCTCAG CAGCAGCAGT GAGGATGAAG ATGAGACCCA GCATCAAGAT 
GAAGAAGATA TAAACATCAT TGACACGGAG GAAGATCTGG AGAGACAGCT ACAGGACAAG 
CTAAATGAAT CAGATGAACA GCACCAGGAA AATGAAGGAA CCAATCAGCT GGTTATGGGA 
ATTCAGAAGC AGATTGACAA CATGAAAGGC AAGCTCCAAG AGACCCAGGA CAGGGCAAAA 
CGACAAGAGG ATCTCATCAT GAAAGTGGAA AATCTGGCTC TCAAGAACAG ATTTCAGGCT 
GTACTGGATG AGCTCAAACA AAAGGAAGAC CGAGAAAAGG AGCAACTCAG CTCTTTGCAA 
GAGGAGCTAG AATCACTCCT AGAGAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TAF7 ( NM_005642.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005633.2 Homo sapiens TATA-box binding protein associated factor 7 (TAF7), mRNA.

Price & Availability↑

CloneID	OHu29365
Clone ID Related Accession (Same CDS sequence)	NM_005642.2 , NM_005642.3
Accession Version	NM_005642.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1050bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Homo sapiens(human)
Product	transcription initiation factor TFIID subunit 7
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC005618.1. On May 17, 2019 this sequence version replaced NM_005642.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: SRR7346977.1113176.1, SRR7346977.852194.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000313368.8/ ENSP00000312709.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGTAAAA GCAAAGATGA TGCTCCTCAC GAACTGGAGA GCCAGTTTAT CTTACGTCTG 
CCTCCAGAAT ATGCCTCTAC TGTGAGAAGG GCAGTACAGT CTGGTCATGT CAACCTCAAG 
GACAGACTGA CAATTGAGTT ACATCCTGAT GGGCGTCATG GAATCGTCAG AGTGGACCGT 
GTTCCATTGG CCTCAAAATT AGTAGACCTG CCCTGTGTTA TGGAAAGCTT GAAAACCATT 
GATAAAAAAA CTTTTTACAA GACAGCTGAT ATCTGTCAGA TGCTTGTATC CACAGTTGAT 
GGTGATCTCT ATCCTCCTGT GGAGGAGCCA GTTGCTAGCA CTGATCCTAA AGCAAGCAAG 
AAAAAGGATA AGGACAAAGA GAAAAAGTTT ATCTGGAACC ACGGAATTAC TCTGCCTCTA 
AAGAATGTCA GGAAGAGAAG GTTCCGGAAG ACAGCAAAGA AGAAATATAT TGAATCTCCA 
GATGTTGAAA AAGAAGTGAA ACGATTGCTG AGTACAGATG CTGAAGCTGT TAGTACTCGG 
TGGGAAATAA TTGCCGAAGA TGAAACAAAG GAGGCAGAAA ATCAAGGCCT GGATATCTCT 
TCTCCAGGAA TGTCTGGTCA CAGGCAGGGC CATGACTCAT TAGAACATGA TGAGCTTCGG 
GAGATATTCA ATGACCTCAG CAGCAGCAGT GAGGATGAAG ATGAGACCCA GCATCAAGAT 
GAAGAAGATA TAAACATCAT TGACACGGAG GAAGATCTGG AGAGACAGCT ACAGGACAAG 
CTAAATGAAT CAGATGAACA GCACCAGGAA AATGAAGGAA CCAATCAGCT GGTTATGGGA 
ATTCAGAAGC AGATTGACAA CATGAAAGGC AAGCTCCAAG AGACCCAGGA CAGGGCAAAA 
CGACAAGAGG ATCTCATCAT GAAAGTGGAA AATCTGGCTC TCAAGAACAG ATTTCAGGCT 
GTACTGGATG AGCTCAAACA AAAGGAAGAC CGAGAAAAGG AGCAACTCAG CTCTTTGCAA 
GAGGAGCTAG AATCACTCCT AGAGAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005633.2
CDS	741..1790
Translation	MSKSKDDAPHELESQFILRLPPEYASTVRRAVQSGHVNLKDRLTIELHPDGRHGIVRVDRVPLASKLVDLPCVMESLKTIDKKTFYKTADICQMLVSTVDGDLYPPVEEPVASTDPKASKKKDKDKEKKFIWNHGITLPLKNVRKRRFRKTAKKKYIESPDVEKEVKRLLSTDAEAVSTRWEIIAEDETKEAENQGLDISSPGMSGHRQGHDSLEHDELREIFNDLSSSSEDEDETQHQDEEDINIIDTEEDLERQLQDKLNESDEQHQENEGTNQLVMGIQKQIDNMKGKLQETQDRAKRQEDLIMKVENLALKNRFQAVLDELKQKEDREKEQLSSLQEELESLLEK

Target ORF information:

RefSeq Version	NM_005642.3
Organism	Homo sapiens(human)
Definition	Homo sapiens TATA-box binding protein associated factor 7 (TAF7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005642.3

ORF Insert Sequence:

ATGAGTAAAA GCAAAGATGA TGCTCCTCAC GAACTGGAGA GCCAGTTTAT CTTACGTCTG 
CCTCCAGAAT ATGCCTCTAC TGTGAGAAGG GCAGTACAGT CTGGTCATGT CAACCTCAAG 
GACAGACTGA CAATTGAGTT ACATCCTGAT GGGCGTCATG GAATCGTCAG AGTGGACCGT 
GTTCCATTGG CCTCAAAATT AGTAGACCTG CCCTGTGTTA TGGAAAGCTT GAAAACCATT 
GATAAAAAAA CTTTTTACAA GACAGCTGAT ATCTGTCAGA TGCTTGTATC CACAGTTGAT 
GGTGATCTCT ATCCTCCTGT GGAGGAGCCA GTTGCTAGCA CTGATCCTAA AGCAAGCAAG 
AAAAAGGATA AGGACAAAGA GAAAAAGTTT ATCTGGAACC ACGGAATTAC TCTGCCTCTA 
AAGAATGTCA GGAAGAGAAG GTTCCGGAAG ACAGCAAAGA AGAAATATAT TGAATCTCCA 
GATGTTGAAA AAGAAGTGAA ACGATTGCTG AGTACAGATG CTGAAGCTGT TAGTACTCGG 
TGGGAAATAA TTGCCGAAGA TGAAACAAAG GAGGCAGAAA ATCAAGGCCT GGATATCTCT 
TCTCCAGGAA TGTCTGGTCA CAGGCAGGGC CATGACTCAT TAGAACATGA TGAGCTTCGG 
GAGATATTCA ATGACCTCAG CAGCAGCAGT GAGGATGAAG ATGAGACCCA GCATCAAGAT 
GAAGAAGATA TAAACATCAT TGACACGGAG GAAGATCTGG AGAGACAGCT ACAGGACAAG 
CTAAATGAAT CAGATGAACA GCACCAGGAA AATGAAGGAA CCAATCAGCT GGTTATGGGA 
ATTCAGAAGC AGATTGACAA CATGAAAGGC AAGCTCCAAG AGACCCAGGA CAGGGCAAAA 
CGACAAGAGG ATCTCATCAT GAAAGTGGAA AATCTGGCTC TCAAGAACAG ATTTCAGGCT 
GTACTGGATG AGCTCAAACA AAAGGAAGAC CGAGAAAAGG AGCAACTCAG CTCTTTGCAA 
GAGGAGCTAG AATCACTCCT AGAGAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Solution Structure of the N-Terminal Domain of Mediator Subunit MED26 and Molecular Characterization of Its Interaction with EAF1 and TAF7.
Journal of molecular biology429(20)3043-3055(2017 Oct)
Lens Z,Cantrelle FX,Peruzzini R,Hanoulle X,Dewitte F,Ferreira E,Baert JL,Mont? D,Aumercier M,Villeret V,Verger A,Landrieu I

Structure of promoter-bound TFIID and model of human pre-initiation complex assembly.
Nature531(7596)604-9(2016 03)
Louder RK,He Y,L?pez-Blanco JR,Fang J,Chac?n P,Nogales E

MED26 regulates the transcription of snRNA genes through the recruitment of little elongation complex.
Nature communications65941(2015 Jan)
Takahashi H,Takigawa I,Watanabe M,Anwar D,Shibata M,Tomomori-Sato C,Sato S,Ranjan A,Seidel CW,Tsukiyama T,Mizushima W,Hayashi M,Ohkawa Y,Conaway JW,Conaway RC,Hatakeyama S

Crystal structure of a TAF1-TAF7 complex in human transcription factor IID reveals a promoter binding module.
Cell research24(12)1433-44(2014 Dec)
Wang H,Curran EC,Hinds TR,Wang EH,Zheng N

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TAF7 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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