SYN1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SYN1
Entrez Gene ID	6853
Full Name	synapsin I
Synonyms	SYN1a,SYN1b,SYNI
General protein information	Preferred Names synapsin I Names synapsin-1 brain protein 4.1 synapsin Ib
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xp11.3-p11.23
Summary	This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Disorder MIM:	313440
Disorder Html:	Epilepsy, X-linked, with variable learning disabilities and behavior disorders, 300491 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_006950.3	NP_008881.2	synapsin-1 isoform Ia
NM_133499.2	NP_598006.1	synapsin-1 isoform Ib

Pathways from BioSystems

Homologies

Bos taurus (cattle)	SYN1	NP_776616.1
Canis lupus familiaris (dog)	SYN1	XP_003435552.1
Rattus norvegicus (Norway rat)	Syn1	NP_062006.1
Danio rerio (zebrafish)	syn1	NP_001119909.1
Xenopus tropicalis (tropical clawed frog)	LOC100158514	NP_001121423.1
Homo sapiens (human)	SYN1	NP_008881.2
Mus musculus (house mouse)	Syn1	NP_038708.3

Gene Ontology
Bibliography

Related articles in PubMed

A novel SYN1 missense mutation in non-syndromic X-linked intellectual disability affects synaptic vesicle life cycle, clustering and mobility.
Guarnieri FC, Pozzi D, Raimondi A, Fesce R, Valente MM, Delvecchio VS, Van Esch H, Matteoli M, Benfenati F, D'Adamo P, Valtorta F
Human molecular genetics26(23)4699-4714(2017 Dec)

DNA hypomethylation of Synapsin II CpG islands associates with increased gene expression in bipolar disorder and major depression.
Cruceanu C, Kutsarova E, Chen ES, Checknita DR, Nagy C, Lopez JP, Alda M, Rouleau GA, Turecki G
BMC psychiatry16(1)286(2016 08)

[Development of the Human Olfactory Bulbs in the Prenatal Ontogenesis: an Immunochistochemical Study with Markers of Presynaptic Terminals (anti-SNAP-25, -Synapsin-I, -Synaptophysin)].
Kharlamova AS, Barabanov VM, Saveliev SV
Ontogenez46(3)174-85(2015 May-Jun)

Increased synapsin I expression in cerebral malaria.
Thonsranoi K, Glaharn S, Punsawad C, Chaisri U, Krudsood S, Viriyavejakul P
International journal of clinical and experimental pathology8(11)13996-4004(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These findings contribute to previous work showing dysregulation of Synapsins, particularly SYN2, in mood disorders and improve our understanding of the regulatory mechanisms that precipitate these changes likely leading to the BD or MDD phenotype.
Title: DNA hypomethylation of Synapsin II CpG islands associates with increased gene expression in bipolar disorder and major depression.

Patterns of the immunoreactivity with antibodies to SNAP-25, synapsin-I and synaptophysin are completely appropriate to those of adult's OB on the 38-40 weeks of the prenatal development.
Title: [Development of the Human Olfactory Bulbs in the Prenatal Ontogenesis: an Immunochistochemical Study with Markers of Presynaptic Terminals (anti-SNAP-25, -Synapsin-I, -Synaptophysin)].

Cerebral malaria causes pre-synaptic excitation and eventually activation of synapsin I, leading to increased neurotransmitter release.
Title: Increased synapsin I expression in cerebral malaria.

The implementation of the AlphaScreen pSYN1 assay and future development of additional primary neuronal HTS assays provides an attractive approach for discovery of novel classes of therapeutic candidates for a variety of CNS disorders.
Title: Development of a high-throughput AlphaScreen assay for modulators of synapsin I phosphorylation in primary neurons.

these findings suggest PRICKLE1 mutations contribute to ASD by disrupting the interaction with SYN1 and regulation of synaptic vesicles.
Title: PRICKLE1 interaction with SYNAPSIN I reveals a role in autism spectrum disorders.

The following SYN1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SYN1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu06002	NM_133499.2 Latest version!	Homo sapiens synapsin I (SYN1), transcript variant Ib, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$391.30 $559.00
OHu18256	NM_006950.3 Latest version!	Homo sapiens synapsin I (SYN1), transcript variant Ia, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$496.30 $709.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SYN1 ( NM_133499.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_598006.1 Homo sapiens synapsin I (SYN1), transcript variant Ib, mRNA.

Price & Availability↑

CloneID	OHu06002
Clone ID Related Accession (Same CDS sequence)	NM_133499.2
Accession Version	NM_133499.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2010bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	synapsin-1 isoform Ib
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AI929645.1, BC048799.1 and BC036711.2. On Apr 13, 2006 this sequence version replaced NM_133499.1. Transcript Variant: This variant (Ib) utilizes an alternative splice acceptor site in terminal exon compared to variant Ia, resulting in the lack of an internal segment and a frameshift. This variant encodes isoform Ib, which contains a shorter carboxyl terminus and a distinct domain F, as compared to isoform Ia. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC048799.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGAACTACC TGCGGCGCCG CCTGTCGGAC AGCAACTTTA TGGCCAATCT GCCAAATGGG 
TACATGACAG ACCTGCAGCG TCCGCAGCCG CCCCCACCGC CGCCCGGTGC CCACAGCCCC 
GGAGCCACGC CCGGTCCCGG GACCGCCACT GCCGAGAGGT CCTCCGGGGT CGCCCCAGCG 
GCCTCTCCGG CCGCCCCTAG CCCCGGGTCC TCGGGGGGCG GTGGCTTCTT CTCGTCGCTG 
TCCAACGCGG TCAAGCAGAC CACGGCGGCG GCAGCTGCCA CCTTCAGCGA GCAGGTGGGC 
GGCGGCTCTG GGGGCGCAGG CCGCGGGGGA GCCGCCTCCA GGGTGCTGCT GGTCATCGAC 
GAGCCGCACA CCGACTGGGC AAAATACTTC AAAGGGAAAA AGATCCATGG AGAAATTGAC 
ATTAAAGTAG AACAGGCCGA ATTCTCTGAT CTCAACCTTG TGGCCCATGC CAATGGTGGA 
TTCTCTGTGG ATATGGAAGT TCTTCGGAAT GGGGTGAAGG TCGTGCGGTC TCTGAAGCCG 
GATTTTGTGC TGATCCGCCA GCACGCCTTC AGCATGGCAC GCAACGGAGA CTACCGCAGT 
TTGGTCATTG GGCTGCAGTA TGCTGGAATC CCCAGTGTTA ACTCCTTGCA TTCTGTCTAC 
AACTTCTGTG ACAAGCCCTG GGTGTTTGCC CAGATGGTTC GACTGCATAA GAAACTGGGG 
ACAGAAGAAT TCCCTCTAAT TGATCAGACC TTCTACCCCA ATCACAAAGA AATGCTCAGC 
AGTACAACGT ACCCCGTGGT TGTGAAGATG GGGCACGCAC ACTCTGGGAT GGGCAAGGTC 
AAGGTTGACA ACCAGCATGA CTTCCAGGAC ATCGCAAGTG TCGTGGCACT GACCAAGACG 
TATGCCACTG CCGAGCCCTT CATCGATGCC AAATATGACG TGCGTGTCCA GAAGATTGGG 
CAGAACTACA AGGCCTACAT GAGGACGTCA GTGTCAGGGA ACTGGAAGAC CAATACTGGC 
TCTGCGATGC TGGAGCAAAT TGCCATGTCT GACAGATACA AGCTGTGGGT GGACACGTGC 
TCAGAGATTT TTGGGGGACT GGACATCTGC GCAGTGGAAG CGCTACATGG CAAGGACGGA 
AGGGATCACA TCATTGAGGT GGTGGGTTCC TCCATGCCGC TCATTGGTGA CCACCAGGAT 
GAAGACAAAC AGCTCATCGT AGAGCTCGTG GTCAACAAGA TGGCTCAGGC CCTGCCCCGG 
CAGCGACAGC GGGATGCCTC CCCTGGCAGG GGCTCCCATG GCCAGACTCC GTCCCCAGGG 
GCCCTGCCCT TGGGCCGCCA GACCTCCCAG CAGCCCGCAG GGCCCCCGGC TCAGCAGCGA 
CCCCCACCAC AGGGCGGCCC TCCACAGCCG GGTCCAGGCC CCCAGCGCCA GGGACCCCCA 
TTGCAGCAGC GCCCGCCCCC GCAGGGCCAG CAGCACCTTT CAGGCCTTGG ACCCCCAGCT 
GGCAGCCCCC TGCCCCAGCG CCTTCCAAGT CCCACCTCAG CGCCCCAGCA GCCCGCGTCC 
CAGGCCGCGC CGCCGACCCA GGGTCAAGGC CGCCAATCCC GGCCAGTGGC GGGAGGCCCC 
GGGGCGCCTC CAGCAGCCCG CCCGCCCGCC TCTCCGTCTC CCCAGCGCCA GGCGGGCCCC 
CCACAGGCTA CCCGTCAGAC ATCCGTCTCT GGCCCGGCTC CGCCAAAGGC CTCTGGGGCC 
CCACCGGGCG GGCAGCAGCG CCAGGGCCCG CCCCAGAAAC CCCCAGGCCC AGCCGGCCCC 
ACACGCCAGG CCAGCCAGGC GGGTCCCGTG CCCCGCACTG GGCCACCCAC CACGCAGCAG 
CCTCGGCCCA GCGGCCCGGG CCCCGCTGGA CGTCCCAAAC CACAGCTGGC CCAGAAACCC 
AGCCAGGACG TGCCGCCACC CGCCACCGCC GCTGCAGGGG GACCTCCGCA CCCCCAGCTC 
AAAGCCAGCC CCGCCCAGGC CCAGCCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_598006.1
CDS	130..2139
Translation	MNYLRRRLSDSNFMANLPNGYMTDLQRPQPPPPPPGAHSPGATPGPGTATAERSSGVAPAASPAAPSPGSSGGGGFFSSLSNAVKQTTAAAAATFSEQVGGGSGGAGRGGAASRVLLVIDEPHTDWAKYFKGKKIHGEIDIKVEQAEFSDLNLVAHANGGFSVDMEVLRNGVKVVRSLKPDFVLIRQHAFSMARNGDYRSLVIGLQYAGIPSVNSLHSVYNFCDKPWVFAQMVRLHKKLGTEEFPLIDQTFYPNHKEMLSSTTYPVVVKMGHAHSGMGKVKVDNQHDFQDIASVVALTKTYATAEPFIDAKYDVRVQKIGQNYKAYMRTSVSGNWKTNTGSAMLEQIAMSDRYKLWVDTCSEIFGGLDICAVEALHGKDGRDHIIEVVGSSMPLIGDHQDEDKQLIVELVVNKMAQALPRQRQRDASPGRGSHGQTPSPGALPLGRQTSQQPAGPPAQQRPPPQGGPPQPGPGPQRQGPPLQQRPPPQGQQHLSGLGPPAGSPLPQRLPSPTSAPQQPASQAAPPTQGQGRQSRPVAGGPGAPPAARPPASPSPQRQAGPPQATRQTSVSGPAPPKASGAPPGGQQRQGPPQKPPGPAGPTRQASQAGPVPRTGPPTTQQPRPSGPGPAGRPKPQLAQKPSQDVPPPATAAAGGPPHPQLKASPAQAQP

Target ORF information:

RefSeq Version	NM_133499.2
Organism	Homo sapiens(human)
Definition	Homo sapiens synapsin I (SYN1), transcript variant Ib, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133499.2

ORF Insert Sequence:

ATGAACTACC TGCGGCGCCG CCTGTCGGAC AGCAACTTTA TGGCCAATCT GCCAAATGGG 
TACATGACAG ACCTGCAGCG TCCGCAGCCG CCCCCACCGC CGCCCGGTGC CCACAGCCCC 
GGAGCCACGC CCGGTCCCGG GACCGCCACT GCCGAGAGGT CCTCCGGGGT CGCCCCAGCG 
GCCTCTCCGG CCGCCCCTAG CCCCGGGTCC TCGGGGGGCG GTGGCTTCTT CTCGTCGCTG 
TCCAACGCGG TCAAGCAGAC CACGGCGGCG GCAGCTGCCA CCTTCAGCGA GCAGGTGGGC 
GGCGGCTCTG GGGGCGCAGG CCGCGGGGGA GCCGCCTCCA GGGTGCTGCT GGTCATCGAC 
GAGCCGCACA CCGACTGGGC AAAATACTTC AAAGGGAAAA AGATCCATGG AGAAATTGAC 
ATTAAAGTAG AACAGGCCGA ATTCTCTGAT CTCAACCTTG TGGCCCATGC CAATGGTGGA 
TTCTCTGTGG ATATGGAAGT TCTTCGGAAT GGGGTGAAGG TCGTGCGGTC TCTGAAGCCG 
GATTTTGTGC TGATCCGCCA GCACGCCTTC AGCATGGCAC GCAACGGAGA CTACCGCAGT 
TTGGTCATTG GGCTGCAGTA TGCTGGAATC CCCAGTGTTA ACTCCTTGCA TTCTGTCTAC 
AACTTCTGTG ACAAGCCCTG GGTGTTTGCC CAGATGGTTC GACTGCATAA GAAACTGGGG 
ACAGAAGAAT TCCCTCTAAT TGATCAGACC TTCTACCCCA ATCACAAAGA AATGCTCAGC 
AGTACAACGT ACCCCGTGGT TGTGAAGATG GGGCACGCAC ACTCTGGGAT GGGCAAGGTC 
AAGGTTGACA ACCAGCATGA CTTCCAGGAC ATCGCAAGTG TCGTGGCACT GACCAAGACG 
TATGCCACTG CCGAGCCCTT CATCGATGCC AAATATGACG TGCGTGTCCA GAAGATTGGG 
CAGAACTACA AGGCCTACAT GAGGACGTCA GTGTCAGGGA ACTGGAAGAC CAATACTGGC 
TCTGCGATGC TGGAGCAAAT TGCCATGTCT GACAGATACA AGCTGTGGGT GGACACGTGC 
TCAGAGATTT TTGGGGGACT GGACATCTGC GCAGTGGAAG CGCTACATGG CAAGGACGGA 
AGGGATCACA TCATTGAGGT GGTGGGTTCC TCCATGCCGC TCATTGGTGA CCACCAGGAT 
GAAGACAAAC AGCTCATCGT AGAGCTCGTG GTCAACAAGA TGGCTCAGGC CCTGCCCCGG 
CAGCGACAGC GGGATGCCTC CCCTGGCAGG GGCTCCCATG GCCAGACTCC GTCCCCAGGG 
GCCCTGCCCT TGGGCCGCCA GACCTCCCAG CAGCCCGCAG GGCCCCCGGC TCAGCAGCGA 
CCCCCACCAC AGGGCGGCCC TCCACAGCCG GGTCCAGGCC CCCAGCGCCA GGGACCCCCA 
TTGCAGCAGC GCCCGCCCCC GCAGGGCCAG CAGCACCTTT CAGGCCTTGG ACCCCCAGCT 
GGCAGCCCCC TGCCCCAGCG CCTTCCAAGT CCCACCTCAG CGCCCCAGCA GCCCGCGTCC 
CAGGCCGCGC CGCCGACCCA GGGTCAAGGC CGCCAATCCC GGCCAGTGGC GGGAGGCCCC 
GGGGCGCCTC CAGCAGCCCG CCCGCCCGCC TCTCCGTCTC CCCAGCGCCA GGCGGGCCCC 
CCACAGGCTA CCCGTCAGAC ATCCGTCTCT GGCCCGGCTC CGCCAAAGGC CTCTGGGGCC 
CCACCGGGCG GGCAGCAGCG CCAGGGCCCG CCCCAGAAAC CCCCAGGCCC AGCCGGCCCC 
ACACGCCAGG CCAGCCAGGC GGGTCCCGTG CCCCGCACTG GGCCACCCAC CACGCAGCAG 
CCTCGGCCCA GCGGCCCGGG CCCCGCTGGA CGTCCCAAAC CACAGCTGGC CCAGAAACCC 
AGCCAGGACG TGCCGCCACC CGCCACCGCC GCTGCAGGGG GACCTCCGCA CCCCCAGCTC 
AAAGCCAGCC CCGCCCAGGC CCAGCCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SYN1 ( NM_006950.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_008881.2 Homo sapiens synapsin I (SYN1), transcript variant Ia, mRNA.

Price & Availability↑

CloneID	OHu18256
Clone ID Related Accession (Same CDS sequence)	NM_006950.3
Accession Version	NM_006950.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2118bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	synapsin-1 isoform Ia
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AI929645.1, BC048799.1, BC036711.2 and Z84466.2. This sequence is a reference standard in the RefSeqGene project. On Apr 13, 2006 this sequence version replaced NM_006950.2. Transcript Variant: This variant (Ia) represents the longer transcript, and encodes the longer isoform (Ia). This isoform (Ia) contains a distinct domain E, as compared to isoform Ib. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000295987.13/ ENSP00000295987.7 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAACTACC TGCGGCGCCG CCTGTCGGAC AGCAACTTTA TGGCCAATCT GCCAAATGGG 
TACATGACAG ACCTGCAGCG TCCGCAGCCG CCCCCACCGC CGCCCGGTGC CCACAGCCCC 
GGAGCCACGC CCGGTCCCGG GACCGCCACT GCCGAGAGGT CCTCCGGGGT CGCCCCAGCG 
GCCTCTCCGG CCGCCCCTAG CCCCGGGTCC TCGGGGGGCG GTGGCTTCTT CTCGTCGCTG 
TCCAACGCGG TCAAGCAGAC CACGGCGGCG GCAGCTGCCA CCTTCAGCGA GCAGGTGGGC 
GGCGGCTCTG GGGGCGCAGG CCGCGGGGGA GCCGCCTCCA GGGTGCTGCT GGTCATCGAC 
GAGCCGCACA CCGACTGGGC AAAATACTTC AAAGGGAAAA AGATCCATGG AGAAATTGAC 
ATTAAAGTAG AACAGGCCGA ATTCTCTGAT CTCAACCTTG TGGCCCATGC CAATGGTGGA 
TTCTCTGTGG ATATGGAAGT TCTTCGGAAT GGGGTGAAGG TCGTGCGGTC TCTGAAGCCG 
GATTTTGTGC TGATCCGCCA GCACGCCTTC AGCATGGCAC GCAACGGAGA CTACCGCAGT 
TTGGTCATTG GGCTGCAGTA TGCTGGAATC CCCAGTGTTA ACTCCTTGCA TTCTGTCTAC 
AACTTCTGTG ACAAGCCCTG GGTGTTTGCC CAGATGGTTC GACTGCATAA GAAACTGGGG 
ACAGAAGAAT TCCCTCTAAT TGATCAGACC TTCTACCCCA ATCACAAAGA AATGCTCAGC 
AGTACAACGT ACCCCGTGGT TGTGAAGATG GGGCACGCAC ACTCTGGGAT GGGCAAGGTC 
AAGGTTGACA ACCAGCATGA CTTCCAGGAC ATCGCAAGTG TCGTGGCACT GACCAAGACG 
TATGCCACTG CCGAGCCCTT CATCGATGCC AAATATGACG TGCGTGTCCA GAAGATTGGG 
CAGAACTACA AGGCCTACAT GAGGACGTCA GTGTCAGGGA ACTGGAAGAC CAATACTGGC 
TCTGCGATGC TGGAGCAAAT TGCCATGTCT GACAGATACA AGCTGTGGGT GGACACGTGC 
TCAGAGATTT TTGGGGGACT GGACATCTGC GCAGTGGAAG CGCTACATGG CAAGGACGGA 
AGGGATCACA TCATTGAGGT GGTGGGTTCC TCCATGCCGC TCATTGGTGA CCACCAGGAT 
GAAGACAAAC AGCTCATCGT AGAGCTCGTG GTCAACAAGA TGGCTCAGGC CCTGCCCCGG 
CAGCGACAGC GGGATGCCTC CCCTGGCAGG GGCTCCCATG GCCAGACTCC GTCCCCAGGG 
GCCCTGCCCT TGGGCCGCCA GACCTCCCAG CAGCCCGCAG GGCCCCCGGC TCAGCAGCGA 
CCCCCACCAC AGGGCGGCCC TCCACAGCCG GGTCCAGGCC CCCAGCGCCA GGGACCCCCA 
TTGCAGCAGC GCCCGCCCCC GCAGGGCCAG CAGCACCTTT CAGGCCTTGG ACCCCCAGCT 
GGCAGCCCCC TGCCCCAGCG CCTTCCAAGT CCCACCTCAG CGCCCCAGCA GCCCGCGTCC 
CAGGCCGCGC CGCCGACCCA GGGTCAAGGC CGCCAATCCC GGCCAGTGGC GGGAGGCCCC 
GGGGCGCCTC CAGCAGCCCG CCCGCCCGCC TCTCCGTCTC CCCAGCGCCA GGCGGGCCCC 
CCACAGGCTA CCCGTCAGAC ATCCGTCTCT GGCCCGGCTC CGCCAAAGGC CTCTGGGGCC 
CCACCGGGCG GGCAGCAGCG CCAGGGCCCG CCCCAGAAAC CCCCAGGCCC AGCCGGCCCC 
ACACGCCAGG CCAGCCAGGC GGGTCCCGTG CCCCGCACTG GGCCACCCAC CACGCAGCAG 
CCTCGGCCCA GCGGCCCGGG CCCCGCTGGA CGTCCCAAAC CACAGCTGGC CCAGAAACCC 
AGCCAGGACG TGCCGCCACC CGCCACCGCC GCTGCAGGGG GACCTCCGCA CCCCCAGCTC 
AACAAATCCC AGTCTCTGAC CAATGCCTTC AACCTTCCAG AGCCAGCCCC GCCCAGGCCC 
AGCCTTAGCC AGGACGAGGT GAAAGCTGAG ACCATCCGCA GCCTGAGGAA GTCTTTCGCC 
AGCCTCTTCT CCGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_008881.2
CDS	130..2247
Translation	MNYLRRRLSDSNFMANLPNGYMTDLQRPQPPPPPPGAHSPGATPGPGTATAERSSGVAPAASPAAPSPGSSGGGGFFSSLSNAVKQTTAAAAATFSEQVGGGSGGAGRGGAASRVLLVIDEPHTDWAKYFKGKKIHGEIDIKVEQAEFSDLNLVAHANGGFSVDMEVLRNGVKVVRSLKPDFVLIRQHAFSMARNGDYRSLVIGLQYAGIPSVNSLHSVYNFCDKPWVFAQMVRLHKKLGTEEFPLIDQTFYPNHKEMLSSTTYPVVVKMGHAHSGMGKVKVDNQHDFQDIASVVALTKTYATAEPFIDAKYDVRVQKIGQNYKAYMRTSVSGNWKTNTGSAMLEQIAMSDRYKLWVDTCSEIFGGLDICAVEALHGKDGRDHIIEVVGSSMPLIGDHQDEDKQLIVELVVNKMAQALPRQRQRDASPGRGSHGQTPSPGALPLGRQTSQQPAGPPAQQRPPPQGGPPQPGPGPQRQGPPLQQRPPPQGQQHLSGLGPPAGSPLPQRLPSPTSAPQQPASQAAPPTQGQGRQSRPVAGGPGAPPAARPPASPSPQRQAGPPQATRQTSVSGPAPPKASGAPPGGQQRQGPPQKPPGPAGPTRQASQAGPVPRTGPPTTQQPRPSGPGPAGRPKPQLAQKPSQDVPPPATAAAGGPPHPQLNKSQSLTNAFNLPEPAPPRPSLSQDEVKAETIRSLRKSFASLFSD

Target ORF information:

RefSeq Version	NM_006950.3
Organism	Homo sapiens(human)
Definition	Homo sapiens synapsin I (SYN1), transcript variant Ia, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006950.3

ORF Insert Sequence:

ATGAACTACC TGCGGCGCCG CCTGTCGGAC AGCAACTTTA TGGCCAATCT GCCAAATGGG 
TACATGACAG ACCTGCAGCG TCCGCAGCCG CCCCCACCGC CGCCCGGTGC CCACAGCCCC 
GGAGCCACGC CCGGTCCCGG GACCGCCACT GCCGAGAGGT CCTCCGGGGT CGCCCCAGCG 
GCCTCTCCGG CCGCCCCTAG CCCCGGGTCC TCGGGGGGCG GTGGCTTCTT CTCGTCGCTG 
TCCAACGCGG TCAAGCAGAC CACGGCGGCG GCAGCTGCCA CCTTCAGCGA GCAGGTGGGC 
GGCGGCTCTG GGGGCGCAGG CCGCGGGGGA GCCGCCTCCA GGGTGCTGCT GGTCATCGAC 
GAGCCGCACA CCGACTGGGC AAAATACTTC AAAGGGAAAA AGATCCATGG AGAAATTGAC 
ATTAAAGTAG AACAGGCCGA ATTCTCTGAT CTCAACCTTG TGGCCCATGC CAATGGTGGA 
TTCTCTGTGG ATATGGAAGT TCTTCGGAAT GGGGTGAAGG TCGTGCGGTC TCTGAAGCCG 
GATTTTGTGC TGATCCGCCA GCACGCCTTC AGCATGGCAC GCAACGGAGA CTACCGCAGT 
TTGGTCATTG GGCTGCAGTA TGCTGGAATC CCCAGTGTTA ACTCCTTGCA TTCTGTCTAC 
AACTTCTGTG ACAAGCCCTG GGTGTTTGCC CAGATGGTTC GACTGCATAA GAAACTGGGG 
ACAGAAGAAT TCCCTCTAAT TGATCAGACC TTCTACCCCA ATCACAAAGA AATGCTCAGC 
AGTACAACGT ACCCCGTGGT TGTGAAGATG GGGCACGCAC ACTCTGGGAT GGGCAAGGTC 
AAGGTTGACA ACCAGCATGA CTTCCAGGAC ATCGCAAGTG TCGTGGCACT GACCAAGACG 
TATGCCACTG CCGAGCCCTT CATCGATGCC AAATATGACG TGCGTGTCCA GAAGATTGGG 
CAGAACTACA AGGCCTACAT GAGGACGTCA GTGTCAGGGA ACTGGAAGAC CAATACTGGC 
TCTGCGATGC TGGAGCAAAT TGCCATGTCT GACAGATACA AGCTGTGGGT GGACACGTGC 
TCAGAGATTT TTGGGGGACT GGACATCTGC GCAGTGGAAG CGCTACATGG CAAGGACGGA 
AGGGATCACA TCATTGAGGT GGTGGGTTCC TCCATGCCGC TCATTGGTGA CCACCAGGAT 
GAAGACAAAC AGCTCATCGT AGAGCTCGTG GTCAACAAGA TGGCTCAGGC CCTGCCCCGG 
CAGCGACAGC GGGATGCCTC CCCTGGCAGG GGCTCCCATG GCCAGACTCC GTCCCCAGGG 
GCCCTGCCCT TGGGCCGCCA GACCTCCCAG CAGCCCGCAG GGCCCCCGGC TCAGCAGCGA 
CCCCCACCAC AGGGCGGCCC TCCACAGCCG GGTCCAGGCC CCCAGCGCCA GGGACCCCCA 
TTGCAGCAGC GCCCGCCCCC GCAGGGCCAG CAGCACCTTT CAGGCCTTGG ACCCCCAGCT 
GGCAGCCCCC TGCCCCAGCG CCTTCCAAGT CCCACCTCAG CGCCCCAGCA GCCCGCGTCC 
CAGGCCGCGC CGCCGACCCA GGGTCAAGGC CGCCAATCCC GGCCAGTGGC GGGAGGCCCC 
GGGGCGCCTC CAGCAGCCCG CCCGCCCGCC TCTCCGTCTC CCCAGCGCCA GGCGGGCCCC 
CCACAGGCTA CCCGTCAGAC ATCCGTCTCT GGCCCGGCTC CGCCAAAGGC CTCTGGGGCC 
CCACCGGGCG GGCAGCAGCG CCAGGGCCCG CCCCAGAAAC CCCCAGGCCC AGCCGGCCCC 
ACACGCCAGG CCAGCCAGGC GGGTCCCGTG CCCCGCACTG GGCCACCCAC CACGCAGCAG 
CCTCGGCCCA GCGGCCCGGG CCCCGCTGGA CGTCCCAAAC CACAGCTGGC CCAGAAACCC 
AGCCAGGACG TGCCGCCACC CGCCACCGCC GCTGCAGGGG GACCTCCGCA CCCCCAGCTC 
AACAAATCCC AGTCTCTGAC CAATGCCTTC AACCTTCCAG AGCCAGCCCC GCCCAGGCCC 
AGCCTTAGCC AGGACGAGGT GAAAGCTGAG ACCATCCGCA GCCTGAGGAA GTCTTTCGCC 
AGCCTCTTCT CCGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A novel SYN1 missense mutation in non-syndromic X-linked intellectual disability affects synaptic vesicle life cycle, clustering and mobility.
Human molecular genetics26(23)4699-4714(2017 Dec)
Guarnieri FC,Pozzi D,Raimondi A,Fesce R,Valente MM,Delvecchio VS,Van Esch H,Matteoli M,Benfenati F,D'Adamo P,Valtorta F

DNA hypomethylation of Synapsin II CpG islands associates with increased gene expression in bipolar disorder and major depression.
BMC psychiatry16(1)286(2016 08)
Cruceanu C,Kutsarova E,Chen ES,Checknita DR,Nagy C,Lopez JP,Alda M,Rouleau GA,Turecki G

[Development of the Human Olfactory Bulbs in the Prenatal Ontogenesis: an Immunochistochemical Study with Markers of Presynaptic Terminals (anti-SNAP-25, -Synapsin-I, -Synaptophysin)].
Ontogenez46(3)174-85(2015 May-Jun)
Kharlamova AS,Barabanov VM,Saveliev SV

Increased synapsin I expression in cerebral malaria.
International journal of clinical and experimental pathology8(11)13996-4004(2015)
Thonsranoi K,Glaharn S,Punsawad C,Chaisri U,Krudsood S,Viriyavejakul P

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SYN1 cDNA ORF clone, Homo sapiens(human)

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ORF Insert Sequence:

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ORF Insert Sequence:

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