STX4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	STX4
Entrez Gene ID	6810
Full Name	syntaxin 4
Synonyms	STX4A,p35-2
General protein information	Preferred Names syntaxin 4 Names syntaxin-4 renal carcinoma antigen NY-REN-31 syntaxin 4A (placental)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16p11.2
Disorder MIM:	186591

mRNA and Protein(s)

mRNA	Protein	Name
XM_011545925.2	XP_011544227.1	syntaxin-4 isoform X2
NM_001272095.1	NP_001259024.1	syntaxin-4 isoform 1
NM_001272096.1	NP_001259025.1	syntaxin-4 isoform 2
NM_004604.5	NP_004595.2	syntaxin-4 isoform 3
NM_004604.4	NP_004595.2	syntaxin-4 isoform 3
XM_005255521.1	XP_005255578.1	syntaxin-4 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	STX4	NP_004595.2
Canis lupus familiaris (dog)	STX4	XP_547039.2
Danio rerio (zebrafish)	stx4	NP_956515.1
Pan troglodytes (chimpanzee)	STX4	XP_003315122.1
Bos taurus (cattle)	STX4	NP_001030236.1
	LOC704880	XP_001095454.1
Mus musculus (house mouse)	Stx4a	NP_033320.1
Rattus norvegicus (Norway rat)	Stx4	NP_112387.1

Gene Ontology
Bibliography

Related articles in PubMed

?-adrenoceptor activation-increased VAMP-2 and syntaxin-4 in secretory granules are involved in protein secretion of submandibular gland through the PKA/F-actin pathway.
Ding C, Cong X, Zhang Y, Li SL, Wu LL, Yu GY
Bioscience reports(2018 Jan)

Identification of syntaxin 4 as an essential factor for the hepatitis C virus life cycle.
Ren H, Elgner F, Himmelsbach K, Akhras S, Jiang B, Medvedev R, Ploen D, Hildt E
European journal of cell biology96(6)542-552(2017 Sep)

Interaction of Munc18c and syntaxin4 facilitates invadopodium formation and extracellular matrix invasion of tumor cells.
Brasher MI, Martynowicz DM, Grafinger OR, Hucik A, Shanks-Skinner E, Uniacke J, Coppolino MG
The Journal of biological chemistry292(39)16199-16210(2017 09)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest MUNC18C is required for STX4-mediated invadopodium formation and tumor invasion of extracellular matrix; N-terminal STX4 fragment binds to MUNC18C and inhibits interactions of STX4 with synaptosome-associated protein 23 (SNAP23) and vesicle-associated membrane protein 2 (VAMP2). Fibrosarcoma/adenocarcinoma cell lines were used in these studies. (MUNC18C = syntaxin binding protein MUNC18C; STX4 = syntaxin 4)
Title: Interaction of Munc18c and syntaxin4 facilitates invadopodium formation and extracellular matrix invasion of tumor cells.

The analysis revealed three candidate genes GSK3B, PTPN1, STX4 that are differentially expressed in study subjects. GSK3B was highly significant in Ps-T2D (P=0.00018, FR=-26.6), followed by Ps (P=0.0028, FR=-14.5) and T2D groups (P=0.032, FR=-5.9). PTPN1 showed significant association only with PS-T2D (P=0.00027, FR=-8.5). STX4 showed significant association with both Ps (P=0.0002, FR=-20) and Ps-T2D (P=0.0016, FR=-11.2).
Title: De-regulation of diabetic regulatory genes in psoriasis: Deciphering the unsolved riddle.

Syntaxin-4 has a role in mediating exocytosis of pre-docked and newcomer insulin granules underlying biphasic glucose-stimulated insulin secretion in human pancreatic beta cells
Title: Syntaxin-4 mediates exocytosis of pre-docked and newcomer insulin granules underlying biphasic glucose-stimulated insulin secretion in human pancreatic beta cells.

When the expression of STX4 mRNA was inhibited with short or small interfering, or silencing, RNA in macrophages, the survival of Brucella melitensis was significantly reduced.
Title: Blocking the expression of syntaxin 4 interferes with initial phagocytosis of Brucella melitensis in macrophages.

Increased level of SNAP23-Syntaxin4-VAMP7 interaction correlates with decreased Syntaxin4 phosphorylation and trafficking of MT1-MMP to invadopodia during cellular invasion.
Title: SNAP23, Syntaxin4, and vesicle-associated membrane protein 7 (VAMP7) mediate trafficking of membrane type 1-matrix metalloproteinase (MT1-MMP) during invadopodium formation and tumor cell invasion.

The following STX4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the STX4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu14099	NM_004604.5 Latest version!	Homo sapiens syntaxin 4 (STX4), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu14123	NM_001272095.1 Latest version!	Homo sapiens syntaxin 4 (STX4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OHu60802	XM_011545925.2 Latest version!	Homo sapiens syntaxin 4 (STX4), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OHu14132	NM_001272096.1 Latest version!	Homo sapiens syntaxin 4 (STX4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu49182	XM_005255521.1 Latest version!	Homo sapiens syntaxin 4 (STX4), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu14099	NM_004604.4	Homo sapiens syntaxin 4 (STX4), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

STX4 ( NM_004604.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_004595.2 Homo sapiens syntaxin 4 (STX4), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu14099
Clone ID Related Accession (Same CDS sequence)	NM_004604.5 , NM_004604.4
Accession Version	NM_004604.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 894bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-20
Organism	Homo sapiens(human)
Product	syntaxin-4 isoform 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BI755734.1 and BC002436.2. On Nov 23, 2018 this sequence version replaced NM_004604.4. Transcript Variant: This variant (3) initiates translation at an alternate downstream start codon and uses alternate splice sites at internal exons, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is longer than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.285293.1, SRR3476690.1061790.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000313843.8/ ENSP00000317714.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCGGGACA GGACCCACGA GCTGAGACAG GGGGATGACA GCTCGGACGA AGAGGACAAG 
GAGCGGGTCG CGCTGGTGGT GCACCCGGGC ACGGCACGGC TGGGGAGCCC GGACGAGGAG 
TTCTTCCACA AGGTCCGGAC AATTCGGCAG ACTATTGTCA AACTGGGGAA TAAAGTCCAG 
GAGTTGGAGA AACAGCAGGT CACCATCCTG GCCACGCCCC TTCCCGAGGA GAGCATGAAG 
CAGGAGCTGC AGAACCTGCG CGATGAGATC AAACAGCTGG GGAGGGAGAT CCGCCTGCAG 
CTGAAGGCCA TAGAGCCCCA GAAGGAGGAA GCTGATGAGA ACTATAACTC CGTCAACACA 
AGAATGAGAA AAACCCAGCA TGGGGTCCTG TCCCAGCAAT TCGTGGAGCT CATCAACAAG 
TGCAATTCAA TGCAGTCCGA ATACCGGGAG AAGAACGTGG AGCGGATTCG GAGGCAGCTG 
AAGATCACCA ATGCTGGGAT GGTGTCTGAT GAGGAGTTGG AGCAGATGCT GGACAGTGGG 
CAAAGCGAGG TGTTTGTGTC CAATATCCTG AAGGACACGC AGGTGACTCG ACAGGCCTTA 
AATGAGATCT CGGCCCGGCA CAGTGAGATC CAGCAGCTTG AACGCAGTAT TCGTGAGCTG 
CACGACATAT TCACTTTTCT GGCTACCGAA GTGGAGATGC AGGGGGAGAT GATCAATCGG 
ATTGAGAAGA ACATCCTGAG CTCAGCGGAC TACGTGGAAC GTGGGCAGGA GCACGTCAAG 
ACGGCCCTGG AGAACCAGAA GAAGGCGAGG AAGAAGAAAG TCTTGATTGC CATCTGTGTG 
TCCATCACCG TCGTCCTCCT AGCAGTCATC ATTGGCGTCA CAGTGGTTGG ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004595.2
CDS	249..1142
Translation	MRDRTHELRQGDDSSDEEDKERVALVVHPGTARLGSPDEEFFHKVRTIRQTIVKLGNKVQELEKQQVTILATPLPEESMKQELQNLRDEIKQLGREIRLQLKAIEPQKEEADENYNSVNTRMRKTQHGVLSQQFVELINKCNSMQSEYREKNVERIRRQLKITNAGMVSDEELEQMLDSGQSEVFVSNILKDTQVTRQALNEISARHSEIQQLERSIRELHDIFTFLATEVEMQGEMINRIEKNILSSADYVERGQEHVKTALENQKKARKKKVLIAICVSITVVLLAVIIGVTVVG

Target ORF information:

RefSeq Version	NM_004604.5
Organism	Homo sapiens(human)
Definition	Homo sapiens syntaxin 4 (STX4), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004604.5

ORF Insert Sequence:

ATGCGGGACA GGACCCACGA GCTGAGACAG GGGGATGACA GCTCGGACGA AGAGGACAAG 
GAGCGGGTCG CGCTGGTGGT GCACCCGGGC ACGGCACGGC TGGGGAGCCC GGACGAGGAG 
TTCTTCCACA AGGTCCGGAC AATTCGGCAG ACTATTGTCA AACTGGGGAA TAAAGTCCAG 
GAGTTGGAGA AACAGCAGGT CACCATCCTG GCCACGCCCC TTCCCGAGGA GAGCATGAAG 
CAGGAGCTGC AGAACCTGCG CGATGAGATC AAACAGCTGG GGAGGGAGAT CCGCCTGCAG 
CTGAAGGCCA TAGAGCCCCA GAAGGAGGAA GCTGATGAGA ACTATAACTC CGTCAACACA 
AGAATGAGAA AAACCCAGCA TGGGGTCCTG TCCCAGCAAT TCGTGGAGCT CATCAACAAG 
TGCAATTCAA TGCAGTCCGA ATACCGGGAG AAGAACGTGG AGCGGATTCG GAGGCAGCTG 
AAGATCACCA ATGCTGGGAT GGTGTCTGAT GAGGAGTTGG AGCAGATGCT GGACAGTGGG 
CAAAGCGAGG TGTTTGTGTC CAATATCCTG AAGGACACGC AGGTGACTCG ACAGGCCTTA 
AATGAGATCT CGGCCCGGCA CAGTGAGATC CAGCAGCTTG AACGCAGTAT TCGTGAGCTG 
CACGACATAT TCACTTTTCT GGCTACCGAA GTGGAGATGC AGGGGGAGAT GATCAATCGG 
ATTGAGAAGA ACATCCTGAG CTCAGCGGAC TACGTGGAAC GTGGGCAGGA GCACGTCAAG 
ACGGCCCTGG AGAACCAGAA GAAGGCGAGG AAGAAGAAAG TCTTGATTGC CATCTGTGTG 
TCCATCACCG TCGTCCTCCT AGCAGTCATC ATTGGCGTCA CAGTGGTTGG ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

STX4 ( NM_004604.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004595.2 Homo sapiens syntaxin 4 (STX4), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu14099
Clone ID Related Accession (Same CDS sequence)	NM_004604.5 , NM_004604.4
Accession Version	NM_004604.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 894bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-23
Organism	Homo sapiens(human)
Product	syntaxin-4 isoform 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BI755734.1, BC002436.2 and BQ775670.1. On Jan 20, 2013 this sequence version replaced NM_004604.3. Transcript Variant: This variant (3) initiates translation at an alternate downstream start codon and uses alternate splice sites at internal exons, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is longer than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U07158.1, SRR1163657.229049.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCGGGACA GGACCCACGA GCTGAGACAG GGGGATGACA GCTCGGACGA AGAGGACAAG 
GAGCGGGTCG CGCTGGTGGT GCACCCGGGC ACGGCACGGC TGGGGAGCCC GGACGAGGAG 
TTCTTCCACA AGGTCCGGAC AATTCGGCAG ACTATTGTCA AACTGGGGAA TAAAGTCCAG 
GAGTTGGAGA AACAGCAGGT CACCATCCTG GCCACGCCCC TTCCCGAGGA GAGCATGAAG 
CAGGAGCTGC AGAACCTGCG CGATGAGATC AAACAGCTGG GGAGGGAGAT CCGCCTGCAG 
CTGAAGGCCA TAGAGCCCCA GAAGGAGGAA GCTGATGAGA ACTATAACTC CGTCAACACA 
AGAATGAGAA AAACCCAGCA TGGGGTCCTG TCCCAGCAAT TCGTGGAGCT CATCAACAAG 
TGCAATTCAA TGCAGTCCGA ATACCGGGAG AAGAACGTGG AGCGGATTCG GAGGCAGCTG 
AAGATCACCA ATGCTGGGAT GGTGTCTGAT GAGGAGTTGG AGCAGATGCT GGACAGTGGG 
CAAAGCGAGG TGTTTGTGTC CAATATCCTG AAGGACACGC AGGTGACTCG ACAGGCCTTA 
AATGAGATCT CGGCCCGGCA CAGTGAGATC CAGCAGCTTG AACGCAGTAT TCGTGAGCTG 
CACGACATAT TCACTTTTCT GGCTACCGAA GTGGAGATGC AGGGGGAGAT GATCAATCGG 
ATTGAGAAGA ACATCCTGAG CTCAGCGGAC TACGTGGAAC GTGGGCAGGA GCACGTCAAG 
ACGGCCCTGG AGAACCAGAA GAAGGCGAGG AAGAAGAAAG TCTTGATTGC CATCTGTGTG 
TCCATCACCG TCGTCCTCCT AGCAGTCATC ATTGGCGTCA CAGTGGTTGG ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004595.2
CDS	316..1209
Translation	MRDRTHELRQGDDSSDEEDKERVALVVHPGTARLGSPDEEFFHKVRTIRQTIVKLGNKVQELEKQQVTILATPLPEESMKQELQNLRDEIKQLGREIRLQLKAIEPQKEEADENYNSVNTRMRKTQHGVLSQQFVELINKCNSMQSEYREKNVERIRRQLKITNAGMVSDEELEQMLDSGQSEVFVSNILKDTQVTRQALNEISARHSEIQQLERSIRELHDIFTFLATEVEMQGEMINRIEKNILSSADYVERGQEHVKTALENQKKARKKKVLIAICVSITVVLLAVIIGVTVVG

Target ORF information:

RefSeq Version	NM_004604.4
Organism	Homo sapiens(human)
Definition	Homo sapiens syntaxin 4 (STX4), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004604.4

ORF Insert Sequence:

ATGCGGGACA GGACCCACGA GCTGAGACAG GGGGATGACA GCTCGGACGA AGAGGACAAG 
GAGCGGGTCG CGCTGGTGGT GCACCCGGGC ACGGCACGGC TGGGGAGCCC GGACGAGGAG 
TTCTTCCACA AGGTCCGGAC AATTCGGCAG ACTATTGTCA AACTGGGGAA TAAAGTCCAG 
GAGTTGGAGA AACAGCAGGT CACCATCCTG GCCACGCCCC TTCCCGAGGA GAGCATGAAG 
CAGGAGCTGC AGAACCTGCG CGATGAGATC AAACAGCTGG GGAGGGAGAT CCGCCTGCAG 
CTGAAGGCCA TAGAGCCCCA GAAGGAGGAA GCTGATGAGA ACTATAACTC CGTCAACACA 
AGAATGAGAA AAACCCAGCA TGGGGTCCTG TCCCAGCAAT TCGTGGAGCT CATCAACAAG 
TGCAATTCAA TGCAGTCCGA ATACCGGGAG AAGAACGTGG AGCGGATTCG GAGGCAGCTG 
AAGATCACCA ATGCTGGGAT GGTGTCTGAT GAGGAGTTGG AGCAGATGCT GGACAGTGGG 
CAAAGCGAGG TGTTTGTGTC CAATATCCTG AAGGACACGC AGGTGACTCG ACAGGCCTTA 
AATGAGATCT CGGCCCGGCA CAGTGAGATC CAGCAGCTTG AACGCAGTAT TCGTGAGCTG 
CACGACATAT TCACTTTTCT GGCTACCGAA GTGGAGATGC AGGGGGAGAT GATCAATCGG 
ATTGAGAAGA ACATCCTGAG CTCAGCGGAC TACGTGGAAC GTGGGCAGGA GCACGTCAAG 
ACGGCCCTGG AGAACCAGAA GAAGGCGAGG AAGAAGAAAG TCTTGATTGC CATCTGTGTG 
TCCATCACCG TCGTCCTCCT AGCAGTCATC ATTGGCGTCA CAGTGGTTGG ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

STX4 ( NM_001272095.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001259024.1 Homo sapiens syntaxin 4 (STX4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu14123
Clone ID Related Accession (Same CDS sequence)	NM_001272095.1
Accession Version	NM_001272095.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 660bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-20
Organism	Homo sapiens(human)
Product	syntaxin-4 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BI755734.1, AK296652.1 and BQ775670.1. Transcript Variant: This variant (1) represents the longest transcript and encodes the shortest protein (isoform 1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.402000.1, AK296652.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGCAGG AGCTGCAGAA CCTGCGCGAT GAGATCAAAC AGCTGGGGAG GGAGATCCGC 
CTGCAGCTGA AGGCCATAGA GCCCCAGAAG GAGGAAGCTG ATGAGAACTA TAACTCCGTC 
AACACAAGAA TGAGAAAAAC CCAGCATGGG GTCCTGTCCC AGCAATTCGT GGAGCTCATC 
AACAAGTGCA ATTCAATGCA GTCCGAATAC CGGGAGAAGA ACGTGGAGCG GATTCGGAGG 
CAGCTGAAGA TCACCAATGC TGGGATGGTG TCTGATGAGG AGTTGGAGCA GATGCTGGAC 
AGTGGGCAAA GCGAGGTGTT TGTGTCCAAT ATCCTGAAGG ACACGCAGGT GACTCGACAG 
GCCTTAAATG AGATCTCGGC CCGGCACAGT GAGATCCAGC AGCTTGAACG CAGTATTCGT 
GAGCTGCACG ACATATTCAC TTTTCTGGCT ACCGAAGTGG AGATGCAGGG GGAGATGATC 
AATCGGATTG AGAAGAACAT CCTGAGCTCA GCGGACTACG TGGAACGTGG GCAGGAGCAC 
GTCAAGACGG CCCTGGAGAA CCAGAAGAAG GCGAGGAAGA AGAAAGTCTT GATTGCCATC 
TGTGTGTCCA TCACCGTCGT CCTCCTAGCA GTCATCATTG GCGTCACAGT GGTTGGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001259024.1
CDS	686..1345
Translation	MKQELQNLRDEIKQLGREIRLQLKAIEPQKEEADENYNSVNTRMRKTQHGVLSQQFVELINKCNSMQSEYREKNVERIRRQLKITNAGMVSDEELEQMLDSGQSEVFVSNILKDTQVTRQALNEISARHSEIQQLERSIRELHDIFTFLATEVEMQGEMINRIEKNILSSADYVERGQEHVKTALENQKKARKKKVLIAICVSITVVLLAVIIGVTVVG

Target ORF information:

RefSeq Version	NM_001272095.1
Organism	Homo sapiens(human)
Definition	Homo sapiens syntaxin 4 (STX4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001272095.1

ORF Insert Sequence:

ATGAAGCAGG AGCTGCAGAA CCTGCGCGAT GAGATCAAAC AGCTGGGGAG GGAGATCCGC 
CTGCAGCTGA AGGCCATAGA GCCCCAGAAG GAGGAAGCTG ATGAGAACTA TAACTCCGTC 
AACACAAGAA TGAGAAAAAC CCAGCATGGG GTCCTGTCCC AGCAATTCGT GGAGCTCATC 
AACAAGTGCA ATTCAATGCA GTCCGAATAC CGGGAGAAGA ACGTGGAGCG GATTCGGAGG 
CAGCTGAAGA TCACCAATGC TGGGATGGTG TCTGATGAGG AGTTGGAGCA GATGCTGGAC 
AGTGGGCAAA GCGAGGTGTT TGTGTCCAAT ATCCTGAAGG ACACGCAGGT GACTCGACAG 
GCCTTAAATG AGATCTCGGC CCGGCACAGT GAGATCCAGC AGCTTGAACG CAGTATTCGT 
GAGCTGCACG ACATATTCAC TTTTCTGGCT ACCGAAGTGG AGATGCAGGG GGAGATGATC 
AATCGGATTG AGAAGAACAT CCTGAGCTCA GCGGACTACG TGGAACGTGG GCAGGAGCAC 
GTCAAGACGG CCCTGGAGAA CCAGAAGAAG GCGAGGAAGA AGAAAGTCTT GATTGCCATC 
TGTGTGTCCA TCACCGTCGT CCTCCTAGCA GTCATCATTG GCGTCACAGT GGTTGGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

STX4 ( XM_011545925.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011544227.1 Homo sapiens syntaxin 4 (STX4), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu60802
Clone ID Related Accession (Same CDS sequence)	XM_011545925.2
Accession Version	XM_011545925.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 465bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	syntaxin-4 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000016.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011545925.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAGTCCG AATACCGGGA GAAGAACGTG GAGCGGATTC GGAGGCAGCT GAAGATCACC 
AATGCTGGGA TGGTGTCTGA TGAGGAGTTG GAGCAGATGC TGGACAGTGG GCAAAGCGAG 
GTGTTTGTGT CCAATATCCT GAAGGACACG CAGGTGACTC GACAGGCCTT AAATGAGATC 
TCGGCCCGGC ACAGTGAGAT CCAGCAGCTT GAACGCAGTA TTCGTGAGCT GCACGACATA 
TTCACTTTTC TGGCTACCGA AGTGGAGATG CAGGGGGAGA TGATCAATCG GATTGAGAAG 
AACATCCTGA GCTCAGCGGA CTACGTGGAA CGTGGGCAGG AGCACGTCAA GACGGCCCTG 
GAGAACCAGA AGAAGGCGAG GAAGAAGAAA GTCTTGATTG CCATCTGTGT GTCCATCACC 
GTCGTCCTCC TAGCAGTCAT CATTGGCGTC ACAGTGGTTG GATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011544227.1
CDS	171..635
Translation	MQSEYREKNVERIRRQLKITNAGMVSDEELEQMLDSGQSEVFVSNILKDTQVTRQALNEISARHSEIQQLERSIRELHDIFTFLATEVEMQGEMINRIEKNILSSADYVERGQEHVKTALENQKKARKKKVLIAICVSITVVLLAVIIGVTVVG

Target ORF information:

RefSeq Version	XM_011545925.2
Organism	Homo sapiens(human)
Definition	Homo sapiens syntaxin 4 (STX4), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011545925.2

ORF Insert Sequence:

ATGCAGTCCG AATACCGGGA GAAGAACGTG GAGCGGATTC GGAGGCAGCT GAAGATCACC 
AATGCTGGGA TGGTGTCTGA TGAGGAGTTG GAGCAGATGC TGGACAGTGG GCAAAGCGAG 
GTGTTTGTGT CCAATATCCT GAAGGACACG CAGGTGACTC GACAGGCCTT AAATGAGATC 
TCGGCCCGGC ACAGTGAGAT CCAGCAGCTT GAACGCAGTA TTCGTGAGCT GCACGACATA 
TTCACTTTTC TGGCTACCGA AGTGGAGATG CAGGGGGAGA TGATCAATCG GATTGAGAAG 
AACATCCTGA GCTCAGCGGA CTACGTGGAA CGTGGGCAGG AGCACGTCAA GACGGCCCTG 
GAGAACCAGA AGAAGGCGAG GAAGAAGAAA GTCTTGATTG CCATCTGTGT GTCCATCACC 
GTCGTCCTCC TAGCAGTCAT CATTGGCGTC ACAGTGGTTG GATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

STX4 ( NM_001272096.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001259025.1 Homo sapiens syntaxin 4 (STX4), transcript variant 2, mRNA.

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CloneID	OHu14132
Clone ID Related Accession (Same CDS sequence)	NM_001272096.1
Accession Version	NM_001272096.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 888bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-20
Organism	Homo sapiens(human)
Product	syntaxin-4 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK091833.1, BC002436.2 and BQ775670.1. Transcript Variant: This variant (2) contains a distinct 5' UTR, initiates translation at an alternate upstream start codon and uses alternate splice sites at internal exons, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is longer than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK091833.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGATGA CAGCTCGGAC GAAGAGGACA AGGAGCGGGT CGCGCTGGTG GTGCACCCGG 
GCACGGCACG GCTGGGGAGC CCGGACGAGG AGTTCTTCCA CAAGCCCTCT CGGTCACCCT 
CCCCAGGTCC GGACAATTCG GCAGACTATT GTCAAACTGG GGAATAAAGT CCAGGAGTTG 
GAGAAACAGC AGGTCACCAT CCTGGCCACG CCCCTTCCCG AGGAGAGCAT GAAGCAGGAG 
CTGCAGAACC TGCGCGATGA GATCAAACAG CTGGGGAGGG AGATCCGCCT GCAGCTGAAG 
GCCATAGAGC CCCAGAAGGA GGAAGCTGAT GAGAACTATA ACTCCGTCAA CACAAGAATG 
AGAAAAACCC AGCATGGGGT CCTGTCCCAG CAATTCGTGG AGCTCATCAA CAAGTGCAAT 
TCAATGCAGT CCGAATACCG GGAGAAGAAC GTGGAGCGGA TTCGGAGGCA GCTGAAGATC 
ACCAATGCTG GGATGGTGTC TGATGAGGAG TTGGAGCAGA TGCTGGACAG TGGGCAAAGC 
GAGGTGTTTG TGTCCAATAT CCTGAAGGAC ACGCAGGTGA CTCGACAGGC CTTAAATGAG 
ATCTCGGCCC GGCACAGTGA GATCCAGCAG CTTGAACGCA GTATTCGTGA GCTGCACGAC 
ATATTCACTT TTCTGGCTAC CGAAGTGGAG ATGCAGGGGG AGATGATCAA TCGGATTGAG 
AAGAACATCC TGAGCTCAGC GGACTACGTG GAACGTGGGC AGGAGCACGT CAAGACGGCC 
CTGGAGAACC AGAAGAAGGC GAGGAAGAAG AAAGTCTTGA TTGCCATCTG TGTGTCCATC 
ACCGTCGTCC TCCTAGCAGT CATCATTGGC GTCACAGTGG TTGGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001259025.1
CDS	344..1231
Translation	MGMTARTKRTRSGSRWWCTRARHGWGARTRSSSTSPLGHPPQVRTIRQTIVKLGNKVQELEKQQVTILATPLPEESMKQELQNLRDEIKQLGREIRLQLKAIEPQKEEADENYNSVNTRMRKTQHGVLSQQFVELINKCNSMQSEYREKNVERIRRQLKITNAGMVSDEELEQMLDSGQSEVFVSNILKDTQVTRQALNEISARHSEIQQLERSIRELHDIFTFLATEVEMQGEMINRIEKNILSSADYVERGQEHVKTALENQKKARKKKVLIAICVSITVVLLAVIIGVTVVG

Target ORF information:

RefSeq Version	NM_001272096.1
Organism	Homo sapiens(human)
Definition	Homo sapiens syntaxin 4 (STX4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001272096.1

ORF Insert Sequence:

ATGGGGATGA CAGCTCGGAC GAAGAGGACA AGGAGCGGGT CGCGCTGGTG GTGCACCCGG 
GCACGGCACG GCTGGGGAGC CCGGACGAGG AGTTCTTCCA CAAGCCCTCT CGGTCACCCT 
CCCCAGGTCC GGACAATTCG GCAGACTATT GTCAAACTGG GGAATAAAGT CCAGGAGTTG 
GAGAAACAGC AGGTCACCAT CCTGGCCACG CCCCTTCCCG AGGAGAGCAT GAAGCAGGAG 
CTGCAGAACC TGCGCGATGA GATCAAACAG CTGGGGAGGG AGATCCGCCT GCAGCTGAAG 
GCCATAGAGC CCCAGAAGGA GGAAGCTGAT GAGAACTATA ACTCCGTCAA CACAAGAATG 
AGAAAAACCC AGCATGGGGT CCTGTCCCAG CAATTCGTGG AGCTCATCAA CAAGTGCAAT 
TCAATGCAGT CCGAATACCG GGAGAAGAAC GTGGAGCGGA TTCGGAGGCA GCTGAAGATC 
ACCAATGCTG GGATGGTGTC TGATGAGGAG TTGGAGCAGA TGCTGGACAG TGGGCAAAGC 
GAGGTGTTTG TGTCCAATAT CCTGAAGGAC ACGCAGGTGA CTCGACAGGC CTTAAATGAG 
ATCTCGGCCC GGCACAGTGA GATCCAGCAG CTTGAACGCA GTATTCGTGA GCTGCACGAC 
ATATTCACTT TTCTGGCTAC CGAAGTGGAG ATGCAGGGGG AGATGATCAA TCGGATTGAG 
AAGAACATCC TGAGCTCAGC GGACTACGTG GAACGTGGGC AGGAGCACGT CAAGACGGCC 
CTGGAGAACC AGAAGAAGGC GAGGAAGAAG AAAGTCTTGA TTGCCATCTG TGTGTCCATC 
ACCGTCGTCC TCCTAGCAGT CATCATTGGC GTCACAGTGG TTGGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

STX4 ( XM_005255521.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_005255578.1 Homo sapiens syntaxin 4 (STX4), transcript variant X3, mRNA.

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CloneID	OHu49182
Clone ID Related Accession (Same CDS sequence)	XM_005255521.1
Accession Version	XM_005255521.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 882bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	syntaxin-4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000016.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACAGCTC GGACGAAGAG GACAAGGAGC GGGTCGCGCT GGTGGTGCAC CCGGGCACGG 
CACGGCTGGG GAGCCCGGAC GAGGAGTTCT TCCACAAGCC CTCTCGGTCA CCCTCCCCAG 
GTCCGGACAA TTCGGCAGAC TATTGTCAAA CTGGGGAATA AAGTCCAGGA GTTGGAGAAA 
CAGCAGGTCA CCATCCTGGC CACGCCCCTT CCCGAGGAGA GCATGAAGCA GGAGCTGCAG 
AACCTGCGCG ATGAGATCAA ACAGCTGGGG AGGGAGATCC GCCTGCAGCT GAAGGCCATA 
GAGCCCCAGA AGGAGGAAGC TGATGAGAAC TATAACTCCG TCAACACAAG AATGAGAAAA 
ACCCAGCATG GGGTCCTGTC CCAGCAATTC GTGGAGCTCA TCAACAAGTG CAATTCAATG 
CAGTCCGAAT ACCGGGAGAA GAACGTGGAG CGGATTCGGA GGCAGCTGAA GATCACCAAT 
GCTGGGATGG TGTCTGATGA GGAGTTGGAG CAGATGCTGG ACAGTGGGCA AAGCGAGGTG 
TTTGTGTCCA ATATCCTGAA GGACACGCAG GTGACTCGAC AGGCCTTAAA TGAGATCTCG 
GCCCGGCACA GTGAGATCCA GCAGCTTGAA CGCAGTATTC GTGAGCTGCA CGACATATTC 
ACTTTTCTGG CTACCGAAGT GGAGATGCAG GGGGAGATGA TCAATCGGAT TGAGAAGAAC 
ATCCTGAGCT CAGCGGACTA CGTGGAACGT GGGCAGGAGC ACGTCAAGAC GGCCCTGGAG 
AACCAGAAGA AGGCGAGGAA GAAGAAAGTC TTGATTGCCA TCTGTGTGTC CATCACCGTC 
GTCCTCCTAG CAGTCATCAT TGGCGTCACA GTGGTTGGAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005255578.1
CDS	245..1126
Translation	MTARTKRTRSGSRWWCTRARHGWGARTRSSSTSPLGHPPQVRTIRQTIVKLGNKVQELEKQQVTILATPLPEESMKQELQNLRDEIKQLGREIRLQLKAIEPQKEEADENYNSVNTRMRKTQHGVLSQQFVELINKCNSMQSEYREKNVERIRRQLKITNAGMVSDEELEQMLDSGQSEVFVSNILKDTQVTRQALNEISARHSEIQQLERSIRELHDIFTFLATEVEMQGEMINRIEKNILSSADYVERGQEHVKTALENQKKARKKKVLIAICVSITVVLLAVIIGVTVVG

Target ORF information:

RefSeq Version	XM_005255521.1
Organism	Homo sapiens(human)
Definition	Homo sapiens syntaxin 4 (STX4), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005255521.1

ORF Insert Sequence:

ATGACAGCTC GGACGAAGAG GACAAGGAGC GGGTCGCGCT GGTGGTGCAC CCGGGCACGG 
CACGGCTGGG GAGCCCGGAC GAGGAGTTCT TCCACAAGCC CTCTCGGTCA CCCTCCCCAG 
GTCCGGACAA TTCGGCAGAC TATTGTCAAA CTGGGGAATA AAGTCCAGGA GTTGGAGAAA 
CAGCAGGTCA CCATCCTGGC CACGCCCCTT CCCGAGGAGA GCATGAAGCA GGAGCTGCAG 
AACCTGCGCG ATGAGATCAA ACAGCTGGGG AGGGAGATCC GCCTGCAGCT GAAGGCCATA 
GAGCCCCAGA AGGAGGAAGC TGATGAGAAC TATAACTCCG TCAACACAAG AATGAGAAAA 
ACCCAGCATG GGGTCCTGTC CCAGCAATTC GTGGAGCTCA TCAACAAGTG CAATTCAATG 
CAGTCCGAAT ACCGGGAGAA GAACGTGGAG CGGATTCGGA GGCAGCTGAA GATCACCAAT 
GCTGGGATGG TGTCTGATGA GGAGTTGGAG CAGATGCTGG ACAGTGGGCA AAGCGAGGTG 
TTTGTGTCCA ATATCCTGAA GGACACGCAG GTGACTCGAC AGGCCTTAAA TGAGATCTCG 
GCCCGGCACA GTGAGATCCA GCAGCTTGAA CGCAGTATTC GTGAGCTGCA CGACATATTC 
ACTTTTCTGG CTACCGAAGT GGAGATGCAG GGGGAGATGA TCAATCGGAT TGAGAAGAAC 
ATCCTGAGCT CAGCGGACTA CGTGGAACGT GGGCAGGAGC ACGTCAAGAC GGCCCTGGAG 
AACCAGAAGA AGGCGAGGAA GAAGAAAGTC TTGATTGCCA TCTGTGTGTC CATCACCGTC 
GTCCTCCTAG CAGTCATCAT TGGCGTCACA GTGGTTGGAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

?-adrenoceptor activation-increased VAMP-2 and syntaxin-4 in secretory granules are involved in protein secretion of submandibular gland through the PKA/F-actin pathway.
Bioscience reports(2018 Jan)
Ding C,Cong X,Zhang Y,Li SL,Wu LL,Yu GY

Identification of syntaxin 4 as an essential factor for the hepatitis C virus life cycle.
European journal of cell biology96(6)542-552(2017 Sep)
Ren H,Elgner F,Himmelsbach K,Akhras S,Jiang B,Medvedev R,Ploen D,Hildt E

Interaction of Munc18c and syntaxin4 facilitates invadopodium formation and extracellular matrix invasion of tumor cells.
The Journal of biological chemistry292(39)16199-16210(2017 09)
Brasher MI,Martynowicz DM,Grafinger OR,Hucik A,Shanks-Skinner E,Uniacke J,Coppolino MG

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STX4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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