STK10 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	STK10
Entrez Gene ID	6793
Full Name	serine/threonine kinase 10
Synonyms	LOK,PRO2729
General protein information	Preferred Names serine/threonine kinase 10 Names serine/threonine-protein kinase 10 lymphocyte-oriented kinase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q35.1
Summary	This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. [provided by RefSeq, Jul 2008].
Disorder MIM:	603919

mRNA and Protein(s)

mRNA	Protein	Name
XM_017009788.1	XP_016865277.1	serine/threonine-protein kinase 10 isoform X1
NM_005990.3	NP_005981.3	serine/threonine-protein kinase 10
NM_005990.4	NP_005981.3	serine/threonine-protein kinase 10

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	STK10	XP_546239.2
Bos taurus (cattle)	STK10	NP_001179556.1
Rattus norvegicus (Norway rat)	Stk10	NP_062079.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010551	XP_314524.4
Homo sapiens (human)	STK10	NP_005981.3
	STK10	XP_002804682.1
Gallus gallus (chicken)	STK10	XP_414529.4
Caenorhabditis elegans (roundworm)	gck-4	NP_510290.1
Pan troglodytes (chimpanzee)	STK10	XP_518098.4
Mus musculus (house mouse)	Stk10	NP_033314.2
Danio rerio (zebrafish)	stk10	NP_957427.1
Drosophila melanogaster (fruit fly)	slik	NP_001014549.1
Xenopus tropicalis (tropical clawed frog)	stk10	NP_001072623.1

Gene Ontology
Bibliography

Related articles in PubMed

Ezrin activation by LOK phosphorylation involves a PIP
Pelaseyed T, Viswanatha R, Sauvanet C, Filter JJ, Goldberg ML, Bretscher A
eLife6(2017 04)

Altered mitochondrial expression genes in patients receiving right ventricular apical pacing.
Xu H, Gao J, Wang F
Experimental and molecular pathology100(3)469-75(2016 06)

STK10 missense mutations associated with anti-apoptotic function.
Fukumura K, Yamashita Y, Kawazu M, Sai E, Fujiwara S, Nakamura N, Takeuchi K, Ando M, Miyazono K, Ueno T, Ozawa K, Mano H
Oncology reports30(4)1542-8(2013 Oct)

Genome-wide meta-analysis identifies new susceptibility loci for migraine.
Anttila V, Winsvold BS, Gormley P, Kurth T, Bettella F, McMahon G, Kallela M, Malik R, de Vries B, Terwindt G, Medland SE, Todt U, McArdle WL, Quaye L, Koiranen M, Ikram MA, Lehtim?ki T, Stam AH, Ligthart L, Wedenoja J, Dunham I, Neale BM, Palta P, Hamalainen E, Sch?rks M, Rose LM, Buring JE, Ridker PM, Steinberg S, Stefansson H, Jakobsson F, Lawlor DA, Evans DM, Ring SM, F?rkkil? M, Artto V, Kaunisto MA, Freilinger T, Schoenen J, Frants RR, Pelzer N, Weller CM, Zielman R, Heath AC, Madden PAF, Montgomery GW, Martin NG, Borck G, G?bel H, Heinze A, Heinze-Kuhn K, Williams FMK, Hartikainen AL, Pouta A, van den Ende J, Uitterlinden AG, Hofman A, Amin N, Hottenga JJ, Vink JM, Heikkil? K, Alexander M, Muller-Myhsok B, Schreiber S, Meitinger T, Wichmann HE, Aromaa A, Eriksson JG, Traynor B, Trabzuni D, , , Rossin E, Lage K, Jacobs SBR, Gibbs JR, Birney E, Kaprio J, Penninx BW, Boomsma DI, van Duijn C, Raitakari O, Jarvelin MR, Zwart JA, Cherkas L, Strachan DP, Kubisch C, Ferrari MD, van den Maagdenberg AMJM, Dichgans M, Wessman M, Smith GD, Stefansson K, Daly MJ, Nyholt DR, Chasman D, Palotie A
Nature genetics45(8)912-917(2013 Aug)

Local phosphocycling mediated by LOK/SLK restricts ezrin function to the apical aspect of epithelial cells.
Viswanatha R, Ohouo PY, Smolka MB, Bretscher A
The Journal of cell biology199(6)969-84(2012 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Binding of phosphatidylinositol 4,5-biphosphate to ezrin induces a conformational change permitting the insertion of the LOK C-terminal domain to wedge apart the membrane and F-actin-binding domains of ezrin. The N-terminal LOK kinase domain can then access a site 40 residues distal from the consensus sequence that collectively direct phosphorylation of the appropriate threonine residue.
Title: Ezrin activation by LOK phosphorylation involves a PIP

The gene signature of OPA1, CTSA, NDUFA1, STK10 and PRDX1 was able to identify patients post-implant with a sensitivity of 91% and a specificity of 86% in discrimination between post-implant group and healthy controls.
Title: Altered mitochondrial expression genes in patients receiving right ventricular apical pacing.

STK10 functions as a tumor suppressor gene, and dysfunction of STK10 activity either through polymorphism or somatic mutations may confer anti-apoptotic effects contributing to carcinogenesis.
Title: STK10 missense mutations associated with anti-apoptotic function.

It was shown that lymphocyte-oriented and STE20 kinase were sufficient to restrict ezrin function to the apical domain. Both kinases were enriched in microvilli and locally activated there.
Title: Local phosphocycling mediated by LOK/SLK restricts ezrin function to the apical aspect of epithelial cells.

genetic polymorphism is associated with aspirin-intolerant asthma in a Korean population
Title: Variations in the STK10 gene and possible associations with aspirin-intolerant asthma in a Korean population.

The following STK10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the STK10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu20183	NM_005990.4 Latest version!	Homo sapiens serine/threonine kinase 10 (STK10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu96029	XM_017009788.1 Latest version!	Homo sapiens serine/threonine kinase 10 (STK10), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00
View Old Accession Versions >>
OHu20183	NM_005990.3	Homo sapiens serine/threonine kinase 10 (STK10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

STK10 ( NM_005990.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005981.3 Homo sapiens serine/threonine kinase 10 (STK10), mRNA.

Price & Availability↑

CloneID	OHu20183
Clone ID Related Accession (Same CDS sequence)	NM_005990.3 , NM_005990.4
Accession Version	NM_005990.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2907bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	serine/threonine-protein kinase 10
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA507768.1, BI459912.1, AB015718.1, DB068209.1, AC113342.2 and AI584023.1. On or before Mar 2, 2007 this sequence version replaced XM_001129121.1, NM_005990.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.134568.1, BC070077.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTTTTG CCAATTTCCG CCGCATCCTG CGCCTGTCTA CCTTCGAGAA GAGAAAGTCC 
CGCGAATATG AGCACGTCCG CCGCGACCTG GACCCCAACG AGGTGTGGGA GATCGTGGGC 
GAGCTGGGCG ACGGCGCCTT CGGCAAGGTT TACAAGGCCA AGAATAAGGA GACGGGTGCT 
TTGGCTGCGG CCAAAGTCAT TGAAACCAAG AGTGAGGAGG AGCTGGAGGA CTACATCGTG 
GAGATTGAGA TCCTGGCCAC CTGCGACCAC CCCTACATTG TGAAGCTCCT GGGAGCCTAC 
TATCACGACG GGAAGCTGTG GATCATGATT GAGTTCTGTC CAGGGGGAGC CGTGGACGCC 
ATCATGCTGG AGCTGGACAG AGGCCTCACG GAGCCCCAGA TACAGGTGGT TTGCCGCCAG 
ATGCTAGAAG CCCTCAACTT CCTGCACAGC AAGAGGATCA TCCACCGAGA TCTGAAAGCT 
GGCAACGTGC TGATGACCCT CGAGGGAGAC ATCAGGCTGG CTGACTTTGG TGTGTCTGCC 
AAGAATCTGA AGACTCTACA GAAACGAGAT TCCTTCATCG GCACGCCTTA CTGGATGGCC 
CCCGAGGTGG TCATGTGTGA GACCATGAAA GACACGCCCT ACGACTACAA AGCCGACATC 
TGGTCCCTGG GCATCACGCT GATTGAGATG GCCCAGATCG AGCCGCCACA CCACGAGCTC 
AACCCCATGC GGGTCCTGCT AAAGATCGCC AAGTCGGACC CTCCCACGCT GCTCACGCCC 
TCTAAGTGGT CTGTAGAGTT CCGTGACTTC CTGAAGATAG CCCTGGATAA GAACCCAGAA 
ACCCGACCCA GTGCCGCGCA GCTGCTGGAG CATCCCTTCG TCAGCAGCAT CACCAGTAAC 
AAGGCTCTGC GGGAGCTGGT GGCTGAGGCC AAGGCCGAGG TGATGGAAGA GATCGAAGAC 
GGCCGGGATG AGGGGGAAGA GGAGGACGCC GTGGATGCCG CCTCCACCCT GGAGAACCAT 
ACTCAGAACT CCTCTGAGGT GAGTCCGCCA AGCCTCAATG CTGACAAGCC TCTCGAGGAG 
TCACCTTCCA CCCCGCTGGC ACCCAGCCAG TCTCAGGACA GTGTGAATGA GCCCTGCAGC 
CAGCCCTCTG GGGACAGATC CCTCCAAACC ACCAGTCCCC CAGTCGTGGC CCCTGGAAAT 
GAGAACGGCC TGGCAGTGCC TGTGCCCCTG CGGAAGTCCC GACCCGTGTC AATGGATGCC 
AGAATTCAGG TAGCCCAGGA GAAGCAAGTT GCTGAGCAGG GTGGGGACCT CAGCCCAGCA 
GCCAACAGAT CTCAAAAGGC CAGCCAGAGC CGGCCCAACA GCAGCGCCCT GGAGACCTTG 
GGTGGGGAGA AGCTGGCCAA TGGCAGCCTG GAGCCACCTG CCCAGGCAGC TCCAGGGCCT 
TCCAAGAGGG ACTCGGACTG CAGCAGCCTC TGCACCTCTG AGAGCATGGA CTATGGTACC 
AATCTCTCCA CTGACCTGTC GCTGAACAAA GAGATGGGCT CTCTGTCCAT CAAGGACCCG 
AAACTGTACA AAAAAACCCT CAAGCGGACA CGCAAATTTG TGGTGGATGG TGTGGAGGTG 
AGCATCACCA CCTCCAAGAT CATCAGCGAA GATGAGAAGA AGGATGAGGA GATGAGATTT 
CTCAGGCGCC AGGAACTCCG AGAGCTTCGG CTGCTCCAGA AAGAAGAGCA TCGGAACCAG 
ACCCAGCTGA GTAACAAGCA TGAGCTGCAG CTGGAGCAAA TGCATAAACG TTTTGAACAG 
GAAATCAACG CCAAGAAGAA GTTCTTTGAC ACGGAATTAG AGAACCTGGA GCGTCAGCAA 
AAGCAGCAAG TGGAGAAGAT GGAGCAAGAC CATGCCGTGC GCCGCCGGGA GGAGGCCAGG 
CGGATCCGCC TGGAGCAGGA TCGGGACTAC ACCAGGTTCC AAGAGCAGCT CAAACTGATG 
AAGAAAGAGG TGAAGAACGA GGTGGAGAAG CTCCCCCGAC AGCAGCGGAA GGAAAGCATG 
AAGCAGAAGA TGGAGGAGCA CACGCAGAAA AAGCAGCTTC TTGACCGGGA CTTTGTAGCC 
AAGCAGAAGG AGGACCTGGA GCTGGCCATG AAGAGGCTCA CCACCGACAA CAGGCGGGAG 
ATCTGTGACA AGGAGCGCGA GTGCCTCATG AAGAAGCAGG AGCTCCTTCG AGACCGGGAA 
GCAGCCCTGT GGGAGATGGA AGAGCACCAG CTGCAGGAGA GGCACCAGCT GGTGAAGCAG 
CAGCTCAAAG ACCAGTACTT CCTCCAGCGG CACGAGCTGC TGCGCAAGCA TGAGAAGGAG 
CGGGAGCAGA TGCAGCGCTA CAACCAGCGC ATGATAGAGC AGCTGAAGGT GCGGCAGCAA 
CAGGAAAAGG CGCGGCTGCC CAAGATCCAG AGGAGTGAGG GCAAGACGCG CATGGCCATG 
TACAAGAAGA GCCTCCACAT CAACGGCGGG GGCAGCGCAG CTGAGCAGCG TGAGAAGATC 
AAGCAGTTCT CCCAGCAGGA GGAGAAGAGG CAGAAGTCGG AGCGGCTGCA GCAACAGCAG 
AAACACGAGA ACCAGATGCG GGACATGCTG GCGCAGTGTG AGAGCAACAT GAGCGAGCTG 
CAGCAGCTGC AGAATGAAAA GTGCCACCTC CTGGTAGAGC ACGAAACCCA GAAACTGAAG 
GCCCTGGATG AGAGCCATAA CCAGAACCTG AAGGAATGGC GGGACAAGCT TCGGCCGCGC 
AAGAAGGCTC TGGAAGAGGA TCTGAACCAG AAGAAGCGGG AGCAGGAGAT GTTCTTCAAG 
CTGAGCGAGG AGGCGGAGTG CCCAAACCCC TCCACCCCAA GCAAGGCCGC CAAGTTCTTC 
CCCTACAGTT CTGCGGATGC TTCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005981.3
CDS	301..3207
Translation	MAFANFRRILRLSTFEKRKSREYEHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVMEEIEDGRDEGEEEDAVDAASTLENHTQNSSEVSPPSLNADKPLEESPSTPLAPSQSQDSVNEPCSQPSGDRSLQTTSPPVVAPGNENGLAVPVPLRKSRPVSMDARIQVAQEKQVAEQGGDLSPAANRSQKASQSRPNSSALETLGGEKLANGSLEPPAQAAPGPSKRDSDCSSLCTSESMDYGTNLSTDLSLNKEMGSLSIKDPKLYKKTLKRTRKFVVDGVEVSITTSKIISEDEKKDEEMRFLRRQELRELRLLQKEEHRNQTQLSNKHELQLEQMHKRFEQEINAKKKFFDTELENLERQQKQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQEQLKLMKKEVKNEVEKLPRQQRKESMKQKMEEHTQKKQLLDRDFVAKQKEDLELAMKRLTTDNRREICDKERECLMKKQELLRDREAALWEMEEHQLQERHQLVKQQLKDQYFLQRHELLRKHEKEREQMQRYNQRMIEQLKVRQQQEKARLPKIQRSEGKTRMAMYKKSLHINGGGSAAEQREKIKQFSQQEEKRQKSERLQQQQKHENQMRDMLAQCESNMSELQQLQNEKCHLLVEHETQKLKALDESHNQNLKEWRDKLRPRKKALEEDLNQKKREQEMFFKLSEEAECPNPSTPSKAAKFFPYSSADAS

Target ORF information:

RefSeq Version	NM_005990.3
Organism	Homo sapiens(human)
Definition	Homo sapiens serine/threonine kinase 10 (STK10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005990.3

ORF Insert Sequence:

ATGGCTTTTG CCAATTTCCG CCGCATCCTG CGCCTGTCTA CCTTCGAGAA GAGAAAGTCC 
CGCGAATATG AGCACGTCCG CCGCGACCTG GACCCCAACG AGGTGTGGGA GATCGTGGGC 
GAGCTGGGCG ACGGCGCCTT CGGCAAGGTT TACAAGGCCA AGAATAAGGA GACGGGTGCT 
TTGGCTGCGG CCAAAGTCAT TGAAACCAAG AGTGAGGAGG AGCTGGAGGA CTACATCGTG 
GAGATTGAGA TCCTGGCCAC CTGCGACCAC CCCTACATTG TGAAGCTCCT GGGAGCCTAC 
TATCACGACG GGAAGCTGTG GATCATGATT GAGTTCTGTC CAGGGGGAGC CGTGGACGCC 
ATCATGCTGG AGCTGGACAG AGGCCTCACG GAGCCCCAGA TACAGGTGGT TTGCCGCCAG 
ATGCTAGAAG CCCTCAACTT CCTGCACAGC AAGAGGATCA TCCACCGAGA TCTGAAAGCT 
GGCAACGTGC TGATGACCCT CGAGGGAGAC ATCAGGCTGG CTGACTTTGG TGTGTCTGCC 
AAGAATCTGA AGACTCTACA GAAACGAGAT TCCTTCATCG GCACGCCTTA CTGGATGGCC 
CCCGAGGTGG TCATGTGTGA GACCATGAAA GACACGCCCT ACGACTACAA AGCCGACATC 
TGGTCCCTGG GCATCACGCT GATTGAGATG GCCCAGATCG AGCCGCCACA CCACGAGCTC 
AACCCCATGC GGGTCCTGCT AAAGATCGCC AAGTCGGACC CTCCCACGCT GCTCACGCCC 
TCTAAGTGGT CTGTAGAGTT CCGTGACTTC CTGAAGATAG CCCTGGATAA GAACCCAGAA 
ACCCGACCCA GTGCCGCGCA GCTGCTGGAG CATCCCTTCG TCAGCAGCAT CACCAGTAAC 
AAGGCTCTGC GGGAGCTGGT GGCTGAGGCC AAGGCCGAGG TGATGGAAGA GATCGAAGAC 
GGCCGGGATG AGGGGGAAGA GGAGGACGCC GTGGATGCCG CCTCCACCCT GGAGAACCAT 
ACTCAGAACT CCTCTGAGGT GAGTCCGCCA AGCCTCAATG CTGACAAGCC TCTCGAGGAG 
TCACCTTCCA CCCCGCTGGC ACCCAGCCAG TCTCAGGACA GTGTGAATGA GCCCTGCAGC 
CAGCCCTCTG GGGACAGATC CCTCCAAACC ACCAGTCCCC CAGTCGTGGC CCCTGGAAAT 
GAGAACGGCC TGGCAGTGCC TGTGCCCCTG CGGAAGTCCC GACCCGTGTC AATGGATGCC 
AGAATTCAGG TAGCCCAGGA GAAGCAAGTT GCTGAGCAGG GTGGGGACCT CAGCCCAGCA 
GCCAACAGAT CTCAAAAGGC CAGCCAGAGC CGGCCCAACA GCAGCGCCCT GGAGACCTTG 
GGTGGGGAGA AGCTGGCCAA TGGCAGCCTG GAGCCACCTG CCCAGGCAGC TCCAGGGCCT 
TCCAAGAGGG ACTCGGACTG CAGCAGCCTC TGCACCTCTG AGAGCATGGA CTATGGTACC 
AATCTCTCCA CTGACCTGTC GCTGAACAAA GAGATGGGCT CTCTGTCCAT CAAGGACCCG 
AAACTGTACA AAAAAACCCT CAAGCGGACA CGCAAATTTG TGGTGGATGG TGTGGAGGTG 
AGCATCACCA CCTCCAAGAT CATCAGCGAA GATGAGAAGA AGGATGAGGA GATGAGATTT 
CTCAGGCGCC AGGAACTCCG AGAGCTTCGG CTGCTCCAGA AAGAAGAGCA TCGGAACCAG 
ACCCAGCTGA GTAACAAGCA TGAGCTGCAG CTGGAGCAAA TGCATAAACG TTTTGAACAG 
GAAATCAACG CCAAGAAGAA GTTCTTTGAC ACGGAATTAG AGAACCTGGA GCGTCAGCAA 
AAGCAGCAAG TGGAGAAGAT GGAGCAAGAC CATGCCGTGC GCCGCCGGGA GGAGGCCAGG 
CGGATCCGCC TGGAGCAGGA TCGGGACTAC ACCAGGTTCC AAGAGCAGCT CAAACTGATG 
AAGAAAGAGG TGAAGAACGA GGTGGAGAAG CTCCCCCGAC AGCAGCGGAA GGAAAGCATG 
AAGCAGAAGA TGGAGGAGCA CACGCAGAAA AAGCAGCTTC TTGACCGGGA CTTTGTAGCC 
AAGCAGAAGG AGGACCTGGA GCTGGCCATG AAGAGGCTCA CCACCGACAA CAGGCGGGAG 
ATCTGTGACA AGGAGCGCGA GTGCCTCATG AAGAAGCAGG AGCTCCTTCG AGACCGGGAA 
GCAGCCCTGT GGGAGATGGA AGAGCACCAG CTGCAGGAGA GGCACCAGCT GGTGAAGCAG 
CAGCTCAAAG ACCAGTACTT CCTCCAGCGG CACGAGCTGC TGCGCAAGCA TGAGAAGGAG 
CGGGAGCAGA TGCAGCGCTA CAACCAGCGC ATGATAGAGC AGCTGAAGGT GCGGCAGCAA 
CAGGAAAAGG CGCGGCTGCC CAAGATCCAG AGGAGTGAGG GCAAGACGCG CATGGCCATG 
TACAAGAAGA GCCTCCACAT CAACGGCGGG GGCAGCGCAG CTGAGCAGCG TGAGAAGATC 
AAGCAGTTCT CCCAGCAGGA GGAGAAGAGG CAGAAGTCGG AGCGGCTGCA GCAACAGCAG 
AAACACGAGA ACCAGATGCG GGACATGCTG GCGCAGTGTG AGAGCAACAT GAGCGAGCTG 
CAGCAGCTGC AGAATGAAAA GTGCCACCTC CTGGTAGAGC ACGAAACCCA GAAACTGAAG 
GCCCTGGATG AGAGCCATAA CCAGAACCTG AAGGAATGGC GGGACAAGCT TCGGCCGCGC 
AAGAAGGCTC TGGAAGAGGA TCTGAACCAG AAGAAGCGGG AGCAGGAGAT GTTCTTCAAG 
CTGAGCGAGG AGGCGGAGTG CCCAAACCCC TCCACCCCAA GCAAGGCCGC CAAGTTCTTC 
CCCTACAGTT CTGCGGATGC TTCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

STK10 ( NM_005990.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005981.3 Homo sapiens serine/threonine kinase 10 (STK10), mRNA.

Price & Availability↑

CloneID	OHu20183
Clone ID Related Accession (Same CDS sequence)	NM_005990.3 , NM_005990.4
Accession Version	NM_005990.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2907bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Homo sapiens(human)
Product	serine/threonine-protein kinase 10
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA507768.1, BI459912.1, AB015718.1, DB068209.1, AC113342.2 and AI584023.1. On Nov 22, 2018 this sequence version replaced NM_005990.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.134568.1, BC070077.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000176763.10/ ENSP00000176763.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTTTTG CCAATTTCCG CCGCATCCTG CGCCTGTCTA CCTTCGAGAA GAGAAAGTCC 
CGCGAATATG AGCACGTCCG CCGCGACCTG GACCCCAACG AGGTGTGGGA GATCGTGGGC 
GAGCTGGGCG ACGGCGCCTT CGGCAAGGTT TACAAGGCCA AGAATAAGGA GACGGGTGCT 
TTGGCTGCGG CCAAAGTCAT TGAAACCAAG AGTGAGGAGG AGCTGGAGGA CTACATCGTG 
GAGATTGAGA TCCTGGCCAC CTGCGACCAC CCCTACATTG TGAAGCTCCT GGGAGCCTAC 
TATCACGACG GGAAGCTGTG GATCATGATT GAGTTCTGTC CAGGGGGAGC CGTGGACGCC 
ATCATGCTGG AGCTGGACAG AGGCCTCACG GAGCCCCAGA TACAGGTGGT TTGCCGCCAG 
ATGCTAGAAG CCCTCAACTT CCTGCACAGC AAGAGGATCA TCCACCGAGA TCTGAAAGCT 
GGCAACGTGC TGATGACCCT CGAGGGAGAC ATCAGGCTGG CTGACTTTGG TGTGTCTGCC 
AAGAATCTGA AGACTCTACA GAAACGAGAT TCCTTCATCG GCACGCCTTA CTGGATGGCC 
CCCGAGGTGG TCATGTGTGA GACCATGAAA GACACGCCCT ACGACTACAA AGCCGACATC 
TGGTCCCTGG GCATCACGCT GATTGAGATG GCCCAGATCG AGCCGCCACA CCACGAGCTC 
AACCCCATGC GGGTCCTGCT AAAGATCGCC AAGTCGGACC CTCCCACGCT GCTCACGCCC 
TCTAAGTGGT CTGTAGAGTT CCGTGACTTC CTGAAGATAG CCCTGGATAA GAACCCAGAA 
ACCCGACCCA GTGCCGCGCA GCTGCTGGAG CATCCCTTCG TCAGCAGCAT CACCAGTAAC 
AAGGCTCTGC GGGAGCTGGT GGCTGAGGCC AAGGCCGAGG TGATGGAAGA GATCGAAGAC 
GGCCGGGATG AGGGGGAAGA GGAGGACGCC GTGGATGCCG CCTCCACCCT GGAGAACCAT 
ACTCAGAACT CCTCTGAGGT GAGTCCGCCA AGCCTCAATG CTGACAAGCC TCTCGAGGAG 
TCACCTTCCA CCCCGCTGGC ACCCAGCCAG TCTCAGGACA GTGTGAATGA GCCCTGCAGC 
CAGCCCTCTG GGGACAGATC CCTCCAAACC ACCAGTCCCC CAGTCGTGGC CCCTGGAAAT 
GAGAACGGCC TGGCAGTGCC TGTGCCCCTG CGGAAGTCCC GACCCGTGTC AATGGATGCC 
AGAATTCAGG TAGCCCAGGA GAAGCAAGTT GCTGAGCAGG GTGGGGACCT CAGCCCAGCA 
GCCAACAGAT CTCAAAAGGC CAGCCAGAGC CGGCCCAACA GCAGCGCCCT GGAGACCTTG 
GGTGGGGAGA AGCTGGCCAA TGGCAGCCTG GAGCCACCTG CCCAGGCAGC TCCAGGGCCT 
TCCAAGAGGG ACTCGGACTG CAGCAGCCTC TGCACCTCTG AGAGCATGGA CTATGGTACC 
AATCTCTCCA CTGACCTGTC GCTGAACAAA GAGATGGGCT CTCTGTCCAT CAAGGACCCG 
AAACTGTACA AAAAAACCCT CAAGCGGACA CGCAAATTTG TGGTGGATGG TGTGGAGGTG 
AGCATCACCA CCTCCAAGAT CATCAGCGAA GATGAGAAGA AGGATGAGGA GATGAGATTT 
CTCAGGCGCC AGGAACTCCG AGAGCTTCGG CTGCTCCAGA AAGAAGAGCA TCGGAACCAG 
ACCCAGCTGA GTAACAAGCA TGAGCTGCAG CTGGAGCAAA TGCATAAACG TTTTGAACAG 
GAAATCAACG CCAAGAAGAA GTTCTTTGAC ACGGAATTAG AGAACCTGGA GCGTCAGCAA 
AAGCAGCAAG TGGAGAAGAT GGAGCAAGAC CATGCCGTGC GCCGCCGGGA GGAGGCCAGG 
CGGATCCGCC TGGAGCAGGA TCGGGACTAC ACCAGGTTCC AAGAGCAGCT CAAACTGATG 
AAGAAAGAGG TGAAGAACGA GGTGGAGAAG CTCCCCCGAC AGCAGCGGAA GGAAAGCATG 
AAGCAGAAGA TGGAGGAGCA CACGCAGAAA AAGCAGCTTC TTGACCGGGA CTTTGTAGCC 
AAGCAGAAGG AGGACCTGGA GCTGGCCATG AAGAGGCTCA CCACCGACAA CAGGCGGGAG 
ATCTGTGACA AGGAGCGCGA GTGCCTCATG AAGAAGCAGG AGCTCCTTCG AGACCGGGAA 
GCAGCCCTGT GGGAGATGGA AGAGCACCAG CTGCAGGAGA GGCACCAGCT GGTGAAGCAG 
CAGCTCAAAG ACCAGTACTT CCTCCAGCGG CACGAGCTGC TGCGCAAGCA TGAGAAGGAG 
CGGGAGCAGA TGCAGCGCTA CAACCAGCGC ATGATAGAGC AGCTGAAGGT GCGGCAGCAA 
CAGGAAAAGG CGCGGCTGCC CAAGATCCAG AGGAGTGAGG GCAAGACGCG CATGGCCATG 
TACAAGAAGA GCCTCCACAT CAACGGCGGG GGCAGCGCAG CTGAGCAGCG TGAGAAGATC 
AAGCAGTTCT CCCAGCAGGA GGAGAAGAGG CAGAAGTCGG AGCGGCTGCA GCAACAGCAG 
AAACACGAGA ACCAGATGCG GGACATGCTG GCGCAGTGTG AGAGCAACAT GAGCGAGCTG 
CAGCAGCTGC AGAATGAAAA GTGCCACCTC CTGGTAGAGC ACGAAACCCA GAAACTGAAG 
GCCCTGGATG AGAGCCATAA CCAGAACCTG AAGGAATGGC GGGACAAGCT TCGGCCGCGC 
AAGAAGGCTC TGGAAGAGGA TCTGAACCAG AAGAAGCGGG AGCAGGAGAT GTTCTTCAAG 
CTGAGCGAGG AGGCGGAGTG CCCAAACCCC TCCACCCCAA GCAAGGCCGC CAAGTTCTTC 
CCCTACAGTT CTGCGGATGC TTCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005981.3
CDS	183..3089
Translation	MAFANFRRILRLSTFEKRKSREYEHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVMEEIEDGRDEGEEEDAVDAASTLENHTQNSSEVSPPSLNADKPLEESPSTPLAPSQSQDSVNEPCSQPSGDRSLQTTSPPVVAPGNENGLAVPVPLRKSRPVSMDARIQVAQEKQVAEQGGDLSPAANRSQKASQSRPNSSALETLGGEKLANGSLEPPAQAAPGPSKRDSDCSSLCTSESMDYGTNLSTDLSLNKEMGSLSIKDPKLYKKTLKRTRKFVVDGVEVSITTSKIISEDEKKDEEMRFLRRQELRELRLLQKEEHRNQTQLSNKHELQLEQMHKRFEQEINAKKKFFDTELENLERQQKQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQEQLKLMKKEVKNEVEKLPRQQRKESMKQKMEEHTQKKQLLDRDFVAKQKEDLELAMKRLTTDNRREICDKERECLMKKQELLRDREAALWEMEEHQLQERHQLVKQQLKDQYFLQRHELLRKHEKEREQMQRYNQRMIEQLKVRQQQEKARLPKIQRSEGKTRMAMYKKSLHINGGGSAAEQREKIKQFSQQEEKRQKSERLQQQQKHENQMRDMLAQCESNMSELQQLQNEKCHLLVEHETQKLKALDESHNQNLKEWRDKLRPRKKALEEDLNQKKREQEMFFKLSEEAECPNPSTPSKAAKFFPYSSADAS

Target ORF information:

RefSeq Version	NM_005990.4
Organism	Homo sapiens(human)
Definition	Homo sapiens serine/threonine kinase 10 (STK10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005990.4

ORF Insert Sequence:

ATGGCTTTTG CCAATTTCCG CCGCATCCTG CGCCTGTCTA CCTTCGAGAA GAGAAAGTCC 
CGCGAATATG AGCACGTCCG CCGCGACCTG GACCCCAACG AGGTGTGGGA GATCGTGGGC 
GAGCTGGGCG ACGGCGCCTT CGGCAAGGTT TACAAGGCCA AGAATAAGGA GACGGGTGCT 
TTGGCTGCGG CCAAAGTCAT TGAAACCAAG AGTGAGGAGG AGCTGGAGGA CTACATCGTG 
GAGATTGAGA TCCTGGCCAC CTGCGACCAC CCCTACATTG TGAAGCTCCT GGGAGCCTAC 
TATCACGACG GGAAGCTGTG GATCATGATT GAGTTCTGTC CAGGGGGAGC CGTGGACGCC 
ATCATGCTGG AGCTGGACAG AGGCCTCACG GAGCCCCAGA TACAGGTGGT TTGCCGCCAG 
ATGCTAGAAG CCCTCAACTT CCTGCACAGC AAGAGGATCA TCCACCGAGA TCTGAAAGCT 
GGCAACGTGC TGATGACCCT CGAGGGAGAC ATCAGGCTGG CTGACTTTGG TGTGTCTGCC 
AAGAATCTGA AGACTCTACA GAAACGAGAT TCCTTCATCG GCACGCCTTA CTGGATGGCC 
CCCGAGGTGG TCATGTGTGA GACCATGAAA GACACGCCCT ACGACTACAA AGCCGACATC 
TGGTCCCTGG GCATCACGCT GATTGAGATG GCCCAGATCG AGCCGCCACA CCACGAGCTC 
AACCCCATGC GGGTCCTGCT AAAGATCGCC AAGTCGGACC CTCCCACGCT GCTCACGCCC 
TCTAAGTGGT CTGTAGAGTT CCGTGACTTC CTGAAGATAG CCCTGGATAA GAACCCAGAA 
ACCCGACCCA GTGCCGCGCA GCTGCTGGAG CATCCCTTCG TCAGCAGCAT CACCAGTAAC 
AAGGCTCTGC GGGAGCTGGT GGCTGAGGCC AAGGCCGAGG TGATGGAAGA GATCGAAGAC 
GGCCGGGATG AGGGGGAAGA GGAGGACGCC GTGGATGCCG CCTCCACCCT GGAGAACCAT 
ACTCAGAACT CCTCTGAGGT GAGTCCGCCA AGCCTCAATG CTGACAAGCC TCTCGAGGAG 
TCACCTTCCA CCCCGCTGGC ACCCAGCCAG TCTCAGGACA GTGTGAATGA GCCCTGCAGC 
CAGCCCTCTG GGGACAGATC CCTCCAAACC ACCAGTCCCC CAGTCGTGGC CCCTGGAAAT 
GAGAACGGCC TGGCAGTGCC TGTGCCCCTG CGGAAGTCCC GACCCGTGTC AATGGATGCC 
AGAATTCAGG TAGCCCAGGA GAAGCAAGTT GCTGAGCAGG GTGGGGACCT CAGCCCAGCA 
GCCAACAGAT CTCAAAAGGC CAGCCAGAGC CGGCCCAACA GCAGCGCCCT GGAGACCTTG 
GGTGGGGAGA AGCTGGCCAA TGGCAGCCTG GAGCCACCTG CCCAGGCAGC TCCAGGGCCT 
TCCAAGAGGG ACTCGGACTG CAGCAGCCTC TGCACCTCTG AGAGCATGGA CTATGGTACC 
AATCTCTCCA CTGACCTGTC GCTGAACAAA GAGATGGGCT CTCTGTCCAT CAAGGACCCG 
AAACTGTACA AAAAAACCCT CAAGCGGACA CGCAAATTTG TGGTGGATGG TGTGGAGGTG 
AGCATCACCA CCTCCAAGAT CATCAGCGAA GATGAGAAGA AGGATGAGGA GATGAGATTT 
CTCAGGCGCC AGGAACTCCG AGAGCTTCGG CTGCTCCAGA AAGAAGAGCA TCGGAACCAG 
ACCCAGCTGA GTAACAAGCA TGAGCTGCAG CTGGAGCAAA TGCATAAACG TTTTGAACAG 
GAAATCAACG CCAAGAAGAA GTTCTTTGAC ACGGAATTAG AGAACCTGGA GCGTCAGCAA 
AAGCAGCAAG TGGAGAAGAT GGAGCAAGAC CATGCCGTGC GCCGCCGGGA GGAGGCCAGG 
CGGATCCGCC TGGAGCAGGA TCGGGACTAC ACCAGGTTCC AAGAGCAGCT CAAACTGATG 
AAGAAAGAGG TGAAGAACGA GGTGGAGAAG CTCCCCCGAC AGCAGCGGAA GGAAAGCATG 
AAGCAGAAGA TGGAGGAGCA CACGCAGAAA AAGCAGCTTC TTGACCGGGA CTTTGTAGCC 
AAGCAGAAGG AGGACCTGGA GCTGGCCATG AAGAGGCTCA CCACCGACAA CAGGCGGGAG 
ATCTGTGACA AGGAGCGCGA GTGCCTCATG AAGAAGCAGG AGCTCCTTCG AGACCGGGAA 
GCAGCCCTGT GGGAGATGGA AGAGCACCAG CTGCAGGAGA GGCACCAGCT GGTGAAGCAG 
CAGCTCAAAG ACCAGTACTT CCTCCAGCGG CACGAGCTGC TGCGCAAGCA TGAGAAGGAG 
CGGGAGCAGA TGCAGCGCTA CAACCAGCGC ATGATAGAGC AGCTGAAGGT GCGGCAGCAA 
CAGGAAAAGG CGCGGCTGCC CAAGATCCAG AGGAGTGAGG GCAAGACGCG CATGGCCATG 
TACAAGAAGA GCCTCCACAT CAACGGCGGG GGCAGCGCAG CTGAGCAGCG TGAGAAGATC 
AAGCAGTTCT CCCAGCAGGA GGAGAAGAGG CAGAAGTCGG AGCGGCTGCA GCAACAGCAG 
AAACACGAGA ACCAGATGCG GGACATGCTG GCGCAGTGTG AGAGCAACAT GAGCGAGCTG 
CAGCAGCTGC AGAATGAAAA GTGCCACCTC CTGGTAGAGC ACGAAACCCA GAAACTGAAG 
GCCCTGGATG AGAGCCATAA CCAGAACCTG AAGGAATGGC GGGACAAGCT TCGGCCGCGC 
AAGAAGGCTC TGGAAGAGGA TCTGAACCAG AAGAAGCGGG AGCAGGAGAT GTTCTTCAAG 
CTGAGCGAGG AGGCGGAGTG CCCAAACCCC TCCACCCCAA GCAAGGCCGC CAAGTTCTTC 
CCCTACAGTT CTGCGGATGC TTCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

STK10 ( XM_017009788.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016865277.1 Homo sapiens serine/threonine kinase 10 (STK10), transcript variant X1, mRNA.

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CloneID	OHu96029
Clone ID Related Accession (Same CDS sequence)	XM_017009788.1
Accession Version	XM_017009788.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2583bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	serine/threonine-protein kinase 10 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATTGAGT TCTGTCCAGG GGGAGCCGTG GACGCCATCA TGCTGGAGCT GGACAGAGGC 
CTCACGGAGC CCCAGATACA GGTGGTTTGC CGCCAGATGC TAGAAGCCCT CAACTTCCTG 
CACAGCAAGA GGATCATCCA CCGAGATCTG AAAGCTGGCA ACGTGCTGAT GACCCTCGAG 
GGAGACATCA GGCTGGCTGA CTTTGGTGTG TCTGCCAAGA ATCTGAAGAC TCTACAGAAA 
CGAGATTCCT TCATCGGCAC GCCTTACTGG ATGGCCCCCG AGGTGGTCAT GTGTGAGACC 
ATGAAAGACA CGCCCTACGA CTACAAAGCC GACATCTGGT CCCTGGGCAT CACGCTGATT 
GAGATGGCCC AGATCGAGCC GCCACACCAC GAGCTCAACC CCATGCGGGT CCTGCTAAAG 
ATCGCCAAGT CGGACCCTCC CACGCTGCTC ACGCCCTCTA AGTGGTCTGT AGAGTTCCGT 
GACTTCCTGA AGATAGCCCT GGATAAGAAC CCAGAAACCC GACCCAGTGC CGCGCAGCTG 
CTGGAGCATC CCTTCGTCAG CAGCATCACC AGTAACAAGG CTCTGCGGGA GCTGGTGGCT 
GAGGCCAAGG CCGAGGTGAT GGAAGAGATC GAAGACGGCC GGGATGAGGG GGAAGAGGAG 
GACGCCGTGG ATGCCGCCTC CACCCTGGAG AACCATACTC AGAACTCCTC TGAGGTGAGT 
CCGCCAAGCC TCAATGCTGA CAAGCCTCTC GAGGAGTCAC CTTCCACCCC GCTGGCACCC 
AGCCAGTCTC AGGACAGTGT GAATGAGCCC TGCAGCCAGC CCTCTGGGGA CAGATCCCTC 
CAAACCACCA GTCCCCCAGT CGTGGCCCCT GGAAATGAGA ACGGCCTGGC AGTGCCTGTG 
CCCCTGCGGA AGTCCCGACC CGTGTCAATG GATGCCAGAA TTCAGGTAGC CCAGGAGAAG 
CAAGTTGCTG AGCAGGGTGG GGACCTCAGC CCAGCAGCCA ACAGATCTCA AAAGGCCAGC 
CAGAGCCGGC CCAACAGCAG CGCCCTGGAG ACCTTGGGTG GGGAGAAGCT GGCCAATGGC 
AGCCTGGAGC CACCTGCCCA GGCAGCTCCA GGGCCTTCCA AGAGGGACTC GGACTGCAGC 
AGCCTCTGCA CCTCTGAGAG CATGGACTAT GGTACCAATC TCTCCACTGA CCTGTCGCTG 
AACAAAGAGA TGGGCTCTCT GTCCATCAAG GACCCGAAAC TGTACAAAAA AACCCTCAAG 
CGGACACGCA AATTTGTGGT GGATGGTGTG GAGGTGAGCA TCACCACCTC CAAGATCATC 
AGCGAAGATG AGAAGAAGGA TGAGGAGATG AGATTTCTCA GGCGCCAGGA ACTCCGAGAG 
CTTCGGCTGC TCCAGAAAGA AGAGCATCGG AACCAGACCC AGCTGAGTAA CAAGCATGAG 
CTGCAGCTGG AGCAAATGCA TAAACGTTTT GAACAGGAAA TCAACGCCAA GAAGAAGTTC 
TTTGACACGG AATTAGAGAA CCTGGAGCGT CAGCAAAAGC AGCAAGTGGA GAAGATGGAG 
CAAGACCATG CCGTGCGCCG CCGGGAGGAG GCCAGGCGGA TCCGCCTGGA GCAGGATCGG 
GACTACACCA GGTTCCAAGA GCAGCTCAAA CTGATGAAGA AAGAGGTGAA GAACGAGGTG 
GAGAAGCTCC CCCGACAGCA GCGGAAGGAA AGCATGAAGC AGAAGATGGA GGAGCACACG 
CAGAAAAAGC AGCTTCTTGA CCGGGACTTT GTAGCCAAGC AGAAGGAGGA CCTGGAGCTG 
GCCATGAAGA GGCTCACCAC CGACAACAGG CGGGAGATCT GTGACAAGGA GCGCGAGTGC 
CTCATGAAGA AGCAGGAGCT CCTTCGAGAC CGGGAAGCAG CCCTGTGGGA GATGGAAGAG 
CACCAGCTGC AGGAGAGGCA CCAGCTGGTG AAGCAGCAGC TCAAAGACCA GTACTTCCTC 
CAGCGGCACG AGCTGCTGCG CAAGCATGAG AAGGAGCGGG AGCAGATGCA GCGCTACAAC 
CAGCGCATGA TAGAGCAGCT GAAGGTGCGG CAGCAACAGG AAAAGGCGCG GCTGCCCAAG 
ATCCAGAGGA GTGAGGGCAA GACGCGCATG GCCATGTACA AGAAGAGCCT CCACATCAAC 
GGCGGGGGCA GCGCAGCTGA GCAGCGTGAG AAGATCAAGC AGTTCTCCCA GCAGGAGGAG 
AAGAGGCAGA AGTCGGAGCG GCTGCAGCAA CAGCAGAAAC ACGAGAACCA GATGCGGGAC 
ATGCTGGCGC AGTGTGAGAG CAACATGAGC GAGCTGCAGC AGCTGCAGAA TGAAAAGTGC 
CACCTCCTGG TAGAGCACGA AACCCAGAAA CTGAAGGCCC TGGATGAGAG CCATAACCAG 
AACCTGAAGG AATGGCGGGA CAAGCTTCGG CCGCGCAAGA AGGCTCTGGA AGAGGATCTG 
AACCAGAAGA AGCGGGAGCA GGAGATGTTC TTCAAGCTGA GCGAGGAGGC GGAGTGCCCA 
AACCCCTCCA CCCCAAGCAA GGCCGCCAAG TTCTTCCCCT ACAGTTCTGC GGATGCTTCT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016865277.1
CDS	179..2761
Translation	MIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVMEEIEDGRDEGEEEDAVDAASTLENHTQNSSEVSPPSLNADKPLEESPSTPLAPSQSQDSVNEPCSQPSGDRSLQTTSPPVVAPGNENGLAVPVPLRKSRPVSMDARIQVAQEKQVAEQGGDLSPAANRSQKASQSRPNSSALETLGGEKLANGSLEPPAQAAPGPSKRDSDCSSLCTSESMDYGTNLSTDLSLNKEMGSLSIKDPKLYKKTLKRTRKFVVDGVEVSITTSKIISEDEKKDEEMRFLRRQELRELRLLQKEEHRNQTQLSNKHELQLEQMHKRFEQEINAKKKFFDTELENLERQQKQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQEQLKLMKKEVKNEVEKLPRQQRKESMKQKMEEHTQKKQLLDRDFVAKQKEDLELAMKRLTTDNRREICDKERECLMKKQELLRDREAALWEMEEHQLQERHQLVKQQLKDQYFLQRHELLRKHEKEREQMQRYNQRMIEQLKVRQQQEKARLPKIQRSEGKTRMAMYKKSLHINGGGSAAEQREKIKQFSQQEEKRQKSERLQQQQKHENQMRDMLAQCESNMSELQQLQNEKCHLLVEHETQKLKALDESHNQNLKEWRDKLRPRKKALEEDLNQKKREQEMFFKLSEEAECPNPSTPSKAAKFFPYSSADAS

Target ORF information:

RefSeq Version	XM_017009788.1
Organism	Homo sapiens(human)
Definition	Homo sapiens serine/threonine kinase 10 (STK10), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017009788.1

ORF Insert Sequence:

ATGATTGAGT TCTGTCCAGG GGGAGCCGTG GACGCCATCA TGCTGGAGCT GGACAGAGGC 
CTCACGGAGC CCCAGATACA GGTGGTTTGC CGCCAGATGC TAGAAGCCCT CAACTTCCTG 
CACAGCAAGA GGATCATCCA CCGAGATCTG AAAGCTGGCA ACGTGCTGAT GACCCTCGAG 
GGAGACATCA GGCTGGCTGA CTTTGGTGTG TCTGCCAAGA ATCTGAAGAC TCTACAGAAA 
CGAGATTCCT TCATCGGCAC GCCTTACTGG ATGGCCCCCG AGGTGGTCAT GTGTGAGACC 
ATGAAAGACA CGCCCTACGA CTACAAAGCC GACATCTGGT CCCTGGGCAT CACGCTGATT 
GAGATGGCCC AGATCGAGCC GCCACACCAC GAGCTCAACC CCATGCGGGT CCTGCTAAAG 
ATCGCCAAGT CGGACCCTCC CACGCTGCTC ACGCCCTCTA AGTGGTCTGT AGAGTTCCGT 
GACTTCCTGA AGATAGCCCT GGATAAGAAC CCAGAAACCC GACCCAGTGC CGCGCAGCTG 
CTGGAGCATC CCTTCGTCAG CAGCATCACC AGTAACAAGG CTCTGCGGGA GCTGGTGGCT 
GAGGCCAAGG CCGAGGTGAT GGAAGAGATC GAAGACGGCC GGGATGAGGG GGAAGAGGAG 
GACGCCGTGG ATGCCGCCTC CACCCTGGAG AACCATACTC AGAACTCCTC TGAGGTGAGT 
CCGCCAAGCC TCAATGCTGA CAAGCCTCTC GAGGAGTCAC CTTCCACCCC GCTGGCACCC 
AGCCAGTCTC AGGACAGTGT GAATGAGCCC TGCAGCCAGC CCTCTGGGGA CAGATCCCTC 
CAAACCACCA GTCCCCCAGT CGTGGCCCCT GGAAATGAGA ACGGCCTGGC AGTGCCTGTG 
CCCCTGCGGA AGTCCCGACC CGTGTCAATG GATGCCAGAA TTCAGGTAGC CCAGGAGAAG 
CAAGTTGCTG AGCAGGGTGG GGACCTCAGC CCAGCAGCCA ACAGATCTCA AAAGGCCAGC 
CAGAGCCGGC CCAACAGCAG CGCCCTGGAG ACCTTGGGTG GGGAGAAGCT GGCCAATGGC 
AGCCTGGAGC CACCTGCCCA GGCAGCTCCA GGGCCTTCCA AGAGGGACTC GGACTGCAGC 
AGCCTCTGCA CCTCTGAGAG CATGGACTAT GGTACCAATC TCTCCACTGA CCTGTCGCTG 
AACAAAGAGA TGGGCTCTCT GTCCATCAAG GACCCGAAAC TGTACAAAAA AACCCTCAAG 
CGGACACGCA AATTTGTGGT GGATGGTGTG GAGGTGAGCA TCACCACCTC CAAGATCATC 
AGCGAAGATG AGAAGAAGGA TGAGGAGATG AGATTTCTCA GGCGCCAGGA ACTCCGAGAG 
CTTCGGCTGC TCCAGAAAGA AGAGCATCGG AACCAGACCC AGCTGAGTAA CAAGCATGAG 
CTGCAGCTGG AGCAAATGCA TAAACGTTTT GAACAGGAAA TCAACGCCAA GAAGAAGTTC 
TTTGACACGG AATTAGAGAA CCTGGAGCGT CAGCAAAAGC AGCAAGTGGA GAAGATGGAG 
CAAGACCATG CCGTGCGCCG CCGGGAGGAG GCCAGGCGGA TCCGCCTGGA GCAGGATCGG 
GACTACACCA GGTTCCAAGA GCAGCTCAAA CTGATGAAGA AAGAGGTGAA GAACGAGGTG 
GAGAAGCTCC CCCGACAGCA GCGGAAGGAA AGCATGAAGC AGAAGATGGA GGAGCACACG 
CAGAAAAAGC AGCTTCTTGA CCGGGACTTT GTAGCCAAGC AGAAGGAGGA CCTGGAGCTG 
GCCATGAAGA GGCTCACCAC CGACAACAGG CGGGAGATCT GTGACAAGGA GCGCGAGTGC 
CTCATGAAGA AGCAGGAGCT CCTTCGAGAC CGGGAAGCAG CCCTGTGGGA GATGGAAGAG 
CACCAGCTGC AGGAGAGGCA CCAGCTGGTG AAGCAGCAGC TCAAAGACCA GTACTTCCTC 
CAGCGGCACG AGCTGCTGCG CAAGCATGAG AAGGAGCGGG AGCAGATGCA GCGCTACAAC 
CAGCGCATGA TAGAGCAGCT GAAGGTGCGG CAGCAACAGG AAAAGGCGCG GCTGCCCAAG 
ATCCAGAGGA GTGAGGGCAA GACGCGCATG GCCATGTACA AGAAGAGCCT CCACATCAAC 
GGCGGGGGCA GCGCAGCTGA GCAGCGTGAG AAGATCAAGC AGTTCTCCCA GCAGGAGGAG 
AAGAGGCAGA AGTCGGAGCG GCTGCAGCAA CAGCAGAAAC ACGAGAACCA GATGCGGGAC 
ATGCTGGCGC AGTGTGAGAG CAACATGAGC GAGCTGCAGC AGCTGCAGAA TGAAAAGTGC 
CACCTCCTGG TAGAGCACGA AACCCAGAAA CTGAAGGCCC TGGATGAGAG CCATAACCAG 
AACCTGAAGG AATGGCGGGA CAAGCTTCGG CCGCGCAAGA AGGCTCTGGA AGAGGATCTG 
AACCAGAAGA AGCGGGAGCA GGAGATGTTC TTCAAGCTGA GCGAGGAGGC GGAGTGCCCA 
AACCCCTCCA CCCCAAGCAA GGCCGCCAAG TTCTTCCCCT ACAGTTCTGC GGATGCTTCT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ezrin activation by LOK phosphorylation involves a PIP
eLife6(2017 04)
Pelaseyed T,Viswanatha R,Sauvanet C,Filter JJ,Goldberg ML,Bretscher A

Altered mitochondrial expression genes in patients receiving right ventricular apical pacing.
Experimental and molecular pathology100(3)469-75(2016 06)
Xu H,Gao J,Wang F

STK10 missense mutations associated with anti-apoptotic function.
Oncology reports30(4)1542-8(2013 Oct)
Fukumura K,Yamashita Y,Kawazu M,Sai E,Fujiwara S,Nakamura N,Takeuchi K,Ando M,Miyazono K,Ueno T,Ozawa K,Mano H

Genome-wide meta-analysis identifies new susceptibility loci for migraine.
Nature genetics45(8)912-917(2013 Aug)
Anttila V,Winsvold BS,Gormley P,Kurth T,Bettella F,McMahon G,Kallela M,Malik R,de Vries B,Terwindt G,Medland SE,Todt U,McArdle WL,Quaye L,Koiranen M,Ikram MA,Lehtim?ki T,Stam AH,Ligthart L,Wedenoja J,Dunham I,Neale BM,Palta P,Hamalainen E,Sch?rks M,Rose LM,Buring JE,Ridker PM,Steinberg S,Stefansson H,Jakobsson F,Lawlor DA,Evans DM,Ring SM,F?rkkil? M,Artto V,Kaunisto MA,Freilinger T,Schoenen J,Frants RR,Pelzer N,Weller CM,Zielman R,Heath AC,Madden PAF,Montgomery GW,Martin NG,Borck G,G?bel H,Heinze A,Heinze-Kuhn K,Williams FMK,Hartikainen AL,Pouta A,van den Ende J,Uitterlinden AG,Hofman A,Amin N,Hottenga JJ,Vink JM,Heikkil? K,Alexander M,Muller-Myhsok B,Schreiber S,Meitinger T,Wichmann HE,Aromaa A,Eriksson JG,Traynor B,Trabzuni D,,,Rossin E,Lage K,Jacobs SBR,Gibbs JR,Birney E,Kaprio J,Penninx BW,Boomsma DI,van Duijn C,Raitakari O,Jarvelin MR,Zwart JA,Cherkas L,Strachan DP,Kubisch C,Ferrari MD,van den Maagdenberg AMJM,Dichgans M,Wessman M,Smith GD,Stefansson K,Daly MJ,Nyholt DR,Chasman D,Palotie A

Local phosphocycling mediated by LOK/SLK restricts ezrin function to the apical aspect of epithelial cells.
The Journal of cell biology199(6)969-84(2012 Dec)
Viswanatha R,Ohouo PY,Smolka MB,Bretscher A

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STK10 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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