ELOVL4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ELOVL4
Entrez Gene ID	6785
Full Name	ELOVL fatty acid elongase 4
Synonyms	ADMD,CT118,ISQMR,SCA34,STGD2,STGD3
General protein information	Preferred Names ELOVL fatty acid elongase 4 Names elongation of very long chain fatty acids protein 4 3-keto acyl-CoA synthase ELOVL4 ELOVL FA elongase 4 cancer/testis antigen 118 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4 very long chain 3-ketoacyl-CoA synthase 4 very long chain 3-oxoacyl-CoA synthase 4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6q14.1
Summary	This gene encodes a membrane-bound protein which is a member of the ELO family, proteins which participate in the biosynthesis of fatty acids. Consistent with the expression of the encoded protein in photoreceptor cells of the retina, mutations and small deletions in this gene are associated with Stargardt-like macular dystrophy (STGD3) and autosomal dominant Stargardt-like macular dystrophy (ADMD), also referred to as autosomal dominant atrophic macular degeneration. [provided by RefSeq, Jul 2008].
Disorder MIM:	605512
Disorder Html:	Stargardt disease 3, 600110 (3); Ichthyosis, spastic quadriplegia, and mental retardation, 614457 (3); Spinocerebellar ataxia 34, 133190 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_022726.4	NP_073563.1	elongation of very long chain fatty acids protein 4
NM_022726.3	NP_073563.1	elongation of very long chain fatty acids protein 4

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Elovl4	NP_001178725.1
Mus musculus (house mouse)	Elovl4	NP_683743.2
Gallus gallus (chicken)	ELOVL4	NP_001184238.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008780	XP_314908.3
Homo sapiens (human)	ELOVL4	NP_073563.1
Pan troglodytes (chimpanzee)	ELOVL4	XP_518601.2
	ELOVL4	NP_001035509.1
Canis lupus familiaris (dog)	ELOVL4	XP_539015.1
Danio rerio (zebrafish)	LOC100332451	XP_002664825.2
Bos taurus (cattle)	ELOVL4	NP_001092520.1
Danio rerio (zebrafish)	elovl4a	NP_957090.1
Danio rerio (zebrafish)	elovl4b	NP_956266.1
Drosophila melanogaster (fruit fly)	CG5278	NP_651063.1
Xenopus tropicalis (tropical clawed frog)	elovl4	XP_002936253.1

Gene Ontology
Bibliography

Related articles in PubMed

Analysis of ELOVL4 and PRPH2 genes in Turkish Stargardt disease patients.
Bardak H, Gunay M, Er?al?k Y, Bardak Y, Ozbas H, Bagci O, Ayata A, S?nmez M, Alag?z C
Genetics and molecular research : GMR15(4)(2016 Oct)

Swiss Family with Dominant Stargardt Disease Caused by a Recurrent Mutation in the ELOVL4 Gene.
Tran HV, Moret E, Vaclavik V, Marcelli F, Abitbol MM, Munier FL, Schorderet DF
Klinische Monatsblatter fur Augenheilkunde233(4)475-7(2016 Apr)

Different Mutations in ELOVL4 Affect Very Long Chain Fatty Acid Biosynthesis to Cause Variable Neurological Disorders in Humans.
Agbaga MP
Advances in experimental medicine and biology854129-35(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In the control group, four different genetic variations were detected in ELOVL4, and five in PRPH2. STGD patients of different ethnicities may carry distinct ELOVL4 and PRPH2 sequence variants. We believe that the genetic variations identified in this study may be related to STGD etiopathogenesis.
Title: Analysis of ELOVL4 and PRPH2 genes in Turkish Stargardt disease patients.

Swiss Family with Dominant Stargardt Disease Caused by a Recurrent Mutation in the ELOVL4 Gene
Title: Swiss Family with Dominant Stargardt Disease Caused by a Recurrent Mutation in the ELOVL4 Gene.

different mutations in ELOVL4 can cause variable phenotypic neurological disorders (Review)
Title: Different Mutations in ELOVL4 Affect Very Long Chain Fatty Acid Biosynthesis to Cause Variable Neurological Disorders in Humans.

Both ELOVL4- and PROM1-related maculopathies are characterized by progressive photoreceptor atrophy and central vision loss. Using advanced diagnostic imaging, early disease changes and disease progression can be characterized.
Title: INSIGHTS INTO AUTOSOMAL DOMINANT STARGARDT-LIKE MACULAR DYSTROPHY THROUGH MULTIMODALITY DIAGNOSTIC IMAGING.

Spinocerebellar ataxia was associated with a novel mutation in ELOVL4 in a large family pedigree.
Title: A Novel Mutation in ELOVL4 Leading to Spinocerebellar Ataxia (SCA) With the Hot Cross Bun Sign but Lacking Erythrokeratodermia: A Broadened Spectrum of SCA34.

The following ELOVL4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ELOVL4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu27833	NM_022726.4 Latest version!	Homo sapiens ELOVL fatty acid elongase 4 (ELOVL4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
View Old Accession Versions >>
OHu27833	NM_022726.3	Homo sapiens ELOVL fatty acid elongase 4 (ELOVL4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ELOVL4 ( NM_022726.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_073563.1 Homo sapiens ELOVL fatty acid elongase 4 (ELOVL4), mRNA.

Price & Availability↑

CloneID	OHu27833
Clone ID Related Accession (Same CDS sequence)	NM_022726.4 , NM_022726.3
Accession Version	NM_022726.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 945bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	elongation of very long chain fatty acids protein 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA122864.1 and AY037298.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_022726.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.277774.1, SRR1660803.82741.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000369816.5/ ENSP00000358831.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGGCTCC TGGACTCGGA GCCGGGTAGT GTCCTAAACG TAGTGTCCAC GGCACTCAAC 
GACACGGTAG AGTTCTACCG CTGGACCTGG TCCATCGCAG ATAAGCGTGT GGAAAATTGG 
CCTCTGATGC AGTCTCCTTG GCCTACACTA AGTATAAGCA CTCTTTATCT CCTGTTTGTG 
TGGCTGGGTC CAAAATGGAT GAAGGACCGA GAACCTTTTC AGATGCGTCT AGTGCTCATT 
ATCTATAATT TTGGGATGGT TTTGCTTAAC CTCTTTATCT TCAGAGAGTT ATTCATGGGA 
TCATATAATG CGGGATATAG CTATATTTGC CAGAGTGTGG ATTATTCTAA TAATGTTCAT 
GAAGTCAGGA TAGCTGCTGC TCTGTGGTGG TACTTTGTAT CTAAAGGAGT TGAGTATTTG 
GACACAGTGT TTTTTATTCT GAGAAAGAAA AACAACCAAG TTTCTTTCCT TCATGTGTAT 
CATCACTGTA CGATGTTTAC CTTGTGGTGG ATTGGAATTA AGTGGGTTGC AGGAGGACAA 
GCATTTTTTG GAGCCCAGTT GAATTCCTTT ATCCATGTGA TTATGTACTC ATACTATGGG 
TTAACTGCAT TTGGCCCATG GATTCAGAAA TATCTTTGGT GGAAACGATA CCTGACTATG 
TTGCAACTGA TTCAATTCCA TGTGACCATT GGGCACACGG CACTGTCTCT TTACACTGAC 
TGCCCCTTCC CCAAATGGAT GCACTGGGCT CTAATTGCCT ATGCAATCAG CTTCATATTT 
CTCTTTCTTA ACTTCTACAT TCGGACATAC AAAGAGCCTA AGAAACCAAA AGCTGGAAAA 
ACAGCCATGA ATGGTATTTC AGCAAATGGT GTGAGCAAAT CAGAAAAACA ACTCATGATA 
GAAAATGGAA AAAAGCAGAA AAATGGAAAA GCAAAAGGAG ATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_073563.1
CDS	275..1219
Translation	MGLLDSEPGSVLNVVSTALNDTVEFYRWTWSIADKRVENWPLMQSPWPTLSISTLYLLFVWLGPKWMKDREPFQMRLVLIIYNFGMVLLNLFIFRELFMGSYNAGYSYICQSVDYSNNVHEVRIAAALWWYFVSKGVEYLDTVFFILRKKNNQVSFLHVYHHCTMFTLWWIGIKWVAGGQAFFGAQLNSFIHVIMYSYYGLTAFGPWIQKYLWWKRYLTMLQLIQFHVTIGHTALSLYTDCPFPKWMHWALIAYAISFIFLFLNFYIRTYKEPKKPKAGKTAMNGISANGVSKSEKQLMIENGKKQKNGKAKGD

Target ORF information:

RefSeq Version	NM_022726.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ELOVL fatty acid elongase 4 (ELOVL4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022726.4

ORF Insert Sequence:

ATGGGGCTCC TGGACTCGGA GCCGGGTAGT GTCCTAAACG TAGTGTCCAC GGCACTCAAC 
GACACGGTAG AGTTCTACCG CTGGACCTGG TCCATCGCAG ATAAGCGTGT GGAAAATTGG 
CCTCTGATGC AGTCTCCTTG GCCTACACTA AGTATAAGCA CTCTTTATCT CCTGTTTGTG 
TGGCTGGGTC CAAAATGGAT GAAGGACCGA GAACCTTTTC AGATGCGTCT AGTGCTCATT 
ATCTATAATT TTGGGATGGT TTTGCTTAAC CTCTTTATCT TCAGAGAGTT ATTCATGGGA 
TCATATAATG CGGGATATAG CTATATTTGC CAGAGTGTGG ATTATTCTAA TAATGTTCAT 
GAAGTCAGGA TAGCTGCTGC TCTGTGGTGG TACTTTGTAT CTAAAGGAGT TGAGTATTTG 
GACACAGTGT TTTTTATTCT GAGAAAGAAA AACAACCAAG TTTCTTTCCT TCATGTGTAT 
CATCACTGTA CGATGTTTAC CTTGTGGTGG ATTGGAATTA AGTGGGTTGC AGGAGGACAA 
GCATTTTTTG GAGCCCAGTT GAATTCCTTT ATCCATGTGA TTATGTACTC ATACTATGGG 
TTAACTGCAT TTGGCCCATG GATTCAGAAA TATCTTTGGT GGAAACGATA CCTGACTATG 
TTGCAACTGA TTCAATTCCA TGTGACCATT GGGCACACGG CACTGTCTCT TTACACTGAC 
TGCCCCTTCC CCAAATGGAT GCACTGGGCT CTAATTGCCT ATGCAATCAG CTTCATATTT 
CTCTTTCTTA ACTTCTACAT TCGGACATAC AAAGAGCCTA AGAAACCAAA AGCTGGAAAA 
ACAGCCATGA ATGGTATTTC AGCAAATGGT GTGAGCAAAT CAGAAAAACA ACTCATGATA 
GAAAATGGAA AAAAGCAGAA AAATGGAAAA GCAAAAGGAG ATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ELOVL4 ( NM_022726.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_073563.1 Homo sapiens ELOVL fatty acid elongase 4 (ELOVL4), mRNA.

Price & Availability↑

CloneID	OHu27833
Clone ID Related Accession (Same CDS sequence)	NM_022726.4 , NM_022726.3
Accession Version	NM_022726.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 945bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	elongation of very long chain fatty acids protein 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA122864.1 and AY037298.1. This sequence is a reference standard in the RefSeqGene project. On Mar 7, 2008 this sequence version replaced NM_022726.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY037298.1, SRR1660807.184624.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGCTCC TGGACTCGGA GCCGGGTAGT GTCCTAAACG TAGTGTCCAC GGCACTCAAC 
GACACGGTAG AGTTCTACCG CTGGACCTGG TCCATCGCAG ATAAGCGTGT GGAAAATTGG 
CCTCTGATGC AGTCTCCTTG GCCTACACTA AGTATAAGCA CTCTTTATCT CCTGTTTGTG 
TGGCTGGGTC CAAAATGGAT GAAGGACCGA GAACCTTTTC AGATGCGTCT AGTGCTCATT 
ATCTATAATT TTGGGATGGT TTTGCTTAAC CTCTTTATCT TCAGAGAGTT ATTCATGGGA 
TCATATAATG CGGGATATAG CTATATTTGC CAGAGTGTGG ATTATTCTAA TAATGTTCAT 
GAAGTCAGGA TAGCTGCTGC TCTGTGGTGG TACTTTGTAT CTAAAGGAGT TGAGTATTTG 
GACACAGTGT TTTTTATTCT GAGAAAGAAA AACAACCAAG TTTCTTTCCT TCATGTGTAT 
CATCACTGTA CGATGTTTAC CTTGTGGTGG ATTGGAATTA AGTGGGTTGC AGGAGGACAA 
GCATTTTTTG GAGCCCAGTT GAATTCCTTT ATCCATGTGA TTATGTACTC ATACTATGGG 
TTAACTGCAT TTGGCCCATG GATTCAGAAA TATCTTTGGT GGAAACGATA CCTGACTATG 
TTGCAACTGA TTCAATTCCA TGTGACCATT GGGCACACGG CACTGTCTCT TTACACTGAC 
TGCCCCTTCC CCAAATGGAT GCACTGGGCT CTAATTGCCT ATGCAATCAG CTTCATATTT 
CTCTTTCTTA ACTTCTACAT TCGGACATAC AAAGAGCCTA AGAAACCAAA AGCTGGAAAA 
ACAGCCATGA ATGGTATTTC AGCAAATGGT GTGAGCAAAT CAGAAAAACA ACTCATGATA 
GAAAATGGAA AAAAGCAGAA AAATGGAAAA GCAAAAGGAG ATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_073563.1
CDS	320..1264
Translation	MGLLDSEPGSVLNVVSTALNDTVEFYRWTWSIADKRVENWPLMQSPWPTLSISTLYLLFVWLGPKWMKDREPFQMRLVLIIYNFGMVLLNLFIFRELFMGSYNAGYSYICQSVDYSNNVHEVRIAAALWWYFVSKGVEYLDTVFFILRKKNNQVSFLHVYHHCTMFTLWWIGIKWVAGGQAFFGAQLNSFIHVIMYSYYGLTAFGPWIQKYLWWKRYLTMLQLIQFHVTIGHTALSLYTDCPFPKWMHWALIAYAISFIFLFLNFYIRTYKEPKKPKAGKTAMNGISANGVSKSEKQLMIENGKKQKNGKAKGD

Target ORF information:

RefSeq Version	NM_022726.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ELOVL fatty acid elongase 4 (ELOVL4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022726.3

ORF Insert Sequence:

ATGGGGCTCC TGGACTCGGA GCCGGGTAGT GTCCTAAACG TAGTGTCCAC GGCACTCAAC 
GACACGGTAG AGTTCTACCG CTGGACCTGG TCCATCGCAG ATAAGCGTGT GGAAAATTGG 
CCTCTGATGC AGTCTCCTTG GCCTACACTA AGTATAAGCA CTCTTTATCT CCTGTTTGTG 
TGGCTGGGTC CAAAATGGAT GAAGGACCGA GAACCTTTTC AGATGCGTCT AGTGCTCATT 
ATCTATAATT TTGGGATGGT TTTGCTTAAC CTCTTTATCT TCAGAGAGTT ATTCATGGGA 
TCATATAATG CGGGATATAG CTATATTTGC CAGAGTGTGG ATTATTCTAA TAATGTTCAT 
GAAGTCAGGA TAGCTGCTGC TCTGTGGTGG TACTTTGTAT CTAAAGGAGT TGAGTATTTG 
GACACAGTGT TTTTTATTCT GAGAAAGAAA AACAACCAAG TTTCTTTCCT TCATGTGTAT 
CATCACTGTA CGATGTTTAC CTTGTGGTGG ATTGGAATTA AGTGGGTTGC AGGAGGACAA 
GCATTTTTTG GAGCCCAGTT GAATTCCTTT ATCCATGTGA TTATGTACTC ATACTATGGG 
TTAACTGCAT TTGGCCCATG GATTCAGAAA TATCTTTGGT GGAAACGATA CCTGACTATG 
TTGCAACTGA TTCAATTCCA TGTGACCATT GGGCACACGG CACTGTCTCT TTACACTGAC 
TGCCCCTTCC CCAAATGGAT GCACTGGGCT CTAATTGCCT ATGCAATCAG CTTCATATTT 
CTCTTTCTTA ACTTCTACAT TCGGACATAC AAAGAGCCTA AGAAACCAAA AGCTGGAAAA 
ACAGCCATGA ATGGTATTTC AGCAAATGGT GTGAGCAAAT CAGAAAAACA ACTCATGATA 
GAAAATGGAA AAAAGCAGAA AAATGGAAAA GCAAAAGGAG ATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Analysis of ELOVL4 and PRPH2 genes in Turkish Stargardt disease patients.
Genetics and molecular research : GMR15(4)(2016 Oct)
Bardak H,Gunay M,Er?al?k Y,Bardak Y,Ozbas H,Bagci O,Ayata A,S?nmez M,Alag?z C

Swiss Family with Dominant Stargardt Disease Caused by a Recurrent Mutation in the ELOVL4 Gene.
Klinische Monatsblatter fur Augenheilkunde233(4)475-7(2016 Apr)
Tran HV,Moret E,Vaclavik V,Marcelli F,Abitbol MM,Munier FL,Schorderet DF

Different Mutations in ELOVL4 Affect Very Long Chain Fatty Acid Biosynthesis to Cause Variable Neurological Disorders in Humans.
Advances in experimental medicine and biology854129-35(2016)
Agbaga MP

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ELOVL4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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