SSR1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SSR1
Entrez Gene ID	6745
Full Name	signal sequence receptor subunit 1
Synonyms	TRAPA
General protein information	Preferred Names signal sequence receptor subunit 1 Names translocon-associated protein subunit alpha SSR alpha subunit SSR-alpha TRAP alpha signal sequence receptor subunit alpha signal sequence receptor, alpha translocon-associated protein alpha subunit
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p24.3
Summary	The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein encoded by this gene and a 22-kD glycoprotein. This gene generates several mRNA species as a result of complex alternative polyadenylation. This gene is unusual in that it utilizes arrays of polyA signal sequences that are mostly non-canonical. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014].
Disorder MIM:	600868

mRNA and Protein(s)

mRNA	Protein	Name
NM_003144.4	NP_003135.2	translocon-associated protein subunit alpha isoform 1 precursor
NM_003144.5	NP_003135.2	translocon-associated protein subunit alpha isoform 1 precursor
NM_001292008.2	NP_001278937.1	translocon-associated protein subunit alpha isoform 2 precursor
NM_001292008.1	NP_001278937.1	translocon-associated protein subunit alpha isoform 2 precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	SSR1	NP_001003270.1
Bos taurus (cattle)	SSR1	NP_001095592.1
Rattus norvegicus (Norway rat)	Ssr1	NP_001008891.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001721	XP_321364.3
Xenopus tropicalis (tropical clawed frog)	ssr1	NP_001016912.1
Pan troglodytes (chimpanzee)	SSR1	XP_003311142.1
Gallus gallus (chicken)	SSR1	NP_001006375.1
Drosophila melanogaster (fruit fly)	l(1)G0320	NP_572567.1
Caenorhabditis elegans (roundworm)	trap-1	NP_491076.1
Danio rerio (zebrafish)	ssr1	NP_958484.1
Homo sapiens (human)	SSR1	NP_003135.2
	SSR1	XP_001083953.1
Mus musculus (house mouse)	Ssr1	NP_080241.3

Gene Ontology
Bibliography

Related articles in PubMed

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
, , , , , Mahajan A, Go MJ, Zhang W, Below JE, Gaulton KJ, Ferreira T, Horikoshi M, Johnson AD, Ng MC, Prokopenko I, Saleheen D, Wang X, Zeggini E, Abecasis GR, Adair LS, Almgren P, Atalay M, Aung T, Baldassarre D, Balkau B, Bao Y, Barnett AH, Barroso I, Basit A, Been LF, Beilby J, Bell GI, Benediktsson R, Bergman RN, Boehm BO, Boerwinkle E, Bonnycastle LL, Burtt N, Cai Q, Campbell H, Carey J, Cauchi S, Caulfield M, Chan JC, Chang LC, Chang TJ, Chang YC, Charpentier G, Chen CH, Chen H, Chen YT, Chia KS, Chidambaram M, Chines PS, Cho NH, Cho YM, Chuang LM, Collins FS, Cornelis MC, Couper DJ, Crenshaw AT, van Dam RM, Danesh J, Das D, de Faire U, Dedoussis G, Deloukas P, Dimas AS, Dina C, Doney AS, Donnelly PJ, Dorkhan M, van Duijn C, Dupuis J, Edkins S, Elliott P, Emilsson V, Erbel R, Eriksson JG, Escobedo J, Esko T, Eury E, Florez JC, Fontanillas P, Forouhi NG, Forsen T, Fox C, Fraser RM, Frayling TM, Froguel P, Frossard P, Gao Y, Gertow K, Gieger C, Gigante B, Grallert H, Grant GB, Grrop LC, Groves CJ, Grundberg E, Guiducci C, Hamsten A, Han BG, Hara K, Hassanali N, Hattersley AT, Hayward C, Hedman AK, Herder C, Hofman A, Holmen OL, Hovingh K, Hreidarsson AB, Hu C, Hu FB, Hui J, Humphries SE, Hunt SE, Hunter DJ, Hveem K, Hydrie ZI, Ikegami H, Illig T, Ingelsson E, Islam M, Isomaa B, Jackson AU, Jafar T, James A, Jia W, J?ckel KH, Jonsson A, Jowett JB, Kadowaki T, Kang HM, Kanoni S, Kao WH, Kathiresan S, Kato N, Katulanda P, Keinanen-Kiukaanniemi KM, Kelly AM, Khan H, Khaw KT, Khor CC, Kim HL, Kim S, Kim YJ, Kinnunen L, Klopp N, Kong A, Korpi-Hy?v?lti E, Kowlessur S, Kraft P, Kravic J, Kristensen MM, Krithika S, Kumar A, Kumate J, Kuusisto J, Kwak SH, Laakso M, Lagou V, Lakka TA, Langenberg C, Langford C, Lawrence R, Leander K, Lee JM, Lee NR, Li M, Li X, Li Y, Liang J, Liju S, Lim WY, Lind L, Lindgren CM, Lindholm E, Liu CT, Liu JJ, Lobbens S, Long J, Loos RJ, Lu W, Luan J, Lyssenko V, Ma RC, Maeda S, M?gi R, M?nnisto S, Matthews DR, Meigs JB, Melander O, Metspalu A, Meyer J, Mirza G, Mihailov E, Moebus S, Mohan V, Mohlke KL, Morris AD, M?hleisen TW, M?ller-Nurasyid M, Musk B, Nakamura J, Nakashima E, Navarro P, Ng PK, Nica AC, Nilsson PM, Nj?lstad I, N?then MM, Ohnaka K, Ong TH, Owen KR, Palmer CN, Pankow JS, Park KS, Parkin M, Pechlivanis S, Pedersen NL, Peltonen L, Perry JR, Peters A, Pinidiyapathirage JM, Platou CG, Potter S, Price JF, Qi L, Radha V, Rallidis L, Rasheed A, Rathman W, Rauramaa R, Raychaudhuri S, Rayner NW, Rees SD, Rehnberg E, Ripatti S, Robertson N, Roden M, Rossin EJ, Rudan I, Rybin D, Saaristo TE, Salomaa V, Saltevo J, Samuel M, Sanghera DK, Saramies J, Scott J, Scott LJ, Scott RA, Segr? AV, Sehmi J, Sennblad B, Shah N, Shah S, Shera AS, Shu XO, Shuldiner AR, Sigur?sson G, Sijbrands E, Silveira A, Sim X, Sivapalaratnam S, Small KS, So WY, Stan??kov? A, Stefansson K, Steinbach G, Steinthorsdottir V, Stirrups K, Strawbridge RJ, Stringham HM, Sun Q, Suo C, Syv?nen AC, Takayanagi R, Takeuchi F, Tay WT, Teslovich TM, Thorand B, Thorleifsson G, Thorsteinsdottir U, Tikkanen E, Trakalo J, Tremoli E, Trip MD, Tsai FJ, Tuomi T, Tuomilehto J, Uitterlinden AG, Valladares-Salgado A, Vedantam S, Veglia F, Voight BF, Wang C, Wareham NJ, Wennauer R, Wickremasinghe AR, Wilsgaard T, Wilson JF, Wiltshire S, Winckler W, Wong TY, Wood AR, Wu JY, Wu Y, Yamamoto K, Yamauchi T, Yang M, Yengo L, Yokota M, Young R, Zabaneh D, Zhang F, Zhang R, Zheng W, Zimmet PZ, Altshuler D, Bowden DW, Cho YS, Cox NJ, Cruz M, Hanis CL, Kooner J, Lee JY, Seielstad M, Teo YY, Boehnke M, Parra EJ, Chambers JC, Tai ES, McCarthy MI, Morris AP
Nature genetics46(3)234-44(2014 Mar)

Palmitoylated calnexin is a key component of the ribosome-translocon complex.
Lakkaraju AK, Abrami L, Lemmin T, Blaskovic S, Kunz B, Kihara A, Dal Peraro M, van der Goot FG
The EMBO journal31(7)1823-35(2012 Apr)

Simultaneous induction of the four subunits of the TRAP complex by ER stress accelerates ER degradation.
Nagasawa K, Higashi T, Hosokawa N, Kaufman RJ, Nagata K
EMBO reports8(5)483-9(2007 May)

The DNA sequence and analysis of human chromosome 6.
Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP, Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, Cobley V, Collier RE, Collins JE, Colman LK, Corby NR, Coville GJ, Culley KM, Dhami P, Davies J, Dunn M, Earthrowl ME, Ellington AE, Evans KA, Faulkner L, Francis MD, Frankish A, Frankland J, French L, Garner P, Garnett J, Ghori MJ, Gilby LM, Gillson CJ, Glithero RJ, Grafham DV, Grant M, Gribble S, Griffiths C, Griffiths M, Hall R, Halls KS, Hammond S, Harley JL, Hart EA, Heath PD, Heathcott R, Holmes SJ, Howden PJ, Howe KL, Howell GR, Huckle E, Humphray SJ, Humphries MD, Hunt AR, Johnson CM, Joy AA, Kay M, Keenan SJ, Kimberley AM, King A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd CR, Lloyd DM, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, Maslen GL, Matthews L, McCann OT, McLaren SJ, McLay K, McMurray A, Moore MJ, Mullikin JC, Niblett D, Nickerson T, Novik KL, Oliver K, Overton-Larty EK, Parker A, Patel R, Pearce AV, Peck AI, Phillimore B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM, Ross MT, Searle SM, Sehra HK, Sheridan E, Skuce CD, Smith S, Smith M, Spraggon L, Squares SL, Steward CA, Sycamore N, Tamlyn-Hall G, Tester J, Theaker AJ, Thomas DW, Thorpe A, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, White SS, Whitehead SL, Whittaker H, Wild A, Willey DJ, Wilmer TE, Wood JM, Wray PW, Wyatt JC, Young L, Younger RM, Bentley DR, Coulson A, Durbin R, Hubbard T, Sulston JE, Dunham I, Rogers J, Beck S
Nature425(6960)805-11(2003 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following SSR1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SSR1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu24614	NM_003144.5 Latest version!	Homo sapiens signal sequence receptor subunit 1 (SSR1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
OHu24613	NM_001292008.2 Latest version!	Homo sapiens signal sequence receptor subunit 1 (SSR1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu24614	NM_003144.4	Homo sapiens signal sequence receptor subunit 1 (SSR1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
OHu24613	NM_001292008.1	Homo sapiens signal sequence receptor subunit 1 (SSR1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SSR1 ( NM_003144.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003135.2 Homo sapiens signal sequence receptor subunit 1 (SSR1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu24614
Clone ID Related Accession (Same CDS sequence)	NM_003144.4 , NM_003144.5
Accession Version	NM_003144.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 861bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	translocon-associated protein subunit alpha isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI553058.1, BC007710.2, AL139095.15 and BM685131.1. On May 15, 2014 this sequence version replaced NM_003144.3. Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.67255.1, CR936719.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGACTCC TCCCCCGCTT GCTGCTGCTT CTCTTACTCG TGTTCCCTGC CACTGTCTTG 
TTCCGAGGCG GCCCCAGAGG CTTGTTAGCA GTGGCACAAG ATCTTACAGA GGATGAAGAA 
ACAGTAGAAG ATTCCATAAT TGAGGATGAA GATGATGAAG CCGAGGTAGA AGAAGATGAA 
CCCACAGATT TGGTAGAAGA TAAAGAGGAA GAAGATGTGT CTGGTGAACC TGAAGCTTCA 
CCGAGTGCAG ATACAACTAT ACTGTTTGTA AAAGGAGAAG ATTTTCCAGC AAATAACATT 
GTGAAGTTCC TGGTAGGCTT TACCAACAAG GGTACAGAAG ATTTTATTGT TGAATCCTTA 
GATGCCTCAT TCCGTTATCC TCAGGACTAC CAGTTTTATA TCCAGAATTT CACAGCTCTT 
CCTCTGAACA CTGTAGTGCC ACCCCAGAGA CAGGCAACTT TTGAGTACTC TTTCATTCCT 
GCAGAGCCCA TGGGCGGACG ACCATTTGGT TTGGTCATCA ATCTGAACTA CAAAGATTTG 
AACGGCAATG TATTCCAAGA TGCAGTCTTC AATCAAACAG TTACAGTTAT TGAAAGAGAG 
GATGGGTTAG ATGGAGAAAC AATCTTTATG TATATGTTCC TTGCTGGTCT TGGGCTTCTG 
GTTATTGTTG GCCTTCATCA ACTCCTAGAA TCTAGAAAGC GTAAGAGACC CATACAGAAA 
GTAGAAATGG GTACATCAAG TCAGAATGAT GTTGACATGA GTTGGATTCC TCAGGAAACA 
TTGAATCAAA TCAATAAAGC TTCACCAAGA AGGTTGCCCA GGAAACGGGC ACAGAAGAGA 
TCAGTGGGAT CTGATGAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003135.2
CDS	195..1055
Translation	MRLLPRLLLLLLLVFPATVLFRGGPRGLLAVAQDLTEDEETVEDSIIEDEDDEAEVEEDEPTDLVEDKEEEDVSGEPEASPSADTTILFVKGEDFPANNIVKFLVGFTNKGTEDFIVESLDASFRYPQDYQFYIQNFTALPLNTVVPPQRQATFEYSFIPAEPMGGRPFGLVINLNYKDLNGNVFQDAVFNQTVTVIEREDGLDGETIFMYMFLAGLGLLVIVGLHQLLESRKRKRPIQKVEMGTSSQNDVDMSWIPQETLNQINKASPRRLPRKRAQKRSVGSDE

Target ORF information:

RefSeq Version	NM_003144.4
Organism	Homo sapiens(human)
Definition	Homo sapiens signal sequence receptor subunit 1 (SSR1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003144.4

ORF Insert Sequence:

ATGAGACTCC TCCCCCGCTT GCTGCTGCTT CTCTTACTCG TGTTCCCTGC CACTGTCTTG 
TTCCGAGGCG GCCCCAGAGG CTTGTTAGCA GTGGCACAAG ATCTTACAGA GGATGAAGAA 
ACAGTAGAAG ATTCCATAAT TGAGGATGAA GATGATGAAG CCGAGGTAGA AGAAGATGAA 
CCCACAGATT TGGTAGAAGA TAAAGAGGAA GAAGATGTGT CTGGTGAACC TGAAGCTTCA 
CCGAGTGCAG ATACAACTAT ACTGTTTGTA AAAGGAGAAG ATTTTCCAGC AAATAACATT 
GTGAAGTTCC TGGTAGGCTT TACCAACAAG GGTACAGAAG ATTTTATTGT TGAATCCTTA 
GATGCCTCAT TCCGTTATCC TCAGGACTAC CAGTTTTATA TCCAGAATTT CACAGCTCTT 
CCTCTGAACA CTGTAGTGCC ACCCCAGAGA CAGGCAACTT TTGAGTACTC TTTCATTCCT 
GCAGAGCCCA TGGGCGGACG ACCATTTGGT TTGGTCATCA ATCTGAACTA CAAAGATTTG 
AACGGCAATG TATTCCAAGA TGCAGTCTTC AATCAAACAG TTACAGTTAT TGAAAGAGAG 
GATGGGTTAG ATGGAGAAAC AATCTTTATG TATATGTTCC TTGCTGGTCT TGGGCTTCTG 
GTTATTGTTG GCCTTCATCA ACTCCTAGAA TCTAGAAAGC GTAAGAGACC CATACAGAAA 
GTAGAAATGG GTACATCAAG TCAGAATGAT GTTGACATGA GTTGGATTCC TCAGGAAACA 
TTGAATCAAA TCAATAAAGC TTCACCAAGA AGGTTGCCCA GGAAACGGGC ACAGAAGAGA 
TCAGTGGGAT CTGATGAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SSR1 ( NM_003144.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_003135.2 Homo sapiens signal sequence receptor subunit 1 (SSR1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu24614
Clone ID Related Accession (Same CDS sequence)	NM_003144.4 , NM_003144.5
Accession Version	NM_003144.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 861bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-06
Organism	Homo sapiens(human)
Product	translocon-associated protein subunit alpha isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC007710.2, AL139095.15 and BM685131.1. On Nov 22, 2018 this sequence version replaced NM_003144.4. Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.54577.1, SRR1660803.67255.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000244763.9/ ENSP00000244763.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGACTCC TCCCCCGCTT GCTGCTGCTT CTCTTACTCG TGTTCCCTGC CACTGTCTTG 
TTCCGAGGCG GCCCCAGAGG CTTGTTAGCA GTGGCACAAG ATCTTACAGA GGATGAAGAA 
ACAGTAGAAG ATTCCATAAT TGAGGATGAA GATGATGAAG CCGAGGTAGA AGAAGATGAA 
CCCACAGATT TGGTAGAAGA TAAAGAGGAA GAAGATGTGT CTGGTGAACC TGAAGCTTCA 
CCGAGTGCAG ATACAACTAT ACTGTTTGTA AAAGGAGAAG ATTTTCCAGC AAATAACATT 
GTGAAGTTCC TGGTAGGCTT TACCAACAAG GGTACAGAAG ATTTTATTGT TGAATCCTTA 
GATGCCTCAT TCCGTTATCC TCAGGACTAC CAGTTTTATA TCCAGAATTT CACAGCTCTT 
CCTCTGAACA CTGTAGTGCC ACCCCAGAGA CAGGCAACTT TTGAGTACTC TTTCATTCCT 
GCAGAGCCCA TGGGCGGACG ACCATTTGGT TTGGTCATCA ATCTGAACTA CAAAGATTTG 
AACGGCAATG TATTCCAAGA TGCAGTCTTC AATCAAACAG TTACAGTTAT TGAAAGAGAG 
GATGGGTTAG ATGGAGAAAC AATCTTTATG TATATGTTCC TTGCTGGTCT TGGGCTTCTG 
GTTATTGTTG GCCTTCATCA ACTCCTAGAA TCTAGAAAGC GTAAGAGACC CATACAGAAA 
GTAGAAATGG GTACATCAAG TCAGAATGAT GTTGACATGA GTTGGATTCC TCAGGAAACA 
TTGAATCAAA TCAATAAAGC TTCACCAAGA AGGTTGCCCA GGAAACGGGC ACAGAAGAGA 
TCAGTGGGAT CTGATGAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003135.2
CDS	80..940
Translation	MRLLPRLLLLLLLVFPATVLFRGGPRGLLAVAQDLTEDEETVEDSIIEDEDDEAEVEEDEPTDLVEDKEEEDVSGEPEASPSADTTILFVKGEDFPANNIVKFLVGFTNKGTEDFIVESLDASFRYPQDYQFYIQNFTALPLNTVVPPQRQATFEYSFIPAEPMGGRPFGLVINLNYKDLNGNVFQDAVFNQTVTVIEREDGLDGETIFMYMFLAGLGLLVIVGLHQLLESRKRKRPIQKVEMGTSSQNDVDMSWIPQETLNQINKASPRRLPRKRAQKRSVGSDE

Target ORF information:

RefSeq Version	NM_003144.5
Organism	Homo sapiens(human)
Definition	Homo sapiens signal sequence receptor subunit 1 (SSR1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003144.5

ORF Insert Sequence:

ATGAGACTCC TCCCCCGCTT GCTGCTGCTT CTCTTACTCG TGTTCCCTGC CACTGTCTTG 
TTCCGAGGCG GCCCCAGAGG CTTGTTAGCA GTGGCACAAG ATCTTACAGA GGATGAAGAA 
ACAGTAGAAG ATTCCATAAT TGAGGATGAA GATGATGAAG CCGAGGTAGA AGAAGATGAA 
CCCACAGATT TGGTAGAAGA TAAAGAGGAA GAAGATGTGT CTGGTGAACC TGAAGCTTCA 
CCGAGTGCAG ATACAACTAT ACTGTTTGTA AAAGGAGAAG ATTTTCCAGC AAATAACATT 
GTGAAGTTCC TGGTAGGCTT TACCAACAAG GGTACAGAAG ATTTTATTGT TGAATCCTTA 
GATGCCTCAT TCCGTTATCC TCAGGACTAC CAGTTTTATA TCCAGAATTT CACAGCTCTT 
CCTCTGAACA CTGTAGTGCC ACCCCAGAGA CAGGCAACTT TTGAGTACTC TTTCATTCCT 
GCAGAGCCCA TGGGCGGACG ACCATTTGGT TTGGTCATCA ATCTGAACTA CAAAGATTTG 
AACGGCAATG TATTCCAAGA TGCAGTCTTC AATCAAACAG TTACAGTTAT TGAAAGAGAG 
GATGGGTTAG ATGGAGAAAC AATCTTTATG TATATGTTCC TTGCTGGTCT TGGGCTTCTG 
GTTATTGTTG GCCTTCATCA ACTCCTAGAA TCTAGAAAGC GTAAGAGACC CATACAGAAA 
GTAGAAATGG GTACATCAAG TCAGAATGAT GTTGACATGA GTTGGATTCC TCAGGAAACA 
TTGAATCAAA TCAATAAAGC TTCACCAAGA AGGTTGCCCA GGAAACGGGC ACAGAAGAGA 
TCAGTGGGAT CTGATGAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SSR1 ( NM_001292008.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001278937.1 Homo sapiens signal sequence receptor subunit 1 (SSR1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu24613
Clone ID Related Accession (Same CDS sequence)	NM_001292008.2 , NM_001292008.1
Accession Version	NM_001292008.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 657bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Homo sapiens(human)
Product	translocon-associated protein subunit alpha isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC007710.2, AL550910.3, AL139095.15 and BM685131.1. On Jun 1, 2019 this sequence version replaced NM_001292008.1. Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1.The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.75668.1, SRR1163655.436751.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN04284274 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGACTCC TCCCCCGCTT GCTGCTGCTT CTCTTACTCG TGTTCCCTGC CACTGTCTTG 
TTCCGAGGCG GCCCCAGAGG CTTGTTAGCA GTGGCACAAG ATCTTACAGA GGATGAAGAA 
ACAGTAGAAG ATTCCATAAT TGAGGATGAA GATGATGAAG CCGAGGTAGA AGAAGATGAA 
CCCACAGATT TGGTAGAAGA TAAAGAGGAA GAAGATGTGT CTGGTGAACC TGAAGCTTCA 
CCGAGTGCAG ATACAACTAT ACTGTTTGTA AAAGGAGAAG AGCCCATGGG CGGACGACCA 
TTTGGTTTGG TCATCAATCT GAACTACAAA GATTTGAACG GCAATGTATT CCAAGATGCA 
GTCTTCAATC AAACAGTTAC AGTTATTGAA AGAGAGGATG GGTTAGATGG AGAAACAATC 
TTTATGTATA TGTTCCTTGC TGGTCTTGGG CTTCTGGTTA TTGTTGGCCT TCATCAACTC 
CTAGAATCTA GAAAGCGTAA GAGACCCATA CAGAAAGTAG AAATGGGTAC ATCAAGTCAG 
AATGATGTTG ACATGAGTTG GATTCCTCAG GAAACATTGA ATCAAATCAA TAAAGCTTCA 
CCAAGAAGGT TGCCCAGGAA ACGGGCACAG AAGAGATCAG TGGGATCTGA TGAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001278937.1
CDS	80..736
Translation	MRLLPRLLLLLLLVFPATVLFRGGPRGLLAVAQDLTEDEETVEDSIIEDEDDEAEVEEDEPTDLVEDKEEEDVSGEPEASPSADTTILFVKGEEPMGGRPFGLVINLNYKDLNGNVFQDAVFNQTVTVIEREDGLDGETIFMYMFLAGLGLLVIVGLHQLLESRKRKRPIQKVEMGTSSQNDVDMSWIPQETLNQINKASPRRLPRKRAQKRSVGSDE

Target ORF information:

RefSeq Version	NM_001292008.2
Organism	Homo sapiens(human)
Definition	Homo sapiens signal sequence receptor subunit 1 (SSR1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001292008.2

ORF Insert Sequence:

ATGAGACTCC TCCCCCGCTT GCTGCTGCTT CTCTTACTCG TGTTCCCTGC CACTGTCTTG 
TTCCGAGGCG GCCCCAGAGG CTTGTTAGCA GTGGCACAAG ATCTTACAGA GGATGAAGAA 
ACAGTAGAAG ATTCCATAAT TGAGGATGAA GATGATGAAG CCGAGGTAGA AGAAGATGAA 
CCCACAGATT TGGTAGAAGA TAAAGAGGAA GAAGATGTGT CTGGTGAACC TGAAGCTTCA 
CCGAGTGCAG ATACAACTAT ACTGTTTGTA AAAGGAGAAG AGCCCATGGG CGGACGACCA 
TTTGGTTTGG TCATCAATCT GAACTACAAA GATTTGAACG GCAATGTATT CCAAGATGCA 
GTCTTCAATC AAACAGTTAC AGTTATTGAA AGAGAGGATG GGTTAGATGG AGAAACAATC 
TTTATGTATA TGTTCCTTGC TGGTCTTGGG CTTCTGGTTA TTGTTGGCCT TCATCAACTC 
CTAGAATCTA GAAAGCGTAA GAGACCCATA CAGAAAGTAG AAATGGGTAC ATCAAGTCAG 
AATGATGTTG ACATGAGTTG GATTCCTCAG GAAACATTGA ATCAAATCAA TAAAGCTTCA 
CCAAGAAGGT TGCCCAGGAA ACGGGCACAG AAGAGATCAG TGGGATCTGA TGAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SSR1 ( NM_001292008.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001278937.1 Homo sapiens signal sequence receptor subunit 1 (SSR1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu24613
Clone ID Related Accession (Same CDS sequence)	NM_001292008.2 , NM_001292008.1
Accession Version	NM_001292008.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 657bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-12-15
Organism	Homo sapiens(human)
Product	translocon-associated protein subunit alpha isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI553058.1, BC007710.2, AL550910.3, AL139095.15 and BM685131.1. Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1.The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.436751.1, SRR1803616.75668.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN04284274 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGACTCC TCCCCCGCTT GCTGCTGCTT CTCTTACTCG TGTTCCCTGC CACTGTCTTG 
TTCCGAGGCG GCCCCAGAGG CTTGTTAGCA GTGGCACAAG ATCTTACAGA GGATGAAGAA 
ACAGTAGAAG ATTCCATAAT TGAGGATGAA GATGATGAAG CCGAGGTAGA AGAAGATGAA 
CCCACAGATT TGGTAGAAGA TAAAGAGGAA GAAGATGTGT CTGGTGAACC TGAAGCTTCA 
CCGAGTGCAG ATACAACTAT ACTGTTTGTA AAAGGAGAAG AGCCCATGGG CGGACGACCA 
TTTGGTTTGG TCATCAATCT GAACTACAAA GATTTGAACG GCAATGTATT CCAAGATGCA 
GTCTTCAATC AAACAGTTAC AGTTATTGAA AGAGAGGATG GGTTAGATGG AGAAACAATC 
TTTATGTATA TGTTCCTTGC TGGTCTTGGG CTTCTGGTTA TTGTTGGCCT TCATCAACTC 
CTAGAATCTA GAAAGCGTAA GAGACCCATA CAGAAAGTAG AAATGGGTAC ATCAAGTCAG 
AATGATGTTG ACATGAGTTG GATTCCTCAG GAAACATTGA ATCAAATCAA TAAAGCTTCA 
CCAAGAAGGT TGCCCAGGAA ACGGGCACAG AAGAGATCAG TGGGATCTGA TGAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001278937.1
CDS	195..851
Translation	MRLLPRLLLLLLLVFPATVLFRGGPRGLLAVAQDLTEDEETVEDSIIEDEDDEAEVEEDEPTDLVEDKEEEDVSGEPEASPSADTTILFVKGEEPMGGRPFGLVINLNYKDLNGNVFQDAVFNQTVTVIEREDGLDGETIFMYMFLAGLGLLVIVGLHQLLESRKRKRPIQKVEMGTSSQNDVDMSWIPQETLNQINKASPRRLPRKRAQKRSVGSDE

Target ORF information:

RefSeq Version	NM_001292008.1
Organism	Homo sapiens(human)
Definition	Homo sapiens signal sequence receptor subunit 1 (SSR1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001292008.1

ORF Insert Sequence:

ATGAGACTCC TCCCCCGCTT GCTGCTGCTT CTCTTACTCG TGTTCCCTGC CACTGTCTTG 
TTCCGAGGCG GCCCCAGAGG CTTGTTAGCA GTGGCACAAG ATCTTACAGA GGATGAAGAA 
ACAGTAGAAG ATTCCATAAT TGAGGATGAA GATGATGAAG CCGAGGTAGA AGAAGATGAA 
CCCACAGATT TGGTAGAAGA TAAAGAGGAA GAAGATGTGT CTGGTGAACC TGAAGCTTCA 
CCGAGTGCAG ATACAACTAT ACTGTTTGTA AAAGGAGAAG AGCCCATGGG CGGACGACCA 
TTTGGTTTGG TCATCAATCT GAACTACAAA GATTTGAACG GCAATGTATT CCAAGATGCA 
GTCTTCAATC AAACAGTTAC AGTTATTGAA AGAGAGGATG GGTTAGATGG AGAAACAATC 
TTTATGTATA TGTTCCTTGC TGGTCTTGGG CTTCTGGTTA TTGTTGGCCT TCATCAACTC 
CTAGAATCTA GAAAGCGTAA GAGACCCATA CAGAAAGTAG AAATGGGTAC ATCAAGTCAG 
AATGATGTTG ACATGAGTTG GATTCCTCAG GAAACATTGA ATCAAATCAA TAAAGCTTCA 
CCAAGAAGGT TGCCCAGGAA ACGGGCACAG AAGAGATCAG TGGGATCTGA TGAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
Nature genetics46(3)234-44(2014 Mar)
,,,,,Mahajan A,Go MJ,Zhang W,Below JE,Gaulton KJ,Ferreira T,Horikoshi M,Johnson AD,Ng MC,Prokopenko I,Saleheen D,Wang X,Zeggini E,Abecasis GR,Adair LS,Almgren P,Atalay M,Aung T,Baldassarre D,Balkau B,Bao Y,Barnett AH,Barroso I,Basit A,Been LF,Beilby J,Bell GI,Benediktsson R,Bergman RN,Boehm BO,Boerwinkle E,Bonnycastle LL,Burtt N,Cai Q,Campbell H,Carey J,Cauchi S,Caulfield M,Chan JC,Chang LC,Chang TJ,Chang YC,Charpentier G,Chen CH,Chen H,Chen YT,Chia KS,Chidambaram M,Chines PS,Cho NH,Cho YM,Chuang LM,Collins FS,Cornelis MC,Couper DJ,Crenshaw AT,van Dam RM,Danesh J,Das D,de Faire U,Dedoussis G,Deloukas P,Dimas AS,Dina C,Doney AS,Donnelly PJ,Dorkhan M,van Duijn C,Dupuis J,Edkins S,Elliott P,Emilsson V,Erbel R,Eriksson JG,Escobedo J,Esko T,Eury E,Florez JC,Fontanillas P,Forouhi NG,Forsen T,Fox C,Fraser RM,Frayling TM,Froguel P,Frossard P,Gao Y,Gertow K,Gieger C,Gigante B,Grallert H,Grant GB,Grrop LC,Groves CJ,Grundberg E,Guiducci C,Hamsten A,Han BG,Hara K,Hassanali N,Hattersley AT,Hayward C,Hedman AK,Herder C,Hofman A,Holmen OL,Hovingh K,Hreidarsson AB,Hu C,Hu FB,Hui J,Humphries SE,Hunt SE,Hunter DJ,Hveem K,Hydrie ZI,Ikegami H,Illig T,Ingelsson E,Islam M,Isomaa B,Jackson AU,Jafar T,James A,Jia W,J?ckel KH,Jonsson A,Jowett JB,Kadowaki T,Kang HM,Kanoni S,Kao WH,Kathiresan S,Kato N,Katulanda P,Keinanen-Kiukaanniemi KM,Kelly AM,Khan H,Khaw KT,Khor CC,Kim HL,Kim S,Kim YJ,Kinnunen L,Klopp N,Kong A,Korpi-Hy?v?lti E,Kowlessur S,Kraft P,Kravic J,Kristensen MM,Krithika S,Kumar A,Kumate J,Kuusisto J,Kwak SH,Laakso M,Lagou V,Lakka TA,Langenberg C,Langford C,Lawrence R,Leander K,Lee JM,Lee NR,Li M,Li X,Li Y,Liang J,Liju S,Lim WY,Lind L,Lindgren CM,Lindholm E,Liu CT,Liu JJ,Lobbens S,Long J,Loos RJ,Lu W,Luan J,Lyssenko V,Ma RC,Maeda S,M?gi R,M?nnisto S,Matthews DR,Meigs JB,Melander O,Metspalu A,Meyer J,Mirza G,Mihailov E,Moebus S,Mohan V,Mohlke KL,Morris AD,M?hleisen TW,M?ller-Nurasyid M,Musk B,Nakamura J,Nakashima E,Navarro P,Ng PK,Nica AC,Nilsson PM,Nj?lstad I,N?then MM,Ohnaka K,Ong TH,Owen KR,Palmer CN,Pankow JS,Park KS,Parkin M,Pechlivanis S,Pedersen NL,Peltonen L,Perry JR,Peters A,Pinidiyapathirage JM,Platou CG,Potter S,Price JF,Qi L,Radha V,Rallidis L,Rasheed A,Rathman W,Rauramaa R,Raychaudhuri S,Rayner NW,Rees SD,Rehnberg E,Ripatti S,Robertson N,Roden M,Rossin EJ,Rudan I,Rybin D,Saaristo TE,Salomaa V,Saltevo J,Samuel M,Sanghera DK,Saramies J,Scott J,Scott LJ,Scott RA,Segr? AV,Sehmi J,Sennblad B,Shah N,Shah S,Shera AS,Shu XO,Shuldiner AR,Sigur?sson G,Sijbrands E,Silveira A,Sim X,Sivapalaratnam S,Small KS,So WY,Stan??kov? A,Stefansson K,Steinbach G,Steinthorsdottir V,Stirrups K,Strawbridge RJ,Stringham HM,Sun Q,Suo C,Syv?nen AC,Takayanagi R,Takeuchi F,Tay WT,Teslovich TM,Thorand B,Thorleifsson G,Thorsteinsdottir U,Tikkanen E,Trakalo J,Tremoli E,Trip MD,Tsai FJ,Tuomi T,Tuomilehto J,Uitterlinden AG,Valladares-Salgado A,Vedantam S,Veglia F,Voight BF,Wang C,Wareham NJ,Wennauer R,Wickremasinghe AR,Wilsgaard T,Wilson JF,Wiltshire S,Winckler W,Wong TY,Wood AR,Wu JY,Wu Y,Yamamoto K,Yamauchi T,Yang M,Yengo L,Yokota M,Young R,Zabaneh D,Zhang F,Zhang R,Zheng W,Zimmet PZ,Altshuler D,Bowden DW,Cho YS,Cox NJ,Cruz M,Hanis CL,Kooner J,Lee JY,Seielstad M,Teo YY,Boehnke M,Parra EJ,Chambers JC,Tai ES,McCarthy MI,Morris AP

Palmitoylated calnexin is a key component of the ribosome-translocon complex.
The EMBO journal31(7)1823-35(2012 Apr)
Lakkaraju AK,Abrami L,Lemmin T,Blaskovic S,Kunz B,Kihara A,Dal Peraro M,van der Goot FG

Simultaneous induction of the four subunits of the TRAP complex by ER stress accelerates ER degradation.
EMBO reports8(5)483-9(2007 May)
Nagasawa K,Higashi T,Hosokawa N,Kaufman RJ,Nagata K

The DNA sequence and analysis of human chromosome 6.
Nature425(6960)805-11(2003 Oct)
Mungall AJ,Palmer SA,Sims SK,Edwards CA,Ashurst JL,Wilming L,Jones MC,Horton R,Hunt SE,Scott CE,Gilbert JG,Clamp ME,Bethel G,Milne S,Ainscough R,Almeida JP,Ambrose KD,Andrews TD,Ashwell RI,Babbage AK,Bagguley CL,Bailey J,Banerjee R,Barker DJ,Barlow KF,Bates K,Beare DM,Beasley H,Beasley O,Bird CP,Blakey S,Bray-Allen S,Brook J,Brown AJ,Brown JY,Burford DC,Burrill W,Burton J,Carder C,Carter NP,Chapman JC,Clark SY,Clark G,Clee CM,Clegg S,Cobley V,Collier RE,Collins JE,Colman LK,Corby NR,Coville GJ,Culley KM,Dhami P,Davies J,Dunn M,Earthrowl ME,Ellington AE,Evans KA,Faulkner L,Francis MD,Frankish A,Frankland J,French L,Garner P,Garnett J,Ghori MJ,Gilby LM,Gillson CJ,Glithero RJ,Grafham DV,Grant M,Gribble S,Griffiths C,Griffiths M,Hall R,Halls KS,Hammond S,Harley JL,Hart EA,Heath PD,Heathcott R,Holmes SJ,Howden PJ,Howe KL,Howell GR,Huckle E,Humphray SJ,Humphries MD,Hunt AR,Johnson CM,Joy AA,Kay M,Keenan SJ,Kimberley AM,King A,Laird GK,Langford C,Lawlor S,Leongamornlert DA,Leversha M,Lloyd CR,Lloyd DM,Loveland JE,Lovell J,Martin S,Mashreghi-Mohammadi M,Maslen GL,Matthews L,McCann OT,McLaren SJ,McLay K,McMurray A,Moore MJ,Mullikin JC,Niblett D,Nickerson T,Novik KL,Oliver K,Overton-Larty EK,Parker A,Patel R,Pearce AV,Peck AI,Phillimore B,Phillips S,Plumb RW,Porter KM,Ramsey Y,Ranby SA,Rice CM,Ross MT,Searle SM,Sehra HK,Sheridan E,Skuce CD,Smith S,Smith M,Spraggon L,Squares SL,Steward CA,Sycamore N,Tamlyn-Hall G,Tester J,Theaker AJ,Thomas DW,Thorpe A,Tracey A,Tromans A,Tubby B,Wall M,Wallis JM,West AP,White SS,Whitehead SL,Whittaker H,Wild A,Willey DJ,Wilmer TE,Wood JM,Wray PW,Wyatt JC,Young L,Younger RM,Bentley DR,Coulson A,Durbin R,Hubbard T,Sulston JE,Dunham I,Rogers J,Beck S

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SSR1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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