SP3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SP3
Entrez Gene ID	6670
Full Name	Sp3 transcription factor
Synonyms	SPR2
General protein information	Preferred Names Sp3 transcription factor Names transcription factor Sp3 GC-binding transcription factor Sp3 specificity protein 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q31.1
Summary	This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted. A related pseudogene has been identified on chromosome 13. [provided by RefSeq, Feb 2010].
Disorder MIM:	601804

mRNA and Protein(s)

mRNA	Protein	Name
NM_001017371.4	NP_001017371.3	transcription factor Sp3 isoform 2
NM_003111.4	NP_003102.1	transcription factor Sp3 isoform 1
NM_001017371.5	NP_001017371.3	transcription factor Sp3 isoform 2
NM_001172712.1	NP_001166183.1	transcription factor Sp3 isoform 3

Pathways from BioSystems

Homologies

	SP3	XP_001088331.2
Rattus norvegicus (Norway rat)	Sp3	XP_002729217.3
Danio rerio (zebrafish)	sp3a	NP_001082967.1
Gallus gallus (chicken)	SP3	NP_989934.1
Xenopus tropicalis (tropical clawed frog)	sp3	XP_002934651.1
Mus musculus (house mouse)	Sp3	NP_001018052.1
Homo sapiens (human)	SP3	NP_003102.1
Canis lupus familiaris (dog)	SP3	XP_005640384.1
Bos taurus (cattle)	SP3	XP_002685342.2

Gene Ontology
Bibliography

Related articles in PubMed

A type 2 diabetes-associated SNP in KCNQ1 (rs163184) modulates the binding activity of the locus for Sp3 and Lsd1/Kdm1a, potentially affecting CDKN1C expression.
Hiramoto M, Udagawa H, Ishibashi N, Takahashi E, Kaburagi Y, Miyazawa K, Funahashi N, Nammo T, Yasuda K
International journal of molecular medicine41(2)717-728(2018 Feb)

The miR-491-3p/Sp3/ABCB1 axis attenuates multidrug resistance of hepatocellular carcinoma.
Zhao Y, Qi X, Chen J, Wei W, Yu C, Yan H, Pu M, Li Y, Miao L, Li C, Ren J
Cancer letters408102-111(2017 Nov)

Minimal essential region for kr?ppel-like factor 5 expression and the regulation by specificity protein 3-GC box binding.
Mihara N, Chiba T, Yamaguchi K, Sudo H, Yagishita H, Imai K
Gene60136-43(2017 Feb)

Trefoil factor family 2 expression inhibits gastric cancer cell growth and invasion in?vitro via interactions with the transcription factor Sp3.
Cai Y, Yi M, Chen D, Liu J, Guleng B, Ren J, Shi H
International journal of molecular medicine38(5)1474-1480(2016 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

High SP3 expression is associated with hepatocellular carcinoma.
Title: The miR-491-3p/Sp3/ABCB1 axis attenuates multidrug resistance of hepatocellular carcinoma.

demonstrate that a 186bp region is the minimal essential region and that Sp3-GC1 binding is essential to the basal expression of KLF5
Title: Minimal essential region for kr?ppel-like factor 5 expression and the regulation by specificity protein 3-GC box binding.

Data indicate that the antitumor activity of trefoil factor 2 (TFF2) is mediated by an interaction with the transcription factor Sp3 (Sp3) in gastric cancer cells.
Title: Trefoil factor family 2 expression inhibits gastric cancer cell growth and invasion in?vitro via interactions with the transcription factor Sp3.

we established a new regulatory model of COL1A1 regulation by HIF-1, and bring out its relationship with Sp3 transcription factor. In a fundamental level, these findings give insights in the mechanisms controlling COL1A1 gene expression.
Title: Hypoxia inducible factor 1 alpha down-regulates type i collagen through Sp3 transcription factor in human chondrocytes.

Sp1, Sp3 and Sp4 are non-oncogene addiction (NOA) genes and are attractive drug targets for individual and combined cancer chemotherapies.
Title: Specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 are non-oncogene addiction genes in cancer cells.

The following SP3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SP3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu28260	NM_003111.4 Latest version!	Homo sapiens Sp3 transcription factor (SP3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu13923	NM_001017371.5 Latest version!	Homo sapiens Sp3 transcription factor (SP3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$265.30 $379.00
OHu28261	NM_001172712.1 Latest version!	Homo sapiens Sp3 transcription factor (SP3), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$265.30 $379.00
View Old Accession Versions >>
OHu13923	NM_001017371.4	Homo sapiens Sp3 transcription factor (SP3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$265.30 $379.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SP3 ( NM_003111.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003102.1 Homo sapiens Sp3 transcription factor (SP3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu28260
Clone ID Related Accession (Same CDS sequence)	NM_003111.4
Accession Version	NM_003111.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2346bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Homo sapiens(human)
Product	transcription factor Sp3 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY441957.1, AY070137.1, M97191.2, BC042945.2 and AC093399.6. This sequence is a reference standard in the RefSeqGene project. On Feb 20, 2010 this sequence version replaced NM_003111.3. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Alternative translation initiation from downstream, in-frame start codons produces shorter isoforms. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY441957.1, SRR1660809.223965.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein regulatory uORF :: PMID: 15247228 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGACCGCTC CCGAAAAGCC CGTGAAACAA GAGGAAATGG CTGCCTTGGA CGTGGATAGC 
GGCGGCGGCG GTGGCGGCGG CGGCGGCCAC GGCGAGTATC TGCAGCAGCA GCAACAGCAC 
GGAAACGGTG CGGTGGCGGC GGCAGCGGCG GCCCAGGACA CTCAGCCGTC ACCGCTCGCT 
CTGCTGGCCG CTACCTGCAG CAAGATAGGG CCGCCATCGC CGGGCGACGA CGAGGAGGAG 
GCGGCCGCCG CAGCCGGGGC CCCCGCCGCC GCCGGAGCGA CAGGTGATTT GGCTTCTGCA 
CAGTTAGGAG GAGCACCAAA CCGATGGGAG GTTTTGTCAG CCACACCTAC AACTATAAAA 
GATGAAGCTG GTAATCTAGT CCAGATTCCA AGTGCTGCTA CTTCAAGTGG GCAGTATGTT 
CTTCCCCTTC AGAATTTGCA GAATCAACAA ATATTTTCCG TTGCACCAGG ATCAGATTCA 
TCAAATGGTA CAGTGTCCAG TGTTCAATAT CAAGTGATAC CACAGATCCA GTCAGCAGAT 
GGTCAGCAGG TTCAAATTGG TTTCACAGGC TCTTCAGATA ATGGGGGTAT AAATCAAGAA 
AGCAGTCAAA TTCAGATCAT TCCTGGCTCT AATCAAACCT TACTTGCCTC TGGAACACCT 
TCTGCTAACA TCCAGAATCT CATACCACAG ACTGGTCAAG TCCAGGTTCA GGGAGTTGCA 
ATTGGTGGTT CATCTTTTCC TGGTCAAACC CAAGTAGTTG CTAATGTGCC TCTTGGTCTG 
CCAGGAAATA TTACGTTTGT ACCAATCAAT AGTGTCGATC TAGATTCTTT GGGACTCTCG 
GGCAGTTCTC AGACAATGAC TGCAGGCATT AATGCCGACG GACATTTGAT AAACACAGGA 
CAAGCTATGG ATAGTTCAGA CAATTCAGAA AGGACTGGTG AGCGGGTTTC TCCTGATATT 
AATGAAACTA ATACTGATAC AGATTTATTT GTGCCAACAT CCTCTTCATC ACAGTTGCCT 
GTTACGATAG ATAGTACAGG TATATTACAA CAAAACACAA ATAGCTTGAC TACATCTAGT 
GGGCAGGTTC ATTCTTCAGA TCTTCAGGGA AATTATATCC AGTCGCCTGT TTCTGAAGAG 
ACACAGGCAC AGAATATTCA GGTTTCTACA GCACAGCCTG TTGTACAGCA TCTACAACTT 
CAAGAGTCTC AGCAGCCAAC CAGTCAAGCC CAAATTGTGC AAGGTATTAC ACCACAGACA 
ATCCATGGTG TGCAAGCCAG TGGTCAAAAT ATATCACAAC AGGCTTTGCA AAATCTTCAG 
TTGCAGCTGA ATCCTGGAAC CTTTTTAATT CAGGCACAGA CAGTGACCCC TTCTGGACAG 
GTAACTTGGC AAACGTTTCA AGTACAAGGG GTCCAGAACT TGCAGAATTT GCAAATACAG 
AATACTGCTG CCCAACAAAT AACTTTGACG CCTGTTCAAA CCCTCACACT TGGTCAAGTT 
GCGGCAGGTG GAGCCTTCAC TTCAACTCCA GTTAGTCTAA GCACTGGTCA GTTGCCAAAT 
CTACAAACAG TTACAGTGAA CTCTATAGAT TCTGCTGGTA TACAGCTACA TCCAGGAGAG 
AATGCTGACA GTCCTGCAGA TATTAGGATC AAGGAAGAAG AACCTGATCC TGAAGAGTGG 
CAGCTCAGTG GTGATTCTAC CTTGAATACC AATGACCTAA CACACTTAAG AGTACAGGTG 
GTAGATGAAG AAGGGGACCA ACAACATCAA GAAGGAAAAA GACTTCGGAG GGTAGCTTGC 
ACCTGTCCCA ACTGTAAAGA AGGTGGTGGA AGAGGTACCA ATCTTGGGAA AAAGAAGCAA 
CACATTTGTC ATATACCAGG ATGTGGTAAA GTCTATGGGA AGACCTCACA TCTGAGAGCT 
CATCTGCGTT GGCATTCTGG AGAACGCCCT TTTGTTTGTA ACTGGATGTA CTGTGGTAAA 
AGATTTACTC GAAGTGATGA ATTACAGAGG CACAGAAGAA CACATACAGG TGAGAAGAAA 
TTTGTTTGTC CAGAATGTTC AAAACGCTTT ATGAGAAGTG ACCACCTTGC CAAACATATT 
AAAACACACC AGAATAAAAA AGGTATTCAC TCTAGCAGTA CAGTGCTGGC ATCTGTGGAA 
GCTGCGCGAG ATGATACTTT GATTACTGCA GGAGGAACAA CGCTTATCCT TGCAAATATT 
CAACAAGGTT CTGTTTCAGG GATAGGAACT GTTAATACTT CCGCCACCAG CAATCAAGAT 
ATCCTTACCA ACACTGAAAT ACCTTTACAG CTTGTCACAG TTTCTGGAAA TGAGACAATG 
GAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003102.1
CDS	532..2877
Translation	MTAPEKPVKQEEMAALDVDSGGGGGGGGGHGEYLQQQQQHGNGAVAAAAAAQDTQPSPLALLAATCSKIGPPSPGDDEEEAAAAAGAPAAAGATGDLASAQLGGAPNRWEVLSATPTTIKDEAGNLVQIPSAATSSGQYVLPLQNLQNQQIFSVAPGSDSSNGTVSSVQYQVIPQIQSADGQQVQIGFTGSSDNGGINQESSQIQIIPGSNQTLLASGTPSANIQNLIPQTGQVQVQGVAIGGSSFPGQTQVVANVPLGLPGNITFVPINSVDLDSLGLSGSSQTMTAGINADGHLINTGQAMDSSDNSERTGERVSPDINETNTDTDLFVPTSSSSQLPVTIDSTGILQQNTNSLTTSSGQVHSSDLQGNYIQSPVSEETQAQNIQVSTAQPVVQHLQLQESQQPTSQAQIVQGITPQTIHGVQASGQNISQQALQNLQLQLNPGTFLIQAQTVTPSGQVTWQTFQVQGVQNLQNLQIQNTAAQQITLTPVQTLTLGQVAAGGAFTSTPVSLSTGQLPNLQTVTVNSIDSAGIQLHPGENADSPADIRIKEEEPDPEEWQLSGDSTLNTNDLTHLRVQVVDEEGDQQHQEGKRLRRVACTCPNCKEGGGRGTNLGKKKQHICHIPGCGKVYGKTSHLRAHLRWHSGERPFVCNWMYCGKRFTRSDELQRHRRTHTGEKKFVCPECSKRFMRSDHLAKHIKTHQNKKGIHSSSTVLASVEAARDDTLITAGGTTLILANIQQGSVSGIGTVNTSATSNQDILTNTEIPLQLVTVSGNETME

Target ORF information:

RefSeq Version	NM_003111.4
Organism	Homo sapiens(human)
Definition	Homo sapiens Sp3 transcription factor (SP3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003111.4

ORF Insert Sequence:

ATGACCGCTC CCGAAAAGCC CGTGAAACAA GAGGAAATGG CTGCCTTGGA CGTGGATAGC 
GGCGGCGGCG GTGGCGGCGG CGGCGGCCAC GGCGAGTATC TGCAGCAGCA GCAACAGCAC 
GGAAACGGTG CGGTGGCGGC GGCAGCGGCG GCCCAGGACA CTCAGCCGTC ACCGCTCGCT 
CTGCTGGCCG CTACCTGCAG CAAGATAGGG CCGCCATCGC CGGGCGACGA CGAGGAGGAG 
GCGGCCGCCG CAGCCGGGGC CCCCGCCGCC GCCGGAGCGA CAGGTGATTT GGCTTCTGCA 
CAGTTAGGAG GAGCACCAAA CCGATGGGAG GTTTTGTCAG CCACACCTAC AACTATAAAA 
GATGAAGCTG GTAATCTAGT CCAGATTCCA AGTGCTGCTA CTTCAAGTGG GCAGTATGTT 
CTTCCCCTTC AGAATTTGCA GAATCAACAA ATATTTTCCG TTGCACCAGG ATCAGATTCA 
TCAAATGGTA CAGTGTCCAG TGTTCAATAT CAAGTGATAC CACAGATCCA GTCAGCAGAT 
GGTCAGCAGG TTCAAATTGG TTTCACAGGC TCTTCAGATA ATGGGGGTAT AAATCAAGAA 
AGCAGTCAAA TTCAGATCAT TCCTGGCTCT AATCAAACCT TACTTGCCTC TGGAACACCT 
TCTGCTAACA TCCAGAATCT CATACCACAG ACTGGTCAAG TCCAGGTTCA GGGAGTTGCA 
ATTGGTGGTT CATCTTTTCC TGGTCAAACC CAAGTAGTTG CTAATGTGCC TCTTGGTCTG 
CCAGGAAATA TTACGTTTGT ACCAATCAAT AGTGTCGATC TAGATTCTTT GGGACTCTCG 
GGCAGTTCTC AGACAATGAC TGCAGGCATT AATGCCGACG GACATTTGAT AAACACAGGA 
CAAGCTATGG ATAGTTCAGA CAATTCAGAA AGGACTGGTG AGCGGGTTTC TCCTGATATT 
AATGAAACTA ATACTGATAC AGATTTATTT GTGCCAACAT CCTCTTCATC ACAGTTGCCT 
GTTACGATAG ATAGTACAGG TATATTACAA CAAAACACAA ATAGCTTGAC TACATCTAGT 
GGGCAGGTTC ATTCTTCAGA TCTTCAGGGA AATTATATCC AGTCGCCTGT TTCTGAAGAG 
ACACAGGCAC AGAATATTCA GGTTTCTACA GCACAGCCTG TTGTACAGCA TCTACAACTT 
CAAGAGTCTC AGCAGCCAAC CAGTCAAGCC CAAATTGTGC AAGGTATTAC ACCACAGACA 
ATCCATGGTG TGCAAGCCAG TGGTCAAAAT ATATCACAAC AGGCTTTGCA AAATCTTCAG 
TTGCAGCTGA ATCCTGGAAC CTTTTTAATT CAGGCACAGA CAGTGACCCC TTCTGGACAG 
GTAACTTGGC AAACGTTTCA AGTACAAGGG GTCCAGAACT TGCAGAATTT GCAAATACAG 
AATACTGCTG CCCAACAAAT AACTTTGACG CCTGTTCAAA CCCTCACACT TGGTCAAGTT 
GCGGCAGGTG GAGCCTTCAC TTCAACTCCA GTTAGTCTAA GCACTGGTCA GTTGCCAAAT 
CTACAAACAG TTACAGTGAA CTCTATAGAT TCTGCTGGTA TACAGCTACA TCCAGGAGAG 
AATGCTGACA GTCCTGCAGA TATTAGGATC AAGGAAGAAG AACCTGATCC TGAAGAGTGG 
CAGCTCAGTG GTGATTCTAC CTTGAATACC AATGACCTAA CACACTTAAG AGTACAGGTG 
GTAGATGAAG AAGGGGACCA ACAACATCAA GAAGGAAAAA GACTTCGGAG GGTAGCTTGC 
ACCTGTCCCA ACTGTAAAGA AGGTGGTGGA AGAGGTACCA ATCTTGGGAA AAAGAAGCAA 
CACATTTGTC ATATACCAGG ATGTGGTAAA GTCTATGGGA AGACCTCACA TCTGAGAGCT 
CATCTGCGTT GGCATTCTGG AGAACGCCCT TTTGTTTGTA ACTGGATGTA CTGTGGTAAA 
AGATTTACTC GAAGTGATGA ATTACAGAGG CACAGAAGAA CACATACAGG TGAGAAGAAA 
TTTGTTTGTC CAGAATGTTC AAAACGCTTT ATGAGAAGTG ACCACCTTGC CAAACATATT 
AAAACACACC AGAATAAAAA AGGTATTCAC TCTAGCAGTA CAGTGCTGGC ATCTGTGGAA 
GCTGCGCGAG ATGATACTTT GATTACTGCA GGAGGAACAA CGCTTATCCT TGCAAATATT 
CAACAAGGTT CTGTTTCAGG GATAGGAACT GTTAATACTT CCGCCACCAG CAATCAAGAT 
ATCCTTACCA ACACTGAAAT ACCTTTACAG CTTGTCACAG TTTCTGGAAA TGAGACAATG 
GAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SP3 ( NM_001017371.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001017371.3 Homo sapiens Sp3 transcription factor (SP3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu13923
Clone ID Related Accession (Same CDS sequence)	NM_001017371.4 , NM_001017371.5
Accession Version	NM_001017371.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2142bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-07-28
Organism	Homo sapiens(human)
Product	transcription factor Sp3 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY070137.1, M97191.2, AB209334.1 and BQ010796.1. On Feb 20, 2010 this sequence version replaced NM_001017371.3. Transcript Variant: This variant (2) is missing exons 1 and 2 found in transcript variant 1, and has a different 5' end. It initiates translation from a non-AUG (AUA) start site, and encodes an isoform (2) with a shorter N-terminus compared to isoform 1. Alternative translation initiation from downstream, in-frame AUG start codons produces shorter isoforms. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY070137.1, SRR1660807.232460.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## non-AUG initiation codon :: PMID: 12297010 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATAGGGCCGC CATCGCCGGG CGACGACGAG GAGGAGGCGG CCGCCGCAGC CGGGGCCCCC 
GCCGCCGCCG GAGCGACAGG TGATTTGGCT TCTGCACAGT TAGGAGGAGC ACCAAACCGA 
TGGGAGGTTT TGTCAGCCAC ACCTACAACT ATAAAAGATG AAGCTGGTAA TCTAGTCCAG 
ATTCCAAGTG CTGCTACTTC AAGTGGGCAG TATGTTCTTC CCCTTCAGAA TTTGCAGAAT 
CAACAAATAT TTTCCGTTGC ACCAGGATCA GATTCATCAA ATGGTACAGT GTCCAGTGTT 
CAATATCAAG TGATACCACA GATCCAGTCA GCAGATGGTC AGCAGGTTCA AATTGGTTTC 
ACAGGCTCTT CAGATAATGG GGGTATAAAT CAAGAAAGCA GTCAAATTCA GATCATTCCT 
GGCTCTAATC AAACCTTACT TGCCTCTGGA ACACCTTCTG CTAACATCCA GAATCTCATA 
CCACAGACTG GTCAAGTCCA GGTTCAGGGA GTTGCAATTG GTGGTTCATC TTTTCCTGGT 
CAAACCCAAG TAGTTGCTAA TGTGCCTCTT GGTCTGCCAG GAAATATTAC GTTTGTACCA 
ATCAATAGTG TCGATCTAGA TTCTTTGGGA CTCTCGGGCA GTTCTCAGAC AATGACTGCA 
GGCATTAATG CCGACGGACA TTTGATAAAC ACAGGACAAG CTATGGATAG TTCAGACAAT 
TCAGAAAGGA CTGGTGAGCG GGTTTCTCCT GATATTAATG AAACTAATAC TGATACAGAT 
TTATTTGTGC CAACATCCTC TTCATCACAG TTGCCTGTTA CGATAGATAG TACAGGTATA 
TTACAACAAA ACACAAATAG CTTGACTACA TCTAGTGGGC AGGTTCATTC TTCAGATCTT 
CAGGGAAATT ATATCCAGTC GCCTGTTTCT GAAGAGACAC AGGCACAGAA TATTCAGGTT 
TCTACAGCAC AGCCTGTTGT ACAGCATCTA CAACTTCAAG AGTCTCAGCA GCCAACCAGT 
CAAGCCCAAA TTGTGCAAGG TATTACACCA CAGACAATCC ATGGTGTGCA AGCCAGTGGT 
CAAAATATAT CACAACAGGC TTTGCAAAAT CTTCAGTTGC AGCTGAATCC TGGAACCTTT 
TTAATTCAGG CACAGACAGT GACCCCTTCT GGACAGGTAA CTTGGCAAAC GTTTCAAGTA 
CAAGGGGTCC AGAACTTGCA GAATTTGCAA ATACAGAATA CTGCTGCCCA ACAAATAACT 
TTGACGCCTG TTCAAACCCT CACACTTGGT CAAGTTGCGG CAGGTGGAGC CTTCACTTCA 
ACTCCAGTTA GTCTAAGCAC TGGTCAGTTG CCAAATCTAC AAACAGTTAC AGTGAACTCT 
ATAGATTCTG CTGGTATACA GCTACATCCA GGAGAGAATG CTGACAGTCC TGCAGATATT 
AGGATCAAGG AAGAAGAACC TGATCCTGAA GAGTGGCAGC TCAGTGGTGA TTCTACCTTG 
AATACCAATG ACCTAACACA CTTAAGAGTA CAGGTGGTAG ATGAAGAAGG GGACCAACAA 
CATCAAGAAG GAAAAAGACT TCGGAGGGTA GCTTGCACCT GTCCCAACTG TAAAGAAGGT 
GGTGGAAGAG GTACCAATCT TGGGAAAAAG AAGCAACACA TTTGTCATAT ACCAGGATGT 
GGTAAAGTCT ATGGGAAGAC CTCACATCTG AGAGCTCATC TGCGTTGGCA TTCTGGAGAA 
CGCCCTTTTG TTTGTAACTG GATGTACTGT GGTAAAAGAT TTACTCGAAG TGATGAATTA 
CAGAGGCACA GAAGAACACA TACAGGTGAG AAGAAATTTG TTTGTCCAGA ATGTTCAAAA 
CGCTTTATGA GAAGTGACCA CCTTGCCAAA CATATTAAAA CACACCAGAA TAAAAAAGGT 
ATTCACTCTA GCAGTACAGT GCTGGCATCT GTGGAAGCTG CGCGAGATGA TACTTTGATT 
ACTGCAGGAG GAACAACGCT TATCCTTGCA AATATTCAAC AAGGTTCTGT TTCAGGGATA 
GGAACTGTTA ATACTTCCGC CACCAGCAAT CAAGATATCC TTACCAACAC TGAAATACCT 
TTACAGCTTG TCACAGTTTC TGGAAATGAG ACAATGGAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001017371.3
CDS	385..2526
Translation	IGPPSPGDDEEEAAAAAGAPAAAGATGDLASAQLGGAPNRWEVLSATPTTIKDEAGNLVQIPSAATSSGQYVLPLQNLQNQQIFSVAPGSDSSNGTVSSVQYQVIPQIQSADGQQVQIGFTGSSDNGGINQESSQIQIIPGSNQTLLASGTPSANIQNLIPQTGQVQVQGVAIGGSSFPGQTQVVANVPLGLPGNITFVPINSVDLDSLGLSGSSQTMTAGINADGHLINTGQAMDSSDNSERTGERVSPDINETNTDTDLFVPTSSSSQLPVTIDSTGILQQNTNSLTTSSGQVHSSDLQGNYIQSPVSEETQAQNIQVSTAQPVVQHLQLQESQQPTSQAQIVQGITPQTIHGVQASGQNISQQALQNLQLQLNPGTFLIQAQTVTPSGQVTWQTFQVQGVQNLQNLQIQNTAAQQITLTPVQTLTLGQVAAGGAFTSTPVSLSTGQLPNLQTVTVNSIDSAGIQLHPGENADSPADIRIKEEEPDPEEWQLSGDSTLNTNDLTHLRVQVVDEEGDQQHQEGKRLRRVACTCPNCKEGGGRGTNLGKKKQHICHIPGCGKVYGKTSHLRAHLRWHSGERPFVCNWMYCGKRFTRSDELQRHRRTHTGEKKFVCPECSKRFMRSDHLAKHIKTHQNKKGIHSSSTVLASVEAARDDTLITAGGTTLILANIQQGSVSGIGTVNTSATSNQDILTNTEIPLQLVTVSGNETME

Target ORF information:

RefSeq Version	NM_001017371.4
Organism	Homo sapiens(human)
Definition	Homo sapiens Sp3 transcription factor (SP3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001017371.4

ORF Insert Sequence:

ATAGGGCCGC CATCGCCGGG CGACGACGAG GAGGAGGCGG CCGCCGCAGC CGGGGCCCCC 
GCCGCCGCCG GAGCGACAGG TGATTTGGCT TCTGCACAGT TAGGAGGAGC ACCAAACCGA 
TGGGAGGTTT TGTCAGCCAC ACCTACAACT ATAAAAGATG AAGCTGGTAA TCTAGTCCAG 
ATTCCAAGTG CTGCTACTTC AAGTGGGCAG TATGTTCTTC CCCTTCAGAA TTTGCAGAAT 
CAACAAATAT TTTCCGTTGC ACCAGGATCA GATTCATCAA ATGGTACAGT GTCCAGTGTT 
CAATATCAAG TGATACCACA GATCCAGTCA GCAGATGGTC AGCAGGTTCA AATTGGTTTC 
ACAGGCTCTT CAGATAATGG GGGTATAAAT CAAGAAAGCA GTCAAATTCA GATCATTCCT 
GGCTCTAATC AAACCTTACT TGCCTCTGGA ACACCTTCTG CTAACATCCA GAATCTCATA 
CCACAGACTG GTCAAGTCCA GGTTCAGGGA GTTGCAATTG GTGGTTCATC TTTTCCTGGT 
CAAACCCAAG TAGTTGCTAA TGTGCCTCTT GGTCTGCCAG GAAATATTAC GTTTGTACCA 
ATCAATAGTG TCGATCTAGA TTCTTTGGGA CTCTCGGGCA GTTCTCAGAC AATGACTGCA 
GGCATTAATG CCGACGGACA TTTGATAAAC ACAGGACAAG CTATGGATAG TTCAGACAAT 
TCAGAAAGGA CTGGTGAGCG GGTTTCTCCT GATATTAATG AAACTAATAC TGATACAGAT 
TTATTTGTGC CAACATCCTC TTCATCACAG TTGCCTGTTA CGATAGATAG TACAGGTATA 
TTACAACAAA ACACAAATAG CTTGACTACA TCTAGTGGGC AGGTTCATTC TTCAGATCTT 
CAGGGAAATT ATATCCAGTC GCCTGTTTCT GAAGAGACAC AGGCACAGAA TATTCAGGTT 
TCTACAGCAC AGCCTGTTGT ACAGCATCTA CAACTTCAAG AGTCTCAGCA GCCAACCAGT 
CAAGCCCAAA TTGTGCAAGG TATTACACCA CAGACAATCC ATGGTGTGCA AGCCAGTGGT 
CAAAATATAT CACAACAGGC TTTGCAAAAT CTTCAGTTGC AGCTGAATCC TGGAACCTTT 
TTAATTCAGG CACAGACAGT GACCCCTTCT GGACAGGTAA CTTGGCAAAC GTTTCAAGTA 
CAAGGGGTCC AGAACTTGCA GAATTTGCAA ATACAGAATA CTGCTGCCCA ACAAATAACT 
TTGACGCCTG TTCAAACCCT CACACTTGGT CAAGTTGCGG CAGGTGGAGC CTTCACTTCA 
ACTCCAGTTA GTCTAAGCAC TGGTCAGTTG CCAAATCTAC AAACAGTTAC AGTGAACTCT 
ATAGATTCTG CTGGTATACA GCTACATCCA GGAGAGAATG CTGACAGTCC TGCAGATATT 
AGGATCAAGG AAGAAGAACC TGATCCTGAA GAGTGGCAGC TCAGTGGTGA TTCTACCTTG 
AATACCAATG ACCTAACACA CTTAAGAGTA CAGGTGGTAG ATGAAGAAGG GGACCAACAA 
CATCAAGAAG GAAAAAGACT TCGGAGGGTA GCTTGCACCT GTCCCAACTG TAAAGAAGGT 
GGTGGAAGAG GTACCAATCT TGGGAAAAAG AAGCAACACA TTTGTCATAT ACCAGGATGT 
GGTAAAGTCT ATGGGAAGAC CTCACATCTG AGAGCTCATC TGCGTTGGCA TTCTGGAGAA 
CGCCCTTTTG TTTGTAACTG GATGTACTGT GGTAAAAGAT TTACTCGAAG TGATGAATTA 
CAGAGGCACA GAAGAACACA TACAGGTGAG AAGAAATTTG TTTGTCCAGA ATGTTCAAAA 
CGCTTTATGA GAAGTGACCA CCTTGCCAAA CATATTAAAA CACACCAGAA TAAAAAAGGT 
ATTCACTCTA GCAGTACAGT GCTGGCATCT GTGGAAGCTG CGCGAGATGA TACTTTGATT 
ACTGCAGGAG GAACAACGCT TATCCTTGCA AATATTCAAC AAGGTTCTGT TTCAGGGATA 
GGAACTGTTA ATACTTCCGC CACCAGCAAT CAAGATATCC TTACCAACAC TGAAATACCT 
TTACAGCTTG TCACAGTTTC TGGAAATGAG ACAATGGAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SP3 ( NM_001017371.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_001017371.3 Homo sapiens Sp3 transcription factor (SP3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu13923
Clone ID Related Accession (Same CDS sequence)	NM_001017371.4 , NM_001017371.5
Accession Version	NM_001017371.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2142bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-18
Organism	Homo sapiens(human)
Product	transcription factor Sp3 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY070137.1, M97191.2, AB209334.1, BQ010796.1, AC093399.6 and AC106900.3. On Jun 2, 2019 this sequence version replaced NM_001017371.4. Transcript Variant: This variant (2) is missing exons 1 and 2 found in transcript variant 1, and has a different 5' end. It initiates translation from a non-AUG (AUA) start site, and encodes an isoform (2) with a shorter N-terminus compared to isoform 1. Alternative translation initiation from downstream, in-frame AUG start codons produces shorter isoforms. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.82147.1, SRR1660807.29204.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## non-AUG initiation codon :: PMID: 12297010 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATAGGGCCGC CATCGCCGGG CGACGACGAG GAGGAGGCGG CCGCCGCAGC CGGGGCCCCC 
GCCGCCGCCG GAGCGACAGG TGATTTGGCT TCTGCACAGT TAGGAGGAGC ACCAAACCGA 
TGGGAGGTTT TGTCAGCCAC ACCTACAACT ATAAAAGATG AAGCTGGTAA TCTAGTCCAG 
ATTCCAAGTG CTGCTACTTC AAGTGGGCAG TATGTTCTTC CCCTTCAGAA TTTGCAGAAT 
CAACAAATAT TTTCCGTTGC ACCAGGATCA GATTCATCAA ATGGTACAGT GTCCAGTGTT 
CAATATCAAG TGATACCACA GATCCAGTCA GCAGATGGTC AGCAGGTTCA AATTGGTTTC 
ACAGGCTCTT CAGATAATGG GGGTATAAAT CAAGAAAGCA GTCAAATTCA GATCATTCCT 
GGCTCTAATC AAACCTTACT TGCCTCTGGA ACACCTTCTG CTAACATCCA GAATCTCATA 
CCACAGACTG GTCAAGTCCA GGTTCAGGGA GTTGCAATTG GTGGTTCATC TTTTCCTGGT 
CAAACCCAAG TAGTTGCTAA TGTGCCTCTT GGTCTGCCAG GAAATATTAC GTTTGTACCA 
ATCAATAGTG TCGATCTAGA TTCTTTGGGA CTCTCGGGCA GTTCTCAGAC AATGACTGCA 
GGCATTAATG CCGACGGACA TTTGATAAAC ACAGGACAAG CTATGGATAG TTCAGACAAT 
TCAGAAAGGA CTGGTGAGCG GGTTTCTCCT GATATTAATG AAACTAATAC TGATACAGAT 
TTATTTGTGC CAACATCCTC TTCATCACAG TTGCCTGTTA CGATAGATAG TACAGGTATA 
TTACAACAAA ACACAAATAG CTTGACTACA TCTAGTGGGC AGGTTCATTC TTCAGATCTT 
CAGGGAAATT ATATCCAGTC GCCTGTTTCT GAAGAGACAC AGGCACAGAA TATTCAGGTT 
TCTACAGCAC AGCCTGTTGT ACAGCATCTA CAACTTCAAG AGTCTCAGCA GCCAACCAGT 
CAAGCCCAAA TTGTGCAAGG TATTACACCA CAGACAATCC ATGGTGTGCA AGCCAGTGGT 
CAAAATATAT CACAACAGGC TTTGCAAAAT CTTCAGTTGC AGCTGAATCC TGGAACCTTT 
TTAATTCAGG CACAGACAGT GACCCCTTCT GGACAGGTAA CTTGGCAAAC GTTTCAAGTA 
CAAGGGGTCC AGAACTTGCA GAATTTGCAA ATACAGAATA CTGCTGCCCA ACAAATAACT 
TTGACGCCTG TTCAAACCCT CACACTTGGT CAAGTTGCGG CAGGTGGAGC CTTCACTTCA 
ACTCCAGTTA GTCTAAGCAC TGGTCAGTTG CCAAATCTAC AAACAGTTAC AGTGAACTCT 
ATAGATTCTG CTGGTATACA GCTACATCCA GGAGAGAATG CTGACAGTCC TGCAGATATT 
AGGATCAAGG AAGAAGAACC TGATCCTGAA GAGTGGCAGC TCAGTGGTGA TTCTACCTTG 
AATACCAATG ACCTAACACA CTTAAGAGTA CAGGTGGTAG ATGAAGAAGG GGACCAACAA 
CATCAAGAAG GAAAAAGACT TCGGAGGGTA GCTTGCACCT GTCCCAACTG TAAAGAAGGT 
GGTGGAAGAG GTACCAATCT TGGGAAAAAG AAGCAACACA TTTGTCATAT ACCAGGATGT 
GGTAAAGTCT ATGGGAAGAC CTCACATCTG AGAGCTCATC TGCGTTGGCA TTCTGGAGAA 
CGCCCTTTTG TTTGTAACTG GATGTACTGT GGTAAAAGAT TTACTCGAAG TGATGAATTA 
CAGAGGCACA GAAGAACACA TACAGGTGAG AAGAAATTTG TTTGTCCAGA ATGTTCAAAA 
CGCTTTATGA GAAGTGACCA CCTTGCCAAA CATATTAAAA CACACCAGAA TAAAAAAGGT 
ATTCACTCTA GCAGTACAGT GCTGGCATCT GTGGAAGCTG CGCGAGATGA TACTTTGATT 
ACTGCAGGAG GAACAACGCT TATCCTTGCA AATATTCAAC AAGGTTCTGT TTCAGGGATA 
GGAACTGTTA ATACTTCCGC CACCAGCAAT CAAGATATCC TTACCAACAC TGAAATACCT 
TTACAGCTTG TCACAGTTTC TGGAAATGAG ACAATGGAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001017371.3
CDS	46..2187
Translation	IGPPSPGDDEEEAAAAAGAPAAAGATGDLASAQLGGAPNRWEVLSATPTTIKDEAGNLVQIPSAATSSGQYVLPLQNLQNQQIFSVAPGSDSSNGTVSSVQYQVIPQIQSADGQQVQIGFTGSSDNGGINQESSQIQIIPGSNQTLLASGTPSANIQNLIPQTGQVQVQGVAIGGSSFPGQTQVVANVPLGLPGNITFVPINSVDLDSLGLSGSSQTMTAGINADGHLINTGQAMDSSDNSERTGERVSPDINETNTDTDLFVPTSSSSQLPVTIDSTGILQQNTNSLTTSSGQVHSSDLQGNYIQSPVSEETQAQNIQVSTAQPVVQHLQLQESQQPTSQAQIVQGITPQTIHGVQASGQNISQQALQNLQLQLNPGTFLIQAQTVTPSGQVTWQTFQVQGVQNLQNLQIQNTAAQQITLTPVQTLTLGQVAAGGAFTSTPVSLSTGQLPNLQTVTVNSIDSAGIQLHPGENADSPADIRIKEEEPDPEEWQLSGDSTLNTNDLTHLRVQVVDEEGDQQHQEGKRLRRVACTCPNCKEGGGRGTNLGKKKQHICHIPGCGKVYGKTSHLRAHLRWHSGERPFVCNWMYCGKRFTRSDELQRHRRTHTGEKKFVCPECSKRFMRSDHLAKHIKTHQNKKGIHSSSTVLASVEAARDDTLITAGGTTLILANIQQGSVSGIGTVNTSATSNQDILTNTEIPLQLVTVSGNETME

Target ORF information:

RefSeq Version	NM_001017371.5
Organism	Homo sapiens(human)
Definition	Homo sapiens Sp3 transcription factor (SP3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001017371.5

ORF Insert Sequence:

ATAGGGCCGC CATCGCCGGG CGACGACGAG GAGGAGGCGG CCGCCGCAGC CGGGGCCCCC 
GCCGCCGCCG GAGCGACAGG TGATTTGGCT TCTGCACAGT TAGGAGGAGC ACCAAACCGA 
TGGGAGGTTT TGTCAGCCAC ACCTACAACT ATAAAAGATG AAGCTGGTAA TCTAGTCCAG 
ATTCCAAGTG CTGCTACTTC AAGTGGGCAG TATGTTCTTC CCCTTCAGAA TTTGCAGAAT 
CAACAAATAT TTTCCGTTGC ACCAGGATCA GATTCATCAA ATGGTACAGT GTCCAGTGTT 
CAATATCAAG TGATACCACA GATCCAGTCA GCAGATGGTC AGCAGGTTCA AATTGGTTTC 
ACAGGCTCTT CAGATAATGG GGGTATAAAT CAAGAAAGCA GTCAAATTCA GATCATTCCT 
GGCTCTAATC AAACCTTACT TGCCTCTGGA ACACCTTCTG CTAACATCCA GAATCTCATA 
CCACAGACTG GTCAAGTCCA GGTTCAGGGA GTTGCAATTG GTGGTTCATC TTTTCCTGGT 
CAAACCCAAG TAGTTGCTAA TGTGCCTCTT GGTCTGCCAG GAAATATTAC GTTTGTACCA 
ATCAATAGTG TCGATCTAGA TTCTTTGGGA CTCTCGGGCA GTTCTCAGAC AATGACTGCA 
GGCATTAATG CCGACGGACA TTTGATAAAC ACAGGACAAG CTATGGATAG TTCAGACAAT 
TCAGAAAGGA CTGGTGAGCG GGTTTCTCCT GATATTAATG AAACTAATAC TGATACAGAT 
TTATTTGTGC CAACATCCTC TTCATCACAG TTGCCTGTTA CGATAGATAG TACAGGTATA 
TTACAACAAA ACACAAATAG CTTGACTACA TCTAGTGGGC AGGTTCATTC TTCAGATCTT 
CAGGGAAATT ATATCCAGTC GCCTGTTTCT GAAGAGACAC AGGCACAGAA TATTCAGGTT 
TCTACAGCAC AGCCTGTTGT ACAGCATCTA CAACTTCAAG AGTCTCAGCA GCCAACCAGT 
CAAGCCCAAA TTGTGCAAGG TATTACACCA CAGACAATCC ATGGTGTGCA AGCCAGTGGT 
CAAAATATAT CACAACAGGC TTTGCAAAAT CTTCAGTTGC AGCTGAATCC TGGAACCTTT 
TTAATTCAGG CACAGACAGT GACCCCTTCT GGACAGGTAA CTTGGCAAAC GTTTCAAGTA 
CAAGGGGTCC AGAACTTGCA GAATTTGCAA ATACAGAATA CTGCTGCCCA ACAAATAACT 
TTGACGCCTG TTCAAACCCT CACACTTGGT CAAGTTGCGG CAGGTGGAGC CTTCACTTCA 
ACTCCAGTTA GTCTAAGCAC TGGTCAGTTG CCAAATCTAC AAACAGTTAC AGTGAACTCT 
ATAGATTCTG CTGGTATACA GCTACATCCA GGAGAGAATG CTGACAGTCC TGCAGATATT 
AGGATCAAGG AAGAAGAACC TGATCCTGAA GAGTGGCAGC TCAGTGGTGA TTCTACCTTG 
AATACCAATG ACCTAACACA CTTAAGAGTA CAGGTGGTAG ATGAAGAAGG GGACCAACAA 
CATCAAGAAG GAAAAAGACT TCGGAGGGTA GCTTGCACCT GTCCCAACTG TAAAGAAGGT 
GGTGGAAGAG GTACCAATCT TGGGAAAAAG AAGCAACACA TTTGTCATAT ACCAGGATGT 
GGTAAAGTCT ATGGGAAGAC CTCACATCTG AGAGCTCATC TGCGTTGGCA TTCTGGAGAA 
CGCCCTTTTG TTTGTAACTG GATGTACTGT GGTAAAAGAT TTACTCGAAG TGATGAATTA 
CAGAGGCACA GAAGAACACA TACAGGTGAG AAGAAATTTG TTTGTCCAGA ATGTTCAAAA 
CGCTTTATGA GAAGTGACCA CCTTGCCAAA CATATTAAAA CACACCAGAA TAAAAAAGGT 
ATTCACTCTA GCAGTACAGT GCTGGCATCT GTGGAAGCTG CGCGAGATGA TACTTTGATT 
ACTGCAGGAG GAACAACGCT TATCCTTGCA AATATTCAAC AAGGTTCTGT TTCAGGGATA 
GGAACTGTTA ATACTTCCGC CACCAGCAAT CAAGATATCC TTACCAACAC TGAAATACCT 
TTACAGCTTG TCACAGTTTC TGGAAATGAG ACAATGGAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SP3 ( NM_001172712.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001166183.1 Homo sapiens Sp3 transcription factor (SP3), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu28261
Clone ID Related Accession (Same CDS sequence)	NM_001172712.1
Accession Version	NM_001172712.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2337bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Homo sapiens(human)
Product	transcription factor Sp3 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY441957.1, BC143928.1, M97191.2, AB209334.1 and BQ010796.1. Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1. Alternative translation initiation from downstream, in-frame start codons produces shorter isoforms. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC143928.1, SRR1803614.49757.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## regulatory uORF :: PMID: 15247228 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGACCGCTC CCGAAAAGCC CGTGAAACAA GAGGAAATGG CTGCCTTGGA CGTGGATAGC 
GGCGGCGGCG GTGGCGGCGG CGGCGGCCAC GGCGAGTATC TGCAGCAGCA GCAACAGCAC 
GGAAACGGTG CGGTGGCGGC GGCAGCGGCG GCCCAGCCGT CACCGCTCGC TCTGCTGGCC 
GCTACCTGCA GCAAGATAGG GCCGCCATCG CCGGGCGACG ACGAGGAGGA GGCGGCCGCC 
GCAGCCGGGG CCCCCGCCGC CGCCGGAGCG ACAGGTGATT TGGCTTCTGC ACAGTTAGGA 
GGAGCACCAA ACCGATGGGA GGTTTTGTCA GCCACACCTA CAACTATAAA AGATGAAGCT 
GGTAATCTAG TCCAGATTCC AAGTGCTGCT ACTTCAAGTG GGCAGTATGT TCTTCCCCTT 
CAGAATTTGC AGAATCAACA AATATTTTCC GTTGCACCAG GATCAGATTC ATCAAATGGT 
ACAGTGTCCA GTGTTCAATA TCAAGTGATA CCACAGATCC AGTCAGCAGA TGGTCAGCAG 
GTTCAAATTG GTTTCACAGG CTCTTCAGAT AATGGGGGTA TAAATCAAGA AAGCAGTCAA 
ATTCAGATCA TTCCTGGCTC TAATCAAACC TTACTTGCCT CTGGAACACC TTCTGCTAAC 
ATCCAGAATC TCATACCACA GACTGGTCAA GTCCAGGTTC AGGGAGTTGC AATTGGTGGT 
TCATCTTTTC CTGGTCAAAC CCAAGTAGTT GCTAATGTGC CTCTTGGTCT GCCAGGAAAT 
ATTACGTTTG TACCAATCAA TAGTGTCGAT CTAGATTCTT TGGGACTCTC GGGCAGTTCT 
CAGACAATGA CTGCAGGCAT TAATGCCGAC GGACATTTGA TAAACACAGG ACAAGCTATG 
GATAGTTCAG ACAATTCAGA AAGGACTGGT GAGCGGGTTT CTCCTGATAT TAATGAAACT 
AATACTGATA CAGATTTATT TGTGCCAACA TCCTCTTCAT CACAGTTGCC TGTTACGATA 
GATAGTACAG GTATATTACA ACAAAACACA AATAGCTTGA CTACATCTAG TGGGCAGGTT 
CATTCTTCAG ATCTTCAGGG AAATTATATC CAGTCGCCTG TTTCTGAAGA GACACAGGCA 
CAGAATATTC AGGTTTCTAC AGCACAGCCT GTTGTACAGC ATCTACAACT TCAAGAGTCT 
CAGCAGCCAA CCAGTCAAGC CCAAATTGTG CAAGGTATTA CACCACAGAC AATCCATGGT 
GTGCAAGCCA GTGGTCAAAA TATATCACAA CAGGCTTTGC AAAATCTTCA GTTGCAGCTG 
AATCCTGGAA CCTTTTTAAT TCAGGCACAG ACAGTGACCC CTTCTGGACA GGTAACTTGG 
CAAACGTTTC AAGTACAAGG GGTCCAGAAC TTGCAGAATT TGCAAATACA GAATACTGCT 
GCCCAACAAA TAACTTTGAC GCCTGTTCAA ACCCTCACAC TTGGTCAAGT TGCGGCAGGT 
GGAGCCTTCA CTTCAACTCC AGTTAGTCTA AGCACTGGTC AGTTGCCAAA TCTACAAACA 
GTTACAGTGA ACTCTATAGA TTCTGCTGGT ATACAGCTAC ATCCAGGAGA GAATGCTGAC 
AGTCCTGCAG ATATTAGGAT CAAGGAAGAA GAACCTGATC CTGAAGAGTG GCAGCTCAGT 
GGTGATTCTA CCTTGAATAC CAATGACCTA ACACACTTAA GAGTACAGGT GGTAGATGAA 
GAAGGGGACC AACAACATCA AGAAGGAAAA AGACTTCGGA GGGTAGCTTG CACCTGTCCC 
AACTGTAAAG AAGGTGGTGG AAGAGGTACC AATCTTGGGA AAAAGAAGCA ACACATTTGT 
CATATACCAG GATGTGGTAA AGTCTATGGG AAGACCTCAC ATCTGAGAGC TCATCTGCGT 
TGGCATTCTG GAGAACGCCC TTTTGTTTGT AACTGGATGT ACTGTGGTAA AAGATTTACT 
CGAAGTGATG AATTACAGAG GCACAGAAGA ACACATACAG GTGAGAAGAA ATTTGTTTGT 
CCAGAATGTT CAAAACGCTT TATGAGAAGT GACCACCTTG CCAAACATAT TAAAACACAC 
CAGAATAAAA AAGGTATTCA CTCTAGCAGT ACAGTGCTGG CATCTGTGGA AGCTGCGCGA 
GATGATACTT TGATTACTGC AGGAGGAACA ACGCTTATCC TTGCAAATAT TCAACAAGGT 
TCTGTTTCAG GGATAGGAAC TGTTAATACT TCCGCCACCA GCAATCAAGA TATCCTTACC 
AACACTGAAA TACCTTTACA GCTTGTCACA GTTTCTGGAA ATGAGACAAT GGAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001166183.1
CDS	532..2868
Translation	MTAPEKPVKQEEMAALDVDSGGGGGGGGGHGEYLQQQQQHGNGAVAAAAAAQPSPLALLAATCSKIGPPSPGDDEEEAAAAAGAPAAAGATGDLASAQLGGAPNRWEVLSATPTTIKDEAGNLVQIPSAATSSGQYVLPLQNLQNQQIFSVAPGSDSSNGTVSSVQYQVIPQIQSADGQQVQIGFTGSSDNGGINQESSQIQIIPGSNQTLLASGTPSANIQNLIPQTGQVQVQGVAIGGSSFPGQTQVVANVPLGLPGNITFVPINSVDLDSLGLSGSSQTMTAGINADGHLINTGQAMDSSDNSERTGERVSPDINETNTDTDLFVPTSSSSQLPVTIDSTGILQQNTNSLTTSSGQVHSSDLQGNYIQSPVSEETQAQNIQVSTAQPVVQHLQLQESQQPTSQAQIVQGITPQTIHGVQASGQNISQQALQNLQLQLNPGTFLIQAQTVTPSGQVTWQTFQVQGVQNLQNLQIQNTAAQQITLTPVQTLTLGQVAAGGAFTSTPVSLSTGQLPNLQTVTVNSIDSAGIQLHPGENADSPADIRIKEEEPDPEEWQLSGDSTLNTNDLTHLRVQVVDEEGDQQHQEGKRLRRVACTCPNCKEGGGRGTNLGKKKQHICHIPGCGKVYGKTSHLRAHLRWHSGERPFVCNWMYCGKRFTRSDELQRHRRTHTGEKKFVCPECSKRFMRSDHLAKHIKTHQNKKGIHSSSTVLASVEAARDDTLITAGGTTLILANIQQGSVSGIGTVNTSATSNQDILTNTEIPLQLVTVSGNETME

Target ORF information:

RefSeq Version	NM_001172712.1
Organism	Homo sapiens(human)
Definition	Homo sapiens Sp3 transcription factor (SP3), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001172712.1

ORF Insert Sequence:

ATGACCGCTC CCGAAAAGCC CGTGAAACAA GAGGAAATGG CTGCCTTGGA CGTGGATAGC 
GGCGGCGGCG GTGGCGGCGG CGGCGGCCAC GGCGAGTATC TGCAGCAGCA GCAACAGCAC 
GGAAACGGTG CGGTGGCGGC GGCAGCGGCG GCCCAGCCGT CACCGCTCGC TCTGCTGGCC 
GCTACCTGCA GCAAGATAGG GCCGCCATCG CCGGGCGACG ACGAGGAGGA GGCGGCCGCC 
GCAGCCGGGG CCCCCGCCGC CGCCGGAGCG ACAGGTGATT TGGCTTCTGC ACAGTTAGGA 
GGAGCACCAA ACCGATGGGA GGTTTTGTCA GCCACACCTA CAACTATAAA AGATGAAGCT 
GGTAATCTAG TCCAGATTCC AAGTGCTGCT ACTTCAAGTG GGCAGTATGT TCTTCCCCTT 
CAGAATTTGC AGAATCAACA AATATTTTCC GTTGCACCAG GATCAGATTC ATCAAATGGT 
ACAGTGTCCA GTGTTCAATA TCAAGTGATA CCACAGATCC AGTCAGCAGA TGGTCAGCAG 
GTTCAAATTG GTTTCACAGG CTCTTCAGAT AATGGGGGTA TAAATCAAGA AAGCAGTCAA 
ATTCAGATCA TTCCTGGCTC TAATCAAACC TTACTTGCCT CTGGAACACC TTCTGCTAAC 
ATCCAGAATC TCATACCACA GACTGGTCAA GTCCAGGTTC AGGGAGTTGC AATTGGTGGT 
TCATCTTTTC CTGGTCAAAC CCAAGTAGTT GCTAATGTGC CTCTTGGTCT GCCAGGAAAT 
ATTACGTTTG TACCAATCAA TAGTGTCGAT CTAGATTCTT TGGGACTCTC GGGCAGTTCT 
CAGACAATGA CTGCAGGCAT TAATGCCGAC GGACATTTGA TAAACACAGG ACAAGCTATG 
GATAGTTCAG ACAATTCAGA AAGGACTGGT GAGCGGGTTT CTCCTGATAT TAATGAAACT 
AATACTGATA CAGATTTATT TGTGCCAACA TCCTCTTCAT CACAGTTGCC TGTTACGATA 
GATAGTACAG GTATATTACA ACAAAACACA AATAGCTTGA CTACATCTAG TGGGCAGGTT 
CATTCTTCAG ATCTTCAGGG AAATTATATC CAGTCGCCTG TTTCTGAAGA GACACAGGCA 
CAGAATATTC AGGTTTCTAC AGCACAGCCT GTTGTACAGC ATCTACAACT TCAAGAGTCT 
CAGCAGCCAA CCAGTCAAGC CCAAATTGTG CAAGGTATTA CACCACAGAC AATCCATGGT 
GTGCAAGCCA GTGGTCAAAA TATATCACAA CAGGCTTTGC AAAATCTTCA GTTGCAGCTG 
AATCCTGGAA CCTTTTTAAT TCAGGCACAG ACAGTGACCC CTTCTGGACA GGTAACTTGG 
CAAACGTTTC AAGTACAAGG GGTCCAGAAC TTGCAGAATT TGCAAATACA GAATACTGCT 
GCCCAACAAA TAACTTTGAC GCCTGTTCAA ACCCTCACAC TTGGTCAAGT TGCGGCAGGT 
GGAGCCTTCA CTTCAACTCC AGTTAGTCTA AGCACTGGTC AGTTGCCAAA TCTACAAACA 
GTTACAGTGA ACTCTATAGA TTCTGCTGGT ATACAGCTAC ATCCAGGAGA GAATGCTGAC 
AGTCCTGCAG ATATTAGGAT CAAGGAAGAA GAACCTGATC CTGAAGAGTG GCAGCTCAGT 
GGTGATTCTA CCTTGAATAC CAATGACCTA ACACACTTAA GAGTACAGGT GGTAGATGAA 
GAAGGGGACC AACAACATCA AGAAGGAAAA AGACTTCGGA GGGTAGCTTG CACCTGTCCC 
AACTGTAAAG AAGGTGGTGG AAGAGGTACC AATCTTGGGA AAAAGAAGCA ACACATTTGT 
CATATACCAG GATGTGGTAA AGTCTATGGG AAGACCTCAC ATCTGAGAGC TCATCTGCGT 
TGGCATTCTG GAGAACGCCC TTTTGTTTGT AACTGGATGT ACTGTGGTAA AAGATTTACT 
CGAAGTGATG AATTACAGAG GCACAGAAGA ACACATACAG GTGAGAAGAA ATTTGTTTGT 
CCAGAATGTT CAAAACGCTT TATGAGAAGT GACCACCTTG CCAAACATAT TAAAACACAC 
CAGAATAAAA AAGGTATTCA CTCTAGCAGT ACAGTGCTGG CATCTGTGGA AGCTGCGCGA 
GATGATACTT TGATTACTGC AGGAGGAACA ACGCTTATCC TTGCAAATAT TCAACAAGGT 
TCTGTTTCAG GGATAGGAAC TGTTAATACT TCCGCCACCA GCAATCAAGA TATCCTTACC 
AACACTGAAA TACCTTTACA GCTTGTCACA GTTTCTGGAA ATGAGACAAT GGAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A type 2 diabetes-associated SNP in KCNQ1 (rs163184) modulates the binding activity of the locus for Sp3 and Lsd1/Kdm1a, potentially affecting CDKN1C expression.
International journal of molecular medicine41(2)717-728(2018 Feb)
Hiramoto M,Udagawa H,Ishibashi N,Takahashi E,Kaburagi Y,Miyazawa K,Funahashi N,Nammo T,Yasuda K

The miR-491-3p/Sp3/ABCB1 axis attenuates multidrug resistance of hepatocellular carcinoma.
Cancer letters408102-111(2017 Nov)
Zhao Y,Qi X,Chen J,Wei W,Yu C,Yan H,Pu M,Li Y,Miao L,Li C,Ren J

Minimal essential region for kr?ppel-like factor 5 expression and the regulation by specificity protein 3-GC box binding.
Gene60136-43(2017 Feb)
Mihara N,Chiba T,Yamaguchi K,Sudo H,Yagishita H,Imai K

Trefoil factor family 2 expression inhibits gastric cancer cell growth and invasion in?vitro via interactions with the transcription factor Sp3.
International journal of molecular medicine38(5)1474-1480(2016 Nov)
Cai Y,Yi M,Chen D,Liu J,Guleng B,Ren J,Shi H

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

SP3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報