SOX3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SOX3
Entrez Gene ID	6658
Full Name	SRY-box 3
Synonyms	GHDX,MRGH,PHP,PHPX,SOXB
General protein information	Preferred Names SRY-box 3 Names transcription factor SOX-3 SRY (sex determining region Y)-box 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq27.1
Summary	This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. Mutations in this gene have been associated with X-linked cognitive disability with growth hormone deficiency. [provided by RefSeq, Jul 2008].
Disorder MIM:	313430
Disorder Html:	Mental retardation, X-linked, with isolated growth hormone deficiency, 300123 (3); Panhypopituitarism, X-linked, 312000 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_005634.2	NP_005625.2	transcription factor SOX-3

Pathways from BioSystems

Homologies

	SOX3	XP_001085170.1
Mus musculus (house mouse)	Sox3	NP_033263.2
Gallus gallus (chicken)	SOX3	NP_989526.1
Homo sapiens (human)	SOX3	NP_005625.2
Canis lupus familiaris (dog)	SOX3	XP_852934.1
Danio rerio (zebrafish)	sox3	NP_001001811.2
Xenopus tropicalis (tropical clawed frog)	sox3	NP_001007502.1

Gene Ontology
Bibliography

Related articles in PubMed

A complex phenotype in a family with a pathogenic SOX3 missense variant.
Jelsig AM, Diness BR, Kreiborg S, Main KM, Larsen VA, Hove H
European journal of medical genetics(2017 Nov)

Epigenetic regulation of human SOX3 gene expression during early phases of neural differentiation of NT2/D1 cells.
Topalovic V, Krstic A, Schwirtlich M, Dolfini D, Mantovani R, Stevanovic M, Mojsin M
PloS one12(9)e0184099(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These findings demonstrate the novel mechanism by which Sox3 contributes to endometrial cancer stem cell invasion and suggest that repression of Sox3 by microRNA-194 may have therapeutic potential to suppress endometrial carcinoma metastasis. The cancer stem cell marker, CD133, might be the surface marker of endometrial cancer stem cell.
Title: Overexpression of microRNA-194 suppresses the epithelial-mesenchymal transition in targeting stem cell transcription factor Sox3 in endometrial carcinoma stem cells.

Results show that SOX3 is upregulated in human osteosarcoma (OS) tissues and provide evidence that SOX3 promotes migration, invasiveness, and EMT in OS cells via transcriptional activation of Snail1 expression.
Title: Sex-determining region Y-box protein 3 induces epithelial-mesenchymal transition in osteosarcoma cells via transcriptional activation of Snail1.

we provide a first map of the epigenetic landscape of SOX3 in pluripotent cells and during the early phases of neural differentiation. We found SOX3 gene to be non methylated from undifferentiated NT2/D1 to cells committed towards neural lineage.
Title: Epigenetic regulation of human SOX3 gene expression during early phases of neural differentiation of NT2/D1 cells.

deletion of the SOX3 gene may have a role in intellectual disability with hemophilia B
Title: Study of six patients with complete F9 deletion characterized by cytogenetic microarray: role of the SOX3 gene in intellectual disability.

Data indicate that SRY-box 3 transcription factor SOX-3 targets Src kinase in epithelial ovarian cancer (EOC) cells.
Title: Sex-determining region Y-box3 (SOX3) functions as an oncogene in promoting epithelial ovarian cancer by targeting Src kinase.

The following SOX3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SOX3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu19634	NM_005634.2 Latest version!	Homo sapiens SRY-box transcription factor 3 (SOX3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SOX3 ( NM_005634.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_005625.2 Homo sapiens SRY-box transcription factor 3 (SOX3), mRNA.

Price & Availability↑

CloneID	OHu19634
Clone ID Related Accession (Same CDS sequence)	NM_005634.2
Accession Version	NM_005634.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1341bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	transcription factor SOX-3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X71135.1. This sequence is a reference standard in the RefSeqGene project. On Apr 23, 2003 this sequence version replaced NM_005634.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCGACCTG TTCGAGAGAA CTCATCAGGT GCGAGAAGCC CGCGGGTTCC TGCTGATTTG 
GCGCGGAGCA TTTTGATAAG CCTACCCTTC CCGCCGGACT CGCTGGCCCA CAGGCCCCCA 
AGCTCCGCTC CGACGGAGTC CCAGGGCCTT TTCACCGTGG CCGCTCCAGC CCCGGGAGCG 
CCTTCTCCTC CCGCCACGCT GGCGCACCTT CTTCCCGCCC CGGCAATGTA CAGCCTTCTG 
GAGACTGAAC TCAAGAACCC CGTAGGGACA CCCACACAAG CGGCGGGCAC CGGCGGCCCC 
GCAGCCCCGG GAGGCGCAGG CAAGAGTAGT GCGAACGCAG CCGGCGGCGC GAACTCGGGC 
GGCGGCAGCA GCGGTGGTGC GAGCGGAGGT GGCGGGGGTA CAGACCAGGA CCGTGTGAAA 
CGGCCCATGA ACGCCTTCAT GGTATGGTCC CGCGGGCAGC GGCGCAAAAT GGCCCTGGAG 
AACCCCAAGA TGCACAATTC TGAGATCAGC AAGCGCTTGG GCGCCGACTG GAAACTGCTG 
ACCGACGCCG AGAAGCGACC ATTCATCGAC GAGGCCAAGC GACTTCGCGC CGTGCACATG 
AAGGAGTATC CGGACTACAA GTACCGACCG CGCCGCAAGA CCAAGACGCT GCTCAAGAAA 
GATAAGTACT CCCTGCCCAG CGGCCTCCTG CCTCCCGGTG CCGCGGCCGC CGCCGCCGCT 
GCCGCGGCCG CAGCCGCTGC CGCCAGCAGT CCGGTGGGCG TGGGCCAGCG CCTGGACACG 
TACACGCACG TGAACGGCTG GGCCAACGGC GCGTACTCGC TGGTGCAGGA GCAGCTGGGC 
TACGCGCAGC CCCCGAGCAT GAGCAGCCCG CCGCCGCCGC CCGCGCTGCC GCCGATGCAC 
CGCTACGACA TGGCCGGCCT GCAGTACAGC CCAATGATGC CGCCCGGCGC TCAGAGCTAC 
ATGAACGTCG CTGCCGCGGC CGCCGCCGCC TCGGGCTACG GGGGCATGGC GCCCTCAGCC 
ACAGCAGCCG CGGCCGCCGC CTACGGGCAG CAGCCCGCCA CCGCCGCGGC CGCAGCTGCG 
GCCGCAGCCG CCATGAGCCT GGGCCCCATG GGCTCGGTAG TGAAGTCTGA GCCCAGCTCG 
CCGCCGCCCG CCATCGCATC GCACTCTCAG CGCGCGTGCC TCGGCGACCT GCGCGACATG 
ATCAGCATGT ACCTGCCACC CGGCGGGGAC GCGGCCGACG CCGCCTCTCC GCTGCCCGGC 
GGTCGCCTGC ACGGCGTGCA CCAGCACTAC CAGGGCGCCG GGACTGCAGT CAACGGAACG 
GTGCCGCTGA CCCACATCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005625.2
CDS	1..1341
Translation	MRPVRENSSGARSPRVPADLARSILISLPFPPDSLAHRPPSSAPTESQGLFTVAAPAPGAPSPPATLAHLLPAPAMYSLLETELKNPVGTPTQAAGTGGPAAPGGAGKSSANAAGGANSGGGSSGGASGGGGGTDQDRVKRPMNAFMVWSRGQRRKMALENPKMHNSEISKRLGADWKLLTDAEKRPFIDEAKRLRAVHMKEYPDYKYRPRRKTKTLLKKDKYSLPSGLLPPGAAAAAAAAAAAAAAASSPVGVGQRLDTYTHVNGWANGAYSLVQEQLGYAQPPSMSSPPPPPALPPMHRYDMAGLQYSPMMPPGAQSYMNVAAAAAAASGYGGMAPSATAAAAAAYGQQPATAAAAAAAAAAMSLGPMGSVVKSEPSSPPPAIASHSQRACLGDLRDMISMYLPPGGDAADAASPLPGGRLHGVHQHYQGAGTAVNGTVPLTHI

Target ORF information:

RefSeq Version	NM_005634.2
Organism	Homo sapiens(human)
Definition	Homo sapiens SRY-box transcription factor 3 (SOX3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005634.2

ORF Insert Sequence:

ATGCGACCTG TTCGAGAGAA CTCATCAGGT GCGAGAAGCC CGCGGGTTCC TGCTGATTTG 
GCGCGGAGCA TTTTGATAAG CCTACCCTTC CCGCCGGACT CGCTGGCCCA CAGGCCCCCA 
AGCTCCGCTC CGACGGAGTC CCAGGGCCTT TTCACCGTGG CCGCTCCAGC CCCGGGAGCG 
CCTTCTCCTC CCGCCACGCT GGCGCACCTT CTTCCCGCCC CGGCAATGTA CAGCCTTCTG 
GAGACTGAAC TCAAGAACCC CGTAGGGACA CCCACACAAG CGGCGGGCAC CGGCGGCCCC 
GCAGCCCCGG GAGGCGCAGG CAAGAGTAGT GCGAACGCAG CCGGCGGCGC GAACTCGGGC 
GGCGGCAGCA GCGGTGGTGC GAGCGGAGGT GGCGGGGGTA CAGACCAGGA CCGTGTGAAA 
CGGCCCATGA ACGCCTTCAT GGTATGGTCC CGCGGGCAGC GGCGCAAAAT GGCCCTGGAG 
AACCCCAAGA TGCACAATTC TGAGATCAGC AAGCGCTTGG GCGCCGACTG GAAACTGCTG 
ACCGACGCCG AGAAGCGACC ATTCATCGAC GAGGCCAAGC GACTTCGCGC CGTGCACATG 
AAGGAGTATC CGGACTACAA GTACCGACCG CGCCGCAAGA CCAAGACGCT GCTCAAGAAA 
GATAAGTACT CCCTGCCCAG CGGCCTCCTG CCTCCCGGTG CCGCGGCCGC CGCCGCCGCT 
GCCGCGGCCG CAGCCGCTGC CGCCAGCAGT CCGGTGGGCG TGGGCCAGCG CCTGGACACG 
TACACGCACG TGAACGGCTG GGCCAACGGC GCGTACTCGC TGGTGCAGGA GCAGCTGGGC 
TACGCGCAGC CCCCGAGCAT GAGCAGCCCG CCGCCGCCGC CCGCGCTGCC GCCGATGCAC 
CGCTACGACA TGGCCGGCCT GCAGTACAGC CCAATGATGC CGCCCGGCGC TCAGAGCTAC 
ATGAACGTCG CTGCCGCGGC CGCCGCCGCC TCGGGCTACG GGGGCATGGC GCCCTCAGCC 
ACAGCAGCCG CGGCCGCCGC CTACGGGCAG CAGCCCGCCA CCGCCGCGGC CGCAGCTGCG 
GCCGCAGCCG CCATGAGCCT GGGCCCCATG GGCTCGGTAG TGAAGTCTGA GCCCAGCTCG 
CCGCCGCCCG CCATCGCATC GCACTCTCAG CGCGCGTGCC TCGGCGACCT GCGCGACATG 
ATCAGCATGT ACCTGCCACC CGGCGGGGAC GCGGCCGACG CCGCCTCTCC GCTGCCCGGC 
GGTCGCCTGC ACGGCGTGCA CCAGCACTAC CAGGGCGCCG GGACTGCAGT CAACGGAACG 
GTGCCGCTGA CCCACATCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A complex phenotype in a family with a pathogenic SOX3 missense variant.
European journal of medical genetics(2017 Nov)
Jelsig AM,Diness BR,Kreiborg S,Main KM,Larsen VA,Hove H

Epigenetic regulation of human SOX3 gene expression during early phases of neural differentiation of NT2/D1 cells.
PloS one12(9)e0184099(2017)
Topalovic V,Krstic A,Schwirtlich M,Dolfini D,Mantovani R,Stevanovic M,Mojsin M

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SOX3 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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