SNRPD3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SNRPD3
Entrez Gene ID	6634
Full Name	small nuclear ribonucleoprotein D3 polypeptide
Synonyms	SMD3,Sm-D3
General protein information	Preferred Names small nuclear ribonucleoprotein D3 polypeptide Names small nuclear ribonucleoprotein Sm D3 small nuclear ribonucleoprotein D3 polypeptide 18kDa snRNP core protein D3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 22 Map Location: 22q11.23
Summary	This gene encodes a core component of the spliceosome, which is a nuclear ribonucleoprotein complex that functions in pre-mRNA splicing. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
Disorder MIM:	601062

mRNA and Protein(s)

mRNA	Protein	Name
NM_004175.5	NP_004166.1	small nuclear ribonucleoprotein Sm D3
NM_004175.4	NP_004166.1	small nuclear ribonucleoprotein Sm D3
NM_001278656.1	NP_001265585.1	small nuclear ribonucleoprotein Sm D3

Pathways from BioSystems

Homologies

Homo sapiens (human)	SNRPD3	NP_001265585.1
	SNRPD3	XP_001096291.1
Canis lupus familiaris (dog)	SNRPD3	XP_849660.1
Bos taurus (cattle)	SNRPD3	NP_001069947.1
Pan troglodytes (chimpanzee)	SNRPD3	XP_003953897.1
Caenorhabditis elegans (roundworm)	snr-1	NP_503027.1
Magnaporthe oryzae (rice blast fungus)	MGG_04083	XP_003719755.1
Xenopus tropicalis (tropical clawed frog)	snrpd3	NP_001017093.1
Mus musculus (house mouse)	Snrpd3	NP_080371.1
Danio rerio (zebrafish)	snrpd3	NP_001002081.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012380	XP_320178.2
Arabidopsis thaliana (thale cress)	AT1G20580	NP_564119.1
Drosophila melanogaster (fruit fly)	SmD3	NP_725106.1
Eremothecium gossypii	AGOS_AGL157C	NP_986510.1
Neurospora crassa	NCU03625	XP_961352.1
Arabidopsis thaliana (thale cress)	SmD3	NP_177757.1
Oryza sativa (rice)	Os02g0102700	NP_001045599.1
Rattus norvegicus (Norway rat)	Snrpd3	XP_003751996.1
Gallus gallus (chicken)	SNRPD3	NP_001007839.1
Schizosaccharomyces pombe (fission yeast)	smd3	NP_595699.1
Oryza sativa (rice)	Os03g0240800	NP_001049511.1

Gene Ontology
Bibliography

Related articles in PubMed

Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.
Bertram K, Agafonov DE, Dybkov O, Haselbach D, Leelaram MN, Will CL, Urlaub H, Kastner B, L?hrmann R, Stark H
Cell170(4)701-713.e11(2017 Aug)

Cryo-EM structure of a human spliceosome activated for step 2 of splicing.
Bertram K, Agafonov DE, Liu WT, Dybkov O, Will CL, Hartmuth K, Urlaub H, Kastner B, Stark H, L?hrmann R
Nature542(7641)318-323(2017 02)

Molecular architecture of the human U4/U6.U5 tri-snRNP.
Agafonov DE, Kastner B, Dybkov O, Hofele RV, Liu WT, Urlaub H, L?hrmann R, Stark H
Science (New York, N.Y.)351(6280)1416-20(2016 Mar)

Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5' splice site recognition.
Kondo Y, Oubridge C, van Roon AM, Nagai K
eLife4(2015 Jan)

Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
Navarini AA, Simpson MA, Weale M, Knight J, Carlavan I, Reiniche P, Burden DA, Layton A, Bataille V, Allen M, Pleass R, Pink A, Creamer D, English J, Munn S, Walton S, , Willis C, D?ret S, Voegel JJ, Spector T, Smith CH, Trembath RC, Barker JN
Nature communications54020(2014 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The dimethylated arginine residues play an essential role in the formation of major SmD3 autoepitopes. 1 particular peptide of SmD3 represents a more sensitive and more reliable substrate for the detection of a subclass of anti-Sm antibodies.
Title: Identification of a SmD3 epitope with a single symmetrical dimethylation of an arginine residue as a specific target of a subpopulation of anti-Sm antibodies.

The following SNRPD3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SNRPD3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu11399	NM_004175.5 Latest version!	Homo sapiens small nuclear ribonucleoprotein D3 polypeptide (SNRPD3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu11399	NM_001278656.1 Latest version!	Homo sapiens small nuclear ribonucleoprotein D3 polypeptide (SNRPD3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu11399	NM_004175.4	Homo sapiens small nuclear ribonucleoprotein D3 polypeptide (SNRPD3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SNRPD3 ( NM_004175.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_004166.1 Homo sapiens small nuclear ribonucleoprotein D3 polypeptide (SNRPD3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu11399
Clone ID Related Accession (Same CDS sequence)	NM_004175.5 , NM_004175.4 , NM_001278656.1
Accession Version	NM_004175.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 381bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-05
Organism	Homo sapiens(human)
Product	small nuclear ribonucleoprotein Sm D3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC000457.2, CN286602.1 and AP000356.1. On Nov 23, 2018 this sequence version replaced NM_004175.4. Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.12982.1, SRR1803615.212856.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000215829.8/ ENSP00000215829.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCTATTG GTGTGCCGAT TAAAGTACTG CATGAGGCCG AGGGCCACAT TGTGACATGT 
GAGACGAACA CCGGTGAGGT ATATCGGGGG AAGCTCATTG AAGCAGAGGA CAACATGAAC 
TGCCAGATGT CCAACATCAC AGTCACATAC AGAGATGGCC GAGTGGCACA GCTGGAGCAG 
GTATACATCC GTGGCAGCAA AATCCGCTTT CTGATTTTGC CTGACATGCT GAAGAACGCA 
CCCATGTTAA AGAGCATGAA AAATAAAAAC CAAGGCTCAG GGGCTGGCCG AGGAAAAGCT 
GCTATTCTCA AGGCCCAAGT GGCCGCAAGA GGAAGAGGAC GTGGAATGGG ACGTGGAAAC 
ATCTTTCAAA AGCGAAGATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004166.1
CDS	92..472
Translation	MSIGVPIKVLHEAEGHIVTCETNTGEVYRGKLIEAEDNMNCQMSNITVTYRDGRVAQLEQVYIRGSKIRFLILPDMLKNAPMLKSMKNKNQGSGAGRGKAAILKAQVAARGRGRGMGRGNIFQKRR

Target ORF information:

RefSeq Version	NM_004175.5
Organism	Homo sapiens(human)
Definition	Homo sapiens small nuclear ribonucleoprotein D3 polypeptide (SNRPD3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004175.5

ORF Insert Sequence:

ATGTCTATTG GTGTGCCGAT TAAAGTACTG CATGAGGCCG AGGGCCACAT TGTGACATGT 
GAGACGAACA CCGGTGAGGT ATATCGGGGG AAGCTCATTG AAGCAGAGGA CAACATGAAC 
TGCCAGATGT CCAACATCAC AGTCACATAC AGAGATGGCC GAGTGGCACA GCTGGAGCAG 
GTATACATCC GTGGCAGCAA AATCCGCTTT CTGATTTTGC CTGACATGCT GAAGAACGCA 
CCCATGTTAA AGAGCATGAA AAATAAAAAC CAAGGCTCAG GGGCTGGCCG AGGAAAAGCT 
GCTATTCTCA AGGCCCAAGT GGCCGCAAGA GGAAGAGGAC GTGGAATGGG ACGTGGAAAC 
ATCTTTCAAA AGCGAAGATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SNRPD3 ( NM_004175.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004166.1 Homo sapiens small nuclear ribonucleoprotein D3 polypeptide (SNRPD3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu11399
Clone ID Related Accession (Same CDS sequence)	NM_004175.5 , NM_004175.4 , NM_001278656.1
Accession Version	NM_004175.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 381bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	small nuclear ribonucleoprotein Sm D3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP000356.1, BC000457.2 and CN286602.1. On Jul 6, 2013 this sequence version replaced NM_004175.3. Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.212856.1, SRR1803613.246654.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCTATTG GTGTGCCGAT TAAAGTACTG CATGAGGCCG AGGGCCACAT TGTGACATGT 
GAGACGAACA CCGGTGAGGT ATATCGGGGG AAGCTCATTG AAGCAGAGGA CAACATGAAC 
TGCCAGATGT CCAACATCAC AGTCACATAC AGAGATGGCC GAGTGGCACA GCTGGAGCAG 
GTATACATCC GTGGCAGCAA AATCCGCTTT CTGATTTTGC CTGACATGCT GAAGAACGCA 
CCCATGTTAA AGAGCATGAA AAATAAAAAC CAAGGCTCAG GGGCTGGCCG AGGAAAAGCT 
GCTATTCTCA AGGCCCAAGT GGCCGCAAGA GGAAGAGGAC GTGGAATGGG ACGTGGAAAC 
ATCTTTCAAA AGCGAAGATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004166.1
CDS	441..821
Translation	MSIGVPIKVLHEAEGHIVTCETNTGEVYRGKLIEAEDNMNCQMSNITVTYRDGRVAQLEQVYIRGSKIRFLILPDMLKNAPMLKSMKNKNQGSGAGRGKAAILKAQVAARGRGRGMGRGNIFQKRR

Target ORF information:

RefSeq Version	NM_004175.4
Organism	Homo sapiens(human)
Definition	Homo sapiens small nuclear ribonucleoprotein D3 polypeptide (SNRPD3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004175.4

ORF Insert Sequence:

ATGTCTATTG GTGTGCCGAT TAAAGTACTG CATGAGGCCG AGGGCCACAT TGTGACATGT 
GAGACGAACA CCGGTGAGGT ATATCGGGGG AAGCTCATTG AAGCAGAGGA CAACATGAAC 
TGCCAGATGT CCAACATCAC AGTCACATAC AGAGATGGCC GAGTGGCACA GCTGGAGCAG 
GTATACATCC GTGGCAGCAA AATCCGCTTT CTGATTTTGC CTGACATGCT GAAGAACGCA 
CCCATGTTAA AGAGCATGAA AAATAAAAAC CAAGGCTCAG GGGCTGGCCG AGGAAAAGCT 
GCTATTCTCA AGGCCCAAGT GGCCGCAAGA GGAAGAGGAC GTGGAATGGG ACGTGGAAAC 
ATCTTTCAAA AGCGAAGATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SNRPD3 ( NM_001278656.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001265585.1 Homo sapiens small nuclear ribonucleoprotein D3 polypeptide (SNRPD3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu11399
Clone ID Related Accession (Same CDS sequence)	NM_004175.5 , NM_004175.4 , NM_001278656.1
Accession Version	NM_001278656.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 381bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-05
Organism	Homo sapiens(human)
Product	small nuclear ribonucleoprotein Sm D3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP000356.1, BY993733.1 and CN286602.1. Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.11132.1, BU176035.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCTATTG GTGTGCCGAT TAAAGTACTG CATGAGGCCG AGGGCCACAT TGTGACATGT 
GAGACGAACA CCGGTGAGGT ATATCGGGGG AAGCTCATTG AAGCAGAGGA CAACATGAAC 
TGCCAGATGT CCAACATCAC AGTCACATAC AGAGATGGCC GAGTGGCACA GCTGGAGCAG 
GTATACATCC GTGGCAGCAA AATCCGCTTT CTGATTTTGC CTGACATGCT GAAGAACGCA 
CCCATGTTAA AGAGCATGAA AAATAAAAAC CAAGGCTCAG GGGCTGGCCG AGGAAAAGCT 
GCTATTCTCA AGGCCCAAGT GGCCGCAAGA GGAAGAGGAC GTGGAATGGG ACGTGGAAAC 
ATCTTTCAAA AGCGAAGATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001265585.1
CDS	427..807
Translation	MSIGVPIKVLHEAEGHIVTCETNTGEVYRGKLIEAEDNMNCQMSNITVTYRDGRVAQLEQVYIRGSKIRFLILPDMLKNAPMLKSMKNKNQGSGAGRGKAAILKAQVAARGRGRGMGRGNIFQKRR

Target ORF information:

RefSeq Version	NM_001278656.1
Organism	Homo sapiens(human)
Definition	Homo sapiens small nuclear ribonucleoprotein D3 polypeptide (SNRPD3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001278656.1

ORF Insert Sequence:

ATGTCTATTG GTGTGCCGAT TAAAGTACTG CATGAGGCCG AGGGCCACAT TGTGACATGT 
GAGACGAACA CCGGTGAGGT ATATCGGGGG AAGCTCATTG AAGCAGAGGA CAACATGAAC 
TGCCAGATGT CCAACATCAC AGTCACATAC AGAGATGGCC GAGTGGCACA GCTGGAGCAG 
GTATACATCC GTGGCAGCAA AATCCGCTTT CTGATTTTGC CTGACATGCT GAAGAACGCA 
CCCATGTTAA AGAGCATGAA AAATAAAAAC CAAGGCTCAG GGGCTGGCCG AGGAAAAGCT 
GCTATTCTCA AGGCCCAAGT GGCCGCAAGA GGAAGAGGAC GTGGAATGGG ACGTGGAAAC 
ATCTTTCAAA AGCGAAGATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.
Cell170(4)701-713.e11(2017 Aug)
Bertram K,Agafonov DE,Dybkov O,Haselbach D,Leelaram MN,Will CL,Urlaub H,Kastner B,L?hrmann R,Stark H

Cryo-EM structure of a human spliceosome activated for step 2 of splicing.
Nature542(7641)318-323(2017 02)
Bertram K,Agafonov DE,Liu WT,Dybkov O,Will CL,Hartmuth K,Urlaub H,Kastner B,Stark H,L?hrmann R

Molecular architecture of the human U4/U6.U5 tri-snRNP.
Science (New York, N.Y.)351(6280)1416-20(2016 Mar)
Agafonov DE,Kastner B,Dybkov O,Hofele RV,Liu WT,Urlaub H,L?hrmann R,Stark H

Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5' splice site recognition.
eLife4(2015 Jan)
Kondo Y,Oubridge C,van Roon AM,Nagai K

Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
Nature communications54020(2014 Jun)
Navarini AA,Simpson MA,Weale M,Knight J,Carlavan I,Reiniche P,Burden DA,Layton A,Bataille V,Allen M,Pleass R,Pink A,Creamer D,English J,Munn S,Walton S,,Willis C,D?ret S,Voegel JJ,Spector T,Smith CH,Trembath RC,Barker JN

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SNRPD3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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