SUMO3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SUMO3
Entrez Gene ID	6612
Full Name	small ubiquitin-like modifier 3
Synonyms	SMT3A,SMT3H1,SUMO-3,Smt3B
General protein information	Preferred Names small ubiquitin-like modifier 3 Names small ubiquitin-related modifier 3 SMT3 suppressor of mif two 3 homolog 1 SMT3 suppressor of mif two 3 homolog 3 ubiquitin-like protein SMT3B
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 21 Map Location: 21q22.3
Summary	This gene encodes a member of the small ubiquitin-related modifier (SUMO) family of eukaryotic proteins. The encoded protein is covalently conjugated to other proteins via a post-translation modification known as sumoylation. Sumoylation may play a role in a wide variety of cellular processes, including nuclear transport, DNA replication and repair, mitosis, transcriptional regulation, and signal transduction. Alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Feb 2014].
Disorder MIM:	602231

mRNA and Protein(s)

mRNA	Protein	Name
NM_001286416.1	NP_001273345.1	small ubiquitin-related modifier 3 isoform 2
NM_006936.3	NP_008867.2	small ubiquitin-related modifier 3 isoform 1 precursor
NM_006936.2	NP_008867.2	small ubiquitin-related modifier 3 isoform 1 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	SUMO3	NP_008867.2
	SUMO3	XP_001115047.1
Bos taurus (cattle)	LOC784603	XP_005216162.1
Rattus norvegicus (Norway rat)	Sumo3	NP_001019466.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000852	XP_316822.4
Xenopus tropicalis (tropical clawed frog)	sumo3	NP_001004853.1
Pan troglodytes (chimpanzee)	SUMO3	XP_003949790.1
Danio rerio (zebrafish)	sumo3b	NP_001002677.2
Bos taurus (cattle)	SUMO3	NP_001069917.1
Mus musculus (house mouse)	Sumo3	NP_064313.1
Gallus gallus (chicken)	SUMO3	NP_001072966.1
Danio rerio (zebrafish)	sumo3a	NP_998289.1
Drosophila melanogaster (fruit fly)	smt3	NP_477411.1

Gene Ontology
Bibliography

Related articles in PubMed

Differential effects of SUMO1 and SUMO3 on PKR activation and stability.
Maarifi G, El Asmi F, Maroui MA, Dianoux L, Chelbi-Alix MK
Scientific reports8(1)1277(2018 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that PIASy exhibits a SIM (SUMO-interacting motif) in addition to the SIM identified in homologous proteins in other species; both SIMs are located near C terminus of PIASy, and both are required for full ligase activity of PIASy; hydrophobic core residues of the new SIM are essential in binding to SUMO-3. (PIASy = protein inhibitors of activated STAT y; SUMO-3 = small ubiquitin-like modifier 3)
Title: Identification of a new small ubiquitin-like modifier (SUMO)-interacting motif in the E3 ligase PIASy.

Increased post-translational modification of proteins by SUMO-2/3 is a cytoprotective response against cell stress induced by ischaemia and reperfusion.
Title: Increased SUMO-2/3-ylation mediated by SENP3 degradation is protective against cadmium-induced caspase 3-dependent cytotoxicity.

The adenovirus E4-ORF3 protein functions as a SUMO E3 ligase for TIF-1gamma sumoylation and poly-SUMO chain elongation.
Title: The adenovirus E4-ORF3 protein functions as a SUMO E3 ligase for TIF-1? sumoylation and poly-SUMO chain elongation.

FOXP2 can be modified with all three human SUMO proteins and that PIAS1 promotes this process.
Title: The language-related transcription factor FOXP2 is post-translationally modified with small ubiquitin-like modifiers.

Small ubiquitin-related modifier 2/3 interacts with p65 and stabilizes it in the cytoplasm in HBV-associated hepatocellular carcinoma.
Title: Small ubiquitin-related modifier 2/3 interacts with p65 and stabilizes it in the cytoplasm in HBV-associated hepatocellular carcinoma.

The following SUMO3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SUMO3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13327	NM_006936.3 Latest version!	Homo sapiens small ubiquitin like modifier 3 (SUMO3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OHu21227	NM_001286416.1 Latest version!	Homo sapiens small ubiquitin like modifier 3 (SUMO3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu13327	NM_006936.2	Homo sapiens small ubiquitin like modifier 3 (SUMO3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SUMO3 ( NM_006936.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_008867.2 Homo sapiens small ubiquitin like modifier 3 (SUMO3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu13327
Clone ID Related Accession (Same CDS sequence)	NM_006936.3 , NM_006936.2
Accession Version	NM_006936.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 312bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-03
Organism	Homo sapiens(human)
Product	small ubiquitin-related modifier 3 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC008420.1 and BC000036.2. On Jun 2, 2019 this sequence version replaced NM_006936.2. Transcript Variant: This variant (1) represents the predominant transcript and encodes the shorter isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.1059091.1, SRR3476690.753200.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCCGAGG AGAAGCCCAA GGAGGGTGTG AAGACAGAGA ATGACCACAT CAACCTGAAG 
GTGGCCGGGC AGGACGGCTC CGTGGTGCAG TTCAAGATCA AGAGGCACAC GCCGCTGAGC 
AAGCTGATGA AGGCCTACTG CGAGAGGCAG GGCTTGTCAA TGAGGCAGAT CAGATTCAGG 
TTCGACGGGC AGCCAATCAA TGAAACTGAC ACTCCAGCAC AGCTGGAGAT GGAGGACGAG 
GACACCATCG ACGTGTTCCA GCAGCAGACG GGAGGTGTGC CGGAGAGCAG CCTGGCAGGG 
CACAGTTTCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_008867.2
CDS	95..406
Translation	MSEEKPKEGVKTENDHINLKVAGQDGSVVQFKIKRHTPLSKLMKAYCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGGVPESSLAGHSF

Target ORF information:

RefSeq Version	NM_006936.3
Organism	Homo sapiens(human)
Definition	Homo sapiens small ubiquitin like modifier 3 (SUMO3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006936.3

ORF Insert Sequence:

ATGTCCGAGG AGAAGCCCAA GGAGGGTGTG AAGACAGAGA ATGACCACAT CAACCTGAAG 
GTGGCCGGGC AGGACGGCTC CGTGGTGCAG TTCAAGATCA AGAGGCACAC GCCGCTGAGC 
AAGCTGATGA AGGCCTACTG CGAGAGGCAG GGCTTGTCAA TGAGGCAGAT CAGATTCAGG 
TTCGACGGGC AGCCAATCAA TGAAACTGAC ACTCCAGCAC AGCTGGAGAT GGAGGACGAG 
GACACCATCG ACGTGTTCCA GCAGCAGACG GGAGGTGTGC CGGAGAGCAG CCTGGCAGGG 
CACAGTTTCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SUMO3 ( NM_006936.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_008867.2 Homo sapiens small ubiquitin like modifier 3 (SUMO3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu13327
Clone ID Related Accession (Same CDS sequence)	NM_006936.3 , NM_006936.2
Accession Version	NM_006936.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 312bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-19
Organism	Homo sapiens(human)
Product	small ubiquitin-related modifier 3 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC008420.1 and BC000036.2. On Jun 18, 2004 this sequence version replaced NM_006936.1. Transcript Variant: This variant (1) represents the predominant transcript and encodes the shorter isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279826.1532.1, SRR1163655.9831.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCGAGG AGAAGCCCAA GGAGGGTGTG AAGACAGAGA ATGACCACAT CAACCTGAAG 
GTGGCCGGGC AGGACGGCTC CGTGGTGCAG TTCAAGATCA AGAGGCACAC GCCGCTGAGC 
AAGCTGATGA AGGCCTACTG CGAGAGGCAG GGCTTGTCAA TGAGGCAGAT CAGATTCAGG 
TTCGACGGGC AGCCAATCAA TGAAACTGAC ACTCCAGCAC AGCTGGAGAT GGAGGACGAG 
GACACCATCG ACGTGTTCCA GCAGCAGACG GGAGGTGTGC CGGAGAGCAG CCTGGCAGGG 
CACAGTTTCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_008867.2
CDS	162..473
Translation	MSEEKPKEGVKTENDHINLKVAGQDGSVVQFKIKRHTPLSKLMKAYCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGGVPESSLAGHSF

Target ORF information:

RefSeq Version	NM_006936.2
Organism	Homo sapiens(human)
Definition	Homo sapiens small ubiquitin like modifier 3 (SUMO3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006936.2

ORF Insert Sequence:

ATGTCCGAGG AGAAGCCCAA GGAGGGTGTG AAGACAGAGA ATGACCACAT CAACCTGAAG 
GTGGCCGGGC AGGACGGCTC CGTGGTGCAG TTCAAGATCA AGAGGCACAC GCCGCTGAGC 
AAGCTGATGA AGGCCTACTG CGAGAGGCAG GGCTTGTCAA TGAGGCAGAT CAGATTCAGG 
TTCGACGGGC AGCCAATCAA TGAAACTGAC ACTCCAGCAC AGCTGGAGAT GGAGGACGAG 
GACACCATCG ACGTGTTCCA GCAGCAGACG GGAGGTGTGC CGGAGAGCAG CCTGGCAGGG 
CACAGTTTCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SUMO3 ( NM_001286416.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001273345.1 Homo sapiens small ubiquitin like modifier 3 (SUMO3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu21227
Clone ID Related Accession (Same CDS sequence)	NM_001286416.1
Accession Version	NM_001286416.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 426bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-01
Organism	Homo sapiens(human)
Product	small ubiquitin-related modifier 3 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC008420.1, AK300822.1 and BC000036.2. This sequence is a reference standard in the RefSeqGene project. On Nov 5, 2013 this sequence version replaced XM_005261165.1. Transcript Variant: This variant (2) uses an alternate in-frame acceptor splice site compared to variant 1. The resulting longer isoform (2) has an internal protein segment not found in isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK300822.1, DC387242.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2149004 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCGAGG AGAAGCCCAA GGAGGGTGTG AAGACAGAGA ATGACCACAT CAACCTGAAG 
GTGGCCGGGC AGGACGGCTC CGTGGTGCAG TTCAAGATCA AGAGGCACAC GCCGCTGAGC 
AAGCTGATGA AGGCCTACTG CGAGAGGCAG GTGCGGCACC TTGCTCCCCC GCAGAGCCTC 
CCCGTGTGCG CACTGGTCCT GTGCGTTCCA GGCATCCCCA GAGCACGAGC GTCTCGGGGC 
TGGACCCAGA TGCAGCTGCC CGAGGGCTTG TCAATGAGGC AGATCAGATT CAGGTTCGAC 
GGGCAGCCAA TCAATGAAAC TGACACTCCA GCACAGCTGG AGATGGAGGA CGAGGACACC 
ATCGACGTGT TCCAGCAGCA GACGGGAGGT GTGCCGGAGA GCAGCCTGGC AGGGCACAGT 
TTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001273345.1
CDS	162..587
Translation	MSEEKPKEGVKTENDHINLKVAGQDGSVVQFKIKRHTPLSKLMKAYCERQVRHLAPPQSLPVCALVLCVPGIPRARASRGWTQMQLPEGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGGVPESSLAGHSF

Target ORF information:

RefSeq Version	NM_001286416.1
Organism	Homo sapiens(human)
Definition	Homo sapiens small ubiquitin like modifier 3 (SUMO3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001286416.1

ORF Insert Sequence:

ATGTCCGAGG AGAAGCCCAA GGAGGGTGTG AAGACAGAGA ATGACCACAT CAACCTGAAG 
GTGGCCGGGC AGGACGGCTC CGTGGTGCAG TTCAAGATCA AGAGGCACAC GCCGCTGAGC 
AAGCTGATGA AGGCCTACTG CGAGAGGCAG GTGCGGCACC TTGCTCCCCC GCAGAGCCTC 
CCCGTGTGCG CACTGGTCCT GTGCGTTCCA GGCATCCCCA GAGCACGAGC GTCTCGGGGC 
TGGACCCAGA TGCAGCTGCC CGAGGGCTTG TCAATGAGGC AGATCAGATT CAGGTTCGAC 
GGGCAGCCAA TCAATGAAAC TGACACTCCA GCACAGCTGG AGATGGAGGA CGAGGACACC 
ATCGACGTGT TCCAGCAGCA GACGGGAGGT GTGCCGGAGA GCAGCCTGGC AGGGCACAGT 
TTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Differential effects of SUMO1 and SUMO3 on PKR activation and stability.
Scientific reports8(1)1277(2018 Jan)
Maarifi G,El Asmi F,Maroui MA,Dianoux L,Chelbi-Alix MK

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SUMO3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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