SLC22A2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SLC22A2
Entrez Gene ID	6582
Full Name	solute carrier family 22 member 2
Synonyms	OCT2
General protein information	Preferred Names solute carrier family 22 member 2 Names solute carrier family 22 member 2 organic cation transporter 2 solute carrier family 22 (organic cation transporter), member 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6q25.3
Summary	Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption. [provided by RefSeq, Jul 2008].
Disorder MIM:	602608

mRNA and Protein(s)

mRNA	Protein	Name
NM_003058.4	NP_003049.2	solute carrier family 22 member 2
NM_003058.3	NP_003049.2	solute carrier family 22 member 2

Pathways from BioSystems

Homologies

Bos taurus (cattle)	SLC22A2	XP_002690417.1
Mus musculus (house mouse)	Slc22a2	NP_038695.1
Homo sapiens (human)	SLC22A2	NP_003049.2
	LOC708988	XP_002804005.1
Danio rerio (zebrafish)	slc22a2	NP_998315.1
Pan troglodytes (chimpanzee)	SLC22A2	XP_003311617.1
Canis lupus familiaris (dog)	SLC22A2	XP_533466.2
Gallus gallus (chicken)	LOC421584	XP_419622.2
Xenopus tropicalis (tropical clawed frog)	LOC100487774	XP_002933908.1
Rattus norvegicus (Norway rat)	Slc22a2	NP_113772.1
Gallus gallus (chicken)	SLC22A2	XP_419621.3

Gene Ontology
Bibliography

Related articles in PubMed

Potential role of polymorphisms in the transporter genes ENT1 and MATE1/OCT2 in predicting TAS-102 efficacy and toxicity in patients with refractory metastatic colorectal cancer.
Suenaga M, Schirripa M, Cao S, Zhang W, Yang D, Dadduzio V, Salvatore L, Borelli B, Pietrantonio F, Ning Y, Okazaki S, Berger MD, Miyamoto Y, Gopez R Jr, Barzi A, Yamaguchi T, Loupakis F, Lenz HJ
European journal of cancer (Oxford, England : 1990)86197-206(2017 11)

Effects of genetic polymorphisms on the OCT1 and OCT2-mediated uptake of ranitidine.
Meyer MJ, Seitz T, Brockm?ller J, Tzvetkov MV
PloS one12(12)e0189521(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The combination of ENT1, MATE1 and OCT2 SNPs may serve as a predictive and prognostic marker in metastatic colorectal carcinoma patients treated with TAS-102.
Title: Potential role of polymorphisms in the transporter genes ENT1 and MATE1/OCT2 in predicting TAS-102 efficacy and toxicity in patients with refractory metastatic colorectal cancer.

we assessed the role of miR-21 in mediating renal cell carcinoma chemoresistance and further showed that miR-21 silencing significantly (1) increased chemosensitivity of paclitaxel, 5-fluorouracil, oxaliplatin, and dovitinib; (2) decreased expression of multi-drug resistance genes; and (4) increased SLC22A1/OCT1, SLC22A2/OCT2, and SLC31A1/CTR1 platinum influx transporter expression
Title: Targeting miR-21 decreases expression of multi-drug resistant genes and promotes chemosensitivity of renal carcinoma.

Formononetin prevents cisplatin-induced acute kidney injury by targeting Oct2/TP53 in the kidney.
Title: Targeting Oct2 and P53: Formononetin prevents cisplatin-induced acute kidney injury.

inhibitory potency for morphine uptake was affected by the OCT1*2 allele. OCT2 showed only a limited uptake of ranitidine that was not significantly affected by the Ala270Ser polymorphism
Title: Effects of genetic polymorphisms on the OCT1 and OCT2-mediated uptake of ranitidine.

This study of SLC22A2 contributes in filling the gap that exists with regards to genetic information about important variations in organic cation transporter genes for the indigenous populations of South Africa.
Title: SLC22A2 - mapping genomic variations within South African indigenous and admixed populations.

The following SLC22A2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLC22A2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21917	NM_003058.4 Latest version!	Homo sapiens solute carrier family 22 member 2 (SLC22A2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
View Old Accession Versions >>
OHu21917	NM_003058.3	Homo sapiens solute carrier family 22 member 2 (SLC22A2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SLC22A2 ( NM_003058.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003049.2 Homo sapiens solute carrier family 22 member 2 (SLC22A2), mRNA.

Price & Availability↑

CloneID	OHu21917
Clone ID Related Accession (Same CDS sequence)	NM_003058.4 , NM_003058.3
Accession Version	NM_003058.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1668bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-06
Organism	Homo sapiens(human)
Product	solute carrier family 22 member 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL162582.30. On Nov 22, 2018 this sequence version replaced NM_003058.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.133698.1, BC039899.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1970526, SAMEA2142348 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000366953.8/ ENSP00000355920.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCCACCA CCGTGGACGA TGTCCTGGAG CATGGAGGGG AGTTTCACTT TTTCCAGAAG 
CAAATGTTTT TCCTCTTGGC TCTGCTCTCG GCTACCTTCG CGCCCATCTA CGTGGGCATC 
GTCTTCCTGG GCTTCACCCC TGACCACCGC TGCCGGAGCC CCGGAGTGGC CGAGCTGAGT 
CTGCGCTGCG GCTGGAGTCC TGCAGAGGAA CTGAACTACA CGGTGCCGGG CCCAGGACCT 
GCGGGCGAAG CCTCCCCAAG ACAGTGTAGG CGCTACGAGG TGGACTGGAA CCAGAGCACC 
TTCGACTGCG TGGACCCCCT GGCCAGCCTG GACACCAACA GGAGCCGCCT GCCACTGGGC 
CCCTGCCGGG ACGGCTGGGT GTACGAGACG CCTGGCTCGT CCATCGTCAC CGAGTTTAAC 
CTGGTATGTG CCAACTCCTG GATGTTGGAC CTATTCCAGT CATCAGTGAA TGTAGGATTC 
TTTATTGGCT CTATGAGTAT CGGCTACATA GCAGACAGGT TTGGCCGTAA GCTCTGCCTC 
CTAACTACAG TCCTCATAAA TGCTGCAGCT GGAGTTCTCA TGGCCATTTC CCCAACCTAT 
ACGTGGATGT TAATTTTTCG CTTAATCCAA GGACTGGTCA GCAAAGCAGG CTGGTTAATA 
GGCTACATCC TGATTACAGA ATTTGTTGGG CGGAGATATC GGAGAACAGT GGGGATTTTT 
TACCAAGTTG CCTATACAGT TGGGCTCCTG GTGCTAGCTG GGGTGGCTTA CGCACTTCCT 
CACTGGAGGT GGTTGCAGTT CACAGTTTCT CTGCCCAACT TCTTCTTCTT GCTCTATTAC 
TGGTGCATAC CTGAGTCTCC CAGGTGGCTG ATCTCCCAGA ATAAGAATGC TGAAGCCATG 
AGAATCATTA AGCACATCGC AAAGAAAAAT GGAAAATCTC TACCCGCCTC CCTTCAGCGC 
CTGAGACTTG AAGAGGAAAC TGGCAAGAAA TTGAACCCTT CATTTCTTGA CTTGGTCAGA 
ACTCCTCAGA TAAGGAAACA TACTATGATA TTGATGTACA ACTGGTTCAC GAGCTCTGTG 
CTCTACCAGG GCCTCATCAT GCACATGGGC CTTGCAGGTG ACAATATCTA CCTGGATTTC 
TTCTACTCTG CCCTGGTTGA ATTCCCAGCT GCCTTCATGA TCATCCTCAC CATCGACCGC 
ATCGGACGCC GTTACCCTTG GGCTGCATCA AATATGGTTG CAGGGGCAGC CTGTCTGGCC 
TCAGTTTTTA TACCTGGTGA TCTACAATGG CTAAAAATTA TTATCTCATG CTTGGGAAGA 
ATGGGGATCA CAATGGCCTA TGAGATAGTC TGCCTGGTCA ATGCTGAGCT GTACCCCACA 
TTCATTAGGA ATCTTGGCGT CCACATCTGT TCCTCAATGT GTGACATTGG TGGCATCATC 
ACGCCATTCC TGGTCTACCG GCTCACTAAC ATCTGGCTTG AGCTCCCGCT GATGGTTTTC 
GGCGTGCTTG GCTTGGTTGC TGGAGGTCTG GTGCTGTTGC TTCCAGAAAC TAAAGGGAAA 
GCTTTGCCTG AGACCATCGA GGAAGCCGAA AATATGCAAA GACCAAGAAA AAATAAAGAA 
AAGATGATTT ACCTCCAAGT TCAGAAACTA GACATTCCAT TGAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003049.2
CDS	65..1732
Translation	MPTTVDDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGVAELSLRCGWSPAEELNYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLGPCRDGWVYETPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIFYQVAYTVGLLVLAGVAYALPHWRWLQFTVSLPNFFFLLYYWCIPESPRWLISQNKNAEAMRIIKHIAKKNGKSLPASLQRLRLEEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFTSSVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLASVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQRPRKNKEKMIYLQVQKLDIPLN

Target ORF information:

RefSeq Version	NM_003058.4
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 22 member 2 (SLC22A2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003058.4

ORF Insert Sequence:

ATGCCCACCA CCGTGGACGA TGTCCTGGAG CATGGAGGGG AGTTTCACTT TTTCCAGAAG 
CAAATGTTTT TCCTCTTGGC TCTGCTCTCG GCTACCTTCG CGCCCATCTA CGTGGGCATC 
GTCTTCCTGG GCTTCACCCC TGACCACCGC TGCCGGAGCC CCGGAGTGGC CGAGCTGAGT 
CTGCGCTGCG GCTGGAGTCC TGCAGAGGAA CTGAACTACA CGGTGCCGGG CCCAGGACCT 
GCGGGCGAAG CCTCCCCAAG ACAGTGTAGG CGCTACGAGG TGGACTGGAA CCAGAGCACC 
TTCGACTGCG TGGACCCCCT GGCCAGCCTG GACACCAACA GGAGCCGCCT GCCACTGGGC 
CCCTGCCGGG ACGGCTGGGT GTACGAGACG CCTGGCTCGT CCATCGTCAC CGAGTTTAAC 
CTGGTATGTG CCAACTCCTG GATGTTGGAC CTATTCCAGT CATCAGTGAA TGTAGGATTC 
TTTATTGGCT CTATGAGTAT CGGCTACATA GCAGACAGGT TTGGCCGTAA GCTCTGCCTC 
CTAACTACAG TCCTCATAAA TGCTGCAGCT GGAGTTCTCA TGGCCATTTC CCCAACCTAT 
ACGTGGATGT TAATTTTTCG CTTAATCCAA GGACTGGTCA GCAAAGCAGG CTGGTTAATA 
GGCTACATCC TGATTACAGA ATTTGTTGGG CGGAGATATC GGAGAACAGT GGGGATTTTT 
TACCAAGTTG CCTATACAGT TGGGCTCCTG GTGCTAGCTG GGGTGGCTTA CGCACTTCCT 
CACTGGAGGT GGTTGCAGTT CACAGTTTCT CTGCCCAACT TCTTCTTCTT GCTCTATTAC 
TGGTGCATAC CTGAGTCTCC CAGGTGGCTG ATCTCCCAGA ATAAGAATGC TGAAGCCATG 
AGAATCATTA AGCACATCGC AAAGAAAAAT GGAAAATCTC TACCCGCCTC CCTTCAGCGC 
CTGAGACTTG AAGAGGAAAC TGGCAAGAAA TTGAACCCTT CATTTCTTGA CTTGGTCAGA 
ACTCCTCAGA TAAGGAAACA TACTATGATA TTGATGTACA ACTGGTTCAC GAGCTCTGTG 
CTCTACCAGG GCCTCATCAT GCACATGGGC CTTGCAGGTG ACAATATCTA CCTGGATTTC 
TTCTACTCTG CCCTGGTTGA ATTCCCAGCT GCCTTCATGA TCATCCTCAC CATCGACCGC 
ATCGGACGCC GTTACCCTTG GGCTGCATCA AATATGGTTG CAGGGGCAGC CTGTCTGGCC 
TCAGTTTTTA TACCTGGTGA TCTACAATGG CTAAAAATTA TTATCTCATG CTTGGGAAGA 
ATGGGGATCA CAATGGCCTA TGAGATAGTC TGCCTGGTCA ATGCTGAGCT GTACCCCACA 
TTCATTAGGA ATCTTGGCGT CCACATCTGT TCCTCAATGT GTGACATTGG TGGCATCATC 
ACGCCATTCC TGGTCTACCG GCTCACTAAC ATCTGGCTTG AGCTCCCGCT GATGGTTTTC 
GGCGTGCTTG GCTTGGTTGC TGGAGGTCTG GTGCTGTTGC TTCCAGAAAC TAAAGGGAAA 
GCTTTGCCTG AGACCATCGA GGAAGCCGAA AATATGCAAA GACCAAGAAA AAATAAAGAA 
AAGATGATTT ACCTCCAAGT TCAGAAACTA GACATTCCAT TGAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLC22A2 ( NM_003058.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003049.2 Homo sapiens solute carrier family 22 member 2 (SLC22A2), mRNA.

Price & Availability↑

CloneID	OHu21917
Clone ID Related Accession (Same CDS sequence)	NM_003058.4 , NM_003058.3
Accession Version	NM_003058.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1668bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-28
Organism	Homo sapiens(human)
Product	solute carrier family 22 member 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL162582.30. On Aug 4, 2010 this sequence version replaced NM_003058.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.133698.1, BC039899.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1970526, SAMEA2142348 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCACCA CCGTGGACGA TGTCCTGGAG CATGGAGGGG AGTTTCACTT TTTCCAGAAG 
CAAATGTTTT TCCTCTTGGC TCTGCTCTCG GCTACCTTCG CGCCCATCTA CGTGGGCATC 
GTCTTCCTGG GCTTCACCCC TGACCACCGC TGCCGGAGCC CCGGAGTGGC CGAGCTGAGT 
CTGCGCTGCG GCTGGAGTCC TGCAGAGGAA CTGAACTACA CGGTGCCGGG CCCAGGACCT 
GCGGGCGAAG CCTCCCCAAG ACAGTGTAGG CGCTACGAGG TGGACTGGAA CCAGAGCACC 
TTCGACTGCG TGGACCCCCT GGCCAGCCTG GACACCAACA GGAGCCGCCT GCCACTGGGC 
CCCTGCCGGG ACGGCTGGGT GTACGAGACG CCTGGCTCGT CCATCGTCAC CGAGTTTAAC 
CTGGTATGTG CCAACTCCTG GATGTTGGAC CTATTCCAGT CATCAGTGAA TGTAGGATTC 
TTTATTGGCT CTATGAGTAT CGGCTACATA GCAGACAGGT TTGGCCGTAA GCTCTGCCTC 
CTAACTACAG TCCTCATAAA TGCTGCAGCT GGAGTTCTCA TGGCCATTTC CCCAACCTAT 
ACGTGGATGT TAATTTTTCG CTTAATCCAA GGACTGGTCA GCAAAGCAGG CTGGTTAATA 
GGCTACATCC TGATTACAGA ATTTGTTGGG CGGAGATATC GGAGAACAGT GGGGATTTTT 
TACCAAGTTG CCTATACAGT TGGGCTCCTG GTGCTAGCTG GGGTGGCTTA CGCACTTCCT 
CACTGGAGGT GGTTGCAGTT CACAGTTTCT CTGCCCAACT TCTTCTTCTT GCTCTATTAC 
TGGTGCATAC CTGAGTCTCC CAGGTGGCTG ATCTCCCAGA ATAAGAATGC TGAAGCCATG 
AGAATCATTA AGCACATCGC AAAGAAAAAT GGAAAATCTC TACCCGCCTC CCTTCAGCGC 
CTGAGACTTG AAGAGGAAAC TGGCAAGAAA TTGAACCCTT CATTTCTTGA CTTGGTCAGA 
ACTCCTCAGA TAAGGAAACA TACTATGATA TTGATGTACA ACTGGTTCAC GAGCTCTGTG 
CTCTACCAGG GCCTCATCAT GCACATGGGC CTTGCAGGTG ACAATATCTA CCTGGATTTC 
TTCTACTCTG CCCTGGTTGA ATTCCCAGCT GCCTTCATGA TCATCCTCAC CATCGACCGC 
ATCGGACGCC GTTACCCTTG GGCTGCATCA AATATGGTTG CAGGGGCAGC CTGTCTGGCC 
TCAGTTTTTA TACCTGGTGA TCTACAATGG CTAAAAATTA TTATCTCATG CTTGGGAAGA 
ATGGGGATCA CAATGGCCTA TGAGATAGTC TGCCTGGTCA ATGCTGAGCT GTACCCCACA 
TTCATTAGGA ATCTTGGCGT CCACATCTGT TCCTCAATGT GTGACATTGG TGGCATCATC 
ACGCCATTCC TGGTCTACCG GCTCACTAAC ATCTGGCTTG AGCTCCCGCT GATGGTTTTC 
GGCGTGCTTG GCTTGGTTGC TGGAGGTCTG GTGCTGTTGC TTCCAGAAAC TAAAGGGAAA 
GCTTTGCCTG AGACCATCGA GGAAGCCGAA AATATGCAAA GACCAAGAAA AAATAAAGAA 
AAGATGATTT ACCTCCAAGT TCAGAAACTA GACATTCCAT TGAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003049.2
CDS	175..1842
Translation	MPTTVDDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGVAELSLRCGWSPAEELNYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLGPCRDGWVYETPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIFYQVAYTVGLLVLAGVAYALPHWRWLQFTVSLPNFFFLLYYWCIPESPRWLISQNKNAEAMRIIKHIAKKNGKSLPASLQRLRLEEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFTSSVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLASVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQRPRKNKEKMIYLQVQKLDIPLN

Target ORF information:

RefSeq Version	NM_003058.3
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 22 member 2 (SLC22A2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003058.3

ORF Insert Sequence:

ATGCCCACCA CCGTGGACGA TGTCCTGGAG CATGGAGGGG AGTTTCACTT TTTCCAGAAG 
CAAATGTTTT TCCTCTTGGC TCTGCTCTCG GCTACCTTCG CGCCCATCTA CGTGGGCATC 
GTCTTCCTGG GCTTCACCCC TGACCACCGC TGCCGGAGCC CCGGAGTGGC CGAGCTGAGT 
CTGCGCTGCG GCTGGAGTCC TGCAGAGGAA CTGAACTACA CGGTGCCGGG CCCAGGACCT 
GCGGGCGAAG CCTCCCCAAG ACAGTGTAGG CGCTACGAGG TGGACTGGAA CCAGAGCACC 
TTCGACTGCG TGGACCCCCT GGCCAGCCTG GACACCAACA GGAGCCGCCT GCCACTGGGC 
CCCTGCCGGG ACGGCTGGGT GTACGAGACG CCTGGCTCGT CCATCGTCAC CGAGTTTAAC 
CTGGTATGTG CCAACTCCTG GATGTTGGAC CTATTCCAGT CATCAGTGAA TGTAGGATTC 
TTTATTGGCT CTATGAGTAT CGGCTACATA GCAGACAGGT TTGGCCGTAA GCTCTGCCTC 
CTAACTACAG TCCTCATAAA TGCTGCAGCT GGAGTTCTCA TGGCCATTTC CCCAACCTAT 
ACGTGGATGT TAATTTTTCG CTTAATCCAA GGACTGGTCA GCAAAGCAGG CTGGTTAATA 
GGCTACATCC TGATTACAGA ATTTGTTGGG CGGAGATATC GGAGAACAGT GGGGATTTTT 
TACCAAGTTG CCTATACAGT TGGGCTCCTG GTGCTAGCTG GGGTGGCTTA CGCACTTCCT 
CACTGGAGGT GGTTGCAGTT CACAGTTTCT CTGCCCAACT TCTTCTTCTT GCTCTATTAC 
TGGTGCATAC CTGAGTCTCC CAGGTGGCTG ATCTCCCAGA ATAAGAATGC TGAAGCCATG 
AGAATCATTA AGCACATCGC AAAGAAAAAT GGAAAATCTC TACCCGCCTC CCTTCAGCGC 
CTGAGACTTG AAGAGGAAAC TGGCAAGAAA TTGAACCCTT CATTTCTTGA CTTGGTCAGA 
ACTCCTCAGA TAAGGAAACA TACTATGATA TTGATGTACA ACTGGTTCAC GAGCTCTGTG 
CTCTACCAGG GCCTCATCAT GCACATGGGC CTTGCAGGTG ACAATATCTA CCTGGATTTC 
TTCTACTCTG CCCTGGTTGA ATTCCCAGCT GCCTTCATGA TCATCCTCAC CATCGACCGC 
ATCGGACGCC GTTACCCTTG GGCTGCATCA AATATGGTTG CAGGGGCAGC CTGTCTGGCC 
TCAGTTTTTA TACCTGGTGA TCTACAATGG CTAAAAATTA TTATCTCATG CTTGGGAAGA 
ATGGGGATCA CAATGGCCTA TGAGATAGTC TGCCTGGTCA ATGCTGAGCT GTACCCCACA 
TTCATTAGGA ATCTTGGCGT CCACATCTGT TCCTCAATGT GTGACATTGG TGGCATCATC 
ACGCCATTCC TGGTCTACCG GCTCACTAAC ATCTGGCTTG AGCTCCCGCT GATGGTTTTC 
GGCGTGCTTG GCTTGGTTGC TGGAGGTCTG GTGCTGTTGC TTCCAGAAAC TAAAGGGAAA 
GCTTTGCCTG AGACCATCGA GGAAGCCGAA AATATGCAAA GACCAAGAAA AAATAAAGAA 
AAGATGATTT ACCTCCAAGT TCAGAAACTA GACATTCCAT TGAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Potential role of polymorphisms in the transporter genes ENT1 and MATE1/OCT2 in predicting TAS-102 efficacy and toxicity in patients with refractory metastatic colorectal cancer.
European journal of cancer (Oxford, England : 1990)86197-206(2017 11)
Suenaga M,Schirripa M,Cao S,Zhang W,Yang D,Dadduzio V,Salvatore L,Borelli B,Pietrantonio F,Ning Y,Okazaki S,Berger MD,Miyamoto Y,Gopez R Jr,Barzi A,Yamaguchi T,Loupakis F,Lenz HJ

Effects of genetic polymorphisms on the OCT1 and OCT2-mediated uptake of ranitidine.
PloS one12(12)e0189521(2017)
Meyer MJ,Seitz T,Brockm?ller J,Tzvetkov MV

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SLC22A2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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