SLC18A2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SLC18A2
Entrez Gene ID	6571
Full Name	solute carrier family 18 member A2
Synonyms	SVAT,SVMT,VAT2,VMAT2
General protein information	Preferred Names solute carrier family 18 member A2 Names synaptic vesicular amine transporter monoamine neurotransmitter transporter monoamine transporter solute carrier family 18 (vesicular monoamine transporter), member 2 solute carrier family 18 (vesicular monoamine), member 2 solute carrier family 18 member 2 vesicle monoamine transporter type 2 vesicle monoamine/H+ antiporter vesicular amine transporter 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10q25.3
Summary	The vesicular monoamine transporter acts to accumulate cytosolic monoamines into synaptic vesicles, using the proton gradient maintained across the synaptic vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (summary by Peter et al., 1993 [PubMed 7905859]). See also SLC18A1 (MIM 193002).[supplied by OMIM, Jan 2011].
Disorder MIM:	193001

mRNA and Protein(s)

mRNA	Protein	Name
NM_003054.4	NP_003045.2	synaptic vesicular amine transporter
NM_003054.6	NP_003045.2	synaptic vesicular amine transporter

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	SLC18A2	XP_521615.3
Bos taurus (cattle)	SLC18A2	NP_777078.1
Rattus norvegicus (Norway rat)	Slc18a2	NP_037163.1
Gallus gallus (chicken)	SLC18A2	XP_421782.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004476	XP_313775.4
Caenorhabditis elegans (roundworm)	cat-1	NP_001024936.1
Homo sapiens (human)	SLC18A2	NP_003045.2
Mus musculus (house mouse)	Slc18a2	NP_766111.1
	SLC18A2	XP_001095699.2
Canis lupus familiaris (dog)	SLC18A2	XP_544038.2
Danio rerio (zebrafish)	slc18a2	NP_001243154.1
Drosophila melanogaster (fruit fly)	Vmat	NP_001014524.1

Gene Ontology
Bibliography

Related articles in PubMed

Association analysis of polymorphisms in VMAT2 and TMEM106B genes for Parkinson's disease, amyotrophic lateral sclerosis and multiple system atrophy.
Hu T, Chen Y, Ou R, Wei Q, Cao B, Zhao B, Wu Y, Song W, Chen X, Shang HF
Journal of the neurological sciences37765-71(2017 Jun)

Genetic variations in the 3'-untranslated region of SLC18A2 are associated with serum FSH concentration in polycystic ovary syndrome patients and regulate gene expression in vitro.
Li Q, Yan Z, Kuang Y, Zhou X, Jin L, He L, Sun X, Tao T, Wang L
Human reproduction (Oxford, England)31(9)2150-7(2016 Sep)

hVMAT2: A Target of Individualized Medication for Parkinson's Disease.
Xiong N, Li N, Martin E, Yu J, Li J, Liu J, Lee DY, Isacson O, Vance J, Qing H, Wang T, Lin Z
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics13(3)623-34(2016 07)

Large-scale evaluation of SLC18A2 in prostate cancer reveals diagnostic and prognostic biomarker potential at three molecular levels.
Haldrup C, Lynnerup AS, Storebjerg TM, Vang S, Wild P, Visakorpi T, Arsov C, Schulz WA, Lindberg J, Gr?nberg H, Egevad L, Borre M, ?rntoft TF, H?yer S, S?rensen KD
Molecular oncology10(6)825-37(2016 06)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study found that 2 promoter regions of Vesicular monoamine transporter 2 (hVMAT2) are associated with Parkinson's disease. Study shows that low-activity haplotypes may confer more vulnerability in the presence of a neurotoxin and that hVMAT2 activity could be inhibited by DNA methylation in human dopaminergic neurons.
Title: hVMAT2: A Target of Individualized Medication for Parkinson's Disease.

The SLC18A2 gene is hypermethylated and downregulated in prostate cancer (PC). SLC18A2 hypermethylation has promising diagnostic biomarker potential for PC.
Title: Large-scale evaluation of SLC18A2 in prostate cancer reveals diagnostic and prognostic biomarker potential at three molecular levels.

No statistically significant differences were found between cases and controls for the allele frequencies in five genes: TH, SLC18A2, DRD1, DRD3 and COMT. Conversely, some alleles of the 12 sNPs from the DRD2 locus and the 5 from the MAOA locus showed significant associations with excessive alcohol consumption.
Title: Influence of Dopaminergic System Genetic Variation and Lifestyle Factors on Excessive Alcohol Consumption.

describe a second case of infantile-onset movement disorder caused by a different mutation in SLC18A2 compared to PMID:23363473, and partial improvement of symptoms upon treatment with pramipexole; supports identification of causal mutation in index case.
Title: Brain dopamine-serotonin vesicular transport disease presenting as a severe infantile hypotonic parkinsonian disorder.

VMAT1 and VMAT2 are expressed in the majority of neuroblastomas
Title: Vesicular monoamine transporter protein expression correlates with clinical features, tumor biology, and MIBG avidity in neuroblastoma: a report from the Children's Oncology Group.

The following SLC18A2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLC18A2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu10952	NM_003054.6 Latest version!	Homo sapiens solute carrier family 18 member A2 (SLC18A2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
View Old Accession Versions >>
OHu10952	NM_003054.4	Homo sapiens solute carrier family 18 member A2 (SLC18A2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SLC18A2 ( NM_003054.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003045.2 Homo sapiens solute carrier family 18 member A2 (SLC18A2), mRNA.

Price & Availability↑

CloneID	OHu10952
Clone ID Related Accession (Same CDS sequence)	NM_003054.4 , NM_003054.6
Accession Version	NM_003054.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1545bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-11
Organism	Homo sapiens(human)
Product	synaptic vesicular amine transporter
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB458870.1, L23205.1, AL391988.14 and BQ416859.1. On Apr 25, 2010 this sequence version replaced NM_003054.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.68719.1, SRR1803615.245761.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCCTGA GCGAGCTGGC GCTGGTCCGC TGGCTGCAGG AGAGCCGCCG CTCGCGGAAG 
CTCATCCTGT TCATCGTGTT CCTGGCGCTG CTGCTGGACA ACATGCTGCT CACTGTCGTG 
GTCCCCATCA TCCCAAGTTA TCTGTACAGC ATTAAGCATG AGAAGAATGC TACAGAAATC 
CAGACGGCCA GGCCAGTGCA CACTGCCTCC ATCTCAGACA GCTTCCAGAG CATCTTCTCC 
TATTATGATA ACTCGACTAT GGTCACCGGG AATGCTACCA GAGACCTGAC ACTTCATCAG 
ACCGCCACAC AGCACATGGT GACCAACGCG TCCGCTGTTC CTTCCGACTG TCCCAGTGAA 
GACAAAGACC TCCTGAATGA AAACGTGCAA GTTGGTCTGT TGTTTGCCTC GAAAGCCACC 
GTCCAGCTCA TCACCAACCC TTTCATAGGA CTACTGACCA ACAGAATTGG CTATCCAATT 
CCCATATTTG CGGGATTCTG CATCATGTTT GTCTCAACAA TTATGTTTGC CTTCTCCAGC 
AGCTATGCCT TCCTGCTGAT TGCCAGGTCG CTGCAGGGCA TCGGCTCGTC CTGCTCCTCT 
GTGGCTGGGA TGGGCATGCT TGCCAGTGTC TACACAGATG ATGAAGAGAG AGGCAACGTC 
ATGGGAATCG CCTTGGGAGG CCTGGCCATG GGGGTCTTAG TGGGCCCCCC CTTCGGGAGT 
GTGCTCTATG AGTTTGTGGG GAAGACGGCT CCGTTCCTGG TGCTGGCCGC CCTGGTACTC 
TTGGATGGAG CTATTCAGCT CTTTGTGCTC CAGCCGTCCC GGGTGCAGCC AGAGAGTCAG 
AAGGGGACAC CCCTAACCAC GCTGCTGAAG GACCCGTACA TCCTCATTGC TGCAGGCTCC 
ATCTGCTTTG CAAACATGGG CATCGCCATG CTGGAGCCAG CCCTGCCCAT CTGGATGATG 
GAGACCATGT GTTCCCGAAA GTGGCAGCTG GGCGTTGCCT TCTTGCCAGC TAGTATCTCT 
TATCTCATTG GAACCAATAT TTTTGGGATA CTTGCACACA AAATGGGGAG GTGGCTTTGT 
GCTCTTCTGG GAATGATAAT TGTTGGAGTC AGCATTTTAT GTATTCCATT TGCAAAAAAC 
ATTTATGGAC TCATAGCTCC GAACTTTGGA GTTGGTTTTG CAATTGGAAT GGTGGATTCG 
TCAATGATGC CTATCATGGG CTACCTCGTA GACCTGCGGC ACGTGTCCGT CTATGGGAGT 
GTGTACGCCA TTGCGGATGT GGCATTTTGT ATGGGGTATG CTATAGGTCC TTCTGCTGGT 
GGTGCTATTG CAAAGGCAAT TGGATTTCCA TGGCTCATGA CAATTATTGG GATAATTGAT 
ATTCTTTTTG CCCCTCTCTG CTTTTTTCTT CGAAGTCCAC CTGCCAAAGA AGAAAAAATG 
GCTATTCTCA TGGATCACAA CTGCCCTATT AAAACAAAAA TGTACACTCA GAATAATATC 
CAGTCATATC CGATAGGTGA AGATGAAGAA TCTGAAAGTG ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003045.2
CDS	164..1708
Translation	MALSELALVRWLQESRRSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNATEIQTARPVHTASISDSFQSIFSYYDNSTMVTGNATRDLTLHQTATQHMVTNASAVPSDCPSEDKDLLNENVQVGLLFASKATVQLITNPFIGLLTNRIGYPIPIFAGFCIMFVSTIMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGNVMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMIIVGVSILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDILFAPLCFFLRSPPAKEEKMAILMDHNCPIKTKMYTQNNIQSYPIGEDEESESD

Target ORF information:

RefSeq Version	NM_003054.4
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 18 member A2 (SLC18A2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003054.4

ORF Insert Sequence:

ATGGCCCTGA GCGAGCTGGC GCTGGTCCGC TGGCTGCAGG AGAGCCGCCG CTCGCGGAAG 
CTCATCCTGT TCATCGTGTT CCTGGCGCTG CTGCTGGACA ACATGCTGCT CACTGTCGTG 
GTCCCCATCA TCCCAAGTTA TCTGTACAGC ATTAAGCATG AGAAGAATGC TACAGAAATC 
CAGACGGCCA GGCCAGTGCA CACTGCCTCC ATCTCAGACA GCTTCCAGAG CATCTTCTCC 
TATTATGATA ACTCGACTAT GGTCACCGGG AATGCTACCA GAGACCTGAC ACTTCATCAG 
ACCGCCACAC AGCACATGGT GACCAACGCG TCCGCTGTTC CTTCCGACTG TCCCAGTGAA 
GACAAAGACC TCCTGAATGA AAACGTGCAA GTTGGTCTGT TGTTTGCCTC GAAAGCCACC 
GTCCAGCTCA TCACCAACCC TTTCATAGGA CTACTGACCA ACAGAATTGG CTATCCAATT 
CCCATATTTG CGGGATTCTG CATCATGTTT GTCTCAACAA TTATGTTTGC CTTCTCCAGC 
AGCTATGCCT TCCTGCTGAT TGCCAGGTCG CTGCAGGGCA TCGGCTCGTC CTGCTCCTCT 
GTGGCTGGGA TGGGCATGCT TGCCAGTGTC TACACAGATG ATGAAGAGAG AGGCAACGTC 
ATGGGAATCG CCTTGGGAGG CCTGGCCATG GGGGTCTTAG TGGGCCCCCC CTTCGGGAGT 
GTGCTCTATG AGTTTGTGGG GAAGACGGCT CCGTTCCTGG TGCTGGCCGC CCTGGTACTC 
TTGGATGGAG CTATTCAGCT CTTTGTGCTC CAGCCGTCCC GGGTGCAGCC AGAGAGTCAG 
AAGGGGACAC CCCTAACCAC GCTGCTGAAG GACCCGTACA TCCTCATTGC TGCAGGCTCC 
ATCTGCTTTG CAAACATGGG CATCGCCATG CTGGAGCCAG CCCTGCCCAT CTGGATGATG 
GAGACCATGT GTTCCCGAAA GTGGCAGCTG GGCGTTGCCT TCTTGCCAGC TAGTATCTCT 
TATCTCATTG GAACCAATAT TTTTGGGATA CTTGCACACA AAATGGGGAG GTGGCTTTGT 
GCTCTTCTGG GAATGATAAT TGTTGGAGTC AGCATTTTAT GTATTCCATT TGCAAAAAAC 
ATTTATGGAC TCATAGCTCC GAACTTTGGA GTTGGTTTTG CAATTGGAAT GGTGGATTCG 
TCAATGATGC CTATCATGGG CTACCTCGTA GACCTGCGGC ACGTGTCCGT CTATGGGAGT 
GTGTACGCCA TTGCGGATGT GGCATTTTGT ATGGGGTATG CTATAGGTCC TTCTGCTGGT 
GGTGCTATTG CAAAGGCAAT TGGATTTCCA TGGCTCATGA CAATTATTGG GATAATTGAT 
ATTCTTTTTG CCCCTCTCTG CTTTTTTCTT CGAAGTCCAC CTGCCAAAGA AGAAAAAATG 
GCTATTCTCA TGGATCACAA CTGCCCTATT AAAACAAAAA TGTACACTCA GAATAATATC 
CAGTCATATC CGATAGGTGA AGATGAAGAA TCTGAAAGTG ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLC18A2 ( NM_003054.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_003045.2 Homo sapiens solute carrier family 18 member A2 (SLC18A2), mRNA.

Price & Availability↑

CloneID	OHu10952
Clone ID Related Accession (Same CDS sequence)	NM_003054.4 , NM_003054.6
Accession Version	NM_003054.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1545bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	synaptic vesicular amine transporter
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB458870.1, L23205.1, AL391988.14 and BQ416859.1. On Nov 23, 2018 this sequence version replaced NM_003054.5. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.68719.1, SRR1803615.245761.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000644641.2/ ENSP00000496339.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCCTGA GCGAGCTGGC GCTGGTCCGC TGGCTGCAGG AGAGCCGCCG CTCGCGGAAG 
CTCATCCTGT TCATCGTGTT CCTGGCGCTG CTGCTGGACA ACATGCTGCT CACTGTCGTG 
GTCCCCATCA TCCCAAGTTA TCTGTACAGC ATTAAGCATG AGAAGAATGC TACAGAAATC 
CAGACGGCCA GGCCAGTGCA CACTGCCTCC ATCTCAGACA GCTTCCAGAG CATCTTCTCC 
TATTATGATA ACTCGACTAT GGTCACCGGG AATGCTACCA GAGACCTGAC ACTTCATCAG 
ACCGCCACAC AGCACATGGT GACCAACGCG TCCGCTGTTC CTTCCGACTG TCCCAGTGAA 
GACAAAGACC TCCTGAATGA AAACGTGCAA GTTGGTCTGT TGTTTGCCTC GAAAGCCACC 
GTCCAGCTCA TCACCAACCC TTTCATAGGA CTACTGACCA ACAGAATTGG CTATCCAATT 
CCCATATTTG CGGGATTCTG CATCATGTTT GTCTCAACAA TTATGTTTGC CTTCTCCAGC 
AGCTATGCCT TCCTGCTGAT TGCCAGGTCG CTGCAGGGCA TCGGCTCGTC CTGCTCCTCT 
GTGGCTGGGA TGGGCATGCT TGCCAGTGTC TACACAGATG ATGAAGAGAG AGGCAACGTC 
ATGGGAATCG CCTTGGGAGG CCTGGCCATG GGGGTCTTAG TGGGCCCCCC CTTCGGGAGT 
GTGCTCTATG AGTTTGTGGG GAAGACGGCT CCGTTCCTGG TGCTGGCCGC CCTGGTACTC 
TTGGATGGAG CTATTCAGCT CTTTGTGCTC CAGCCGTCCC GGGTGCAGCC AGAGAGTCAG 
AAGGGGACAC CCCTAACCAC GCTGCTGAAG GACCCGTACA TCCTCATTGC TGCAGGCTCC 
ATCTGCTTTG CAAACATGGG CATCGCCATG CTGGAGCCAG CCCTGCCCAT CTGGATGATG 
GAGACCATGT GTTCCCGAAA GTGGCAGCTG GGCGTTGCCT TCTTGCCAGC TAGTATCTCT 
TATCTCATTG GAACCAATAT TTTTGGGATA CTTGCACACA AAATGGGGAG GTGGCTTTGT 
GCTCTTCTGG GAATGATAAT TGTTGGAGTC AGCATTTTAT GTATTCCATT TGCAAAAAAC 
ATTTATGGAC TCATAGCTCC GAACTTTGGA GTTGGTTTTG CAATTGGAAT GGTGGATTCG 
TCAATGATGC CTATCATGGG CTACCTCGTA GACCTGCGGC ACGTGTCCGT CTATGGGAGT 
GTGTACGCCA TTGCGGATGT GGCATTTTGT ATGGGGTATG CTATAGGTCC TTCTGCTGGT 
GGTGCTATTG CAAAGGCAAT TGGATTTCCA TGGCTCATGA CAATTATTGG GATAATTGAT 
ATTCTTTTTG CCCCTCTCTG CTTTTTTCTT CGAAGTCCAC CTGCCAAAGA AGAAAAAATG 
GCTATTCTCA TGGATCACAA CTGCCCTATT AAAACAAAAA TGTACACTCA GAATAATATC 
CAGTCATATC CGATAGGTGA AGATGAAGAA TCTGAAAGTG ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003045.2
CDS	123..1667
Translation	MALSELALVRWLQESRRSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNATEIQTARPVHTASISDSFQSIFSYYDNSTMVTGNATRDLTLHQTATQHMVTNASAVPSDCPSEDKDLLNENVQVGLLFASKATVQLITNPFIGLLTNRIGYPIPIFAGFCIMFVSTIMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGNVMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMIIVGVSILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDILFAPLCFFLRSPPAKEEKMAILMDHNCPIKTKMYTQNNIQSYPIGEDEESESD

Target ORF information:

RefSeq Version	NM_003054.6
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 18 member A2 (SLC18A2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003054.6

ORF Insert Sequence:

ATGGCCCTGA GCGAGCTGGC GCTGGTCCGC TGGCTGCAGG AGAGCCGCCG CTCGCGGAAG 
CTCATCCTGT TCATCGTGTT CCTGGCGCTG CTGCTGGACA ACATGCTGCT CACTGTCGTG 
GTCCCCATCA TCCCAAGTTA TCTGTACAGC ATTAAGCATG AGAAGAATGC TACAGAAATC 
CAGACGGCCA GGCCAGTGCA CACTGCCTCC ATCTCAGACA GCTTCCAGAG CATCTTCTCC 
TATTATGATA ACTCGACTAT GGTCACCGGG AATGCTACCA GAGACCTGAC ACTTCATCAG 
ACCGCCACAC AGCACATGGT GACCAACGCG TCCGCTGTTC CTTCCGACTG TCCCAGTGAA 
GACAAAGACC TCCTGAATGA AAACGTGCAA GTTGGTCTGT TGTTTGCCTC GAAAGCCACC 
GTCCAGCTCA TCACCAACCC TTTCATAGGA CTACTGACCA ACAGAATTGG CTATCCAATT 
CCCATATTTG CGGGATTCTG CATCATGTTT GTCTCAACAA TTATGTTTGC CTTCTCCAGC 
AGCTATGCCT TCCTGCTGAT TGCCAGGTCG CTGCAGGGCA TCGGCTCGTC CTGCTCCTCT 
GTGGCTGGGA TGGGCATGCT TGCCAGTGTC TACACAGATG ATGAAGAGAG AGGCAACGTC 
ATGGGAATCG CCTTGGGAGG CCTGGCCATG GGGGTCTTAG TGGGCCCCCC CTTCGGGAGT 
GTGCTCTATG AGTTTGTGGG GAAGACGGCT CCGTTCCTGG TGCTGGCCGC CCTGGTACTC 
TTGGATGGAG CTATTCAGCT CTTTGTGCTC CAGCCGTCCC GGGTGCAGCC AGAGAGTCAG 
AAGGGGACAC CCCTAACCAC GCTGCTGAAG GACCCGTACA TCCTCATTGC TGCAGGCTCC 
ATCTGCTTTG CAAACATGGG CATCGCCATG CTGGAGCCAG CCCTGCCCAT CTGGATGATG 
GAGACCATGT GTTCCCGAAA GTGGCAGCTG GGCGTTGCCT TCTTGCCAGC TAGTATCTCT 
TATCTCATTG GAACCAATAT TTTTGGGATA CTTGCACACA AAATGGGGAG GTGGCTTTGT 
GCTCTTCTGG GAATGATAAT TGTTGGAGTC AGCATTTTAT GTATTCCATT TGCAAAAAAC 
ATTTATGGAC TCATAGCTCC GAACTTTGGA GTTGGTTTTG CAATTGGAAT GGTGGATTCG 
TCAATGATGC CTATCATGGG CTACCTCGTA GACCTGCGGC ACGTGTCCGT CTATGGGAGT 
GTGTACGCCA TTGCGGATGT GGCATTTTGT ATGGGGTATG CTATAGGTCC TTCTGCTGGT 
GGTGCTATTG CAAAGGCAAT TGGATTTCCA TGGCTCATGA CAATTATTGG GATAATTGAT 
ATTCTTTTTG CCCCTCTCTG CTTTTTTCTT CGAAGTCCAC CTGCCAAAGA AGAAAAAATG 
GCTATTCTCA TGGATCACAA CTGCCCTATT AAAACAAAAA TGTACACTCA GAATAATATC 
CAGTCATATC CGATAGGTGA AGATGAAGAA TCTGAAAGTG ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Association analysis of polymorphisms in VMAT2 and TMEM106B genes for Parkinson's disease, amyotrophic lateral sclerosis and multiple system atrophy.
Journal of the neurological sciences37765-71(2017 Jun)
Hu T,Chen Y,Ou R,Wei Q,Cao B,Zhao B,Wu Y,Song W,Chen X,Shang HF

Genetic variations in the 3'-untranslated region of SLC18A2 are associated with serum FSH concentration in polycystic ovary syndrome patients and regulate gene expression in vitro.
Human reproduction (Oxford, England)31(9)2150-7(2016 Sep)
Li Q,Yan Z,Kuang Y,Zhou X,Jin L,He L,Sun X,Tao T,Wang L

hVMAT2: A Target of Individualized Medication for Parkinson's Disease.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics13(3)623-34(2016 07)
Xiong N,Li N,Martin E,Yu J,Li J,Liu J,Lee DY,Isacson O,Vance J,Qing H,Wang T,Lin Z

Large-scale evaluation of SLC18A2 in prostate cancer reveals diagnostic and prognostic biomarker potential at three molecular levels.
Molecular oncology10(6)825-37(2016 06)
Haldrup C,Lynnerup AS,Storebjerg TM,Vang S,Wild P,Visakorpi T,Arsov C,Schulz WA,Lindberg J,Gr?nberg H,Egevad L,Borre M,?rntoft TF,H?yer S,S?rensen KD

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SLC18A2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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