H3C13 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	H3C13
Entrez Gene ID	653604
Full Name	histone cluster 2 H3 family member d
General protein information	Preferred Names histone cluster 2 H3 family member d Names histone H3.2 histone 2, H3d histone cluster 2, H3d
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q21.2
Summary	Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. [provided by RefSeq, Aug 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001123375.2	NP_001116847.1	histone H3.2
NM_001123375.3	NP_001116847.1	histone H3.2

Pathways from BioSystems

Homologies

	LOC696204	XP_001084245.1
Bos taurus (cattle)	LOC531990	XP_002685546.1
Mus musculus (house mouse)	Hist1h3c	NP_783584.1
Gallus gallus (chicken)	LOC770022	XP_001233028.1
Pan troglodytes (chimpanzee)	LOC746430	XP_003949576.1
Rattus norvegicus (Norway rat)	LOC684762	XP_006254043.1
Xenopus tropicalis (tropical clawed frog)	LOC100495338	XP_002942339.1
Homo sapiens (human)	HIST2H3D	NP_001116847.1
Danio rerio (zebrafish)	LOC564732	XP_003198934.1
Drosophila melanogaster (fruit fly)	His3:CG33851	NP_001027363.1

Gene Ontology
Bibliography

Related articles in PubMed

A unique binding mode enables MCM2 to chaperone histones H3-H4 at replication forks.
Huang H, Str?mme CB, Saredi G, H?dl M, Strandsby A, Gonz?lez-Aguilera C, Chen S, Groth A, Patel DJ
Nature structural & molecular biology22(8)618-26(2015 Aug)

Human tNASP promotes in vitro nucleosome assembly with histone H3.3.
Kato D, Osakabe A, Tachiwana H, Tanaka H, Kurumizaka H
Biochemistry54(5)1171-9(2015 Feb)

DAXX envelops a histone H3.3-H4 dimer for H3.3-specific recognition.
Els?sser SJ, Huang H, Lewis PW, Chin JW, Allis CD, Patel DJ
Nature491(7425)560-5(2012 Nov)

Structures of human nucleosomes containing major histone H3 variants.
Tachiwana H, Osakabe A, Shiga T, Miya Y, Kimura H, Kagawa W, Kurumizaka H
Acta crystallographica. Section D, Biological crystallography67(Pt 6)578-83(2011 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following H3C13 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the H3C13 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu14786	NM_001123375.3 Latest version!	Homo sapiens H3 clustered histone 13 (H3C13), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu14786	NM_001123375.2	Homo sapiens histone cluster 2 H3 family member d (HIST2H3D), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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2-4 Clone	40% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

H3C13 ( NM_001123375.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001116847.1 Homo sapiens histone cluster 2 H3 family member d (HIST2H3D), mRNA.

Price & Availability↑

CloneID	OHu14786
Clone ID Related Accession (Same CDS sequence)	NM_001123375.2 , NM_001123375.3
Accession Version	NM_001123375.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 411bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-07
Organism	Homo sapiens(human)
Product	histone H3.2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC239868.2. On Aug 27, 2010 this sequence version replaced NM_001123375.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCCGTA CTAAGCAGAC TGCCCGCAAG TCGACCGGCG GCAAGGCCCC GAGGAAGCAG 
CTGGCTACCA AAGCGGCCCG CAAGAGCGCG CCGGCCACGG GCGGGGTGAA GAAGCCGCAC 
CGCTACCGGC CCGGCACCGT GGCTCTGCGG GAGATCCGGC GCTACCAGAA GTCTACGGAG 
CTGCTGATCC GCAAGCTGCC CTTCCAGCGG CTGGTACGCG AGATCGCGCA GGACTTTAAG 
ACGGACCTGC GCTTCCAGAG CTCGGCCGTG ATGGCGCTGC AGGAGGCCAG CGAGGCCTAC 
CTGGTGGGGC TGTTCGAAGA CACGAACCTG TGCGCCATCC ATGCCAAGCG CGTGACCATC 
ATGCCCAAGG ACATCCAGTT GGCCCGCCGC ATCCGCGGGG AGCGGGCCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001116847.1
CDS	1..411
Translation	MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA

Target ORF information:

RefSeq Version	NM_001123375.2
Organism	Homo sapiens(human)
Definition	Homo sapiens histone cluster 2 H3 family member d (HIST2H3D), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001123375.2

ORF Insert Sequence:

ATGGCCCGTA CTAAGCAGAC TGCCCGCAAG TCGACCGGCG GCAAGGCCCC GAGGAAGCAG 
CTGGCTACCA AAGCGGCCCG CAAGAGCGCG CCGGCCACGG GCGGGGTGAA GAAGCCGCAC 
CGCTACCGGC CCGGCACCGT GGCTCTGCGG GAGATCCGGC GCTACCAGAA GTCTACGGAG 
CTGCTGATCC GCAAGCTGCC CTTCCAGCGG CTGGTACGCG AGATCGCGCA GGACTTTAAG 
ACGGACCTGC GCTTCCAGAG CTCGGCCGTG ATGGCGCTGC AGGAGGCCAG CGAGGCCTAC 
CTGGTGGGGC TGTTCGAAGA CACGAACCTG TGCGCCATCC ATGCCAAGCG CGTGACCATC 
ATGCCCAAGG ACATCCAGTT GGCCCGCCGC ATCCGCGGGG AGCGGGCCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

H3C13 ( NM_001123375.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001116847.1 Homo sapiens H3 clustered histone 13 (H3C13), mRNA.

Price & Availability↑

CloneID	OHu14786
Clone ID Related Accession (Same CDS sequence)	NM_001123375.2 , NM_001123375.3
Accession Version	NM_001123375.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 411bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Homo sapiens(human)
Product	histone H3.2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC239868.2. On Dec 3, 2019 this sequence version replaced NM_001123375.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCCGTA CTAAGCAGAC TGCCCGCAAG TCGACCGGCG GCAAGGCCCC GAGGAAGCAG 
CTGGCTACCA AAGCGGCCCG CAAGAGCGCG CCGGCCACGG GCGGGGTGAA GAAGCCGCAC 
CGCTACCGGC CCGGCACCGT GGCTCTGCGG GAGATCCGGC GCTACCAGAA GTCTACGGAG 
CTGCTGATCC GCAAGCTGCC CTTCCAGCGG CTGGTACGCG AGATCGCGCA GGACTTTAAG 
ACGGACCTGC GCTTCCAGAG CTCGGCCGTG ATGGCGCTGC AGGAGGCCAG CGAGGCCTAC 
CTGGTGGGGC TGTTCGAAGA CACGAACCTG TGCGCCATCC ATGCCAAGCG CGTGACCATC 
ATGCCCAAGG ACATCCAGTT GGCCCGCCGC ATCCGCGGGG AGCGGGCCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001116847.1
CDS	13..423
Translation	MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA

Target ORF information:

RefSeq Version	NM_001123375.3
Organism	Homo sapiens(human)
Definition	Homo sapiens H3 clustered histone 13 (H3C13), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001123375.3

ORF Insert Sequence:

ATGGCCCGTA CTAAGCAGAC TGCCCGCAAG TCGACCGGCG GCAAGGCCCC GAGGAAGCAG 
CTGGCTACCA AAGCGGCCCG CAAGAGCGCG CCGGCCACGG GCGGGGTGAA GAAGCCGCAC 
CGCTACCGGC CCGGCACCGT GGCTCTGCGG GAGATCCGGC GCTACCAGAA GTCTACGGAG 
CTGCTGATCC GCAAGCTGCC CTTCCAGCGG CTGGTACGCG AGATCGCGCA GGACTTTAAG 
ACGGACCTGC GCTTCCAGAG CTCGGCCGTG ATGGCGCTGC AGGAGGCCAG CGAGGCCTAC 
CTGGTGGGGC TGTTCGAAGA CACGAACCTG TGCGCCATCC ATGCCAAGCG CGTGACCATC 
ATGCCCAAGG ACATCCAGTT GGCCCGCCGC ATCCGCGGGG AGCGGGCCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A unique binding mode enables MCM2 to chaperone histones H3-H4 at replication forks.
Nature structural & molecular biology22(8)618-26(2015 Aug)
Huang H,Str?mme CB,Saredi G,H?dl M,Strandsby A,Gonz?lez-Aguilera C,Chen S,Groth A,Patel DJ

Human tNASP promotes in vitro nucleosome assembly with histone H3.3.
Biochemistry54(5)1171-9(2015 Feb)
Kato D,Osakabe A,Tachiwana H,Tanaka H,Kurumizaka H

DAXX envelops a histone H3.3-H4 dimer for H3.3-specific recognition.
Nature491(7425)560-5(2012 Nov)
Els?sser SJ,Huang H,Lewis PW,Chin JW,Allis CD,Patel DJ

Structures of human nucleosomes containing major histone H3 variants.
Acta crystallographica. Section D, Biological crystallography67(Pt 6)578-83(2011 Jun)
Tachiwana H,Osakabe A,Shiga T,Miya Y,Kimura H,Kagawa W,Kurumizaka H

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H3C13 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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