SLC6A8 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SLC6A8
Entrez Gene ID	6535
Full Name	solute carrier family 6 member 8
Synonyms	CCDS1,CRT,CRTR,CT1,CTR5
General protein information	Preferred Names solute carrier family 6 member 8 Names sodium- and chloride-dependent creatine transporter 1 creatine transporter 1 creatine transporter SLC6A8 variant D solute carrier family 6 (neurotransmitter transporter), member 8 solute carrier family 6 (neurotransmitter transporter, creatine), member 8
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq28
Summary	The protein encoded by this gene is a plasma membrane protein whose function is to transport creatine into and out of cells. Defects in this gene can result in X-linked creatine deficiency syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008].
Disorder MIM:	300036
Disorder Html:	Cerebral creatine deficiency syndrome 1, 300352 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001142806.1	NP_001136278.1	sodium- and chloride-dependent creatine transporter 1 isoform 3
NM_005629.4	NP_005620.1	sodium- and chloride-dependent creatine transporter 1 isoform 1
NM_001142805.1	NP_001136277.1	sodium- and chloride-dependent creatine transporter 1 isoform 2
NM_005629.3	NP_005620.1	sodium- and chloride-dependent creatine transporter 1 isoform 1
NM_001142805.2	NP_001136277.1	sodium- and chloride-dependent creatine transporter 1 isoform 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	SLC6A8	XP_529227.4
Danio rerio (zebrafish)	slc6a8	XP_695932.1
	SLC6A8	XP_001086826.2
Xenopus tropicalis (tropical clawed frog)	LOC100489909	XP_004916750.1
Rattus norvegicus (Norway rat)	Slc6a8	NP_059044.1
Bos taurus (cattle)	SLC6A8	NP_777036.1
Mus musculus (house mouse)	Slc6a8	NP_001136281.1
Homo sapiens (human)	SLC6A8	NP_005620.1
Canis lupus familiaris (dog)	SLC6A8	XP_005642051.1

Gene Ontology
Bibliography

Related articles in PubMed

Laboratory diagnosis of creatine deficiency syndromes: a technical standard and guideline of the American College of Medical Genetics and Genomics.
Sharer JD, Bodamer O, Longo N, Tortorelli S, Wamelink MM, Young S
Genetics in medicine : official journal of the American College of Medical Genetics19(2)256-263(2017 Feb)

Abnormal N-Glycosylation of a Novel Missense Creatine Transporter Mutant, G561R, Associated with Cerebral Creatine Deficiency Syndromes Alters Transporter Activity and Localization.
Uemura T, Ito S, Ohta Y, Tachikawa M, Wada T, Terasaki T, Ohtsuki S
Biological & pharmaceutical bulletin40(1)49-55(2017)

Creatine biosynthesis and transport in health and disease.
Joncquel-Chevalier Curt M, Voicu PM, Fontaine M, Dessein AF, Porchet N, Mention-Mulliez K, Dobbelaere D, Soto-Ares G, Cheillan D, Vamecq J
Biochimie119146-65(2015 Dec)

Estimated carrier frequency of creatine transporter deficiency in females in the general population using functional characterization of novel missense variants in the SLC6A8 gene.
DesRoches CL, Patel J, Wang P, Minassian B, Salomons GS, Marshall CR, Mercimek-Mahmutoglu S
Gene565(2)187-91(2015 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Measurements of creatine and guanidinoacetate in plasma are recommended for the diagnosis of AGAT and GAMT deficiency.Definitive confirmation of the diagnosis requires DNA sequencing of the appropriate gene and (if molecular analysis is ambiguous) measurement of AGAT or GAMT enzyme activity or of CRTR-mediated transport
Title: Laboratory diagnosis of creatine deficiency syndromes: a technical standard and guideline of the American College of Medical Genetics and Genomics.

The present study demonstrated that a novel CRT missense mutation in exon 12 of the SLC6A8 gene (c.1681G>C; p.G561R) causes suppression of creatine transport activity
Title: Abnormal N-Glycosylation of a Novel Missense Creatine Transporter Mutant, G561R, Associated with Cerebral Creatine Deficiency Syndromes Alters Transporter Activity and Localization.

Data suggest that a specific plasma membrane transporter, creatine transporter (SLC6A8), enables cells to incorporate creatine; creatine uptake is controlled by AMP-activated protein kinase, a ubiquitous sensor of energy depletion. [REVIEW]
Title: Creatine biosynthesis and transport in health and disease.

The SLC6A8 c.1654G>T (p.Val552Leu) variant showed low residual creatine uptake activity of 35% of wild type transfected HeLa cells.
Title: Estimated carrier frequency of creatine transporter deficiency in females in the general population using functional characterization of novel missense variants in the SLC6A8 gene.

Both SPAK and OSR1 are negative regulators of the creatine transporter SLC6A8
Title: Negative regulation of the creatine transporter SLC6A8 by SPAK and OSR1.

The following SLC6A8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLC6A8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu27778	NM_005629.4 Latest version!	Homo sapiens solute carrier family 6 member 8 (SLC6A8), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu27780	NM_001142806.1 Latest version!	Homo sapiens solute carrier family 6 member 8 (SLC6A8), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu27787	NM_001142805.2 Latest version!	Homo sapiens solute carrier family 6 member 8 (SLC6A8), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
View Old Accession Versions >>
OHu27778	NM_005629.3	Homo sapiens solute carrier family 6 member 8 (SLC6A8), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu27787	NM_001142805.1	Homo sapiens solute carrier family 6 member 8 (SLC6A8), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SLC6A8 ( NM_005629.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005620.1 Homo sapiens solute carrier family 6 member 8 (SLC6A8), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu27778
Clone ID Related Accession (Same CDS sequence)	NM_005629.4 , NM_005629.3
Accession Version	NM_005629.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1908bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	sodium- and chloride-dependent creatine transporter 1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U52111.3, BC081558.1, L31409.1, CX788315.1 and BE207407.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_005629.3. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L31409.1, BC081558.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000253122.10/ ENSP00000253122.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGAAGA AGAGCGCCGA GAACGGCATC TATAGCGTGT CCGGCGACGA GAAGAAGGGC 
CCCCTCATCG CGCCCGGGCC CGACGGGGCC CCGGCCAAGG GCGACGGCCC CGTGGGCCTG 
GGGACACCCG GCGGCCGCCT GGCCGTGCCG CCGCGCGAGA CCTGGACGCG CCAGATGGAC 
TTCATCATGT CGTGCGTGGG CTTCGCCGTG GGCTTGGGCA ACGTGTGGCG CTTCCCCTAC 
CTGTGCTACA AGAACGGCGG AGGTGTGTTC CTTATTCCCT ACGTCCTGAT CGCCCTGGTT 
GGAGGAATCC CCATTTTCTT CTTAGAGATC TCGCTGGGCC AGTTCATGAA GGCCGGCAGC 
ATCAATGTCT GGAACATCTG TCCCCTGTTC AAAGGCCTGG GCTACGCCTC CATGGTGATC 
GTCTTCTACT GCAACACCTA CTACATCATG GTGCTGGCCT GGGGCTTCTA TTACCTGGTC 
AAGTCCTTTA CCACCACGCT GCCCTGGGCC ACATGTGGCC ACACCTGGAA CACTCCCGAC 
TGCGTGGAGA TCTTCCGCCA TGAAGACTGT GCCAATGCCA GCCTGGCCAA CCTCACCTGT 
GACCAGCTTG CTGACCGCCG GTCCCCTGTC ATCGAGTTCT GGGAGAACAA AGTCTTGAGG 
CTGTCTGGGG GACTGGAGGT GCCAGGGGCC CTCAACTGGG AGGTGACCCT TTGTCTGCTG 
GCCTGCTGGG TGCTGGTCTA CTTCTGTGTC TGGAAGGGGG TCAAATCCAC GGGAAAGATC 
GTGTACTTCA CTGCTACATT CCCCTACGTG GTCCTGGTCG TGCTGCTGGT GCGTGGAGTG 
CTGCTGCCTG GCGCCCTGGA TGGCATCATT TACTATCTCA AGCCTGACTG GTCAAAGCTG 
GGGTCCCCTC AGGTGTGGAT AGATGCGGGG ACCCAGATTT TCTTTTCTTA CGCCATTGGC 
CTGGGGGCCC TCACAGCCCT GGGCAGCTAC AACCGCTTCA ACAACAACTG CTACAAGGAC 
GCCATCATCC TGGCTCTCAT CAACAGTGGG ACCAGCTTCT TTGCTGGCTT CGTGGTCTTC 
TCCATCCTGG GCTTCATGGC TGCAGAGCAG GGCGTGCACA TCTCCAAGGT GGCAGAGTCA 
GGGCCGGGCC TGGCCTTCAT CGCCTACCCG CGGGCTGTCA CGCTGATGCC AGTGGCCCCA 
CTCTGGGCTG CCCTGTTCTT CTTCATGCTG TTGCTGCTTG GTCTCGACAG CCAGTTTGTA 
GGTGTGGAGG GCTTCATCAC CGGCCTCCTC GACCTCCTCC CGGCCTCCTA CTACTTCCGT 
TTCCAAAGGG AGATCTCTGT GGCCCTCTGT TGTGCCCTCT GCTTTGTCAT CGATCTCTCC 
ATGGTGACTG ATGGCGGGAT GTACGTCTTC CAGCTGTTTG ACTACTACTC GGCCAGCGGC 
ACCACCCTGC TCTGGCAGGC CTTTTGGGAG TGCGTGGTGG TGGCCTGGGT GTACGGAGCT 
GACCGCTTCA TGGACGACAT TGCCTGTATG ATCGGGTACC GACCTTGCCC CTGGATGAAA 
TGGTGCTGGT CCTTCTTCAC CCCGCTGGTC TGCATGGGCA TCTTCATCTT CAACGTTGTG 
TACTACGAGC CGCTGGTCTA CAACAACACC TACGTGTACC CGTGGTGGGG TGAGGCCATG 
GGCTGGGCCT TCGCCCTGTC CTCCATGCTG TGCGTGCCGC TGCACCTCCT GGGCTGCCTC 
CTCAGGGCCA AGGGCACCAT GGCTGAGCGC TGGCAGCACC TGACCCAGCC CATCTGGGGC 
CTCCACCACT TGGAGTACCG AGCTCAGGAC GCAGATGTCA GGGGCCTGAC CACCCTGACC 
CCAGTGTCCG AGAGCAGCAA GGTCGTCGTG GTGGAGAGTG TCATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005620.1
CDS	650..2557
Translation	MAKKSAENGIYSVSGDEKKGPLIAPGPDGAPAKGDGPVGLGTPGGRLAVPPRETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFMKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFAGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQPIWGLHHLEYRAQDADVRGLTTLTPVSESSKVVVVESVM

Target ORF information:

RefSeq Version	NM_005629.4
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 6 member 8 (SLC6A8), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005629.4

ORF Insert Sequence:

ATGGCGAAGA AGAGCGCCGA GAACGGCATC TATAGCGTGT CCGGCGACGA GAAGAAGGGC 
CCCCTCATCG CGCCCGGGCC CGACGGGGCC CCGGCCAAGG GCGACGGCCC CGTGGGCCTG 
GGGACACCCG GCGGCCGCCT GGCCGTGCCG CCGCGCGAGA CCTGGACGCG CCAGATGGAC 
TTCATCATGT CGTGCGTGGG CTTCGCCGTG GGCTTGGGCA ACGTGTGGCG CTTCCCCTAC 
CTGTGCTACA AGAACGGCGG AGGTGTGTTC CTTATTCCCT ACGTCCTGAT CGCCCTGGTT 
GGAGGAATCC CCATTTTCTT CTTAGAGATC TCGCTGGGCC AGTTCATGAA GGCCGGCAGC 
ATCAATGTCT GGAACATCTG TCCCCTGTTC AAAGGCCTGG GCTACGCCTC CATGGTGATC 
GTCTTCTACT GCAACACCTA CTACATCATG GTGCTGGCCT GGGGCTTCTA TTACCTGGTC 
AAGTCCTTTA CCACCACGCT GCCCTGGGCC ACATGTGGCC ACACCTGGAA CACTCCCGAC 
TGCGTGGAGA TCTTCCGCCA TGAAGACTGT GCCAATGCCA GCCTGGCCAA CCTCACCTGT 
GACCAGCTTG CTGACCGCCG GTCCCCTGTC ATCGAGTTCT GGGAGAACAA AGTCTTGAGG 
CTGTCTGGGG GACTGGAGGT GCCAGGGGCC CTCAACTGGG AGGTGACCCT TTGTCTGCTG 
GCCTGCTGGG TGCTGGTCTA CTTCTGTGTC TGGAAGGGGG TCAAATCCAC GGGAAAGATC 
GTGTACTTCA CTGCTACATT CCCCTACGTG GTCCTGGTCG TGCTGCTGGT GCGTGGAGTG 
CTGCTGCCTG GCGCCCTGGA TGGCATCATT TACTATCTCA AGCCTGACTG GTCAAAGCTG 
GGGTCCCCTC AGGTGTGGAT AGATGCGGGG ACCCAGATTT TCTTTTCTTA CGCCATTGGC 
CTGGGGGCCC TCACAGCCCT GGGCAGCTAC AACCGCTTCA ACAACAACTG CTACAAGGAC 
GCCATCATCC TGGCTCTCAT CAACAGTGGG ACCAGCTTCT TTGCTGGCTT CGTGGTCTTC 
TCCATCCTGG GCTTCATGGC TGCAGAGCAG GGCGTGCACA TCTCCAAGGT GGCAGAGTCA 
GGGCCGGGCC TGGCCTTCAT CGCCTACCCG CGGGCTGTCA CGCTGATGCC AGTGGCCCCA 
CTCTGGGCTG CCCTGTTCTT CTTCATGCTG TTGCTGCTTG GTCTCGACAG CCAGTTTGTA 
GGTGTGGAGG GCTTCATCAC CGGCCTCCTC GACCTCCTCC CGGCCTCCTA CTACTTCCGT 
TTCCAAAGGG AGATCTCTGT GGCCCTCTGT TGTGCCCTCT GCTTTGTCAT CGATCTCTCC 
ATGGTGACTG ATGGCGGGAT GTACGTCTTC CAGCTGTTTG ACTACTACTC GGCCAGCGGC 
ACCACCCTGC TCTGGCAGGC CTTTTGGGAG TGCGTGGTGG TGGCCTGGGT GTACGGAGCT 
GACCGCTTCA TGGACGACAT TGCCTGTATG ATCGGGTACC GACCTTGCCC CTGGATGAAA 
TGGTGCTGGT CCTTCTTCAC CCCGCTGGTC TGCATGGGCA TCTTCATCTT CAACGTTGTG 
TACTACGAGC CGCTGGTCTA CAACAACACC TACGTGTACC CGTGGTGGGG TGAGGCCATG 
GGCTGGGCCT TCGCCCTGTC CTCCATGCTG TGCGTGCCGC TGCACCTCCT GGGCTGCCTC 
CTCAGGGCCA AGGGCACCAT GGCTGAGCGC TGGCAGCACC TGACCCAGCC CATCTGGGGC 
CTCCACCACT TGGAGTACCG AGCTCAGGAC GCAGATGTCA GGGGCCTGAC CACCCTGACC 
CCAGTGTCCG AGAGCAGCAA GGTCGTCGTG GTGGAGAGTG TCATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLC6A8 ( NM_005629.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005620.1 Homo sapiens solute carrier family 6 member 8 (SLC6A8), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu27778
Clone ID Related Accession (Same CDS sequence)	NM_005629.4 , NM_005629.3
Accession Version	NM_005629.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1908bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-17
Organism	Homo sapiens(human)
Product	sodium- and chloride-dependent creatine transporter 1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC081558.1, L31409.1, U52111.3, CX788315.1, BE207407.1 and CA424985.1. This sequence is a reference standard in the RefSeqGene project. On Dec 20, 2008 this sequence version replaced NM_005629.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC081558.1, L31409.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGAAGA AGAGCGCCGA GAACGGCATC TATAGCGTGT CCGGCGACGA GAAGAAGGGC 
CCCCTCATCG CGCCCGGGCC CGACGGGGCC CCGGCCAAGG GCGACGGCCC CGTGGGCCTG 
GGGACACCCG GCGGCCGCCT GGCCGTGCCG CCGCGCGAGA CCTGGACGCG CCAGATGGAC 
TTCATCATGT CGTGCGTGGG CTTCGCCGTG GGCTTGGGCA ACGTGTGGCG CTTCCCCTAC 
CTGTGCTACA AGAACGGCGG AGGTGTGTTC CTTATTCCCT ACGTCCTGAT CGCCCTGGTT 
GGAGGAATCC CCATTTTCTT CTTAGAGATC TCGCTGGGCC AGTTCATGAA GGCCGGCAGC 
ATCAATGTCT GGAACATCTG TCCCCTGTTC AAAGGCCTGG GCTACGCCTC CATGGTGATC 
GTCTTCTACT GCAACACCTA CTACATCATG GTGCTGGCCT GGGGCTTCTA TTACCTGGTC 
AAGTCCTTTA CCACCACGCT GCCCTGGGCC ACATGTGGCC ACACCTGGAA CACTCCCGAC 
TGCGTGGAGA TCTTCCGCCA TGAAGACTGT GCCAATGCCA GCCTGGCCAA CCTCACCTGT 
GACCAGCTTG CTGACCGCCG GTCCCCTGTC ATCGAGTTCT GGGAGAACAA AGTCTTGAGG 
CTGTCTGGGG GACTGGAGGT GCCAGGGGCC CTCAACTGGG AGGTGACCCT TTGTCTGCTG 
GCCTGCTGGG TGCTGGTCTA CTTCTGTGTC TGGAAGGGGG TCAAATCCAC GGGAAAGATC 
GTGTACTTCA CTGCTACATT CCCCTACGTG GTCCTGGTCG TGCTGCTGGT GCGTGGAGTG 
CTGCTGCCTG GCGCCCTGGA TGGCATCATT TACTATCTCA AGCCTGACTG GTCAAAGCTG 
GGGTCCCCTC AGGTGTGGAT AGATGCGGGG ACCCAGATTT TCTTTTCTTA CGCCATTGGC 
CTGGGGGCCC TCACAGCCCT GGGCAGCTAC AACCGCTTCA ACAACAACTG CTACAAGGAC 
GCCATCATCC TGGCTCTCAT CAACAGTGGG ACCAGCTTCT TTGCTGGCTT CGTGGTCTTC 
TCCATCCTGG GCTTCATGGC TGCAGAGCAG GGCGTGCACA TCTCCAAGGT GGCAGAGTCA 
GGGCCGGGCC TGGCCTTCAT CGCCTACCCG CGGGCTGTCA CGCTGATGCC AGTGGCCCCA 
CTCTGGGCTG CCCTGTTCTT CTTCATGCTG TTGCTGCTTG GTCTCGACAG CCAGTTTGTA 
GGTGTGGAGG GCTTCATCAC CGGCCTCCTC GACCTCCTCC CGGCCTCCTA CTACTTCCGT 
TTCCAAAGGG AGATCTCTGT GGCCCTCTGT TGTGCCCTCT GCTTTGTCAT CGATCTCTCC 
ATGGTGACTG ATGGCGGGAT GTACGTCTTC CAGCTGTTTG ACTACTACTC GGCCAGCGGC 
ACCACCCTGC TCTGGCAGGC CTTTTGGGAG TGCGTGGTGG TGGCCTGGGT GTACGGAGCT 
GACCGCTTCA TGGACGACAT TGCCTGTATG ATCGGGTACC GACCTTGCCC CTGGATGAAA 
TGGTGCTGGT CCTTCTTCAC CCCGCTGGTC TGCATGGGCA TCTTCATCTT CAACGTTGTG 
TACTACGAGC CGCTGGTCTA CAACAACACC TACGTGTACC CGTGGTGGGG TGAGGCCATG 
GGCTGGGCCT TCGCCCTGTC CTCCATGCTG TGCGTGCCGC TGCACCTCCT GGGCTGCCTC 
CTCAGGGCCA AGGGCACCAT GGCTGAGCGC TGGCAGCACC TGACCCAGCC CATCTGGGGC 
CTCCACCACT TGGAGTACCG AGCTCAGGAC GCAGATGTCA GGGGCCTGAC CACCCTGACC 
CCAGTGTCCG AGAGCAGCAA GGTCGTCGTG GTGGAGAGTG TCATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005620.1
CDS	279..2186
Translation	MAKKSAENGIYSVSGDEKKGPLIAPGPDGAPAKGDGPVGLGTPGGRLAVPPRETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFMKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFAGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQPIWGLHHLEYRAQDADVRGLTTLTPVSESSKVVVVESVM

Target ORF information:

RefSeq Version	NM_005629.3
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 6 member 8 (SLC6A8), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005629.3

ORF Insert Sequence:

ATGGCGAAGA AGAGCGCCGA GAACGGCATC TATAGCGTGT CCGGCGACGA GAAGAAGGGC 
CCCCTCATCG CGCCCGGGCC CGACGGGGCC CCGGCCAAGG GCGACGGCCC CGTGGGCCTG 
GGGACACCCG GCGGCCGCCT GGCCGTGCCG CCGCGCGAGA CCTGGACGCG CCAGATGGAC 
TTCATCATGT CGTGCGTGGG CTTCGCCGTG GGCTTGGGCA ACGTGTGGCG CTTCCCCTAC 
CTGTGCTACA AGAACGGCGG AGGTGTGTTC CTTATTCCCT ACGTCCTGAT CGCCCTGGTT 
GGAGGAATCC CCATTTTCTT CTTAGAGATC TCGCTGGGCC AGTTCATGAA GGCCGGCAGC 
ATCAATGTCT GGAACATCTG TCCCCTGTTC AAAGGCCTGG GCTACGCCTC CATGGTGATC 
GTCTTCTACT GCAACACCTA CTACATCATG GTGCTGGCCT GGGGCTTCTA TTACCTGGTC 
AAGTCCTTTA CCACCACGCT GCCCTGGGCC ACATGTGGCC ACACCTGGAA CACTCCCGAC 
TGCGTGGAGA TCTTCCGCCA TGAAGACTGT GCCAATGCCA GCCTGGCCAA CCTCACCTGT 
GACCAGCTTG CTGACCGCCG GTCCCCTGTC ATCGAGTTCT GGGAGAACAA AGTCTTGAGG 
CTGTCTGGGG GACTGGAGGT GCCAGGGGCC CTCAACTGGG AGGTGACCCT TTGTCTGCTG 
GCCTGCTGGG TGCTGGTCTA CTTCTGTGTC TGGAAGGGGG TCAAATCCAC GGGAAAGATC 
GTGTACTTCA CTGCTACATT CCCCTACGTG GTCCTGGTCG TGCTGCTGGT GCGTGGAGTG 
CTGCTGCCTG GCGCCCTGGA TGGCATCATT TACTATCTCA AGCCTGACTG GTCAAAGCTG 
GGGTCCCCTC AGGTGTGGAT AGATGCGGGG ACCCAGATTT TCTTTTCTTA CGCCATTGGC 
CTGGGGGCCC TCACAGCCCT GGGCAGCTAC AACCGCTTCA ACAACAACTG CTACAAGGAC 
GCCATCATCC TGGCTCTCAT CAACAGTGGG ACCAGCTTCT TTGCTGGCTT CGTGGTCTTC 
TCCATCCTGG GCTTCATGGC TGCAGAGCAG GGCGTGCACA TCTCCAAGGT GGCAGAGTCA 
GGGCCGGGCC TGGCCTTCAT CGCCTACCCG CGGGCTGTCA CGCTGATGCC AGTGGCCCCA 
CTCTGGGCTG CCCTGTTCTT CTTCATGCTG TTGCTGCTTG GTCTCGACAG CCAGTTTGTA 
GGTGTGGAGG GCTTCATCAC CGGCCTCCTC GACCTCCTCC CGGCCTCCTA CTACTTCCGT 
TTCCAAAGGG AGATCTCTGT GGCCCTCTGT TGTGCCCTCT GCTTTGTCAT CGATCTCTCC 
ATGGTGACTG ATGGCGGGAT GTACGTCTTC CAGCTGTTTG ACTACTACTC GGCCAGCGGC 
ACCACCCTGC TCTGGCAGGC CTTTTGGGAG TGCGTGGTGG TGGCCTGGGT GTACGGAGCT 
GACCGCTTCA TGGACGACAT TGCCTGTATG ATCGGGTACC GACCTTGCCC CTGGATGAAA 
TGGTGCTGGT CCTTCTTCAC CCCGCTGGTC TGCATGGGCA TCTTCATCTT CAACGTTGTG 
TACTACGAGC CGCTGGTCTA CAACAACACC TACGTGTACC CGTGGTGGGG TGAGGCCATG 
GGCTGGGCCT TCGCCCTGTC CTCCATGCTG TGCGTGCCGC TGCACCTCCT GGGCTGCCTC 
CTCAGGGCCA AGGGCACCAT GGCTGAGCGC TGGCAGCACC TGACCCAGCC CATCTGGGGC 
CTCCACCACT TGGAGTACCG AGCTCAGGAC GCAGATGTCA GGGGCCTGAC CACCCTGACC 
CCAGTGTCCG AGAGCAGCAA GGTCGTCGTG GTGGAGAGTG TCATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLC6A8 ( NM_001142806.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001136278.1 Homo sapiens solute carrier family 6 member 8 (SLC6A8), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu27780
Clone ID Related Accession (Same CDS sequence)	NM_001142806.1
Accession Version	NM_001142806.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1563bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Homo sapiens(human)
Product	sodium- and chloride-dependent creatine transporter 1 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK295495.1, U52111.3, BC012355.1, CX788315.1, BE207407.1 and CA424985.1. Transcript Variant: This variant (3) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (3) has a shorter N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK295495.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGGCCG GCAGCATCAA TGTCTGGAAC ATCTGTCCCC TGTTCAAAGG CCTGGGCTAC 
GCCTCCATGG TGATCGTCTT CTACTGCAAC ACCTACTACA TCATGGTGCT GGCCTGGGGC 
TTCTATTACC TGGTCAAGTC CTTTACCACC ACGCTGCCCT GGGCCACATG TGGCCACACC 
TGGAACACTC CCGACTGCGT GGAGATCTTC CGCCATGAAG ACTGTGCCAA TGCCAGCCTG 
GCCAACCTCA CCTGTGACCA GCTTGCTGAC CGCCGGTCCC CTGTCATCGA GTTCTGGGAG 
AACAAAGTCT TGAGGCTGTC TGGGGGACTG GAGGTGCCAG GGGCCCTCAA CTGGGAGGTG 
ACCCTTTGTC TGCTGGCCTG CTGGGTGCTG GTCTACTTCT GTGTCTGGAA GGGGGTCAAA 
TCCACGGGAA AGATCGTGTA CTTCACTGCT ACATTCCCCT ACGTGGTCCT GGTCGTGCTG 
CTGGTGCGTG GAGTGCTGCT GCCTGGCGCC CTGGATGGCA TCATTTACTA TCTCAAGCCT 
GACTGGTCAA AGCTGGGGTC CCCTCAGGTG TGGATAGATG CGGGGACCCA GATTTTCTTT 
TCTTACGCCA TTGGCCTGGG GGCCCTCACA GCCCTGGGCA GCTACAACCG CTTCAACAAC 
AACTGCTACA AGGACGCCAT CATCCTGGCT CTCATCAACA GTGGGACCAG CTTCTTTGCT 
GGCTTCGTGG TCTTCTCCAT CCTGGGCTTC ATGGCTGCAG AGCAGGGCGT GCACATCTCC 
AAGGTGGCAG AGTCAGGGCC GGGCCTGGCC TTCATCGCCT ACCCGCGGGC TGTCACGCTG 
ATGCCAGTGG CCCCACTCTG GGCTGCCCTG TTCTTCTTCA TGCTGTTGCT GCTTGGTCTC 
GACAGCCAGT TTGTAGGTGT GGAGGGCTTC ATCACCGGCC TCCTCGACCT CCTCCCGGCC 
TCCTACTACT TCCGTTTCCA AAGGGAGATC TCTGTGGCCC TCTGTTGTGC CCTCTGCTTT 
GTCATCGATC TCTCCATGGT GACTGATGGC GGGATGTACG TCTTCCAGCT GTTTGACTAC 
TACTCGGCCA GCGGCACCAC CCTGCTCTGG CAGGCCTTTT GGGAGTGCGT GGTGGTGGCC 
TGGGTGTACG GAGCTGACCG CTTCATGGAC GACATTGCCT GTATGATCGG GTACCGACCT 
TGCCCCTGGA TGAAATGGTG CTGGTCCTTC TTCACCCCGC TGGTCTGCAT GGGCATCTTC 
ATCTTCAACG TTGTGTACTA CGAGCCGCTG GTCTACAACA ACACCTACGT GTACCCGTGG 
TGGGGTGAGG CCATGGGCTG GGCCTTCGCC CTGTCCTCCA TGCTGTGCGT GCCGCTGCAC 
CTCCTGGGCT GCCTCCTCAG GGCCAAGGGC ACCATGGCTG AGCGCTGGCA GCACCTGACC 
CAGCCCATCT GGGGCCTCCA CCACTTGGAG TACCGAGCTC AGGACGCAGA TGTCAGGGGC 
CTGACCACCC TGACCCCAGT GTCCGAGAGC AGCAAGGTCG TCGTGGTGGA GAGTGTCATG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001136278.1
CDS	173..1735
Translation	MKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFAGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQPIWGLHHLEYRAQDADVRGLTTLTPVSESSKVVVVESVM

Target ORF information:

RefSeq Version	NM_001142806.1
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 6 member 8 (SLC6A8), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001142806.1

ORF Insert Sequence:

ATGAAGGCCG GCAGCATCAA TGTCTGGAAC ATCTGTCCCC TGTTCAAAGG CCTGGGCTAC 
GCCTCCATGG TGATCGTCTT CTACTGCAAC ACCTACTACA TCATGGTGCT GGCCTGGGGC 
TTCTATTACC TGGTCAAGTC CTTTACCACC ACGCTGCCCT GGGCCACATG TGGCCACACC 
TGGAACACTC CCGACTGCGT GGAGATCTTC CGCCATGAAG ACTGTGCCAA TGCCAGCCTG 
GCCAACCTCA CCTGTGACCA GCTTGCTGAC CGCCGGTCCC CTGTCATCGA GTTCTGGGAG 
AACAAAGTCT TGAGGCTGTC TGGGGGACTG GAGGTGCCAG GGGCCCTCAA CTGGGAGGTG 
ACCCTTTGTC TGCTGGCCTG CTGGGTGCTG GTCTACTTCT GTGTCTGGAA GGGGGTCAAA 
TCCACGGGAA AGATCGTGTA CTTCACTGCT ACATTCCCCT ACGTGGTCCT GGTCGTGCTG 
CTGGTGCGTG GAGTGCTGCT GCCTGGCGCC CTGGATGGCA TCATTTACTA TCTCAAGCCT 
GACTGGTCAA AGCTGGGGTC CCCTCAGGTG TGGATAGATG CGGGGACCCA GATTTTCTTT 
TCTTACGCCA TTGGCCTGGG GGCCCTCACA GCCCTGGGCA GCTACAACCG CTTCAACAAC 
AACTGCTACA AGGACGCCAT CATCCTGGCT CTCATCAACA GTGGGACCAG CTTCTTTGCT 
GGCTTCGTGG TCTTCTCCAT CCTGGGCTTC ATGGCTGCAG AGCAGGGCGT GCACATCTCC 
AAGGTGGCAG AGTCAGGGCC GGGCCTGGCC TTCATCGCCT ACCCGCGGGC TGTCACGCTG 
ATGCCAGTGG CCCCACTCTG GGCTGCCCTG TTCTTCTTCA TGCTGTTGCT GCTTGGTCTC 
GACAGCCAGT TTGTAGGTGT GGAGGGCTTC ATCACCGGCC TCCTCGACCT CCTCCCGGCC 
TCCTACTACT TCCGTTTCCA AAGGGAGATC TCTGTGGCCC TCTGTTGTGC CCTCTGCTTT 
GTCATCGATC TCTCCATGGT GACTGATGGC GGGATGTACG TCTTCCAGCT GTTTGACTAC 
TACTCGGCCA GCGGCACCAC CCTGCTCTGG CAGGCCTTTT GGGAGTGCGT GGTGGTGGCC 
TGGGTGTACG GAGCTGACCG CTTCATGGAC GACATTGCCT GTATGATCGG GTACCGACCT 
TGCCCCTGGA TGAAATGGTG CTGGTCCTTC TTCACCCCGC TGGTCTGCAT GGGCATCTTC 
ATCTTCAACG TTGTGTACTA CGAGCCGCTG GTCTACAACA ACACCTACGT GTACCCGTGG 
TGGGGTGAGG CCATGGGCTG GGCCTTCGCC CTGTCCTCCA TGCTGTGCGT GCCGCTGCAC 
CTCCTGGGCT GCCTCCTCAG GGCCAAGGGC ACCATGGCTG AGCGCTGGCA GCACCTGACC 
CAGCCCATCT GGGGCCTCCA CCACTTGGAG TACCGAGCTC AGGACGCAGA TGTCAGGGGC 
CTGACCACCC TGACCCCAGT GTCCGAGAGC AGCAAGGTCG TCGTGGTGGA GAGTGTCATG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLC6A8 ( NM_001142805.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001136277.1 Homo sapiens solute carrier family 6 member 8 (SLC6A8), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu27787
Clone ID Related Accession (Same CDS sequence)	NM_001142805.1 , NM_001142805.2
Accession Version	NM_001142805.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1878bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-19
Organism	Homo sapiens(human)
Product	sodium- and chloride-dependent creatine transporter 1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC081558.1, L31409.1, AB209704.1, U52111.3, CX788315.1, BE207407.1 and CA424985.1. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (2) lacks a 10-aa segment but has the same N- and C-termini, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB209704.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGAAGA AGAGCGCCGA GAACGGCATC TATAGCGTGT CCGGCGACGA GAAGAAGGGC 
CCCCTCATCG CGCCCGGGCC CGACGGGGCC CCGGCCAAGG GCGACGGCCC CGTGGGCCTG 
GGGACACCCG GCGGCCGCCT GGCCGTGCCG CCGCGCGAGA CCTGGACGCG CCAGATGGAC 
TTCATCATGT CGTGCGTGGG CTTCGCCGTG GGCTTGGGCA ACGTGTGGCG CTTCCCCTAC 
CTGTGCTACA AGAACGGCGG AGGTGTGTTC CTTATTCCCT ACGTCCTGAT CGCCCTGGTT 
GGAGGAATCC CCATTTTCTT CTTAGAGATC TCGCTGGGCC AGTTCATGAA GGCCGGCAGC 
ATCAATGTCT GGAACATCTG TCCCCTGTTC AAAGGCCTGG GCTACGCCTC CATGGTGATC 
GTCTTCTACT GCAACACCTA CTACATCATG GTGCTGGCCT GGGGCTTCTA TTACCTGGTC 
AAGTCCTTTA CCACCACGCT GCCCTGGGCC ACATGTGGCC ACACCTGGAA CACTCCCGAC 
TGCGTGGAGA TCTTCCGCCA TGAAGACTGT GCCAATGCCA GCCTGGCCAA CCTCACCTGT 
GACCAGCTTG CTGACCGCCG GTCCCCTGTC ATCGAGTTCT GGGAGAACAA AGTCTTGAGG 
CTGTCTGGGG GACTGGAGGT GCCAGGGGCC CTCAACTGGG AGGTGACCCT TTGTCTGCTG 
GCCTGCTGGG TGCTGGTCTA CTTCTGTGTC TGGAAGGGGG TCAAATCCAC GGGAAAGATC 
GTGTACTTCA CTGCTACATT CCCCTACGTG GTCCTGGTCG TGCTGCTGGT GCGTGGAGTG 
CTGCTGCCTG GCGCCCTGGA TGGCATCATT TACTATCTCA AGCCTGACTG GTCAAAGCTG 
GGGTCCCCTC AGGTGTGGAT AGATGCGGGG ACCCAGATTT TCTTTTCTTA CGCCATTGGC 
CTGGGGGCCC TCACAGCCCT GGGCAGCTAC AACCGCTTCA ACAACAACTG CTACAATGGG 
ACCAGCTTCT TTGCTGGCTT CGTGGTCTTC TCCATCCTGG GCTTCATGGC TGCAGAGCAG 
GGCGTGCACA TCTCCAAGGT GGCAGAGTCA GGGCCGGGCC TGGCCTTCAT CGCCTACCCG 
CGGGCTGTCA CGCTGATGCC AGTGGCCCCA CTCTGGGCTG CCCTGTTCTT CTTCATGCTG 
TTGCTGCTTG GTCTCGACAG CCAGTTTGTA GGTGTGGAGG GCTTCATCAC CGGCCTCCTC 
GACCTCCTCC CGGCCTCCTA CTACTTCCGT TTCCAAAGGG AGATCTCTGT GGCCCTCTGT 
TGTGCCCTCT GCTTTGTCAT CGATCTCTCC ATGGTGACTG ATGGCGGGAT GTACGTCTTC 
CAGCTGTTTG ACTACTACTC GGCCAGCGGC ACCACCCTGC TCTGGCAGGC CTTTTGGGAG 
TGCGTGGTGG TGGCCTGGGT GTACGGAGCT GACCGCTTCA TGGACGACAT TGCCTGTATG 
ATCGGGTACC GACCTTGCCC CTGGATGAAA TGGTGCTGGT CCTTCTTCAC CCCGCTGGTC 
TGCATGGGCA TCTTCATCTT CAACGTTGTG TACTACGAGC CGCTGGTCTA CAACAACACC 
TACGTGTACC CGTGGTGGGG TGAGGCCATG GGCTGGGCCT TCGCCCTGTC CTCCATGCTG 
TGCGTGCCGC TGCACCTCCT GGGCTGCCTC CTCAGGGCCA AGGGCACCAT GGCTGAGCGC 
TGGCAGCACC TGACCCAGCC CATCTGGGGC CTCCACCACT TGGAGTACCG AGCTCAGGAC 
GCAGATGTCA GGGGCCTGAC CACCCTGACC CCAGTGTCCG AGAGCAGCAA GGTCGTCGTG 
GTGGAGAGTG TCATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001136277.1
CDS	279..2156
Translation	MAKKSAENGIYSVSGDEKKGPLIAPGPDGAPAKGDGPVGLGTPGGRLAVPPRETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFMKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYNGTSFFAGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQPIWGLHHLEYRAQDADVRGLTTLTPVSESSKVVVVESVM

Target ORF information:

RefSeq Version	NM_001142805.1
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 6 member 8 (SLC6A8), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001142805.1

ORF Insert Sequence:

ATGGCGAAGA AGAGCGCCGA GAACGGCATC TATAGCGTGT CCGGCGACGA GAAGAAGGGC 
CCCCTCATCG CGCCCGGGCC CGACGGGGCC CCGGCCAAGG GCGACGGCCC CGTGGGCCTG 
GGGACACCCG GCGGCCGCCT GGCCGTGCCG CCGCGCGAGA CCTGGACGCG CCAGATGGAC 
TTCATCATGT CGTGCGTGGG CTTCGCCGTG GGCTTGGGCA ACGTGTGGCG CTTCCCCTAC 
CTGTGCTACA AGAACGGCGG AGGTGTGTTC CTTATTCCCT ACGTCCTGAT CGCCCTGGTT 
GGAGGAATCC CCATTTTCTT CTTAGAGATC TCGCTGGGCC AGTTCATGAA GGCCGGCAGC 
ATCAATGTCT GGAACATCTG TCCCCTGTTC AAAGGCCTGG GCTACGCCTC CATGGTGATC 
GTCTTCTACT GCAACACCTA CTACATCATG GTGCTGGCCT GGGGCTTCTA TTACCTGGTC 
AAGTCCTTTA CCACCACGCT GCCCTGGGCC ACATGTGGCC ACACCTGGAA CACTCCCGAC 
TGCGTGGAGA TCTTCCGCCA TGAAGACTGT GCCAATGCCA GCCTGGCCAA CCTCACCTGT 
GACCAGCTTG CTGACCGCCG GTCCCCTGTC ATCGAGTTCT GGGAGAACAA AGTCTTGAGG 
CTGTCTGGGG GACTGGAGGT GCCAGGGGCC CTCAACTGGG AGGTGACCCT TTGTCTGCTG 
GCCTGCTGGG TGCTGGTCTA CTTCTGTGTC TGGAAGGGGG TCAAATCCAC GGGAAAGATC 
GTGTACTTCA CTGCTACATT CCCCTACGTG GTCCTGGTCG TGCTGCTGGT GCGTGGAGTG 
CTGCTGCCTG GCGCCCTGGA TGGCATCATT TACTATCTCA AGCCTGACTG GTCAAAGCTG 
GGGTCCCCTC AGGTGTGGAT AGATGCGGGG ACCCAGATTT TCTTTTCTTA CGCCATTGGC 
CTGGGGGCCC TCACAGCCCT GGGCAGCTAC AACCGCTTCA ACAACAACTG CTACAATGGG 
ACCAGCTTCT TTGCTGGCTT CGTGGTCTTC TCCATCCTGG GCTTCATGGC TGCAGAGCAG 
GGCGTGCACA TCTCCAAGGT GGCAGAGTCA GGGCCGGGCC TGGCCTTCAT CGCCTACCCG 
CGGGCTGTCA CGCTGATGCC AGTGGCCCCA CTCTGGGCTG CCCTGTTCTT CTTCATGCTG 
TTGCTGCTTG GTCTCGACAG CCAGTTTGTA GGTGTGGAGG GCTTCATCAC CGGCCTCCTC 
GACCTCCTCC CGGCCTCCTA CTACTTCCGT TTCCAAAGGG AGATCTCTGT GGCCCTCTGT 
TGTGCCCTCT GCTTTGTCAT CGATCTCTCC ATGGTGACTG ATGGCGGGAT GTACGTCTTC 
CAGCTGTTTG ACTACTACTC GGCCAGCGGC ACCACCCTGC TCTGGCAGGC CTTTTGGGAG 
TGCGTGGTGG TGGCCTGGGT GTACGGAGCT GACCGCTTCA TGGACGACAT TGCCTGTATG 
ATCGGGTACC GACCTTGCCC CTGGATGAAA TGGTGCTGGT CCTTCTTCAC CCCGCTGGTC 
TGCATGGGCA TCTTCATCTT CAACGTTGTG TACTACGAGC CGCTGGTCTA CAACAACACC 
TACGTGTACC CGTGGTGGGG TGAGGCCATG GGCTGGGCCT TCGCCCTGTC CTCCATGCTG 
TGCGTGCCGC TGCACCTCCT GGGCTGCCTC CTCAGGGCCA AGGGCACCAT GGCTGAGCGC 
TGGCAGCACC TGACCCAGCC CATCTGGGGC CTCCACCACT TGGAGTACCG AGCTCAGGAC 
GCAGATGTCA GGGGCCTGAC CACCCTGACC CCAGTGTCCG AGAGCAGCAA GGTCGTCGTG 
GTGGAGAGTG TCATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLC6A8 ( NM_001142805.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001136277.1 Homo sapiens solute carrier family 6 member 8 (SLC6A8), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu27787
Clone ID Related Accession (Same CDS sequence)	NM_001142805.1 , NM_001142805.2
Accession Version	NM_001142805.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1878bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	sodium- and chloride-dependent creatine transporter 1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U52111.3, BC081558.1, L31409.1, AB209704.1, CX788315.1 and BE207407.1. On May 31, 2019 this sequence version replaced NM_001142805.1. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (2) lacks a 10-aa segment but has the same N- and C-termini, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB209704.1, SRR7346977.1213248.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGAAGA AGAGCGCCGA GAACGGCATC TATAGCGTGT CCGGCGACGA GAAGAAGGGC 
CCCCTCATCG CGCCCGGGCC CGACGGGGCC CCGGCCAAGG GCGACGGCCC CGTGGGCCTG 
GGGACACCCG GCGGCCGCCT GGCCGTGCCG CCGCGCGAGA CCTGGACGCG CCAGATGGAC 
TTCATCATGT CGTGCGTGGG CTTCGCCGTG GGCTTGGGCA ACGTGTGGCG CTTCCCCTAC 
CTGTGCTACA AGAACGGCGG AGGTGTGTTC CTTATTCCCT ACGTCCTGAT CGCCCTGGTT 
GGAGGAATCC CCATTTTCTT CTTAGAGATC TCGCTGGGCC AGTTCATGAA GGCCGGCAGC 
ATCAATGTCT GGAACATCTG TCCCCTGTTC AAAGGCCTGG GCTACGCCTC CATGGTGATC 
GTCTTCTACT GCAACACCTA CTACATCATG GTGCTGGCCT GGGGCTTCTA TTACCTGGTC 
AAGTCCTTTA CCACCACGCT GCCCTGGGCC ACATGTGGCC ACACCTGGAA CACTCCCGAC 
TGCGTGGAGA TCTTCCGCCA TGAAGACTGT GCCAATGCCA GCCTGGCCAA CCTCACCTGT 
GACCAGCTTG CTGACCGCCG GTCCCCTGTC ATCGAGTTCT GGGAGAACAA AGTCTTGAGG 
CTGTCTGGGG GACTGGAGGT GCCAGGGGCC CTCAACTGGG AGGTGACCCT TTGTCTGCTG 
GCCTGCTGGG TGCTGGTCTA CTTCTGTGTC TGGAAGGGGG TCAAATCCAC GGGAAAGATC 
GTGTACTTCA CTGCTACATT CCCCTACGTG GTCCTGGTCG TGCTGCTGGT GCGTGGAGTG 
CTGCTGCCTG GCGCCCTGGA TGGCATCATT TACTATCTCA AGCCTGACTG GTCAAAGCTG 
GGGTCCCCTC AGGTGTGGAT AGATGCGGGG ACCCAGATTT TCTTTTCTTA CGCCATTGGC 
CTGGGGGCCC TCACAGCCCT GGGCAGCTAC AACCGCTTCA ACAACAACTG CTACAATGGG 
ACCAGCTTCT TTGCTGGCTT CGTGGTCTTC TCCATCCTGG GCTTCATGGC TGCAGAGCAG 
GGCGTGCACA TCTCCAAGGT GGCAGAGTCA GGGCCGGGCC TGGCCTTCAT CGCCTACCCG 
CGGGCTGTCA CGCTGATGCC AGTGGCCCCA CTCTGGGCTG CCCTGTTCTT CTTCATGCTG 
TTGCTGCTTG GTCTCGACAG CCAGTTTGTA GGTGTGGAGG GCTTCATCAC CGGCCTCCTC 
GACCTCCTCC CGGCCTCCTA CTACTTCCGT TTCCAAAGGG AGATCTCTGT GGCCCTCTGT 
TGTGCCCTCT GCTTTGTCAT CGATCTCTCC ATGGTGACTG ATGGCGGGAT GTACGTCTTC 
CAGCTGTTTG ACTACTACTC GGCCAGCGGC ACCACCCTGC TCTGGCAGGC CTTTTGGGAG 
TGCGTGGTGG TGGCCTGGGT GTACGGAGCT GACCGCTTCA TGGACGACAT TGCCTGTATG 
ATCGGGTACC GACCTTGCCC CTGGATGAAA TGGTGCTGGT CCTTCTTCAC CCCGCTGGTC 
TGCATGGGCA TCTTCATCTT CAACGTTGTG TACTACGAGC CGCTGGTCTA CAACAACACC 
TACGTGTACC CGTGGTGGGG TGAGGCCATG GGCTGGGCCT TCGCCCTGTC CTCCATGCTG 
TGCGTGCCGC TGCACCTCCT GGGCTGCCTC CTCAGGGCCA AGGGCACCAT GGCTGAGCGC 
TGGCAGCACC TGACCCAGCC CATCTGGGGC CTCCACCACT TGGAGTACCG AGCTCAGGAC 
GCAGATGTCA GGGGCCTGAC CACCCTGACC CCAGTGTCCG AGAGCAGCAA GGTCGTCGTG 
GTGGAGAGTG TCATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001136277.1
CDS	650..2527
Translation	MAKKSAENGIYSVSGDEKKGPLIAPGPDGAPAKGDGPVGLGTPGGRLAVPPRETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFMKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYNGTSFFAGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQPIWGLHHLEYRAQDADVRGLTTLTPVSESSKVVVVESVM

Target ORF information:

RefSeq Version	NM_001142805.2
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 6 member 8 (SLC6A8), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001142805.2

ORF Insert Sequence:

ATGGCGAAGA AGAGCGCCGA GAACGGCATC TATAGCGTGT CCGGCGACGA GAAGAAGGGC 
CCCCTCATCG CGCCCGGGCC CGACGGGGCC CCGGCCAAGG GCGACGGCCC CGTGGGCCTG 
GGGACACCCG GCGGCCGCCT GGCCGTGCCG CCGCGCGAGA CCTGGACGCG CCAGATGGAC 
TTCATCATGT CGTGCGTGGG CTTCGCCGTG GGCTTGGGCA ACGTGTGGCG CTTCCCCTAC 
CTGTGCTACA AGAACGGCGG AGGTGTGTTC CTTATTCCCT ACGTCCTGAT CGCCCTGGTT 
GGAGGAATCC CCATTTTCTT CTTAGAGATC TCGCTGGGCC AGTTCATGAA GGCCGGCAGC 
ATCAATGTCT GGAACATCTG TCCCCTGTTC AAAGGCCTGG GCTACGCCTC CATGGTGATC 
GTCTTCTACT GCAACACCTA CTACATCATG GTGCTGGCCT GGGGCTTCTA TTACCTGGTC 
AAGTCCTTTA CCACCACGCT GCCCTGGGCC ACATGTGGCC ACACCTGGAA CACTCCCGAC 
TGCGTGGAGA TCTTCCGCCA TGAAGACTGT GCCAATGCCA GCCTGGCCAA CCTCACCTGT 
GACCAGCTTG CTGACCGCCG GTCCCCTGTC ATCGAGTTCT GGGAGAACAA AGTCTTGAGG 
CTGTCTGGGG GACTGGAGGT GCCAGGGGCC CTCAACTGGG AGGTGACCCT TTGTCTGCTG 
GCCTGCTGGG TGCTGGTCTA CTTCTGTGTC TGGAAGGGGG TCAAATCCAC GGGAAAGATC 
GTGTACTTCA CTGCTACATT CCCCTACGTG GTCCTGGTCG TGCTGCTGGT GCGTGGAGTG 
CTGCTGCCTG GCGCCCTGGA TGGCATCATT TACTATCTCA AGCCTGACTG GTCAAAGCTG 
GGGTCCCCTC AGGTGTGGAT AGATGCGGGG ACCCAGATTT TCTTTTCTTA CGCCATTGGC 
CTGGGGGCCC TCACAGCCCT GGGCAGCTAC AACCGCTTCA ACAACAACTG CTACAATGGG 
ACCAGCTTCT TTGCTGGCTT CGTGGTCTTC TCCATCCTGG GCTTCATGGC TGCAGAGCAG 
GGCGTGCACA TCTCCAAGGT GGCAGAGTCA GGGCCGGGCC TGGCCTTCAT CGCCTACCCG 
CGGGCTGTCA CGCTGATGCC AGTGGCCCCA CTCTGGGCTG CCCTGTTCTT CTTCATGCTG 
TTGCTGCTTG GTCTCGACAG CCAGTTTGTA GGTGTGGAGG GCTTCATCAC CGGCCTCCTC 
GACCTCCTCC CGGCCTCCTA CTACTTCCGT TTCCAAAGGG AGATCTCTGT GGCCCTCTGT 
TGTGCCCTCT GCTTTGTCAT CGATCTCTCC ATGGTGACTG ATGGCGGGAT GTACGTCTTC 
CAGCTGTTTG ACTACTACTC GGCCAGCGGC ACCACCCTGC TCTGGCAGGC CTTTTGGGAG 
TGCGTGGTGG TGGCCTGGGT GTACGGAGCT GACCGCTTCA TGGACGACAT TGCCTGTATG 
ATCGGGTACC GACCTTGCCC CTGGATGAAA TGGTGCTGGT CCTTCTTCAC CCCGCTGGTC 
TGCATGGGCA TCTTCATCTT CAACGTTGTG TACTACGAGC CGCTGGTCTA CAACAACACC 
TACGTGTACC CGTGGTGGGG TGAGGCCATG GGCTGGGCCT TCGCCCTGTC CTCCATGCTG 
TGCGTGCCGC TGCACCTCCT GGGCTGCCTC CTCAGGGCCA AGGGCACCAT GGCTGAGCGC 
TGGCAGCACC TGACCCAGCC CATCTGGGGC CTCCACCACT TGGAGTACCG AGCTCAGGAC 
GCAGATGTCA GGGGCCTGAC CACCCTGACC CCAGTGTCCG AGAGCAGCAA GGTCGTCGTG 
GTGGAGAGTG TCATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Laboratory diagnosis of creatine deficiency syndromes: a technical standard and guideline of the American College of Medical Genetics and Genomics.
Genetics in medicine : official journal of the American College of Medical Genetics19(2)256-263(2017 Feb)
Sharer JD,Bodamer O,Longo N,Tortorelli S,Wamelink MM,Young S

Abnormal N-Glycosylation of a Novel Missense Creatine Transporter Mutant, G561R, Associated with Cerebral Creatine Deficiency Syndromes Alters Transporter Activity and Localization.
Biological & pharmaceutical bulletin40(1)49-55(2017)
Uemura T,Ito S,Ohta Y,Tachikawa M,Wada T,Terasaki T,Ohtsuki S

Creatine biosynthesis and transport in health and disease.
Biochimie119146-65(2015 Dec)
Joncquel-Chevalier Curt M,Voicu PM,Fontaine M,Dessein AF,Porchet N,Mention-Mulliez K,Dobbelaere D,Soto-Ares G,Cheillan D,Vamecq J

Estimated carrier frequency of creatine transporter deficiency in females in the general population using functional characterization of novel missense variants in the SLC6A8 gene.
Gene565(2)187-91(2015 Jul)
DesRoches CL,Patel J,Wang P,Minassian B,Salomons GS,Marshall CR,Mercimek-Mahmutoglu S

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SLC6A8 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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