Gene Symbol | SLC6A4 |
Entrez Gene ID | 6532 |
Full Name | solute carrier family 6 member 4 |
Synonyms | 5-HTT,5-HTTLPR,5HTT,HTT,OCD1,SERT,SERT1,hSERT |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. [provided by RefSeq, Jul 2008]. |
Disorder MIM: | |
Disorder Html: | {Anxiety-related personality traits}, 607834 (3); {Obsessive-compulsive disorder}, 164230 (3) |