CASTOR1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CASTOR1
Entrez Gene ID	652968
Full Name	cytosolic arginine sensor for mTORC1 subunit 1
Synonyms	GATSL3
General protein information	Preferred Names cytosolic arginine sensor for mTORC1 subunit 1 Names cytosolic arginine sensor for mTORC1 subunit 1 GATS protein like 3 GATS-like protein 3 cellular arginine sensor for mTORC1 protein 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 22 Map Location: 22q12.2
Disorder MIM:	617034

mRNA and Protein(s)

mRNA	Protein	Name
NM_001037666.2	NP_001032755.1	cytosolic arginine sensor for mTORC1 subunit 1
NM_001037666.3	NP_001032755.1	cytosolic arginine sensor for mTORC1 subunit 1

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	GATSL3	XP_001234215.3
Pan troglodytes (chimpanzee)	GATSL3	XP_003317231.1
Mus musculus (house mouse)	Gatsl3	NP_082298.1
Rattus norvegicus (Norway rat)	Gatsl3	NP_001020299.1
Danio rerio (zebrafish)	gatsl3	NP_001018651.1
Homo sapiens (human)	GATSL3	NP_001032755.1
Canis lupus familiaris (dog)	GATSL3	XP_865775.1
Bos taurus (cattle)	GATSL3	NP_001074983.1
Xenopus tropicalis (tropical clawed frog)	gatsl3	NP_001096480.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Mechanism of arginine sensing by CASTOR1 upstream of mTORC1.
Saxton RA, Chantranupong L, Knockenhauer KE, Schwartz TU, Sabatini DM
Nature536(7615)229-33(2016 08)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

1.8 A crystal structure of arginine-bound CASTOR1
Title: Mechanism of arginine sensing by CASTOR1 upstream of mTORC1.

Study establishes the CASTOR1 homodimer and CASTOR1-CASTOR2 heterodimer as arginine sensors for the mTORC1 pathway.
Title: The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway.

This genome wide association study identified a new rheumatoid arthritis susceptibility locus mapping to 22q12 in the GATSL3 gene.
Title: Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study.

The following CASTOR1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CASTOR1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu15138	NM_001037666.3 Latest version!	Homo sapiens cytosolic arginine sensor for mTORC1 subunit 1 (CASTOR1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu15138	NM_001037666.2	Homo sapiens cytosolic arginine sensor for mTORC1 subunit 1 (CASTOR1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CASTOR1 ( NM_001037666.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001032755.1 Homo sapiens cytosolic arginine sensor for mTORC1 subunit 1 (CASTOR1), mRNA.

Price & Availability↑

CloneID	OHu15138
Clone ID Related Accession (Same CDS sequence)	NM_001037666.2 , NM_001037666.3
Accession Version	NM_001037666.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 990bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-10
Organism	Homo sapiens(human)
Product	cytosolic arginine sensor for mTORC1 subunit 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA343534.1, AC004997.2 and BC021927.1. On Jul 12, 2008 this sequence version replaced NM_001037666.1. ##Evidence-Data-START## Transcript exon combination :: BC021927.1, SRR1163658.455422.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGAGCTGC ACATCCTAGA ACACCGGGTG CGGGTGCTGA GCGTCGCCCG TCCCGGTCTC 
TGGCTCTACA CCCACCCGCT CATCAAGCTG CTCTTCCTGC CCCGCCGCAG CCGGTGCAAG 
TTCTTCAGCC TGACGGAGAC CCCTGAGGAT TACACGCTTA TGGTGGACGA GGAGGGCTTT 
AAAGAGCTGC CCCCATCTGA GTTCCTGCAA GTAGCTGAGG CCACATGGCT GGTGCTGAAC 
GTGTCGTCTC ACAGCGGTGC GGCAGTGCAG GCTGCTGGGG TCACCAAGAT CGCCCGTTCG 
GTCATCGCGC CACTGGCCGA GCACCACGTG TCTGTGCTGA TGCTGTCCAC TTACCAGACG 
GACTTCATCC TGGTGCGGGA GCAGGACCTG TCCGTGGTGA TCCACACGCT GGCCCAGGAG 
TTCGACATTT ACCGCGAGGT GGGCGGAGAG CCTGTGCCTG TGACGAGGGA TGATTCCAGC 
AATGGCTTTC CCCGCACTCA GCATGGGCCC AGCCCCACGG TGCATCCCAT CCAGAGCCCA 
CAGAACCGCT TCTGTGTCCT CACACTGGAC CCTGAGACGC TTCCAGCCAT CGCCACCACC 
CTCATAGATG TCCTCTTCTA CTCGCACAGC ACCCCCAAGG AGGCAGCCTC TAGCAGTCCT 
GAACCCAGCT CCATCACGTT CTTTGCCTTC TCCCTCATCG AGGGTTATAT CTCCATTGTC 
ATGGATGCTG AAACACAGAA AAAGTTCCCC AGTGACCTCC TGCTGACCAG CTCCTCGGGG 
GAGCTGTGGA GGATGGTGCG CATCGGTGGA CAGCCCCTGG GCTTTGATGA ATGTGGCATC 
GTGGCACAGA TTGCAGGTCC CCTGGCTGCC GCTGACATCT CTGCCTACTA CATCAGCACC 
TTCAACTTCG ACCACGCCCT GGTGCCCGAG GACGGTATCG GCAGCGTCAT CGAGGTCCTC 
CAGCGGCGGC AGGAAGGCCT GGCTTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001032755.1
CDS	131..1120
Translation	MELHILEHRVRVLSVARPGLWLYTHPLIKLLFLPRRSRCKFFSLTETPEDYTLMVDEEGFKELPPSEFLQVAEATWLVLNVSSHSGAAVQAAGVTKIARSVIAPLAEHHVSVLMLSTYQTDFILVREQDLSVVIHTLAQEFDIYREVGGEPVPVTRDDSSNGFPRTQHGPSPTVHPIQSPQNRFCVLTLDPETLPAIATTLIDVLFYSHSTPKEAASSSPEPSSITFFAFSLIEGYISIVMDAETQKKFPSDLLLTSSSGELWRMVRIGGQPLGFDECGIVAQIAGPLAAADISAYYISTFNFDHALVPEDGIGSVIEVLQRRQEGLAS

Target ORF information:

RefSeq Version	NM_001037666.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cytosolic arginine sensor for mTORC1 subunit 1 (CASTOR1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001037666.2

ORF Insert Sequence:

ATGGAGCTGC ACATCCTAGA ACACCGGGTG CGGGTGCTGA GCGTCGCCCG TCCCGGTCTC 
TGGCTCTACA CCCACCCGCT CATCAAGCTG CTCTTCCTGC CCCGCCGCAG CCGGTGCAAG 
TTCTTCAGCC TGACGGAGAC CCCTGAGGAT TACACGCTTA TGGTGGACGA GGAGGGCTTT 
AAAGAGCTGC CCCCATCTGA GTTCCTGCAA GTAGCTGAGG CCACATGGCT GGTGCTGAAC 
GTGTCGTCTC ACAGCGGTGC GGCAGTGCAG GCTGCTGGGG TCACCAAGAT CGCCCGTTCG 
GTCATCGCGC CACTGGCCGA GCACCACGTG TCTGTGCTGA TGCTGTCCAC TTACCAGACG 
GACTTCATCC TGGTGCGGGA GCAGGACCTG TCCGTGGTGA TCCACACGCT GGCCCAGGAG 
TTCGACATTT ACCGCGAGGT GGGCGGAGAG CCTGTGCCTG TGACGAGGGA TGATTCCAGC 
AATGGCTTTC CCCGCACTCA GCATGGGCCC AGCCCCACGG TGCATCCCAT CCAGAGCCCA 
CAGAACCGCT TCTGTGTCCT CACACTGGAC CCTGAGACGC TTCCAGCCAT CGCCACCACC 
CTCATAGATG TCCTCTTCTA CTCGCACAGC ACCCCCAAGG AGGCAGCCTC TAGCAGTCCT 
GAACCCAGCT CCATCACGTT CTTTGCCTTC TCCCTCATCG AGGGTTATAT CTCCATTGTC 
ATGGATGCTG AAACACAGAA AAAGTTCCCC AGTGACCTCC TGCTGACCAG CTCCTCGGGG 
GAGCTGTGGA GGATGGTGCG CATCGGTGGA CAGCCCCTGG GCTTTGATGA ATGTGGCATC 
GTGGCACAGA TTGCAGGTCC CCTGGCTGCC GCTGACATCT CTGCCTACTA CATCAGCACC 
TTCAACTTCG ACCACGCCCT GGTGCCCGAG GACGGTATCG GCAGCGTCAT CGAGGTCCTC 
CAGCGGCGGC AGGAAGGCCT GGCTTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CASTOR1 ( NM_001037666.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001032755.1 Homo sapiens cytosolic arginine sensor for mTORC1 subunit 1 (CASTOR1), mRNA.

Price & Availability↑

CloneID	OHu15138
Clone ID Related Accession (Same CDS sequence)	NM_001037666.2 , NM_001037666.3
Accession Version	NM_001037666.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 990bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Homo sapiens(human)
Product	cytosolic arginine sensor for mTORC1 subunit 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA343534.1, AC004997.2 and BC021927.1. On Nov 30, 2019 this sequence version replaced NM_001037666.2. ##Evidence-Data-START## Transcript exon combination :: AK055587.1, BC021927.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGAGCTGC ACATCCTAGA ACACCGGGTG CGGGTGCTGA GCGTCGCCCG TCCCGGTCTC 
TGGCTCTACA CCCACCCGCT CATCAAGCTG CTCTTCCTGC CCCGCCGCAG CCGGTGCAAG 
TTCTTCAGCC TGACGGAGAC CCCTGAGGAT TACACGCTTA TGGTGGACGA GGAGGGCTTT 
AAAGAGCTGC CCCCATCTGA GTTCCTGCAA GTAGCTGAGG CCACATGGCT GGTGCTGAAC 
GTGTCGTCTC ACAGCGGTGC GGCAGTGCAG GCTGCTGGGG TCACCAAGAT CGCCCGTTCG 
GTCATCGCGC CACTGGCCGA GCACCACGTG TCTGTGCTGA TGCTGTCCAC TTACCAGACG 
GACTTCATCC TGGTGCGGGA GCAGGACCTG TCCGTGGTGA TCCACACGCT GGCCCAGGAG 
TTCGACATTT ACCGCGAGGT GGGCGGAGAG CCTGTGCCTG TGACGAGGGA TGATTCCAGC 
AATGGCTTTC CCCGCACTCA GCATGGGCCC AGCCCCACGG TGCATCCCAT CCAGAGCCCA 
CAGAACCGCT TCTGTGTCCT CACACTGGAC CCTGAGACGC TTCCAGCCAT CGCCACCACC 
CTCATAGATG TCCTCTTCTA CTCGCACAGC ACCCCCAAGG AGGCAGCCTC TAGCAGTCCT 
GAACCCAGCT CCATCACGTT CTTTGCCTTC TCCCTCATCG AGGGTTATAT CTCCATTGTC 
ATGGATGCTG AAACACAGAA AAAGTTCCCC AGTGACCTCC TGCTGACCAG CTCCTCGGGG 
GAGCTGTGGA GGATGGTGCG CATCGGTGGA CAGCCCCTGG GCTTTGATGA ATGTGGCATC 
GTGGCACAGA TTGCAGGTCC CCTGGCTGCC GCTGACATCT CTGCCTACTA CATCAGCACC 
TTCAACTTCG ACCACGCCCT GGTGCCCGAG GACGGTATCG GCAGCGTCAT CGAGGTCCTC 
CAGCGGCGGC AGGAAGGCCT GGCTTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001032755.1
CDS	9..998
Translation	MELHILEHRVRVLSVARPGLWLYTHPLIKLLFLPRRSRCKFFSLTETPEDYTLMVDEEGFKELPPSEFLQVAEATWLVLNVSSHSGAAVQAAGVTKIARSVIAPLAEHHVSVLMLSTYQTDFILVREQDLSVVIHTLAQEFDIYREVGGEPVPVTRDDSSNGFPRTQHGPSPTVHPIQSPQNRFCVLTLDPETLPAIATTLIDVLFYSHSTPKEAASSSPEPSSITFFAFSLIEGYISIVMDAETQKKFPSDLLLTSSSGELWRMVRIGGQPLGFDECGIVAQIAGPLAAADISAYYISTFNFDHALVPEDGIGSVIEVLQRRQEGLAS

Target ORF information:

RefSeq Version	NM_001037666.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cytosolic arginine sensor for mTORC1 subunit 1 (CASTOR1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001037666.3

ORF Insert Sequence:

ATGGAGCTGC ACATCCTAGA ACACCGGGTG CGGGTGCTGA GCGTCGCCCG TCCCGGTCTC 
TGGCTCTACA CCCACCCGCT CATCAAGCTG CTCTTCCTGC CCCGCCGCAG CCGGTGCAAG 
TTCTTCAGCC TGACGGAGAC CCCTGAGGAT TACACGCTTA TGGTGGACGA GGAGGGCTTT 
AAAGAGCTGC CCCCATCTGA GTTCCTGCAA GTAGCTGAGG CCACATGGCT GGTGCTGAAC 
GTGTCGTCTC ACAGCGGTGC GGCAGTGCAG GCTGCTGGGG TCACCAAGAT CGCCCGTTCG 
GTCATCGCGC CACTGGCCGA GCACCACGTG TCTGTGCTGA TGCTGTCCAC TTACCAGACG 
GACTTCATCC TGGTGCGGGA GCAGGACCTG TCCGTGGTGA TCCACACGCT GGCCCAGGAG 
TTCGACATTT ACCGCGAGGT GGGCGGAGAG CCTGTGCCTG TGACGAGGGA TGATTCCAGC 
AATGGCTTTC CCCGCACTCA GCATGGGCCC AGCCCCACGG TGCATCCCAT CCAGAGCCCA 
CAGAACCGCT TCTGTGTCCT CACACTGGAC CCTGAGACGC TTCCAGCCAT CGCCACCACC 
CTCATAGATG TCCTCTTCTA CTCGCACAGC ACCCCCAAGG AGGCAGCCTC TAGCAGTCCT 
GAACCCAGCT CCATCACGTT CTTTGCCTTC TCCCTCATCG AGGGTTATAT CTCCATTGTC 
ATGGATGCTG AAACACAGAA AAAGTTCCCC AGTGACCTCC TGCTGACCAG CTCCTCGGGG 
GAGCTGTGGA GGATGGTGCG CATCGGTGGA CAGCCCCTGG GCTTTGATGA ATGTGGCATC 
GTGGCACAGA TTGCAGGTCC CCTGGCTGCC GCTGACATCT CTGCCTACTA CATCAGCACC 
TTCAACTTCG ACCACGCCCT GGTGCCCGAG GACGGTATCG GCAGCGTCAT CGAGGTCCTC 
CAGCGGCGGC AGGAAGGCCT GGCTTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Mechanism of arginine sensing by CASTOR1 upstream of mTORC1.
Nature536(7615)229-33(2016 08)
Saxton RA,Chantranupong L,Knockenhauer KE,Schwartz TU,Sabatini DM

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CASTOR1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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