MARCKSL1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MARCKSL1
Entrez Gene ID	65108
Full Name	MARCKS like 1
Synonyms	F52,MACMARCKS,MLP,MLP1,MRP
General protein information	Preferred Names MARCKS like 1 Names MARCKS-related protein MARCKS-like protein 1 mac-MARCKS macrophage myristoylated alanine-rich C kinase substrate
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p35.1
Summary	This gene encodes a member of the myristoylated alanine-rich C-kinase substrate (MARCKS) family. Members of this family play a role in cytoskeletal regulation, protein kinase C signaling and calmodulin signaling. The encoded protein affects the formation of adherens junction. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are located on the long arm of chromosomes 6 and 10. [provided by RefSeq, Jun 2012].
Disorder MIM:	602940

mRNA and Protein(s)

mRNA	Protein	Name
NM_023009.6	NP_075385.1	MARCKS-related protein
NM_023009.7	NP_075385.1	MARCKS-related protein

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Marcksl1	NP_034937.1
Canis lupus familiaris (dog)	MARCKSL1	XP_854637.1
Rattus norvegicus (Norway rat)	Marcksl1	NP_110489.1
Homo sapiens (human)	MARCKSL1	NP_075385.1
Rattus norvegicus (Norway rat)	LOC100911158	XP_003750086.1
Rattus norvegicus (Norway rat)	LOC100911122	XP_003750085.1
Pan troglodytes (chimpanzee)	MARCKSL1	XP_001151702.3
	MARCKSL1	XP_002802334.1
Bos taurus (cattle)	MARCKSL1	NP_001069640.1

Gene Ontology
Bibliography

Related articles in PubMed

MARCKSL1 exhibits anti-angiogenic effects through suppression of VEGFR-2-dependent Akt/PDK-1/mTOR phosphorylation.
Kim BR, Lee SH, Park MS, Seo SH, Park YM, Kwon YJ, Rho SB
Oncology reports35(2)1041-8(2016 Feb)

Lysyl oxidase-like 2 (LOXL2) controls tumor-associated cell proliferation through the interaction with MARCKSL1.
Kim BR, Dong SM, Seo SH, Lee JH, Lee JM, Lee SH, Rho SB
Cellular signalling26(9)1765-73(2014 Sep)

The prognostic value of MARCKS-like 1 in lymph node-negative breast cancer.
Jonsdottir K, Zhang H, Jhagroe D, Skaland I, Slewa A, Bj?rkblom B, Coffey ET, Gudlaugsson E, Smaaland R, Janssen EA, Baak JP
Breast cancer research and treatment135(2)381-90(2012 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

MARCKSL1 showed potent anti-angiogenic activity and reduced the levels of VEGF and HIF-1alpha expression. MARCKSL1 decreased VEGFinduced phosphorylation of the PI3K/Akt signaling pathway components.
Title: MARCKSL1 exhibits anti-angiogenic effects through suppression of VEGFR-2-dependent Akt/PDK-1/mTOR phosphorylation.

MARCKSL1 suppresses LOXL2-induced oncogenesis.
Title: Lysyl oxidase-like 2 (LOXL2) controls tumor-associated cell proliferation through the interaction with MARCKSL1.

Patients with high expression of PPH3 and high MARCKSL1 protein had a lower survival rate versus patients with low MARCKSL1 and high PPH3 expression.
Title: The prognostic value of MARCKS-like 1 in lymph node-negative breast cancer.

Gene knockdown in prostate cancer cells or in neurons reveals a critical role for MARCKSL1 in migration that is dependent on the phosphorylation state.
Title: c-Jun N-terminal kinase phosphorylation of MARCKSL1 determines actin stability and migration in neurons and in cancer cells.

The following MARCKSL1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MARCKSL1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu11809	NM_023009.7 Latest version!	Homo sapiens MARCKS like 1 (MARCKSL1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu11809	NM_023009.6	Homo sapiens MARCKS like 1 (MARCKSL1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MARCKSL1 ( NM_023009.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_075385.1 Homo sapiens MARCKS like 1 (MARCKSL1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu11809
Clone ID Related Accession (Same CDS sequence)	NM_023009.6 , NM_023009.7
Accession Version	NM_023009.6	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 588bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	MARCKS-related protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL109945.15, AI879076.1, BC007904.2 and N70661.1. On Jun 26, 2012 this sequence version replaced NM_023009.5. Transcript Variant: This variant (1) represents the longer transcript and is protein coding. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC066915.1, AY007131.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCAGCC AGAGCTCCAA GGCTCCCCGG GGCGACGTGA CCGCCGAGGA GGCAGCAGGC 
GCTTCCCCCG CGAAGGCCAA CGGCCAGGAG AATGGCCACG TGAAAAGCAA TGGAGACTTA 
TCCCCCAAGG GTGAAGGGGA GTCGCCCCCT GTGAACGGAA CAGATGAGGC AGCCGGGGCC 
ACTGGCGATG CCATCGAGCC AGCACCCCCT AGCCAGGGTG CTGAGGCCAA GGGGGAGGTC 
CCCCCCAAGG AGACCCCCAA GAAGAAGAAG AAATTCTCTT TCAAGAAGCC TTTCAAATTG 
AGCGGCCTGT CCTTCAAGAG AAATCGGAAG GAGGGTGGGG GTGATTCTTC TGCCTCCTCA 
CCCACAGAGG AAGAGCAGGA GCAGGGGGAG ATCGGTGCCT GCAGCGACGA GGGCACTGCT 
CAGGAAGGGA AGGCCGCAGC CACCCCTGAG AGCCAGGAAC CCCAGGCCAA GGGGGCAGAG 
GCTAGTGCAG CCTCAGAAGA AGAGGCAGGG CCCCAGGCTA CAGAGCCATC CACTCCCTCG 
GGGCCGGAGA GTGGCCCTAC ACCAGCCAGC GCTGAGCAGA ATGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_075385.1
CDS	207..794
Translation	MGSQSSKAPRGDVTAEEAAGASPAKANGQENGHVKSNGDLSPKGEGESPPVNGTDEAAGATGDAIEPAPPSQGAEAKGEVPPKETPKKKKKFSFKKPFKLSGLSFKRNRKEGGGDSSASSPTEEEQEQGEIGACSDEGTAQEGKAAATPESQEPQAKGAEASAASEEEAGPQATEPSTPSGPESGPTPASAEQNE

Target ORF information:

RefSeq Version	NM_023009.6
Organism	Homo sapiens(human)
Definition	Homo sapiens MARCKS like 1 (MARCKSL1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_023009.6

ORF Insert Sequence:

ATGGGCAGCC AGAGCTCCAA GGCTCCCCGG GGCGACGTGA CCGCCGAGGA GGCAGCAGGC 
GCTTCCCCCG CGAAGGCCAA CGGCCAGGAG AATGGCCACG TGAAAAGCAA TGGAGACTTA 
TCCCCCAAGG GTGAAGGGGA GTCGCCCCCT GTGAACGGAA CAGATGAGGC AGCCGGGGCC 
ACTGGCGATG CCATCGAGCC AGCACCCCCT AGCCAGGGTG CTGAGGCCAA GGGGGAGGTC 
CCCCCCAAGG AGACCCCCAA GAAGAAGAAG AAATTCTCTT TCAAGAAGCC TTTCAAATTG 
AGCGGCCTGT CCTTCAAGAG AAATCGGAAG GAGGGTGGGG GTGATTCTTC TGCCTCCTCA 
CCCACAGAGG AAGAGCAGGA GCAGGGGGAG ATCGGTGCCT GCAGCGACGA GGGCACTGCT 
CAGGAAGGGA AGGCCGCAGC CACCCCTGAG AGCCAGGAAC CCCAGGCCAA GGGGGCAGAG 
GCTAGTGCAG CCTCAGAAGA AGAGGCAGGG CCCCAGGCTA CAGAGCCATC CACTCCCTCG 
GGGCCGGAGA GTGGCCCTAC ACCAGCCAGC GCTGAGCAGA ATGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MARCKSL1 ( NM_023009.7 ) cDNA ORF clone, Homo sapiens(human) -> NP_075385.1 Homo sapiens MARCKS like 1 (MARCKSL1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu11809
Clone ID Related Accession (Same CDS sequence)	NM_023009.6 , NM_023009.7
Accession Version	NM_023009.7 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 588bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	MARCKS-related protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AI879076.1, BC007904.2 and N70661.1. On Nov 22, 2018 this sequence version replaced NM_023009.6. Transcript Variant: This variant (1) represents the longer transcript and is protein coding. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC066915.1, SRR3476690.130069.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000329421.8/ ENSP00000362638.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGCAGCC AGAGCTCCAA GGCTCCCCGG GGCGACGTGA CCGCCGAGGA GGCAGCAGGC 
GCTTCCCCCG CGAAGGCCAA CGGCCAGGAG AATGGCCACG TGAAAAGCAA TGGAGACTTA 
TCCCCCAAGG GTGAAGGGGA GTCGCCCCCT GTGAACGGAA CAGATGAGGC AGCCGGGGCC 
ACTGGCGATG CCATCGAGCC AGCACCCCCT AGCCAGGGTG CTGAGGCCAA GGGGGAGGTC 
CCCCCCAAGG AGACCCCCAA GAAGAAGAAG AAATTCTCTT TCAAGAAGCC TTTCAAATTG 
AGCGGCCTGT CCTTCAAGAG AAATCGGAAG GAGGGTGGGG GTGATTCTTC TGCCTCCTCA 
CCCACAGAGG AAGAGCAGGA GCAGGGGGAG ATCGGTGCCT GCAGCGACGA GGGCACTGCT 
CAGGAAGGGA AGGCCGCAGC CACCCCTGAG AGCCAGGAAC CCCAGGCCAA GGGGGCAGAG 
GCTAGTGCAG CCTCAGAAGA AGAGGCAGGG CCCCAGGCTA CAGAGCCATC CACTCCCTCG 
GGGCCGGAGA GTGGCCCTAC ACCAGCCAGC GCTGAGCAGA ATGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_075385.1
CDS	201..788
Translation	MGSQSSKAPRGDVTAEEAAGASPAKANGQENGHVKSNGDLSPKGEGESPPVNGTDEAAGATGDAIEPAPPSQGAEAKGEVPPKETPKKKKKFSFKKPFKLSGLSFKRNRKEGGGDSSASSPTEEEQEQGEIGACSDEGTAQEGKAAATPESQEPQAKGAEASAASEEEAGPQATEPSTPSGPESGPTPASAEQNE

Target ORF information:

RefSeq Version	NM_023009.7
Organism	Homo sapiens(human)
Definition	Homo sapiens MARCKS like 1 (MARCKSL1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_023009.7

ORF Insert Sequence:

ATGGGCAGCC AGAGCTCCAA GGCTCCCCGG GGCGACGTGA CCGCCGAGGA GGCAGCAGGC 
GCTTCCCCCG CGAAGGCCAA CGGCCAGGAG AATGGCCACG TGAAAAGCAA TGGAGACTTA 
TCCCCCAAGG GTGAAGGGGA GTCGCCCCCT GTGAACGGAA CAGATGAGGC AGCCGGGGCC 
ACTGGCGATG CCATCGAGCC AGCACCCCCT AGCCAGGGTG CTGAGGCCAA GGGGGAGGTC 
CCCCCCAAGG AGACCCCCAA GAAGAAGAAG AAATTCTCTT TCAAGAAGCC TTTCAAATTG 
AGCGGCCTGT CCTTCAAGAG AAATCGGAAG GAGGGTGGGG GTGATTCTTC TGCCTCCTCA 
CCCACAGAGG AAGAGCAGGA GCAGGGGGAG ATCGGTGCCT GCAGCGACGA GGGCACTGCT 
CAGGAAGGGA AGGCCGCAGC CACCCCTGAG AGCCAGGAAC CCCAGGCCAA GGGGGCAGAG 
GCTAGTGCAG CCTCAGAAGA AGAGGCAGGG CCCCAGGCTA CAGAGCCATC CACTCCCTCG 
GGGCCGGAGA GTGGCCCTAC ACCAGCCAGC GCTGAGCAGA ATGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MARCKSL1 exhibits anti-angiogenic effects through suppression of VEGFR-2-dependent Akt/PDK-1/mTOR phosphorylation.
Oncology reports35(2)1041-8(2016 Feb)
Kim BR,Lee SH,Park MS,Seo SH,Park YM,Kwon YJ,Rho SB

Lysyl oxidase-like 2 (LOXL2) controls tumor-associated cell proliferation through the interaction with MARCKSL1.
Cellular signalling26(9)1765-73(2014 Sep)
Kim BR,Dong SM,Seo SH,Lee JH,Lee JM,Lee SH,Rho SB

The prognostic value of MARCKS-like 1 in lymph node-negative breast cancer.
Breast cancer research and treatment135(2)381-90(2012 Sep)
Jonsdottir K,Zhang H,Jhagroe D,Skaland I,Slewa A,Bj?rkblom B,Coffey ET,Gudlaugsson E,Smaaland R,Janssen EA,Baak JP

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MARCKSL1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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