PINK1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PINK1
Entrez Gene ID	65018
Full Name	PTEN induced putative kinase 1
Synonyms	BRPK,PARK6
General protein information	Preferred Names PTEN induced putative kinase 1 Names serine/threonine-protein kinase PINK1, mitochondrial PTEN-induced putative kinase protein 1 protein kinase BRPK
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p36.12
Summary	This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 2008].
Disorder MIM:	608309
Disorder Html:	Parkinson disease 6, early onset, 605909 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_032409.3	NP_115785.1	serine/threonine-protein kinase PINK1, mitochondrial precursor
NM_032409.2	NP_115785.1	serine/threonine-protein kinase PINK1, mitochondrial precursor

Pathways from BioSystems

Homologies

	LOC698013	XP_001086306.1
Canis lupus familiaris (dog)	PINK1	XP_005617989.1
Homo sapiens (human)	PINK1	NP_115785.1
	PINK1	XP_001096957.1
Mus musculus (house mouse)	Pink1	NP_081156.2
Caenorhabditis elegans (roundworm)	pink-1	NP_495017.1
Bos taurus (cattle)	PINK1	NP_001093171.1
Rattus norvegicus (Norway rat)	Pink1	NP_001100164.1
Danio rerio (zebrafish)	pink1	NP_001008628.1
Pan troglodytes (chimpanzee)	PINK1	XP_001164912.2
Gallus gallus (chicken)	PINK1	XP_423139.3

Gene Ontology
Bibliography

Related articles in PubMed

An invisible ubiquitin conformation is required for efficient phosphorylation by PINK1.
Gladkova C, Schubert AF, Wagstaff JL, Pruneda JN, Freund SM, Komander D
The EMBO journal36(24)3555-3572(2017 12)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PINK1 utilises a lowly populated yet more suitable C-terminally retracted (Ub-CR) conformation of Ub for efficient phosphorylation.
Title: An invisible ubiquitin conformation is required for efficient phosphorylation by PINK1.

PINK1 was downregulated in the brains of patients with Alzheimer's disease.
Title: PINK1 signalling rescues amyloid pathology and mitochondrial dysfunction in Alzheimer's disease.

PINK1 mutation is associated with Alzheimer disease.
Title: Analysis of neurodegenerative Mendelian genes in clinically diagnosed Alzheimer Disease.

Adipogenic process can be dissected into 3 stages according to the participation of PARL-PINK1-Parkin system. Findings reveal the sequential adipogenic events directed by PARL-PINK1-Parkin system, add more evidence supporting the convergence of pathogenesis leading to neurodegenerative and metabolic disease
Title: Role of PARL-PINK1-Parkin pathway in adipocyte differentiation.

PINK1 silencing impaired BECN1 enrichment at mitochondria-associated membranes independently of PARK2, suggesting a novel role for PINK1 in regulating mitophagy.
Title: PINK1 and BECN1 relocalize at mitochondria-associated membranes during mitophagy and promote ER-mitochondria tethering and autophagosome formation.

The following PINK1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PINK1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu25380	NM_032409.3 Latest version!	Homo sapiens PTEN induced kinase 1 (PINK1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
View Old Accession Versions >>
OHu25380	NM_032409.2	Homo sapiens PTEN induced putative kinase 1 (PINK1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PINK1 ( NM_032409.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_115785.1 Homo sapiens PTEN induced kinase 1 (PINK1), mRNA.

Price & Availability↑

CloneID	OHu25380
Clone ID Related Accession (Same CDS sequence)	NM_032409.3 , NM_032409.2
Accession Version	NM_032409.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1746bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	serine/threonine-protein kinase PINK1, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB053323.1 and AL391357.20. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_032409.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB053323.1, SRR1660809.117321.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000321556.5/ ENSP00000364204.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGTGC GACAGGCGCT GGGCCGCGGC CTGCAGCTGG GTCGAGCGCT GCTGCTGCGC 
TTCACGGGCA AGCCCGGCCG GGCCTACGGC TTGGGGCGGC CGGGCCCGGC GGCGGGCTGT 
GTCCGCGGGG AGCGTCCAGG CTGGGCCGCA GGACCGGGCG CGGAGCCTCG CAGGGTCGGG 
CTCGGGCTCC CTAACCGTCT CCGCTTCTTC CGCCAGTCGG TGGCCGGGCT GGCGGCGCGG 
TTGCAGCGGC AGTTCGTGGT GCGGGCCTGG GGCTGCGCGG GCCCTTGCGG CCGGGCAGTC 
TTTCTGGCCT TCGGGCTAGG GCTGGGCCTC ATCGAGGAAA AACAGGCGGA GAGCCGGCGG 
GCGGTCTCGG CCTGTCAGGA GATCCAGGCA ATTTTTACCC AGAAAAGCAA GCCGGGGCCT 
GACCCGTTGG ACACGAGACG CTTGCAGGGC TTTCGGCTGG AGGAGTATCT GATAGGGCAG 
TCCATTGGTA AGGGCTGCAG TGCTGCTGTG TATGAAGCCA CCATGCCTAC ATTGCCCCAG 
AACCTGGAGG TGACAAAGAG CACCGGGTTG CTTCCAGGGA GAGGCCCAGG TACCAGTGCA 
CCAGGAGAAG GGCAGGAGCG AGCTCCGGGG GCCCCTGCCT TCCCCTTGGC CATCAAGATG 
ATGTGGAACA TCTCGGCAGG TTCCTCCAGC GAAGCCATCT TGAACACAAT GAGCCAGGAG 
CTGGTCCCAG CGAGCCGAGT GGCCTTGGCT GGGGAGTATG GAGCAGTCAC TTACAGAAAA 
TCCAAGAGAG GTCCCAAGCA ACTAGCCCCT CACCCCAACA TCATCCGGGT TCTCCGCGCC 
TTCACCTCTT CCGTGCCGCT GCTGCCAGGG GCCCTGGTCG ACTACCCTGA TGTGCTGCCC 
TCACGCCTCC ACCCTGAAGG CCTGGGCCAT GGCCGGACGC TGTTCCTCGT TATGAAGAAC 
TATCCCTGTA CCCTGCGCCA GTACCTTTGT GTGAACACAC CCAGCCCCCG CCTCGCCGCC 
ATGATGCTGC TGCAGCTGCT GGAAGGCGTG GACCATCTGG TTCAACAGGG CATCGCGCAC 
AGAGACCTGA AATCCGACAA CATCCTTGTG GAGCTGGACC CAGACGGCTG CCCCTGGCTG 
GTGATCGCAG ATTTTGGCTG CTGCCTGGCT GATGAGAGCA TCGGCCTGCA GTTGCCCTTC 
AGCAGCTGGT ACGTGGATCG GGGCGGAAAC GGCTGTCTGA TGGCCCCAGA GGTGTCCACG 
GCCCGTCCTG GCCCCAGGGC AGTGATTGAC TACAGCAAGG CTGATGCCTG GGCAGTGGGA 
GCCATCGCCT ATGAAATCTT CGGGCTTGTC AATCCCTTCT ACGGCCAGGG CAAGGCCCAC 
CTTGAAAGCC GCAGCTACCA AGAGGCTCAG CTACCTGCAC TGCCCGAGTC AGTGCCTCCA 
GACGTGAGAC AGTTGGTGAG GGCACTGCTC CAGCGAGAGG CCAGCAAGAG ACCATCTGCC 
CGAGTAGCCG CAAATGTGCT TCATCTAAGC CTCTGGGGTG AACATATTCT AGCCCTGAAG 
AATCTGAAGT TAGACAAGAT GGTTGGCTGG CTCCTCCAAC AATCGGCCGC CACTTTGTTG 
GCCAACAGGC TCACAGAGAA GTGTTGTGTG GAAACAAAAA TGAAGATGCT CTTTCTGGCT 
AACCTGGAGT GTGAAACGCT CTGCCAGGCA GCCCTCCTCC TCTGCTCATG GAGGGCAGCC 
CTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115785.1
CDS	92..1837
Translation	MAVRQALGRGLQLGRALLLRFTGKPGRAYGLGRPGPAAGCVRGERPGWAAGPGAEPRRVGLGLPNRLRFFRQSVAGLAARLQRQFVVRAWGCAGPCGRAVFLAFGLGLGLIEEKQAESRRAVSACQEIQAIFTQKSKPGPDPLDTRRLQGFRLEEYLIGQSIGKGCSAAVYEATMPTLPQNLEVTKSTGLLPGRGPGTSAPGEGQERAPGAPAFPLAIKMMWNISAGSSSEAILNTMSQELVPASRVALAGEYGAVTYRKSKRGPKQLAPHPNIIRVLRAFTSSVPLLPGALVDYPDVLPSRLHPEGLGHGRTLFLVMKNYPCTLRQYLCVNTPSPRLAAMMLLQLLEGVDHLVQQGIAHRDLKSDNILVELDPDGCPWLVIADFGCCLADESIGLQLPFSSWYVDRGGNGCLMAPEVSTARPGPRAVIDYSKADAWAVGAIAYEIFGLVNPFYGQGKAHLESRSYQEAQLPALPESVPPDVRQLVRALLQREASKRPSARVAANVLHLSLWGEHILALKNLKLDKMVGWLLQQSAATLLANRLTEKCCVETKMKMLFLANLECETLCQAALLLCSWRAAL

Target ORF information:

RefSeq Version	NM_032409.3
Organism	Homo sapiens(human)
Definition	Homo sapiens PTEN induced kinase 1 (PINK1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032409.3

ORF Insert Sequence:

ATGGCGGTGC GACAGGCGCT GGGCCGCGGC CTGCAGCTGG GTCGAGCGCT GCTGCTGCGC 
TTCACGGGCA AGCCCGGCCG GGCCTACGGC TTGGGGCGGC CGGGCCCGGC GGCGGGCTGT 
GTCCGCGGGG AGCGTCCAGG CTGGGCCGCA GGACCGGGCG CGGAGCCTCG CAGGGTCGGG 
CTCGGGCTCC CTAACCGTCT CCGCTTCTTC CGCCAGTCGG TGGCCGGGCT GGCGGCGCGG 
TTGCAGCGGC AGTTCGTGGT GCGGGCCTGG GGCTGCGCGG GCCCTTGCGG CCGGGCAGTC 
TTTCTGGCCT TCGGGCTAGG GCTGGGCCTC ATCGAGGAAA AACAGGCGGA GAGCCGGCGG 
GCGGTCTCGG CCTGTCAGGA GATCCAGGCA ATTTTTACCC AGAAAAGCAA GCCGGGGCCT 
GACCCGTTGG ACACGAGACG CTTGCAGGGC TTTCGGCTGG AGGAGTATCT GATAGGGCAG 
TCCATTGGTA AGGGCTGCAG TGCTGCTGTG TATGAAGCCA CCATGCCTAC ATTGCCCCAG 
AACCTGGAGG TGACAAAGAG CACCGGGTTG CTTCCAGGGA GAGGCCCAGG TACCAGTGCA 
CCAGGAGAAG GGCAGGAGCG AGCTCCGGGG GCCCCTGCCT TCCCCTTGGC CATCAAGATG 
ATGTGGAACA TCTCGGCAGG TTCCTCCAGC GAAGCCATCT TGAACACAAT GAGCCAGGAG 
CTGGTCCCAG CGAGCCGAGT GGCCTTGGCT GGGGAGTATG GAGCAGTCAC TTACAGAAAA 
TCCAAGAGAG GTCCCAAGCA ACTAGCCCCT CACCCCAACA TCATCCGGGT TCTCCGCGCC 
TTCACCTCTT CCGTGCCGCT GCTGCCAGGG GCCCTGGTCG ACTACCCTGA TGTGCTGCCC 
TCACGCCTCC ACCCTGAAGG CCTGGGCCAT GGCCGGACGC TGTTCCTCGT TATGAAGAAC 
TATCCCTGTA CCCTGCGCCA GTACCTTTGT GTGAACACAC CCAGCCCCCG CCTCGCCGCC 
ATGATGCTGC TGCAGCTGCT GGAAGGCGTG GACCATCTGG TTCAACAGGG CATCGCGCAC 
AGAGACCTGA AATCCGACAA CATCCTTGTG GAGCTGGACC CAGACGGCTG CCCCTGGCTG 
GTGATCGCAG ATTTTGGCTG CTGCCTGGCT GATGAGAGCA TCGGCCTGCA GTTGCCCTTC 
AGCAGCTGGT ACGTGGATCG GGGCGGAAAC GGCTGTCTGA TGGCCCCAGA GGTGTCCACG 
GCCCGTCCTG GCCCCAGGGC AGTGATTGAC TACAGCAAGG CTGATGCCTG GGCAGTGGGA 
GCCATCGCCT ATGAAATCTT CGGGCTTGTC AATCCCTTCT ACGGCCAGGG CAAGGCCCAC 
CTTGAAAGCC GCAGCTACCA AGAGGCTCAG CTACCTGCAC TGCCCGAGTC AGTGCCTCCA 
GACGTGAGAC AGTTGGTGAG GGCACTGCTC CAGCGAGAGG CCAGCAAGAG ACCATCTGCC 
CGAGTAGCCG CAAATGTGCT TCATCTAAGC CTCTGGGGTG AACATATTCT AGCCCTGAAG 
AATCTGAAGT TAGACAAGAT GGTTGGCTGG CTCCTCCAAC AATCGGCCGC CACTTTGTTG 
GCCAACAGGC TCACAGAGAA GTGTTGTGTG GAAACAAAAA TGAAGATGCT CTTTCTGGCT 
AACCTGGAGT GTGAAACGCT CTGCCAGGCA GCCCTCCTCC TCTGCTCATG GAGGGCAGCC 
CTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PINK1 ( NM_032409.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_115785.1 Homo sapiens PTEN induced putative kinase 1 (PINK1), mRNA.

Price & Availability↑

CloneID	OHu25380
Clone ID Related Accession (Same CDS sequence)	NM_032409.3 , NM_032409.2
Accession Version	NM_032409.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1746bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-31
Organism	Homo sapiens(human)
Product	serine/threonine-protein kinase PINK1, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB053323.1 and AL391357.20. This sequence is a reference standard in the RefSeqGene project. On Aug 16, 2006 this sequence version replaced NM_032409.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB053323.1, SRR1660809.117321.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGGTGC GACAGGCGCT GGGCCGCGGC CTGCAGCTGG GTCGAGCGCT GCTGCTGCGC 
TTCACGGGCA AGCCCGGCCG GGCCTACGGC TTGGGGCGGC CGGGCCCGGC GGCGGGCTGT 
GTCCGCGGGG AGCGTCCAGG CTGGGCCGCA GGACCGGGCG CGGAGCCTCG CAGGGTCGGG 
CTCGGGCTCC CTAACCGTCT CCGCTTCTTC CGCCAGTCGG TGGCCGGGCT GGCGGCGCGG 
TTGCAGCGGC AGTTCGTGGT GCGGGCCTGG GGCTGCGCGG GCCCTTGCGG CCGGGCAGTC 
TTTCTGGCCT TCGGGCTAGG GCTGGGCCTC ATCGAGGAAA AACAGGCGGA GAGCCGGCGG 
GCGGTCTCGG CCTGTCAGGA GATCCAGGCA ATTTTTACCC AGAAAAGCAA GCCGGGGCCT 
GACCCGTTGG ACACGAGACG CTTGCAGGGC TTTCGGCTGG AGGAGTATCT GATAGGGCAG 
TCCATTGGTA AGGGCTGCAG TGCTGCTGTG TATGAAGCCA CCATGCCTAC ATTGCCCCAG 
AACCTGGAGG TGACAAAGAG CACCGGGTTG CTTCCAGGGA GAGGCCCAGG TACCAGTGCA 
CCAGGAGAAG GGCAGGAGCG AGCTCCGGGG GCCCCTGCCT TCCCCTTGGC CATCAAGATG 
ATGTGGAACA TCTCGGCAGG TTCCTCCAGC GAAGCCATCT TGAACACAAT GAGCCAGGAG 
CTGGTCCCAG CGAGCCGAGT GGCCTTGGCT GGGGAGTATG GAGCAGTCAC TTACAGAAAA 
TCCAAGAGAG GTCCCAAGCA ACTAGCCCCT CACCCCAACA TCATCCGGGT TCTCCGCGCC 
TTCACCTCTT CCGTGCCGCT GCTGCCAGGG GCCCTGGTCG ACTACCCTGA TGTGCTGCCC 
TCACGCCTCC ACCCTGAAGG CCTGGGCCAT GGCCGGACGC TGTTCCTCGT TATGAAGAAC 
TATCCCTGTA CCCTGCGCCA GTACCTTTGT GTGAACACAC CCAGCCCCCG CCTCGCCGCC 
ATGATGCTGC TGCAGCTGCT GGAAGGCGTG GACCATCTGG TTCAACAGGG CATCGCGCAC 
AGAGACCTGA AATCCGACAA CATCCTTGTG GAGCTGGACC CAGACGGCTG CCCCTGGCTG 
GTGATCGCAG ATTTTGGCTG CTGCCTGGCT GATGAGAGCA TCGGCCTGCA GTTGCCCTTC 
AGCAGCTGGT ACGTGGATCG GGGCGGAAAC GGCTGTCTGA TGGCCCCAGA GGTGTCCACG 
GCCCGTCCTG GCCCCAGGGC AGTGATTGAC TACAGCAAGG CTGATGCCTG GGCAGTGGGA 
GCCATCGCCT ATGAAATCTT CGGGCTTGTC AATCCCTTCT ACGGCCAGGG CAAGGCCCAC 
CTTGAAAGCC GCAGCTACCA AGAGGCTCAG CTACCTGCAC TGCCCGAGTC AGTGCCTCCA 
GACGTGAGAC AGTTGGTGAG GGCACTGCTC CAGCGAGAGG CCAGCAAGAG ACCATCTGCC 
CGAGTAGCCG CAAATGTGCT TCATCTAAGC CTCTGGGGTG AACATATTCT AGCCCTGAAG 
AATCTGAAGT TAGACAAGAT GGTTGGCTGG CTCCTCCAAC AATCGGCCGC CACTTTGTTG 
GCCAACAGGC TCACAGAGAA GTGTTGTGTG GAAACAAAAA TGAAGATGCT CTTTCTGGCT 
AACCTGGAGT GTGAAACGCT CTGCCAGGCA GCCCTCCTCC TCTGCTCATG GAGGGCAGCC 
CTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115785.1
CDS	95..1840
Translation	MAVRQALGRGLQLGRALLLRFTGKPGRAYGLGRPGPAAGCVRGERPGWAAGPGAEPRRVGLGLPNRLRFFRQSVAGLAARLQRQFVVRAWGCAGPCGRAVFLAFGLGLGLIEEKQAESRRAVSACQEIQAIFTQKSKPGPDPLDTRRLQGFRLEEYLIGQSIGKGCSAAVYEATMPTLPQNLEVTKSTGLLPGRGPGTSAPGEGQERAPGAPAFPLAIKMMWNISAGSSSEAILNTMSQELVPASRVALAGEYGAVTYRKSKRGPKQLAPHPNIIRVLRAFTSSVPLLPGALVDYPDVLPSRLHPEGLGHGRTLFLVMKNYPCTLRQYLCVNTPSPRLAAMMLLQLLEGVDHLVQQGIAHRDLKSDNILVELDPDGCPWLVIADFGCCLADESIGLQLPFSSWYVDRGGNGCLMAPEVSTARPGPRAVIDYSKADAWAVGAIAYEIFGLVNPFYGQGKAHLESRSYQEAQLPALPESVPPDVRQLVRALLQREASKRPSARVAANVLHLSLWGEHILALKNLKLDKMVGWLLQQSAATLLANRLTEKCCVETKMKMLFLANLECETLCQAALLLCSWRAAL

Target ORF information:

RefSeq Version	NM_032409.2
Organism	Homo sapiens(human)
Definition	Homo sapiens PTEN induced putative kinase 1 (PINK1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032409.2

ORF Insert Sequence:

ATGGCGGTGC GACAGGCGCT GGGCCGCGGC CTGCAGCTGG GTCGAGCGCT GCTGCTGCGC 
TTCACGGGCA AGCCCGGCCG GGCCTACGGC TTGGGGCGGC CGGGCCCGGC GGCGGGCTGT 
GTCCGCGGGG AGCGTCCAGG CTGGGCCGCA GGACCGGGCG CGGAGCCTCG CAGGGTCGGG 
CTCGGGCTCC CTAACCGTCT CCGCTTCTTC CGCCAGTCGG TGGCCGGGCT GGCGGCGCGG 
TTGCAGCGGC AGTTCGTGGT GCGGGCCTGG GGCTGCGCGG GCCCTTGCGG CCGGGCAGTC 
TTTCTGGCCT TCGGGCTAGG GCTGGGCCTC ATCGAGGAAA AACAGGCGGA GAGCCGGCGG 
GCGGTCTCGG CCTGTCAGGA GATCCAGGCA ATTTTTACCC AGAAAAGCAA GCCGGGGCCT 
GACCCGTTGG ACACGAGACG CTTGCAGGGC TTTCGGCTGG AGGAGTATCT GATAGGGCAG 
TCCATTGGTA AGGGCTGCAG TGCTGCTGTG TATGAAGCCA CCATGCCTAC ATTGCCCCAG 
AACCTGGAGG TGACAAAGAG CACCGGGTTG CTTCCAGGGA GAGGCCCAGG TACCAGTGCA 
CCAGGAGAAG GGCAGGAGCG AGCTCCGGGG GCCCCTGCCT TCCCCTTGGC CATCAAGATG 
ATGTGGAACA TCTCGGCAGG TTCCTCCAGC GAAGCCATCT TGAACACAAT GAGCCAGGAG 
CTGGTCCCAG CGAGCCGAGT GGCCTTGGCT GGGGAGTATG GAGCAGTCAC TTACAGAAAA 
TCCAAGAGAG GTCCCAAGCA ACTAGCCCCT CACCCCAACA TCATCCGGGT TCTCCGCGCC 
TTCACCTCTT CCGTGCCGCT GCTGCCAGGG GCCCTGGTCG ACTACCCTGA TGTGCTGCCC 
TCACGCCTCC ACCCTGAAGG CCTGGGCCAT GGCCGGACGC TGTTCCTCGT TATGAAGAAC 
TATCCCTGTA CCCTGCGCCA GTACCTTTGT GTGAACACAC CCAGCCCCCG CCTCGCCGCC 
ATGATGCTGC TGCAGCTGCT GGAAGGCGTG GACCATCTGG TTCAACAGGG CATCGCGCAC 
AGAGACCTGA AATCCGACAA CATCCTTGTG GAGCTGGACC CAGACGGCTG CCCCTGGCTG 
GTGATCGCAG ATTTTGGCTG CTGCCTGGCT GATGAGAGCA TCGGCCTGCA GTTGCCCTTC 
AGCAGCTGGT ACGTGGATCG GGGCGGAAAC GGCTGTCTGA TGGCCCCAGA GGTGTCCACG 
GCCCGTCCTG GCCCCAGGGC AGTGATTGAC TACAGCAAGG CTGATGCCTG GGCAGTGGGA 
GCCATCGCCT ATGAAATCTT CGGGCTTGTC AATCCCTTCT ACGGCCAGGG CAAGGCCCAC 
CTTGAAAGCC GCAGCTACCA AGAGGCTCAG CTACCTGCAC TGCCCGAGTC AGTGCCTCCA 
GACGTGAGAC AGTTGGTGAG GGCACTGCTC CAGCGAGAGG CCAGCAAGAG ACCATCTGCC 
CGAGTAGCCG CAAATGTGCT TCATCTAAGC CTCTGGGGTG AACATATTCT AGCCCTGAAG 
AATCTGAAGT TAGACAAGAT GGTTGGCTGG CTCCTCCAAC AATCGGCCGC CACTTTGTTG 
GCCAACAGGC TCACAGAGAA GTGTTGTGTG GAAACAAAAA TGAAGATGCT CTTTCTGGCT 
AACCTGGAGT GTGAAACGCT CTGCCAGGCA GCCCTCCTCC TCTGCTCATG GAGGGCAGCC 
CTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

An invisible ubiquitin conformation is required for efficient phosphorylation by PINK1.
The EMBO journal36(24)3555-3572(2017 12)
Gladkova C,Schubert AF,Wagstaff JL,Pruneda JN,Freund SM,Komander D

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PINK1 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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