MRPL34 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MRPL34
Entrez Gene ID	64981
Full Name	mitochondrial ribosomal protein L34
Synonyms	L34mt
General protein information	Preferred Names mitochondrial ribosomal protein L34 Names 39S ribosomal protein L34, mitochondrial MRP-L34 mitochondrial large ribosomal subunit protein bL34m
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.11
Summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008].
Disorder MIM:	611840

mRNA and Protein(s)

mRNA	Protein	Name
NM_023937.4	NP_076426.1	39S ribosomal protein L34, mitochondrial
XM_011528189.2	XP_011526491.1	39S ribosomal protein L34, mitochondrial isoform X1
XM_011528189.1	XP_011526491.1	39S ribosomal protein L34, mitochondrial isoform X1
NM_023937.3	NP_076426.1	39S ribosomal protein L34, mitochondrial

Pathways from BioSystems

Homologies

Homo sapiens (human)	MRPL34	NP_076426.1
Mus musculus (house mouse)	Mrpl34	NP_444392.1
	MRPL34	XP_001113551.1
Rattus norvegicus (Norway rat)	Mrpl34	NP_001006966.1
Bos taurus (cattle)	MRPL34	NP_001103657.1
Pan troglodytes (chimpanzee)	MRPL34	XP_003316229.1

Gene Ontology
Bibliography

Related articles in PubMed

Structures of the human mitochondrial ribosome in native states of assembly.
Brown A, Rathore S, Kimanius D, Aibara S, Bai XC, Rorbach J, Amunts A, Ramakrishnan V
Nature structural & molecular biology24(10)866-869(2017 Oct)

Structure of the large ribosomal subunit from human mitochondria.
Brown A, Amunts A, Bai XC, Sugimoto Y, Edwards PC, Murshudov G, Scheres SHW, Ramakrishnan V
Science (New York, N.Y.)346(6210)718-722(2014 Nov)

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ
PloS one5(9)e12862(2010 Sep)

Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome.
Zhang Z, Gerstein M
Genomics81(5)468-80(2003 May)

The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders.
Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, Watanabe K, Tanaka T
Genomics77(1-2)65-70(2001 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

The following MRPL34 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MRPL34 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu32047	NM_023937.4 Latest version!	Homo sapiens mitochondrial ribosomal protein L34 (MRPL34), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu32047	XM_011528189.2 Latest version!	Homo sapiens mitochondrial ribosomal protein L34 (MRPL34), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu32047	XM_011528189.1	Homo sapiens mitochondrial ribosomal protein L34 (MRPL34), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu32047	NM_023937.3	Homo sapiens mitochondrial ribosomal protein L34 (MRPL34), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MRPL34 ( NM_023937.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_076426.1 Homo sapiens mitochondrial ribosomal protein L34 (MRPL34), mRNA.

Price & Availability↑

CloneID	OHu32047
Clone ID Related Accession (Same CDS sequence)	NM_023937.4 , XM_011528189.2 , XM_011528189.1 , NM_023937.3
Accession Version	NM_023937.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 279bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-28
Organism	Homo sapiens(human)
Product	39S ribosomal protein L34, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC010463.6. On Jun 2, 2019 this sequence version replaced NM_023937.3. ##Evidence-Data-START## Transcript exon combination :: SRR7346977.8579.1, BC000071.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTGTCT TGGCTGGATC CCTGTTGGGC CCCACGAGTA GGTCGGCAGC GTTGCTGGGT 
GGCAGGTGGC TCCAGCCCCG GGCCTGGCTG GGGTTCCCAG ACGCCTGGGG CCTCCCCACC 
CCGCAGCAGG CCCGGGGCAA GGCTCGCGGG AATGAGTATC AGCCGAGCAA CATCAAACGC 
AAGAACAAGC ACGGCTGGGT CCGGCGCCTG AGCACGCCGG CCGGCGTGCA GGTCATCCTT 
CGCCGAATGC TCAAGGGCCG CAAGTCGCTG AGCCATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_076426.1
CDS	22..300
Translation	MAVLAGSLLGPTSRSAALLGGRWLQPRAWLGFPDAWGLPTPQQARGKARGNEYQPSNIKRKNKHGWVRRLSTPAGVQVILRRMLKGRKSLSH

Target ORF information:

RefSeq Version	NM_023937.4
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein L34 (MRPL34), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_023937.4

ORF Insert Sequence:

ATGGCTGTCT TGGCTGGATC CCTGTTGGGC CCCACGAGTA GGTCGGCAGC GTTGCTGGGT 
GGCAGGTGGC TCCAGCCCCG GGCCTGGCTG GGGTTCCCAG ACGCCTGGGG CCTCCCCACC 
CCGCAGCAGG CCCGGGGCAA GGCTCGCGGG AATGAGTATC AGCCGAGCAA CATCAAACGC 
AAGAACAAGC ACGGCTGGGT CCGGCGCCTG AGCACGCCGG CCGGCGTGCA GGTCATCCTT 
CGCCGAATGC TCAAGGGCCG CAAGTCGCTG AGCCATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MRPL34 ( NM_023937.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_076426.1 Homo sapiens mitochondrial ribosomal protein L34 (MRPL34), mRNA.

Price & Availability↑

CloneID	OHu32047
Clone ID Related Accession (Same CDS sequence)	NM_023937.4 , XM_011528189.2 , XM_011528189.1 , NM_023937.3
Accession Version	NM_023937.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 279bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-17
Organism	Homo sapiens(human)
Product	39S ribosomal protein L34, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC010463.6. On Mar 6, 2008 this sequence version replaced NM_023937.2. ##Evidence-Data-START## Transcript exon combination :: BC021801.1, CD389547.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTGTCT TGGCTGGATC CCTGTTGGGC CCCACGAGTA GGTCGGCAGC GTTGCTGGGT 
GGCAGGTGGC TCCAGCCCCG GGCCTGGCTG GGGTTCCCAG ACGCCTGGGG CCTCCCCACC 
CCGCAGCAGG CCCGGGGCAA GGCTCGCGGG AATGAGTATC AGCCGAGCAA CATCAAACGC 
AAGAACAAGC ACGGCTGGGT CCGGCGCCTG AGCACGCCGG CCGGCGTGCA GGTCATCCTT 
CGCCGAATGC TCAAGGGCCG CAAGTCGCTG AGCCATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_076426.1
CDS	226..504
Translation	MAVLAGSLLGPTSRSAALLGGRWLQPRAWLGFPDAWGLPTPQQARGKARGNEYQPSNIKRKNKHGWVRRLSTPAGVQVILRRMLKGRKSLSH

Target ORF information:

RefSeq Version	NM_023937.3
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein L34 (MRPL34), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_023937.3

ORF Insert Sequence:

ATGGCTGTCT TGGCTGGATC CCTGTTGGGC CCCACGAGTA GGTCGGCAGC GTTGCTGGGT 
GGCAGGTGGC TCCAGCCCCG GGCCTGGCTG GGGTTCCCAG ACGCCTGGGG CCTCCCCACC 
CCGCAGCAGG CCCGGGGCAA GGCTCGCGGG AATGAGTATC AGCCGAGCAA CATCAAACGC 
AAGAACAAGC ACGGCTGGGT CCGGCGCCTG AGCACGCCGG CCGGCGTGCA GGTCATCCTT 
CGCCGAATGC TCAAGGGCCG CAAGTCGCTG AGCCATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MRPL34 ( XM_011528189.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011526491.1 Homo sapiens mitochondrial ribosomal protein L34 (MRPL34), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu32047
Clone ID Related Accession (Same CDS sequence)	NM_023937.4 , XM_011528189.2 , XM_011528189.1 , NM_023937.3
Accession Version	XM_011528189.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 279bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	39S ribosomal protein L34, mitochondrial isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011528189.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTGTCT TGGCTGGATC CCTGTTGGGC CCCACGAGTA GGTCGGCAGC GTTGCTGGGT 
GGCAGGTGGC TCCAGCCCCG GGCCTGGCTG GGGTTCCCAG ACGCCTGGGG CCTCCCCACC 
CCGCAGCAGG CCCGGGGCAA GGCTCGCGGG AATGAGTATC AGCCGAGCAA CATCAAACGC 
AAGAACAAGC ACGGCTGGGT CCGGCGCCTG AGCACGCCGG CCGGCGTGCA GGTCATCCTT 
CGCCGAATGC TCAAGGGCCG CAAGTCGCTG AGCCATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011526491.1
CDS	191..469
Translation	MAVLAGSLLGPTSRSAALLGGRWLQPRAWLGFPDAWGLPTPQQARGKARGNEYQPSNIKRKNKHGWVRRLSTPAGVQVILRRMLKGRKSLSH

Target ORF information:

RefSeq Version	XM_011528189.2
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein L34 (MRPL34), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011528189.2

ORF Insert Sequence:

ATGGCTGTCT TGGCTGGATC CCTGTTGGGC CCCACGAGTA GGTCGGCAGC GTTGCTGGGT 
GGCAGGTGGC TCCAGCCCCG GGCCTGGCTG GGGTTCCCAG ACGCCTGGGG CCTCCCCACC 
CCGCAGCAGG CCCGGGGCAA GGCTCGCGGG AATGAGTATC AGCCGAGCAA CATCAAACGC 
AAGAACAAGC ACGGCTGGGT CCGGCGCCTG AGCACGCCGG CCGGCGTGCA GGTCATCCTT 
CGCCGAATGC TCAAGGGCCG CAAGTCGCTG AGCCATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MRPL34 ( XM_011528189.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011526491.1 Homo sapiens mitochondrial ribosomal protein L34 (MRPL34), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu32047
Clone ID Related Accession (Same CDS sequence)	NM_023937.4 , XM_011528189.2 , XM_011528189.1 , NM_023937.3
Accession Version	XM_011528189.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 279bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	39S ribosomal protein L34, mitochondrial isoform X1
Comment

ATGGCTGTCT TGGCTGGATC CCTGTTGGGC CCCACGAGTA GGTCGGCAGC GTTGCTGGGT 
GGCAGGTGGC TCCAGCCCCG GGCCTGGCTG GGGTTCCCAG ACGCCTGGGG CCTCCCCACC 
CCGCAGCAGG CCCGGGGCAA GGCTCGCGGG AATGAGTATC AGCCGAGCAA CATCAAACGC 
AAGAACAAGC ACGGCTGGGT CCGGCGCCTG AGCACGCCGG CCGGCGTGCA GGTCATCCTT 
CGCCGAATGC TCAAGGGCCG CAAGTCGCTG AGCCATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011526491.1
Translation	MAVLAGSLLGPTSRSAALLGGRWLQPRAWLGFPDAWGLPTPQQARGKARGNEYQPSNIKRKNKHGWVRRLSTPAGVQVILRRMLKGRKSLSH

Target ORF information:

RefSeq Version	XM_011528189.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens mitochondrial ribosomal protein L34 (MRPL34), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011528189.1

ORF Insert Sequence:

ATGGCTGTCT TGGCTGGATC CCTGTTGGGC CCCACGAGTA GGTCGGCAGC GTTGCTGGGT 
GGCAGGTGGC TCCAGCCCCG GGCCTGGCTG GGGTTCCCAG ACGCCTGGGG CCTCCCCACC 
CCGCAGCAGG CCCGGGGCAA GGCTCGCGGG AATGAGTATC AGCCGAGCAA CATCAAACGC 
AAGAACAAGC ACGGCTGGGT CCGGCGCCTG AGCACGCCGG CCGGCGTGCA GGTCATCCTT 
CGCCGAATGC TCAAGGGCCG CAAGTCGCTG AGCCATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structures of the human mitochondrial ribosome in native states of assembly.
Nature structural & molecular biology24(10)866-869(2017 Oct)
Brown A,Rathore S,Kimanius D,Aibara S,Bai XC,Rorbach J,Amunts A,Ramakrishnan V

Structure of the large ribosomal subunit from human mitochondria.
Science (New York, N.Y.)346(6210)718-722(2014 Nov)
Brown A,Amunts A,Bai XC,Sugimoto Y,Edwards PC,Murshudov G,Scheres SHW,Ramakrishnan V

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
PloS one5(9)e12862(2010 Sep)
Hendrickson SL,Lautenberger JA,Chinn LW,Malasky M,Sezgin E,Kingsley LA,Goedert JJ,Kirk GD,Gomperts ED,Buchbinder SP,Troyer JL,O'Brien SJ

Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome.
Genomics81(5)468-80(2003 May)
Zhang Z,Gerstein M

The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders.
Genomics77(1-2)65-70(2001 Sep)
Kenmochi N,Suzuki T,Uechi T,Magoori M,Kuniba M,Higa S,Watanabe K,Tanaka T

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MRPL34 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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