MRPS15 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MRPS15
Entrez Gene ID	64960
Full Name	mitochondrial ribosomal protein S15
Synonyms	DC37,MPR-S15,RPMS15,S15mt
General protein information	Preferred Names mitochondrial ribosomal protein S15 Names 28S ribosomal protein S15, mitochondrial MRP-S15 mitochondrial small ribosomal subunit protein uS15m
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p34.3
Summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S15P family. The encoded protein is more than two times the size of its E. coli counterpart, with the 12S rRNA binding sites conserved. Between human and mouse, the encoded protein is the least conserved among small subunit ribosomal proteins. Pseudogenes corresponding to this gene are found on chromosomes 15q and 19q. [provided by RefSeq, Jul 2008].
Disorder MIM:	611979

mRNA and Protein(s)

mRNA	Protein	Name
NM_031280.3	NP_112570.2	28S ribosomal protein S15, mitochondrial
NM_031280.4	NP_112570.2	28S ribosomal protein S15, mitochondrial

Pathways from BioSystems

Homologies

Homo sapiens (human)	MRPS15	NP_112570.2
Pan troglodytes (chimpanzee)	MRPS15	XP_524665.2
Rattus norvegicus (Norway rat)	Mrps15	NP_001007654.1
Gallus gallus (chicken)	MRPS15	XP_001233592.2
Xenopus tropicalis (tropical clawed frog)	mrps15	NP_001017066.1
Canis lupus familiaris (dog)	MRPS15	XP_005629461.1
Bos taurus (cattle)	MRPS15	NP_001179130.1
Mus musculus (house mouse)	Mrps15	NP_079820.2
Danio rerio (zebrafish)	mrps15	NP_001002485.1
	MRPS15	XP_001111055.2

Gene Ontology
Bibliography

Related articles in PubMed

Ribosome. The structure of the human mitochondrial ribosome.
Amunts A, Brown A, Toots J, Scheres SHW, Ramakrishnan V
Science (New York, N.Y.)348(6230)95-98(2015 Apr)

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW
Cell149(6)1393-406(2012 Jun)

Genome-wide meta-analysis for severe diabetic retinopathy.
Grassi MA, Tikhomirov A, Ramalingam S, Below JE, Cox NJ, Nicolae DL
Human molecular genetics20(12)2472-81(2011 Jun)

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ
PloS one5(9)e12862(2010 Sep)

Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome.
Zhang Z, Gerstein M
Genomics81(5)468-80(2003 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

The following MRPS15 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MRPS15 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09068	NM_031280.4 Latest version!	Homo sapiens mitochondrial ribosomal protein S15 (MRPS15), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu09068	NM_031280.3	Homo sapiens mitochondrial ribosomal protein S15 (MRPS15), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MRPS15 ( NM_031280.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_112570.2 Homo sapiens mitochondrial ribosomal protein S15 (MRPS15), mRNA.

Price & Availability↑

CloneID	OHu09068
Clone ID Related Accession (Same CDS sequence)	NM_031280.3 , NM_031280.4
Accession Version	NM_031280.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 774bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	28S ribosomal protein S15, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM048518.1, AK315441.1, BU927793.1, BC031336.1 and CF123360.1. On Apr 29, 2008 this sequence version replaced NM_031280.2. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.214543.1, SRR1803616.469393.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTGAGGG TCGCGTGGAG GACGCTGAGT TTGATTCGGA CCCGGGCAGT TACCCAGGTC 
CTAGTACCCG GGCTGCCGGG CGGTGGGAGC GCCAAGTTTC CTTTCAACCA GTGGGGCCTG 
CAGCCTCGAA GTCTCCTCCT CCAGGCCGCG CGCGGATATG TCGTCCGGAA ACCAGCCCAG 
TCTAGGCTGG ATGATGACCC ACCTCCCTCT ACGCTGCTCA AAGACTACCA GAATGTCCCT 
GGAATTGAGA AGGTTGATGA TGTCGTGAAA AGACTCTTGT CTTTGGAAAT GGCCAACAAG 
AAGGAGATGC TAAAAATCAA GCAAGAACAG TTTATGAAGA AGATTGTTGC AAACCCAGAG 
GACACCAGAT CCCTGGAGGC TCGAATTATT GCCTTGTCTG TCAAGATCCG CAGTTATGAA 
GAACACTTGG AGAAACATCG AAAGGACAAA GCCCACAAAC GCTATCTGCT AATGAGCATT 
GACCAGAGGA AAAAGATGCT CAAAAACCTC CGTAACACCA ACTATGATGT CTTTGAGAAG 
ATATGCTGGG GGCTGGGAAT TGAGTACACC TTCCCCCCTC TGTATTACCG AAGAGCCCAC 
CGCCGATTCG TGACCAAGAA GGCTCTGTGC ATTCGGGTTT TCCAGGAGAC TCAAAAGCTG 
AAGAAGCGAA GAAGAGCCTT AAAGGCTGCA GCAGCAGCCC AAAAACAAGC AAAGCGGAGG 
AACCCAGACA GCCCTGCCAA AGCCATACCA AAGACACTCA AAGACAGCCA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112570.2
CDS	165..938
Translation	MLRVAWRTLSLIRTRAVTQVLVPGLPGGGSAKFPFNQWGLQPRSLLLQAARGYVVRKPAQSRLDDDPPPSTLLKDYQNVPGIEKVDDVVKRLLSLEMANKKEMLKIKQEQFMKKIVANPEDTRSLEARIIALSVKIRSYEEHLEKHRKDKAHKRYLLMSIDQRKKMLKNLRNTNYDVFEKICWGLGIEYTFPPLYYRRAHRRFVTKKALCIRVFQETQKLKKRRRALKAAAAAQKQAKRRNPDSPAKAIPKTLKDSQ

Target ORF information:

RefSeq Version	NM_031280.3
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein S15 (MRPS15), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031280.3

ORF Insert Sequence:

ATGCTGAGGG TCGCGTGGAG GACGCTGAGT TTGATTCGGA CCCGGGCAGT TACCCAGGTC 
CTAGTACCCG GGCTGCCGGG CGGTGGGAGC GCCAAGTTTC CTTTCAACCA GTGGGGCCTG 
CAGCCTCGAA GTCTCCTCCT CCAGGCCGCG CGCGGATATG TCGTCCGGAA ACCAGCCCAG 
TCTAGGCTGG ATGATGACCC ACCTCCCTCT ACGCTGCTCA AAGACTACCA GAATGTCCCT 
GGAATTGAGA AGGTTGATGA TGTCGTGAAA AGACTCTTGT CTTTGGAAAT GGCCAACAAG 
AAGGAGATGC TAAAAATCAA GCAAGAACAG TTTATGAAGA AGATTGTTGC AAACCCAGAG 
GACACCAGAT CCCTGGAGGC TCGAATTATT GCCTTGTCTG TCAAGATCCG CAGTTATGAA 
GAACACTTGG AGAAACATCG AAAGGACAAA GCCCACAAAC GCTATCTGCT AATGAGCATT 
GACCAGAGGA AAAAGATGCT CAAAAACCTC CGTAACACCA ACTATGATGT CTTTGAGAAG 
ATATGCTGGG GGCTGGGAAT TGAGTACACC TTCCCCCCTC TGTATTACCG AAGAGCCCAC 
CGCCGATTCG TGACCAAGAA GGCTCTGTGC ATTCGGGTTT TCCAGGAGAC TCAAAAGCTG 
AAGAAGCGAA GAAGAGCCTT AAAGGCTGCA GCAGCAGCCC AAAAACAAGC AAAGCGGAGG 
AACCCAGACA GCCCTGCCAA AGCCATACCA AAGACACTCA AAGACAGCCA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MRPS15 ( NM_031280.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_112570.2 Homo sapiens mitochondrial ribosomal protein S15 (MRPS15), mRNA.

Price & Availability↑

CloneID	OHu09068
Clone ID Related Accession (Same CDS sequence)	NM_031280.3 , NM_031280.4
Accession Version	NM_031280.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 774bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	28S ribosomal protein S15, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM048518.1, AK315441.1, BU927793.1, BC031336.1, CF123360.1 and AC119675.2. On Nov 23, 2018 this sequence version replaced NM_031280.3. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.13348.1, SRR1163655.141306.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000373116.6/ ENSP00000362208.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTGAGGG TCGCGTGGAG GACGCTGAGT TTGATTCGGA CCCGGGCAGT TACCCAGGTC 
CTAGTACCCG GGCTGCCGGG CGGTGGGAGC GCCAAGTTTC CTTTCAACCA GTGGGGCCTG 
CAGCCTCGAA GTCTCCTCCT CCAGGCCGCG CGCGGATATG TCGTCCGGAA ACCAGCCCAG 
TCTAGGCTGG ATGATGACCC ACCTCCCTCT ACGCTGCTCA AAGACTACCA GAATGTCCCT 
GGAATTGAGA AGGTTGATGA TGTCGTGAAA AGACTCTTGT CTTTGGAAAT GGCCAACAAG 
AAGGAGATGC TAAAAATCAA GCAAGAACAG TTTATGAAGA AGATTGTTGC AAACCCAGAG 
GACACCAGAT CCCTGGAGGC TCGAATTATT GCCTTGTCTG TCAAGATCCG CAGTTATGAA 
GAACACTTGG AGAAACATCG AAAGGACAAA GCCCACAAAC GCTATCTGCT AATGAGCATT 
GACCAGAGGA AAAAGATGCT CAAAAACCTC CGTAACACCA ACTATGATGT CTTTGAGAAG 
ATATGCTGGG GGCTGGGAAT TGAGTACACC TTCCCCCCTC TGTATTACCG AAGAGCCCAC 
CGCCGATTCG TGACCAAGAA GGCTCTGTGC ATTCGGGTTT TCCAGGAGAC TCAAAAGCTG 
AAGAAGCGAA GAAGAGCCTT AAAGGCTGCA GCAGCAGCCC AAAAACAAGC AAAGCGGAGG 
AACCCAGACA GCCCTGCCAA AGCCATACCA AAGACACTCA AAGACAGCCA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112570.2
CDS	110..883
Translation	MLRVAWRTLSLIRTRAVTQVLVPGLPGGGSAKFPFNQWGLQPRSLLLQAARGYVVRKPAQSRLDDDPPPSTLLKDYQNVPGIEKVDDVVKRLLSLEMANKKEMLKIKQEQFMKKIVANPEDTRSLEARIIALSVKIRSYEEHLEKHRKDKAHKRYLLMSIDQRKKMLKNLRNTNYDVFEKICWGLGIEYTFPPLYYRRAHRRFVTKKALCIRVFQETQKLKKRRRALKAAAAAQKQAKRRNPDSPAKAIPKTLKDSQ

Target ORF information:

RefSeq Version	NM_031280.4
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein S15 (MRPS15), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031280.4

ORF Insert Sequence:

ATGCTGAGGG TCGCGTGGAG GACGCTGAGT TTGATTCGGA CCCGGGCAGT TACCCAGGTC 
CTAGTACCCG GGCTGCCGGG CGGTGGGAGC GCCAAGTTTC CTTTCAACCA GTGGGGCCTG 
CAGCCTCGAA GTCTCCTCCT CCAGGCCGCG CGCGGATATG TCGTCCGGAA ACCAGCCCAG 
TCTAGGCTGG ATGATGACCC ACCTCCCTCT ACGCTGCTCA AAGACTACCA GAATGTCCCT 
GGAATTGAGA AGGTTGATGA TGTCGTGAAA AGACTCTTGT CTTTGGAAAT GGCCAACAAG 
AAGGAGATGC TAAAAATCAA GCAAGAACAG TTTATGAAGA AGATTGTTGC AAACCCAGAG 
GACACCAGAT CCCTGGAGGC TCGAATTATT GCCTTGTCTG TCAAGATCCG CAGTTATGAA 
GAACACTTGG AGAAACATCG AAAGGACAAA GCCCACAAAC GCTATCTGCT AATGAGCATT 
GACCAGAGGA AAAAGATGCT CAAAAACCTC CGTAACACCA ACTATGATGT CTTTGAGAAG 
ATATGCTGGG GGCTGGGAAT TGAGTACACC TTCCCCCCTC TGTATTACCG AAGAGCCCAC 
CGCCGATTCG TGACCAAGAA GGCTCTGTGC ATTCGGGTTT TCCAGGAGAC TCAAAAGCTG 
AAGAAGCGAA GAAGAGCCTT AAAGGCTGCA GCAGCAGCCC AAAAACAAGC AAAGCGGAGG 
AACCCAGACA GCCCTGCCAA AGCCATACCA AAGACACTCA AAGACAGCCA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ribosome. The structure of the human mitochondrial ribosome.
Science (New York, N.Y.)348(6230)95-98(2015 Apr)
Amunts A,Brown A,Toots J,Scheres SHW,Ramakrishnan V

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Cell149(6)1393-406(2012 Jun)
Castello A,Fischer B,Eichelbaum K,Horos R,Beckmann BM,Strein C,Davey NE,Humphreys DT,Preiss T,Steinmetz LM,Krijgsveld J,Hentze MW

Genome-wide meta-analysis for severe diabetic retinopathy.
Human molecular genetics20(12)2472-81(2011 Jun)
Grassi MA,Tikhomirov A,Ramalingam S,Below JE,Cox NJ,Nicolae DL

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
PloS one5(9)e12862(2010 Sep)
Hendrickson SL,Lautenberger JA,Chinn LW,Malasky M,Sezgin E,Kingsley LA,Goedert JJ,Kirk GD,Gomperts ED,Buchbinder SP,Troyer JL,O'Brien SJ

Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome.
Genomics81(5)468-80(2003 May)
Zhang Z,Gerstein M

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MRPS15 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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