PRSS56 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PRSS56
Entrez Gene ID	646960
Full Name	serine protease 56
Synonyms	MCOP6
General protein information	Preferred Names serine protease 56 Names serine protease 56 protease, serine 56 putative serine protease 56
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q37.1
Summary	This gene encodes a protein that contains a peptidase S1 domain and possesses trypsin-like serine protease activity. The encoded protein may play a role in eye development, and mutations in this gene are a cause of autosomal recessive posterior microphthalmos. [provided by RefSeq, Dec 2011].
Disorder MIM:	613858
Disorder Html:	Microphthalmia, isolated 6, 613517 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001369848.1	NP_001356777.1	serine protease 56 isoform 1 precursor
NM_001195129.1	NP_001182058.1	serine protease 56 isoform 2 precursor
NM_001195129.2	NP_001182058.1	serine protease 56 isoform 2 precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Prss56	NP_081360.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004571	XP_313875.2
Homo sapiens (human)	PRSS56	NP_001182058.1
Pan troglodytes (chimpanzee)	PRSS56	XP_001143010.1
Rattus norvegicus (Norway rat)	Prss56	XP_003750778.1
Gallus gallus (chicken)	PRSS56	XP_422746.4
	LOC717558	XP_001109183.2
Canis lupus familiaris (dog)	PRSS56	XP_005635909.1
Bos taurus (cattle)	PRSS56	XP_003585836.1
Drosophila melanogaster (fruit fly)	CG4914	NP_648711.1
Xenopus tropicalis (tropical clawed frog)	prss56	XP_004914443.1

Gene Ontology
Bibliography

Related articles in PubMed

Posterior microphthalmia and nanophthalmia in Tunisia caused by a founder c.1059_1066insC mutation of the PRSS56 gene.
Said MB, Chouch?ne E, Salem SB, Daoud K, Largueche L, Bouassida W, Benzina Z, Ayadi H, S?derkvist P, Matri L, Hmani-Aifa M
Gene528(2)288-94(2013 Oct)

Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia.
Verhoeven VJ, Hysi PG, Wojciechowski R, Fan Q, Guggenheim JA, H?hn R, MacGregor S, Hewitt AW, Nag A, Cheng CY, Yonova-Doing E, Zhou X, Ikram MK, Buitendijk GH, McMahon G, Kemp JP, Pourcain BS, Simpson CL, M?kel? KM, Lehtim?ki T, K?h?nen M, Paterson AD, Hosseini SM, Wong HS, Xu L, Jonas JB, P?rssinen O, Wedenoja J, Yip SP, Ho DW, Pang CP, Chen LJ, Burdon KP, Craig JE, Klein BE, Klein R, Haller T, Metspalu A, Khor CC, Tai ES, Aung T, Vithana E, Tay WT, Barathi VA, , Chen P, Li R, Liao J, Zheng Y, Ong RT, D?ring A, , Evans DM, Timpson NJ, Verkerk AJ, Meitinger T, Raitakari O, Hawthorne F, Spector TD, Karssen LC, Pirastu M, Murgia F, Ang W, , Mishra A, Montgomery GW, Pennell CE, Cumberland PM, Cotlarciuc I, Mitchell P, Wang JJ, Schache M, Janmahasatian S, Janmahasathian S, Igo RP Jr, Lass JH, Chew E, Iyengar SK, , Gorgels TG, Rudan I, Hayward C, Wright AF, Polasek O, Vatavuk Z, Wilson JF, Fleck B, Zeller T, Mirshahi A, M?ller C, Uitterlinden AG, Rivadeneira F, Vingerling JR, Hofman A, Oostra BA, Amin N, Bergen AA, Teo YY, Rahi JS, Vitart V, Williams C, Baird PN, Wong TY, Oexle K, Pfeiffer N, Mackey DA, Young TL, van Duijn CM, Saw SM, Bailey-Wilson JE, Stambolian D, Klaver CC, Hammond CJ
Nature genetics45(3)314-8(2013 Mar)

Biometric and molecular characterization of clinically diagnosed posterior microphthalmos.
Nowilaty SR, Khan AO, Aldahmesh MA, Tabbara KF, Al-Amri A, Alkuraya FS
American journal of ophthalmology155(2)361-372.e7(2013 Feb)

Evaluation of PRSS56 in Chinese subjects with high hyperopia or primary angle-closure glaucoma.
Jiang D, Yang Z, Li S, Xiao X, Jia X, Wang P, Guo X, Liu X, Zhang Q
Molecular vision192217-26(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Idenification of a founder mutation in the PRSS56 gene in Tunisian families with posterior microphthalmia and nanophthalmia.
Title: Posterior microphthalmia and nanophthalmia in Tunisia caused by a founder c.1059_1066insC mutation of the PRSS56 gene.

Corneal diameter decreases with decreasing axial length, suggesting posterior microphthalmos and nanophthalmos represent a spectrum of high hyperopia rather than distinct phenotypes. In the Saudi population PRSS56 mutations are the major cause.
Title: Biometric and molecular characterization of clinically diagnosed posterior microphthalmos.

variations in PRSS56 were evaluated in patients with either primary angle-closure glaucoma (PACG) or high hyperopia.
Title: Evaluation of PRSS56 in Chinese subjects with high hyperopia or primary angle-closure glaucoma.

Together, these data suggest that alterations of this serine protease may contribute to a spectrum of human ocular conditions including reduced ocular size and ACG.
Title: Alteration of the serine protease PRSS56 causes angle-closure glaucoma in mice and posterior microphthalmia in humans and mice.

PRSS56 is a good candidate for the causal gene for nanophthalmos in a Mexican-Canadian family cohort.
Title: Mutations in a novel serine protease PRSS56 in families with nanophthalmos.

The following PRSS56 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PRSS56 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu20505	NM_001195129.2 Latest version!	Homo sapiens serine protease 56 (PRSS56), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu108038	NM_001369848.1 Latest version!	Homo sapiens serine protease 56 (PRSS56), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
View Old Accession Versions >>
OHu20505	NM_001195129.1	Homo sapiens serine protease 56 (PRSS56), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PRSS56 ( NM_001195129.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001182058.1 Homo sapiens serine protease 56 (PRSS56), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu20505
Clone ID Related Accession (Same CDS sequence)	NM_001195129.1 , NM_001195129.2
Accession Version	NM_001195129.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1812bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-30
Organism	Homo sapiens(human)
Product	serine protease 56 isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC092165.4. This sequence is a reference standard in the RefSeqGene project. On or before Aug 25, 2010 this sequence version replaced XM_929928.3, XM_939623.3, XM_001720729.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence because no single transcript was available for the full length of the gene. The genomic coordinates used for the transcript record were based on transcript and protein alignments, including the full-length mouse transcript JF323950.1. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA2152474, SAMN03267755 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: PMID: 21397065 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END##

ATGCTGCTGG CTGTGCTGCT GCTGCTACCC CTCCCAAGCT CATGGTTTGC CCACGGGCAC 
CCACTGTACA CACGCCTGCC CCCCAGCGCC CTGCAAGTTC TGTCGGCCCA GGGGACTCAG 
GCGTTGCAGG CAGCCCAGAG GAGCGCCCAG TGGGCAATAA ACCGAGTGGC GATGGAGATC 
CAGCACAGAT CGCACGAGTG CCGAGGATCT GGGCGCCCCA GGCCTCAAGC TCTCCTCCAG 
GACCCACCTG AGCCAGGGCC GTGCGGCGAG AGGCGTCCGA GCACTGCCAA TGTGACGCGG 
GCCCACGGCC GCATCGTGGG GGGCAGCGCG GCGCCGCCCG GGGCCTGGCC CTGGCTGGTG 
AGGCTGCAGC TCGGCGGGCA GCCTCTGTGC GGCGGCGTCC TGGTAGCGGC CTCCTGGGTG 
CTCACGGCAG CGCACTGCTT TGTAGGCGCC CCGAATGAGC TTCTGTGGAC TGTGACGCTG 
GCAGAGGGGT CCCGGGGGGA GCAAGCGGAG GAGGTGCCAG TGAACCGCAT CCTGCCCCAC 
CCCAAGTTTG ACCCGCGGAC CTTCCACAAC GACCTGGCCC TGGTGCAGCT GTGGACGCCG 
GTGAGCCCGG GGGGATCGGC GCGCCCCGTG TGCCTGCCCC AGGAGCCCCA GGAGCCCCCT 
GCCGGAACCG CCTGCGCCAT CGCGGGCTGG GGCGCCCTCT TCGAAGACGG GCCTGAGGCT 
GAAGCAGTGA GAGAGGCCCG TGTTCCCCTG CTCAGCACCG ACACCTGCCG AAGAGCCCTG 
GGGCCCGGGC TGCGCCCCAG CACCATGCTC TGCGCCGGGT ACCTGGCGGG GGGCGTTGAC 
TCGTGCCAGG GTGACTCGGG AGGCCCCCTG ACCTGTTCTG AGCCTGGCCC CCGCCCTAGA 
GAGGTCCTGT TCGGAGTCAC CTCCTGGGGG GACGGCTGCG GGGAGCCAGG GAAGCCCGGG 
GTCTACACCC GCGTGGCAGT GTTCAAGGAC TGGCTCCAGG AGCAGATGAG CGCCTCCTCC 
AGCCGCGAGC CCAGCTGCAG GGAGCTTCTG GCCTGGGACC CCCCCCAGGA GCTGCAGGCA 
GACGCCGCCC GGCTCTGCGC CTTCTATGCC CGCCTGTGCC CGGGGTCCCA GGGCGCCTGT 
GCGCGCCTGG CGCACCAGCA GTGCCTGCAG CGCCGGCGGC GATGCGAGCT GCGCTCGCTG 
GCGCACACGC TGCTGGGCCT GCTGCGGAAC GCGCAGGAGC TGCTCGGGCC TCGTCCGGGA 
CTGCGGCGCC TGGCCCCCGC CCTGGCTCTC CCCGCTCCAG CGCTCAGGGA GTCTCCTCTG 
CACCCCGCCC GGGAGCTGCG GCTTCACTCA GGATCGCGGG CTGCAGGCAC TCGGTTCCCG 
AAGCGGAGGC CGGAGCCGCG CGGAGAAGCC AACGGCTGCC CTGGGCTGGA GCCCCTGCGA 
CAGAAGTTGG CTGCCCTGCA GGGGGCCCAT GCCTGGATCC TGCAGGTCCC CTCGGAGCAC 
CTGGCCATGA ACTTTCATGA GGTCCTGGCA GATCTGGGCT CCAAGACACT GACCGGGCTT 
TTCAGAGCCT GGGTGCGGGC AGGCTTGGGG GGCCGGCATG TGGCCTTCAG CGGCCTGGTG 
GGCCTGGAGC CGGCCACACT GGCTCGCAGC CTCCCCCGGC TGCTGGTGCA GGCCCTGCAG 
GCCTTCCGCG TGGCTGCCCT GGCAGAAGGG GAGCCCGAGG GACCCTGGAT GGATGTAGGG 
CAGGGGCCCG GGCTGGAGAG GAAGGGGCAC CACCCACTCA ACCCTCAGGT ACCCCCCGCC 
AGGCAACCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001182058.1
CDS	137..1948
Translation	MLLAVLLLLPLPSSWFAHGHPLYTRLPPSALQVLSAQGTQALQAAQRSAQWAINRVAMEIQHRSHECRGSGRPRPQALLQDPPEPGPCGERRPSTANVTRAHGRIVGGSAAPPGAWPWLVRLQLGGQPLCGGVLVAASWVLTAAHCFVGAPNELLWTVTLAEGSRGEQAEEVPVNRILPHPKFDPRTFHNDLALVQLWTPVSPGGSARPVCLPQEPQEPPAGTACAIAGWGALFEDGPEAEAVREARVPLLSTDTCRRALGPGLRPSTMLCAGYLAGGVDSCQGDSGGPLTCSEPGPRPREVLFGVTSWGDGCGEPGKPGVYTRVAVFKDWLQEQMSASSSREPSCRELLAWDPPQELQADAARLCAFYARLCPGSQGACARLAHQQCLQRRRRCELRSLAHTLLGLLRNAQELLGPRPGLRRLAPALALPAPALRESPLHPARELRLHSGSRAAGTRFPKRRPEPRGEANGCPGLEPLRQKLAALQGAHAWILQVPSEHLAMNFHEVLADLGSKTLTGLFRAWVRAGLGGRHVAFSGLVGLEPATLARSLPRLLVQALQAFRVAALAEGEPEGPWMDVGQGPGLERKGHHPLNPQVPPARQP

Target ORF information:

RefSeq Version	NM_001195129.1
Organism	Homo sapiens(human)
Definition	Homo sapiens serine protease 56 (PRSS56), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001195129.1

ORF Insert Sequence:

ATGCTGCTGG CTGTGCTGCT GCTGCTACCC CTCCCAAGCT CATGGTTTGC CCACGGGCAC 
CCACTGTACA CACGCCTGCC CCCCAGCGCC CTGCAAGTTC TGTCGGCCCA GGGGACTCAG 
GCGTTGCAGG CAGCCCAGAG GAGCGCCCAG TGGGCAATAA ACCGAGTGGC GATGGAGATC 
CAGCACAGAT CGCACGAGTG CCGAGGATCT GGGCGCCCCA GGCCTCAAGC TCTCCTCCAG 
GACCCACCTG AGCCAGGGCC GTGCGGCGAG AGGCGTCCGA GCACTGCCAA TGTGACGCGG 
GCCCACGGCC GCATCGTGGG GGGCAGCGCG GCGCCGCCCG GGGCCTGGCC CTGGCTGGTG 
AGGCTGCAGC TCGGCGGGCA GCCTCTGTGC GGCGGCGTCC TGGTAGCGGC CTCCTGGGTG 
CTCACGGCAG CGCACTGCTT TGTAGGCGCC CCGAATGAGC TTCTGTGGAC TGTGACGCTG 
GCAGAGGGGT CCCGGGGGGA GCAAGCGGAG GAGGTGCCAG TGAACCGCAT CCTGCCCCAC 
CCCAAGTTTG ACCCGCGGAC CTTCCACAAC GACCTGGCCC TGGTGCAGCT GTGGACGCCG 
GTGAGCCCGG GGGGATCGGC GCGCCCCGTG TGCCTGCCCC AGGAGCCCCA GGAGCCCCCT 
GCCGGAACCG CCTGCGCCAT CGCGGGCTGG GGCGCCCTCT TCGAAGACGG GCCTGAGGCT 
GAAGCAGTGA GAGAGGCCCG TGTTCCCCTG CTCAGCACCG ACACCTGCCG AAGAGCCCTG 
GGGCCCGGGC TGCGCCCCAG CACCATGCTC TGCGCCGGGT ACCTGGCGGG GGGCGTTGAC 
TCGTGCCAGG GTGACTCGGG AGGCCCCCTG ACCTGTTCTG AGCCTGGCCC CCGCCCTAGA 
GAGGTCCTGT TCGGAGTCAC CTCCTGGGGG GACGGCTGCG GGGAGCCAGG GAAGCCCGGG 
GTCTACACCC GCGTGGCAGT GTTCAAGGAC TGGCTCCAGG AGCAGATGAG CGCCTCCTCC 
AGCCGCGAGC CCAGCTGCAG GGAGCTTCTG GCCTGGGACC CCCCCCAGGA GCTGCAGGCA 
GACGCCGCCC GGCTCTGCGC CTTCTATGCC CGCCTGTGCC CGGGGTCCCA GGGCGCCTGT 
GCGCGCCTGG CGCACCAGCA GTGCCTGCAG CGCCGGCGGC GATGCGAGCT GCGCTCGCTG 
GCGCACACGC TGCTGGGCCT GCTGCGGAAC GCGCAGGAGC TGCTCGGGCC TCGTCCGGGA 
CTGCGGCGCC TGGCCCCCGC CCTGGCTCTC CCCGCTCCAG CGCTCAGGGA GTCTCCTCTG 
CACCCCGCCC GGGAGCTGCG GCTTCACTCA GGATCGCGGG CTGCAGGCAC TCGGTTCCCG 
AAGCGGAGGC CGGAGCCGCG CGGAGAAGCC AACGGCTGCC CTGGGCTGGA GCCCCTGCGA 
CAGAAGTTGG CTGCCCTGCA GGGGGCCCAT GCCTGGATCC TGCAGGTCCC CTCGGAGCAC 
CTGGCCATGA ACTTTCATGA GGTCCTGGCA GATCTGGGCT CCAAGACACT GACCGGGCTT 
TTCAGAGCCT GGGTGCGGGC AGGCTTGGGG GGCCGGCATG TGGCCTTCAG CGGCCTGGTG 
GGCCTGGAGC CGGCCACACT GGCTCGCAGC CTCCCCCGGC TGCTGGTGCA GGCCCTGCAG 
GCCTTCCGCG TGGCTGCCCT GGCAGAAGGG GAGCCCGAGG GACCCTGGAT GGATGTAGGG 
CAGGGGCCCG GGCTGGAGAG GAAGGGGCAC CACCCACTCA ACCCTCAGGT ACCCCCCGCC 
AGGCAACCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PRSS56 ( NM_001195129.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001182058.1 Homo sapiens serine protease 56 (PRSS56), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu20505
Clone ID Related Accession (Same CDS sequence)	NM_001195129.1 , NM_001195129.2
Accession Version	NM_001195129.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1812bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	serine protease 56 isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC092165.4. This sequence is a reference standard in the RefSeqGene project. On Jul 25, 2019 this sequence version replaced NM_001195129.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence because no single transcript was available for the full length of the gene. The genomic coordinates used for the transcript record were based on transcript and protein alignments, including the full-length mouse transcript JF323950.1. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression ##RefSeq-Attributes-END##

ATGCTGCTGG CTGTGCTGCT GCTGCTACCC CTCCCAAGCT CATGGTTTGC CCACGGGCAC 
CCACTGTACA CACGCCTGCC CCCCAGCGCC CTGCAAGTTC TGTCGGCCCA GGGGACTCAG 
GCGTTGCAGG CAGCCCAGAG GAGCGCCCAG TGGGCAATAA ACCGAGTGGC GATGGAGATC 
CAGCACAGAT CGCACGAGTG CCGAGGATCT GGGCGCCCCA GGCCTCAAGC TCTCCTCCAG 
GACCCACCTG AGCCAGGGCC GTGCGGCGAG AGGCGTCCGA GCACTGCCAA TGTGACGCGG 
GCCCACGGCC GCATCGTGGG GGGCAGCGCG GCGCCGCCCG GGGCCTGGCC CTGGCTGGTG 
AGGCTGCAGC TCGGCGGGCA GCCTCTGTGC GGCGGCGTCC TGGTAGCGGC CTCCTGGGTG 
CTCACGGCAG CGCACTGCTT TGTAGGCGCC CCGAATGAGC TTCTGTGGAC TGTGACGCTG 
GCAGAGGGGT CCCGGGGGGA GCAAGCGGAG GAGGTGCCAG TGAACCGCAT CCTGCCCCAC 
CCCAAGTTTG ACCCGCGGAC CTTCCACAAC GACCTGGCCC TGGTGCAGCT GTGGACGCCG 
GTGAGCCCGG GGGGATCGGC GCGCCCCGTG TGCCTGCCCC AGGAGCCCCA GGAGCCCCCT 
GCCGGAACCG CCTGCGCCAT CGCGGGCTGG GGCGCCCTCT TCGAAGACGG GCCTGAGGCT 
GAAGCAGTGA GAGAGGCCCG TGTTCCCCTG CTCAGCACCG ACACCTGCCG AAGAGCCCTG 
GGGCCCGGGC TGCGCCCCAG CACCATGCTC TGCGCCGGGT ACCTGGCGGG GGGCGTTGAC 
TCGTGCCAGG GTGACTCGGG AGGCCCCCTG ACCTGTTCTG AGCCTGGCCC CCGCCCTAGA 
GAGGTCCTGT TCGGAGTCAC CTCCTGGGGG GACGGCTGCG GGGAGCCAGG GAAGCCCGGG 
GTCTACACCC GCGTGGCAGT GTTCAAGGAC TGGCTCCAGG AGCAGATGAG CGCCTCCTCC 
AGCCGCGAGC CCAGCTGCAG GGAGCTTCTG GCCTGGGACC CCCCCCAGGA GCTGCAGGCA 
GACGCCGCCC GGCTCTGCGC CTTCTATGCC CGCCTGTGCC CGGGGTCCCA GGGCGCCTGT 
GCGCGCCTGG CGCACCAGCA GTGCCTGCAG CGCCGGCGGC GATGCGAGCT GCGCTCGCTG 
GCGCACACGC TGCTGGGCCT GCTGCGGAAC GCGCAGGAGC TGCTCGGGCC TCGTCCGGGA 
CTGCGGCGCC TGGCCCCCGC CCTGGCTCTC CCCGCTCCAG CGCTCAGGGA GTCTCCTCTG 
CACCCCGCCC GGGAGCTGCG GCTTCACTCA GGATCGCGGG CTGCAGGCAC TCGGTTCCCG 
AAGCGGAGGC CGGAGCCGCG CGGAGAAGCC AACGGCTGCC CTGGGCTGGA GCCCCTGCGA 
CAGAAGTTGG CTGCCCTGCA GGGGGCCCAT GCCTGGATCC TGCAGGTCCC CTCGGAGCAC 
CTGGCCATGA ACTTTCATGA GGTCCTGGCA GATCTGGGCT CCAAGACACT GACCGGGCTT 
TTCAGAGCCT GGGTGCGGGC AGGCTTGGGG GGCCGGCATG TGGCCTTCAG CGGCCTGGTG 
GGCCTGGAGC CGGCCACACT GGCTCGCAGC CTCCCCCGGC TGCTGGTGCA GGCCCTGCAG 
GCCTTCCGCG TGGCTGCCCT GGCAGAAGGG GAGCCCGAGG GACCCTGGAT GGATGTAGGG 
CAGGGGCCCG GGCTGGAGAG GAAGGGGCAC CACCCACTCA ACCCTCAGGT ACCCCCCGCC 
AGGCAACCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001182058.1
CDS	212..2023
Translation	MLLAVLLLLPLPSSWFAHGHPLYTRLPPSALQVLSAQGTQALQAAQRSAQWAINRVAMEIQHRSHECRGSGRPRPQALLQDPPEPGPCGERRPSTANVTRAHGRIVGGSAAPPGAWPWLVRLQLGGQPLCGGVLVAASWVLTAAHCFVGAPNELLWTVTLAEGSRGEQAEEVPVNRILPHPKFDPRTFHNDLALVQLWTPVSPGGSARPVCLPQEPQEPPAGTACAIAGWGALFEDGPEAEAVREARVPLLSTDTCRRALGPGLRPSTMLCAGYLAGGVDSCQGDSGGPLTCSEPGPRPREVLFGVTSWGDGCGEPGKPGVYTRVAVFKDWLQEQMSASSSREPSCRELLAWDPPQELQADAARLCAFYARLCPGSQGACARLAHQQCLQRRRRCELRSLAHTLLGLLRNAQELLGPRPGLRRLAPALALPAPALRESPLHPARELRLHSGSRAAGTRFPKRRPEPRGEANGCPGLEPLRQKLAALQGAHAWILQVPSEHLAMNFHEVLADLGSKTLTGLFRAWVRAGLGGRHVAFSGLVGLEPATLARSLPRLLVQALQAFRVAALAEGEPEGPWMDVGQGPGLERKGHHPLNPQVPPARQP

Target ORF information:

RefSeq Version	NM_001195129.2
Organism	Homo sapiens(human)
Definition	Homo sapiens serine protease 56 (PRSS56), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001195129.2

ORF Insert Sequence:

ATGCTGCTGG CTGTGCTGCT GCTGCTACCC CTCCCAAGCT CATGGTTTGC CCACGGGCAC 
CCACTGTACA CACGCCTGCC CCCCAGCGCC CTGCAAGTTC TGTCGGCCCA GGGGACTCAG 
GCGTTGCAGG CAGCCCAGAG GAGCGCCCAG TGGGCAATAA ACCGAGTGGC GATGGAGATC 
CAGCACAGAT CGCACGAGTG CCGAGGATCT GGGCGCCCCA GGCCTCAAGC TCTCCTCCAG 
GACCCACCTG AGCCAGGGCC GTGCGGCGAG AGGCGTCCGA GCACTGCCAA TGTGACGCGG 
GCCCACGGCC GCATCGTGGG GGGCAGCGCG GCGCCGCCCG GGGCCTGGCC CTGGCTGGTG 
AGGCTGCAGC TCGGCGGGCA GCCTCTGTGC GGCGGCGTCC TGGTAGCGGC CTCCTGGGTG 
CTCACGGCAG CGCACTGCTT TGTAGGCGCC CCGAATGAGC TTCTGTGGAC TGTGACGCTG 
GCAGAGGGGT CCCGGGGGGA GCAAGCGGAG GAGGTGCCAG TGAACCGCAT CCTGCCCCAC 
CCCAAGTTTG ACCCGCGGAC CTTCCACAAC GACCTGGCCC TGGTGCAGCT GTGGACGCCG 
GTGAGCCCGG GGGGATCGGC GCGCCCCGTG TGCCTGCCCC AGGAGCCCCA GGAGCCCCCT 
GCCGGAACCG CCTGCGCCAT CGCGGGCTGG GGCGCCCTCT TCGAAGACGG GCCTGAGGCT 
GAAGCAGTGA GAGAGGCCCG TGTTCCCCTG CTCAGCACCG ACACCTGCCG AAGAGCCCTG 
GGGCCCGGGC TGCGCCCCAG CACCATGCTC TGCGCCGGGT ACCTGGCGGG GGGCGTTGAC 
TCGTGCCAGG GTGACTCGGG AGGCCCCCTG ACCTGTTCTG AGCCTGGCCC CCGCCCTAGA 
GAGGTCCTGT TCGGAGTCAC CTCCTGGGGG GACGGCTGCG GGGAGCCAGG GAAGCCCGGG 
GTCTACACCC GCGTGGCAGT GTTCAAGGAC TGGCTCCAGG AGCAGATGAG CGCCTCCTCC 
AGCCGCGAGC CCAGCTGCAG GGAGCTTCTG GCCTGGGACC CCCCCCAGGA GCTGCAGGCA 
GACGCCGCCC GGCTCTGCGC CTTCTATGCC CGCCTGTGCC CGGGGTCCCA GGGCGCCTGT 
GCGCGCCTGG CGCACCAGCA GTGCCTGCAG CGCCGGCGGC GATGCGAGCT GCGCTCGCTG 
GCGCACACGC TGCTGGGCCT GCTGCGGAAC GCGCAGGAGC TGCTCGGGCC TCGTCCGGGA 
CTGCGGCGCC TGGCCCCCGC CCTGGCTCTC CCCGCTCCAG CGCTCAGGGA GTCTCCTCTG 
CACCCCGCCC GGGAGCTGCG GCTTCACTCA GGATCGCGGG CTGCAGGCAC TCGGTTCCCG 
AAGCGGAGGC CGGAGCCGCG CGGAGAAGCC AACGGCTGCC CTGGGCTGGA GCCCCTGCGA 
CAGAAGTTGG CTGCCCTGCA GGGGGCCCAT GCCTGGATCC TGCAGGTCCC CTCGGAGCAC 
CTGGCCATGA ACTTTCATGA GGTCCTGGCA GATCTGGGCT CCAAGACACT GACCGGGCTT 
TTCAGAGCCT GGGTGCGGGC AGGCTTGGGG GGCCGGCATG TGGCCTTCAG CGGCCTGGTG 
GGCCTGGAGC CGGCCACACT GGCTCGCAGC CTCCCCCGGC TGCTGGTGCA GGCCCTGCAG 
GCCTTCCGCG TGGCTGCCCT GGCAGAAGGG GAGCCCGAGG GACCCTGGAT GGATGTAGGG 
CAGGGGCCCG GGCTGGAGAG GAAGGGGCAC CACCCACTCA ACCCTCAGGT ACCCCCCGCC 
AGGCAACCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PRSS56 ( NM_001369848.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001356777.1 Homo sapiens serine protease 56 (PRSS56), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu108038
Clone ID Related Accession (Same CDS sequence)	NM_001369848.1
Accession Version	NM_001369848.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1815bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	serine protease 56 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC092165.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.

ATGCTGCTGG CTGTGCTGCT GCTGCTACCC CTCCCAAGCT CATGGTTTGC CCACGGGCAC 
CCACTGTACA CACGCCTGCC CCCCAGCGCC CTGCAAGTTC TGTCGGCCCA GGGGACTCAG 
GCGTTGCAGG CAGCCCAGAG GAGCGCCCAG TGGGCAATAA ACCGAGTGGC GATGGAGATC 
CAGCACAGAT CGCACGAGTG CCGAGGATCT GGGCGCCCCA GGCCTCAAGC TCTCCTCCAG 
GACCCACCTG AGCCAGGGCC GTGCGGCGAG AGGCGTCCGA GCACTGCCAA TGTGACGCGG 
GCCCACGGCC GCATCGTGGG GGGCAGCGCG GCGCCGCCCG GGGCCTGGCC CTGGCTGGTG 
AGGCTGCAGC TCGGCGGGCA GCCTCTGTGC GGCGGCGTCC TGGTAGCGGC CTCCTGGGTG 
CTCACGGCAG CGCACTGCTT TGTAGGCGCC CCGAATGAGC TTCTGTGGAC TGTGACGCTG 
GCAGAGGGGT CCCGGGGGGA GCAAGCGGAG GAGGTGCCAG TGAACCGCAT CCTGCCCCAC 
CCCAAGTTTG ACCCGCGGAC CTTCCACAAC GACCTGGCCC TGGTGCAGCT GTGGACGCCG 
GTGAGCCCGG GGGGATCGGC GCGCCCCGTG TGCCTGCCCC AGGAGCCCCA GGAGCCCCCT 
GCCGGAACCG CCTGCGCCAT CGCGGGCTGG GGCGCCCTCT TCGAAGACGG GCCTGAGGCT 
GAAGCAGTGA GAGAGGCCCG TGTTCCCCTG CTCAGCACCG ACACCTGCCG AAGAGCCCTG 
GGGCCCGGGC TGCGCCCCAG CACCATGCTC TGCGCCGGGT ACCTGGCGGG GGGCGTTGAC 
TCGTGCCAGG GTGACTCGGG AGGCCCCCTG ACCTGTTCTG AGCCTGGCCC CCGCCCTAGA 
GAGGTCCTGT TCGGAGTCAC CTCCTGGGGG GACGGCTGCG GGGAGCCAGG GAAGCCCGGG 
GTCTACACCC GCGTGGCAGT GTTCAAGGAC TGGCTCCAGG AGCAGATGAG CGCAGCCTCC 
TCCAGCCGCG AGCCCAGCTG CAGGGAGCTT CTGGCCTGGG ACCCCCCCCA GGAGCTGCAG 
GCAGACGCCG CCCGGCTCTG CGCCTTCTAT GCCCGCCTGT GCCCGGGGTC CCAGGGCGCC 
TGTGCGCGCC TGGCGCACCA GCAGTGCCTG CAGCGCCGGC GGCGATGCGA GCTGCGCTCG 
CTGGCGCACA CGCTGCTGGG CCTGCTGCGG AACGCGCAGG AGCTGCTCGG GCCTCGTCCG 
GGACTGCGGC GCCTGGCCCC CGCCCTGGCT CTCCCCGCTC CAGCGCTCAG GGAGTCTCCT 
CTGCACCCCG CCCGGGAGCT GCGGCTTCAC TCAGGATCGC GGGCTGCAGG CACTCGGTTC 
CCGAAGCGGA GGCCGGAGCC GCGCGGAGAA GCCAACGGCT GCCCTGGGCT GGAGCCCCTG 
CGACAGAAGT TGGCTGCCCT GCAGGGGGCC CATGCCTGGA TCCTGCAGGT CCCCTCGGAG 
CACCTGGCCA TGAACTTTCA TGAGGTCCTG GCAGATCTGG GCTCCAAGAC ACTGACCGGG 
CTTTTCAGAG CCTGGGTGCG GGCAGGCTTG GGGGGCCGGC ATGTGGCCTT CAGCGGCCTG 
GTGGGCCTGG AGCCGGCCAC ACTGGCTCGC AGCCTCCCCC GGCTGCTGGT GCAGGCCCTG 
CAGGCCTTCC GCGTGGCTGC CCTGGCAGAA GGGGAGCCCG AGGGACCCTG GATGGATGTA 
GGGCAGGGGC CCGGGCTGGA GAGGAAGGGG CACCACCCAC TCAACCCTCA GGTACCCCCC 
GCCAGGCAAC CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001356777.1
CDS	137..1951
Translation	MLLAVLLLLPLPSSWFAHGHPLYTRLPPSALQVLSAQGTQALQAAQRSAQWAINRVAMEIQHRSHECRGSGRPRPQALLQDPPEPGPCGERRPSTANVTRAHGRIVGGSAAPPGAWPWLVRLQLGGQPLCGGVLVAASWVLTAAHCFVGAPNELLWTVTLAEGSRGEQAEEVPVNRILPHPKFDPRTFHNDLALVQLWTPVSPGGSARPVCLPQEPQEPPAGTACAIAGWGALFEDGPEAEAVREARVPLLSTDTCRRALGPGLRPSTMLCAGYLAGGVDSCQGDSGGPLTCSEPGPRPREVLFGVTSWGDGCGEPGKPGVYTRVAVFKDWLQEQMSAASSSREPSCRELLAWDPPQELQADAARLCAFYARLCPGSQGACARLAHQQCLQRRRRCELRSLAHTLLGLLRNAQELLGPRPGLRRLAPALALPAPALRESPLHPARELRLHSGSRAAGTRFPKRRPEPRGEANGCPGLEPLRQKLAALQGAHAWILQVPSEHLAMNFHEVLADLGSKTLTGLFRAWVRAGLGGRHVAFSGLVGLEPATLARSLPRLLVQALQAFRVAALAEGEPEGPWMDVGQGPGLERKGHHPLNPQVPPARQP

Target ORF information:

RefSeq Version	NM_001369848.1
Organism	Homo sapiens(human)
Definition	Homo sapiens serine protease 56 (PRSS56), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001369848.1

ORF Insert Sequence:

ATGCTGCTGG CTGTGCTGCT GCTGCTACCC CTCCCAAGCT CATGGTTTGC CCACGGGCAC 
CCACTGTACA CACGCCTGCC CCCCAGCGCC CTGCAAGTTC TGTCGGCCCA GGGGACTCAG 
GCGTTGCAGG CAGCCCAGAG GAGCGCCCAG TGGGCAATAA ACCGAGTGGC GATGGAGATC 
CAGCACAGAT CGCACGAGTG CCGAGGATCT GGGCGCCCCA GGCCTCAAGC TCTCCTCCAG 
GACCCACCTG AGCCAGGGCC GTGCGGCGAG AGGCGTCCGA GCACTGCCAA TGTGACGCGG 
GCCCACGGCC GCATCGTGGG GGGCAGCGCG GCGCCGCCCG GGGCCTGGCC CTGGCTGGTG 
AGGCTGCAGC TCGGCGGGCA GCCTCTGTGC GGCGGCGTCC TGGTAGCGGC CTCCTGGGTG 
CTCACGGCAG CGCACTGCTT TGTAGGCGCC CCGAATGAGC TTCTGTGGAC TGTGACGCTG 
GCAGAGGGGT CCCGGGGGGA GCAAGCGGAG GAGGTGCCAG TGAACCGCAT CCTGCCCCAC 
CCCAAGTTTG ACCCGCGGAC CTTCCACAAC GACCTGGCCC TGGTGCAGCT GTGGACGCCG 
GTGAGCCCGG GGGGATCGGC GCGCCCCGTG TGCCTGCCCC AGGAGCCCCA GGAGCCCCCT 
GCCGGAACCG CCTGCGCCAT CGCGGGCTGG GGCGCCCTCT TCGAAGACGG GCCTGAGGCT 
GAAGCAGTGA GAGAGGCCCG TGTTCCCCTG CTCAGCACCG ACACCTGCCG AAGAGCCCTG 
GGGCCCGGGC TGCGCCCCAG CACCATGCTC TGCGCCGGGT ACCTGGCGGG GGGCGTTGAC 
TCGTGCCAGG GTGACTCGGG AGGCCCCCTG ACCTGTTCTG AGCCTGGCCC CCGCCCTAGA 
GAGGTCCTGT TCGGAGTCAC CTCCTGGGGG GACGGCTGCG GGGAGCCAGG GAAGCCCGGG 
GTCTACACCC GCGTGGCAGT GTTCAAGGAC TGGCTCCAGG AGCAGATGAG CGCAGCCTCC 
TCCAGCCGCG AGCCCAGCTG CAGGGAGCTT CTGGCCTGGG ACCCCCCCCA GGAGCTGCAG 
GCAGACGCCG CCCGGCTCTG CGCCTTCTAT GCCCGCCTGT GCCCGGGGTC CCAGGGCGCC 
TGTGCGCGCC TGGCGCACCA GCAGTGCCTG CAGCGCCGGC GGCGATGCGA GCTGCGCTCG 
CTGGCGCACA CGCTGCTGGG CCTGCTGCGG AACGCGCAGG AGCTGCTCGG GCCTCGTCCG 
GGACTGCGGC GCCTGGCCCC CGCCCTGGCT CTCCCCGCTC CAGCGCTCAG GGAGTCTCCT 
CTGCACCCCG CCCGGGAGCT GCGGCTTCAC TCAGGATCGC GGGCTGCAGG CACTCGGTTC 
CCGAAGCGGA GGCCGGAGCC GCGCGGAGAA GCCAACGGCT GCCCTGGGCT GGAGCCCCTG 
CGACAGAAGT TGGCTGCCCT GCAGGGGGCC CATGCCTGGA TCCTGCAGGT CCCCTCGGAG 
CACCTGGCCA TGAACTTTCA TGAGGTCCTG GCAGATCTGG GCTCCAAGAC ACTGACCGGG 
CTTTTCAGAG CCTGGGTGCG GGCAGGCTTG GGGGGCCGGC ATGTGGCCTT CAGCGGCCTG 
GTGGGCCTGG AGCCGGCCAC ACTGGCTCGC AGCCTCCCCC GGCTGCTGGT GCAGGCCCTG 
CAGGCCTTCC GCGTGGCTGC CCTGGCAGAA GGGGAGCCCG AGGGACCCTG GATGGATGTA 
GGGCAGGGGC CCGGGCTGGA GAGGAAGGGG CACCACCCAC TCAACCCTCA GGTACCCCCC 
GCCAGGCAAC CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Posterior microphthalmia and nanophthalmia in Tunisia caused by a founder c.1059_1066insC mutation of the PRSS56 gene.
Gene528(2)288-94(2013 Oct)
Said MB,Chouch?ne E,Salem SB,Daoud K,Largueche L,Bouassida W,Benzina Z,Ayadi H,S?derkvist P,Matri L,Hmani-Aifa M

Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia.
Nature genetics45(3)314-8(2013 Mar)
Verhoeven VJ,Hysi PG,Wojciechowski R,Fan Q,Guggenheim JA,H?hn R,MacGregor S,Hewitt AW,Nag A,Cheng CY,Yonova-Doing E,Zhou X,Ikram MK,Buitendijk GH,McMahon G,Kemp JP,Pourcain BS,Simpson CL,M?kel? KM,Lehtim?ki T,K?h?nen M,Paterson AD,Hosseini SM,Wong HS,Xu L,Jonas JB,P?rssinen O,Wedenoja J,Yip SP,Ho DW,Pang CP,Chen LJ,Burdon KP,Craig JE,Klein BE,Klein R,Haller T,Metspalu A,Khor CC,Tai ES,Aung T,Vithana E,Tay WT,Barathi VA,,Chen P,Li R,Liao J,Zheng Y,Ong RT,D?ring A,,Evans DM,Timpson NJ,Verkerk AJ,Meitinger T,Raitakari O,Hawthorne F,Spector TD,Karssen LC,Pirastu M,Murgia F,Ang W,,Mishra A,Montgomery GW,Pennell CE,Cumberland PM,Cotlarciuc I,Mitchell P,Wang JJ,Schache M,Janmahasatian S,Janmahasathian S,Igo RP Jr,Lass JH,Chew E,Iyengar SK,,Gorgels TG,Rudan I,Hayward C,Wright AF,Polasek O,Vatavuk Z,Wilson JF,Fleck B,Zeller T,Mirshahi A,M?ller C,Uitterlinden AG,Rivadeneira F,Vingerling JR,Hofman A,Oostra BA,Amin N,Bergen AA,Teo YY,Rahi JS,Vitart V,Williams C,Baird PN,Wong TY,Oexle K,Pfeiffer N,Mackey DA,Young TL,van Duijn CM,Saw SM,Bailey-Wilson JE,Stambolian D,Klaver CC,Hammond CJ

Biometric and molecular characterization of clinically diagnosed posterior microphthalmos.
American journal of ophthalmology155(2)361-372.e7(2013 Feb)
Nowilaty SR,Khan AO,Aldahmesh MA,Tabbara KF,Al-Amri A,Alkuraya FS

Evaluation of PRSS56 in Chinese subjects with high hyperopia or primary angle-closure glaucoma.
Molecular vision192217-26(2013)
Jiang D,Yang Z,Li S,Xiao X,Jia X,Wang P,Guo X,Liu X,Zhang Q

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PRSS56 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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