FBXW4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FBXW4
Entrez Gene ID	6468
Full Name	F-box and WD repeat domain containing 4
Synonyms	DAC,FBW4,FBWD4,SHFM3,SHSF3
General protein information	Preferred Names F-box and WD repeat domain containing 4 Names F-box/WD repeat-containing protein 4 F-box and WD-40 domain protein 4 F-box and WD-40 domain-containing protein 4 F-box/WD repeat protein 4 dactylin
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10q24.32
Summary	This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22. [provided by RefSeq, Jul 2008].
Disorder MIM:	608071

mRNA and Protein(s)

mRNA	Protein	Name
XM_005270053.2	XP_005270110.2	F-box/WD repeat-containing protein 4 isoform X1
NM_022039.4	NP_071322.2	F-box/WD repeat-containing protein 4 isoform 1
NM_001323541.1	NP_001310470.1	F-box/WD repeat-containing protein 4 isoform 2
XM_005270053.3	XP_005270110.2	F-box/WD repeat-containing protein 4 isoform X1
NM_022039.3	NP_071322.1	F-box/WD repeat-containing protein 4 isoform 1
XM_017016570.2	XP_016872059.1	F-box/WD repeat-containing protein 4 isoform X2
XM_017016570.1	XP_016872059.1	F-box/WD repeat-containing protein 4 isoform X2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	FBXW4	XP_507994.4
Gallus gallus (chicken)	FBXW4	XP_001233793.1
	FBXW4	XP_001110869.2
Xenopus tropicalis (tropical clawed frog)	fbxw4	XP_002936816.1
Canis lupus familiaris (dog)	FBXW4	XP_543981.3
Bos taurus (cattle)	FBXW4	NP_001095455.1
Rattus norvegicus (Norway rat)	Fbxw4	NP_001101070.1
Homo sapiens (human)	FBXW4	NP_071322.1
Mus musculus (house mouse)	Fbxw4	NP_038935.1
Danio rerio (zebrafish)	fbxw4	NP_571596.1

Gene Ontology
Bibliography

Related articles in PubMed

A High-Density Map for Navigating the Human Polycomb Complexome.
Hauri S, Comoglio F, Seimiya M, Gerstung M, Glatter T, Hansen K, Aebersold R, Paro R, Gstaiger M, Beisel C
Cell reports17(2)583-595(2016 10)

The novel ubiquitin ligase complex, SCF(Fbxw4), interacts with the COP9 signalosome in an F-box dependent manner, is mutated, lost and under-expressed in human cancers.
Lockwood WW, Chandel SK, Stewart GL, Erdjument-Bromage H, Beverly LJ
PloS one8(5)e63610(2013)

Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair.
D'Angiolella V, Donato V, Forrester FM, Jeong YT, Pellacani C, Kudo Y, Saraf A, Florens L, Washburn MP, Pagano M
Cell149(5)1023-34(2012 May)

Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system.
Ebstein F, Lange N, Urban S, Seifert U, Kr?ger E, Kloetzel PM
The international journal of biochemistry & cell biology41(5)1205-15(2009 May)

Frequency of genomic rearrangements involving the SHFM3 locus at chromosome 10q24 in syndromic and non-syndromic split-hand/foot malformation.
Everman DB, Morgan CT, Lyle R, Laughridge ME, Bamshad MJ, Clarkson KB, Colby R, Gurrieri F, Innes AM, Roberson J, Schrander-Stumpel C, van Bokhoven H, Antonarakis SE, Schwartz CE
American journal of medical genetics. Part A140(13)1375-83(2006 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

biochemical characterization of the novel F-box and WD40 containing protein, FBXW4
Title: The novel ubiquitin ligase complex, SCF(Fbxw4), interacts with the COP9 signalosome in an F-box dependent manner, is mutated, lost and under-expressed in human cancers.

Genomic rearrangements involving the SHFM3 locus at chromosome 10q24 is associated with syndromic and non-syndromic split-hand/foot malformation
Title: Frequency of genomic rearrangements involving the SHFM3 locus at chromosome 10q24 in syndromic and non-syndromic split-hand/foot malformation.

results indicate that genomic rearrangement of SHFM3 is rare among non-syndromic SHFM patients and emphasize the importance of screening for genomic rearrangements even in sporadic cases of SHFM
Title: Genomic rearrangement at 10q24 in non-syndromic split-hand/split-foot malformation.

a complex rearrangement associated with a approximately 0.5 Mb tandem duplication ion containing a disrupted extra copy of the DACTYLIN gene and the entire LBX1 and beta-TRCP genes.
Title: A genomic rearrangement resulting in a tandem duplication is associated with split hand-split foot malformation 3 (SHFM3) at 10q24.

The following FBXW4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FBXW4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18321	NM_022039.3 Latest version!	Homo sapiens F-box and WD repeat domain containing 4 (FBXW4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu101978	NM_001323541.1 Latest version!	Homo sapiens F-box and WD repeat domain containing 4 (FBXW4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu107380	NM_022039.4 Latest version!	Homo sapiens F-box and WD repeat domain containing 4 (FBXW4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
OHu60490	XM_005270053.3 Latest version!	Homo sapiens F-box and WD repeat domain containing 4 (FBXW4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
OHu91593	XM_017016570.2 Latest version!	Homo sapiens F-box and WD repeat domain containing 4 (FBXW4), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
View Old Accession Versions >>
OHu60490	XM_005270053.2	Homo sapiens F-box and WD repeat domain containing 4 (FBXW4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
OHu91593	XM_017016570.1	Homo sapiens F-box and WD repeat domain containing 4 (FBXW4), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FBXW4 ( NM_022039.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_071322.1 Homo sapiens F-box and WD repeat domain containing 4 (FBXW4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18321
Clone ID Related Accession (Same CDS sequence)	NM_022039.3
Accession Version	NM_022039.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1239bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	F-box/WD repeat-containing protein 4 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF281859.1 and BC063415.1. This sequence is a reference standard in the RefSeqGene project. On May 6, 2005 this sequence version replaced NM_022039.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC063415.1, SRR1163655.273283.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCGG CGGCCGGGGA GGAGGAGGAG GAGGAGGAGG CGGCTCGGGA GTCGGCTGCC 
CGCCCGGCCG CGGGGCCTGC GCTCTGGCGC CTGCCGGAGG AGCTGCTGCT GCTCATCTGC 
TCCTACCTGG ACATGCGGGC CCTCGGCCGC CTGGCCCAGG TGTGCCGCTG GCTGCGGCGC 
TTCACCAGCT GCGATCTGCT CTGGCGCCGG ATAGCCCGGG CCTCGCTCAA CTCCGGCTTC 
ACGCGGCTCG GCACCGACCT GATGACCAGT GTCCCAGTGA AGGAACGAGT GAAGGTGTCT 
CAGAACTGGA GACTGGGGCG CTGCCGAGAG GGGATTCTGC TGAAGTGGAG ATGCAGTCAG 
ATGCCCTGGA TGCAGCTAGA GGATGATTCT CTGTACATAT CCCAGGCTAA TTTCATCCTG 
GCCTACCAGT TCCGTCCAGA TGGTGCCAGC TTGAATCGTC GGCCTCTGGG AGTCTTTGCT 
GGGCATGATG AGGACGTTTG CCACTTTGTG CTGGCCAACT CGCATATTGT TAGTGCAGGA 
GGGGATGGGA AGATTGGCAT TCATAAGATT CACAGCACCT TCACTGTCAA GTACTCGGCT 
CATGAACAGG AGGTGAACTG TGTGGATTGC AAAGGGGGCA TCATTGTGAG TGGCTCCAGG 
GACAGGACGG CCAAGGTGTG GCCTTTGGCC TCAGGCCGGC TGGGGCAGTG CTTACACACC 
ATCCAGACTG AAGACCGAGT CTGGTCCATT GCTATCAGCC CATTACTCAG CTCTTTTGTG 
ACAGGGACGG CTTGTTGCGG GCACTTCTCA CCCCTGAGAA TCTGGGACCT CAACAGTGGG 
CAGCTGATGA CACACTTGGG CAGTGACTTT CCCCCAGGGG CTGGGGTGCT GGATGTCATG 
TATGAGTCCC CTTTCACACT GCTGTCCTGT GGCTATGACA CCTATGTTCG CTACTGGGAC 
CTCCGCACCA GCGTCCGGAA ATGTGTCATG GAGTGGGAGG AGCCCCACGA CAGCACCCTG 
TACTGCCTGC AGACAGATGG CAACCACCTG CTGGCCACAG GTTCCTCCTA CTACGGTGTT 
GTACGGCTGT GGGACCGGCG TCAAAGGGCC TGCCTGCACG CCTTCCCGCT GACGTCGACT 
CCCCTCAGCA GCCCTGTGTA CTGCCTGCGT CTCACCACCA AGCATCTCTA TGCTGCCCTG 
TCTTACAACC TCCACGTCCT GGATTTTCAA AACCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071322.1
CDS	347..1585
Translation	MAAAAGEEEEEEEAARESAARPAAGPALWRLPEELLLLICSYLDMRALGRLAQVCRWLRRFTSCDLLWRRIARASLNSGFTRLGTDLMTSVPVKERVKVSQNWRLGRCREGILLKWRCSQMPWMQLEDDSLYISQANFILAYQFRPDGASLNRRPLGVFAGHDEDVCHFVLANSHIVSAGGDGKIGIHKIHSTFTVKYSAHEQEVNCVDCKGGIIVSGSRDRTAKVWPLASGRLGQCLHTIQTEDRVWSIAISPLLSSFVTGTACCGHFSPLRIWDLNSGQLMTHLGSDFPPGAGVLDVMYESPFTLLSCGYDTYVRYWDLRTSVRKCVMEWEEPHDSTLYCLQTDGNHLLATGSSYYGVVRLWDRRQRACLHAFPLTSTPLSSPVYCLRLTTKHLYAALSYNLHVLDFQNP

Target ORF information:

RefSeq Version	NM_022039.3
Organism	Homo sapiens(human)
Definition	Homo sapiens F-box and WD repeat domain containing 4 (FBXW4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022039.3

ORF Insert Sequence:

ATGGCGGCGG CGGCCGGGGA GGAGGAGGAG GAGGAGGAGG CGGCTCGGGA GTCGGCTGCC 
CGCCCGGCCG CGGGGCCTGC GCTCTGGCGC CTGCCGGAGG AGCTGCTGCT GCTCATCTGC 
TCCTACCTGG ACATGCGGGC CCTCGGCCGC CTGGCCCAGG TGTGCCGCTG GCTGCGGCGC 
TTCACCAGCT GCGATCTGCT CTGGCGCCGG ATAGCCCGGG CCTCGCTCAA CTCCGGCTTC 
ACGCGGCTCG GCACCGACCT GATGACCAGT GTCCCAGTGA AGGAACGAGT GAAGGTGTCT 
CAGAACTGGA GACTGGGGCG CTGCCGAGAG GGGATTCTGC TGAAGTGGAG ATGCAGTCAG 
ATGCCCTGGA TGCAGCTAGA GGATGATTCT CTGTACATAT CCCAGGCTAA TTTCATCCTG 
GCCTACCAGT TCCGTCCAGA TGGTGCCAGC TTGAATCGTC GGCCTCTGGG AGTCTTTGCT 
GGGCATGATG AGGACGTTTG CCACTTTGTG CTGGCCAACT CGCATATTGT TAGTGCAGGA 
GGGGATGGGA AGATTGGCAT TCATAAGATT CACAGCACCT TCACTGTCAA GTACTCGGCT 
CATGAACAGG AGGTGAACTG TGTGGATTGC AAAGGGGGCA TCATTGTGAG TGGCTCCAGG 
GACAGGACGG CCAAGGTGTG GCCTTTGGCC TCAGGCCGGC TGGGGCAGTG CTTACACACC 
ATCCAGACTG AAGACCGAGT CTGGTCCATT GCTATCAGCC CATTACTCAG CTCTTTTGTG 
ACAGGGACGG CTTGTTGCGG GCACTTCTCA CCCCTGAGAA TCTGGGACCT CAACAGTGGG 
CAGCTGATGA CACACTTGGG CAGTGACTTT CCCCCAGGGG CTGGGGTGCT GGATGTCATG 
TATGAGTCCC CTTTCACACT GCTGTCCTGT GGCTATGACA CCTATGTTCG CTACTGGGAC 
CTCCGCACCA GCGTCCGGAA ATGTGTCATG GAGTGGGAGG AGCCCCACGA CAGCACCCTG 
TACTGCCTGC AGACAGATGG CAACCACCTG CTGGCCACAG GTTCCTCCTA CTACGGTGTT 
GTACGGCTGT GGGACCGGCG TCAAAGGGCC TGCCTGCACG CCTTCCCGCT GACGTCGACT 
CCCCTCAGCA GCCCTGTGTA CTGCCTGCGT CTCACCACCA AGCATCTCTA TGCTGCCCTG 
TCTTACAACC TCCACGTCCT GGATTTTCAA AACCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FBXW4 ( NM_001323541.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001310470.1 Homo sapiens F-box and WD repeat domain containing 4 (FBXW4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu101978
Clone ID Related Accession (Same CDS sequence)	NM_001323541.1
Accession Version	NM_001323541.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 978bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-05
Organism	Homo sapiens(human)
Product	F-box/WD repeat-containing protein 4 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC010789.9, AL627144.7 and AL627424.8. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189661.126873.1, SRR1163658.135322.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACCAGTG TCCCAGTGAA GGAACGAGTG AAGGTGTCTC AGAACTGGAG ACTGGGGCGC 
TGCCGAGAGG GGATTCTGCT GAAGTGGAGA TGCAGTCAGA TGCCCTGGAT GCAGCTAGAG 
GATGATTCTC TGTACATATC CCAGGCTAAT TTCATCCTGG CCTACCAGTT CCGTCCAGAT 
GGTGCCAGCT TGAATCGTCG GCCTCTGGGA GTCTTTGCTG GGCATGATGA GGACGTTTGC 
CACTTTGTGC TGGCCAACTC GCATATTGTT AGTGCAGGAG GGGATGGGAA GATTGGCATT 
CATAAGATTC ACAGCACCTT CACTGTCAAG TACTCGGCTC ATGAACAGGA GGTGAACTGT 
GTGGATTGCA AAGGGGGCAT CATTGTGAGT GGCTCCAGGG ACAGGACGGC CAAGGTGTGG 
CCTTTGGCCT CAGGCCGGCT GGGGCAGTGC TTACACACCA TCCAGACTGA AGACCGAGTC 
TGGTCCATTG CTATCAGCCC ATTACTCAGC TCTTTTGTGA CAGGGACGGC TTGTTGCGGG 
CACTTCTCAC CCCTGAGAAT CTGGGACCTC AACAGTGGGC AGCTGATGAC ACACTTGGGC 
AGTGACTTTC CCCCAGGGGC TGGGGTGCTG GATGTCATGT ATGAGTCCCC TTTCACACTG 
CTGTCCTGTG GCTATGACAC CTATGTTCGC TACTGGGACC TCCGCACCAG CGTCCGGAAA 
TGTGTCATGG AGTGGGAGGA GCCCCACGAC AGCACCCTGT ACTGCCTGCA GACAGATGGC 
AACCACCTGC TGGCCACAGG TTCCTCCTAC TACGGTGTTG TACGGCTGTG GGACCGGCGT 
CAAAGGGCCT GCCTGCACGC CTTCCCGCTG ACGTCGACTC CCCTCAGCAG CCCTGTGTAC 
TGCCTGCGTC TCACCACCAA GCATCTCTAT GCTGCCCTGT CTTACAACCT CCACGTCCTG 
GATTTTCAAA ACCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001310470.1
CDS	58..1035
Translation	MTSVPVKERVKVSQNWRLGRCREGILLKWRCSQMPWMQLEDDSLYISQANFILAYQFRPDGASLNRRPLGVFAGHDEDVCHFVLANSHIVSAGGDGKIGIHKIHSTFTVKYSAHEQEVNCVDCKGGIIVSGSRDRTAKVWPLASGRLGQCLHTIQTEDRVWSIAISPLLSSFVTGTACCGHFSPLRIWDLNSGQLMTHLGSDFPPGAGVLDVMYESPFTLLSCGYDTYVRYWDLRTSVRKCVMEWEEPHDSTLYCLQTDGNHLLATGSSYYGVVRLWDRRQRACLHAFPLTSTPLSSPVYCLRLTTKHLYAALSYNLHVLDFQNP

Target ORF information:

RefSeq Version	NM_001323541.1
Organism	Homo sapiens(human)
Definition	Homo sapiens F-box and WD repeat domain containing 4 (FBXW4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001323541.1

ORF Insert Sequence:

ATGACCAGTG TCCCAGTGAA GGAACGAGTG AAGGTGTCTC AGAACTGGAG ACTGGGGCGC 
TGCCGAGAGG GGATTCTGCT GAAGTGGAGA TGCAGTCAGA TGCCCTGGAT GCAGCTAGAG 
GATGATTCTC TGTACATATC CCAGGCTAAT TTCATCCTGG CCTACCAGTT CCGTCCAGAT 
GGTGCCAGCT TGAATCGTCG GCCTCTGGGA GTCTTTGCTG GGCATGATGA GGACGTTTGC 
CACTTTGTGC TGGCCAACTC GCATATTGTT AGTGCAGGAG GGGATGGGAA GATTGGCATT 
CATAAGATTC ACAGCACCTT CACTGTCAAG TACTCGGCTC ATGAACAGGA GGTGAACTGT 
GTGGATTGCA AAGGGGGCAT CATTGTGAGT GGCTCCAGGG ACAGGACGGC CAAGGTGTGG 
CCTTTGGCCT CAGGCCGGCT GGGGCAGTGC TTACACACCA TCCAGACTGA AGACCGAGTC 
TGGTCCATTG CTATCAGCCC ATTACTCAGC TCTTTTGTGA CAGGGACGGC TTGTTGCGGG 
CACTTCTCAC CCCTGAGAAT CTGGGACCTC AACAGTGGGC AGCTGATGAC ACACTTGGGC 
AGTGACTTTC CCCCAGGGGC TGGGGTGCTG GATGTCATGT ATGAGTCCCC TTTCACACTG 
CTGTCCTGTG GCTATGACAC CTATGTTCGC TACTGGGACC TCCGCACCAG CGTCCGGAAA 
TGTGTCATGG AGTGGGAGGA GCCCCACGAC AGCACCCTGT ACTGCCTGCA GACAGATGGC 
AACCACCTGC TGGCCACAGG TTCCTCCTAC TACGGTGTTG TACGGCTGTG GGACCGGCGT 
CAAAGGGCCT GCCTGCACGC CTTCCCGCTG ACGTCGACTC CCCTCAGCAG CCCTGTGTAC 
TGCCTGCGTC TCACCACCAA GCATCTCTAT GCTGCCCTGT CTTACAACCT CCACGTCCTG 
GATTTTCAAA ACCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FBXW4 ( NM_022039.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_071322.2 Homo sapiens F-box and WD repeat domain containing 4 (FBXW4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu107380
Clone ID Related Accession (Same CDS sequence)	NM_022039.4
Accession Version	NM_022039.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1704bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	F-box/WD repeat-containing protein 4 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF281859.1. This sequence is a reference standard in the RefSeqGene project. On Dec 1, 2018 this sequence version replaced NM_022039.3. CCDS Note: The coding region has been updated to extend the N-terminus and this extension is supported by conservation data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF281859.1, SRR1163655.35849.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000331272.9/ ENSP00000359149.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGCAGCC AGGGCCGCTC GGGGCCCCCC GGGAACGGCG GGCCCGGCGA GGGCGAGGGC 
GGAGAGGCGA GGAAGCTGCA GGAAGGGAGG GTGGCGAGGG GGAAGCGAAG GAAGGGGAAG 
GGGAAGGGAA AAGCGAGAGC GGGGCAAGGC GGAAGAGGAA GCGGGGCGGA AGGGAAGCCC 
GGGCCGCAGA CGGCGAAGGA GGCAGCCGGG CCGGGGGCTG ACGCGGGAGC GAGGGCATGC 
CCAAGGGAGG AAGCAGAGGG AGGCAGAAGC GTGGAGGAAG GGGCGAGAGG CATCGTCAAG 
GGAGTCGAGG GGAGCGCAGG GGCCGGGAAG GAGGCACAAG GAAGAGAGTA TGGGAAGAAG 
GAGGAATGGA GGGTCAGGGC TAGGCGGCGG GAGGGCGCCA GGCCGGGAAG AGCACAGGGA 
CGAGGGGGTC AGGCTTGGGC CGACATCGCG GGGACAGGGG TGGCCATGGC GGCGGCGGCC 
GGGGAGGAGG AGGAGGAGGA GGAGGCGGCT CGGGAGTCGG CTGCCCGCCC GGCCGCGGGG 
CCTGCGCTCT GGCGCCTGCC GGAGGAGCTG CTGCTGCTCA TCTGCTCCTA CCTGGACATG 
CGGGCCCTCG GCCGCCTGGC CCAGGTGTGC CGCTGGCTGC GGCGCTTCAC CAGCTGCGAT 
CTGCTCTGGC GCCGGATAGC CCGGGCCTCG CTCAACTCCG GCTTCACGCG GCTCGGCACC 
GACCTGATGA CCAGTGTCCC AGTGAAGGAA CGAGTGAAGG TGTCTCAGAA CTGGAGACTG 
GGGCGCTGCC GAGAGGGGAT TCTGCTGAAG TGGAGATGCA GTCAGATGCC CTGGATGCAG 
CTAGAGGATG ATTCTCTGTA CATATCCCAG GCTAATTTCA TCCTGGCCTA CCAGTTCCGT 
CCAGATGGTG CCAGCTTGAA TCGTCGGCCT CTGGGAGTCT TTGCTGGGCA TGATGAGGAC 
GTTTGCCACT TTGTGCTGGC CAACTCGCAT ATTGTTAGTG CAGGAGGGGA TGGGAAGATT 
GGCATTCATA AGATTCACAG CACCTTCACT GTCAAGTACT CGGCTCATGA ACAGGAGGTG 
AACTGTGTGG ATTGCAAAGG GGGCATCATT GTGAGTGGCT CCAGGGACAG GACGGCCAAG 
GTGTGGCCTT TGGCCTCAGG CCGGCTGGGG CAGTGCTTAC ACACCATCCA GACTGAAGAC 
CGAGTCTGGT CCATTGCTAT CAGCCCATTA CTCAGCTCTT TTGTGACAGG GACGGCTTGT 
TGCGGGCACT TCTCACCCCT GAGAATCTGG GACCTCAACA GTGGGCAGCT GATGACACAC 
TTGGGCAGTG ACTTTCCCCC AGGGGCTGGG GTGCTGGATG TCATGTATGA GTCCCCTTTC 
ACACTGCTGT CCTGTGGCTA TGACACCTAT GTTCGCTACT GGGACCTCCG CACCAGCGTC 
CGGAAATGTG TCATGGAGTG GGAGGAGCCC CACGACAGCA CCCTGTACTG CCTGCAGACA 
GATGGCAACC ACCTGCTGGC CACAGGTTCC TCCTACTACG GTGTTGTACG GCTGTGGGAC 
CGGCGTCAAA GGGCCTGCCT GCACGCCTTC CCGCTGACGT CGACTCCCCT CAGCAGCCCT 
GTGTACTGCC TGCGTCTCAC CACCAAGCAT CTCTATGCTG CCCTGTCTTA CAACCTCCAC 
GTCCTGGATT TTCAAAACCC ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071322.2
CDS	66..1769
Translation	MGSQGRSGPPGNGGPGEGEGGEARKLQEGRVARGKRRKGKGKGKARAGQGGRGSGAEGKPGPQTAKEAAGPGADAGARACPREEAEGGRSVEEGARGIVKGVEGSAGAGKEAQGREYGKKEEWRVRARRREGARPGRAQGRGGQAWADIAGTGVAMAAAAGEEEEEEEAARESAARPAAGPALWRLPEELLLLICSYLDMRALGRLAQVCRWLRRFTSCDLLWRRIARASLNSGFTRLGTDLMTSVPVKERVKVSQNWRLGRCREGILLKWRCSQMPWMQLEDDSLYISQANFILAYQFRPDGASLNRRPLGVFAGHDEDVCHFVLANSHIVSAGGDGKIGIHKIHSTFTVKYSAHEQEVNCVDCKGGIIVSGSRDRTAKVWPLASGRLGQCLHTIQTEDRVWSIAISPLLSSFVTGTACCGHFSPLRIWDLNSGQLMTHLGSDFPPGAGVLDVMYESPFTLLSCGYDTYVRYWDLRTSVRKCVMEWEEPHDSTLYCLQTDGNHLLATGSSYYGVVRLWDRRQRACLHAFPLTSTPLSSPVYCLRLTTKHLYAALSYNLHVLDFQNP

Target ORF information:

RefSeq Version	NM_022039.4
Organism	Homo sapiens(human)
Definition	Homo sapiens F-box and WD repeat domain containing 4 (FBXW4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022039.4

ORF Insert Sequence:

ATGGGCAGCC AGGGCCGCTC GGGGCCCCCC GGGAACGGCG GGCCCGGCGA GGGCGAGGGC 
GGAGAGGCGA GGAAGCTGCA GGAAGGGAGG GTGGCGAGGG GGAAGCGAAG GAAGGGGAAG 
GGGAAGGGAA AAGCGAGAGC GGGGCAAGGC GGAAGAGGAA GCGGGGCGGA AGGGAAGCCC 
GGGCCGCAGA CGGCGAAGGA GGCAGCCGGG CCGGGGGCTG ACGCGGGAGC GAGGGCATGC 
CCAAGGGAGG AAGCAGAGGG AGGCAGAAGC GTGGAGGAAG GGGCGAGAGG CATCGTCAAG 
GGAGTCGAGG GGAGCGCAGG GGCCGGGAAG GAGGCACAAG GAAGAGAGTA TGGGAAGAAG 
GAGGAATGGA GGGTCAGGGC TAGGCGGCGG GAGGGCGCCA GGCCGGGAAG AGCACAGGGA 
CGAGGGGGTC AGGCTTGGGC CGACATCGCG GGGACAGGGG TGGCCATGGC GGCGGCGGCC 
GGGGAGGAGG AGGAGGAGGA GGAGGCGGCT CGGGAGTCGG CTGCCCGCCC GGCCGCGGGG 
CCTGCGCTCT GGCGCCTGCC GGAGGAGCTG CTGCTGCTCA TCTGCTCCTA CCTGGACATG 
CGGGCCCTCG GCCGCCTGGC CCAGGTGTGC CGCTGGCTGC GGCGCTTCAC CAGCTGCGAT 
CTGCTCTGGC GCCGGATAGC CCGGGCCTCG CTCAACTCCG GCTTCACGCG GCTCGGCACC 
GACCTGATGA CCAGTGTCCC AGTGAAGGAA CGAGTGAAGG TGTCTCAGAA CTGGAGACTG 
GGGCGCTGCC GAGAGGGGAT TCTGCTGAAG TGGAGATGCA GTCAGATGCC CTGGATGCAG 
CTAGAGGATG ATTCTCTGTA CATATCCCAG GCTAATTTCA TCCTGGCCTA CCAGTTCCGT 
CCAGATGGTG CCAGCTTGAA TCGTCGGCCT CTGGGAGTCT TTGCTGGGCA TGATGAGGAC 
GTTTGCCACT TTGTGCTGGC CAACTCGCAT ATTGTTAGTG CAGGAGGGGA TGGGAAGATT 
GGCATTCATA AGATTCACAG CACCTTCACT GTCAAGTACT CGGCTCATGA ACAGGAGGTG 
AACTGTGTGG ATTGCAAAGG GGGCATCATT GTGAGTGGCT CCAGGGACAG GACGGCCAAG 
GTGTGGCCTT TGGCCTCAGG CCGGCTGGGG CAGTGCTTAC ACACCATCCA GACTGAAGAC 
CGAGTCTGGT CCATTGCTAT CAGCCCATTA CTCAGCTCTT TTGTGACAGG GACGGCTTGT 
TGCGGGCACT TCTCACCCCT GAGAATCTGG GACCTCAACA GTGGGCAGCT GATGACACAC 
TTGGGCAGTG ACTTTCCCCC AGGGGCTGGG GTGCTGGATG TCATGTATGA GTCCCCTTTC 
ACACTGCTGT CCTGTGGCTA TGACACCTAT GTTCGCTACT GGGACCTCCG CACCAGCGTC 
CGGAAATGTG TCATGGAGTG GGAGGAGCCC CACGACAGCA CCCTGTACTG CCTGCAGACA 
GATGGCAACC ACCTGCTGGC CACAGGTTCC TCCTACTACG GTGTTGTACG GCTGTGGGAC 
CGGCGTCAAA GGGCCTGCCT GCACGCCTTC CCGCTGACGT CGACTCCCCT CAGCAGCCCT 
GTGTACTGCC TGCGTCTCAC CACCAAGCAT CTCTATGCTG CCCTGTCTTA CAACCTCCAC 
GTCCTGGATT TTCAAAACCC ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FBXW4 ( XM_005270053.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_005270110.2 Homo sapiens F-box and WD repeat domain containing 4 (FBXW4), transcript variant X1, mRNA.

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CloneID	OHu60490
Clone ID Related Accession (Same CDS sequence)	XM_005270053.2 , XM_005270053.3
Accession Version	XM_005270053.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1311bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	F-box/WD repeat-containing protein 4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced XM_005270053.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGCGG CGGCCGGGGA GGAGGAGGAG GAGGAGGAGG CGGCTCGGGA GTCGGCTGCC 
CGCCCGGCCG CGGGGCCTGC GCTCTGGCGC CTGCCGGAGG AGCTGCTGCT GCTCATCTGC 
TCCTACCTGG ACATGCGGGC CCTCGGCCGC CTGGCCCAGG TGTGCCGCTG GCTGCGGCGC 
TTCACCAGCT GCGATCTGCT CTGGCGCCGG ATAGCCCGGG CCTCGCTCAA CTCCGGCTTC 
ACGCGGCTCG GCACCGACCT GATGACCAGT GTCCCAGTGA AGGAACGAGT GAAGGTGTCT 
CAGAACTGGA GACTGGGGCG CTGCCGAGAG GGGATTCTGC TGAAGTGGAG ATGCAGTCAG 
ATGCCCTGGA TGCAGCTAGA GGATGATTCT CTGTACATAT CCCAGGCTAA TTTCATCCTG 
GCCTACCAGT TCCGTCCAGA TGGTGCCAGC TTGAATCGTC GGCCTCTGGG AGTCTTTGCT 
GGGCATGATG AGGACGTTTG CCACTTTGTG CTGGCCAACT CGCATATTGT TAGTGCAGGA 
GGGGATGGGA AGATTGGCAT TCATAAGATT CACAGCACCT TCACTGTCAA GTACTCGGCT 
CATGAACAGG AGGTGAACTG TGTGGATTGC AAAGGGGGCA TCATTGTGAG TGGCTCCAGG 
GACAGGACGG CCAAGGTGTG GCCTTTGGCC TCAGGCCGGC TGGGGCAGTG CTTACACACC 
ATCCAGACTG AAGACCGAGT CTGGTCCATT GCTATCAGCC CATTACTCAG CACAGGAGCC 
AGCACCGTGA GGGATGTGAC GAGAATCTGG TTGAAGACAT CTCGCGGATT CAAATCGAAC 
AGCTCTTTTG TGACAGGGAC GGCTTGTTGC GGGCACTTCT CACCCCTGAG AATCTGGGAC 
CTCAACAGTG GGCAGCTGAT GACACACTTG GGCAGTGACT TTCCCCCAGG GGCTGGGGTG 
CTGGATGTCA TGTATGAGTC CCCTTTCACA CTGCTGTCCT GTGGCTATGA CACCTATGTT 
CGCTACTGGG ACCTCCGCAC CAGCGTCCGG AAATGTGTCA TGGAGTGGGA GGAGCCCCAC 
GACAGCACCC TGTACTGCCT GCAGACAGAT GGCAACCACC TGCTGGCCAC AGGTTCCTCC 
TACTACGGTG TTGTACGGCT GTGGGACCGG CGTCAAAGGG CCTGCCTGCA CGCCTTCCCG 
CTGACGTCGA CTCCCCTCAG CAGCCCTGTG TACTGCCTGC GTCTCACCAC CAAGCATCTC 
TATGCTGCCC TGTCTTACAA CCTCCACGTC CTGGATTTTC AAAACCCATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005270110.2
CDS	398..1708
Translation	MAAAAGEEEEEEEAARESAARPAAGPALWRLPEELLLLICSYLDMRALGRLAQVCRWLRRFTSCDLLWRRIARASLNSGFTRLGTDLMTSVPVKERVKVSQNWRLGRCREGILLKWRCSQMPWMQLEDDSLYISQANFILAYQFRPDGASLNRRPLGVFAGHDEDVCHFVLANSHIVSAGGDGKIGIHKIHSTFTVKYSAHEQEVNCVDCKGGIIVSGSRDRTAKVWPLASGRLGQCLHTIQTEDRVWSIAISPLLSTGASTVRDVTRIWLKTSRGFKSNSSFVTGTACCGHFSPLRIWDLNSGQLMTHLGSDFPPGAGVLDVMYESPFTLLSCGYDTYVRYWDLRTSVRKCVMEWEEPHDSTLYCLQTDGNHLLATGSSYYGVVRLWDRRQRACLHAFPLTSTPLSSPVYCLRLTTKHLYAALSYNLHVLDFQNP

Target ORF information:

RefSeq Version	XM_005270053.2
Organism	Homo sapiens(human)
Definition	Homo sapiens F-box and WD repeat domain containing 4 (FBXW4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005270053.2

ORF Insert Sequence:

ATGGCGGCGG CGGCCGGGGA GGAGGAGGAG GAGGAGGAGG CGGCTCGGGA GTCGGCTGCC 
CGCCCGGCCG CGGGGCCTGC GCTCTGGCGC CTGCCGGAGG AGCTGCTGCT GCTCATCTGC 
TCCTACCTGG ACATGCGGGC CCTCGGCCGC CTGGCCCAGG TGTGCCGCTG GCTGCGGCGC 
TTCACCAGCT GCGATCTGCT CTGGCGCCGG ATAGCCCGGG CCTCGCTCAA CTCCGGCTTC 
ACGCGGCTCG GCACCGACCT GATGACCAGT GTCCCAGTGA AGGAACGAGT GAAGGTGTCT 
CAGAACTGGA GACTGGGGCG CTGCCGAGAG GGGATTCTGC TGAAGTGGAG ATGCAGTCAG 
ATGCCCTGGA TGCAGCTAGA GGATGATTCT CTGTACATAT CCCAGGCTAA TTTCATCCTG 
GCCTACCAGT TCCGTCCAGA TGGTGCCAGC TTGAATCGTC GGCCTCTGGG AGTCTTTGCT 
GGGCATGATG AGGACGTTTG CCACTTTGTG CTGGCCAACT CGCATATTGT TAGTGCAGGA 
GGGGATGGGA AGATTGGCAT TCATAAGATT CACAGCACCT TCACTGTCAA GTACTCGGCT 
CATGAACAGG AGGTGAACTG TGTGGATTGC AAAGGGGGCA TCATTGTGAG TGGCTCCAGG 
GACAGGACGG CCAAGGTGTG GCCTTTGGCC TCAGGCCGGC TGGGGCAGTG CTTACACACC 
ATCCAGACTG AAGACCGAGT CTGGTCCATT GCTATCAGCC CATTACTCAG CACAGGAGCC 
AGCACCGTGA GGGATGTGAC GAGAATCTGG TTGAAGACAT CTCGCGGATT CAAATCGAAC 
AGCTCTTTTG TGACAGGGAC GGCTTGTTGC GGGCACTTCT CACCCCTGAG AATCTGGGAC 
CTCAACAGTG GGCAGCTGAT GACACACTTG GGCAGTGACT TTCCCCCAGG GGCTGGGGTG 
CTGGATGTCA TGTATGAGTC CCCTTTCACA CTGCTGTCCT GTGGCTATGA CACCTATGTT 
CGCTACTGGG ACCTCCGCAC CAGCGTCCGG AAATGTGTCA TGGAGTGGGA GGAGCCCCAC 
GACAGCACCC TGTACTGCCT GCAGACAGAT GGCAACCACC TGCTGGCCAC AGGTTCCTCC 
TACTACGGTG TTGTACGGCT GTGGGACCGG CGTCAAAGGG CCTGCCTGCA CGCCTTCCCG 
CTGACGTCGA CTCCCCTCAG CAGCCCTGTG TACTGCCTGC GTCTCACCAC CAAGCATCTC 
TATGCTGCCC TGTCTTACAA CCTCCACGTC CTGGATTTTC AAAACCCATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FBXW4 ( XM_005270053.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005270110.2 Homo sapiens F-box and WD repeat domain containing 4 (FBXW4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu60490
Clone ID Related Accession (Same CDS sequence)	XM_005270053.2 , XM_005270053.3
Accession Version	XM_005270053.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1311bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	F-box/WD repeat-containing protein 4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_005270053.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGCGG CGGCCGGGGA GGAGGAGGAG GAGGAGGAGG CGGCTCGGGA GTCGGCTGCC 
CGCCCGGCCG CGGGGCCTGC GCTCTGGCGC CTGCCGGAGG AGCTGCTGCT GCTCATCTGC 
TCCTACCTGG ACATGCGGGC CCTCGGCCGC CTGGCCCAGG TGTGCCGCTG GCTGCGGCGC 
TTCACCAGCT GCGATCTGCT CTGGCGCCGG ATAGCCCGGG CCTCGCTCAA CTCCGGCTTC 
ACGCGGCTCG GCACCGACCT GATGACCAGT GTCCCAGTGA AGGAACGAGT GAAGGTGTCT 
CAGAACTGGA GACTGGGGCG CTGCCGAGAG GGGATTCTGC TGAAGTGGAG ATGCAGTCAG 
ATGCCCTGGA TGCAGCTAGA GGATGATTCT CTGTACATAT CCCAGGCTAA TTTCATCCTG 
GCCTACCAGT TCCGTCCAGA TGGTGCCAGC TTGAATCGTC GGCCTCTGGG AGTCTTTGCT 
GGGCATGATG AGGACGTTTG CCACTTTGTG CTGGCCAACT CGCATATTGT TAGTGCAGGA 
GGGGATGGGA AGATTGGCAT TCATAAGATT CACAGCACCT TCACTGTCAA GTACTCGGCT 
CATGAACAGG AGGTGAACTG TGTGGATTGC AAAGGGGGCA TCATTGTGAG TGGCTCCAGG 
GACAGGACGG CCAAGGTGTG GCCTTTGGCC TCAGGCCGGC TGGGGCAGTG CTTACACACC 
ATCCAGACTG AAGACCGAGT CTGGTCCATT GCTATCAGCC CATTACTCAG CACAGGAGCC 
AGCACCGTGA GGGATGTGAC GAGAATCTGG TTGAAGACAT CTCGCGGATT CAAATCGAAC 
AGCTCTTTTG TGACAGGGAC GGCTTGTTGC GGGCACTTCT CACCCCTGAG AATCTGGGAC 
CTCAACAGTG GGCAGCTGAT GACACACTTG GGCAGTGACT TTCCCCCAGG GGCTGGGGTG 
CTGGATGTCA TGTATGAGTC CCCTTTCACA CTGCTGTCCT GTGGCTATGA CACCTATGTT 
CGCTACTGGG ACCTCCGCAC CAGCGTCCGG AAATGTGTCA TGGAGTGGGA GGAGCCCCAC 
GACAGCACCC TGTACTGCCT GCAGACAGAT GGCAACCACC TGCTGGCCAC AGGTTCCTCC 
TACTACGGTG TTGTACGGCT GTGGGACCGG CGTCAAAGGG CCTGCCTGCA CGCCTTCCCG 
CTGACGTCGA CTCCCCTCAG CAGCCCTGTG TACTGCCTGC GTCTCACCAC CAAGCATCTC 
TATGCTGCCC TGTCTTACAA CCTCCACGTC CTGGATTTTC AAAACCCATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005270110.2
CDS	244..1554
Translation	MAAAAGEEEEEEEAARESAARPAAGPALWRLPEELLLLICSYLDMRALGRLAQVCRWLRRFTSCDLLWRRIARASLNSGFTRLGTDLMTSVPVKERVKVSQNWRLGRCREGILLKWRCSQMPWMQLEDDSLYISQANFILAYQFRPDGASLNRRPLGVFAGHDEDVCHFVLANSHIVSAGGDGKIGIHKIHSTFTVKYSAHEQEVNCVDCKGGIIVSGSRDRTAKVWPLASGRLGQCLHTIQTEDRVWSIAISPLLSTGASTVRDVTRIWLKTSRGFKSNSSFVTGTACCGHFSPLRIWDLNSGQLMTHLGSDFPPGAGVLDVMYESPFTLLSCGYDTYVRYWDLRTSVRKCVMEWEEPHDSTLYCLQTDGNHLLATGSSYYGVVRLWDRRQRACLHAFPLTSTPLSSPVYCLRLTTKHLYAALSYNLHVLDFQNP

Target ORF information:

RefSeq Version	XM_005270053.3
Organism	Homo sapiens(human)
Definition	Homo sapiens F-box and WD repeat domain containing 4 (FBXW4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005270053.3

ORF Insert Sequence:

ATGGCGGCGG CGGCCGGGGA GGAGGAGGAG GAGGAGGAGG CGGCTCGGGA GTCGGCTGCC 
CGCCCGGCCG CGGGGCCTGC GCTCTGGCGC CTGCCGGAGG AGCTGCTGCT GCTCATCTGC 
TCCTACCTGG ACATGCGGGC CCTCGGCCGC CTGGCCCAGG TGTGCCGCTG GCTGCGGCGC 
TTCACCAGCT GCGATCTGCT CTGGCGCCGG ATAGCCCGGG CCTCGCTCAA CTCCGGCTTC 
ACGCGGCTCG GCACCGACCT GATGACCAGT GTCCCAGTGA AGGAACGAGT GAAGGTGTCT 
CAGAACTGGA GACTGGGGCG CTGCCGAGAG GGGATTCTGC TGAAGTGGAG ATGCAGTCAG 
ATGCCCTGGA TGCAGCTAGA GGATGATTCT CTGTACATAT CCCAGGCTAA TTTCATCCTG 
GCCTACCAGT TCCGTCCAGA TGGTGCCAGC TTGAATCGTC GGCCTCTGGG AGTCTTTGCT 
GGGCATGATG AGGACGTTTG CCACTTTGTG CTGGCCAACT CGCATATTGT TAGTGCAGGA 
GGGGATGGGA AGATTGGCAT TCATAAGATT CACAGCACCT TCACTGTCAA GTACTCGGCT 
CATGAACAGG AGGTGAACTG TGTGGATTGC AAAGGGGGCA TCATTGTGAG TGGCTCCAGG 
GACAGGACGG CCAAGGTGTG GCCTTTGGCC TCAGGCCGGC TGGGGCAGTG CTTACACACC 
ATCCAGACTG AAGACCGAGT CTGGTCCATT GCTATCAGCC CATTACTCAG CACAGGAGCC 
AGCACCGTGA GGGATGTGAC GAGAATCTGG TTGAAGACAT CTCGCGGATT CAAATCGAAC 
AGCTCTTTTG TGACAGGGAC GGCTTGTTGC GGGCACTTCT CACCCCTGAG AATCTGGGAC 
CTCAACAGTG GGCAGCTGAT GACACACTTG GGCAGTGACT TTCCCCCAGG GGCTGGGGTG 
CTGGATGTCA TGTATGAGTC CCCTTTCACA CTGCTGTCCT GTGGCTATGA CACCTATGTT 
CGCTACTGGG ACCTCCGCAC CAGCGTCCGG AAATGTGTCA TGGAGTGGGA GGAGCCCCAC 
GACAGCACCC TGTACTGCCT GCAGACAGAT GGCAACCACC TGCTGGCCAC AGGTTCCTCC 
TACTACGGTG TTGTACGGCT GTGGGACCGG CGTCAAAGGG CCTGCCTGCA CGCCTTCCCG 
CTGACGTCGA CTCCCCTCAG CAGCCCTGTG TACTGCCTGC GTCTCACCAC CAAGCATCTC 
TATGCTGCCC TGTCTTACAA CCTCCACGTC CTGGATTTTC AAAACCCATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FBXW4 ( XM_017016570.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_016872059.1 Homo sapiens F-box and WD repeat domain containing 4 (FBXW4), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu91593
Clone ID Related Accession (Same CDS sequence)	XM_017016570.2 , XM_017016570.1
Accession Version	XM_017016570.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 855bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	F-box/WD repeat-containing protein 4 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017016570.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGCGG CGGCCGGGGA GGAGGAGGAG GAGGAGGAGG CGGCTCGGGA GTCGGCTGCC 
CGCCCGGCCG CGGGGCCTGC GCTCTGGCGC CTGCCGGAGG AGCTGCTGCT GCTCATCTGC 
TCCTACCTGG ACATGCGGGC CCTCGGCCGC CTGGCCCAGG TGTGCCGCTG GCTGCGGCGC 
TTCACCAGCT GCGATCTGCT CTGGCGCCGG ATAGCCCGGG CCTCGCTCAA CTCCGGCTTC 
ACGCGGCTCG GCACCGACCT GATGACCAGT GTCCCAGTGA AGGAACGAGT GAAGGTGTCT 
CAGAACTGGA GACTGGGGCG CTGCCGAGAG GGGATTCTGC TGAAGTGGAG ATGCAGTCAG 
ATGCCCTGGA TGCAGCTAGA GGATGATTCT CTGTACATAT CCCAGGCTAA TTTCATCCTG 
GCCTACCAGT TCCGTCCAGA TGGTGCCAGC TTGAATCGTC GGCCTCTGGG AGTCTTTGCT 
GGGCATGATG AGGACGTTTG CCACTTTGTG CTGGCCAACT CGCATATTGT TAGTGCAGGA 
GGGGATGGGA AGATTGGCAT TCATAAGATT CACAGCACCT TCACTGTCAA GTACTCGGCT 
CATGAACAGG AGGTGAACTG TGTGGATTGC AAAGGGGGCA TCATTGTGAG TGGCTCCAGG 
GACAGGACGG CCAAGGTGTG GCCTTTGGCC TCAGGCCGGC TGGGGCAGTG CTTACACACC 
ATCCAGACTG AAGACCGAGT CTGGTCCATT GCTATCAGCC CATTACTCAG CACAGGAGCC 
AGCACCGTGA GGGATGTGAC GAGAATCTGG TTGAAGACAT CTCGCGGATT CAAATCGAAC 
AGGTTCAAGT TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016872059.1
CDS	244..1098
Translation	MAAAAGEEEEEEEAARESAARPAAGPALWRLPEELLLLICSYLDMRALGRLAQVCRWLRRFTSCDLLWRRIARASLNSGFTRLGTDLMTSVPVKERVKVSQNWRLGRCREGILLKWRCSQMPWMQLEDDSLYISQANFILAYQFRPDGASLNRRPLGVFAGHDEDVCHFVLANSHIVSAGGDGKIGIHKIHSTFTVKYSAHEQEVNCVDCKGGIIVSGSRDRTAKVWPLASGRLGQCLHTIQTEDRVWSIAISPLLSTGASTVRDVTRIWLKTSRGFKSNRFKF

Target ORF information:

RefSeq Version	XM_017016570.2
Organism	Homo sapiens(human)
Definition	Homo sapiens F-box and WD repeat domain containing 4 (FBXW4), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017016570.2

ORF Insert Sequence:

ATGGCGGCGG CGGCCGGGGA GGAGGAGGAG GAGGAGGAGG CGGCTCGGGA GTCGGCTGCC 
CGCCCGGCCG CGGGGCCTGC GCTCTGGCGC CTGCCGGAGG AGCTGCTGCT GCTCATCTGC 
TCCTACCTGG ACATGCGGGC CCTCGGCCGC CTGGCCCAGG TGTGCCGCTG GCTGCGGCGC 
TTCACCAGCT GCGATCTGCT CTGGCGCCGG ATAGCCCGGG CCTCGCTCAA CTCCGGCTTC 
ACGCGGCTCG GCACCGACCT GATGACCAGT GTCCCAGTGA AGGAACGAGT GAAGGTGTCT 
CAGAACTGGA GACTGGGGCG CTGCCGAGAG GGGATTCTGC TGAAGTGGAG ATGCAGTCAG 
ATGCCCTGGA TGCAGCTAGA GGATGATTCT CTGTACATAT CCCAGGCTAA TTTCATCCTG 
GCCTACCAGT TCCGTCCAGA TGGTGCCAGC TTGAATCGTC GGCCTCTGGG AGTCTTTGCT 
GGGCATGATG AGGACGTTTG CCACTTTGTG CTGGCCAACT CGCATATTGT TAGTGCAGGA 
GGGGATGGGA AGATTGGCAT TCATAAGATT CACAGCACCT TCACTGTCAA GTACTCGGCT 
CATGAACAGG AGGTGAACTG TGTGGATTGC AAAGGGGGCA TCATTGTGAG TGGCTCCAGG 
GACAGGACGG CCAAGGTGTG GCCTTTGGCC TCAGGCCGGC TGGGGCAGTG CTTACACACC 
ATCCAGACTG AAGACCGAGT CTGGTCCATT GCTATCAGCC CATTACTCAG CACAGGAGCC 
AGCACCGTGA GGGATGTGAC GAGAATCTGG TTGAAGACAT CTCGCGGATT CAAATCGAAC 
AGGTTCAAGT TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FBXW4 ( XM_017016570.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016872059.1 Homo sapiens F-box and WD repeat domain containing 4 (FBXW4), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu91593
Clone ID Related Accession (Same CDS sequence)	XM_017016570.2 , XM_017016570.1
Accession Version	XM_017016570.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 855bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	F-box/WD repeat-containing protein 4 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGCGG CGGCCGGGGA GGAGGAGGAG GAGGAGGAGG CGGCTCGGGA GTCGGCTGCC 
CGCCCGGCCG CGGGGCCTGC GCTCTGGCGC CTGCCGGAGG AGCTGCTGCT GCTCATCTGC 
TCCTACCTGG ACATGCGGGC CCTCGGCCGC CTGGCCCAGG TGTGCCGCTG GCTGCGGCGC 
TTCACCAGCT GCGATCTGCT CTGGCGCCGG ATAGCCCGGG CCTCGCTCAA CTCCGGCTTC 
ACGCGGCTCG GCACCGACCT GATGACCAGT GTCCCAGTGA AGGAACGAGT GAAGGTGTCT 
CAGAACTGGA GACTGGGGCG CTGCCGAGAG GGGATTCTGC TGAAGTGGAG ATGCAGTCAG 
ATGCCCTGGA TGCAGCTAGA GGATGATTCT CTGTACATAT CCCAGGCTAA TTTCATCCTG 
GCCTACCAGT TCCGTCCAGA TGGTGCCAGC TTGAATCGTC GGCCTCTGGG AGTCTTTGCT 
GGGCATGATG AGGACGTTTG CCACTTTGTG CTGGCCAACT CGCATATTGT TAGTGCAGGA 
GGGGATGGGA AGATTGGCAT TCATAAGATT CACAGCACCT TCACTGTCAA GTACTCGGCT 
CATGAACAGG AGGTGAACTG TGTGGATTGC AAAGGGGGCA TCATTGTGAG TGGCTCCAGG 
GACAGGACGG CCAAGGTGTG GCCTTTGGCC TCAGGCCGGC TGGGGCAGTG CTTACACACC 
ATCCAGACTG AAGACCGAGT CTGGTCCATT GCTATCAGCC CATTACTCAG CACAGGAGCC 
AGCACCGTGA GGGATGTGAC GAGAATCTGG TTGAAGACAT CTCGCGGATT CAAATCGAAC 
AGGTTCAAGT TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016872059.1
CDS	398..1252
Translation	MAAAAGEEEEEEEAARESAARPAAGPALWRLPEELLLLICSYLDMRALGRLAQVCRWLRRFTSCDLLWRRIARASLNSGFTRLGTDLMTSVPVKERVKVSQNWRLGRCREGILLKWRCSQMPWMQLEDDSLYISQANFILAYQFRPDGASLNRRPLGVFAGHDEDVCHFVLANSHIVSAGGDGKIGIHKIHSTFTVKYSAHEQEVNCVDCKGGIIVSGSRDRTAKVWPLASGRLGQCLHTIQTEDRVWSIAISPLLSTGASTVRDVTRIWLKTSRGFKSNRFKF

Target ORF information:

RefSeq Version	XM_017016570.1
Organism	Homo sapiens(human)
Definition	Homo sapiens F-box and WD repeat domain containing 4 (FBXW4), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017016570.1

ORF Insert Sequence:

ATGGCGGCGG CGGCCGGGGA GGAGGAGGAG GAGGAGGAGG CGGCTCGGGA GTCGGCTGCC 
CGCCCGGCCG CGGGGCCTGC GCTCTGGCGC CTGCCGGAGG AGCTGCTGCT GCTCATCTGC 
TCCTACCTGG ACATGCGGGC CCTCGGCCGC CTGGCCCAGG TGTGCCGCTG GCTGCGGCGC 
TTCACCAGCT GCGATCTGCT CTGGCGCCGG ATAGCCCGGG CCTCGCTCAA CTCCGGCTTC 
ACGCGGCTCG GCACCGACCT GATGACCAGT GTCCCAGTGA AGGAACGAGT GAAGGTGTCT 
CAGAACTGGA GACTGGGGCG CTGCCGAGAG GGGATTCTGC TGAAGTGGAG ATGCAGTCAG 
ATGCCCTGGA TGCAGCTAGA GGATGATTCT CTGTACATAT CCCAGGCTAA TTTCATCCTG 
GCCTACCAGT TCCGTCCAGA TGGTGCCAGC TTGAATCGTC GGCCTCTGGG AGTCTTTGCT 
GGGCATGATG AGGACGTTTG CCACTTTGTG CTGGCCAACT CGCATATTGT TAGTGCAGGA 
GGGGATGGGA AGATTGGCAT TCATAAGATT CACAGCACCT TCACTGTCAA GTACTCGGCT 
CATGAACAGG AGGTGAACTG TGTGGATTGC AAAGGGGGCA TCATTGTGAG TGGCTCCAGG 
GACAGGACGG CCAAGGTGTG GCCTTTGGCC TCAGGCCGGC TGGGGCAGTG CTTACACACC 
ATCCAGACTG AAGACCGAGT CTGGTCCATT GCTATCAGCC CATTACTCAG CACAGGAGCC 
AGCACCGTGA GGGATGTGAC GAGAATCTGG TTGAAGACAT CTCGCGGATT CAAATCGAAC 
AGGTTCAAGT TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A High-Density Map for Navigating the Human Polycomb Complexome.
Cell reports17(2)583-595(2016 10)
Hauri S,Comoglio F,Seimiya M,Gerstung M,Glatter T,Hansen K,Aebersold R,Paro R,Gstaiger M,Beisel C

The novel ubiquitin ligase complex, SCF(Fbxw4), interacts with the COP9 signalosome in an F-box dependent manner, is mutated, lost and under-expressed in human cancers.
PloS one8(5)e63610(2013)
Lockwood WW,Chandel SK,Stewart GL,Erdjument-Bromage H,Beverly LJ

Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair.
Cell149(5)1023-34(2012 May)
D'Angiolella V,Donato V,Forrester FM,Jeong YT,Pellacani C,Kudo Y,Saraf A,Florens L,Washburn MP,Pagano M

Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system.
The international journal of biochemistry & cell biology41(5)1205-15(2009 May)
Ebstein F,Lange N,Urban S,Seifert U,Kr?ger E,Kloetzel PM

Frequency of genomic rearrangements involving the SHFM3 locus at chromosome 10q24 in syndromic and non-syndromic split-hand/foot malformation.
American journal of medical genetics. Part A140(13)1375-83(2006 Jul)
Everman DB,Morgan CT,Lyle R,Laughridge ME,Bamshad MJ,Clarkson KB,Colby R,Gurrieri F,Innes AM,Roberson J,Schrander-Stumpel C,van Bokhoven H,Antonarakis SE,Schwartz CE

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FBXW4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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