Gene Symbol | CLEC7A |
Entrez Gene ID | 64581 |
Full Name | C-type lectin domain containing 7A |
Synonyms | BGR,CANDF4,CD369,CLECSF12,DECTIN1,SCARE2 |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]. |
Disorder MIM: | |
Disorder Html: | Candidiasis, familial, 4, autosomal recessive, 613108 (3); {Aspergillosis, susceptibility to}, 614079 (3) |