BLVRB cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	BLVRB
Entrez Gene ID	645
Full Name	biliverdin reductase B
Synonyms	BVRB,FLR,HEL-S-10,SDR43U1
General protein information	Preferred Names biliverdin reductase B Names flavin reductase (NADPH) BVR-B FR GHBP NADPH-dependent diaphorase NADPH-flavin reductase biliverdin-IX beta-reductase epididymis secretory protein Li 10 green heme-binding protein short chain dehydrogenase/reductase family 43U, member 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.2
Summary	The final step in heme metabolism in mammals is catalyzed by the cytosolic biliverdin reductase enzymes A and B (EC 1.3.1.24).[supplied by OMIM, Jul 2009].
Disorder MIM:	600941

mRNA and Protein(s)

mRNA	Protein	Name
NM_000713.2	NP_000704.1	flavin reductase (NADPH)
NM_000713.3	NP_000704.1	flavin reductase (NADPH)

Pathways from BioSystems

Homologies

Homo sapiens (human)	BLVRB	NP_000704.1
Pan troglodytes (chimpanzee)	BLVRB	XP_512666.3
Danio rerio (zebrafish)	blvrb	NP_001002686.1
Bos taurus (cattle)	BLVRB	NP_776676.1
Rattus norvegicus (Norway rat)	Blvrb	NP_001099706.1
Drosophila melanogaster (fruit fly)	CG9471	NP_649943.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001321	XP_321824.3
Mus musculus (house mouse)	Blvrb	NP_659172.1
Xenopus tropicalis (tropical clawed frog)	blvrb	NP_001096269.1
	BLVRB	XP_001091330.1
Canis lupus familiaris (dog)	BLVRB	XP_533666.2

Gene Ontology
Bibliography

Related articles in PubMed

BLVRB redox mutation defines heme degradation in a metabolic pathway of enhanced thrombopoiesis in humans.
Wu S, Li Z, Gnatenko DV, Zhang B, Zhao L, Malone LE, Markova N, Mantle TJ, Nesbitt NM, Bahou WF
Blood128(5)699-709(2016 08)

MicroRNA-127-5p targets the biliverdin reductase B/nuclear factor-?B pathway to suppress cell growth in hepatocellular carcinoma cells.
Huan L, Bao C, Chen D, Li Y, Lian J, Ding J, Huang S, Liang L, He X
Cancer science107(3)258-66(2016 Mar)

Biliverdin reductase isozymes in metabolism.
O'Brien L, Hosick PA, John K, Stec DE, Hinds TD Jr
Trends in endocrinology and metabolism: TEM26(4)212-20(2015 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These data define the first physiologically relevant function of BLVRB and implicate its activity and/or heme-regulated BV tetrapyrrole(s) in a unique redox-regulated bioenergetic pathway.
Title: BLVRB redox mutation defines heme degradation in a metabolic pathway of enhanced thrombopoiesis in humans.

miR-127-5p suppressed NF-kappaB activity by directly targeting BLVRB in hepatocellular carcinoma cells.
Title: MicroRNA-127-5p targets the biliverdin reductase B/nuclear factor-?B pathway to suppress cell growth in hepatocellular carcinoma cells.

Data suggest that isoenzymes BVRA and BVRB play different roles in energy metabolism and in pathogenesis of abdominal obesity and hypertriglyceridemia. [REVIEW]
Title: Biliverdin reductase isozymes in metabolism.

quantum mechanics/molecular mechanics potential energy surfaces show that the lowest energy pathway proceeds with a positively charged pyrrole intermediate via two transition states
Title: Computational and experimental studies on the catalytic mechanism of biliverdin-IXbeta reductase.

The following BLVRB gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BLVRB cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu08883	NM_000713.3 Latest version!	Homo sapiens biliverdin reductase B (BLVRB), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu08883	NM_000713.2	Homo sapiens biliverdin reductase B (BLVRB), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

BLVRB ( NM_000713.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_000704.1 Homo sapiens biliverdin reductase B (BLVRB), mRNA.

Price & Availability↑

CloneID	OHu08883
Clone ID Related Accession (Same CDS sequence)	NM_000713.2 , NM_000713.3
Accession Version	NM_000713.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 621bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-19
Organism	Homo sapiens(human)
Product	flavin reductase (NADPH)
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BG340491.1, BC109371.1 and BU528444.1. On Feb 21, 2008 this sequence version replaced NM_000713.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: EU794593.1, BU164235.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2149004 [ECO:0000348] ##Evidence-Data-END##

ATGGCCGTCA AGAAGATCGC GATCTTCGGC GCCACTGGCC AGACCGGGCT CACCACCCTG 
GCGCAGGCGG TGCAAGCAGG TTACGAAGTG ACAGTGCTGG TGCGGGACTC CTCCAGGCTG 
CCATCAGAGG GGCCCCGGCC GGCCCACGTG GTAGTGGGAG ATGTTCTGCA GGCAGCCGAT 
GTGGACAAGA CCGTGGCTGG GCAGGACGCT GTCATCGTGC TGCTGGGCAC CCGCAATGAC 
CTCAGTCCCA CGACAGTGAT GTCCGAGGGC GCCCGGAACA TTGTGGCAGC CATGAAGGCT 
CATGGTGTGG ACAAGGTCGT GGCCTGCACC TCGGCTTTCC TGCTCTGGGA CCCTACCAAG 
GTGCCCCCAC GACTGCAGGC TGTGACTGAT GACCACATCC GGATGCACAA GGTGCTGCGG 
GAATCAGGCC TGAAGTACGT GGCTGTGATG CCGCCACACA TAGGAGACCA GCCACTAACT 
GGGGCGTACA CAGTGACCCT GGATGGACGA GGGCCCTCAA GGGTCATCTC CAAACATGAC 
CTGGGCCATT TCATGCTGCG CTGCCTCACC ACCGATGAGT ACGACGGACA CAGCACCTAC 
CCCTCCCACC AGTACCAGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000704.1
CDS	131..751
Translation	MAVKKIAIFGATGQTGLTTLAQAVQAGYEVTVLVRDSSRLPSEGPRPAHVVVGDVLQAADVDKTVAGQDAVIVLLGTRNDLSPTTVMSEGARNIVAAMKAHGVDKVVACTSAFLLWDPTKVPPRLQAVTDDHIRMHKVLRESGLKYVAVMPPHIGDQPLTGAYTVTLDGRGPSRVISKHDLGHFMLRCLTTDEYDGHSTYPSHQYQ

Target ORF information:

RefSeq Version	NM_000713.2
Organism	Homo sapiens(human)
Definition	Homo sapiens biliverdin reductase B (BLVRB), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000713.2

ORF Insert Sequence:

ATGGCCGTCA AGAAGATCGC GATCTTCGGC GCCACTGGCC AGACCGGGCT CACCACCCTG 
GCGCAGGCGG TGCAAGCAGG TTACGAAGTG ACAGTGCTGG TGCGGGACTC CTCCAGGCTG 
CCATCAGAGG GGCCCCGGCC GGCCCACGTG GTAGTGGGAG ATGTTCTGCA GGCAGCCGAT 
GTGGACAAGA CCGTGGCTGG GCAGGACGCT GTCATCGTGC TGCTGGGCAC CCGCAATGAC 
CTCAGTCCCA CGACAGTGAT GTCCGAGGGC GCCCGGAACA TTGTGGCAGC CATGAAGGCT 
CATGGTGTGG ACAAGGTCGT GGCCTGCACC TCGGCTTTCC TGCTCTGGGA CCCTACCAAG 
GTGCCCCCAC GACTGCAGGC TGTGACTGAT GACCACATCC GGATGCACAA GGTGCTGCGG 
GAATCAGGCC TGAAGTACGT GGCTGTGATG CCGCCACACA TAGGAGACCA GCCACTAACT 
GGGGCGTACA CAGTGACCCT GGATGGACGA GGGCCCTCAA GGGTCATCTC CAAACATGAC 
CTGGGCCATT TCATGCTGCG CTGCCTCACC ACCGATGAGT ACGACGGACA CAGCACCTAC 
CCCTCCCACC AGTACCAGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BLVRB ( NM_000713.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000704.1 Homo sapiens biliverdin reductase B (BLVRB), mRNA.

Price & Availability↑

CloneID	OHu08883
Clone ID Related Accession (Same CDS sequence)	NM_000713.2 , NM_000713.3
Accession Version	NM_000713.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 621bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	flavin reductase (NADPH)
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BG340491.1, BC109371.1, BU528444.1 and AC010271.8. On May 17, 2019 this sequence version replaced NM_000713.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7346977.298786.1, AK312137.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2149004 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000263368.9/ ENSP00000263368.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGCCGTCA AGAAGATCGC GATCTTCGGC GCCACTGGCC AGACCGGGCT CACCACCCTG 
GCGCAGGCGG TGCAAGCAGG TTACGAAGTG ACAGTGCTGG TGCGGGACTC CTCCAGGCTG 
CCATCAGAGG GGCCCCGGCC GGCCCACGTG GTAGTGGGAG ATGTTCTGCA GGCAGCCGAT 
GTGGACAAGA CCGTGGCTGG GCAGGACGCT GTCATCGTGC TGCTGGGCAC CCGCAATGAC 
CTCAGTCCCA CGACAGTGAT GTCCGAGGGC GCCCGGAACA TTGTGGCAGC CATGAAGGCT 
CATGGTGTGG ACAAGGTCGT GGCCTGCACC TCGGCTTTCC TGCTCTGGGA CCCTACCAAG 
GTGCCCCCAC GACTGCAGGC TGTGACTGAT GACCACATCC GGATGCACAA GGTGCTGCGG 
GAATCAGGCC TGAAGTACGT GGCTGTGATG CCGCCACACA TAGGAGACCA GCCACTAACT 
GGGGCGTACA CAGTGACCCT GGATGGACGA GGGCCCTCAA GGGTCATCTC CAAACATGAC 
CTGGGCCATT TCATGCTGCG CTGCCTCACC ACCGATGAGT ACGACGGACA CAGCACCTAC 
CCCTCCCACC AGTACCAGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000704.1
CDS	58..678
Translation	MAVKKIAIFGATGQTGLTTLAQAVQAGYEVTVLVRDSSRLPSEGPRPAHVVVGDVLQAADVDKTVAGQDAVIVLLGTRNDLSPTTVMSEGARNIVAAMKAHGVDKVVACTSAFLLWDPTKVPPRLQAVTDDHIRMHKVLRESGLKYVAVMPPHIGDQPLTGAYTVTLDGRGPSRVISKHDLGHFMLRCLTTDEYDGHSTYPSHQYQ

Target ORF information:

RefSeq Version	NM_000713.3
Organism	Homo sapiens(human)
Definition	Homo sapiens biliverdin reductase B (BLVRB), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000713.3

ORF Insert Sequence:

ATGGCCGTCA AGAAGATCGC GATCTTCGGC GCCACTGGCC AGACCGGGCT CACCACCCTG 
GCGCAGGCGG TGCAAGCAGG TTACGAAGTG ACAGTGCTGG TGCGGGACTC CTCCAGGCTG 
CCATCAGAGG GGCCCCGGCC GGCCCACGTG GTAGTGGGAG ATGTTCTGCA GGCAGCCGAT 
GTGGACAAGA CCGTGGCTGG GCAGGACGCT GTCATCGTGC TGCTGGGCAC CCGCAATGAC 
CTCAGTCCCA CGACAGTGAT GTCCGAGGGC GCCCGGAACA TTGTGGCAGC CATGAAGGCT 
CATGGTGTGG ACAAGGTCGT GGCCTGCACC TCGGCTTTCC TGCTCTGGGA CCCTACCAAG 
GTGCCCCCAC GACTGCAGGC TGTGACTGAT GACCACATCC GGATGCACAA GGTGCTGCGG 
GAATCAGGCC TGAAGTACGT GGCTGTGATG CCGCCACACA TAGGAGACCA GCCACTAACT 
GGGGCGTACA CAGTGACCCT GGATGGACGA GGGCCCTCAA GGGTCATCTC CAAACATGAC 
CTGGGCCATT TCATGCTGCG CTGCCTCACC ACCGATGAGT ACGACGGACA CAGCACCTAC 
CCCTCCCACC AGTACCAGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

BLVRB redox mutation defines heme degradation in a metabolic pathway of enhanced thrombopoiesis in humans.
Blood128(5)699-709(2016 08)
Wu S,Li Z,Gnatenko DV,Zhang B,Zhao L,Malone LE,Markova N,Mantle TJ,Nesbitt NM,Bahou WF

MicroRNA-127-5p targets the biliverdin reductase B/nuclear factor-?B pathway to suppress cell growth in hepatocellular carcinoma cells.
Cancer science107(3)258-66(2016 Mar)
Huan L,Bao C,Chen D,Li Y,Lian J,Ding J,Huang S,Liang L,He X

Biliverdin reductase isozymes in metabolism.
Trends in endocrinology and metabolism: TEM26(4)212-20(2015 Apr)
O'Brien L,Hosick PA,John K,Stec DE,Hinds TD Jr

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BLVRB cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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