SGCB cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SGCB
Entrez Gene ID	6443
Full Name	sarcoglycan beta
Synonyms	A3b,LGMD2E,SGC
General protein information	Preferred Names sarcoglycan beta Names beta-sarcoglycan 43 kDa dystrophin-associated glycoprotein 43DAG beta-SG beta-sarcoglycan(43kD dystrophin-associated glycoprotein) limb girdle muscular dystrophy 2E (non-linked families) sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q12
Summary	This gene encodes a member of the sarcoglycan family. Sarcoglycans are transmembrane components in the dystrophin-glycoprotein complex which help stabilize the muscle fiber membranes and link the muscle cytoskeleton to the extracellular matrix. Mutations in this gene have been associated with limb-girdle muscular dystrophy.[provided by RefSeq, Oct 2008].
Disorder MIM:	600900
Disorder Html:	Muscular dystrophy, limb-girdle, type 2E, 604286 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000232.5	NP_000223.1	beta-sarcoglycan
NM_000232.4	NP_000223.1	beta-sarcoglycan

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Sgcb	NP_001177997.1
Gallus gallus (chicken)	SGCB	NP_001026326.1
Homo sapiens (human)	SGCB	NP_000223.1
Pan troglodytes (chimpanzee)	SGCB	XP_517299.2
Canis lupus familiaris (dog)	SGCB	XP_853790.1
Xenopus tropicalis (tropical clawed frog)	sgcb	NP_001135484.1
Bos taurus (cattle)	SGCB	NP_001095658.1
Danio rerio (zebrafish)	sgcb	NP_001030145.1
	SGCB	XP_001090970.1
Mus musculus (house mouse)	Sgcb	NP_036020.1

Gene Ontology
Bibliography

Related articles in PubMed

LGMD2E is the most common type of sarcoglycanopathies in the ian population.
Alavi A, Esmaeili S, Nilipour Y, Nafissi S, Tonekaboni SH, Zamani G, Ashrafi MR, Kahrizi K, Najmabadi H, Jazayeri F
Journal of neurogenetics31(3)161-169(2017 Sep)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Clinical and genetic spectrum in limb-girdle muscular dystrophy type 2E.
Semplicini C, Vissing J, Dahlqvist JR, Stojkovic T, Bello L, Witting N, Duno M, Leturcq F, Bertolin C, D'Ambrosio P, Eymard B, Angelini C, Politano L, Lafor?t P, Pegoraro E
Neurology84(17)1772-81(2015 Apr)

Sarcoglycanopathies: can muscle immunoanalysis predict the genotype?
Klinge L, Dekomien G, Aboumousa A, Charlton R, Epplen JT, Barresi R, Bushby K, Straub V
Neuromuscular disorders : NMD18(12)934-41(2008 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Clinical severity of limb-girdle muscular dystrophy type 2Emay be predicted by SGCB gene mutation and sarcoglycan protein expression.
Title: Clinical and genetic spectrum in limb-girdle muscular dystrophy type 2E.

The limb-girdle muscular dystrophy patients with beta-sarcoglycan deficient LGMD2E do not enable an accurate prediction of the genotype.
Title: Sarcoglycanopathies: can muscle immunoanalysis predict the genotype?

These data suggest that formation of the beta-delta-core may promote the export and deposition of sarcoglycan subcomplexes at the plasma membrane, and therefore identifies a mechanism for sarcoglycan transport.
Title: The beta-delta-core of sarcoglycan is essential for deposition at the plasma membrane.

While the quantity of beta-sarcoglycan was nearly normal in the limb girdle muscular dystrophy (LGMD)2E carrier, the levels of dysferlin protein were reduced to 50% of controls in the carriers of LGMD2B.
Title: Muscle protein analysis in the detection of heterozygotes for recessive limb girdle muscular dystrophy type 2B and 2E.

beta-sarcoglycan and SPATA18 may have a role in limb-girdle muscular dystrophy type 2E
Title: Homozygous microdeletion of chromosome 4q11-q12 causes severe limb-girdle muscular dystrophy type 2E with joint hyperlaxity and contractures.

The following SGCB gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SGCB cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21735	NM_000232.5 Latest version!	Homo sapiens sarcoglycan beta (SGCB), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
View Old Accession Versions >>
OHu21735	NM_000232.4	Homo sapiens sarcoglycan beta (SGCB), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SGCB ( NM_000232.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_000223.1 Homo sapiens sarcoglycan beta (SGCB), mRNA.

Price & Availability↑

CloneID	OHu21735
Clone ID Related Accession (Same CDS sequence)	NM_000232.5 , NM_000232.4
Accession Version	NM_000232.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 957bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Homo sapiens(human)
Product	beta-sarcoglycan
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CN483961.1, BC020709.1, AC093858.2 and AK094731.1. On Dec 4, 2019 this sequence version replaced NM_000232.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U31116.1, SRR1803612.81477.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCAG CGGCGGCGGC GGCTGCAGAA CAGCAAAGTT CCAATGGTCC TGTAAAGAAG 
TCCATGCGTG AGAAGGCTGT TGAGAGAAGG AGTGTCAATA AAGAGCACAA CAGTAACTTT 
AAAGCTGGAT ACATTCCGAT TGATGAAGAT CGTCTCCACA AAACAGGGTT GAGAGGAAGA 
AAGGGCAATT TAGCCATCTG TGTGATTATC CTCTTGTTTA TCCTGGCTGT CATCAATTTA 
ATAATAACAC TTGTTATTTG GGCCGTGATT CGCATTGGAC CAAATGGCTG TGATAGTATG 
GAGTTTCATG AAAGTGGCCT GCTTCGATTT AAGCAAGTAT CTGACATGGG AGTGATCCAC 
CCTCTTTATA AAAGCACAGT AGGAGGAAGG CGAAATGAAA ATTTGGTCAT CACTGGCAAC 
AACCAGCCTA TTGTTTTTCA GCAAGGGACA ACAAAGCTCA GTGTAGAAAA CAACAAAACT 
TCTATTACAA GTGACATCGG CATGCAGTTT TTTGACCCGA GGACTCAAAA TATCTTATTC 
AGCACAGACT ATGAAACTCA TGAGTTTCAT TTGCCAAGTG GAGTGAAAAG TTTGAATGTT 
CAAAAGGCAT CTACTGAAAG GATTACCAGC AATGCTACCA GTGATTTAAA TATAAAAGTT 
GATGGGCGTG CTATTGTGCG TGGAAATGAA GGTGTATTCA TTATGGGCAA AACCATTGAA 
TTTCACATGG GTGGTAATAT GGAGTTAAAG GCGGAAAACA GTATCATCCT AAATGGATCT 
GTGATGGTCA GCACCACCCG CCTACCCAGT TCCTCCAGTG GAGACCAGTT GGGTAGTGGT 
GACTGGGTAC GCTACAAGCT CTGCATGTGT GCTGATGGGA CGCTCTTCAA GGTGCAAGTA 
ACCAGCCAGA ACATGGGCTG CCAAATCTCA GACAACCCCT GTGGAAACAC TCATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000223.1
CDS	41..997
Translation	MAAAAAAAAEQQSSNGPVKKSMREKAVERRSVNKEHNSNFKAGYIPIDEDRLHKTGLRGRKGNLAICVIILLFILAVINLIITLVIWAVIRIGPNGCDSMEFHESGLLRFKQVSDMGVIHPLYKSTVGGRRNENLVITGNNQPIVFQQGTTKLSVENNKTSITSDIGMQFFDPRTQNILFSTDYETHEFHLPSGVKSLNVQKASTERITSNATSDLNIKVDGRAIVRGNEGVFIMGKTIEFHMGGNMELKAENSIILNGSVMVSTTRLPSSSSGDQLGSGDWVRYKLCMCADGTLFKVQVTSQNMGCQISDNPCGNTH

Target ORF information:

RefSeq Version	NM_000232.5
Organism	Homo sapiens(human)
Definition	Homo sapiens sarcoglycan beta (SGCB), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000232.5

ORF Insert Sequence:

ATGGCGGCAG CGGCGGCGGC GGCTGCAGAA CAGCAAAGTT CCAATGGTCC TGTAAAGAAG 
TCCATGCGTG AGAAGGCTGT TGAGAGAAGG AGTGTCAATA AAGAGCACAA CAGTAACTTT 
AAAGCTGGAT ACATTCCGAT TGATGAAGAT CGTCTCCACA AAACAGGGTT GAGAGGAAGA 
AAGGGCAATT TAGCCATCTG TGTGATTATC CTCTTGTTTA TCCTGGCTGT CATCAATTTA 
ATAATAACAC TTGTTATTTG GGCCGTGATT CGCATTGGAC CAAATGGCTG TGATAGTATG 
GAGTTTCATG AAAGTGGCCT GCTTCGATTT AAGCAAGTAT CTGACATGGG AGTGATCCAC 
CCTCTTTATA AAAGCACAGT AGGAGGAAGG CGAAATGAAA ATTTGGTCAT CACTGGCAAC 
AACCAGCCTA TTGTTTTTCA GCAAGGGACA ACAAAGCTCA GTGTAGAAAA CAACAAAACT 
TCTATTACAA GTGACATCGG CATGCAGTTT TTTGACCCGA GGACTCAAAA TATCTTATTC 
AGCACAGACT ATGAAACTCA TGAGTTTCAT TTGCCAAGTG GAGTGAAAAG TTTGAATGTT 
CAAAAGGCAT CTACTGAAAG GATTACCAGC AATGCTACCA GTGATTTAAA TATAAAAGTT 
GATGGGCGTG CTATTGTGCG TGGAAATGAA GGTGTATTCA TTATGGGCAA AACCATTGAA 
TTTCACATGG GTGGTAATAT GGAGTTAAAG GCGGAAAACA GTATCATCCT AAATGGATCT 
GTGATGGTCA GCACCACCCG CCTACCCAGT TCCTCCAGTG GAGACCAGTT GGGTAGTGGT 
GACTGGGTAC GCTACAAGCT CTGCATGTGT GCTGATGGGA CGCTCTTCAA GGTGCAAGTA 
ACCAGCCAGA ACATGGGCTG CCAAATCTCA GACAACCCCT GTGGAAACAC TCATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SGCB ( NM_000232.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000223.1 Homo sapiens sarcoglycan beta (SGCB), mRNA.

Price & Availability↑

CloneID	OHu21735
Clone ID Related Accession (Same CDS sequence)	NM_000232.5 , NM_000232.4
Accession Version	NM_000232.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 957bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	beta-sarcoglycan
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CN483961.1, BC020709.1, AC093858.2, AK094731.1 and CA449352.1. This sequence is a reference standard in the RefSeqGene project. On Oct 17, 2008 this sequence version replaced NM_000232.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.225973.1, SRR1660807.221614.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCAG CGGCGGCGGC GGCTGCAGAA CAGCAAAGTT CCAATGGTCC TGTAAAGAAG 
TCCATGCGTG AGAAGGCTGT TGAGAGAAGG AGTGTCAATA AAGAGCACAA CAGTAACTTT 
AAAGCTGGAT ACATTCCGAT TGATGAAGAT CGTCTCCACA AAACAGGGTT GAGAGGAAGA 
AAGGGCAATT TAGCCATCTG TGTGATTATC CTCTTGTTTA TCCTGGCTGT CATCAATTTA 
ATAATAACAC TTGTTATTTG GGCCGTGATT CGCATTGGAC CAAATGGCTG TGATAGTATG 
GAGTTTCATG AAAGTGGCCT GCTTCGATTT AAGCAAGTAT CTGACATGGG AGTGATCCAC 
CCTCTTTATA AAAGCACAGT AGGAGGAAGG CGAAATGAAA ATTTGGTCAT CACTGGCAAC 
AACCAGCCTA TTGTTTTTCA GCAAGGGACA ACAAAGCTCA GTGTAGAAAA CAACAAAACT 
TCTATTACAA GTGACATCGG CATGCAGTTT TTTGACCCGA GGACTCAAAA TATCTTATTC 
AGCACAGACT ATGAAACTCA TGAGTTTCAT TTGCCAAGTG GAGTGAAAAG TTTGAATGTT 
CAAAAGGCAT CTACTGAAAG GATTACCAGC AATGCTACCA GTGATTTAAA TATAAAAGTT 
GATGGGCGTG CTATTGTGCG TGGAAATGAA GGTGTATTCA TTATGGGCAA AACCATTGAA 
TTTCACATGG GTGGTAATAT GGAGTTAAAG GCGGAAAACA GTATCATCCT AAATGGATCT 
GTGATGGTCA GCACCACCCG CCTACCCAGT TCCTCCAGTG GAGACCAGTT GGGTAGTGGT 
GACTGGGTAC GCTACAAGCT CTGCATGTGT GCTGATGGGA CGCTCTTCAA GGTGCAAGTA 
ACCAGCCAGA ACATGGGCTG CCAAATCTCA GACAACCCCT GTGGAAACAC TCATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000223.1
CDS	61..1017
Translation	MAAAAAAAAEQQSSNGPVKKSMREKAVERRSVNKEHNSNFKAGYIPIDEDRLHKTGLRGRKGNLAICVIILLFILAVINLIITLVIWAVIRIGPNGCDSMEFHESGLLRFKQVSDMGVIHPLYKSTVGGRRNENLVITGNNQPIVFQQGTTKLSVENNKTSITSDIGMQFFDPRTQNILFSTDYETHEFHLPSGVKSLNVQKASTERITSNATSDLNIKVDGRAIVRGNEGVFIMGKTIEFHMGGNMELKAENSIILNGSVMVSTTRLPSSSSGDQLGSGDWVRYKLCMCADGTLFKVQVTSQNMGCQISDNPCGNTH

Target ORF information:

RefSeq Version	NM_000232.4
Organism	Homo sapiens(human)
Definition	Homo sapiens sarcoglycan beta (SGCB), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000232.4

ORF Insert Sequence:

ATGGCGGCAG CGGCGGCGGC GGCTGCAGAA CAGCAAAGTT CCAATGGTCC TGTAAAGAAG 
TCCATGCGTG AGAAGGCTGT TGAGAGAAGG AGTGTCAATA AAGAGCACAA CAGTAACTTT 
AAAGCTGGAT ACATTCCGAT TGATGAAGAT CGTCTCCACA AAACAGGGTT GAGAGGAAGA 
AAGGGCAATT TAGCCATCTG TGTGATTATC CTCTTGTTTA TCCTGGCTGT CATCAATTTA 
ATAATAACAC TTGTTATTTG GGCCGTGATT CGCATTGGAC CAAATGGCTG TGATAGTATG 
GAGTTTCATG AAAGTGGCCT GCTTCGATTT AAGCAAGTAT CTGACATGGG AGTGATCCAC 
CCTCTTTATA AAAGCACAGT AGGAGGAAGG CGAAATGAAA ATTTGGTCAT CACTGGCAAC 
AACCAGCCTA TTGTTTTTCA GCAAGGGACA ACAAAGCTCA GTGTAGAAAA CAACAAAACT 
TCTATTACAA GTGACATCGG CATGCAGTTT TTTGACCCGA GGACTCAAAA TATCTTATTC 
AGCACAGACT ATGAAACTCA TGAGTTTCAT TTGCCAAGTG GAGTGAAAAG TTTGAATGTT 
CAAAAGGCAT CTACTGAAAG GATTACCAGC AATGCTACCA GTGATTTAAA TATAAAAGTT 
GATGGGCGTG CTATTGTGCG TGGAAATGAA GGTGTATTCA TTATGGGCAA AACCATTGAA 
TTTCACATGG GTGGTAATAT GGAGTTAAAG GCGGAAAACA GTATCATCCT AAATGGATCT 
GTGATGGTCA GCACCACCCG CCTACCCAGT TCCTCCAGTG GAGACCAGTT GGGTAGTGGT 
GACTGGGTAC GCTACAAGCT CTGCATGTGT GCTGATGGGA CGCTCTTCAA GGTGCAAGTA 
ACCAGCCAGA ACATGGGCTG CCAAATCTCA GACAACCCCT GTGGAAACAC TCATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

LGMD2E is the most common type of sarcoglycanopathies in the Iranian population.
Journal of neurogenetics31(3)161-169(2017 Sep)
Alavi A,Esmaeili S,Nilipour Y,Nafissi S,Tonekaboni SH,Zamani G,Ashrafi MR,Kahrizi K,Najmabadi H,Jazayeri F

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Clinical and genetic spectrum in limb-girdle muscular dystrophy type 2E.
Neurology84(17)1772-81(2015 Apr)
Semplicini C,Vissing J,Dahlqvist JR,Stojkovic T,Bello L,Witting N,Duno M,Leturcq F,Bertolin C,D'Ambrosio P,Eymard B,Angelini C,Politano L,Lafor?t P,Pegoraro E

Sarcoglycanopathies: can muscle immunoanalysis predict the genotype?
Neuromuscular disorders : NMD18(12)934-41(2008 Dec)
Klinge L,Dekomien G,Aboumousa A,Charlton R,Epplen JT,Barresi R,Bushby K,Straub V

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SGCB cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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