GREM2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GREM2
Entrez Gene ID	64388
Full Name	gremlin 2, DAN family BMP antagonist
Synonyms	CKTSF1B2,DAND3,PRDC,STHAG9
General protein information	Preferred Names gremlin 2, DAN family BMP antagonist Names gremlin-2 DAN domain family member 3 cysteine knot superfamily 1, BMP antagonist 2 gremlin 2, cysteine knot superfamily, homolog protein related to DAN and cerberus
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q43
Summary	This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. [provided by RefSeq, Jul 2008].
Disorder MIM:	608832
Disorder Html:	Tooth agenesis, selective, 9, 617275 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_005273226.3	XP_005273283.1	gremlin-2 isoform X1
NM_022469.3	NP_071914.3	gremlin-2 precursor
XM_011544249.1	XP_011542551.1	gremlin-2 isoform X1
XM_005273226.4	XP_005273283.1	gremlin-2 isoform X1
XM_011544249.2	XP_011542551.1	gremlin-2 isoform X2
NM_022469.4	NP_071914.3	gremlin-2 precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	GREM2	XP_005622630.1
Danio rerio (zebrafish)	grem2	NP_001017704.1
Pan troglodytes (chimpanzee)	GREM2	XP_525111.2
Rattus norvegicus (Norway rat)	Grem2	NP_001099444.1
Gallus gallus (chicken)	GREM2	XP_419552.3
Homo sapiens (human)	GREM2	NP_071914.3
	GREM2	XP_001095526.1
Mus musculus (house mouse)	Grem2	NP_035955.1

Gene Ontology
Bibliography

Related articles in PubMed

GREM2 nucleotide variants and the risk of tooth agenesis.
Mostowska A, Biedziak B, Zadurska M, Bogdanowicz A, Olszewska A, Cie?li?ska K, Firlej E, Jagodzi?ski PP
Oral diseases(2017 Oct)

Coordinated Proliferation and Differentiation of Human-Induced Pluripotent Stem Cell-Derived Cardiac Progenitor Cells Depend on Bone Morphogenetic Protein Signaling Regulation by GREMLIN 2.
Bylund JB, Trinh LT, Awgulewitsch CP, Paik DT, Jetter C, Jha R, Zhang J, Nolan K, Xu C, Thompson TB, Kamp TJ, Hatzopoulos AK
Stem cells and development26(9)678-693(2017 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that the GREMLIN 2 (GREM2) expression during Induced Pluripotent Stem Cell (hiPS) cell cardiac differentiation follows the expression pattern of cardiac-specific genes.
Title: Coordinated Proliferation and Differentiation of Human-Induced Pluripotent Stem Cell-Derived Cardiac Progenitor Cells Depend on Bone Morphogenetic Protein Signaling Regulation by GREMLIN 2.

The present study shows that the Grem2 heparin/HS and BMP2-binding epitopes are unique and independent, where the Grem2-BMP2 complex exhibits a significant increase in binding affinity toward heparin moieties that appear to be partially independent of the Grem2 heparin/HS-binding epitope.
Title: Analysis and identification of the Grem2 heparin/heparan sulfate-binding motif.

This study showed that si-Grem2 increased the BMP-2-induced osteogenic differentiation of hBMSCs via the BMP-2/Smad/Runx2 pathway.
Title: Gremlin2 Suppression Increases the BMP-2-Induced Osteogenesis of Human Bone Marrow-Derived Mesenchymal Stem Cells Via the BMP-2/Smad/Runx2 Signaling Pathway.

The structure of Grem2-GDF5 complex has revealed a number of key findings for DAN-family mediated BMP2 inhibition.
Title: Structure of Gremlin-2 in Complex with GDF5 Gives Insight into DAN-Family-Mediated BMP Antagonism.

mutations associated with tooth malformations
Title: GREMLIN 2 Mutations and Dental Anomalies.

The following GREM2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GREM2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29243	NM_022469.4 Latest version!	Homo sapiens gremlin 2, DAN family BMP antagonist (GREM2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu29243	XM_011544249.2 Latest version!	Homo sapiens gremlin 2, DAN family BMP antagonist (GREM2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu35074	XM_005273226.4 Latest version!	Homo sapiens gremlin 2, DAN family BMP antagonist (GREM2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu35074	XM_005273226.3	Homo sapiens gremlin 2, DAN family BMP antagonist (GREM2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu29243	XM_011544249.1	Homo sapiens gremlin 2, DAN family BMP antagonist (GREM2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu29243	NM_022469.3	Homo sapiens gremlin 2, DAN family BMP antagonist (GREM2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GREM2 ( NM_022469.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_071914.3 Homo sapiens gremlin 2, DAN family BMP antagonist (GREM2), mRNA.

Price & Availability↑

CloneID	OHu29243
Clone ID Related Accession (Same CDS sequence)	NM_022469.3 , XM_011544249.1 , XM_011544249.2 , NM_022469.4
Accession Version	NM_022469.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 507bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	gremlin-2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL358176.22, AK024848.1 and BQ005641.1. This sequence is a reference standard in the RefSeqGene project. On Jul 26, 2005 this sequence version replaced NM_022469.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.209525.1, SRR1660805.186279.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTCTGGA AGCTTTCCCT GTCCTTGTTC CTGGTGGCGG TGCTGGTGAA GGTGGCGGAA 
GCCCGGAAGA ACCGGCCGGC GGGCGCCATC CCCTCGCCTT ACAAGGACGG CAGCAGCAAC 
AACTCGGAGA GATGGCAGCA CCAGATCAAG GAGGTGCTGG CCTCCAGCCA GGAGGCCCTG 
GTGGTCACCG AGCGCAAGTA CCTCAAGAGT GACTGGTGCA AGACGCAGCC GCTGCGGCAG 
ACGGTGAGCG AGGAGGGCTG CCGGAGCCGC ACCATCCTCA ACCGCTTCTG CTACGGCCAG 
TGCAACTCCT TCTACATCCC GCGGCACGTG AAGAAGGAGG AGGAGTCCTT CCAGTCCTGC 
GCCTTCTGCA AGCCCCAGCG CGTCACCTCC GTCCTCGTGG AGCTCGAGTG CCCCGGCCTG 
GACCCACCCT TCCGACTCAA GAAAATCCAG AAGGTGAAGC AGTGCCGGTG CATGTCCGTG 
AACCTGAGCG ACTCGGACAA GCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071914.3
CDS	281..787
Translation	MFWKLSLSLFLVAVLVKVAEARKNRPAGAIPSPYKDGSSNNSERWQHQIKEVLASSQEALVVTERKYLKSDWCKTQPLRQTVSEEGCRSRTILNRFCYGQCNSFYIPRHVKKEEESFQSCAFCKPQRVTSVLVELECPGLDPPFRLKKIQKVKQCRCMSVNLSDSDKQ

Target ORF information:

RefSeq Version	NM_022469.3
Organism	Homo sapiens(human)
Definition	Homo sapiens gremlin 2, DAN family BMP antagonist (GREM2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022469.3

ORF Insert Sequence:

ATGTTCTGGA AGCTTTCCCT GTCCTTGTTC CTGGTGGCGG TGCTGGTGAA GGTGGCGGAA 
GCCCGGAAGA ACCGGCCGGC GGGCGCCATC CCCTCGCCTT ACAAGGACGG CAGCAGCAAC 
AACTCGGAGA GATGGCAGCA CCAGATCAAG GAGGTGCTGG CCTCCAGCCA GGAGGCCCTG 
GTGGTCACCG AGCGCAAGTA CCTCAAGAGT GACTGGTGCA AGACGCAGCC GCTGCGGCAG 
ACGGTGAGCG AGGAGGGCTG CCGGAGCCGC ACCATCCTCA ACCGCTTCTG CTACGGCCAG 
TGCAACTCCT TCTACATCCC GCGGCACGTG AAGAAGGAGG AGGAGTCCTT CCAGTCCTGC 
GCCTTCTGCA AGCCCCAGCG CGTCACCTCC GTCCTCGTGG AGCTCGAGTG CCCCGGCCTG 
GACCCACCCT TCCGACTCAA GAAAATCCAG AAGGTGAAGC AGTGCCGGTG CATGTCCGTG 
AACCTGAGCG ACTCGGACAA GCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GREM2 ( NM_022469.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_071914.3 Homo sapiens gremlin 2, DAN family BMP antagonist (GREM2), mRNA.

Price & Availability↑

CloneID	OHu29243
Clone ID Related Accession (Same CDS sequence)	NM_022469.3 , XM_011544249.1 , XM_011544249.2 , NM_022469.4
Accession Version	NM_022469.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 507bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	gremlin-2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL358176.22, AK024848.1 and BQ005641.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_022469.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.263944.1, SRR1660807.209525.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000318160.5/ ENSP00000318650.4 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTTCTGGA AGCTTTCCCT GTCCTTGTTC CTGGTGGCGG TGCTGGTGAA GGTGGCGGAA 
GCCCGGAAGA ACCGGCCGGC GGGCGCCATC CCCTCGCCTT ACAAGGACGG CAGCAGCAAC 
AACTCGGAGA GATGGCAGCA CCAGATCAAG GAGGTGCTGG CCTCCAGCCA GGAGGCCCTG 
GTGGTCACCG AGCGCAAGTA CCTCAAGAGT GACTGGTGCA AGACGCAGCC GCTGCGGCAG 
ACGGTGAGCG AGGAGGGCTG CCGGAGCCGC ACCATCCTCA ACCGCTTCTG CTACGGCCAG 
TGCAACTCCT TCTACATCCC GCGGCACGTG AAGAAGGAGG AGGAGTCCTT CCAGTCCTGC 
GCCTTCTGCA AGCCCCAGCG CGTCACCTCC GTCCTCGTGG AGCTCGAGTG CCCCGGCCTG 
GACCCACCCT TCCGACTCAA GAAAATCCAG AAGGTGAAGC AGTGCCGGTG CATGTCCGTG 
AACCTGAGCG ACTCGGACAA GCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071914.3
CDS	274..780
Translation	MFWKLSLSLFLVAVLVKVAEARKNRPAGAIPSPYKDGSSNNSERWQHQIKEVLASSQEALVVTERKYLKSDWCKTQPLRQTVSEEGCRSRTILNRFCYGQCNSFYIPRHVKKEEESFQSCAFCKPQRVTSVLVELECPGLDPPFRLKKIQKVKQCRCMSVNLSDSDKQ

Target ORF information:

RefSeq Version	NM_022469.4
Organism	Homo sapiens(human)
Definition	Homo sapiens gremlin 2, DAN family BMP antagonist (GREM2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022469.4

ORF Insert Sequence:

ATGTTCTGGA AGCTTTCCCT GTCCTTGTTC CTGGTGGCGG TGCTGGTGAA GGTGGCGGAA 
GCCCGGAAGA ACCGGCCGGC GGGCGCCATC CCCTCGCCTT ACAAGGACGG CAGCAGCAAC 
AACTCGGAGA GATGGCAGCA CCAGATCAAG GAGGTGCTGG CCTCCAGCCA GGAGGCCCTG 
GTGGTCACCG AGCGCAAGTA CCTCAAGAGT GACTGGTGCA AGACGCAGCC GCTGCGGCAG 
ACGGTGAGCG AGGAGGGCTG CCGGAGCCGC ACCATCCTCA ACCGCTTCTG CTACGGCCAG 
TGCAACTCCT TCTACATCCC GCGGCACGTG AAGAAGGAGG AGGAGTCCTT CCAGTCCTGC 
GCCTTCTGCA AGCCCCAGCG CGTCACCTCC GTCCTCGTGG AGCTCGAGTG CCCCGGCCTG 
GACCCACCCT TCCGACTCAA GAAAATCCAG AAGGTGAAGC AGTGCCGGTG CATGTCCGTG 
AACCTGAGCG ACTCGGACAA GCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GREM2 ( XM_011544249.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011542551.1 Homo sapiens gremlin 2, DAN family BMP antagonist (GREM2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu29243
Clone ID Related Accession (Same CDS sequence)	NM_022469.3 , XM_011544249.1 , XM_011544249.2 , NM_022469.4
Accession Version	XM_011544249.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 507bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	gremlin-2 isoform X1
Comment

ATGTTCTGGA AGCTTTCCCT GTCCTTGTTC CTGGTGGCGG TGCTGGTGAA GGTGGCGGAA 
GCCCGGAAGA ACCGGCCGGC GGGCGCCATC CCCTCGCCTT ACAAGGACGG CAGCAGCAAC 
AACTCGGAGA GATGGCAGCA CCAGATCAAG GAGGTGCTGG CCTCCAGCCA GGAGGCCCTG 
GTGGTCACCG AGCGCAAGTA CCTCAAGAGT GACTGGTGCA AGACGCAGCC GCTGCGGCAG 
ACGGTGAGCG AGGAGGGCTG CCGGAGCCGC ACCATCCTCA ACCGCTTCTG CTACGGCCAG 
TGCAACTCCT TCTACATCCC GCGGCACGTG AAGAAGGAGG AGGAGTCCTT CCAGTCCTGC 
GCCTTCTGCA AGCCCCAGCG CGTCACCTCC GTCCTCGTGG AGCTCGAGTG CCCCGGCCTG 
GACCCACCCT TCCGACTCAA GAAAATCCAG AAGGTGAAGC AGTGCCGGTG CATGTCCGTG 
AACCTGAGCG ACTCGGACAA GCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011542551.1
Translation	MFWKLSLSLFLVAVLVKVAEARKNRPAGAIPSPYKDGSSNNSERWQHQIKEVLASSQEALVVTERKYLKSDWCKTQPLRQTVSEEGCRSRTILNRFCYGQCNSFYIPRHVKKEEESFQSCAFCKPQRVTSVLVELECPGLDPPFRLKKIQKVKQCRCMSVNLSDSDKQ

Target ORF information:

RefSeq Version	XM_011544249.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens gremlin 2, DAN family BMP antagonist (GREM2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011544249.1

ORF Insert Sequence:

ATGTTCTGGA AGCTTTCCCT GTCCTTGTTC CTGGTGGCGG TGCTGGTGAA GGTGGCGGAA 
GCCCGGAAGA ACCGGCCGGC GGGCGCCATC CCCTCGCCTT ACAAGGACGG CAGCAGCAAC 
AACTCGGAGA GATGGCAGCA CCAGATCAAG GAGGTGCTGG CCTCCAGCCA GGAGGCCCTG 
GTGGTCACCG AGCGCAAGTA CCTCAAGAGT GACTGGTGCA AGACGCAGCC GCTGCGGCAG 
ACGGTGAGCG AGGAGGGCTG CCGGAGCCGC ACCATCCTCA ACCGCTTCTG CTACGGCCAG 
TGCAACTCCT TCTACATCCC GCGGCACGTG AAGAAGGAGG AGGAGTCCTT CCAGTCCTGC 
GCCTTCTGCA AGCCCCAGCG CGTCACCTCC GTCCTCGTGG AGCTCGAGTG CCCCGGCCTG 
GACCCACCCT TCCGACTCAA GAAAATCCAG AAGGTGAAGC AGTGCCGGTG CATGTCCGTG 
AACCTGAGCG ACTCGGACAA GCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GREM2 ( XM_011544249.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011542551.1 Homo sapiens gremlin 2, DAN family BMP antagonist (GREM2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu29243
Clone ID Related Accession (Same CDS sequence)	NM_022469.3 , XM_011544249.1 , XM_011544249.2 , NM_022469.4
Accession Version	XM_011544249.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 507bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	gremlin-2 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011544249.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTCTGGA AGCTTTCCCT GTCCTTGTTC CTGGTGGCGG TGCTGGTGAA GGTGGCGGAA 
GCCCGGAAGA ACCGGCCGGC GGGCGCCATC CCCTCGCCTT ACAAGGACGG CAGCAGCAAC 
AACTCGGAGA GATGGCAGCA CCAGATCAAG GAGGTGCTGG CCTCCAGCCA GGAGGCCCTG 
GTGGTCACCG AGCGCAAGTA CCTCAAGAGT GACTGGTGCA AGACGCAGCC GCTGCGGCAG 
ACGGTGAGCG AGGAGGGCTG CCGGAGCCGC ACCATCCTCA ACCGCTTCTG CTACGGCCAG 
TGCAACTCCT TCTACATCCC GCGGCACGTG AAGAAGGAGG AGGAGTCCTT CCAGTCCTGC 
GCCTTCTGCA AGCCCCAGCG CGTCACCTCC GTCCTCGTGG AGCTCGAGTG CCCCGGCCTG 
GACCCACCCT TCCGACTCAA GAAAATCCAG AAGGTGAAGC AGTGCCGGTG CATGTCCGTG 
AACCTGAGCG ACTCGGACAA GCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011542551.1
CDS	611..1117
Translation	MFWKLSLSLFLVAVLVKVAEARKNRPAGAIPSPYKDGSSNNSERWQHQIKEVLASSQEALVVTERKYLKSDWCKTQPLRQTVSEEGCRSRTILNRFCYGQCNSFYIPRHVKKEEESFQSCAFCKPQRVTSVLVELECPGLDPPFRLKKIQKVKQCRCMSVNLSDSDKQ

Target ORF information:

RefSeq Version	XM_011544249.2
Organism	Homo sapiens(human)
Definition	Homo sapiens gremlin 2, DAN family BMP antagonist (GREM2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011544249.2

ORF Insert Sequence:

ATGTTCTGGA AGCTTTCCCT GTCCTTGTTC CTGGTGGCGG TGCTGGTGAA GGTGGCGGAA 
GCCCGGAAGA ACCGGCCGGC GGGCGCCATC CCCTCGCCTT ACAAGGACGG CAGCAGCAAC 
AACTCGGAGA GATGGCAGCA CCAGATCAAG GAGGTGCTGG CCTCCAGCCA GGAGGCCCTG 
GTGGTCACCG AGCGCAAGTA CCTCAAGAGT GACTGGTGCA AGACGCAGCC GCTGCGGCAG 
ACGGTGAGCG AGGAGGGCTG CCGGAGCCGC ACCATCCTCA ACCGCTTCTG CTACGGCCAG 
TGCAACTCCT TCTACATCCC GCGGCACGTG AAGAAGGAGG AGGAGTCCTT CCAGTCCTGC 
GCCTTCTGCA AGCCCCAGCG CGTCACCTCC GTCCTCGTGG AGCTCGAGTG CCCCGGCCTG 
GACCCACCCT TCCGACTCAA GAAAATCCAG AAGGTGAAGC AGTGCCGGTG CATGTCCGTG 
AACCTGAGCG ACTCGGACAA GCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GREM2 ( XM_005273226.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005273283.1 Homo sapiens gremlin 2, DAN family BMP antagonist (GREM2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu35074
Clone ID Related Accession (Same CDS sequence)	XM_005273226.3 , XM_005273226.4
Accession Version	XM_005273226.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 561bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	gremlin-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005273226.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGAGCAC TCAGAGCTGA GTCCACGTCA GGGAGCAGGC AGACGCCTTG CAGGATGTTC 
TGGAAGCTTT CCCTGTCCTT GTTCCTGGTG GCGGTGCTGG TGAAGGTGGC GGAAGCCCGG 
AAGAACCGGC CGGCGGGCGC CATCCCCTCG CCTTACAAGG ACGGCAGCAG CAACAACTCG 
GAGAGATGGC AGCACCAGAT CAAGGAGGTG CTGGCCTCCA GCCAGGAGGC CCTGGTGGTC 
ACCGAGCGCA AGTACCTCAA GAGTGACTGG TGCAAGACGC AGCCGCTGCG GCAGACGGTG 
AGCGAGGAGG GCTGCCGGAG CCGCACCATC CTCAACCGCT TCTGCTACGG CCAGTGCAAC 
TCCTTCTACA TCCCGCGGCA CGTGAAGAAG GAGGAGGAGT CCTTCCAGTC CTGCGCCTTC 
TGCAAGCCCC AGCGCGTCAC CTCCGTCCTC GTGGAGCTCG AGTGCCCCGG CCTGGACCCA 
CCCTTCCGAC TCAAGAAAAT CCAGAAGGTG AAGCAGTGCC GGTGCATGTC CGTGAACCTG 
AGCGACTCGG ACAAGCAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005273283.1
CDS	55..615
Translation	MRALRAESTSGSRQTPCRMFWKLSLSLFLVAVLVKVAEARKNRPAGAIPSPYKDGSSNNSERWQHQIKEVLASSQEALVVTERKYLKSDWCKTQPLRQTVSEEGCRSRTILNRFCYGQCNSFYIPRHVKKEEESFQSCAFCKPQRVTSVLVELECPGLDPPFRLKKIQKVKQCRCMSVNLSDSDKQ

Target ORF information:

RefSeq Version	XM_005273226.3
Organism	Homo sapiens(human)
Definition	Homo sapiens gremlin 2, DAN family BMP antagonist (GREM2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005273226.3

ORF Insert Sequence:

ATGAGAGCAC TCAGAGCTGA GTCCACGTCA GGGAGCAGGC AGACGCCTTG CAGGATGTTC 
TGGAAGCTTT CCCTGTCCTT GTTCCTGGTG GCGGTGCTGG TGAAGGTGGC GGAAGCCCGG 
AAGAACCGGC CGGCGGGCGC CATCCCCTCG CCTTACAAGG ACGGCAGCAG CAACAACTCG 
GAGAGATGGC AGCACCAGAT CAAGGAGGTG CTGGCCTCCA GCCAGGAGGC CCTGGTGGTC 
ACCGAGCGCA AGTACCTCAA GAGTGACTGG TGCAAGACGC AGCCGCTGCG GCAGACGGTG 
AGCGAGGAGG GCTGCCGGAG CCGCACCATC CTCAACCGCT TCTGCTACGG CCAGTGCAAC 
TCCTTCTACA TCCCGCGGCA CGTGAAGAAG GAGGAGGAGT CCTTCCAGTC CTGCGCCTTC 
TGCAAGCCCC AGCGCGTCAC CTCCGTCCTC GTGGAGCTCG AGTGCCCCGG CCTGGACCCA 
CCCTTCCGAC TCAAGAAAAT CCAGAAGGTG AAGCAGTGCC GGTGCATGTC CGTGAACCTG 
AGCGACTCGG ACAAGCAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GREM2 ( XM_005273226.4 ) cDNA ORF clone, Homo sapiens(human) -> XP_005273283.1 Homo sapiens gremlin 2, DAN family BMP antagonist (GREM2), transcript variant X1, mRNA.

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CloneID	OHu35074
Clone ID Related Accession (Same CDS sequence)	XM_005273226.3 , XM_005273226.4
Accession Version	XM_005273226.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 561bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	gremlin-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_005273226.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGAGCAC TCAGAGCTGA GTCCACGTCA GGGAGCAGGC AGACGCCTTG CAGGATGTTC 
TGGAAGCTTT CCCTGTCCTT GTTCCTGGTG GCGGTGCTGG TGAAGGTGGC GGAAGCCCGG 
AAGAACCGGC CGGCGGGCGC CATCCCCTCG CCTTACAAGG ACGGCAGCAG CAACAACTCG 
GAGAGATGGC AGCACCAGAT CAAGGAGGTG CTGGCCTCCA GCCAGGAGGC CCTGGTGGTC 
ACCGAGCGCA AGTACCTCAA GAGTGACTGG TGCAAGACGC AGCCGCTGCG GCAGACGGTG 
AGCGAGGAGG GCTGCCGGAG CCGCACCATC CTCAACCGCT TCTGCTACGG CCAGTGCAAC 
TCCTTCTACA TCCCGCGGCA CGTGAAGAAG GAGGAGGAGT CCTTCCAGTC CTGCGCCTTC 
TGCAAGCCCC AGCGCGTCAC CTCCGTCCTC GTGGAGCTCG AGTGCCCCGG CCTGGACCCA 
CCCTTCCGAC TCAAGAAAAT CCAGAAGGTG AAGCAGTGCC GGTGCATGTC CGTGAACCTG 
AGCGACTCGG ACAAGCAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005273283.1
CDS	71..631
Translation	MRALRAESTSGSRQTPCRMFWKLSLSLFLVAVLVKVAEARKNRPAGAIPSPYKDGSSNNSERWQHQIKEVLASSQEALVVTERKYLKSDWCKTQPLRQTVSEEGCRSRTILNRFCYGQCNSFYIPRHVKKEEESFQSCAFCKPQRVTSVLVELECPGLDPPFRLKKIQKVKQCRCMSVNLSDSDKQ

Target ORF information:

RefSeq Version	XM_005273226.4
Organism	Homo sapiens(human)
Definition	Homo sapiens gremlin 2, DAN family BMP antagonist (GREM2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005273226.4

ORF Insert Sequence:

ATGAGAGCAC TCAGAGCTGA GTCCACGTCA GGGAGCAGGC AGACGCCTTG CAGGATGTTC 
TGGAAGCTTT CCCTGTCCTT GTTCCTGGTG GCGGTGCTGG TGAAGGTGGC GGAAGCCCGG 
AAGAACCGGC CGGCGGGCGC CATCCCCTCG CCTTACAAGG ACGGCAGCAG CAACAACTCG 
GAGAGATGGC AGCACCAGAT CAAGGAGGTG CTGGCCTCCA GCCAGGAGGC CCTGGTGGTC 
ACCGAGCGCA AGTACCTCAA GAGTGACTGG TGCAAGACGC AGCCGCTGCG GCAGACGGTG 
AGCGAGGAGG GCTGCCGGAG CCGCACCATC CTCAACCGCT TCTGCTACGG CCAGTGCAAC 
TCCTTCTACA TCCCGCGGCA CGTGAAGAAG GAGGAGGAGT CCTTCCAGTC CTGCGCCTTC 
TGCAAGCCCC AGCGCGTCAC CTCCGTCCTC GTGGAGCTCG AGTGCCCCGG CCTGGACCCA 
CCCTTCCGAC TCAAGAAAAT CCAGAAGGTG AAGCAGTGCC GGTGCATGTC CGTGAACCTG 
AGCGACTCGG ACAAGCAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

GREM2 nucleotide variants and the risk of tooth agenesis.
Oral diseases(2017 Oct)
Mostowska A,Biedziak B,Zadurska M,Bogdanowicz A,Olszewska A,Cie?li?ska K,Firlej E,Jagodzi?ski PP

Coordinated Proliferation and Differentiation of Human-Induced Pluripotent Stem Cell-Derived Cardiac Progenitor Cells Depend on Bone Morphogenetic Protein Signaling Regulation by GREMLIN 2.
Stem cells and development26(9)678-693(2017 May)
Bylund JB,Trinh LT,Awgulewitsch CP,Paik DT,Jetter C,Jha R,Zhang J,Nolan K,Xu C,Thompson TB,Kamp TJ,Hatzopoulos AK

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GREM2 cDNA ORF clone, Homo sapiens(human)

Gene

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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