SELENOP cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SELENOP
Entrez Gene ID	6414
Full Name	selenoprotein P
Synonyms	SELP,SEPP,SEPP1,SeP
General protein information	Preferred Names selenoprotein P Names selenoprotein P selenoprotein P, plasma, 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5p12
Summary	This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (10 in human), and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction, suggesting its importance in normal brain function. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The mRNA for this selenoprotein contains two SECIS elements. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2017].
Disorder MIM:	601484

mRNA and Protein(s)

mRNA	Protein	Name
NM_001093726.2	NP_001087195.1	selenoprotein P isoform 2
NM_001085486.1	NP_001078955.1	selenoprotein P isoform 1 precursor
NM_001085486.2	NP_001078955.1	selenoprotein P isoform 1 precursor
NM_005410.4	NP_005401.3	selenoprotein P isoform 1 precursor
NM_005410.2	NP_005401.3	selenoprotein P isoform 1 precursor
NM_005410.3	NP_005401.3	selenoprotein P isoform 1 precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Sepp1	NP_001036078.1
Rattus norvegicus (Norway rat)	Sepp1	NP_001077380.1
Homo sapiens (human)	SEPP1	NP_005401.3
Gallus gallus (chicken)	SEPP1	NP_001026780.2
Bos taurus (cattle)	SEPP1	NP_776884.2
	SEPP1	NP_001152962.1
Canis lupus familiaris (dog)	SEPP1	NP_001108590.1
Danio rerio (zebrafish)	sepp1a	NP_840082.2
Pan troglodytes (chimpanzee)	SEPP1	NP_001108587.1
Xenopus tropicalis (tropical clawed frog)	sepp1	NP_001186813.1

Gene Ontology
Bibliography

Related articles in PubMed

Multiple RNA structures affect translation initiation and UGA redefinition efficiency during synthesis of selenoprotein P.
Mariotti M, Shetty S, Baird L, Wu S, Loughran G, Copeland PR, Atkins JF, Howard MT
Nucleic acids research45(22)13004-13015(2017 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results indicate a diversity of RNA elements conducting multiple occurrences of UGA redefinition to control the synthesis of full-length and truncated selenoprotein P (SELENOP) isoforms.
Title: Multiple RNA structures affect translation initiation and UGA redefinition efficiency during synthesis of selenoprotein P.

Results indicate that the 2 genetic variants of rs7579 and rs230813 in SEPP1 may not play a role in the pathogenesis of preeclampsia in Chinese Han Women.
Title: Identification of SEPP1 polymorphisms is not a genetic risk factor for preeclampsia in Chinese Han women: A clinical trial and experimental study.

erum microRNA-7 and selenoprotein P appear to be potential non-invasive diagnostic markers for hepatocellular carcinoma. Moreover, the results suggest that selenium could be used as an anticancer therapy for hepatocellular carcinoma by affecting both microRNA-7 and selenoprotein P
Title: Role of microRNA-7 and selenoprotein P in hepatocellular carcinoma.

Increased amounts of circulating SeP predicted the ineffectiveness of training on endurance capacity in humans.
Title: Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of reactive oxygen species and AMP-activated protein kinase in muscle.

Biomarkers of Se status in clinical research need to be measured by validated assays in order to avoid erroneous data and incorrect interpretations, especially when analyzing young women. The Se content of circulating SELENOP differs between individuals and may provide some important diagnostic information on Se metabolism and status
Title: Sex-specific and inter-individual differences in biomarkers of selenium status identified by a calibrated ELISA for selenoprotein P.

The following SELENOP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SELENOP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13285	NM_001085486.2 Latest version!	Homo sapiens selenoprotein P (SELENOP), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu13285	NM_005410.4 Latest version!	Homo sapiens selenoprotein P (SELENOP), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu13421	NM_001093726.2 Latest version!	Homo sapiens selenoprotein P (SELENOP), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
View Old Accession Versions >>
OHu13285	NM_001085486.1	Homo sapiens selenoprotein P, plasma, 1 (SEPP1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu13285	NM_005410.2	Homo sapiens selenoprotein P, plasma, 1 (SEPP1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu13285	NM_005410.3	Homo sapiens selenoprotein P (SELENOP), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SELENOP ( NM_001085486.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001078955.1 Homo sapiens selenoprotein P, plasma, 1 (SEPP1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu13285
Clone ID Related Accession (Same CDS sequence)	NM_001085486.1 , NM_001085486.2 , NM_005410.4 , NM_005410.2 , NM_005410.3
Accession Version	NM_001085486.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1146bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-07-09
Organism	Homo sapiens(Human)
Product	selenoprotein P isoform 1 precursor
Comment

ATGTGGAGAA GCCTGGGGCT TGCCCTGGCT CTCTGTCTCC TCCCATCGGG AGGAACAGAG 
AGCCAGGACC AAAGCTCCTT ATGTAAGCAA CCCCCAGCCT GGAGCATAAG AGATCAAGAT 
CCAATGCTAA ACTCCAATGG TTCAGTGACT GTGGTTGCTC TTCTTCAAGC CAGCTGATAC 
CTGTGCATAC TGCAGGCATC TAAATTAGAA GACCTGCGAG TAAAACTGAA GAAAGAAGGA 
TATTCTAATA TTTCTTATAT TGTTGTTAAT CATCAAGGAA TCTCTTCTCG ATTAAAATAC 
ACACATCTTA AGAATAAGGT TTCAGAGCAT ATTCCTGTTT ATCAACAAGA AGAAAACCAA 
ACAGATGTCT GGACTCTTTT AAATGGAAGC AAAGATGACT TCCTCATATA TGATAGATGT 
GGCCGTCTTG TATATCATCT TGGTTTGCCT TTTTCCTTCC TAACTTTCCC ATATGTAGAA 
GAAGCCATTA AGATTGCTTA CTGTGAAAAG AAATGTGGAA ACTGCTCTCT CACGACTCTC 
AAAGATGAAG ACTTTTGTAA ACGTGTATCT TTGGCTACTG TGGATAAAAC AGTTGAAACT 
CCATCGCCTC ATTACCATCA TGAGCATCAT CACAATCATG GACATCAGCA CCTTGGCAGC 
AGTGAGCTTT CAGAGAATCA GCAACCAGGA GCACCAAATG CTCCTACTCA TCCTGCTCCT 
CCAGGCCTTC ATCACCACCA TAAGCACAAG GGTCAGCATA GGCAGGGTCA CCCAGAGAAC 
CGAGATATGC CAGCAAGTGA AGATTTACAA GATTTACAAA AGAAGCTCTG TCGAAAGAGA 
TGTATAAATC AATTACTCTG TAAATTGCCC ACAGATTCAG AGTTGGCTCC TAGGAGCTGA 
TGCTGCCATT GTCGACATCT GATATTTGAA AAAACAGGGT CTGCAATCAC CTGACAGTGT 
AAAGAAAACC TCCCATCTTT ATGTAGCTGA CAGGGACTTC GGGCAGAGGA GAACATAACT 
GAATCTTGTC AGTGACGTTT GCCTCCAGCT GCCTGACAAA TAAGTCAGCA GCTTATACCC 
ACAGAAGCCA GTGCCAGTTG ACGCTGAAAG AATCAGGCAA AAAAGTGAGA ATGACCTTCA 
AACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001078955.1
Translation	MWRSLGLALALCLLPSGGTESQDQSSLCKQPPAWSIRDQDPMLNSNGSVTVVALLQASYLCILQASKLEDLRVKLKKEGYSNISYIVVNHQGISSRLKYTHLKNKVSEHIPVYQQEENQTDVWTLLNGSKDDFLIYDRCGRLVYHLGLPFSFLTFPYVEEAIKIAYCEKKCGNCSLTTLKDEDFCKRVSLATVDKTVETPSPHYHHEHHHNHGHQHLGSSELSENQQPGAPNAPTHPAPPGLHHHHKHKGQHRQGHPENRDMPASEDLQDLQKKLCRKRCINQLLCKLPTDSELAPRSCCHCRHLIFEKTGSAITQCKENLPSLCSQGLRAEENITESCQRLPPAAQISQQLIPTEASASRKNQAKKEPSN

Target ORF information:

RefSeq Version	NM_001085486.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens selenoprotein P, plasma, 1 (SEPP1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001085486.1

ORF Insert Sequence:

ATGTGGAGAA GCCTGGGGCT TGCCCTGGCT CTCTGTCTCC TCCCATCGGG AGGAACAGAG 
AGCCAGGACC AAAGCTCCTT ATGTAAGCAA CCCCCAGCCT GGAGCATAAG AGATCAAGAT 
CCAATGCTAA ACTCCAATGG TTCAGTGACT GTGGTTGCTC TTCTTCAAGC CAGCTGATAC 
CTGTGCATAC TGCAGGCATC TAAATTAGAA GACCTGCGAG TAAAACTGAA GAAAGAAGGA 
TATTCTAATA TTTCTTATAT TGTTGTTAAT CATCAAGGAA TCTCTTCTCG ATTAAAATAC 
ACACATCTTA AGAATAAGGT TTCAGAGCAT ATTCCTGTTT ATCAACAAGA AGAAAACCAA 
ACAGATGTCT GGACTCTTTT AAATGGAAGC AAAGATGACT TCCTCATATA TGATAGATGT 
GGCCGTCTTG TATATCATCT TGGTTTGCCT TTTTCCTTCC TAACTTTCCC ATATGTAGAA 
GAAGCCATTA AGATTGCTTA CTGTGAAAAG AAATGTGGAA ACTGCTCTCT CACGACTCTC 
AAAGATGAAG ACTTTTGTAA ACGTGTATCT TTGGCTACTG TGGATAAAAC AGTTGAAACT 
CCATCGCCTC ATTACCATCA TGAGCATCAT CACAATCATG GACATCAGCA CCTTGGCAGC 
AGTGAGCTTT CAGAGAATCA GCAACCAGGA GCACCAAATG CTCCTACTCA TCCTGCTCCT 
CCAGGCCTTC ATCACCACCA TAAGCACAAG GGTCAGCATA GGCAGGGTCA CCCAGAGAAC 
CGAGATATGC CAGCAAGTGA AGATTTACAA GATTTACAAA AGAAGCTCTG TCGAAAGAGA 
TGTATAAATC AATTACTCTG TAAATTGCCC ACAGATTCAG AGTTGGCTCC TAGGAGCTGA 
TGCTGCCATT GTCGACATCT GATATTTGAA AAAACAGGGT CTGCAATCAC CTGACAGTGT 
AAAGAAAACC TCCCATCTTT ATGTAGCTGA CAGGGACTTC GGGCAGAGGA GAACATAACT 
GAATCTTGTC AGTGACGTTT GCCTCCAGCT GCCTGACAAA TAAGTCAGCA GCTTATACCC 
ACAGAAGCCA GTGCCAGTTG ACGCTGAAAG AATCAGGCAA AAAAGTGAGA ATGACCTTCA 
AACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SELENOP ( NM_001085486.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001078955.1 Homo sapiens selenoprotein P (SELENOP), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu13285
Clone ID Related Accession (Same CDS sequence)	NM_001085486.1 , NM_001085486.2 , NM_005410.4 , NM_005410.2 , NM_005410.3
Accession Version	NM_001085486.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1146bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-15
Organism	Homo sapiens(human)
Product	selenoprotein P isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA288385.1 and HM005482.1. On Feb 9, 2017 this sequence version replaced NM_001085486.1. Transcript Variant: This variant (2, also known as Sepp1c) contains an additional 5' non-coding exon, and thus has a different and longer 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: HM005482.1, ERR279838.79.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: PMID: 8421687 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTGGAGAA GCCTGGGGCT TGCCCTGGCT CTCTGTCTCC TCCCATCGGG AGGAACAGAG 
AGCCAGGACC AAAGCTCCTT ATGTAAGCAA CCCCCAGCCT GGAGCATAAG AGATCAAGAT 
CCAATGCTAA ACTCCAATGG TTCAGTGACT GTGGTTGCTC TTCTTCAAGC CAGCTGATAC 
CTGTGCATAC TGCAGGCATC TAAATTAGAA GACCTGCGAG TAAAACTGAA GAAAGAAGGA 
TATTCTAATA TTTCTTATAT TGTTGTTAAT CATCAAGGAA TCTCTTCTCG ATTAAAATAC 
ACACATCTTA AGAATAAGGT TTCAGAGCAT ATTCCTGTTT ATCAACAAGA AGAAAACCAA 
ACAGATGTCT GGACTCTTTT AAATGGAAGC AAAGATGACT TCCTCATATA TGATAGATGT 
GGCCGTCTTG TATATCATCT TGGTTTGCCT TTTTCCTTCC TAACTTTCCC ATATGTAGAA 
GAAGCCATTA AGATTGCTTA CTGTGAAAAG AAATGTGGAA ACTGCTCTCT CACGACTCTC 
AAAGATGAAG ACTTTTGTAA ACGTGTATCT TTGGCTACTG TGGATAAAAC AGTTGAAACT 
CCATCGCCTC ATTACCATCA TGAGCATCAT CACAATCATG GACATCAGCA CCTTGGCAGC 
AGTGAGCTTT CAGAGAATCA GCAACCAGGA GCACCAAATG CTCCTACTCA TCCTGCTCCT 
CCAGGCCTTC ATCACCACCA TAAGCACAAG GGTCAGCATA GGCAGGGTCA CCCAGAGAAC 
CGAGATATGC CAGCAAGTGA AGATTTACAA GATTTACAAA AGAAGCTCTG TCGAAAGAGA 
TGTATAAATC AATTACTCTG TAAATTGCCC ACAGATTCAG AGTTGGCTCC TAGGAGCTGA 
TGCTGCCATT GTCGACATCT GATATTTGAA AAAACAGGGT CTGCAATCAC CTGACAGTGT 
AAAGAAAACC TCCCATCTTT ATGTAGCTGA CAGGGACTTC GGGCAGAGGA GAACATAACT 
GAATCTTGTC AGTGACGTTT GCCTCCAGCT GCCTGACAAA TAAGTCAGCA GCTTATACCC 
ACAGAAGCCA GTGCCAGTTG ACGCTGAAAG AATCAGGCAA AAAAGTGAGA ATGACCTTCA 
AACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001078955.1
CDS	284..1429
Translation	MWRSLGLALALCLLPSGGTESQDQSSLCKQPPAWSIRDQDPMLNSNGSVTVVALLQASYLCILQASKLEDLRVKLKKEGYSNISYIVVNHQGISSRLKYTHLKNKVSEHIPVYQQEENQTDVWTLLNGSKDDFLIYDRCGRLVYHLGLPFSFLTFPYVEEAIKIAYCEKKCGNCSLTTLKDEDFCKRVSLATVDKTVETPSPHYHHEHHHNHGHQHLGSSELSENQQPGAPNAPTHPAPPGLHHHHKHKGQHRQGHPENRDMPASEDLQDLQKKLCRKRCINQLLCKLPTDSELAPRSCCHCRHLIFEKTGSAITQCKENLPSLCSQGLRAEENITESCQRLPPAAQISQQLIPTEASASRKNQAKKEPSN

Target ORF information:

RefSeq Version	NM_001085486.2
Organism	Homo sapiens(human)
Definition	Homo sapiens selenoprotein P (SELENOP), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001085486.2

ORF Insert Sequence:

ATGTGGAGAA GCCTGGGGCT TGCCCTGGCT CTCTGTCTCC TCCCATCGGG AGGAACAGAG 
AGCCAGGACC AAAGCTCCTT ATGTAAGCAA CCCCCAGCCT GGAGCATAAG AGATCAAGAT 
CCAATGCTAA ACTCCAATGG TTCAGTGACT GTGGTTGCTC TTCTTCAAGC CAGCTGATAC 
CTGTGCATAC TGCAGGCATC TAAATTAGAA GACCTGCGAG TAAAACTGAA GAAAGAAGGA 
TATTCTAATA TTTCTTATAT TGTTGTTAAT CATCAAGGAA TCTCTTCTCG ATTAAAATAC 
ACACATCTTA AGAATAAGGT TTCAGAGCAT ATTCCTGTTT ATCAACAAGA AGAAAACCAA 
ACAGATGTCT GGACTCTTTT AAATGGAAGC AAAGATGACT TCCTCATATA TGATAGATGT 
GGCCGTCTTG TATATCATCT TGGTTTGCCT TTTTCCTTCC TAACTTTCCC ATATGTAGAA 
GAAGCCATTA AGATTGCTTA CTGTGAAAAG AAATGTGGAA ACTGCTCTCT CACGACTCTC 
AAAGATGAAG ACTTTTGTAA ACGTGTATCT TTGGCTACTG TGGATAAAAC AGTTGAAACT 
CCATCGCCTC ATTACCATCA TGAGCATCAT CACAATCATG GACATCAGCA CCTTGGCAGC 
AGTGAGCTTT CAGAGAATCA GCAACCAGGA GCACCAAATG CTCCTACTCA TCCTGCTCCT 
CCAGGCCTTC ATCACCACCA TAAGCACAAG GGTCAGCATA GGCAGGGTCA CCCAGAGAAC 
CGAGATATGC CAGCAAGTGA AGATTTACAA GATTTACAAA AGAAGCTCTG TCGAAAGAGA 
TGTATAAATC AATTACTCTG TAAATTGCCC ACAGATTCAG AGTTGGCTCC TAGGAGCTGA 
TGCTGCCATT GTCGACATCT GATATTTGAA AAAACAGGGT CTGCAATCAC CTGACAGTGT 
AAAGAAAACC TCCCATCTTT ATGTAGCTGA CAGGGACTTC GGGCAGAGGA GAACATAACT 
GAATCTTGTC AGTGACGTTT GCCTCCAGCT GCCTGACAAA TAAGTCAGCA GCTTATACCC 
ACAGAAGCCA GTGCCAGTTG ACGCTGAAAG AATCAGGCAA AAAAGTGAGA ATGACCTTCA 
AACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SELENOP ( NM_005410.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005401.3 Homo sapiens selenoprotein P (SELENOP), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu13285
Clone ID Related Accession (Same CDS sequence)	NM_001085486.1 , NM_001085486.2 , NM_005410.4 , NM_005410.2 , NM_005410.3
Accession Version	NM_005410.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1146bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-15
Organism	Homo sapiens(human)
Product	selenoprotein P isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA288385.1, BC040075.1 and HM005482.1. On Nov 22, 2018 this sequence version replaced NM_005410.3. Transcript Variant: This variant (1, also known as Sepp1a) represents the predominant transcript and encodes isoform 1. Variants 1 and 2 encode the same isoform. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AL833145.1, SRR1660809.204172.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000514985.6/ ENSP00000420939.1 protein contains selenocysteine :: PMID: 8421687 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTGGAGAA GCCTGGGGCT TGCCCTGGCT CTCTGTCTCC TCCCATCGGG AGGAACAGAG 
AGCCAGGACC AAAGCTCCTT ATGTAAGCAA CCCCCAGCCT GGAGCATAAG AGATCAAGAT 
CCAATGCTAA ACTCCAATGG TTCAGTGACT GTGGTTGCTC TTCTTCAAGC CAGCTGATAC 
CTGTGCATAC TGCAGGCATC TAAATTAGAA GACCTGCGAG TAAAACTGAA GAAAGAAGGA 
TATTCTAATA TTTCTTATAT TGTTGTTAAT CATCAAGGAA TCTCTTCTCG ATTAAAATAC 
ACACATCTTA AGAATAAGGT TTCAGAGCAT ATTCCTGTTT ATCAACAAGA AGAAAACCAA 
ACAGATGTCT GGACTCTTTT AAATGGAAGC AAAGATGACT TCCTCATATA TGATAGATGT 
GGCCGTCTTG TATATCATCT TGGTTTGCCT TTTTCCTTCC TAACTTTCCC ATATGTAGAA 
GAAGCCATTA AGATTGCTTA CTGTGAAAAG AAATGTGGAA ACTGCTCTCT CACGACTCTC 
AAAGATGAAG ACTTTTGTAA ACGTGTATCT TTGGCTACTG TGGATAAAAC AGTTGAAACT 
CCATCGCCTC ATTACCATCA TGAGCATCAT CACAATCATG GACATCAGCA CCTTGGCAGC 
AGTGAGCTTT CAGAGAATCA GCAACCAGGA GCACCAAATG CTCCTACTCA TCCTGCTCCT 
CCAGGCCTTC ATCACCACCA TAAGCACAAG GGTCAGCATA GGCAGGGTCA CCCAGAGAAC 
CGAGATATGC CAGCAAGTGA AGATTTACAA GATTTACAAA AGAAGCTCTG TCGAAAGAGA 
TGTATAAATC AATTACTCTG TAAATTGCCC ACAGATTCAG AGTTGGCTCC TAGGAGCTGA 
TGCTGCCATT GTCGACATCT GATATTTGAA AAAACAGGGT CTGCAATCAC CTGACAGTGT 
AAAGAAAACC TCCCATCTTT ATGTAGCTGA CAGGGACTTC GGGCAGAGGA GAACATAACT 
GAATCTTGTC AGTGACGTTT GCCTCCAGCT GCCTGACAAA TAAGTCAGCA GCTTATACCC 
ACAGAAGCCA GTGCCAGTTG ACGCTGAAAG AATCAGGCAA AAAAGTGAGA ATGACCTTCA 
AACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005401.3
CDS	71..1216
Translation	MWRSLGLALALCLLPSGGTESQDQSSLCKQPPAWSIRDQDPMLNSNGSVTVVALLQASYLCILQASKLEDLRVKLKKEGYSNISYIVVNHQGISSRLKYTHLKNKVSEHIPVYQQEENQTDVWTLLNGSKDDFLIYDRCGRLVYHLGLPFSFLTFPYVEEAIKIAYCEKKCGNCSLTTLKDEDFCKRVSLATVDKTVETPSPHYHHEHHHNHGHQHLGSSELSENQQPGAPNAPTHPAPPGLHHHHKHKGQHRQGHPENRDMPASEDLQDLQKKLCRKRCINQLLCKLPTDSELAPRSCCHCRHLIFEKTGSAITQCKENLPSLCSQGLRAEENITESCQRLPPAAQISQQLIPTEASASRKNQAKKEPSN

Target ORF information:

RefSeq Version	NM_005410.4
Organism	Homo sapiens(human)
Definition	Homo sapiens selenoprotein P (SELENOP), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005410.4

ORF Insert Sequence:

ATGTGGAGAA GCCTGGGGCT TGCCCTGGCT CTCTGTCTCC TCCCATCGGG AGGAACAGAG 
AGCCAGGACC AAAGCTCCTT ATGTAAGCAA CCCCCAGCCT GGAGCATAAG AGATCAAGAT 
CCAATGCTAA ACTCCAATGG TTCAGTGACT GTGGTTGCTC TTCTTCAAGC CAGCTGATAC 
CTGTGCATAC TGCAGGCATC TAAATTAGAA GACCTGCGAG TAAAACTGAA GAAAGAAGGA 
TATTCTAATA TTTCTTATAT TGTTGTTAAT CATCAAGGAA TCTCTTCTCG ATTAAAATAC 
ACACATCTTA AGAATAAGGT TTCAGAGCAT ATTCCTGTTT ATCAACAAGA AGAAAACCAA 
ACAGATGTCT GGACTCTTTT AAATGGAAGC AAAGATGACT TCCTCATATA TGATAGATGT 
GGCCGTCTTG TATATCATCT TGGTTTGCCT TTTTCCTTCC TAACTTTCCC ATATGTAGAA 
GAAGCCATTA AGATTGCTTA CTGTGAAAAG AAATGTGGAA ACTGCTCTCT CACGACTCTC 
AAAGATGAAG ACTTTTGTAA ACGTGTATCT TTGGCTACTG TGGATAAAAC AGTTGAAACT 
CCATCGCCTC ATTACCATCA TGAGCATCAT CACAATCATG GACATCAGCA CCTTGGCAGC 
AGTGAGCTTT CAGAGAATCA GCAACCAGGA GCACCAAATG CTCCTACTCA TCCTGCTCCT 
CCAGGCCTTC ATCACCACCA TAAGCACAAG GGTCAGCATA GGCAGGGTCA CCCAGAGAAC 
CGAGATATGC CAGCAAGTGA AGATTTACAA GATTTACAAA AGAAGCTCTG TCGAAAGAGA 
TGTATAAATC AATTACTCTG TAAATTGCCC ACAGATTCAG AGTTGGCTCC TAGGAGCTGA 
TGCTGCCATT GTCGACATCT GATATTTGAA AAAACAGGGT CTGCAATCAC CTGACAGTGT 
AAAGAAAACC TCCCATCTTT ATGTAGCTGA CAGGGACTTC GGGCAGAGGA GAACATAACT 
GAATCTTGTC AGTGACGTTT GCCTCCAGCT GCCTGACAAA TAAGTCAGCA GCTTATACCC 
ACAGAAGCCA GTGCCAGTTG ACGCTGAAAG AATCAGGCAA AAAAGTGAGA ATGACCTTCA 
AACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SELENOP ( NM_005410.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_005401.3 Homo sapiens selenoprotein P, plasma, 1 (SEPP1), transcript variant 1, mRNA.

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CloneID	OHu13285
Clone ID Related Accession (Same CDS sequence)	NM_001085486.1 , NM_001085486.2 , NM_005410.4 , NM_005410.2 , NM_005410.3
Accession Version	NM_005410.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1146bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-07-09
Organism	Homo sapiens(Human)
Product	selenoprotein P isoform 1 precursor
Comment

ATGTGGAGAA GCCTGGGGCT TGCCCTGGCT CTCTGTCTCC TCCCATCGGG AGGAACAGAG 
AGCCAGGACC AAAGCTCCTT ATGTAAGCAA CCCCCAGCCT GGAGCATAAG AGATCAAGAT 
CCAATGCTAA ACTCCAATGG TTCAGTGACT GTGGTTGCTC TTCTTCAAGC CAGCTGATAC 
CTGTGCATAC TGCAGGCATC TAAATTAGAA GACCTGCGAG TAAAACTGAA GAAAGAAGGA 
TATTCTAATA TTTCTTATAT TGTTGTTAAT CATCAAGGAA TCTCTTCTCG ATTAAAATAC 
ACACATCTTA AGAATAAGGT TTCAGAGCAT ATTCCTGTTT ATCAACAAGA AGAAAACCAA 
ACAGATGTCT GGACTCTTTT AAATGGAAGC AAAGATGACT TCCTCATATA TGATAGATGT 
GGCCGTCTTG TATATCATCT TGGTTTGCCT TTTTCCTTCC TAACTTTCCC ATATGTAGAA 
GAAGCCATTA AGATTGCTTA CTGTGAAAAG AAATGTGGAA ACTGCTCTCT CACGACTCTC 
AAAGATGAAG ACTTTTGTAA ACGTGTATCT TTGGCTACTG TGGATAAAAC AGTTGAAACT 
CCATCGCCTC ATTACCATCA TGAGCATCAT CACAATCATG GACATCAGCA CCTTGGCAGC 
AGTGAGCTTT CAGAGAATCA GCAACCAGGA GCACCAAATG CTCCTACTCA TCCTGCTCCT 
CCAGGCCTTC ATCACCACCA TAAGCACAAG GGTCAGCATA GGCAGGGTCA CCCAGAGAAC 
CGAGATATGC CAGCAAGTGA AGATTTACAA GATTTACAAA AGAAGCTCTG TCGAAAGAGA 
TGTATAAATC AATTACTCTG TAAATTGCCC ACAGATTCAG AGTTGGCTCC TAGGAGCTGA 
TGCTGCCATT GTCGACATCT GATATTTGAA AAAACAGGGT CTGCAATCAC CTGACAGTGT 
AAAGAAAACC TCCCATCTTT ATGTAGCTGA CAGGGACTTC GGGCAGAGGA GAACATAACT 
GAATCTTGTC AGTGACGTTT GCCTCCAGCT GCCTGACAAA TAAGTCAGCA GCTTATACCC 
ACAGAAGCCA GTGCCAGTTG ACGCTGAAAG AATCAGGCAA AAAAGTGAGA ATGACCTTCA 
AACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005401.3
Translation	MWRSLGLALALCLLPSGGTESQDQSSLCKQPPAWSIRDQDPMLNSNGSVTVVALLQASYLCILQASKLEDLRVKLKKEGYSNISYIVVNHQGISSRLKYTHLKNKVSEHIPVYQQEENQTDVWTLLNGSKDDFLIYDRCGRLVYHLGLPFSFLTFPYVEEAIKIAYCEKKCGNCSLTTLKDEDFCKRVSLATVDKTVETPSPHYHHEHHHNHGHQHLGSSELSENQQPGAPNAPTHPAPPGLHHHHKHKGQHRQGHPENRDMPASEDLQDLQKKLCRKRCINQLLCKLPTDSELAPRSCCHCRHLIFEKTGSAITQCKENLPSLCSQGLRAEENITESCQRLPPAAQISQQLIPTEASASRKNQAKKEPSN

Target ORF information:

RefSeq Version	NM_005410.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens selenoprotein P, plasma, 1 (SEPP1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005410.2

ORF Insert Sequence:

ATGTGGAGAA GCCTGGGGCT TGCCCTGGCT CTCTGTCTCC TCCCATCGGG AGGAACAGAG 
AGCCAGGACC AAAGCTCCTT ATGTAAGCAA CCCCCAGCCT GGAGCATAAG AGATCAAGAT 
CCAATGCTAA ACTCCAATGG TTCAGTGACT GTGGTTGCTC TTCTTCAAGC CAGCTGATAC 
CTGTGCATAC TGCAGGCATC TAAATTAGAA GACCTGCGAG TAAAACTGAA GAAAGAAGGA 
TATTCTAATA TTTCTTATAT TGTTGTTAAT CATCAAGGAA TCTCTTCTCG ATTAAAATAC 
ACACATCTTA AGAATAAGGT TTCAGAGCAT ATTCCTGTTT ATCAACAAGA AGAAAACCAA 
ACAGATGTCT GGACTCTTTT AAATGGAAGC AAAGATGACT TCCTCATATA TGATAGATGT 
GGCCGTCTTG TATATCATCT TGGTTTGCCT TTTTCCTTCC TAACTTTCCC ATATGTAGAA 
GAAGCCATTA AGATTGCTTA CTGTGAAAAG AAATGTGGAA ACTGCTCTCT CACGACTCTC 
AAAGATGAAG ACTTTTGTAA ACGTGTATCT TTGGCTACTG TGGATAAAAC AGTTGAAACT 
CCATCGCCTC ATTACCATCA TGAGCATCAT CACAATCATG GACATCAGCA CCTTGGCAGC 
AGTGAGCTTT CAGAGAATCA GCAACCAGGA GCACCAAATG CTCCTACTCA TCCTGCTCCT 
CCAGGCCTTC ATCACCACCA TAAGCACAAG GGTCAGCATA GGCAGGGTCA CCCAGAGAAC 
CGAGATATGC CAGCAAGTGA AGATTTACAA GATTTACAAA AGAAGCTCTG TCGAAAGAGA 
TGTATAAATC AATTACTCTG TAAATTGCCC ACAGATTCAG AGTTGGCTCC TAGGAGCTGA 
TGCTGCCATT GTCGACATCT GATATTTGAA AAAACAGGGT CTGCAATCAC CTGACAGTGT 
AAAGAAAACC TCCCATCTTT ATGTAGCTGA CAGGGACTTC GGGCAGAGGA GAACATAACT 
GAATCTTGTC AGTGACGTTT GCCTCCAGCT GCCTGACAAA TAAGTCAGCA GCTTATACCC 
ACAGAAGCCA GTGCCAGTTG ACGCTGAAAG AATCAGGCAA AAAAGTGAGA ATGACCTTCA 
AACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SELENOP ( NM_005410.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005401.3 Homo sapiens selenoprotein P (SELENOP), transcript variant 1, mRNA.

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CloneID	OHu13285
Clone ID Related Accession (Same CDS sequence)	NM_001085486.1 , NM_001085486.2 , NM_005410.4 , NM_005410.2 , NM_005410.3
Accession Version	NM_005410.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1146bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-29
Organism	Homo sapiens(human)
Product	selenoprotein P isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA288385.1, BC040075.1 and HM005482.1. On Feb 9, 2017 this sequence version replaced NM_005410.2. Transcript Variant: This variant (1, also known as Sepp1a) represents the predominant transcript and encodes isoform 1. Variants 1 and 2 encode the same isoform. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AL833145.1, SRR1660805.187657.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: PMID: 8421687 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTGGAGAA GCCTGGGGCT TGCCCTGGCT CTCTGTCTCC TCCCATCGGG AGGAACAGAG 
AGCCAGGACC AAAGCTCCTT ATGTAAGCAA CCCCCAGCCT GGAGCATAAG AGATCAAGAT 
CCAATGCTAA ACTCCAATGG TTCAGTGACT GTGGTTGCTC TTCTTCAAGC CAGCTGATAC 
CTGTGCATAC TGCAGGCATC TAAATTAGAA GACCTGCGAG TAAAACTGAA GAAAGAAGGA 
TATTCTAATA TTTCTTATAT TGTTGTTAAT CATCAAGGAA TCTCTTCTCG ATTAAAATAC 
ACACATCTTA AGAATAAGGT TTCAGAGCAT ATTCCTGTTT ATCAACAAGA AGAAAACCAA 
ACAGATGTCT GGACTCTTTT AAATGGAAGC AAAGATGACT TCCTCATATA TGATAGATGT 
GGCCGTCTTG TATATCATCT TGGTTTGCCT TTTTCCTTCC TAACTTTCCC ATATGTAGAA 
GAAGCCATTA AGATTGCTTA CTGTGAAAAG AAATGTGGAA ACTGCTCTCT CACGACTCTC 
AAAGATGAAG ACTTTTGTAA ACGTGTATCT TTGGCTACTG TGGATAAAAC AGTTGAAACT 
CCATCGCCTC ATTACCATCA TGAGCATCAT CACAATCATG GACATCAGCA CCTTGGCAGC 
AGTGAGCTTT CAGAGAATCA GCAACCAGGA GCACCAAATG CTCCTACTCA TCCTGCTCCT 
CCAGGCCTTC ATCACCACCA TAAGCACAAG GGTCAGCATA GGCAGGGTCA CCCAGAGAAC 
CGAGATATGC CAGCAAGTGA AGATTTACAA GATTTACAAA AGAAGCTCTG TCGAAAGAGA 
TGTATAAATC AATTACTCTG TAAATTGCCC ACAGATTCAG AGTTGGCTCC TAGGAGCTGA 
TGCTGCCATT GTCGACATCT GATATTTGAA AAAACAGGGT CTGCAATCAC CTGACAGTGT 
AAAGAAAACC TCCCATCTTT ATGTAGCTGA CAGGGACTTC GGGCAGAGGA GAACATAACT 
GAATCTTGTC AGTGACGTTT GCCTCCAGCT GCCTGACAAA TAAGTCAGCA GCTTATACCC 
ACAGAAGCCA GTGCCAGTTG ACGCTGAAAG AATCAGGCAA AAAAGTGAGA ATGACCTTCA 
AACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005401.3
CDS	255..1400
Translation	MWRSLGLALALCLLPSGGTESQDQSSLCKQPPAWSIRDQDPMLNSNGSVTVVALLQASYLCILQASKLEDLRVKLKKEGYSNISYIVVNHQGISSRLKYTHLKNKVSEHIPVYQQEENQTDVWTLLNGSKDDFLIYDRCGRLVYHLGLPFSFLTFPYVEEAIKIAYCEKKCGNCSLTTLKDEDFCKRVSLATVDKTVETPSPHYHHEHHHNHGHQHLGSSELSENQQPGAPNAPTHPAPPGLHHHHKHKGQHRQGHPENRDMPASEDLQDLQKKLCRKRCINQLLCKLPTDSELAPRSCCHCRHLIFEKTGSAITQCKENLPSLCSQGLRAEENITESCQRLPPAAQISQQLIPTEASASRKNQAKKEPSN

Target ORF information:

RefSeq Version	NM_005410.3
Organism	Homo sapiens(human)
Definition	Homo sapiens selenoprotein P (SELENOP), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005410.3

ORF Insert Sequence:

ATGTGGAGAA GCCTGGGGCT TGCCCTGGCT CTCTGTCTCC TCCCATCGGG AGGAACAGAG 
AGCCAGGACC AAAGCTCCTT ATGTAAGCAA CCCCCAGCCT GGAGCATAAG AGATCAAGAT 
CCAATGCTAA ACTCCAATGG TTCAGTGACT GTGGTTGCTC TTCTTCAAGC CAGCTGATAC 
CTGTGCATAC TGCAGGCATC TAAATTAGAA GACCTGCGAG TAAAACTGAA GAAAGAAGGA 
TATTCTAATA TTTCTTATAT TGTTGTTAAT CATCAAGGAA TCTCTTCTCG ATTAAAATAC 
ACACATCTTA AGAATAAGGT TTCAGAGCAT ATTCCTGTTT ATCAACAAGA AGAAAACCAA 
ACAGATGTCT GGACTCTTTT AAATGGAAGC AAAGATGACT TCCTCATATA TGATAGATGT 
GGCCGTCTTG TATATCATCT TGGTTTGCCT TTTTCCTTCC TAACTTTCCC ATATGTAGAA 
GAAGCCATTA AGATTGCTTA CTGTGAAAAG AAATGTGGAA ACTGCTCTCT CACGACTCTC 
AAAGATGAAG ACTTTTGTAA ACGTGTATCT TTGGCTACTG TGGATAAAAC AGTTGAAACT 
CCATCGCCTC ATTACCATCA TGAGCATCAT CACAATCATG GACATCAGCA CCTTGGCAGC 
AGTGAGCTTT CAGAGAATCA GCAACCAGGA GCACCAAATG CTCCTACTCA TCCTGCTCCT 
CCAGGCCTTC ATCACCACCA TAAGCACAAG GGTCAGCATA GGCAGGGTCA CCCAGAGAAC 
CGAGATATGC CAGCAAGTGA AGATTTACAA GATTTACAAA AGAAGCTCTG TCGAAAGAGA 
TGTATAAATC AATTACTCTG TAAATTGCCC ACAGATTCAG AGTTGGCTCC TAGGAGCTGA 
TGCTGCCATT GTCGACATCT GATATTTGAA AAAACAGGGT CTGCAATCAC CTGACAGTGT 
AAAGAAAACC TCCCATCTTT ATGTAGCTGA CAGGGACTTC GGGCAGAGGA GAACATAACT 
GAATCTTGTC AGTGACGTTT GCCTCCAGCT GCCTGACAAA TAAGTCAGCA GCTTATACCC 
ACAGAAGCCA GTGCCAGTTG ACGCTGAAAG AATCAGGCAA AAAAGTGAGA ATGACCTTCA 
AACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SELENOP ( NM_001093726.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001087195.1 Homo sapiens selenoprotein P (SELENOP), transcript variant 3, mRNA.

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CloneID	OHu13421
Clone ID Related Accession (Same CDS sequence)	NM_001093726.2
Accession Version	NM_001093726.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1236bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-15
Organism	Homo sapiens(human)
Product	selenoprotein P isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA288385.1, AL599162.1, BC040075.1 and HM005482.1. On Feb 9, 2017 this sequence version replaced NM_001093726.1. Transcript Variant: This variant (3, also known as Sepp1b) contains an additional 5' coding exon compared to variant 1. It initiates translation from an in-frame, upstream start codon, which results in an isoform (2) with a longer and distinct N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.170341.1, SRR1660807.133228.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2161836 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: PMID: 8421687 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTGCTCTG GGCTGGACGC GGTGGCTCAC GCTTGTAATC CCAGCACTTT GGGAGGCCAA 
GGCAGGCGGA TCACGAGGAC AACCCCAGCA ATGTGGAGAA GCCTGGGGCT TGCCCTGGCT 
CTCTGTCTCC TCCCATCGGG AGGAACAGAG AGCCAGGACC AAAGCTCCTT ATGTAAGCAA 
CCCCCAGCCT GGAGCATAAG AGATCAAGAT CCAATGCTAA ACTCCAATGG TTCAGTGACT 
GTGGTTGCTC TTCTTCAAGC CAGCTGATAC CTGTGCATAC TGCAGGCATC TAAATTAGAA 
GACCTGCGAG TAAAACTGAA GAAAGAAGGA TATTCTAATA TTTCTTATAT TGTTGTTAAT 
CATCAAGGAA TCTCTTCTCG ATTAAAATAC ACACATCTTA AGAATAAGGT TTCAGAGCAT 
ATTCCTGTTT ATCAACAAGA AGAAAACCAA ACAGATGTCT GGACTCTTTT AAATGGAAGC 
AAAGATGACT TCCTCATATA TGATAGATGT GGCCGTCTTG TATATCATCT TGGTTTGCCT 
TTTTCCTTCC TAACTTTCCC ATATGTAGAA GAAGCCATTA AGATTGCTTA CTGTGAAAAG 
AAATGTGGAA ACTGCTCTCT CACGACTCTC AAAGATGAAG ACTTTTGTAA ACGTGTATCT 
TTGGCTACTG TGGATAAAAC AGTTGAAACT CCATCGCCTC ATTACCATCA TGAGCATCAT 
CACAATCATG GACATCAGCA CCTTGGCAGC AGTGAGCTTT CAGAGAATCA GCAACCAGGA 
GCACCAAATG CTCCTACTCA TCCTGCTCCT CCAGGCCTTC ATCACCACCA TAAGCACAAG 
GGTCAGCATA GGCAGGGTCA CCCAGAGAAC CGAGATATGC CAGCAAGTGA AGATTTACAA 
GATTTACAAA AGAAGCTCTG TCGAAAGAGA TGTATAAATC AATTACTCTG TAAATTGCCC 
ACAGATTCAG AGTTGGCTCC TAGGAGCTGA TGCTGCCATT GTCGACATCT GATATTTGAA 
AAAACAGGGT CTGCAATCAC CTGACAGTGT AAAGAAAACC TCCCATCTTT ATGTAGCTGA 
CAGGGACTTC GGGCAGAGGA GAACATAACT GAATCTTGTC AGTGACGTTT GCCTCCAGCT 
GCCTGACAAA TAAGTCAGCA GCTTATACCC ACAGAAGCCA GTGCCAGTTG ACGCTGAAAG 
AATCAGGCAA AAAAGTGAGA ATGACCTTCA AACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001087195.1
CDS	253..1488
Translation	MCSGLDAVAHACNPSTLGGQGRRITRTTPAMWRSLGLALALCLLPSGGTESQDQSSLCKQPPAWSIRDQDPMLNSNGSVTVVALLQASYLCILQASKLEDLRVKLKKEGYSNISYIVVNHQGISSRLKYTHLKNKVSEHIPVYQQEENQTDVWTLLNGSKDDFLIYDRCGRLVYHLGLPFSFLTFPYVEEAIKIAYCEKKCGNCSLTTLKDEDFCKRVSLATVDKTVETPSPHYHHEHHHNHGHQHLGSSELSENQQPGAPNAPTHPAPPGLHHHHKHKGQHRQGHPENRDMPASEDLQDLQKKLCRKRCINQLLCKLPTDSELAPRSCCHCRHLIFEKTGSAITQCKENLPSLCSQGLRAEENITESCQRLPPAAQISQQLIPTEASASRKNQAKKEPSN

Target ORF information:

RefSeq Version	NM_001093726.2
Organism	Homo sapiens(human)
Definition	Homo sapiens selenoprotein P (SELENOP), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001093726.2

ORF Insert Sequence:

ATGTGCTCTG GGCTGGACGC GGTGGCTCAC GCTTGTAATC CCAGCACTTT GGGAGGCCAA 
GGCAGGCGGA TCACGAGGAC AACCCCAGCA ATGTGGAGAA GCCTGGGGCT TGCCCTGGCT 
CTCTGTCTCC TCCCATCGGG AGGAACAGAG AGCCAGGACC AAAGCTCCTT ATGTAAGCAA 
CCCCCAGCCT GGAGCATAAG AGATCAAGAT CCAATGCTAA ACTCCAATGG TTCAGTGACT 
GTGGTTGCTC TTCTTCAAGC CAGCTGATAC CTGTGCATAC TGCAGGCATC TAAATTAGAA 
GACCTGCGAG TAAAACTGAA GAAAGAAGGA TATTCTAATA TTTCTTATAT TGTTGTTAAT 
CATCAAGGAA TCTCTTCTCG ATTAAAATAC ACACATCTTA AGAATAAGGT TTCAGAGCAT 
ATTCCTGTTT ATCAACAAGA AGAAAACCAA ACAGATGTCT GGACTCTTTT AAATGGAAGC 
AAAGATGACT TCCTCATATA TGATAGATGT GGCCGTCTTG TATATCATCT TGGTTTGCCT 
TTTTCCTTCC TAACTTTCCC ATATGTAGAA GAAGCCATTA AGATTGCTTA CTGTGAAAAG 
AAATGTGGAA ACTGCTCTCT CACGACTCTC AAAGATGAAG ACTTTTGTAA ACGTGTATCT 
TTGGCTACTG TGGATAAAAC AGTTGAAACT CCATCGCCTC ATTACCATCA TGAGCATCAT 
CACAATCATG GACATCAGCA CCTTGGCAGC AGTGAGCTTT CAGAGAATCA GCAACCAGGA 
GCACCAAATG CTCCTACTCA TCCTGCTCCT CCAGGCCTTC ATCACCACCA TAAGCACAAG 
GGTCAGCATA GGCAGGGTCA CCCAGAGAAC CGAGATATGC CAGCAAGTGA AGATTTACAA 
GATTTACAAA AGAAGCTCTG TCGAAAGAGA TGTATAAATC AATTACTCTG TAAATTGCCC 
ACAGATTCAG AGTTGGCTCC TAGGAGCTGA TGCTGCCATT GTCGACATCT GATATTTGAA 
AAAACAGGGT CTGCAATCAC CTGACAGTGT AAAGAAAACC TCCCATCTTT ATGTAGCTGA 
CAGGGACTTC GGGCAGAGGA GAACATAACT GAATCTTGTC AGTGACGTTT GCCTCCAGCT 
GCCTGACAAA TAAGTCAGCA GCTTATACCC ACAGAAGCCA GTGCCAGTTG ACGCTGAAAG 
AATCAGGCAA AAAAGTGAGA ATGACCTTCA AACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Multiple RNA structures affect translation initiation and UGA redefinition efficiency during synthesis of selenoprotein P.
Nucleic acids research45(22)13004-13015(2017 Dec)
Mariotti M,Shetty S,Baird L,Wu S,Loughran G,Copeland PR,Atkins JF,Howard MT

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SELENOP cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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