LIN7B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	LIN7B
Entrez Gene ID	64130
Full Name	lin-7 homolog B, crumbs cell polarity complex component
Synonyms	LIN-7B,MALS-2,MALS2,VELI2
General protein information	Preferred Names lin-7 homolog B, crumbs cell polarity complex component Names protein lin-7 homolog B hLin7B hVeli2 mammalian lin-seven protein 2 veli-2 vertebrate lin-7 homolog 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.33
Disorder MIM:	612331

mRNA and Protein(s)

mRNA	Protein	Name
XM_017027131.2	XP_016882620.1	protein lin-7 homolog B isoform X2
XM_017027131.1	XP_016882620.1	protein lin-7 homolog B isoform X2
NM_022165.3	NP_071448.1	protein lin-7 homolog B isoform 1
NM_001308419.2	NP_001295348.1	protein lin-7 homolog B isoform 2
NM_022165.2	NP_071448.1	protein lin-7 homolog B isoform 1
XM_006723323.3	XP_006723386.1	protein lin-7 homolog B isoform X1
NM_001308419.1	NP_001295348.1	protein lin-7 homolog B isoform 2

Pathways from BioSystems

Homologies

	LIN7B	XP_001114658.1
Bos taurus (cattle)	LIN7B	NP_001040042.1
Drosophila melanogaster (fruit fly)	veli	NP_651330.1
Homo sapiens (human)	LIN7B	NP_071448.1
Mus musculus (house mouse)	Lin7b	NP_035828.1
Danio rerio (zebrafish)	lin7b	NP_001018569.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005858	XP_315884.3
Xenopus tropicalis (tropical clawed frog)	lin7b	XP_002934676.1
Canis lupus familiaris (dog)	LIN7B	XP_851922.2
Rattus norvegicus (Norway rat)	Lin7b	NP_068526.1
Caenorhabditis elegans (roundworm)	lin-7	NP_001122664.2

Gene Ontology
Bibliography

Related articles in PubMed

Role of an adaptor protein Lin-7B in brain development: possible involvement in autism spectrum disorders.
Mizuno M, Matsumoto A, Hamada N, Ito H, Miyauchi A, Jimbo EF, Momoi MY, Tabata H, Yamagata T, Nagata K
Journal of neurochemistry132(1)61-9(2015 Jan)

Decreased Lin7b expression in layer 5 pyramidal neurons may contribute to impaired corticostriatal connectivity in huntington disease.
Zucker B, Kama JA, Kuhn A, Thu D, Orlando LR, Dunah AW, Gokce O, Taylor DM, Lambeck J, Friedrich B, Lindenberg KS, Faull RL, Weiller C, Young AB, Luthi-Carter R
Journal of neuropathology and experimental neurology69(9)880-95(2010 Sep)

Association study of brain-derived neurotrophic factor (BDNF) and LIN-7 homolog (LIN-7) genes with adult attention-deficit/hyperactivity disorder.
Lanktree M, Squassina A, Krinsky M, Strauss J, Jain U, Macciardi F, Kennedy JL, Muglia P
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics147B(6)945-51(2008 Sep)

The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions.
Bohl J, Brimer N, Lyons C, Vande Pol SB
The Journal of biological chemistry282(13)9392-400(2007 Mar)

Identification of a cell polarity-related protein, Lin-7B, as a binding partner for a Rho effector, Rhotekin, and their possible interaction in neurons.
Sudo K, Ito H, Iwamoto I, Morishita R, Asano T, Nagata K
Neuroscience research56(4)347-55(2006 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

functional deficiency in Lin-7B could be implicated in clinical phenotypes in some autism spectrum disorders patients through bringing about abnormal cortical architecture
Title: Role of an adaptor protein Lin-7B in brain development: possible involvement in autism spectrum disorders.

Data suggest that decreased cortical LIN7b expression may contribute to abnormal corticostriatal connectivity in Huntington disease.
Title: Decreased Lin7b expression in layer 5 pyramidal neurons may contribute to impaired corticostriatal connectivity in huntington disease.

Allelic and haplotype association was found between both BDNF and adult ADHD, and LIN-7 and adult ADHD.
Title: Association study of brain-derived neurotrophic factor (BDNF) and LIN-7 homolog (LIN-7) genes with adult attention-deficit/hyperactivity disorder.

Lin-7B is a binding partner for Rhotekin in the human brain cDNA library
Title: Identification of a cell polarity-related protein, Lin-7B, as a binding partner for a Rho effector, Rhotekin, and their possible interaction in neurons.

PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current
Title: PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current.

The following LIN7B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LIN7B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03838	NM_022165.3 Latest version!	Homo sapiens lin-7 homolog B, crumbs cell polarity complex component (LIN7B), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu52427	NM_001308419.2 Latest version!	Homo sapiens lin-7 homolog B, crumbs cell polarity complex component (LIN7B), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu52426	XM_006723323.3 Latest version!	Homo sapiens lin-7 homolog B, crumbs cell polarity complex component (LIN7B), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu88658	XM_017027131.2 Latest version!	Homo sapiens lin-7 homolog B, crumbs cell polarity complex component (LIN7B), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu88658	XM_017027131.1	Homo sapiens lin-7 homolog B, crumbs cell polarity complex component (LIN7B), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu03838	NM_022165.2	Homo sapiens lin-7 homolog B, crumbs cell polarity complex component (LIN7B), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu52427	NM_001308419.1	Homo sapiens lin-7 homolog B, crumbs cell polarity complex component (LIN7B), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LIN7B ( NM_022165.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_071448.1 Homo sapiens lin-7 homolog B, crumbs cell polarity complex component (LIN7B), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu03838
Clone ID Related Accession (Same CDS sequence)	NM_022165.3 , NM_022165.2
Accession Version	NM_022165.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 624bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Homo sapiens(human)
Product	protein lin-7 homolog B isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY358744.1. On Nov 23, 2018 this sequence version replaced NM_022165.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY358744.1, SRR5189661.15876.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000221459.7/ ENSP00000221459.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTGCGC TGGTGGAGCC GCTGGGGCTG GAGCGGGACG TGTCCCGGGC GGTTGAGCTC 
CTCGAGCGGC TCCAGCGCAG CGGGGAGCTG CCGCCGCAGA AGCTGCAGGC CCTCCAGCGA 
GTTCTGCAGA GCCGCTTCTG CTCCGCTATC CGAGAGGTGT ATGAGCAGCT TTATGACACG 
CTGGACATCA CCGGCAGCGC CGAGATCCGA GCCCATGCCA CAGCCAAGGC CACAGTGGCT 
GCCTTCACAG CCAGCGAGGG CCACGCACAT CCCAGGGTAG TGGAGCTACC CAAGACGGAT 
GAGGGCCTAG GCTTCAACAT CATGGGTGGC AAAGAGCAAA ACTCGCCCAT CTACATCTCC 
CGGGTCATCC CAGGGGGTGT GGCTGACCGC CATGGAGGCC TCAAGCGTGG GGATCAACTG 
TTGTCGGTGA ACGGTGTGAG CGTTGAGGGT GAGCAGCATG AGAAGGCGGT GGAGCTGCTG 
AAGGCGGCCC AGGGCTCGGT GAAGCTGGTT GTCCGTTACA CACCGCGAGT GCTGGAGGAG 
ATGGAGGCCC GGTTCGAGAA GATGCGCTCT GCCCGCCGGC GCCAACAGCA TCAGAGCTAC 
TCGTCCTTGG AGTCTCGAGG TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071448.1
CDS	36..659
Translation	MAALVEPLGLERDVSRAVELLERLQRSGELPPQKLQALQRVLQSRFCSAIREVYEQLYDTLDITGSAEIRAHATAKATVAAFTASEGHAHPRVVELPKTDEGLGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAVELLKAAQGSVKLVVRYTPRVLEEMEARFEKMRSARRRQQHQSYSSLESRG

Target ORF information:

RefSeq Version	NM_022165.3
Organism	Homo sapiens(human)
Definition	Homo sapiens lin-7 homolog B, crumbs cell polarity complex component (LIN7B), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022165.3

ORF Insert Sequence:

ATGGCTGCGC TGGTGGAGCC GCTGGGGCTG GAGCGGGACG TGTCCCGGGC GGTTGAGCTC 
CTCGAGCGGC TCCAGCGCAG CGGGGAGCTG CCGCCGCAGA AGCTGCAGGC CCTCCAGCGA 
GTTCTGCAGA GCCGCTTCTG CTCCGCTATC CGAGAGGTGT ATGAGCAGCT TTATGACACG 
CTGGACATCA CCGGCAGCGC CGAGATCCGA GCCCATGCCA CAGCCAAGGC CACAGTGGCT 
GCCTTCACAG CCAGCGAGGG CCACGCACAT CCCAGGGTAG TGGAGCTACC CAAGACGGAT 
GAGGGCCTAG GCTTCAACAT CATGGGTGGC AAAGAGCAAA ACTCGCCCAT CTACATCTCC 
CGGGTCATCC CAGGGGGTGT GGCTGACCGC CATGGAGGCC TCAAGCGTGG GGATCAACTG 
TTGTCGGTGA ACGGTGTGAG CGTTGAGGGT GAGCAGCATG AGAAGGCGGT GGAGCTGCTG 
AAGGCGGCCC AGGGCTCGGT GAAGCTGGTT GTCCGTTACA CACCGCGAGT GCTGGAGGAG 
ATGGAGGCCC GGTTCGAGAA GATGCGCTCT GCCCGCCGGC GCCAACAGCA TCAGAGCTAC 
TCGTCCTTGG AGTCTCGAGG TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LIN7B ( NM_022165.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_071448.1 Homo sapiens lin-7 homolog B, crumbs cell polarity complex component (LIN7B), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu03838
Clone ID Related Accession (Same CDS sequence)	NM_022165.3 , NM_022165.2
Accession Version	NM_022165.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 624bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-14
Organism	Homo sapiens(human)
Product	protein lin-7 homolog B isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY358744.1. On Dec 16, 2004 this sequence version replaced NM_022165.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY358744.1, SRR1803617.370842.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGCGC TGGTGGAGCC GCTGGGGCTG GAGCGGGACG TGTCCCGGGC GGTTGAGCTC 
CTCGAGCGGC TCCAGCGCAG CGGGGAGCTG CCGCCGCAGA AGCTGCAGGC CCTCCAGCGA 
GTTCTGCAGA GCCGCTTCTG CTCCGCTATC CGAGAGGTGT ATGAGCAGCT TTATGACACG 
CTGGACATCA CCGGCAGCGC CGAGATCCGA GCCCATGCCA CAGCCAAGGC CACAGTGGCT 
GCCTTCACAG CCAGCGAGGG CCACGCACAT CCCAGGGTAG TGGAGCTACC CAAGACGGAT 
GAGGGCCTAG GCTTCAACAT CATGGGTGGC AAAGAGCAAA ACTCGCCCAT CTACATCTCC 
CGGGTCATCC CAGGGGGTGT GGCTGACCGC CATGGAGGCC TCAAGCGTGG GGATCAACTG 
TTGTCGGTGA ACGGTGTGAG CGTTGAGGGT GAGCAGCATG AGAAGGCGGT GGAGCTGCTG 
AAGGCGGCCC AGGGCTCGGT GAAGCTGGTT GTCCGTTACA CACCGCGAGT GCTGGAGGAG 
ATGGAGGCCC GGTTCGAGAA GATGCGCTCT GCCCGCCGGC GCCAACAGCA TCAGAGCTAC 
TCGTCCTTGG AGTCTCGAGG TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071448.1
CDS	45..668
Translation	MAALVEPLGLERDVSRAVELLERLQRSGELPPQKLQALQRVLQSRFCSAIREVYEQLYDTLDITGSAEIRAHATAKATVAAFTASEGHAHPRVVELPKTDEGLGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAVELLKAAQGSVKLVVRYTPRVLEEMEARFEKMRSARRRQQHQSYSSLESRG

Target ORF information:

RefSeq Version	NM_022165.2
Organism	Homo sapiens(human)
Definition	Homo sapiens lin-7 homolog B, crumbs cell polarity complex component (LIN7B), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022165.2

ORF Insert Sequence:

ATGGCTGCGC TGGTGGAGCC GCTGGGGCTG GAGCGGGACG TGTCCCGGGC GGTTGAGCTC 
CTCGAGCGGC TCCAGCGCAG CGGGGAGCTG CCGCCGCAGA AGCTGCAGGC CCTCCAGCGA 
GTTCTGCAGA GCCGCTTCTG CTCCGCTATC CGAGAGGTGT ATGAGCAGCT TTATGACACG 
CTGGACATCA CCGGCAGCGC CGAGATCCGA GCCCATGCCA CAGCCAAGGC CACAGTGGCT 
GCCTTCACAG CCAGCGAGGG CCACGCACAT CCCAGGGTAG TGGAGCTACC CAAGACGGAT 
GAGGGCCTAG GCTTCAACAT CATGGGTGGC AAAGAGCAAA ACTCGCCCAT CTACATCTCC 
CGGGTCATCC CAGGGGGTGT GGCTGACCGC CATGGAGGCC TCAAGCGTGG GGATCAACTG 
TTGTCGGTGA ACGGTGTGAG CGTTGAGGGT GAGCAGCATG AGAAGGCGGT GGAGCTGCTG 
AAGGCGGCCC AGGGCTCGGT GAAGCTGGTT GTCCGTTACA CACCGCGAGT GCTGGAGGAG 
ATGGAGGCCC GGTTCGAGAA GATGCGCTCT GCCCGCCGGC GCCAACAGCA TCAGAGCTAC 
TCGTCCTTGG AGTCTCGAGG TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LIN7B ( NM_001308419.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001295348.1 Homo sapiens lin-7 homolog B, crumbs cell polarity complex component (LIN7B), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu52427
Clone ID Related Accession (Same CDS sequence)	NM_001308419.2 , NM_001308419.1
Accession Version	NM_001308419.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 414bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	protein lin-7 homolog B isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY358744.1, BM069859.1 and AF311862.1. On Jun 1, 2019 this sequence version replaced NM_001308419.1. Transcript Variant: This variant (2) lacks an in-frame exon compared to variant 1. It encodes isoform 2, which is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BM069859.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142680 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGCGC TGGTGGAGCC GCTGGGGCTG GAGCGGGACG TGTCCCGGGC GGTTGAGCTC 
CTCGAGCGGC TCCAGCGCAG CGGGGAGCTG CCGCCGCAGA AGCTGCAGGC CCTCCAGCGA 
GTTCTGCAGA GCCGCTTCTG CTCCGCTATC CGAGAGGTGT ATGAGCAGCT TTATGACACG 
CTGGACATCA CCGGCAGCGC CGAGATCCGA GCCCATGCCA CAGCCAAGAG CGTTGAGGGT 
GAGCAGCATG AGAAGGCGGT GGAGCTGCTG AAGGCGGCCC AGGGCTCGGT GAAGCTGGTT 
GTCCGTTACA CACCGCGAGT GCTGGAGGAG ATGGAGGCCC GGTTCGAGAA GATGCGCTCT 
GCCCGCCGGC GCCAACAGCA TCAGAGCTAC TCGTCCTTGG AGTCTCGAGG TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001295348.1
CDS	36..449
Translation	MAALVEPLGLERDVSRAVELLERLQRSGELPPQKLQALQRVLQSRFCSAIREVYEQLYDTLDITGSAEIRAHATAKSVEGEQHEKAVELLKAAQGSVKLVVRYTPRVLEEMEARFEKMRSARRRQQHQSYSSLESRG

Target ORF information:

RefSeq Version	NM_001308419.2
Organism	Homo sapiens(human)
Definition	Homo sapiens lin-7 homolog B, crumbs cell polarity complex component (LIN7B), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001308419.2

ORF Insert Sequence:

ATGGCTGCGC TGGTGGAGCC GCTGGGGCTG GAGCGGGACG TGTCCCGGGC GGTTGAGCTC 
CTCGAGCGGC TCCAGCGCAG CGGGGAGCTG CCGCCGCAGA AGCTGCAGGC CCTCCAGCGA 
GTTCTGCAGA GCCGCTTCTG CTCCGCTATC CGAGAGGTGT ATGAGCAGCT TTATGACACG 
CTGGACATCA CCGGCAGCGC CGAGATCCGA GCCCATGCCA CAGCCAAGAG CGTTGAGGGT 
GAGCAGCATG AGAAGGCGGT GGAGCTGCTG AAGGCGGCCC AGGGCTCGGT GAAGCTGGTT 
GTCCGTTACA CACCGCGAGT GCTGGAGGAG ATGGAGGCCC GGTTCGAGAA GATGCGCTCT 
GCCCGCCGGC GCCAACAGCA TCAGAGCTAC TCGTCCTTGG AGTCTCGAGG TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LIN7B ( NM_001308419.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001295348.1 Homo sapiens lin-7 homolog B, crumbs cell polarity complex component (LIN7B), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu52427
Clone ID Related Accession (Same CDS sequence)	NM_001308419.2 , NM_001308419.1
Accession Version	NM_001308419.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 414bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-30
Organism	Homo sapiens(human)
Product	protein lin-7 homolog B isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY358744.1, BM069859.1 and AF311862.1. On May 5, 2015 this sequence version replaced XM_005259149.2. Transcript Variant: This variant (2) lacks an in-frame exon compared to variant 1. It encodes isoform 2, which is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BM069859.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142680 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGCGC TGGTGGAGCC GCTGGGGCTG GAGCGGGACG TGTCCCGGGC GGTTGAGCTC 
CTCGAGCGGC TCCAGCGCAG CGGGGAGCTG CCGCCGCAGA AGCTGCAGGC CCTCCAGCGA 
GTTCTGCAGA GCCGCTTCTG CTCCGCTATC CGAGAGGTGT ATGAGCAGCT TTATGACACG 
CTGGACATCA CCGGCAGCGC CGAGATCCGA GCCCATGCCA CAGCCAAGAG CGTTGAGGGT 
GAGCAGCATG AGAAGGCGGT GGAGCTGCTG AAGGCGGCCC AGGGCTCGGT GAAGCTGGTT 
GTCCGTTACA CACCGCGAGT GCTGGAGGAG ATGGAGGCCC GGTTCGAGAA GATGCGCTCT 
GCCCGCCGGC GCCAACAGCA TCAGAGCTAC TCGTCCTTGG AGTCTCGAGG TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001295348.1
CDS	45..458
Translation	MAALVEPLGLERDVSRAVELLERLQRSGELPPQKLQALQRVLQSRFCSAIREVYEQLYDTLDITGSAEIRAHATAKSVEGEQHEKAVELLKAAQGSVKLVVRYTPRVLEEMEARFEKMRSARRRQQHQSYSSLESRG

Target ORF information:

RefSeq Version	NM_001308419.1
Organism	Homo sapiens(human)
Definition	Homo sapiens lin-7 homolog B, crumbs cell polarity complex component (LIN7B), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001308419.1

ORF Insert Sequence:

ATGGCTGCGC TGGTGGAGCC GCTGGGGCTG GAGCGGGACG TGTCCCGGGC GGTTGAGCTC 
CTCGAGCGGC TCCAGCGCAG CGGGGAGCTG CCGCCGCAGA AGCTGCAGGC CCTCCAGCGA 
GTTCTGCAGA GCCGCTTCTG CTCCGCTATC CGAGAGGTGT ATGAGCAGCT TTATGACACG 
CTGGACATCA CCGGCAGCGC CGAGATCCGA GCCCATGCCA CAGCCAAGAG CGTTGAGGGT 
GAGCAGCATG AGAAGGCGGT GGAGCTGCTG AAGGCGGCCC AGGGCTCGGT GAAGCTGGTT 
GTCCGTTACA CACCGCGAGT GCTGGAGGAG ATGGAGGCCC GGTTCGAGAA GATGCGCTCT 
GCCCGCCGGC GCCAACAGCA TCAGAGCTAC TCGTCCTTGG AGTCTCGAGG TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LIN7B ( XM_006723323.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_006723386.1 Homo sapiens lin-7 homolog B, crumbs cell polarity complex component (LIN7B), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu52426
Clone ID Related Accession (Same CDS sequence)	XM_006723323.3
Accession Version	XM_006723323.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 552bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	protein lin-7 homolog B isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_006723323.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTGCGC TGGTGGAGCC GCTGGGGCTG GAGCGGGACG TGTCCCGGGC GGTTGAGCTC 
CTCGAGCGGC TCCAGCGCAG CGGGGAGCTG CCGCCGCAGA AGCTGCAGGC CCTCCAGCGA 
GTTCTGCAGA GCCGCTTCTG CTCCGCTATC CGAGAGGCCA CAGTGGCTGC CTTCACAGCC 
AGCGAGGGCC ACGCACATCC CAGGGTAGTG GAGCTACCCA AGACGGATGA GGGCCTAGGC 
TTCAACATCA TGGGTGGCAA AGAGCAAAAC TCGCCCATCT ACATCTCCCG GGTCATCCCA 
GGGGGTGTGG CTGACCGCCA TGGAGGCCTC AAGCGTGGGG ATCAACTGTT GTCGGTGAAC 
GGTGTGAGCG TTGAGGGTGA GCAGCATGAG AAGGCGGTGG AGCTGCTGAA GGCGGCCCAG 
GGCTCGGTGA AGCTGGTTGT CCGTTACACA CCGCGAGTGC TGGAGGAGAT GGAGGCCCGG 
TTCGAGAAGA TGCGCTCTGC CCGCCGGCGC CAACAGCATC AGAGCTACTC GTCCTTGGAG 
TCTCGAGGTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006723386.1
CDS	65..616
Translation	MAALVEPLGLERDVSRAVELLERLQRSGELPPQKLQALQRVLQSRFCSAIREATVAAFTASEGHAHPRVVELPKTDEGLGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAVELLKAAQGSVKLVVRYTPRVLEEMEARFEKMRSARRRQQHQSYSSLESRG

Target ORF information:

RefSeq Version	XM_006723323.3
Organism	Homo sapiens(human)
Definition	Homo sapiens lin-7 homolog B, crumbs cell polarity complex component (LIN7B), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006723323.3

ORF Insert Sequence:

ATGGCTGCGC TGGTGGAGCC GCTGGGGCTG GAGCGGGACG TGTCCCGGGC GGTTGAGCTC 
CTCGAGCGGC TCCAGCGCAG CGGGGAGCTG CCGCCGCAGA AGCTGCAGGC CCTCCAGCGA 
GTTCTGCAGA GCCGCTTCTG CTCCGCTATC CGAGAGGCCA CAGTGGCTGC CTTCACAGCC 
AGCGAGGGCC ACGCACATCC CAGGGTAGTG GAGCTACCCA AGACGGATGA GGGCCTAGGC 
TTCAACATCA TGGGTGGCAA AGAGCAAAAC TCGCCCATCT ACATCTCCCG GGTCATCCCA 
GGGGGTGTGG CTGACCGCCA TGGAGGCCTC AAGCGTGGGG ATCAACTGTT GTCGGTGAAC 
GGTGTGAGCG TTGAGGGTGA GCAGCATGAG AAGGCGGTGG AGCTGCTGAA GGCGGCCCAG 
GGCTCGGTGA AGCTGGTTGT CCGTTACACA CCGCGAGTGC TGGAGGAGAT GGAGGCCCGG 
TTCGAGAAGA TGCGCTCTGC CCGCCGGCGC CAACAGCATC AGAGCTACTC GTCCTTGGAG 
TCTCGAGGTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LIN7B ( XM_017027131.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_016882620.1 Homo sapiens lin-7 homolog B, crumbs cell polarity complex component (LIN7B), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu88658
Clone ID Related Accession (Same CDS sequence)	XM_017027131.2 , XM_017027131.1
Accession Version	XM_017027131.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 318bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	protein lin-7 homolog B isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017027131.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTGCGC TGGTGGAGCC GCTGGGGCTG GAGCGGGACG TGTCCCGGGC GGTTGAGCTC 
CTCGAGCGGC TCCAGCGCAG CGGGGAGCTG CCGCCGCAGA AGCTGCAGGC CCTCCAGCGA 
GTTCTGCAGA GCCGCTTCTG CTCCGCTATC CGAGAGGGCT GGAGGAGCTG GCGACTCCCT 
GATGCCGCTG CCTCCTCACC CAGGTGTATG AGCAGCTTTA TGACACGCTG GACATCACCG 
GCAGCGCCGA GATCCGAGCC CATGCCACAG CCAAGAGCGT TGAGGGTGAG CAGCATGAGA 
AGGCGGTGGA GCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016882620.1
CDS	67..384
Translation	MAALVEPLGLERDVSRAVELLERLQRSGELPPQKLQALQRVLQSRFCSAIREGWRSWRLPDAAASSPRCMSSFMTRWTSPAAPRSEPMPQPRALRVSSMRRRWSC

Target ORF information:

RefSeq Version	XM_017027131.2
Organism	Homo sapiens(human)
Definition	Homo sapiens lin-7 homolog B, crumbs cell polarity complex component (LIN7B), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017027131.2

ORF Insert Sequence:

ATGGCTGCGC TGGTGGAGCC GCTGGGGCTG GAGCGGGACG TGTCCCGGGC GGTTGAGCTC 
CTCGAGCGGC TCCAGCGCAG CGGGGAGCTG CCGCCGCAGA AGCTGCAGGC CCTCCAGCGA 
GTTCTGCAGA GCCGCTTCTG CTCCGCTATC CGAGAGGGCT GGAGGAGCTG GCGACTCCCT 
GATGCCGCTG CCTCCTCACC CAGGTGTATG AGCAGCTTTA TGACACGCTG GACATCACCG 
GCAGCGCCGA GATCCGAGCC CATGCCACAG CCAAGAGCGT TGAGGGTGAG CAGCATGAGA 
AGGCGGTGGA GCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LIN7B ( XM_017027131.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016882620.1 Homo sapiens lin-7 homolog B, crumbs cell polarity complex component (LIN7B), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu88658
Clone ID Related Accession (Same CDS sequence)	XM_017027131.2 , XM_017027131.1
Accession Version	XM_017027131.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 318bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	protein lin-7 homolog B isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTGCGC TGGTGGAGCC GCTGGGGCTG GAGCGGGACG TGTCCCGGGC GGTTGAGCTC 
CTCGAGCGGC TCCAGCGCAG CGGGGAGCTG CCGCCGCAGA AGCTGCAGGC CCTCCAGCGA 
GTTCTGCAGA GCCGCTTCTG CTCCGCTATC CGAGAGGGCT GGAGGAGCTG GCGACTCCCT 
GATGCCGCTG CCTCCTCACC CAGGTGTATG AGCAGCTTTA TGACACGCTG GACATCACCG 
GCAGCGCCGA GATCCGAGCC CATGCCACAG CCAAGAGCGT TGAGGGTGAG CAGCATGAGA 
AGGCGGTGGA GCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016882620.1
CDS	67..384
Translation	MAALVEPLGLERDVSRAVELLERLQRSGELPPQKLQALQRVLQSRFCSAIREGWRSWRLPDAAASSPRCMSSFMTRWTSPAAPRSEPMPQPRALRVSSMRRRWSC

Target ORF information:

RefSeq Version	XM_017027131.1
Organism	Homo sapiens(human)
Definition	Homo sapiens lin-7 homolog B, crumbs cell polarity complex component (LIN7B), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017027131.1

ORF Insert Sequence:

ATGGCTGCGC TGGTGGAGCC GCTGGGGCTG GAGCGGGACG TGTCCCGGGC GGTTGAGCTC 
CTCGAGCGGC TCCAGCGCAG CGGGGAGCTG CCGCCGCAGA AGCTGCAGGC CCTCCAGCGA 
GTTCTGCAGA GCCGCTTCTG CTCCGCTATC CGAGAGGGCT GGAGGAGCTG GCGACTCCCT 
GATGCCGCTG CCTCCTCACC CAGGTGTATG AGCAGCTTTA TGACACGCTG GACATCACCG 
GCAGCGCCGA GATCCGAGCC CATGCCACAG CCAAGAGCGT TGAGGGTGAG CAGCATGAGA 
AGGCGGTGGA GCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Role of an adaptor protein Lin-7B in brain development: possible involvement in autism spectrum disorders.
Journal of neurochemistry132(1)61-9(2015 Jan)
Mizuno M,Matsumoto A,Hamada N,Ito H,Miyauchi A,Jimbo EF,Momoi MY,Tabata H,Yamagata T,Nagata K

Decreased Lin7b expression in layer 5 pyramidal neurons may contribute to impaired corticostriatal connectivity in huntington disease.
Journal of neuropathology and experimental neurology69(9)880-95(2010 Sep)
Zucker B,Kama JA,Kuhn A,Thu D,Orlando LR,Dunah AW,Gokce O,Taylor DM,Lambeck J,Friedrich B,Lindenberg KS,Faull RL,Weiller C,Young AB,Luthi-Carter R

Association study of brain-derived neurotrophic factor (BDNF) and LIN-7 homolog (LIN-7) genes with adult attention-deficit/hyperactivity disorder.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics147B(6)945-51(2008 Sep)
Lanktree M,Squassina A,Krinsky M,Strauss J,Jain U,Macciardi F,Kennedy JL,Muglia P

The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions.
The Journal of biological chemistry282(13)9392-400(2007 Mar)
Bohl J,Brimer N,Lyons C,Vande Pol SB

Identification of a cell polarity-related protein, Lin-7B, as a binding partner for a Rho effector, Rhotekin, and their possible interaction in neurons.
Neuroscience research56(4)347-55(2006 Dec)
Sudo K,Ito H,Iwamoto I,Morishita R,Asano T,Nagata K

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LIN7B cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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