RRAGC cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RRAGC
Entrez Gene ID	64121
Full Name	Ras related GTP binding C
Synonyms	GTR2,RAGC,TIB929
General protein information	Preferred Names Ras related GTP binding C Names ras-related GTP-binding protein C GTPase-interacting protein 2 Rag C protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p34.3
Summary	This gene encodes a member of the GTR/RAG GTP-binding protein family. The encoded protein is a monomeric guanine nucleotide-binding protein which forms a heterodimer with RRAGA and RRAGB and is primarily localized to the cytoplasm. The encoded protein promotes intracellular localization of the mTOR complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012].
Disorder MIM:	608267

mRNA and Protein(s)

mRNA	Protein	Name
NM_022157.3	NP_071440.1	ras-related GTP-binding protein C isoform 1
NM_001271851.1	NP_001258780.1	ras-related GTP-binding protein C isoform 2
NM_022157.4	NP_071440.1	ras-related GTP-binding protein C isoform 1
NM_001271851.2	NP_001258780.1	ras-related GTP-binding protein C isoform 2

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	rragca	NP_001018471.1
Drosophila melanogaster (fruit fly)	RagC	NP_610361.1
Pan troglodytes (chimpanzee)	RRAGC	XP_513334.3
Rattus norvegicus (Norway rat)	Rragc	NP_001041649.1
Neurospora crassa	NCU00376	XP_957262.2
Homo sapiens (human)	RRAGC	NP_071440.1
Canis lupus familiaris (dog)	RRAGC	XP_003432000.1
Bos taurus (cattle)	RRAGC	NP_001069924.1
Schizosaccharomyces pombe (fission yeast)	gtr2	NP_588251.1
Xenopus tropicalis (tropical clawed frog)	rragc	NP_001016835.1
Mus musculus (house mouse)	Rragc	NP_059503.2
Gallus gallus (chicken)	RRAGC	NP_001026067.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007634	XP_308236.4
Magnaporthe oryzae (rice blast fungus)	MGG_05694	XP_003710593.1
	RRAGC	XP_001113124.1
Caenorhabditis elegans (roundworm)	ragc-1	NP_502187.1

Gene Ontology
Bibliography

Related articles in PubMed

Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex.
Su MY, Morris KL, Kim DJ, Fu Y, Lawrence R, Stjepanovic G, Zoncu R, Hurley JH
Molecular cell68(5)835-846.e3(2017 Dec)

Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability.
Shen K, Choe A, Sabatini DM
Molecular cell68(3)552-565.e8(2017 Nov)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Recurrent Mutations in the MTOR Regulator RRAGC in Follicular Lymphoma.
Ying ZX, Jin M, Peterson LF, Bernard D, Saiya-Cork K, Yildiz M, Wang S, Kaminski MS, Chang AE, Klionsky DJ, Malek SN
Clinical cancer research : an official journal of the American Association for Cancer Research22(21)5383-5393(2016 Nov)

De novo RRAGC mutation activates mTORC1 signaling in syndromic fetal dilated cardiomyopathy.
Long PA, Zimmermann MT, Kim M, Evans JM, Xu X, Olson TM
Human genetics135(8)909-917(2016 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Full-length RagA(GTP):RagC(GDP) dimer binds to regulator to activate mTORC1.
Title: Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex.

The dynamic response of mTORC1 requires intersubunit communication by the Rag GTPases, providing a rationale for why they exist as a dimer and revealing a distinct mode of control for a GTP-binding protein.
Title: Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability.

Multiple RRAGC mutations demonstrated elevated MTOR activation.
Title: Recurrent Mutations in the MTOR Regulator RRAGC in Follicular Lymphoma.

These findings implicate mTORC1 dysregulation through a gain-of-function mutation in RagC as a novel molecular basis for syndromic forms of pediatric heart failure, and expand genotype-phenotype correlation in RASopathy-related syndromes
Title: De novo RRAGC mutation activates mTORC1 signaling in syndromic fetal dilated cardiomyopathy.

activating nature of the RRAGC mutations, their existence in the dominant clone and their stability during disease progression support their potential as an excellent candidate for therapeutic targeting
Title: Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma.

The following RRAGC gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RRAGC cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu07750	NM_022157.4 Latest version!	Homo sapiens Ras related GTP binding C (RRAGC), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu08306	NM_001271851.2 Latest version!	Homo sapiens Ras related GTP binding C (RRAGC), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
View Old Accession Versions >>
OHu07750	NM_022157.3	Homo sapiens Ras related GTP binding C (RRAGC), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu08306	NM_001271851.1	Homo sapiens Ras related GTP binding C (RRAGC), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RRAGC ( NM_022157.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_071440.1 Homo sapiens Ras related GTP binding C (RRAGC), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu07750
Clone ID Related Accession (Same CDS sequence)	NM_022157.3 , NM_022157.4
Accession Version	NM_022157.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1200bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-31
Organism	Homo sapiens(human)
Product	ras-related GTP-binding protein C isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL139260.19, BG717489.1, BI461665.1, AK315791.1, BC016668.1, CA449149.1, CX761032.1, CB132041.1, HY264464.1, HY202961.1 and BQ003663.1. On Dec 5, 2012 this sequence version replaced NM_022157.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.61984.1, SRR1660807.257596.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2159080 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCCTGC AGTACGGGGC GGAGGAGACG CCCCTCGCCG GCAGTTACGG CGCGGCCGAT 
TCGTTTCCAA AGGACTTCGG CTACGGCGTG GAGGAGGAGG AAGAGGAGGC GGCGGCGGCG 
GGCGGAGGGG TTGGGGCAGG GGCAGGCGGT GGCTGTGGTC CGGGGGGCGC TGACAGCTCC 
AAGCCGAGGA TTCTGCTCAT GGGACTCCGG CGCAGCGGCA AGTCCTCCAT CCAGAAGGTG 
GTGTTTCATA AGATGTCACC CAACGAGACC CTCTTTTTGG AAAGTACCAA CAAGATTTAT 
AAGGATGACA TTTCCAATAG CTCCTTTGTG AATTTCCAGA TATGGGATTT TCCTGGGCAA 
ATGGACTTTT TTGACCCAAC CTTTGACTAT GAGATGATCT TCAGGGGAAC AGGAGCATTG 
ATATACGTCA TTGACGCACA GGATGACTAC ATGGAGGCTT TAACAAGACT TCACATTACT 
GTTTCTAAAG CCTACAAAGT TAACCCAGAC ATGAATTTTG AGGTTTTTAT TCACAAAGTT 
GATGGTCTGT CTGATGATCA CAAAATAGAA ACACAGAGGG ACATTCATCA AAGGGCCAAT 
GATGACCTTG CAGATGCTGG GCTAGAAAAA CTCCATCTTA GCTTTTATCT GACTAGTATC 
TATGACCATT CAATATTTGA AGCCTTTAGT AAGGTGGTGC AGAAACTCAT TCCACAACTG 
CCGACCTTGG AAAACCTATT AAATATCTTT ATATCAAATT CAGGTATTGA AAAAGCTTTT 
CTCTTTGATG TTGTCAGCAA AATCTACATT GCAACAGACA GTTCCCCTGT GGATATGCAA 
TCTTATGAAC TTTGCTGTGA CATGATCGAT GTTGTAATTG ATGTGTCTTG TATATATGGG 
TTAAAGGAAG ATGGAAGTGG AAGTGCTTAT GACAAAGAAT CTATGGCAAT TATCAAGCTG 
AATAATACAA CTGTCCTTTA TTTAAAGGAG GTGACTAAAT TTTTGGCACT GGTCTGCATT 
CTAAGGGAAG AAAGCTTTGA AAGAAAAGGT TTAATAGACT ACAACTTCCA CTGTTTCCGA 
AAAGCTATTC ATGAGGTTTT TGAGGTGGGT GTGACTTCTC ACAGGAGCTG TGGTCACCAG 
ACTAGTGCCT CCAGTCTGAA AGCGCTGACA CACAATGGCA CGCCACGAAA CGCCATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071440.1
CDS	178..1377
Translation	MSLQYGAEETPLAGSYGAADSFPKDFGYGVEEEEEEAAAAGGGVGAGAGGGCGPGGADSSKPRILLMGLRRSGKSSIQKVVFHKMSPNETLFLESTNKIYKDDISNSSFVNFQIWDFPGQMDFFDPTFDYEMIFRGTGALIYVIDAQDDYMEALTRLHITVSKAYKVNPDMNFEVFIHKVDGLSDDHKIETQRDIHQRANDDLADAGLEKLHLSFYLTSIYDHSIFEAFSKVVQKLIPQLPTLENLLNIFISNSGIEKAFLFDVVSKIYIATDSSPVDMQSYELCCDMIDVVIDVSCIYGLKEDGSGSAYDKESMAIIKLNNTTVLYLKEVTKFLALVCILREESFERKGLIDYNFHCFRKAIHEVFEVGVTSHRSCGHQTSASSLKALTHNGTPRNAI

Target ORF information:

RefSeq Version	NM_022157.3
Organism	Homo sapiens(human)
Definition	Homo sapiens Ras related GTP binding C (RRAGC), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022157.3

ORF Insert Sequence:

ATGTCCCTGC AGTACGGGGC GGAGGAGACG CCCCTCGCCG GCAGTTACGG CGCGGCCGAT 
TCGTTTCCAA AGGACTTCGG CTACGGCGTG GAGGAGGAGG AAGAGGAGGC GGCGGCGGCG 
GGCGGAGGGG TTGGGGCAGG GGCAGGCGGT GGCTGTGGTC CGGGGGGCGC TGACAGCTCC 
AAGCCGAGGA TTCTGCTCAT GGGACTCCGG CGCAGCGGCA AGTCCTCCAT CCAGAAGGTG 
GTGTTTCATA AGATGTCACC CAACGAGACC CTCTTTTTGG AAAGTACCAA CAAGATTTAT 
AAGGATGACA TTTCCAATAG CTCCTTTGTG AATTTCCAGA TATGGGATTT TCCTGGGCAA 
ATGGACTTTT TTGACCCAAC CTTTGACTAT GAGATGATCT TCAGGGGAAC AGGAGCATTG 
ATATACGTCA TTGACGCACA GGATGACTAC ATGGAGGCTT TAACAAGACT TCACATTACT 
GTTTCTAAAG CCTACAAAGT TAACCCAGAC ATGAATTTTG AGGTTTTTAT TCACAAAGTT 
GATGGTCTGT CTGATGATCA CAAAATAGAA ACACAGAGGG ACATTCATCA AAGGGCCAAT 
GATGACCTTG CAGATGCTGG GCTAGAAAAA CTCCATCTTA GCTTTTATCT GACTAGTATC 
TATGACCATT CAATATTTGA AGCCTTTAGT AAGGTGGTGC AGAAACTCAT TCCACAACTG 
CCGACCTTGG AAAACCTATT AAATATCTTT ATATCAAATT CAGGTATTGA AAAAGCTTTT 
CTCTTTGATG TTGTCAGCAA AATCTACATT GCAACAGACA GTTCCCCTGT GGATATGCAA 
TCTTATGAAC TTTGCTGTGA CATGATCGAT GTTGTAATTG ATGTGTCTTG TATATATGGG 
TTAAAGGAAG ATGGAAGTGG AAGTGCTTAT GACAAAGAAT CTATGGCAAT TATCAAGCTG 
AATAATACAA CTGTCCTTTA TTTAAAGGAG GTGACTAAAT TTTTGGCACT GGTCTGCATT 
CTAAGGGAAG AAAGCTTTGA AAGAAAAGGT TTAATAGACT ACAACTTCCA CTGTTTCCGA 
AAAGCTATTC ATGAGGTTTT TGAGGTGGGT GTGACTTCTC ACAGGAGCTG TGGTCACCAG 
ACTAGTGCCT CCAGTCTGAA AGCGCTGACA CACAATGGCA CGCCACGAAA CGCCATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RRAGC ( NM_022157.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_071440.1 Homo sapiens Ras related GTP binding C (RRAGC), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu07750
Clone ID Related Accession (Same CDS sequence)	NM_022157.3 , NM_022157.4
Accession Version	NM_022157.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1200bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Homo sapiens(human)
Product	ras-related GTP-binding protein C isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI461665.1, AK315791.1, BC016668.1, CA449149.1, CX761032.1, CB132041.1, HY264464.1, HY202961.1 and BQ003663.1. On Nov 22, 2018 this sequence version replaced NM_022157.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.1000533.1, SRR1803613.61984.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2159080 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000373001.4/ ENSP00000362092.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCCCTGC AGTACGGGGC GGAGGAGACG CCCCTCGCCG GCAGTTACGG CGCGGCCGAT 
TCGTTTCCAA AGGACTTCGG CTACGGCGTG GAGGAGGAGG AAGAGGAGGC GGCGGCGGCG 
GGCGGAGGGG TTGGGGCAGG GGCAGGCGGT GGCTGTGGTC CGGGGGGCGC TGACAGCTCC 
AAGCCGAGGA TTCTGCTCAT GGGACTCCGG CGCAGCGGCA AGTCCTCCAT CCAGAAGGTG 
GTGTTTCATA AGATGTCACC CAACGAGACC CTCTTTTTGG AAAGTACCAA CAAGATTTAT 
AAGGATGACA TTTCCAATAG CTCCTTTGTG AATTTCCAGA TATGGGATTT TCCTGGGCAA 
ATGGACTTTT TTGACCCAAC CTTTGACTAT GAGATGATCT TCAGGGGAAC AGGAGCATTG 
ATATACGTCA TTGACGCACA GGATGACTAC ATGGAGGCTT TAACAAGACT TCACATTACT 
GTTTCTAAAG CCTACAAAGT TAACCCAGAC ATGAATTTTG AGGTTTTTAT TCACAAAGTT 
GATGGTCTGT CTGATGATCA CAAAATAGAA ACACAGAGGG ACATTCATCA AAGGGCCAAT 
GATGACCTTG CAGATGCTGG GCTAGAAAAA CTCCATCTTA GCTTTTATCT GACTAGTATC 
TATGACCATT CAATATTTGA AGCCTTTAGT AAGGTGGTGC AGAAACTCAT TCCACAACTG 
CCGACCTTGG AAAACCTATT AAATATCTTT ATATCAAATT CAGGTATTGA AAAAGCTTTT 
CTCTTTGATG TTGTCAGCAA AATCTACATT GCAACAGACA GTTCCCCTGT GGATATGCAA 
TCTTATGAAC TTTGCTGTGA CATGATCGAT GTTGTAATTG ATGTGTCTTG TATATATGGG 
TTAAAGGAAG ATGGAAGTGG AAGTGCTTAT GACAAAGAAT CTATGGCAAT TATCAAGCTG 
AATAATACAA CTGTCCTTTA TTTAAAGGAG GTGACTAAAT TTTTGGCACT GGTCTGCATT 
CTAAGGGAAG AAAGCTTTGA AAGAAAAGGT TTAATAGACT ACAACTTCCA CTGTTTCCGA 
AAAGCTATTC ATGAGGTTTT TGAGGTGGGT GTGACTTCTC ACAGGAGCTG TGGTCACCAG 
ACTAGTGCCT CCAGTCTGAA AGCGCTGACA CACAATGGCA CGCCACGAAA CGCCATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071440.1
CDS	127..1326
Translation	MSLQYGAEETPLAGSYGAADSFPKDFGYGVEEEEEEAAAAGGGVGAGAGGGCGPGGADSSKPRILLMGLRRSGKSSIQKVVFHKMSPNETLFLESTNKIYKDDISNSSFVNFQIWDFPGQMDFFDPTFDYEMIFRGTGALIYVIDAQDDYMEALTRLHITVSKAYKVNPDMNFEVFIHKVDGLSDDHKIETQRDIHQRANDDLADAGLEKLHLSFYLTSIYDHSIFEAFSKVVQKLIPQLPTLENLLNIFISNSGIEKAFLFDVVSKIYIATDSSPVDMQSYELCCDMIDVVIDVSCIYGLKEDGSGSAYDKESMAIIKLNNTTVLYLKEVTKFLALVCILREESFERKGLIDYNFHCFRKAIHEVFEVGVTSHRSCGHQTSASSLKALTHNGTPRNAI

Target ORF information:

RefSeq Version	NM_022157.4
Organism	Homo sapiens(human)
Definition	Homo sapiens Ras related GTP binding C (RRAGC), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022157.4

ORF Insert Sequence:

ATGTCCCTGC AGTACGGGGC GGAGGAGACG CCCCTCGCCG GCAGTTACGG CGCGGCCGAT 
TCGTTTCCAA AGGACTTCGG CTACGGCGTG GAGGAGGAGG AAGAGGAGGC GGCGGCGGCG 
GGCGGAGGGG TTGGGGCAGG GGCAGGCGGT GGCTGTGGTC CGGGGGGCGC TGACAGCTCC 
AAGCCGAGGA TTCTGCTCAT GGGACTCCGG CGCAGCGGCA AGTCCTCCAT CCAGAAGGTG 
GTGTTTCATA AGATGTCACC CAACGAGACC CTCTTTTTGG AAAGTACCAA CAAGATTTAT 
AAGGATGACA TTTCCAATAG CTCCTTTGTG AATTTCCAGA TATGGGATTT TCCTGGGCAA 
ATGGACTTTT TTGACCCAAC CTTTGACTAT GAGATGATCT TCAGGGGAAC AGGAGCATTG 
ATATACGTCA TTGACGCACA GGATGACTAC ATGGAGGCTT TAACAAGACT TCACATTACT 
GTTTCTAAAG CCTACAAAGT TAACCCAGAC ATGAATTTTG AGGTTTTTAT TCACAAAGTT 
GATGGTCTGT CTGATGATCA CAAAATAGAA ACACAGAGGG ACATTCATCA AAGGGCCAAT 
GATGACCTTG CAGATGCTGG GCTAGAAAAA CTCCATCTTA GCTTTTATCT GACTAGTATC 
TATGACCATT CAATATTTGA AGCCTTTAGT AAGGTGGTGC AGAAACTCAT TCCACAACTG 
CCGACCTTGG AAAACCTATT AAATATCTTT ATATCAAATT CAGGTATTGA AAAAGCTTTT 
CTCTTTGATG TTGTCAGCAA AATCTACATT GCAACAGACA GTTCCCCTGT GGATATGCAA 
TCTTATGAAC TTTGCTGTGA CATGATCGAT GTTGTAATTG ATGTGTCTTG TATATATGGG 
TTAAAGGAAG ATGGAAGTGG AAGTGCTTAT GACAAAGAAT CTATGGCAAT TATCAAGCTG 
AATAATACAA CTGTCCTTTA TTTAAAGGAG GTGACTAAAT TTTTGGCACT GGTCTGCATT 
CTAAGGGAAG AAAGCTTTGA AAGAAAAGGT TTAATAGACT ACAACTTCCA CTGTTTCCGA 
AAAGCTATTC ATGAGGTTTT TGAGGTGGGT GTGACTTCTC ACAGGAGCTG TGGTCACCAG 
ACTAGTGCCT CCAGTCTGAA AGCGCTGACA CACAATGGCA CGCCACGAAA CGCCATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RRAGC ( NM_001271851.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001258780.1 Homo sapiens Ras related GTP binding C (RRAGC), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu08306
Clone ID Related Accession (Same CDS sequence)	NM_001271851.1 , NM_001271851.2
Accession Version	NM_001271851.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1098bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	ras-related GTP-binding protein C isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL139260.19, BG717489.1, BI461665.1, ES308561.1, AK298788.1, BC016668.1, AW327252.1, AK298573.1, CX761032.1, CB132041.1, HY264464.1, HY202961.1 and BQ003663.1. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. It encodes isoform 2 which is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK298788.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCCTGC AGTACGGGGC GGAGGAGACG CCCCTCGCCG GCAGTTACGG CGCGGCCGAT 
TCGTTTCCAA AGGACTTCGG CTACGGCGTG GAGGAGGAGG AAGAGGAGGC GGCGGCGGCG 
GGCGGAGGGG TTGGGGCAGG GGCAGGCGGT GGCTGTGGTC CGGGGGGCGC TGACAGCTCC 
AAGCCGAGGA TTCTGCTCAT GGGACTCCGG CGCAGCGGCA AGTCCTCCAT CCAGAAGATA 
TGGGATTTTC CTGGGCAAAT GGACTTTTTT GACCCAACCT TTGACTATGA GATGATCTTC 
AGGGGAACAG GAGCATTGAT ATACGTCATT GACGCACAGG ATGACTACAT GGAGGCTTTA 
ACAAGACTTC ACATTACTGT TTCTAAAGCC TACAAAGTTA ACCCAGACAT GAATTTTGAG 
GTTTTTATTC ACAAAGTTGA TGGTCTGTCT GATGATCACA AAATAGAAAC ACAGAGGGAC 
ATTCATCAAA GGGCCAATGA TGACCTTGCA GATGCTGGGC TAGAAAAACT CCATCTTAGC 
TTTTATCTGA CTAGTATCTA TGACCATTCA ATATTTGAAG CCTTTAGTAA GGTGGTGCAG 
AAACTCATTC CACAACTGCC GACCTTGGAA AACCTATTAA ATATCTTTAT ATCAAATTCA 
GGTATTGAAA AAGCTTTTCT CTTTGATGTT GTCAGCAAAA TCTACATTGC AACAGACAGT 
TCCCCTGTGG ATATGCAATC TTATGAACTT TGCTGTGACA TGATCGATGT TGTAATTGAT 
GTGTCTTGTA TATATGGGTT AAAGGAAGAT GGAAGTGGAA GTGCTTATGA CAAAGAATCT 
ATGGCAATTA TCAAGCTGAA TAATACAACT GTCCTTTATT TAAAGGAGGT GACTAAATTT 
TTGGCACTGG TCTGCATTCT AAGGGAAGAA AGCTTTGAAA GAAAAGGTTT AATAGACTAC 
AACTTCCACT GTTTCCGAAA AGCTATTCAT GAGGTTTTTG AGGTGGGTGT GACTTCTCAC 
AGGAGCTGTG GTCACCAGAC TAGTGCCTCC AGTCTGAAAG CGCTGACACA CAATGGCACG 
CCACGAAACG CCATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001258780.1
CDS	178..1275
Translation	MSLQYGAEETPLAGSYGAADSFPKDFGYGVEEEEEEAAAAGGGVGAGAGGGCGPGGADSSKPRILLMGLRRSGKSSIQKIWDFPGQMDFFDPTFDYEMIFRGTGALIYVIDAQDDYMEALTRLHITVSKAYKVNPDMNFEVFIHKVDGLSDDHKIETQRDIHQRANDDLADAGLEKLHLSFYLTSIYDHSIFEAFSKVVQKLIPQLPTLENLLNIFISNSGIEKAFLFDVVSKIYIATDSSPVDMQSYELCCDMIDVVIDVSCIYGLKEDGSGSAYDKESMAIIKLNNTTVLYLKEVTKFLALVCILREESFERKGLIDYNFHCFRKAIHEVFEVGVTSHRSCGHQTSASSLKALTHNGTPRNAI

Target ORF information:

RefSeq Version	NM_001271851.1
Organism	Homo sapiens(human)
Definition	Homo sapiens Ras related GTP binding C (RRAGC), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001271851.1

ORF Insert Sequence:

ATGTCCCTGC AGTACGGGGC GGAGGAGACG CCCCTCGCCG GCAGTTACGG CGCGGCCGAT 
TCGTTTCCAA AGGACTTCGG CTACGGCGTG GAGGAGGAGG AAGAGGAGGC GGCGGCGGCG 
GGCGGAGGGG TTGGGGCAGG GGCAGGCGGT GGCTGTGGTC CGGGGGGCGC TGACAGCTCC 
AAGCCGAGGA TTCTGCTCAT GGGACTCCGG CGCAGCGGCA AGTCCTCCAT CCAGAAGATA 
TGGGATTTTC CTGGGCAAAT GGACTTTTTT GACCCAACCT TTGACTATGA GATGATCTTC 
AGGGGAACAG GAGCATTGAT ATACGTCATT GACGCACAGG ATGACTACAT GGAGGCTTTA 
ACAAGACTTC ACATTACTGT TTCTAAAGCC TACAAAGTTA ACCCAGACAT GAATTTTGAG 
GTTTTTATTC ACAAAGTTGA TGGTCTGTCT GATGATCACA AAATAGAAAC ACAGAGGGAC 
ATTCATCAAA GGGCCAATGA TGACCTTGCA GATGCTGGGC TAGAAAAACT CCATCTTAGC 
TTTTATCTGA CTAGTATCTA TGACCATTCA ATATTTGAAG CCTTTAGTAA GGTGGTGCAG 
AAACTCATTC CACAACTGCC GACCTTGGAA AACCTATTAA ATATCTTTAT ATCAAATTCA 
GGTATTGAAA AAGCTTTTCT CTTTGATGTT GTCAGCAAAA TCTACATTGC AACAGACAGT 
TCCCCTGTGG ATATGCAATC TTATGAACTT TGCTGTGACA TGATCGATGT TGTAATTGAT 
GTGTCTTGTA TATATGGGTT AAAGGAAGAT GGAAGTGGAA GTGCTTATGA CAAAGAATCT 
ATGGCAATTA TCAAGCTGAA TAATACAACT GTCCTTTATT TAAAGGAGGT GACTAAATTT 
TTGGCACTGG TCTGCATTCT AAGGGAAGAA AGCTTTGAAA GAAAAGGTTT AATAGACTAC 
AACTTCCACT GTTTCCGAAA AGCTATTCAT GAGGTTTTTG AGGTGGGTGT GACTTCTCAC 
AGGAGCTGTG GTCACCAGAC TAGTGCCTCC AGTCTGAAAG CGCTGACACA CAATGGCACG 
CCACGAAACG CCATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RRAGC ( NM_001271851.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001258780.1 Homo sapiens Ras related GTP binding C (RRAGC), transcript variant 2, mRNA.

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CloneID	OHu08306
Clone ID Related Accession (Same CDS sequence)	NM_001271851.1 , NM_001271851.2
Accession Version	NM_001271851.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1098bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	ras-related GTP-binding protein C isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI461665.1, ES308561.1, AK298788.1, BC016668.1, AW327252.1, AK298573.1, CX761032.1, CB132041.1, HY264464.1, HY202961.1 and BQ003663.1. On May 31, 2019 this sequence version replaced NM_001271851.1. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. It encodes isoform 2 which is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK298788.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCCTGC AGTACGGGGC GGAGGAGACG CCCCTCGCCG GCAGTTACGG CGCGGCCGAT 
TCGTTTCCAA AGGACTTCGG CTACGGCGTG GAGGAGGAGG AAGAGGAGGC GGCGGCGGCG 
GGCGGAGGGG TTGGGGCAGG GGCAGGCGGT GGCTGTGGTC CGGGGGGCGC TGACAGCTCC 
AAGCCGAGGA TTCTGCTCAT GGGACTCCGG CGCAGCGGCA AGTCCTCCAT CCAGAAGATA 
TGGGATTTTC CTGGGCAAAT GGACTTTTTT GACCCAACCT TTGACTATGA GATGATCTTC 
AGGGGAACAG GAGCATTGAT ATACGTCATT GACGCACAGG ATGACTACAT GGAGGCTTTA 
ACAAGACTTC ACATTACTGT TTCTAAAGCC TACAAAGTTA ACCCAGACAT GAATTTTGAG 
GTTTTTATTC ACAAAGTTGA TGGTCTGTCT GATGATCACA AAATAGAAAC ACAGAGGGAC 
ATTCATCAAA GGGCCAATGA TGACCTTGCA GATGCTGGGC TAGAAAAACT CCATCTTAGC 
TTTTATCTGA CTAGTATCTA TGACCATTCA ATATTTGAAG CCTTTAGTAA GGTGGTGCAG 
AAACTCATTC CACAACTGCC GACCTTGGAA AACCTATTAA ATATCTTTAT ATCAAATTCA 
GGTATTGAAA AAGCTTTTCT CTTTGATGTT GTCAGCAAAA TCTACATTGC AACAGACAGT 
TCCCCTGTGG ATATGCAATC TTATGAACTT TGCTGTGACA TGATCGATGT TGTAATTGAT 
GTGTCTTGTA TATATGGGTT AAAGGAAGAT GGAAGTGGAA GTGCTTATGA CAAAGAATCT 
ATGGCAATTA TCAAGCTGAA TAATACAACT GTCCTTTATT TAAAGGAGGT GACTAAATTT 
TTGGCACTGG TCTGCATTCT AAGGGAAGAA AGCTTTGAAA GAAAAGGTTT AATAGACTAC 
AACTTCCACT GTTTCCGAAA AGCTATTCAT GAGGTTTTTG AGGTGGGTGT GACTTCTCAC 
AGGAGCTGTG GTCACCAGAC TAGTGCCTCC AGTCTGAAAG CGCTGACACA CAATGGCACG 
CCACGAAACG CCATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001258780.1
CDS	127..1224
Translation	MSLQYGAEETPLAGSYGAADSFPKDFGYGVEEEEEEAAAAGGGVGAGAGGGCGPGGADSSKPRILLMGLRRSGKSSIQKIWDFPGQMDFFDPTFDYEMIFRGTGALIYVIDAQDDYMEALTRLHITVSKAYKVNPDMNFEVFIHKVDGLSDDHKIETQRDIHQRANDDLADAGLEKLHLSFYLTSIYDHSIFEAFSKVVQKLIPQLPTLENLLNIFISNSGIEKAFLFDVVSKIYIATDSSPVDMQSYELCCDMIDVVIDVSCIYGLKEDGSGSAYDKESMAIIKLNNTTVLYLKEVTKFLALVCILREESFERKGLIDYNFHCFRKAIHEVFEVGVTSHRSCGHQTSASSLKALTHNGTPRNAI

Target ORF information:

RefSeq Version	NM_001271851.2
Organism	Homo sapiens(human)
Definition	Homo sapiens Ras related GTP binding C (RRAGC), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001271851.2

ORF Insert Sequence:

ATGTCCCTGC AGTACGGGGC GGAGGAGACG CCCCTCGCCG GCAGTTACGG CGCGGCCGAT 
TCGTTTCCAA AGGACTTCGG CTACGGCGTG GAGGAGGAGG AAGAGGAGGC GGCGGCGGCG 
GGCGGAGGGG TTGGGGCAGG GGCAGGCGGT GGCTGTGGTC CGGGGGGCGC TGACAGCTCC 
AAGCCGAGGA TTCTGCTCAT GGGACTCCGG CGCAGCGGCA AGTCCTCCAT CCAGAAGATA 
TGGGATTTTC CTGGGCAAAT GGACTTTTTT GACCCAACCT TTGACTATGA GATGATCTTC 
AGGGGAACAG GAGCATTGAT ATACGTCATT GACGCACAGG ATGACTACAT GGAGGCTTTA 
ACAAGACTTC ACATTACTGT TTCTAAAGCC TACAAAGTTA ACCCAGACAT GAATTTTGAG 
GTTTTTATTC ACAAAGTTGA TGGTCTGTCT GATGATCACA AAATAGAAAC ACAGAGGGAC 
ATTCATCAAA GGGCCAATGA TGACCTTGCA GATGCTGGGC TAGAAAAACT CCATCTTAGC 
TTTTATCTGA CTAGTATCTA TGACCATTCA ATATTTGAAG CCTTTAGTAA GGTGGTGCAG 
AAACTCATTC CACAACTGCC GACCTTGGAA AACCTATTAA ATATCTTTAT ATCAAATTCA 
GGTATTGAAA AAGCTTTTCT CTTTGATGTT GTCAGCAAAA TCTACATTGC AACAGACAGT 
TCCCCTGTGG ATATGCAATC TTATGAACTT TGCTGTGACA TGATCGATGT TGTAATTGAT 
GTGTCTTGTA TATATGGGTT AAAGGAAGAT GGAAGTGGAA GTGCTTATGA CAAAGAATCT 
ATGGCAATTA TCAAGCTGAA TAATACAACT GTCCTTTATT TAAAGGAGGT GACTAAATTT 
TTGGCACTGG TCTGCATTCT AAGGGAAGAA AGCTTTGAAA GAAAAGGTTT AATAGACTAC 
AACTTCCACT GTTTCCGAAA AGCTATTCAT GAGGTTTTTG AGGTGGGTGT GACTTCTCAC 
AGGAGCTGTG GTCACCAGAC TAGTGCCTCC AGTCTGAAAG CGCTGACACA CAATGGCACG 
CCACGAAACG CCATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex.
Molecular cell68(5)835-846.e3(2017 Dec)
Su MY,Morris KL,Kim DJ,Fu Y,Lawrence R,Stjepanovic G,Zoncu R,Hurley JH

Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability.
Molecular cell68(3)552-565.e8(2017 Nov)
Shen K,Choe A,Sabatini DM

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Recurrent Mutations in the MTOR Regulator RRAGC in Follicular Lymphoma.
Clinical cancer research : an official journal of the American Association for Cancer Research22(21)5383-5393(2016 Nov)
Ying ZX,Jin M,Peterson LF,Bernard D,Saiya-Cork K,Yildiz M,Wang S,Kaminski MS,Chang AE,Klionsky DJ,Malek SN

De novo RRAGC mutation activates mTORC1 signaling in syndromic fetal dilated cardiomyopathy.
Human genetics135(8)909-917(2016 Aug)
Long PA,Zimmermann MT,Kim M,Evans JM,Xu X,Olson TM

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RRAGC cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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